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  • Wiley-Blackwell  (123,423)
  • 2010-2014  (46)
  • 1990-1994  (66,069)
  • 1970-1974  (30,761)
  • 1965-1969  (26,547)
Collection
Years
Year
  • 1
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: QZ365WR500:174(4)
    Keywords: Skin Neoplasms / diagnosis ; Skin Neoplasms / therapy ; Lymphoma / pathology
    Pages: xi, 425 pages : illustrations.
    Edition: 4th edition.
    ISBN: 9781118492499
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    QZ365WR500:174(4) available
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  • 2
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: QZ200:13(6)
    Keywords: Neoplasms / classification
    Notes: At head of title: UICC Union for International Cancer Control.
    Pages: 390 p. : numerous ill.
    Edition: 6th. ed.
    ISBN: 9781444332421
    Signatur Availability
    QZ200:13(6) available
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  • 3
    Unknown
    Hoboken, New Jersey : Wiley-Blackwell
    Call number: QP620:148
    Keywords: MicroRNAs
    Description / Table of Contents: Chapter 1. MicroRNAs : a brief introduction / Prof. Charles H. Lawrie. Section I: MicroRNAs as physiological regulators. Chapter 2. MicroRNA regulation of stem cell fate and reprogramming / Dr Erica Vivas, Dr Gustavo Tiscornia & Prof. Juan Carlos Izpisua Belmonte -- Chapter 3. MicroRNAs as regulators of immunity / Dr. Donald Gracias & Prof. Peter D. Katsikis -- Chapter 4. Regulation of senescence by microRNAs / Dr Ioannis Grammatikakis & Dr Myriam Gorospe -- Chapter 5. The emergence of geroMIRS: A group of microRNAs implicated in aging / Dr Alejandro Ugalde, Dr Agnieszka Kwarciak, Dr Xurde Caravia, Prof. Carlos Lopez-Ot¡n & Dr Andrew Ramsay -- Chapter 6. MicroRNAs and hematopoiesis / Dr Sukhinder Sandhu & Prof. Ramiro Garzon -- Chapter 7. MicroRNAs in platelet production and activation / Dr Leonard Edelstein, Dr Srikanth Nagalla & Prof. Paul Bray -- Section II: MicroRNAs in infectious disease: host-pathogen interactions. Chapter 8. MicroRNAs as key players in host-virus interactions / Dr Aur¿lie Fender & Dr S¿bastien Pfeffer -- Chapter 9. MicroRNA expression in avian herpesviruses / Dr. Yongxiu Yao & Prof. Venugopal Nair -- Chapter 10. Function of human cytomegalovirus microRNAs and potential roles in latency / Dr Natalie Reynolds, Dr Jon Pavelin & Dr Finn Grey -- Chapter 11. Involvement of small non-coding RNA in HIV-1 infection / Dr Guihua Sun, Prof. John Rossi & Dr Daniela Castanotto -- Chapter 12. MicroRNA in malaria / Dr Panote Prapansilp & Prof. Gareth Turner --
    Abstract: "MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research"--Provided by publisher
    Pages: xviii, 702 p. : ill.
    ISBN: 9781118300398
    Signatur Availability
    QP620:148 available
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  • 4
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: QZ200:554(7)
    Keywords: Cancer / Diagnosis ; Neoplasms / diagnosis ; Neoplasms / therapy ; Cancer / Treatment
    Pages: xv, 608 p. : ill.
    Edition: 7th ed.
    ISBN: 9781118468739
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    QZ200:554(7) available
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  • 5
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: ALLG-BERUF-W15:23
    Keywords: Research / Vocational guidance
    Pages: 142 pages : ill.
    ISBN: 9780470658208
    Signatur Availability
    ALLG-BERUF-W15:23 available
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  • 6
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: WN200:63(7)
    Keywords: Diagnostic Imaging
    Description / Table of Contents: Technical considerations -- Chest -- Cardiac disorders / with the assistance of Dr. Francesca Pugliese -- Breast imaging / with the assistance of Dr. Sarah Vinnicombe -- Plain abdomen -- Gastrointestinal tract -- Hepatobiliary system, spleen and pancreas -- Urinary tract -- Female genital tract -- Peritoneal cavity and retroperitoneum -- Bones / with the assistance of Dr. Kasthoori Jayarani -- Joints / with the assistance of Dr. Kasthoori Jayarani -- Spine -- Skeletal trauma / with the assistance of Dr. Muaaze Ahmad -- Brain -- Sinuses, orbits and neck / with the assistance of Dr. Polly Richards -- Vascular and interventional radiology
    Notes: Rev. ed. of: Diagnostic imaging / Peter Armstrong, Martin L. Wastie, Andrea G. Rockall. 6th ed. 2009.
    Pages: xi, 508 p.
    Edition: 7th ed.
    ISBN: 9780470658901
    Signatur Availability
    WN200:63(7) available
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  • 7
    Unknown
    Hoboken, NJ : Wiley-Blackwell
    Call number: QZ208:146(2)
    Keywords: Cancer / Molecular aspects ; Cancer / Genetic aspects ; Cancer cells
    Pages: xii, 620 p.
    Edition: 2nd ed.
    ISBN: 9781118022870
    Signatur Availability
    QZ208:146(2) available
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  • 8
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: WN440:27(3)
    Keywords: Nuclear Medicine ; Nuclear Physics ; Nuclear Medicine / instrumentation ; Radiation ; Radiation Effects ; Radioactive Hazard Release / prevention & control
    Pages: viii, 236 pages : illustrations
    Edition: 3rd edition.
    ISBN: 9780470905500
    Signatur Availability
    WN440:27(3) on loan
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  • 9
    Call number: ALLG-BERUF-Q179:29(2)
    Keywords: Technical writing ; Research ; Science news
    Notes: Previous edition: 2009.
    Pages: xii, 223 p.
    Edition: 2nd edition.
