Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Nature Publishing Company  (430)
  • Munksgaard International Publishers  (78)
  • Springer-Verlag  (12)
  • 1990-1994  (520)
  • 1970-1974
  • 1955-1959
  • 1992  (520)
Collection
Years
  • 1990-1994  (520)
  • 1970-1974
  • 1955-1959
Year
  • 1
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The cleaning effectiveness of different treatment methods for titanium abutments was evaluated using scanning electron microscopy (SEM). In the mandible of 4 beagle dogs, 25 titanium abutments were installed (modum Brånemark). After 16 weeks of plaque accumulation, mineralized deposits had formed on 23 abutments. Each of these abutments was subjected to one of the following treatment methods: scaling with (1) metal, (2) plastic, or (3) ultrasonic instruments;(4) air-polishing, (5) weekly rubber cup polishing or (6) daily brushing with a conventional toothbrush. Fourteen abutments were removed immediately after treatment. On 9 abutments, the scaling procedures and air-polishing were repeated after another 16 weeks of plaque accumulation. The abutments were prepared for SEM, and each of them was viewed and photographed at 3 different magnifications. The photomicrographs were evaluated by 3 examiners who, guided by reference pictures, gave each abutment a “cleanliness” score, ranking from 0 to 5. Regular rubber cup polishing and regular brushing resulted in the highest surface cleanliness, while the air-polishing procedure showed the lowest cleanliness score. None of the 3 scaling methods created a cleanliness score better than 3. The 3 scaling methods were considered equal in their cleaning effectiveness. No differences could be observed between surfaces treated 1 x or 2 x Taken the present findings and those of other studies concerning the effects of scaling on the surface roughness and biocompatibility into consideration, it was concluded that plastic scalers may be the instruments of choice for debridement of titanium implant surfaces.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Speech may be affected by the transition from complete dentures to fixed prosthesis on osseointegrated implants (OIB). If so, is there any correlation between interdental spaces (open or closed) in the prosthodontic construction and deteriorated speech? 21 individuals advocated for maxillary OIB were randomised so that one half of the group got constructions with wide interdental spaces and the other half with minimised inter-dental spaces. All patients were examined audiologically and their speech was individually tape-recorded before and after treatment. Perceptual, acoustic, model and audiological analyses were made. Approximately 60% of the patients were judged to have indistinct speech after the treatment. The s-sound was perceptually and acoustically distorted. 67% of the patients suffered from hearing defects. No correlation between interdental spaces (open or closed) and deteriorated speech could be found. It is supposed, that hearing plays a part in the effort to adjust speech to a new maxillary OIB, and thus reduced hearing can enhance speech difficulties.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The installment of endosseous dental implants has become an accepted treatment procedure, and the long-term clinical results appear excellent. The composition of the soft tissue environment, however, is different from that around natural teeth. One characteristic of original junctional epithelium is its association with plasminogen activator (PA) activity. In 11 patients with a total of 30 IT1 hollow-screw titanium dental implants, 16 biopsies were taken. Histologic cryostat sections were assayed for the presence of PA in the junctional epithelium. The results demonstrated that junctional epithelium around titanium implants yields PA activity in a manner very similar to that of natural teeth. The ability to produce this enzyme activity is not related to the developmental origin of the junctional cells, but to their position and function at the base of the gingival sulcus.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The microflora around titanium implants and teeth in 4 beagle dogs was analyzed in order to follow the longitudinal development from healthy conditions to experimental gingivitis and periodontitis. A 2-month plaque control program was performed to establish healthy conditions on titanium implants and control teeth (baseline, day 0). Subgingival bacterial samples and radiographs were obtained. The plaque control was ceased and all measurements were repeated on day 21 (gingivitis). A new period of plaque control was initiated to re-establish healthy conditions (day 49). A cotton ligature was placed subgingivally around the implants and the control teeth to induce tissue breakdown. The ligatures were removed on day 91. The study was completed with registrations on day 121 (periodontitis). No significant microbiological difference was found between titanium implants and teeth in healthy conditions and in gingivitis and periodontitis. The mean total viable count increased 10 times on implants as well as on teeth. Streptococci were dominating at baseline: 40.2% on implants and 60.6% on teeth and decreased in gingivitis to 11.7% and 5.4%. When periodontitis had developed, the proportion of streptococci was 〈 1%. At baseline few Porphyromonas gingivalis and Prevotella intermedia were detected. They increased at gingivitis to 37.4% and 21.0%; when periodontitis developed, they comprised about 25.0%. Microbial colonization and establishment on titanium implants with healthy gingiva, experimental gingivitis and periodontitis follow the same pattern as on teeth.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An intimate contact between bone and titanium implants was first demonstrated in 1969. and since then the bone-implant interface of osseointegrated implants has been investigated extensively. However. investigations of the marginal tissues and the microflora associated with osseointegrated implants have almost exclusively been carried out over the last decade. This review covers the clinical, radiographic, histologic, and microbiologic studies of marginal tissues of osseointegrated oral implants. In general, successfully osseointegrated implants exhibit low amounts of plaque con-comitant with the absence of marginal inflammation. However, plaque accumulation may cause inflammatory reactions around the implants, sometimes giving rise to mucosal hyperplasia. Apparently, keratinized mucosa is not a requisite for the maintenance of peri-implant health if oral hygiene is adequate, but the presence of peri-implant keratinized mucosa is generally advocated. Alveolar bone loss around successful implants is minimal, but significant focal loss may occur due to plaque-induced inflammation or perhaps repeatedly extensive implant load. The progression of plaque-induced alveolar bone loss of osseointegrated implants may be different from that of teeth. It is unknown whether simultaneous marginal inflammation and excessive implant load further increase the loss of alveolar bone height. Both the light microscopic and ultrastructural characteristics of marginal tissues of implants and teeth are similar except for a lack of root cementum with inserting gingival collagen fibers of implants. Clinical inflammatory reactions are histologically characterized by an increased number of inflammatory cells infiltrating the connective tissue. The scattered subgingival microbiota associated with osseointegrated implants surrounded by healthy or slightly inflamed marginal tissues is similar to that of teeth with healthy gingiva. The microbiota associated with implants affected by marginal inflammation and bone loss is complex and consists predominantly of gram-negative anaerobic rods: this. again, is a similarity to periodontal disease.