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  • Nature Publishing Company  (430)
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  • 1992  (430)
  • 1
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Potato plants transgenic for the coat protein (CP) gene of potato virus Y strain N (PVYN) were examined for the accumulation of the transgenic PVYN CP. The protein remained undetectable in healthy plants of lines Bt6 and Bt10 that are completely or partially resistant to this virus, but accumulated ...
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  • 2
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    Nature biotechnology 10 (1992), S. 1045-1046 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Flask. A new culture flask from Corning Science Products (Corning, NY) has a vented cap that helps protect cells while maximizing cell growth. It is ideal for all cell cultures that are sensitive to contaminants. There is a .22-m membrane in the cap that ensures against constant gas exchange and ...
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  • 3
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    Nature biotechnology 10 (1992), S. 936-937 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Stephen Edgington's article, “Biotech Vaccines' Problematic Promise” [Bio/Technology 10:766 (1992)] was generally informative, but his discussion of FDA's regulation of vaccines was inaccurate and confusing. Edgington is muddled on what applications must be submitted to ...
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  • 4
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    Nature biotechnology 10 (1992), S. 940-945 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] •The U.S. Food and Drug Administration (FDA, Bethesda, MD) and the drug industry are near an agreement regarding user fees to speed up the drug approval process. Under the plan, FDA proposes that drug companies pay several fees: $150,000 for each drug application, regardless of whether ...
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  • 5
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    Nature biotechnology 10 (1992), S. 952-953 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] TOKYO?Milk has been described as the perfect food, but of course, it's not. Neither are beef, tofu, corn, or wheat. In fact, no food is—unless it could be modified to supply the amino acids, minerals, vitamins, and fibers that it lacks in its natural state. Enter biotechnology. Genetic ...
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  • 6
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    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 962-962 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Despite a general hiring freeze at the Food and Drug Administration (FDA, Bethesda, MD), Commissioner David Kessler says the agency will soon meet its promise of hiring 50 new staff members to review new biotech drugs. During a recent press briefing, Kessler also said that ...
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  • 7
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    Nature biotechnology 10 (1992), S. 963-966 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bio/Technology conducted its first reader compensation survey in 1988. Back then, the average reported compensation was in the $50,000-$60,000 range. This year, the average compensation is about $30,000 a year higher than that. The scope of the enterprise Bio/Technology's ...
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  • 8
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    Nature biotechnology 10 (1992), S. 973-980 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pharmaceutics is an honorable pursuit, but surely so ambitious it verges on the foolhardy. It attempts to tip the fine balance between human health and disease, both states complex and poorly understood, by administering low-molecular mass drugs—by molecular tweaking. First, consider that ...
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  • 9
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    Nature biotechnology 10 (1992), S. 993-996 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Oligonuclotide-based therapeutics hypothetically stand poised to reshape the pharmaceutical industry (see, for example, Bio/Technology 10:256–262, March 1992). At least 24 companies worldwide have dedicated a major portion of their resources to fighting everything from viruses to oncogenes ...
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  • 10
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    Nature biotechnology 10 (1992), S. 830-830 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Russ Hoyle's commentary, “Eating Biotechnology” (Bio/Technology 10:629, June), discusses the Food and Drug Administration's (FDA) policy for foods derived from new plant varieties, but mischaracterizes our policy in several important aspects—possibly because at the ...
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  • 11
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    Nature biotechnology 10 (1992), S. 833-833 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The negotiators have completed their task, and at long last we have a chemical weapons convention. All that remains to be done, after decades of logic chopping in Geneva, is for 65 nations to ratify the text. But that, of course, may take several more years. Only then, perhaps, will those nations, ...
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  • 12
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    Nature biotechnology 10 (1992), S. 846-847 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Early-stage biopharmaceutical stocks, essentially those companies that came public during 1991 and early 1992, have considerably underperformed more mature biotechnology stocks during the 1992 correction. At this point, the unattractive elements of these stocks to investors are severalfold. They ...