    ISBN: 9781118570692
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    ALLG-BERUF-Q179:29(2) available
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  • 10
    Unknown
    Hoboken, N.J. : Wiley-Blackwell
    Call number: QH207:17(2) ; A991:23
    Keywords: Microscopy ; Image Processing, Computer-Assisted
    Description / Table of Contents: Fundamentals of light microscopy -- Light and color -- Illuminators, filters, and the isolation of specific wavelengths -- Lenses and geometrical optics -- Diffraction and interference in image formation -- Diffraction and spatial resolution -- Phase contrast microscopy and darkfield microscopy -- Properties of polarized light -- Polarization microscopy -- Differential interference contrast (DIC) microscopy and modulation contrast microscopy -- Fluorescence microscopy -- Fluorescence imaging of dynamic molecular processes -- Confocal laser scanning microscopy -- Two-photon excitation fluorescence microscopy -- Superresolution imaging -- Imaging living cells with the microscope -- Fundamentals of digital imaging -- Digital imaging processing
    Pages: xiii, 538 p. : ill.
    Edition: 2nd ed.
    ISBN: 9780471692140
    Signatur Availability
    QH207:17(2) available
    A991:23 departmental collection or stack – please contact the library
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  • 11
    Unknown
    Chichester : Wiley-Blackwell
    Call number: QR41:24(2)
    Keywords: Microbiology
    Description / Table of Contents: Microbiology: what, why and how? -- Biochemical principles -- Cell structure and organization -- Microbial nutrition and cultivation -- Microbial growth -- Microbial metabolism -- Procaryotic diversity -- The fungi -- The protista -- The viruses -- Microbial genetics -- Microorganisms in genetic engineering --Control of microorganisms -- Antimicrobial agents -- Microbial associations --Microorganisms in the environment -- Industrial and food microbiology
    Notes: Includes index.
    Pages: x, 511 p. : ill.
    Edition: 2nd ed.
    ISBN: 9781119978909
    Signatur Availability
    QR41:24(2) available
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  • 12
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: QY25:22
    Keywords: Diagnosis, Laboratory ; Medical laboratory technology ; Pathology, Clinical / methods ; Clinical Laboratory Techniques
    Pages: x, 424 p. : ill. (chiefly col.)
    ISBN: 9780470997741
    Signatur Availability
    QY25:22 available
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  • 13
    Unknown
    Weinheim : Wiley-Blackwell
    Call number: QR181:90
    Keywords: Immunology
    Pages: xx, 351 p.
    ISBN: 9783527324309
    Signatur Availability
    QR181:90 available
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  • 14
    Call number: QH447:208(3) ; W450:3
    Keywords: Molecular genetics ; Genes ; Genomes
    Pages: xiv, 386 p. : ill.
    Edition: 3rd ed.
    ISBN: 9780470683859
    Signatur Availability
    QH447:208(3) available
    W450:3 departmental collection or stack – please contact the library
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  • 15
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: QV38:90
    Keywords: Molecular Targeted Therapy ; Pharmacogenetics / methods ; Drug Delivery Systems ; Drug Discovery
    Description / Table of Contents: Introduction to drug targets and molecular pharmacology -- Molecular cloning of drug targets -- G protein-coupled receptors -- Ion channels -- Transporter proteins -- Cystic fibrosis : alternative approaches to the treatment of a genetic disease -- Pharmacogenomics -- Transcription factors and gene expression -- Cellular calcium -- Genetic engineering of mice -- Signalling complexes : protein-protein interactions and lipid rafts -- Recombinant proteins and immunotherapeutics
    Notes: Includes index.
    Pages: xiv, 409 p. : ill.
    ISBN: 9780470684436
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    QV38:90 available
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  • 16
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: QR181:89(4)
    Keywords: Immune System ; Immunity ; Immune System / physiology ; Immune System / anatomy & histology ; Immune System / physiopathology ; Immunity / physiology
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: ix, 141 p. : ill.
    Edition: 4th ed.
    ISBN: 9780470657294
    Signatur Availability
    QR181:89(4) available
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  • 17
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: QZ380:199
    Keywords: Central Nervous System Neoplasms
    Description / Table of Contents: Diagnosis of brain tumors : clinical and radiographic / Isabel Arrillaga-Romany, Eudocia Quant Lee, and Patrick Y. Wen -- Epidemiology and etiology / Melissa L. Bondy, Yanhong Liu, and Michael Scheurer -- General aspects of surgery / Brian Williams, Robert Louis, and Mark Shaffrey -- General approach to radiation oncology / Jennifer S. Yu and Daphne Haas-Kogan -- General aspects of chemotherapy including "biologic agents" / Jethro Hu and Santosh Kesari -- Malignant gliomas in adulthood / Michael Ivan, Matthew Tate, and Jennifer Clarke -- LGG and oligodendrogliomas in adulthood / Derek R Johnson and Kurt A. Jaeckle -- Ependymomas / Kanwal P.S. Raghav and Mark Gilbert -- Germ cell tumors and other pineal region tumors / Geneviève Legault and Jeffrey C. Allen -- Sellar tumors : pituitary adenomas and craniopharyngiomas / Robert G. Louis, Robert Dallapiazza, and John Jane Jr -- Meningiomas / Wendy Sherman and Jeffrey Raizer -- Primary central nervous system lymphomas / Jerome Graber and Antonio M.P. Omuro -- Intradural spinal cord tumors / Ben Shofty ... [et al.] -- Gliomas in childhood / Bruce H. Cohen -- Embryonal tumors / Roger J. Packer -- Infantile brain tumors / Alyssa Reddy -- Intracranial metastases / Mary Welch and Thomas J. Kaley -- Spinal cord compression / Melike Mut -- Leptomeningeal metastases / Sean Grimm and Marc Chamberlain -- Immune mediated paraneoplastic neurologic disorders : an overview / Myrna R. Rosenfeld and Josep Dalmau -- Neurotoxicity of radiation therapy and chemotherapy / Eudocia C. Quant Lee
    Pages: xii, 246 p.
    Edition: 1st ed.