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eight non-submerged titanium implant screws were placed in the first upper molar edentulous sites of monkeys and subsequently kept loaded with single crown prosthesis 1 month following implantation. The animals were killed after a further 14 months and specimens including implant and adjacent teeth were processed for light and electron microscopy. Histological pictures of all samples showed the neck and most of the screw body to be surrounded by new bone. The soft tissue surrounding the implant post included pocket epithelium and supra-crestal connective tissue displaying collagen fiber bundles comparable to gingival ligaments. These peri-implant collagen fiber bundles arose from the neighboring alveolar crest, root cementum of adjacent teeth or, superficially, from the epithelium and followed a circular array around the implant neck.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to investigate the possibility of antimicrobial treatment of peri-implant infections associated with a periodontitis-like subgingival microbiota. Nine partially or fully edentulous patients with titanium hollow cylinder implants were selected which showed loss of bone and probing depths ≥ 5 mm on one or several implants after at least 6 months following installation. They also yielded subgingival microbial samples with ≥ 106 CFU/ml, including ≥ 20% gram-negative anaerobic bacteria, The treatment included mechanical cleaning, irrigation of all peri-implant pockets 〉 3 mm with 0.5% chlorhexidine and systemic antimicrobial therapy (1000 mg ornidazole for 10 consecutive days). After therapy, bleeding scores decreased immediately and, over a one-year observation period, remained significantly lower than before treatment. A significant gradual reduction in mean probing depths was detected over this one-year period; only one case showed no improvement of local probing depth. Microbiological parameters indicated an instantaneous quantitative and qualitative change following treatment. Subsequently, several of these parameters tended to shift back towards pre-treatment values. In the second half of the observation period, however. this tendency was reversed, and levels significantly different from baseline were eventually established. This study demonstrated that treatment aiming at reducing the subgingival bacterial mass and suppressing the anaerobic segment had a beneficial effect in patients suffering from peri-implantitis.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several parameters have been described to determine success or failure in long-term evaluations of dental implants. One of these parameters is the observation of changes in peri-implant bone levels. Studies on submerged implants have analyzed the bone level changes in the pre- and post-loading phases. No such data exist for intentionally nonsubmerged implants. The purposes of this study were: (1) to test the applicability and reproducibillity of a simple computer-assisted method in the evaluation of changes in peri-implant bone levels;(2) to establish a baseline for the longterm radiographic follow-up; and (3) to evaluate changes in crestal bone levels adjacent to nonsubmerged IT1 implants between the 1-year and 2-year examination. Standardized periapical radiographs were obtained from 80 implants at the l-year and 2-year follow-up examinations after their placement. The implants were located in different jaw areas of 55 patients and supported single crowns or short-span fixed partial dentures. For each implant, the distance from implant shoulder to first crestal bone contact (DIB) was measured at the proximal surfaces with a digitizer/computer assembly. Statistically significant greater mean DIB were found at the l-year (baseline) evaluation for: (I) maxillary sites overall (4.10 x 1.02 mm (SD)) compared with mandibular sites overall (3.61 ± 1.03 mm);(2) maxillary anterior sites (4.08 ± 0.97 mm) compared with mandibular posterior sites (3.60 ± 1.05 mm); and (3) maxillary posterior sites (4.13 ± 1.12 mm) compared with mandibular posterior sites. No statistically significant changes in DIB occurred in any of the jaw locations between the l-year and 2-year evaluations. These results indicate similar changes in peri-implant bone levels for non-submerged implants over a 2-year period 1 as reported for submerged fixtures.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this research was to determine the nature of the residual hydroxyapatite (HA)-coated implant surface after treatment with various chemotherapeutic modalities, including: citric acid, chlorhexidine gluconate, hydrogen peroxide, tetracycline HCl, stannous fluoride, polymyxin B and a prototype plastic Cavitron tip. Implant surfaces were evaluated macroscopically, microscopically (scanning electron microscopy (SEM)) and spectrometrically (energy-dispersive spectrometry and X-ray diffraction). HA-substrate bond strength and dissolution testing was also performed for surfaces treated with a supersaturated citric acid solution. All treatments left either microscopic residues or a loss of surface roughness when viewed on SEM. A 30- to 60-s application of citric acid left a significantly greater coating thickness than all other treatments, whereas a 3-min application of citric acid removed significantly more HA than untreated controls. Significant changes in CaiP ratios were seen with most treatments. The clinical significance of this phenomenon is not known. No treatments altered the crystallinity of the residual HA coating. A l-min application of citric acid did not significantly alter the tensile bond strength of the coating to the substrate. The clinical significance of these findings is not known at present. However. when taken with results from previous studies. it appears that in treating the infected HA-coated implant surface, a 30- to 60-s application of citric acid (pH 1) may be beneficial in detoxifying the HA coating prior to regenerative procedures. Further in vitvo and in viva studies are necessary to evaluate the biological response to citric acid when used to detoxify the infected implant surface.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The experiment was performed to evaluate the effects of long-standing plaque on the gingiva and peri-implant mucosa. 5 beagle dogs were used in the study. The mandibular right premolars were extracted. 3 months later, 3 titanium fixtures were installed and after another 3 months, abutment connection was performed. Plaque control, in the implant as well as the contralateral tooth regions, was maintained during a 4-month period prior to the start of the main experiment. On Day 0, the teeth and implant sections were examined with respect to plaque and gingivitis. The plaque control program was terminated. The animals were subsequently fed a diet which allowed gross plaque accumulation. After 90 days of undisturbed plaque formation, the dogs were re-examined and biopsies harvested from implants and contralateral teeth. On day 90, all teeth and implants had accumulated large amounts of plaque. The soft tissue at implants and teeth bled on gentle probing. The histological examination of the gingiva and the peri-implant mucosa revealed:(i) both tissues contained an inflammatory cell infiltrate; ICT, (ii) the apical extension of ICT was more pronounced in the peri-implant mucosa than in the gingiva and (iii) the composition of the 2 lesions had many features in common.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 11