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  • 13
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    Nature biotechnology 10 (1992), S. 981-985 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the turn of the century, Alexis Carrel, the father of modern day tissue culture (see Bio/ Technology 10:855–860, August 1992) found that if he grew a tumor on a fibrous clot it lysed the clot, but normal cells grown on the same clot had no effect. Carrel suspected soluble factors from the ...
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  • 14
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    Nature biotechnology 10 (1992), S. 994-995 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As activity gears up for oligonucleotide therapies, companies devote additional resources to its promise. Nearly all companies make boiler-plate claims for their products: readily enter tissues and cells, are resistant to enzymatic degradation, have ideal targeting characteristics, and are ...
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  • 15
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    Nature biotechnology 10 (1992), S. 870-872 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Today's biotherapeutics must meets tringentpurity requirements—extraneous nucleic acids, viruses, endotoxins, host cell proteins, and additives from fermentation or cell culture media must all be removed from the product. It is also necessary to remove product aggregates, which are ...
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  • 16
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    Nature biotechnology 10 (1992), S. 830-831 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: PROSAMO (Planned Release of Selected and Modified Organisms) is a three-year plant and microbial research programme operating as a partnership between the U.K. government (DTI), AFRC, industry (a consortium often major biotechnology companies), and four leading academic research ...
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  • 17
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    Nature biotechnology 10 (1992), S. 831-831 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Figure 3 was inadvertently omitted from “Interactions in the Fourth Dimension” by Puss Granww and Robert Reed (Bio/Technology 10:399–393). The missing figure is reproduced below. FIGURE 3. The effect of amino acid changes in the Z domain of Protein A on the on-rate and off-rate ...
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  • 18
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    Nature biotechnology 10 (1992), S. 840-840 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Two gene-therapy proposals for combating HIV infections recently ran into virtually opposite receptions from different federal review committees. These cases— one involving the National Institutes of Health (NIH, Bethesda, MD) and the other the Food and Drug ...
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  • 19
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    Nature biotechnology 10 (1992), S. 843-843 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—As this year's second quarter ended, the record-shattering 1991/ 1992 public-financing window for U.S. biotechnology companies seemed to slam shut. So far, 132 biotech companies have raised $5.2 billion through stock offerings, including $2 billion through 64 initial ...
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  • 20
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    Nature biotechnology 10 (1992), S. 848-849 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Just before the United Nations Conference on the Environment and Development (UNCED) convened in Rio this past June, the Bush administration abruptly decided not to sign the so-called biodiversity treaty, an international convention to preserve the world's biological species. The move, widely but ...
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  • 21
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    Nature biotechnology 10 (1992), S. 864-865 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Technical advances have raised transgenic animal technology to the status of a cost-effective alternative for producing certain proteins. So does that mean that the challenge really facing this emerging industry is regulatory clearance? The U.S. Food and Drug Administration (FDA, Bethesda, MD) and ...
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  • 22
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    Nature biotechnology 10 (1992), S. 873-875 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human resource management— the art of employing, developing and managing people—is needed more, and needed earlier, in biotechnology than in perhaps any other sector. As human resources professionals in biotechnology we would say that, wouldn't we—but that does not mean it is not ...
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  • 23
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have engineered an industrial strain of the yeast, Candida tropicalis, for the efficient production of long–chain dicarboxylic acids, which are important raw materials for the chemical industry. By sequential disruption of the four genes encoding both isozymes of the acyl–CoA oxidase ...
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  • 24
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    Nature biotechnology 10 (1992), S. 916-917 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Disposable. From Microgon (Laguna Hills, CA) comes disposable membrane modules for fast, convenient, microporous separations. The membranes concentrate animal and microbial cells, separate cells from proteins, and wash cells or diagnostic particles to recover or remove large proteins. Membrane ...
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  • 25
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    Nature biotechnology 10 (1992), S. 921-921 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Line. Shimadzu Scientific Instruments (Columbia, MD) presents its 32-page catalog outlining an extensive line of chromatography, spectroscopy, environmental, and physical testing instrumentation offered in North America. The catalog features the recently introduced LC-10A Series HPLC system. Write ...