    ISBN: 9780470655757
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    QZ380:199 available
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  • 18
    Call number: QZ365WS200:47(2)
    Keywords: Child ; Hematologic Diseases ; Neoplasms
    Notes: Rev. ed. of: The Children's Hospital Oakland hematology/oncology handbook / Caroline Hastings. 1st ed. c2002.
    Pages: vi, 378 p.
    Edition: 2nd ed.
    ISBN: 9780470670880
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    QZ365WS200:47(2) available
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  • 19
    Unknown
    Weinheim : Wiley-Blackwell
    Call number: QH447:209
    Keywords: Sequence Analysis, DNA ; Sequence Analysis, RNA
    Pages: xxv, 581 p. : ill.
    ISBN: 9783527328192
    Signatur Availability
    QH447:209 available
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  • 20
    Unknown
    Hoboken, N.J. : Wiley-Blackwell
    Call number: QZ208:145(3)
    Keywords: Neoplasms / genetics ; Neoplasms / psychology ; Neoplasms / nursing ; Genetic Counseling
    Pages: xiv, 480 p. : ill.
    Edition: 3rd ed.
    ISBN: 9780470081501
    Signatur Availability
    QZ208:145(3) available
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  • 21
    Unknown
    Malden, Mass. : Wiley-Blackwell
    Call number: WH100:41(6)
    Keywords: Hematologic Diseases
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: xi, 454 p. : ill.
    Edition: 6th ed.
    ISBN: 9781405198905
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    WH100:41(6) available
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  • 22
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: QZ350:395
    Keywords: Hematological oncology ; Flow Cytometry ; Hematologic Neoplasms / diagnosis ; Flow Cytometry / methods
    Pages: xiv, 311 p.
    ISBN: 9781444335880
    Signatur Availability
    QZ350:395 departmental collection or stack – please contact the library
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  • 23
    Unknown
    Hoboken, N.J. : Wiley-Blackwell
    Call number: QC454:28
    Keywords: Spectrum Analysis ; Spectrum Analysis
    Pages: 262 p. : ill.
    ISBN: 9781119993797
    Signatur Availability
    QC454:28 available
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  • 24
    Call number: QZ345:66
    Keywords: Soft Tissue Neoplasms
    Description / Table of Contents: (Publisher-supplied data) Chapter 1. Clinical aspects (Goldwasser) -- Chapter 2. Radiology (Brisse) -- Chapter 3. Sampling procedures (Domanski) -- Chapter 4. Ancillary techniques -- Chapter 5. Principal aspects in fine needle aspirates and core needle biopsies (Klijanienko and Lagace) -- Chapter 6. (Klijanienko and Lagace)
    Abstract: "Soft Tissue Tumors: A Multidisciplinary, Decisional Diagnostic Approach, presents in effect a distillation of these experiences, combined however with valuable data and perspectives contributed by senior pathologists, oncologists, and radiologists from several of the world's other leading cancer centers of excellence. A handful of other books to date have dealt with one or another key aspect of STTs from various perspectives, and each of these books tends to have a particular emphasis or bias (e.g., more anatomic and clinical pathology diagnostics, or more medical oncology treatment, or more radiology techniques)"--Provided by publisher
    Pages: xviii, 426 p. : ill.
    ISBN: 9780470505717
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    QZ345:66 available
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  • 25
    Unknown
    Weinheim : Wiley-Blackwell
    Call number: QZ202:519
    Keywords: Cancer / Environmental aspects ; Cancer / Risk factors
    Pages: xviii, 347 p. : ill. (some col.)
    ISBN: 9783527327539
    Signatur Availability
    QZ202:519 available
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  • 26
    Call number: WN185:11
    Keywords: Magnetic Resonance Imaging / methods
    Pages: xvi, 743 p. : ill.
    ISBN: 9780470043431
    Signatur Availability
    WN185:11 on loan
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  • 27
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: QH432:42(6)
    Keywords: Genetics, Medical
    Description / Table of Contents: Medical genetics in perspective -- Human genome structure and function -- Nucleic acid structure and function -- Molecular genetic analysis -- Chromosomes -- Gametogenesis -- Chromosome aberrations -- Typical mendelian inheritance -- Atypical mendelian inheritance -- Non-mendelian inheritance -- Medical genetics in populations -- Genetic assessment, genetic counselling and reproductive options -- Family history of cancer -- Family history of common adult-onset disorder -- Strong family history : typical Mendelian disease -- Strong family history : other inheritance mechanisms -- Positive screening result -- Family history of one or more congenital malformations -- Electronic databases : a user's guide
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: xi, 332 p. : ill.
    Edition: 6th ed.
    ISBN: 9781405169745
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    QH432:42(6) available
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  • 28
    Call number: QZ266:338
    Keywords: Neoplasms / genetics ; Neoplasms / therapy ; DNA Methylation ; Drug Design ; Epigenesis, Genetic ; Histones / metabolism
    Description / Table of Contents: (Publisher-supplied data) Section I: Epigenetics and Cell Cycle -- Epigenetic modulation of Cell Cycle: an overview? / by Micaela Montanari, Antonio Giordano, Marcella Cintorino and Marcella Macaluso -- Section II: Epigenetics and Cell Development, Senescence and Differentiation -- Epigenetic in skeletal muscle Development? / by Cristina Giacinti and Antonio Giordano -- Epigenetic control in cellular senescence? / by Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn -- Epigenetic modulation in cell development and differentiation? / by Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca and Francesca Pentimalli -- Section III: Epigenetics and Gene Transcription -- Epigenetic control of gene transcription? / by Christian Bronner, Mayada Achour, Thierry Chataigneau and Valerie B. Schini-Kerth -- Epigenetics, microRNAs and cancer: an update? / by Giuseppe Russo1, Andrew Puca, Francesco Masulli, Stefano Rovetta, Letizia Cito, Debora Muresu, Flavio Rizzolio and Antonio Giordano -- Section IV: Epigenetics and Cancer -- Epigenetics and Cancer? by Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon, Alexander Mazo, and Richard G. Pestell --
    Abstract: "Biomolecular Therapeutics for Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences"--Provided by publisher
    Pages: xv, 390 p. : ill.