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been documented that the long-term clinical outcome of the Brånemark® system is very favourable. However, failures do occur before and after loading. This study examined the differences in marginal bone loss between standard and self-tapping fixtures and attempted to explain excessive marginal bone loss or loss of osseointegration during the first 3 years of loading. Marginal bone loss (scored on long cone radiographs) and fixture failure rate were compared for different fixture designs. For standard fixtures, in comparison with self-tapping fixtures, the failure rate was clearly higher before as well as after loading. However, for successful fixtures no difference in marginal bone loss was observed. For the conical fixtures an increased marginal bone loss around the smooth part was observed. The effect of fixture overload, marginal bone height and loss of osseointegration was examined in 69 patients with 1 and 15 patients with 2 fixed full prostheses, and in 9 patients with an overdenture in the upper jaw. Excessive marginal bone loss (more than 1 mm) after the first year of loading and/or fixture loss correlated well with the presence of overload due to a lack of anterior contact. the presence of parafunctional activity and osseointegrated full fixed prostheses in both jaws.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 12
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to improve the prosthetic versatility of the ITI-Bonefit implant system, a clinical technique was tested whereby a custom made post and core buildup was cemented into implants. Specially designed threaded and serrated posts were machined in precious metal. After the posts were seated into the threaded channel of the implants, cores were built using autopolymerizing resin. Those were then cast and cemented into the implants. For the remainder of the procedure, the buildups were treated like natural abutments using conventional prosthodontic techniques. Mechanical tests were performed to assess the clinical viability of these buildups. The ultimate tensile strength of annealed posts lies in the 700–800 N range. By comparison, the pull-out resistance of posts cemented into natural roots ranged between 108 and 177 N, and the maximum pull-out resistance of manufactured abutments is about 1040 N. When the resistance against lateral forces was tested, the cemented build-ups ranged between 981 and 1128 N. whereas natural teeth fractured between 206 and 903 N depending on the diameter of the root. Manufactured abutments failed at stress levels of about 1020 N. Considering these favorable results, we conclude that the technique described above can be applied clinically for further investigation. Additionally, we suggest some modifications in implant design that would enhance the versatility of the system.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 13
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to test whether healing of extensive transosseous defects in the calvaria can successfully be achieved using guided bone regeneration. The results demonstrated complete osseous bridging of the skull defect in the test specimen. In the control specimen, fibrous connective tissue occupied the area of the skull defect.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 14
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: For several years, osseointegrated implant-supported overdentures have been used in the rehabilitation of full edentulism with excellent results, at least in the lower jaw. This study involved 3 groups of patients with different prosthetic reconstructions:(1) mandibular overdentures supported by 2 implants connected by a bar (30 patients), (2) mandibular fixed prostheses supported by 4–6 implants (25 patients) and (3) mandibular complete dentures without implant support as controls (85 patients). The primary aim of this study was to examine on orthopantomograms (by means of the area index to minimize distortion and magnification errors), posterior mandibular ridge resorption in the 3 treatment groups. The present data demonstrated a minimal posterior mandibular ridge resorption in patients with fixed implant-supported prostheses. A more considerableposterior ridge resorption was observed in the complete denture group and especially in the overdenture wearers. For the latter, the annual posterior jaw bone resorption after the post-extraction remodeling period of 6 months, was 2- to 3-fold that of full denture wearers. When patients were edentulous for more than 10 years, the difference between the 2 latter groups disappeared. It is suggested that although the overdenture design on 2 implants offers advantages from a financial and failure rate point of view, its indications in younger patients should cautiously be evaluated in a long-term perspective concerning posterior mandibular bone resorption.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 15
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of the present investigation was to assess the effect of de novo plaque formation on the gingiva and masticatory mucosa around teeth and implants. The study was performed in 5 beagle dogs which at the initiation of the experiment were 15 months old. During a preparatory period, the mandibular right premolars were extracted, 3 fixtures installed, abutment connection performed and a 4-month period of plaque control completed. A clinical examination was performed and biopsies of the second mandibular premolar (Pz) and the contralateral implant site (2P) were sampled. The dogs were allowed to form plaque during a period of 3 weeks. The clinical examination was repeated and biopsies harvested from the 2 remaining implants and the contralateral tooth sites. The tissue samples were prepared for histometric and morphometric analysis. Both the masticatory mucosa at implants and the gingiva responded to de novo plaque formation with the development of an inflammatory lesion. The size as well as the composition of the lesions in the 2 tissues had many features in common. It was concluded that the mucosa around implants and the gingiva around teeth had a similar potential to respond to early plaque formation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 16
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to develop a repeatable method for measurement of bone support around root form and blade implants suitable for use in high-quality but unstandardized radiographs. 10 phantoms were fabricated to simulate progressive osseous defects around implants. Radiographs were taken in triplicate and digitized. Specialized software was written which placed a grid of known dimensions over the implant so that the top and the bottom of the grid were at the neck and the base of the implant, respectively. The investigators selected the edge of the bone at each point where the grid intersected the implant and the software automatically detected the implant edge. The software also outlined and displayed the defect on the computer monitor. Measurements were performed 5 times and the standard deviation was taken as a measure of the repeatability of the method. Repeatability for blades and root forms was 0.19 ± 0.07 mm and 0.08 ± 0.03 mm, respectively. There was no significant difference in the ability to measure bone loss in the blade versus the root form (pequals;0.17, NS). These results indicate that this semi-automated computer-assisted method for measuring bone loss around implants is repeatable and may be of value for clinical trials using either root form or blade implants.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 17