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  • 26
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    Nature biotechnology 10 (1992), S. 717-717 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An old friend writes to suggest a “paean to FDA's food biotech policy”: The U.S. Food and Drug Administration's May 29 Statement of Policy: Food Derived from New Plant Varieties is “scientifically sound ⃜ riskbased⃜ workable…[and] safeguards the public ...
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  • 27
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    Nature biotechnology 10 (1992), S. 728-730 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—U.S. companies have slashed research and development (R&D) spending. Largely because of a weak economy and industrial consolidation, annual real growth in industrial R&D outlays slowed to 1.5 percent between 1985 and 1990. In 1991 company research spending probably didn't ...
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  • 28
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    Nature biotechnology 10 (1992), S. 736-736 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Scios's (Mountain View, CA) proposed purchase of Nova Pharmaceuticals (Baltimore, MD) for $180 million in stock opened to mixed reviews, generating as much criticism as praise. Criticism was strong. “The combined company still lacks the critical mass to fully develop ...
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  • 29
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    Nature biotechnology 10 (1992), S. 740-741 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The U.S. Food and Drug Administration (FDA, Bethesda, MD) announced its policy for foods derived from genetically modified plant varieties, reaffirming that such foods will be judged on their characteristics, not on how die plant genes may have been manipulated. The ...
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  • 30
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    Nature biotechnology 10 (1992), S. 748-748 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SANTA CRUZ, Calif.—No more cardboard tomatoes. Consumers may be able to buy tomatoes from their grocer that are as good as what they could grow in their back yards: plump, juicy, red, and tasty. But these aren't Big Boys. They're probably Flavr Savrs or some other genetically manipulated ...
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  • 31
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    Nature biotechnology 10 (1992), S. 754-754 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the moment, DNA sequence data are used mainly by DNA sequencers and a few theoretical biologists. DNA sequencers need to search all previously published data fast and exhaustively. DNA sequences are also translated into protein sequences, which can yield clues to the protein's function ...
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  • 32
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    Nature biotechnology 10 (1992), S. 757-758 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The methods for DNA sequence determination that have held sway for the last decade are starting to be challenged by a new approach that may be far better suited to large-scale sequencing projects. Variously dubbed sequencing by hybridization, hybridization sequencing, and fragmentation sequencing ...
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  • 33
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    Nature biotechnology 10 (1992), S. 761-761 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The poster in this issue of Bio/rerhnology–WAST CHROMOSOME III-marks a milestone in large-scale genome sequencing and mapping. Yeast chromosome III is the longest piece of DNA yet sequenced (315, 357 base pairs). It is also the first entire chromosome sequence from any organism. Obtaining the ...
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  • 34
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    Nature biotechnology 10 (1992), S. 768-771 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In 1984 then U.S. Secretary of Health and Human Services Margaret Heckler announced that the cause of AIDS had been discovered, and that a vaccine was just around the corner. Having crossed the threshold of the 90s, Heckler's prophecy of an AIDS vaccine appears extremely optimistic. For most of ...
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  • 35
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One goal of protein design and structural biochemistry is the reduction of complex molecules to small functional units that are amenable to high resolution analysis and rapid modification. We have developed a variety of small molecules which biochemically and biologically mimic the combining sites ...
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  • 36
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Sequence–specific enzymatic cleavage of protein fusions is an important application in recombinant protein technology. We have used the Neisseria type 2 lgA protease (EC 3.4.24.13), produced and secreted by Escherichia coli host cells, for efficiently processing polypeptides at authentic or ...
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  • 37
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    Nature biotechnology 10 (1992), S. 809-810 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Purification. Barrskogen (Bowie, MD) introduces the DNA Mate, a cartridge purification system that automatically delivers solvents and reagents into DNA purification cartridges for the purification of trityl-on DNA (DMT-DNA). It is designed for use with available reversed phase cartridges for the ...
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  • 38
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    Nature biotechnology 10 (1992), S. 706-706 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: By advocating changes in the highly successful Orphan Drug Act (“Poor Little Rich Drugs?” Bio/Technology 10:464, April, 1992) , Senator Howard M. Metzenbaum would im pose unacceptable risks on the 10,000 to 20,000 Americans who suffer from the 5,000 rare diseases for ...