    ISBN: 9780471710967
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    QZ266:338 available
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  • 29
    Unknown
    Hoboken, N.J. : Wiley-Blackwell
    Call number: ALLG-BERUF-Q179:41
    Keywords: Biology / Authorship ; Authorship / Marketing ; Technical writing / Vocational guidance
    Description / Table of Contents: Machine generated contents note: Preface. -- Section I. Preliminary Considerations. -- Chapter 1 The Importance of and Need for Publishing. -- Chapter 2 Steps in Manuscript Preparation and Getting Started. -- Chapter 3 Ethical Issues in Publishing. -- Chapter 4 Choosing Your Coauthors. -- Chapter 5 Choosing Your Journal. -- Chapter 6 Principles and Characteristics of Good Scientific Writing. -- Section II. Development of the Manuscript. -- Chapter 7 Developing the Take-home Messages and a Provisional Title. -- Chapter 8 Organizing and Outlining Your Manuscript. -- Chapter 9 Results I: Overview. -- Chapter 10 Results II: Presentation. -- Chapter 11 Results III: Options for Presenting Results. -- Chapter 12 Results IV: Guidelines for Preparing Written Text of Results. -- Chapter 13 Revising and Editing. -- Chapter 14 References. -- Chapter 15 Materials and Methods. -- Chapter 16 Introduction: Rationale, Review of Literature, and Statements of Objectives. -- Chapter 17 Discussion. -- Chapter 18 Abstract. -- Chapter 19 Title, By-line, Keywords, and Authorship Footnote Items. -- Chapter 20 Polishing Your Manuscript with Good Word Usage: Choice of Words, Misspelled Words, and Misused Words. -- Section III. Review, Submission, and Postsubmission Issues. -- Chapter 21 In-house Manuscript Review Process. -- Chapter 22 Cover Letter and Submission Form Preparation. -- Chapter 23 Final Checklist and Initial Manuscript Submission. -- Chapter 24 The Peer-Review Process of Your Initial Submission. -- Chapter 25 Response-letter Preparation and Manuscript Resubmission. -- Chapter 26 Proofs, Proofreading, and the Final Steps in the Publication Process. -- Appendices. -- Index/Indices
    Abstract: "The goal of this book is to make it easier for scientists, especially those new to scientific writing, to write about their results and to get their manuscripts accepted in peer-reviewed journals. The book covers each step throughout the submission process, from organizing and outlining the manuscript, presenting statistical data and results, to what happens during the in-house manuscript review process and what to do if an article is initially rejected. In addition to providing practical exercises on these topics, the book focuses on helping writers distil their research into concise take-home messages for readers, in order to convey information as clearly as possible to the target audience"--Provided by publisher
    Pages: ix, 356 p. : ill.
    ISBN: 9781118017166
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    ALLG-BERUF-Q179:41 available
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  • 30
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: WN185:10(4)
    Keywords: Magnetic Resonance Imaging
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: vii,442 p. : ill.
    Edition: 4th ed.
    ISBN: 9781444337433
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    WN185:10(4) available
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  • 31
    Unknown
    Hoboken, N.J. : Wiley-Blackwell
    Call number: QZ202.6:33
    Keywords: Viral carcinogenesis ; Oncogenic Viruses ; Oncogenic Viruses ; Neoplasms / etiology ; Tumor Virus Infections
    Description / Table of Contents: Human papillomavirus-associated cancers / Rachel A. Katzenellenbogin and Denise A. Galloway -- Molecular events associated with human papillomavirus-induced human cancer / Amy Baldwin and Karl Munger -- The role of the human papillomavirus E6 oncoprotein in malignant progression / Miranda Thomas, David Pim, and Lawrence Banks -- JC virus association with brain tumors : the role of T antigen and insulin like growth factor 1 in DNA repair fidelity / Krzysztof Reiss, Kamel Khalili, and Louis Del Valle -- Involvement of the polyomavirus, JC virus in colorectal cancer / C. Richard Boland, Luigi Ricciardiello, and Ajay Goel -- Possible association of BK virus with prostate cancer / Michael J. Imperiale and Dweepanita Das -- Oncogenic transformation by polyomavirus large T antigen / Abhilasha V. Rathi and James M. Pipas -- Simian virus 40, human infections, and cancer : emerging concepts and causality considerations / Janet S. Butel -- Simian virus 40 and mesothelioma / Natalya Baranova and Michele Carbone -- Molecular immunology of hepatitus B-associated viral cancer / Timothy M. Block and Anand S. Mehta -- Hepititis B vaccine and hepatocellular carcinoma / Mei-Hwei Chang and Ding-Shinn Chen -- Pathogenesis of acute and chronic hepatitus C virus infection / Mark A. Feitelson ... [et al.] -- Molecular mechanisms of hepatitis C virus-induced cellular transformation / Donna Sir and Jing-hsiung James Ou -- Clinical aspects of HTLV-1 associated cancer / Masao Matsuoka -- Oncogenic potential of the HTLV-1 tax protein / Susan J. Marriott -- HIV-associated malignancy : basic and clinical aspects / Melissa Agsalda and Bruce Shiramizu -- HIV-related lymphoma / Giulia De Falco ... [et al.] -- Biology and epidemiology of HHV-8 / Veenu Minhas and Charles Wood -- The role of KSHV in pathogenesis of Kaposi's sarcoma / Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger -- Molecular pathobiology of EBV infection / Joseph Pagano -- Epstein-Barr virus as a pathogen / Wasim A
    Pages: xv, 475 p., [16] p. of plates : ill. (some col.)
    ISBN: 9780470379912
    Signatur Availability
    QZ202.6:33 available
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  • 32
    Call number: QZ266:328
    Keywords: Neoplasms / drug therapy ; Angiogenesis Inhibitors / therapeutic use ; Neoplasms / blood supply ; Neovascularization, Pathologic / drug therapy
    Pages: xxii, 329 p. : ill.