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: This report derives an exact, but practical, expression for calculating the stack effect from air densities and leakage distribution using the power law formulation of envelope leakage. The neutral height-the height at which there is no stack-related indoor-outdoor pressure difference-is a key intermediate in stack modeling. This report defines a computable parameter called stack height, which contains all of the leakage distribution information necessary for estimating stack flows, thus freeing the model from specific assumptions (e.g. that the leakage is separable into evenly distributed floor, wall, and ceiling components). Example calculations, including comparisons with other models, as well as validations using measured data from dwellings, are also presented. The dimensionless neutral level, which is related to the neutral height, is often used as an indicator of leakage distribution and in superposition. Its definition and role in these instances are discussed in detail. The more exact formulation is then used to analyze the simple box cases normally assumed in infiltration modeling and other approximations. Measured ventilation data will be used to infer leakage distributions and neutral levels as well as for example calculations.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 18
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: The vertical temperature profiles have been measured in a full-scale office room ventilated by displacement. Different wall radiative emissivities have been employed to study the effect of thermal radiation. The change of the vertical locations of the heat source does not affect the stationary front, but modifies the temperature profile.Two new nodal models, i.e. a four-node model and a multi-node model, are developed for predicting the temperature profile based on the flow and thermal characterization in the room. Agreement between the models and the experiments are very good. The calculated results are applied to show that the temperature profile is influenced considerably by the heat conduction through the walls and the thermal radiation between the wall surfaces. The models developed can be used for design purposes, as well as to supply the thermal boundary conditions in a CFD code.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 19
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 20
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: The indoor air quality (IAQ) programme of the World Health Organization Regional office for Europe was initiated in the mid-seventies when it was realized that over 70% of the general population spends its time indoors in homes, office buildings, schools, hospitals, transportation means, etc. The first meting of experts on health aspects related to IAQ was convened in 1979, being probably the first international meeting on IAQ with participation from eastern and western Europe as well as from North America. Seven meetings followed between 1982 and 1990, at which the “sick building” syndrome, IAQ research, formaldehyde and radon, organic pollutants, biological contaminants, combustion products, and mineral fibres were discussed. A ninth meeting on sources, control and mitigation is planned for 1991.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 21
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: In order to cumpare the peformance of different supply diffuers of ventilation air, the airflow passern, temperature stratifiation and contaminant dispersion in a furnitured office ventilated by three kinds of air diffuer were numerically investigated. The air diffuers studied in this paper are a quarter-cylinder displacement diffuer on the floor and mixing diffuers (linear and vortex diffuers) on the ceiling. The heat sources in the of-fice are considered to be 50% convective and 50% radiative. The k-ɛ two-equatwn model of turbulence is employed to predict the turbulent diffusion.The results show that the displacement diffuser provides a rather uniform flow field with low velocify in most areas, and the vertical temperature difference from floor to ceiling is as high as 6 K. With the linear diffuser, the air velociry is high, and the temperature is uniform both horizontally and vertically. The air velocity generated by the vortex diffuser is moderate. The distributions of the temperature and the contaminant are rather uniform.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 22
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: Residual airborne concentrations of methyl bromide (MB) were measured in 10 houses after fumigation with MB at a mean exposure of 53, 369 ppm. hr to control drywood termites. Sulfuryl fluoride (SF) residues were measured in 10 and 3 houses after SF fumigation at 59,161 and 33,531 ppm. hr, respectively. Prior to sampling, all 23 houses were aerated to MB and SF threshold limit values (TLVs) of 5 ppm following label-directed procedures. Immediately following aeration, doors and windows of houses were closed and ventilation system deactivated. During this initial 2-h closure period, the mean concentration among MB-fumigated houses increased to 17.5 ppm MB at 90 min with room means of all 10 MB houses exceeding TLV. Residue means at 120 min among SF-fumigated houses were 4.6 and 5.0 ppm SF with 3 and 2 houses exceeding TLV for the high and low SF exposures, respectively. After a second aeration and closure, levels exceeded TLV in 5 of 6 MB houses monitored during this period, but not in any of the 9 SF houses sampled. Post-aeration residues tended to be higher in bedrooms and bathrooms. Because of the excessive transient desorption and diffusion of both fumigants revealed by this study, modified aeration procedures are needed to ensure that occupant exposure levels do not exceed safety standards.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 23
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: Indoor air bacteria and fingal spore levels were studied in 71 non-complaint homes. lk data were analyzed according to the season and the higher limit of the range within which 95% of the cases fall was computed. On the basis of the data the following highest normal levels are proposed for winter: for bacteria 5000 cfulm3 and for fingal spores 500 cfulm3. The recommended levels apply in a subarctic climate for urban and suburban homes when the measurements are made using the same method as in this study. We recommend that if abnormal indoor sources are suspected, indoor samples should be taken in winter when the ground is frozen and covered with snow. At that time, the background levels are at their lowest and the abnormal indoor sources are most easily detected. lk recommended levels should not be used as an indicator of a health risk, but as an indication of abnormal indoor sources or insufficient ventilation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 24
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: Indoor carbon dioxide (CO2) concentration can be used to estimate the degree of air recirculation and outdoor air supply rate. Three types of CO2 detector tubes were evaluated by using Fourier Transform Infra-Red (FTIR) Spectroscopy as a reference method. Two types of detector tubes (Draeger CH 30801 and Kitagawa 126 B) showed a good correlation with the reference method (r = 0.98), the 95% confidence interval of the slope being 0.89-1.06 and 0.80-0.95, respectively in linear regression analysis. The third type (Gastec 2LL.) showed lower correlation (r = 0.91) and a wider 95% confidence interval (0.52-0.80) of the slope. A t CO2 concentrations in the range 800-1000 5 l/l(ppm), control values suggested for the indoor environment, the Draeger and the Gastec tubes underestimated the CO2 concentration, while the Kitagawa tube showed a correct value. The difference in reading between observers was similar for all three brands of detector tubes (5-7%), expressed as relative standard error No significant influence of the air humidity or temperature on the readings could be demonstrated. It is concluded that some brands of CO2 detector tubes can be used to measure indoor carbon dioxide concentration with sufficient precision and accuracy. Since the relative error is relatively large at lower CO2 concentrations, the use of such tubes for the determination of air recirculation in ventilation systems should be avoided. As a crude estimate of the outdoor air supply rate, however, CO2 detector tubes may be used. In order to minimize the error in reading, the type of detector tube and the need for recalibration should be considered. When using CO2 measurements as an estimate of outdoor air supply rate, the influence of age and work-load on the individual's emission of CO2 and the time needed to reach equilibrium, should also be taken into consideration.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 25