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  • 39
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    Nature biotechnology 10 (1992), S. 471-471 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] You've raised the working capital, found your field site in what estate agents call a desirable location, and built a stunning suite of labs and offices. You've recruited an eager team of young Ph.D.s and told the world about the new company through a handsome prospectus in a nice shade of green. ...
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  • 40
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    Nature biotechnology 10 (1992), S. 472-476 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Immunex (Seattle, WA) is filing suit against Hoechst (Frankfurt, Germany) and its subsidiaries Behringwerke and Hoechst Roussel Pharmaceuticals for breach of contract, business interference, and unfair competition in the marketing of GM-CSF, granulocyte macrophage-colony stimulating factor. The ...
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  • 41
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    Nature biotechnology 10 (1992), S. 712-712 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Thinking about having a biotech company of yrdquoour very own? If so, think long and hard about the fact that, no matter how brilliant your “baby” of a company is, its chances of surviving and growing without an extended “family” of experts and lots of ...
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  • 42
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    Nature biotechnology 10 (1992), S. 478-480 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEWYORK–Should sequencing of the human genome be turned over to a private company? Wealthy entrepreneur Frederick Bourke has stirred debate over that question by talking with a number of leading researchers about investing $50 million to build a company to do just that. [Company ...
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  • 43
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    Nature biotechnology 10 (1992), S. 481-481 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Public financing of U.S. biotechnology companies soared to record heights last year. Fully 85 companies raised a staggering $3.7 billion in stock offerings, including 39 initial public offerings (IPOs) that netted $1.2 billion. Such offerings continued their ...
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  • 44
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    Nature biotechnology 10 (1992), S. 487-487 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—When an upstart research company tells pharmaceutical firms it has the technology to propel their carbohydrate-based compounds from research curiosities to clinical-stage therapeutics and diagnostics, the pharmaceutical companies will be skeptical, but they might just listen. That ...
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  • 45
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    Nature biotechnology 10 (1992), S. 498-499 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Pharming—producing human pharmaceuticals in transgenic farm animals—is fast coming of age. Just five years ago, researchers proved pharming was possible when they engineered mice to make clot-dissolving tissue plasminogen activator in their milk. Now four biotechnology ...
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  • 46
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    Nature biotechnology 10 (1992), S. 654-658 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There are a number of myths about biotechnology that Bio/Technology, as its ears and voice, ought to correct. One of them, put about by some CEOs trying to grow small companies, is that there are only two countries in the world that are really active in biotechnology: the United States and the ...
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Having begun in earnest in the late 1970s, biotechnology produced about one out of every ten new drugs clinically tested in the U.S. during the 1980s. By 1989, this rate rose to about one out of three.1,2 Increasing investigational activity in this area has been paralleled by the growing ...
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    Nature biotechnology 10 (1992), S. 529-531 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US. business has traditionally considered international R & D secondary to domestic efforts, a necessity only for firms with mature markets at home or a luxury to be undertaken by the more profitable, larger firms. In the case of commercial biotechnology, however, firms that have not engaged in ...
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Monellin is a protein that elicits a flavor approximately 100,000 times sweeter than sugar on a molar basis. The protein exists naturally as a heterodimer, with its sweet flavor lost upon denaturation. A single–chain monellin gene, encoding both polypeptide chains linked by a hinge sequence, ...
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    Nature biotechnology 10 (1992), S. 600-600 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The U.S. biotechnology industry, I am convinced, is taking the wrong path in objecting to applications by the National Institutes of Health (NIH, Bethesda, MD) to patent its discoveries of thousands of human genes, in most cases without any knowledge of the specific functions of those genes. The ...
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    Nature biotechnology 10 (1992), S. 706-706 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: There is very little disagreement that the Orphan Drug Act has been a tremendous success. More drugs and treatments have been developed for orphan diseases in the last five years than ever before. It should be no surprise that the United States leads the world in the creation of ...