    ISBN: 9783527320912
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    QZ266:328 available
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  • 33
    Unknown
    Weinheim : Wiley-Blackwell
    Call number: W26.5:99
    Keywords: Biostatistics ; Oligonucleotide Array Sequence Analysis ; Genetic Diseases, Inborn / epidemiology
    Pages: xxviii, 383 p. : ill. (some col.)
    ISBN: 9783527325856
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    W26.5:99 available
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  • 34
    Unknown
    Chichester : Wiley-Blackwell
    Call number: QZ365WI735:78(3)
    Keywords: Liver / Cancer ; Liver Neoplasms / therapy
    Pages: xv, 558 p. : ill.
    Edition: 3rd ed.
    ISBN: 9781405179768
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    QZ365WI735:78(3) available
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  • 35
    Call number: QZ200:9(7) ; C020:124 ; C070:13 ; M100:315
    Keywords: Neoplasms / classification
    Description / Table of Contents: Head and neck tumours -- Digestive system tumours -- Tumours of bone and soft tissues -- Breast tumours -- Gynaecological tumours -- Urological tumours -- Ophthalmic tumours -- Hodgkin lymphoma -- Non-Hodgkin lymphomas
    Notes: At head of title: UICC International Union Against Cancer.
    Edition: 7th ed. 2009
    ISBN: 9781444332414
    Signatur Availability
    QZ200:9(7) available
    C020:124 departmental collection or stack – please contact the library
    C070:13 departmental collection or stack – please contact the library
    M100:315 departmental collection or stack – please contact the library
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  • 36
    Unknown
    Chichester, West Sussex : Wiley-Blackwell
    Call number: QP514:67
    Keywords: Biochemical Phenomena
    Description / Table of Contents: Nutrition -- Metabolism and energy -- Regulating body weight -- Digestion and absorption -- Synthesis, mobilisation & transport of lipids & lipoproteins -- The liver -- Alcohol metabolism & cirrhosis -- Protein structures -- Enzymes and diagnosis -- The kidney -- Haemostasis -- Bone metabolism and calcium homeostasis -- Intracellular signalling -- Inflammation -- The immune response -- Mitochondrial dysfunction -- Nerve & muscle systems -- The cytoskeleton -- Genes & medicine -- Antimicrobial drug resistance
    Notes: Includes index.
    Pages: [xv], 308 p. : ill.
    ISBN: 9780470743287
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    QP514:67 available
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  • 37
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: WH100:39(3)
    Keywords: Blood / Diseases ; Hematologic Diseases ; Molecular Biology
    Pages: xv, 410 p., [22] p. of plates : ill. (some col.)
    Edition: 3rd ed.
    ISBN: 9781405182317
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    WH100:39(3) available
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  • 38
    Call number: QH585:108(6) ; L301:1
    Keywords: Tissue Culture ; Cell Culture ; Cells, Cultured ; Culture Techniques / methods
    Pages: xxxi, 732 p., [28] p. of plates : ill. (some col.)
    Edition: 6th ed.
    ISBN: 9780470528129
    Signatur Availability
    QH585:108(6) available
    L301:1 departmental collection or stack – please contact the library
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  • 39
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: QZ200:522
    Keywords: Neoplasms
    Description / Table of Contents: The basics of cancer -- Cells : the fundamental unit of life -- The human genome and protein function -- Cell cycle, oncogenes, and tumor suppressor genes -- Tumor formation, growth, and metastasis -- Cancer screening, detection, and diagnostic procedures and tests -- Cancer treatment modalities -- Breast cancer -- Ovarian cancer -- Cervical cancer -- Prostate cancer -- Testicular cancer -- Skin cancer -- Lung cancer -- Colorectal cancer -- Leukemia and lymphoma
    Pages: x, 405 p. : ill., ports.
    ISBN: 9781405156066
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  • 40
    Call number: QZ365WS200:43
    Keywords: Tumors in children ; Child ; Pediatric hematology ; Neoplasms ; Hematologic Diseases
    Description / Table of Contents: Low- and high-grade glioma / Ian F. Pollack -- Ependymoma / Thomas E. Merchant & Richard J. Gilbertson -- Embryonal tumors / Amar Gajjar & Steven C. Clifford -- Pediatric spinal cord tumors / Annie Huang, Ute Bartels & Eric Bouffet -- Pediatric craniopharyngioma, mixed glioneuronal tumors, and atypical teratoid/rhabdoid tumor / Adrienne Weeks & Michael D. Taylor -- Acute lymphoblastic leukemia / Robert Wynn -- Acute myeloid leukemia and myeloproliferative disorders / David K.H. Webb -- Non-Hodgkins lymphoma / Angelo Rosolen and Lara Mussolin -- Hodgkin's lymphoma / Wolfgang Dörffel and Dieter Körholz -- Histiocytic disorders / Sheila Weitzman and R. Maarten Egeler -- Neuroblastoma / Sucheta J Vaidya & Andrew D J Pearson -- Renal tumors / Norbert Graf and Eddy Estlin -- Soft tissue sarcoma / Gianni Bisogno & John Anderson -- Bone tumors / Richard Gorlick, Martha Perisoglou & Jeremy Whelan -- Hepatic tumors / Penelope Brock, Jack Plaschkes & Derek Roebuck -- Germ cell tumors / James Nicholson & Roger Palmer -- Retinoblastoma / Eddy Estlin, François Doz & Michael Dyer -- Rare tumors / Bernadette Brennan & Charles Stille -- Supportive care : physical consequences of cancer and its therapies / Bob Phillips & Rod Skinner -- Psychosocial needs of children with cancer and their families / Ged Lalor & Louise Talbot -- Late effects in relation to childhood cancer / Louise Talbot & Helen Spoudeas -- Palliative care / Lynda Brook -- Clinical trials involving children with cancer : organizational and ethical issues / Sue Ablett and Eddy Estlin
    Pages: viii, 433 p. : ill.