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: Where indoor concentrations are high, radon entry into houses with basements is usually due primarily to the convective transport of soil gas through openings in the subsurface part of the building shell. The factors determining the rate of entry may conveniently be divided into those associated with the undisturbed soil and those associated with the structure and its surroundings. This paper uses a numerical model to determine the influence of the latter factors on the soil gas and radon entry rates. The most important of these is the presence or absence of a gravel layer below the slab; the presence of the gravel can increase the radon entry rate through the perimeter gap betureen the foundation footer, slab, and wall (slab-footer gap) by as much as a factor of 5 over that for homogazeous soil. The permeability of the gravel becomes important when the soil permeability is unusually high, i.e., greater than 10−10 m2. Of lesser importance are the thickness of the gravel layer and the radium content of the gravel. The sizes and numbers of openings in the slab are relatively unimportant so long as the total opening area is vey small compared to the slab area. If cracks in the basement walls are major radon entry paths, as in concrete-block construction, the permeability of the soil restored to the region adjacent to the walls after completion of construction (backfill) is the determining factor in convective radon entry through these openings; if the soil is packed loosely, so that there is a gap between wall and soil, radon entry through a wall crack may be further increased by as much as a factor of 7.5. Radon entry rates through the slab-footer gap and through openings in the slab are only weakly influenced by the permeability of the backfill. The resistance of the perimeter gap to soil gas entry becomes significant when the gap width falls below 0.001 m, assuming a soil permeability of 10−11 m2.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 26
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: A six-week study of indoor and outdoor air pollutants was conducted in central New Jersey during the summer months of 1989. Three institutional settings for elderly and child care were investigated for the potential of acidic aerosol exposures. The indoor penetration by fine aerosols was 〈 70% at all three institutions. For locations with closed ventilation, it was 15-25% lower than for the open-window setting. Relative to outdoor levels, indoor acidic sulfate aerosols were 30-57% neutralized. Indoor levels of ammonia were = 10 × higher than corresponding outdoor values, which were consistent with calculated emission rates from human occupants. From estimates of total daily exposure, 75% of the daily dose of aerosol acidity for the elderly was due to indoor exposures. Doses received by the elderly and children ranged from 290 to 1100 nmoles of acid (15 to 55 ug as H2SO4) in a 24—h period with “worst-case” dose received by children as high as 3400 nmoles of acid in the daytime. These doses were comparable to the levels observed in clinical and epdemiological studies where health effects result. The daily dose of acid delivered to children was calculated to be 2 to 4 × higher than the dose to the elderly population. The calculations for children indicate that more than 90% of their dose on a summer day may come from outdoor exposures. These data suggest that indoor settings are protective, but children may still be at risk from summertime acidic aerosol exposure, depending on their activities outdoors.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 27
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: The main source of high radon concentration indoors is the exhalation of radon from the soil. In the western part of Germany, two interesting regions, “Eifel” and “Hunsrück”, are selected for these radon investigations. The first region is an area with silt and sandstone of low uranium content but with tectonic fractures caused by postvolcanic activity, whereas in the part of the “Hunsrück” under consideration, the uranium concentration in the ground formerly allowed the extraction of uranium ores. An electrostatic deposit of the first radon daughter (Polonium-218-ion) onto a surface barrier detector and the subsequent analysis of the measured alpha spectra enables the determination of the concentration of radon in dwellings, its diffusion through and its exhalation rate from the soil. A maximum indoor concentration of radon of 8 kBq★m−3 in a bedroom and approximately 35 kBq★m−3 in a cellar room were determined in a house built in 1976. The daily variation between the minimum and the maximum concentration indoors amounts to a factor of ten. In these regions the radon concentration outdoors varies between 20 and 150 Bq★m−3. The exhalation rates of radon from the soil are found to range from 0.002 to 1 Bq★m−2★S−1 The effects of sealing the ground slab with polyurethane and removing the air under the ground slab by suction will be presented.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 28
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: This paper is based on field measurements in auditoria, carried out in Norway and in Switzerland. In both cases carbon dioxide (CO2 was chosen as the relevant indicator to establish ventilation demand.Investigations in Norway focus on the aspects of airflow, patterns, ventilation efficiency and air quality. Intensive monitoring and numerical calculations with the computer code KAMELEON were performed.The Swiss project places more emphasis on impacts of demand control on energy consumption and occupant response. The results of the fild measurements, of the questioning of occupants, as well as of simulations which were carried out with the simulation code TRNSYS are presented.Results show that demand control with CO2, as indicator for ventilation demand can maintain an acceptable indoor climate while allowing substantial energy savings.These investigations were conducted as part of the IEA (International Energy Agency) research programme “Annex 18: Demand Controlled Ventilating Systems”.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 29
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: The TVOC summation of masses of non-reactive substances has often been used as a practical way of reporting environmental measurements of volatile organic compounds. This total concentration, moreover, is often used as an indication of the potential of a multiomponent atmospheric pollution with substances of low chemical reactivity to cause chemically induced sensory irritation. This use of the TVOC indicator has never been standardized. Various authors have used different measuring techniques and the results have been used to predict certain types of health effect. This article discusses the toxicological background for the TVOC concept in relation to nonspecific sensory irritation and identifies some theoretical limitations in its use within this context. The TVOC indicator of nonspecific sensory irritations should be based only on a limited range of compounds and should be interpreted as a lower limit of the possible intensity of sensory irritation. Based on the discussions, some precautions are recommended with respect to measurements of TVOC and interpretation of the measurements.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 30