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    Nature biotechnology 10 (1992), S. 469-469 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] James Watson resigned in mid-April from the U.S. National Institutes of Health's genome project, apparently in an angry rebuttal to the NIH director's insistence that Watson's stock holdings in biotechnology and pharmaceutical companies appeared to present a conflict of interest. That got us ...
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    Nature biotechnology 10 (1992), S. 480-480 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—The news for thrombolytic agents was good, but the news for genetically engineered thrombolytics was bad. The results of the Third International Study of Infarct Survival (ISIS-3) showed duteplase—Burroughs Wellcome's (Research Triangle Park, NC) recombinant tissue plasminogen ...
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    Nature biotechnology 10 (1992), S. 484-484 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—The early 1980s were heady times for U.S. venture-capital funds. The funds—which typically raise $50 million and last 10 years—profit by investing in new companies and then selling them or taking them public. During the eighties, older funds—those five years ...
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    Nature biotechnology 10 (1992), S. 370-370 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] WASHINGTON, D.C.—Asin past years, the National Institutes of Health (NIH) received the biggest chunk of biotech research dollars in President George Bush's budget request for fiscal-year 1993. NIH got $2.9 billion, or 73 percent of the $4 billion proposed for biotech research. ...
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    Nature biotechnology 10 (1992), S. 376-376 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] CAMBRIDGE, Mass.—Three years ago Genentech's (So. San Francisco, CA) Con Gorman had a novel solution to an identity crisis. In the 20 plus years since the proinsulin pre cursor was found to convert to active insulin by “dibasic site” cleavage, scientists could not find the enzyme ...
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    Nature biotechnology 10 (1992), S. 383-389 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Your mother always told you sugar wasn't good for you. But a new class ofdrugs based on carbohydrate chemistry suggests she may be wrong–if you can believe the claims for selectin-mediating drugs. The first time around, many ofthese assertions make snake-oil salesmen sound credible: A new ...
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    Nature biotechnology 10 (1992), S. 374-374 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] NEW YORK—“Why transcription factors?” The question echoed through academia's ivy-covered halls and ricocheted off the glass-and-steel bastions of corporate biotechnology. The speculation centered as much on the validity offocusing a biotech company on transcription ...
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    Nature biotechnology 10 (1992), S. 378-380 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SANFRANCISCO—Where are thejobs? What skills do you need? For Northern California's growing biotechnology sector, there is an increasing need for “scientifically competent blue-collar workers,” according to Fred Dorey, executive director ofthe BayArea Bioscience Center (Oakland).As ...
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    Nature biotechnology 10 (1992), S. 394-396 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Many of the regulatory issues surrounding biotechnology stem from the difficulty (indeed, impossibility) of having full process control over biological production methods. And yet products such as monoclonal antibodies from hybridomas are now in clinical use and must made be safe. In particular, ...
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plant ribosome–inactivating proteins (RIPs) N–glycosidases which cleave the N–glycosidic bond of adenine in a specfic ribosomal RNA sequence. Most commonly RIPs are single–chain proteins (type 1 RIPs), but some (type 2 RIPs) possess a galactose–specific lectin domain ...
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    Nature biotechnology 10 (1992), S. 453-453 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] APRIL MEETINGS Apr. 5-7. Feeding the World, Protecting the Earth. Annapolis, MD. Info: Barbara Rose, Rockefeller Foundation Media Seminar, Int'l. Food Policy Research Inst., 1776 Massachusetts Ave., N.W., Washington, DC 20036. Tel: 202-862-8133. Apr. 5-10. American Chemical Society 203rd National ...
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    Nature biotechnology 10 (1992), S. 455-455 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Jay Hair (Bio/Technology 10:216, Feb. 1992), responding to Susanne Huttner (Bio/Technology9: 1400, Dec. '91), has listed a number of groups, in addition to Rifkin's organization, that are “currently working to evaluate and influence the development of this new ...
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    Nature biotechnology 10 (1992), S. 456-456 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The question of utility has already been raised as an issue in the patent applications NlH [National Institute of Health, Bethesda, MD] is filing for gene fragments (Bio/Technology 9:1310, Dec.'91), but there is another technical question that I haven't seen raised anywhere. If it ...