    ISBN: 9781405153508
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    QZ365WS200:43 available
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  • 41
    Call number: QZ365WP145:134(2)
    Keywords: Generative organs, Female / Surgery ; Evidence-Based Medicine ; Clinical medicine / Decision making ; Genital Neoplasms, Female / surgery ; Critical Care / methods ; Evidence-Based Medicine ; Gynecology / methods ; Perioperative Care / methods
    Description / Table of Contents: Evidence based medicine and decision support / Steven A. Vasilev -- Vascular access and other invasive procedures / Paul Koonings and Scott Lentz -- Fluids, electrolytes, and nutrition / Howard Silberman -- Preoperative evaluation / Devansu Tewari -- Postoperative surveillance and perioperative prophylaxis / Harriet Smith and Lejla Delic -- Perioperative infections : prevention and therapeutic options / Amy Stenson and Steven Vasilev -- Intraoperative and perioperative considerations in laparoscopy / Steven A. Vasilev and Scott E. Lentz -- Cervical carcinoma / Fernando Valea -- Endometrial carcinoma / Wendell Naumann -- Pelvic masses and ovarian carcinoma / Margarett Ellison -- Molar gestation / Allison E. Axtell and Steven A. Vasilev -- Perioperative issues in the management of vulvar carcinoma / Maliaka Amneus and Kathryn F. McGonigle -- Perioperative psychosocial considerations / Judith McKay -- Pain management in gynecologic oncology / Laszlo Galffy and Clayton Varga -- Fertility preservation in gynecologic oncology / Nicole Fleming -- Herbs / Scott Lentz and Alexander Vasilev -- End-of-life decision making / Scott E. Lentz
    Notes: Rev. ed. of: Perioperative and supportive care in gynecologic oncology : evidence-based management / edited by Steven A. Vasilev. c2000.
    Pages: xii, 557 p. : ill.
    Edition: 2nd ed.
    ISBN: 9780470083406
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  • 42
    Unknown
    Oxford : Wiley-Blackwell
    Call number: ALLG-BERUF-Q179:34
    Keywords: Communication in science ; Life sciences
    Pages: ix, 169 p. : ill.
    ISBN: 0470863935
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  • 43
    Unknown
    Chichester, West Sussex, UK : Wiley-Blackwell
    Call number: WB102:2(4)
    Keywords: Medical literature / Evaluation ; Medicine / Research ; Evidence-Based Medicine ; Evidence-based practice ; Journalism, Medical ; Research
    Description / Table of Contents: Why read papers at all? -- Searching the literature -- Getting your bearings : what is this paper about? -- Assessing methodological quality -- Statistics for the non-statistician -- Papers that report trials of drug treatments and other simple interventions -- Papers that report trials of complex interventions -- Papers that report diagnostic or screening tests -- Papers that summarise other papers (systematic reviews and meta-analyses) -- Papers that tell you what to do (guidelines) -- Papers that tell you what things cost (economic analyses) -- Papers that go beyond numbers (qualitative research) -- Papers that report questionnaire research -- Papers that report quality improvement case studies -- Getting evidence into practice
    Pages: xvii, 238 p. : ill.
    Edition: 4th ed.
    ISBN: 9781444334364
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    WB102:2(4) available
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  • 44
    Unknown
    Chichester : Wiley-Blackwell
    Call number: WH190:13
    Keywords: Hemoglobinopathy / Diagnosis ; Hemoglobin polymorphisms / Identification ; Hemoglobinopathies / diagnosis ; Hemoglobins / genetics
    Description / Table of Contents: Globin genes and haemoglobin -- Diagnostic procedures and principles of commonly used tests -- Common haemoglobins of major clinical or diagnostic importance -- The thalassaemias and related conditions
    Pages: vi, 254 p. : ill.
    ISBN: 9781405167154
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    WH190:13 available
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  • 45
    Unknown
    Oxford : Wiley-Blackwell
    Call number: QH442:210(6)
    Keywords: Molecular cloning ; Nucleotide sequence ; DNA / analysis
    Pages: xvi, 320 p. : col. ill., col. maps
    Edition: 6th ed.
    ISBN: 9781405181730
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  • 46
    Unknown
    Hoboken, N.J. : Wiley-Blackwell
    Call number: QZ208:143(3)
    Keywords: Genetic disorders ; Genetic Diseases, Inborn / diagnosis ; Abnormalities, Multiple / diagnosis ; Abnormalities, Multiple / therapy ; Genetic Diseases, Inborn / therapy
    Abstract: "It is imperative for primary care providers and genetic practitioners to have access to appropriate management guidelines for the diagnosis, genetic counseling and management of individuals of all ages affected by relatively common genetic syndromes. This revision of the critically acclaimed bestseller offers original insights into the medical management of 60 syndromes commonly seen by physicians. This fully revised and expanded Third Edition provides family physicians, internists, specialty physicians, medical geneticists, genetic counselors, and families of patients with a more precise reference for study of physical manuifestations of certain syndromes"--Provided by publisher
    Pages: xxii, 962 p. : ill.
    Edition: 3rd ed.
    ISBN: 9780470191415
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  • 47
    ISSN: 0886-1544
    Keywords: cleavage furrows ; cytokinesis ; actin ; phalloidin ; myosin ; filamin ; talin ; attachment plaques ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: PtK2 cells of exceptionally large size were microinjected with fluorescently labeled probes for actin, myosin, filamin, and talin in order to follow the assembly of the contractile proteins into the cleavage furrows. Whereas in cells of normal size, there is usually a diffuse pattern of localization of proteins in the cleavage furrow, in these large, flat cells the labeled proteins localized in fibers in the cleavage furrow. Often, the fibers were striated in a pattern comparable to that measured in the stress fibers of the same cell type. The presence of talin in discrete plaques along fibers in the cleavage furrows of the large cells suggests a further similarity between cleavage furrow and stress fiber structure. The presence of filamin in the cleavage furrows also suggests the possibility of an overlapping mechanism in addition to that of a talin mediated mechanism for the attachment of actin filaments to the cell surfaces in the cleavage furrow. A model is presented that emphasizes the interrelationships between stress fibers, myofibrils, and cleavage furrows. © 1994 Wiley-Liss, Inc.