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: Air cleaning as a means of mitigating the risks arising from exposure to indoor radon progeny has been evaluated in a single-family house in the north eastem US. using an automated, semi-continuous activity-weighted size distribution measurement system. The measurements included radon concentration, condensation nuclei count, and activity-weighted size distribution of radon decay products. Measurements were made in the house with and without an operating air filtration system and with various particle sources common to normal indoor activities operating. Aerosols were generated by running water in a shower, candle burning, cigarette smoking, vacuuming, opening doors, and cooking. Using a room model, the changes in attachment rates, average attachment diameters, and deposition rates of the unattached fraction with and without the air cleaning system were calculated. In the presence of active aerosol sources, the air filtration unit typically reduced the concentration of particles within the hour following the end of particle generation. After candle burning, cigarette smoking, and vacuuming in the bedroom, the reductions of PAEC by air filtration are about 60% with the air filtration system operating in the bedroom. During cooking in the kitchen, the reductions of PAEC in the bedroom with the air filtration system were about 40%. However, for all cases the dose reductions were smaller than the particle and PAEC reductions. For those particles that were generated within the bedroom, there was a 20% to 50% reduction in dose. In the case of cooking where the door was open and particles infiltrated from the rest of the house, the dose reduction was only 5% on average and appears to be insignificant. Thus, the dose reductions were h e r than the reductions in activity concentration, but there were no cases where the estimated dose actually increased.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 31
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: The paper presents the results of preliminary investigations on the applicability of commercial polyethylene films to permeation-type passive samplers for the preconcentration of organic indoor air pollutants. The samplers were calibrated in exposure chambers in the atmosphere of standard gaseous mixtures containing vapours of m-xylene, styrene, m-dichhobenzene and cyclohexanone – volatile organics often encountered in indoor atmospheres. The permeation rates remained constant for all the film in the entire investigation period (9 months). Of the materials examined, the most suitable proved to be Cryovac EFDX 003 (28 μm), ensuring the highest permeation rates.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 32
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: A total of 115 Danish dwellings were investigated during the winter season in order to evaluate the indoor environment. The sample was considered representative of Danish dwellings. Measurements of air-exchange rates in the bedrm showed a very low natural venthtion with a median air-exchange rate of 0.28 air changes per hour (ach) (interqmmle range (IQR): 0.12 –0.56).18% of the dwellings had a natural air-exchange below a detectable limit of 0.10 ach and 72% had air-exchanges rates below the requirements in Danish Building Codes of 0.50 ach. The investigations showed a statistically signifiant inverse correlation between air-exchange rates and absolute indoor humidity. Concentrations of formaldehyde and volatile organic compounds were measured in 36 dwellings. The median formaldehyde concentration was 0.037 mg/m3 which is well below the recommended indoor TLV The concentration of VOC in some cases reached a level that may be of importance for persons with sensitive airways. It is concluded that natural ventilation in a great number of Danish dwellings is too low fiom a health point of view and that the requirements in Danish Building codes are insufficient to ensure acceptable air-exchange rates.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 33
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: Two models, one physical and the other empirical, have been applied to the characterization of emission data of thin film products tested in small environmental chambers and have been compared in temts of emission results and m e of use. The physical model, being based on equations with coefficients bearing a physical meaning, is, in principle, more informative than the empirical one. However, it is uncertain whether it always gives accurate and unambiguous results. Moreover, in orakr to be exploited in a reasonable amount of time, it requires the use of non-linear regression routines, e.g. those fom SAS Institute Inc., implemented on mainframes and, even then, it is often quite diffiult to handle. The empirical model does not rely explicitly on physical effects. Although by definition it can only describe but not interpret the experimental data, it does estimate parameters describing the emission with an accuracy comparable to that of the physical model. It is easier to handle than the latter as it can employ non-linear regression routines such as those used on personal computers.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 34
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Potato plants transgenic for the coat protein (CP) gene of potato virus Y strain N (PVYN) were examined for the accumulation of the transgenic PVYN CP. The protein remained undetectable in healthy plants of lines Bt6 and Bt10 that are completely or partially resistant to this virus, but accumulated ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 35
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 1045-1046 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Flask. A new culture flask from Corning Science Products (Corning, NY) has a vented cap that helps protect cells while maximizing cell growth. It is ideal for all cell cultures that are sensitive to contaminants. There is a .22-m membrane in the cap that ensures against constant gas exchange and ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 36
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 936-937 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Stephen Edgington's article, “Biotech Vaccines' Problematic Promise” [Bio/Technology 10:766 (1992)] was generally informative, but his discussion of FDA's regulation of vaccines was inaccurate and confusing. Edgington is muddled on what applications must be submitted to ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 37
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 940-945 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] •The U.S. Food and Drug Administration (FDA, Bethesda, MD) and the drug industry are near an agreement regarding user fees to speed up the drug approval process. Under the plan, FDA proposes that drug companies pay several fees: $150,000 for each drug application, regardless of whether ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 38