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    Nature biotechnology 10 (1992), S. 223-223 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] I lived in the rain of black soot that fell on Pittsburgh throughout World War II. I lived for several years in a house where the drinking water tasted of kerosene from the oil well above the spring. I have worked with asbestos, PCBs (gallons, not parts per million), benzene, and assorted other ...
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    Nature biotechnology 10 (1992), S. 234-234 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Immunex (Seattle, WA) pulled off a novel swap of cancer products with Bristol-Myers Squibb (BMS, New York) last month. Immunex gets U.S. marketing rights to 10 BMS cancer drugs with 1991 sales of $35 million. In return, BMS gets marketing rights outside North America to ...
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    Nature biotechnology 10 (1992), S. 578-578 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Antibodies. An antibodies catalog containing over 9,000 listings is available from Accurate Chemical & Scientific (Westbury, NY). It includes a line of cell separation media, and is available in printed form or on MAC and IBM 3-1/2 or 5-1/4 inch diskettes. Write in 705 on Reader Service Card ...
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    Nature biotechnology 10 (1992), S. 250-250 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] MIAMI—Delegates were forced to confront the reality beyond the technology in taking on the daunting topic of this year's Miami Bio/Technology Winter Symposium, “Feeding the World in the 21st Century.” In the preamble to his talk, for instance, John Sanford of Cornell University ...
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    Nature biotechnology 10 (1992), S. 251-251 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] MIAMI—Both the Commission of the European Communities (EC, Brussels, Belgium) and the U.S. Food and Drug Administration (FDA, Bethesda, MD) will bring out major new proposals on novel-food legislation in the next few weeks, and neither has ruled out absolutely the labeling of genetically ...
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    Nature biotechnology 10 (1992), S. 343-343 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Over 30,000 of them have been identified, with a bewildering range of shapes and sizes and a rich variety of biological actions. Many more are being described week by week, in organisms both familiar and arcane. They have no known roles in the internal economies of their producing cells, and the ...
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    Nature biotechnology 10 (1992), S. 264-267 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Sepsis (or toxic shock) is the most common cause of death in the medical-surgical intensive care unit. Mortality rates range from 40 percent (for early-phase sepsis) to more than 90 percent (for refractory septic shock)1. Despite its rapidly rising incidence, septic shock remains hard to diagnose ...
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    Nature biotechnology 10 (1992), S. 281-282 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Are you tired of filing applications for academic research grants? Do you resent being excluded from your large company's decision-making processes? Why not start your own biotechnology company? You're positive that your work in molecular biology, biochemistry or whatever will yield tests, ...
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    Notes: [Auszug] As a first example of the feasibility of producing industrial bulk enzymes in plants, we have expressed Bacillus licheniformis α-amylase in transgenic tobacco, and applied the seeds directly in starch liquification. The enzyme was properly secreted into the intercellular space, and maximum ...
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    Notes: [Auszug] We have obtained transgenic tobacco plants that express a barley ribosome inactivating protein (RIP) under control of the wound-inducible promoter of the potato wun1 gene. R0 transformants selected on kanamycin were tested for growth in soil inoculated with the soil-borne phyto-pathogen Rhizoctonia ...
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    Nature biotechnology 10 (1992), S. 320-320 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Columns. Phenomenex (Torrance, CA) presents Rezex HPLC columns for analyzing all types of carbohydrates, alcohols, and organic acids. Physiological fluids and cell cultures can be quickly analyzed for organic acids, amino acids, and carbohydrate levels. Various proteins, such as glycoproteins, can ...
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    Nature biotechnology 10 (1992), S. 111-111 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] “The science and technology of releasing genetically modified organisms into the environment, and the associated techniques of risk assessment, have now well and truly arrived,” said John Lake, Director of the European Environmental Research Organization (EERO), recently at Wageningen ...
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    Nature biotechnology 10 (1992), S. 120-120 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] IRVINE, Calif.—Researchers from companies and universities stepped up their outcry against a recent move by the National Institutes of Health (NIH, Bethesda, MD) to patent complementary DNA (cDNA) sequences derived from fragments of human genes isolated by researcher Craig Venter of the ...
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