    Additional Material: 11 Ill.
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  • 48
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 27 (1994), S. 161-168 
    ISSN: 0886-1544
    Keywords: fluorescent nucleotide analogs ; methylanthraniloyl ATP ; anthraniloyl ATP ; Chlamydomonas ; axonemal mutants ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Substrate analogs are useful for studying the structures of active sites and for distinguishing between similar enzyme activities. Fluorescent ribose-modified ATP analogs were used to investigate the functional differences between dynein ATPases. These analogs reactivate (support the movement of) sea urchin sperm axonemes, yet they do not reactivate wild-type Chalmydomonas axonemes. Surprisingly, the analogs reactivate the axonemes of mutants completely missing the outer arm dyneins. Competition experiments using ATP and these analogs provide strong evidence that the analogs bind to all dynein active sites but fail to release a subset of dyneins from rigor. We suggest that this subset of Chlamydomonas outer arm dyneins unable to use the analogs remains in rigor in the presence of the analogs and paralyzes the axoneme. © 1994 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
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  • 49
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    ISSN: 0886-1544
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 50
    ISSN: 0886-1544
    Keywords: sliding movement ; 22S dynein ; Tetrahymena cilia ; dynein-track ; singlet microtubule ; ATP ; polarity ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Chlamydomonas and Tetrahymena axonemal dyneins have previously been found to bind to porcine brain microtubules to produce a microtubule-dynein complex. At appropriate microtubule:dynein concentration, microtubules in the complex became covered to saturation by dynein arms of the same polarity and at a spacing of 24 nm [Haimo et al., 1979; Haimo and Fenton, 1988; Haimo, 1989; Porter and Johnson, 1983a].In the present study, two different types of microtubule-dynein complexes (α-and β-complexes) were prepared from Tetrahymena ciliary 22S dynein and porcine brain tubulin. The characteristics of the adenosine triphosphate (ATP)-induced extrusion of microtubules from these complexes were analyzed, as a simple and direct in vitro assay for the ATP-induced extrusion of single microtubules. The α-complex prepared by adding dynein to microtubules showed an interrupted sliding movement, which would stop and start several times following the addition of ATP. In the β-complex, prepared by adding dynein bound to DEAE-tubulin to pre-assembled microtubules, microtubules became covered with dynein molecules whose orientation and binding were uniform with respect to microtubule polarity. The microtubules in the β-complex extruded at 12 μm/second following the addition of ATP. Dark-field and electron microscopy indicated that the extruded microtubules had undergone sliding on a dynein-track that had become detached from the complexes and had been absorbed onto the surface of the glass slide. At higher light intensity under a dark-field microscope, the dynein-track was seen to be composed of rows of dynein molecules arranged densely. The orientation of dynein molecules in rows appeared to be uniform considering the images of bound dynein in the β-complex under electron microscope. The higher sliding velocity of the microtubules on these dynein-tracks compared to that seen on slides coated at random with dynein [Vale and Toyoshima, 1988, 1989], may be due to more efficient force generation by this dense arrangement of dynein molecules with the same polarity on the tracks. © 1994 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
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  • 51
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 27 (1994), S. 206-218 
    ISSN: 0886-1544
    Keywords: sperm motility ; sperm maturation ; flagella ; protein kinases ; protein kinase inhibitor ; cGMP ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Ejaculated ram sperm were demembranated with Triton X-100, separated from the detergent-soluble matrix, and reactivated [San Agustin and Witman (1993): Cell Motil. Cytoskeleton 24:264-273]. The percent motility of models prepared from freshly washed sperm was comparable to that of the washed sample before demembranation, regardless of whether cAMP was included in the reactivation medium. However, demembranated models derived from aging or metabolically inhibited sperm exhibited a lower percent reactivation and required cAMP to attain the level of motility of freshly washed sperm. Cyclic AMP was ∼100 times more effective than cGMP. The requirement for cAMP could be bypassed by addition of porcine heart cAMP-dependent protein kinase (PKA) catalytic subunit to the reactivation medium, demonstrating that cAMP was acting via PKA. The cAMP stimulation of reactivation was not affected by inclusion of the PKA inhibitor PKI(5-24) in the reactivation medium, but was decreased when the models were preincubated with PKI(5-24) prior to reactivation. The cytosol-free models retained 〉90% of the sperm PKA activity; therefore, the PKA appears to be anchored to internal sperm structures. This PKA could not be extracted by cAMP or Triton X-100 alone, but only by cAMP and Triton X-100 in combination. We conclude that cAMP-dependent protein phosphorylation is critical for sperm motility, but that the essential protein phosphate sites turn over slowly under our reactivation conditions, so that the cAMP requirement is apparent only in models prepared from sperm having a low internal ATP or cAMP content. Interestingly, reactivation was rapidly blocked by the peptide arg-lys-arg-ala-arg-lys-glu, which has been reported to be a selective inhibitor of cGMP-dependent protein kinase. © 1994 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
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  • 52
    ISSN: 0886-1544
    Keywords: microtubule-associated protein 2 ; neurons ; microtubule-associated proteins ; cytoskeleton ; dendrites ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Microtubule-associated protein 2 (MAP-2) is an abundant component of the cytoskeleton present in dendrites and cell bodies of neurons of the CNS. To examine the biological function of MAP-2, two MAP-2 antisense (AS) oligonucleotides complementary to the 5′ region of the rat MAP-2 cDNA were added to rat primary embryonic day 17-18 (E17-18) cultured cortical neurons 24 h after plating and neurite outgrowth and morphology studied. The treatment of primary cortical cultures with either of the two MAP-2 AS oligonucleotides resulted in decreased MAP-2 and reduction in the number of neuritic processes relative to the control or MAP-2 sense-treated cultures. By immunostaining and light microscopy the AS-treated neurons appeared smaller, more rounded, and less intensely stained for MAP-2 than the untreated or the MAP-2 sense-treated cultures. By electron microscopy disorganized microtubules and a reduction in the number of microtubules within neurites of the AS-treated cultures were observed. We conclude that MAP-2 continues to be required for microtubule spacing and stability within neurites once they have formed. © 1994 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