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 952-953 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] TOKYO?Milk has been described as the perfect food, but of course, it's not. Neither are beef, tofu, corn, or wheat. In fact, no food is—unless it could be modified to supply the amino acids, minerals, vitamins, and fibers that it lacks in its natural state. Enter biotechnology. Genetic ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 39
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 962-962 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Despite a general hiring freeze at the Food and Drug Administration (FDA, Bethesda, MD), Commissioner David Kessler says the agency will soon meet its promise of hiring 50 new staff members to review new biotech drugs. During a recent press briefing, Kessler also said that ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 40
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 963-966 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bio/Technology conducted its first reader compensation survey in 1988. Back then, the average reported compensation was in the $50,000-$60,000 range. This year, the average compensation is about $30,000 a year higher than that. The scope of the enterprise Bio/Technology's ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 41
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 973-980 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pharmaceutics is an honorable pursuit, but surely so ambitious it verges on the foolhardy. It attempts to tip the fine balance between human health and disease, both states complex and poorly understood, by administering low-molecular mass drugs—by molecular tweaking. First, consider that ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 42
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 993-996 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Oligonuclotide-based therapeutics hypothetically stand poised to reshape the pharmaceutical industry (see, for example, Bio/Technology 10:256–262, March 1992). At least 24 companies worldwide have dedicated a major portion of their resources to fighting everything from viruses to oncogenes ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 43
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 830-830 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Russ Hoyle's commentary, “Eating Biotechnology” (Bio/Technology 10:629, June), discusses the Food and Drug Administration's (FDA) policy for foods derived from new plant varieties, but mischaracterizes our policy in several important aspects—possibly because at the ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 44
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 833-833 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The negotiators have completed their task, and at long last we have a chemical weapons convention. All that remains to be done, after decades of logic chopping in Geneva, is for 65 nations to ratify the text. But that, of course, may take several more years. Only then, perhaps, will those nations, ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 45
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 846-847 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Early-stage biopharmaceutical stocks, essentially those companies that came public during 1991 and early 1992, have considerably underperformed more mature biotechnology stocks during the 1992 correction. At this point, the unattractive elements of these stocks to investors are severalfold. They ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 46
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 981-985 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the turn of the century, Alexis Carrel, the father of modern day tissue culture (see Bio/ Technology 10:855–860, August 1992) found that if he grew a tumor on a fibrous clot it lysed the clot, but normal cells grown on the same clot had no effect. Carrel suspected soluble factors from the ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 47
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 994-995 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As activity gears up for oligonucleotide therapies, companies devote additional resources to its promise. Nearly all companies make boiler-plate claims for their products: readily enter tissues and cells, are resistant to enzymatic degradation, have ideal targeting characteristics, and are ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 48
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 870-872 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Today's biotherapeutics must meets tringentpurity requirements—extraneous nucleic acids, viruses, endotoxins, host cell proteins, and additives from fermentation or cell culture media must all be removed from the product. It is also necessary to remove product aggregates, which are ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 49
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 830-831 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: PROSAMO (Planned Release of Selected and Modified Organisms) is a three-year plant and microbial research programme operating as a partnership between the U.K. government (DTI), AFRC, industry (a consortium often major biotechnology companies), and four leading academic research ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 50
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 831-831 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Figure 3 was inadvertently omitted from “Interactions in the Fourth Dimension” by Puss Granww and Robert Reed (Bio/Technology 10:399–393). The missing figure is reproduced below. FIGURE 3. The effect of amino acid changes in the Z domain of Protein A on the on-rate and off-rate ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 51
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 840-840 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Two gene-therapy proposals for combating HIV infections recently ran into virtually opposite receptions from different federal review committees. These cases— one involving the National Institutes of Health (NIH, Bethesda, MD) and the other the Food and Drug ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 52
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 843-843 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—As this year's second quarter ended, the record-shattering 1991/ 1992 public-financing window for U.S. biotechnology companies seemed to slam shut. So far, 132 biotech companies have raised $5.2 billion through stock offerings, including $2 billion through 64 initial ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 53
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 848-849 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Just before the United Nations Conference on the Environment and Development (UNCED) convened in Rio this past June, the Bush administration abruptly decided not to sign the so-called biodiversity treaty, an international convention to preserve the world's biological species. The move, widely but ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 54
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 864-865 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Technical advances have raised transgenic animal technology to the status of a cost-effective alternative for producing certain proteins. So does that mean that the challenge really facing this emerging industry is regulatory clearance? The U.S. Food and Drug Administration (FDA, Bethesda, MD) and ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 55
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 873-875 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human resource management— the art of employing, developing and managing people—is needed more, and needed earlier, in biotechnology than in perhaps any other sector. As human resources professionals in biotechnology we would say that, wouldn't we—but that does not mean it is not ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 56
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have engineered an industrial strain of the yeast, Candida tropicalis, for the efficient production of long–chain dicarboxylic acids, which are important raw materials for the chemical industry. By sequential disruption of the four genes encoding both isozymes of the acyl–CoA oxidase ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 57
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 916-917 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Disposable. From Microgon (Laguna Hills, CA) comes disposable membrane modules for fast, convenient, microporous separations. The membranes concentrate animal and microbial cells, separate cells from proteins, and wash cells or diagnostic particles to recover or remove large proteins. Membrane ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 58
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 921-921 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Line. Shimadzu Scientific Instruments (Columbia, MD) presents its 32-page catalog outlining an extensive line of chromatography, spectroscopy, environmental, and physical testing instrumentation offered in North America. The catalog features the recently introduced LC-10A Series HPLC system. Write ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 59
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 717-717 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An old friend writes to suggest a “paean to FDA's food biotech policy”: The U.S. Food and Drug Administration's May 29 Statement of Policy: Food Derived from New Plant Varieties is “scientifically sound ⃜ riskbased⃜ workable…[and] safeguards the public ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 60
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 728-730 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—U.S. companies have slashed research and development (R&D) spending. Largely because of a weak economy and industrial consolidation, annual real growth in industrial R&D outlays slowed to 1.5 percent between 1985 and 1990. In 1991 company research spending probably didn't ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 61
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 736-736 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Scios's (Mountain View, CA) proposed purchase of Nova Pharmaceuticals (Baltimore, MD) for $180 million in stock opened to mixed reviews, generating as much criticism as praise. Criticism was strong. “The combined company still lacks the critical mass to fully develop ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 62
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 740-741 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The U.S. Food and Drug Administration (FDA, Bethesda, MD) announced its policy for foods derived from genetically modified plant varieties, reaffirming that such foods will be judged on their characteristics, not on how die plant genes may have been manipulated. The ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 63
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 748-748 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SANTA CRUZ, Calif.—No more cardboard tomatoes. Consumers may be able to buy tomatoes from their grocer that are as good as what they could grow in their back yards: plump, juicy, red, and tasty. But these aren't Big Boys. They're probably Flavr Savrs or some other genetically manipulated ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 64
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 754-754 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the moment, DNA sequence data are used mainly by DNA sequencers and a few theoretical biologists. DNA sequencers need to search all previously published data fast and exhaustively. DNA sequences are also translated into protein sequences, which can yield clues to the protein's function ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 65
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 757-758 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The methods for DNA sequence determination that have held sway for the last decade are starting to be challenged by a new approach that may be far better suited to large-scale sequencing projects. Variously dubbed sequencing by hybridization, hybridization sequencing, and fragmentation sequencing ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 66
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 761-761 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The poster in this issue of Bio/rerhnology–WAST CHROMOSOME III-marks a milestone in large-scale genome sequencing and mapping. Yeast chromosome III is the longest piece of DNA yet sequenced (315, 357 base pairs). It is also the first entire chromosome sequence from any organism. Obtaining the ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 67
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 768-771 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In 1984 then U.S. Secretary of Health and Human Services Margaret Heckler announced that the cause of AIDS had been discovered, and that a vaccine was just around the corner. Having crossed the threshold of the 90s, Heckler's prophecy of an AIDS vaccine appears extremely optimistic. For most of ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 68
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One goal of protein design and structural biochemistry is the reduction of complex molecules to small functional units that are amenable to high resolution analysis and rapid modification. We have developed a variety of small molecules which biochemically and biologically mimic the combining sites ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 69
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Sequence–specific enzymatic cleavage of protein fusions is an important application in recombinant protein technology. We have used the Neisseria type 2 lgA protease (EC 3.4.24.13), produced and secreted by Escherichia coli host cells, for efficiently processing polypeptides at authentic or ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 70
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 809-810 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Purification. Barrskogen (Bowie, MD) introduces the DNA Mate, a cartridge purification system that automatically delivers solvents and reagents into DNA purification cartridges for the purification of trityl-on DNA (DMT-DNA). It is designed for use with available reversed phase cartridges for the ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 71
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 706-706 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: By advocating changes in the highly successful Orphan Drug Act (“Poor Little Rich Drugs?” Bio/Technology 10:464, April, 1992) , Senator Howard M. Metzenbaum would im pose unacceptable risks on the 10,000 to 20,000 Americans who suffer from the 5,000 rare diseases for ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 72
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 471-471 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] You've raised the working capital, found your field site in what estate agents call a desirable location, and built a stunning suite of labs and offices. You've recruited an eager team of young Ph.D.s and told the world about the new company through a handsome prospectus in a nice shade of green. ...
    Type of Medium: Electronic Resource