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  • 53
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 28 (1994), S. 1-24 
    ISSN: 0886-1544
    Keywords: myofibrillogenesis ; directionality ; non-muscle myosin II ; myosin ; α-actinin ; Z-bodies ; zeugmatin ; titin ; C-protein ; premyofibril ; nascent myofibril ; mature myofibril ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: When cardiac muscle cells are isolated from embryonic chicks and grow in culture they attach to the substrate as spherical cells with disrupted myofibrils, and over several days in culture, they spread and extend lamellae. Based on antibody localizations of various cytoskeletal proteins within the spreading cardiomyocyte, three types of myofibrils have been identified: 1) fully formed mature myofibrils that are centrally positioned in the cell, 2) premyofibrils that are closest to the cell periphery, and 3) nascent myofibrils located between the premyofibrils and the mature myofibrils. Muscle-specific myosin is localized in the A-bands in the mature, contractile myofibrils, and along the nascent myofibrils in a continuous pattern, but it is absent from the premyofibrils. Antibodies to non-muscle isoforms of myosin IIB react with the premyofibrils at the cell periphery and with the nascent myofibrils, revealing short bands of myosin between closely spaced bands of α-actinin. In the areas where the nascent myofibrils border on the mature myofibrils, the bands of non-muscle myosin II reach lengths matching the lengths of the mature A-bands. With the exception of a small transition zone consisting of one myofibril, or sometimes several sarcomeres, bordering the nascent myofibrils, there is no reaction of these non-muscle myosin IIB antibodies with the mature myofibrils in spreading myocytes. C-protein is found only in the mature myofibrils, and its presence there may prevent co-polymerization of non-muscle and muscle myosins. Antibodies directed against the non-muscle myosin isoforms, IIA, do not stain the cardiomyocytes. In contrast to the cardiomyocytes, the fibroblasts in these cultures stain with antibodies to both non-muscle myosin IIA and IIB. The premyofibrils near the leading edge of the lamellae show no reaction with antibodies to either titin or zeugmatin, whereas the nascent myofibrils and mature myofibrils do. The spacings of the banded α-actinin staining range from 0.3 to 1.4 μm in the pre- and nascent myofibrils and reach full spacings (1.8-2.5 μm) in the mature myofibrils. Based on these observations, we propose a premyofibril model in which non-muscle myosin IIB, titin, and zeugmatin play key roles in myofibrillogenesis. This model proposes that pre- and nascent myofibrils are composed of minisarcomeres that increase in length, presumably by the concurrent elongation of actin filaments, the loss of the non-muscle myosin II filaments, the fusion of dense bodies or Z-bodies to form wide Z-bands, and the capture and alignment of muscle myosin II filaments to form the full spacings of mature myofibrils. © 1994 Wiley-Liss, Inc.
    Additional Material: 16 Ill.
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  • 54
    ISSN: 0886-1544
    Keywords: cytoskeleton ; microtubule-associated protein (MAP) ; marine egg extracts ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Alkaline pH favors the assembly of microtubules (MTs) in marine egg extracts [Suprenant and Marsh, 1987: J. Cell Sci. 184:167-180; Suprenant, 1989: Exp. Cell Res. 184:167-180; 1991: Cell Motil. Cytoskeleton 19:207-220] and mammalian brain extracts [Tiwari and Suprenant, 1993: Anal. Biochem. 215:96-103], even though the assembly of purified microtubule protein (MTP) from both of these sources is favored at slightly acidic pH. The present investigation examines whether alkaline pH has a direct or indirect effect on MT nucleation and growth in soluble brain extracts. Cell-free extracts were prepared from bovine cerebral cortex, and a nucleated assembly assay was used to demonstrate that MT assembly in brain extracts is favored at slightly acidic pH. The increase in MT mass found at alkaline pH is due to an increase in the solubility of tubulin not an increase in the extent of assembly On average, 47.7 ± 11.3% of the total tubulin is soluble at pH 7.2, while only 30.9 ± 8.9% of the tubulin is soluble at pH 6.8. A model is proposed that indicates how microtubule proteins from both mammalian brain and marine eggs may be associated with pH-dependent factors. © 1994 Wiley-Liss, Inc.
    Additional Material: 11 Ill.
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  • 55
    ISSN: 0886-9383
    Keywords: PLS regression algorithm ; Kernel ; Many-variable data sets ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A fast PLS regression algorithm dealing with large data matrices with many variables (K) and fewer objects (N) is presented For such data matrices the classical algorithm is computer-intensive and memory-demanding. Recently, Lindgren et al. (J. Chemometrics, 7, 45-49 (1993)) developed a quick and efficient kernel algorithm for the case with many objects and few variables. The present paper is focused on the opposite case, i.e. many variables and fewer objects. A kernel algorithm is presented based on eigenvectors to the ‘kernel’ matrix XX TYYT, which is a square, non-symmetric matrix of size N × N, where N is the number of objects. Using the kernel matrix and the association matrices XXT (N × N) and YYT (N × N), it is possible to calculate all score and loading vectors and hence conduct a complete PLS regression including diagnostics such as R2. This is done without returning to the original data matrices X and Y. The algorithm is presented in equation form, with proofs of some new properties and as MATLAB code.
    Additional Material: 5 Ill.
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  • 56
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 8 (1994), S. 169-174 
    ISSN: 0886-9383
    Keywords: Kernel algorithm ; PLS ; SVD ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Lindgren et al. (J. Chemometrics, 7, 45-49 (1993)) published a so-called kernel algorithm for PLS regression of Y against X when the number of objects is very large. The algorithm is based solely on deflation of the cross-product matrices XTX, YTY and XTY. The algorithm is now described in a shorter and more transparent way and compared with a similar algorithm for the singular value decomposition of XTY.
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  • 57
    ISSN: 0886-9383
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 58