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2

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Health economic evaluations of non-pharmacological interventions for persons with dementia and their informal caregivers: a systematic review (2018)

Franziska Nickel, Janina Barth and Peter L. Kolominsky-Rabas

BioMed Central

In: BMC Geriatrics

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Publication Date: 2018-03-12

Description: This systematic review aims to review the literature on trial-based economic evaluations of non-pharmacological interventions directly targeted at persons with dementia as well as persons with mild cognitive i...

Electronic ISSN: 1471-2318

Topics: Medicine

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Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases (2018)

Nina Zila, Andrea Bileck, Besnik Muqaku, Lukas Janker, Ossia M. Eichhoff, Phil F. Cheng, Reinhard Dummer, Mitchell P. Levesque, Christopher Gerner and Verena Paulitschke

BioMed Central

In: Clinical Proteomics

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Publication Date: 2018-03-12

Description: MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but development of drug resistance within a median progression-free survival (PFS) of 9–12 months. Underst...

Print ISSN: 1542-6416

Electronic ISSN: 1559-0275

Topics: Medicine

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Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo (2018)

Xiao-Dan Mo, Li-Ping Gao, Qing-Jun Wang, Jie Yin and Yu-Hong Jing

BioMed Central

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Publication Date: 2018-03-12

Description: The fibrillation of islet amyloid polypeptide (IAPP) triggered the amyloid deposition, then enhanced the loss of the pancreatic islet mass. However, it is not clear what factor is the determinant in developmen...

Electronic ISSN: 1476-511X

Topics: Biology

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Proportion of medication error reporting and associated factors among nurses: a cross sectional study (2018)

Abebaw Jember, Mignote Hailu, Anteneh Messele, Tesfaye Demeke and Mohammed Hassen

BioMed Central

In: BMC Nursing

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Publication Date: 2018-03-14

Description: A medication error (ME) is any preventable event that may cause or lead to inappropriate medication use or patient harm. Voluntary reporting has a principal role in appreciating the extent and impact of medica...

Electronic ISSN: 1472-6955

Topics: Medicine

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Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology (2018)

Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A. L. Menke, Istvan N. Huszar, Mark Jenkinson, Benjamin C. Tendler, Chaoyue Wang, Saad Jbabdi, Martin R. Turner, Karla L. Miller and Olaf Ansorge

BioMed Central

In: BMC Neuroscience

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Publication Date: 2018-03-14

Description: Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Ma...

Electronic ISSN: 1471-2202

Topics: Medicine

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Palliative sedation in Germany: factors and treatment practices associated with different sedation rate estimates in palliative and hospice care services (2018)

Stephanie Stiel, Mareike Nurnus, Christoph Ostgathe and Carsten Klein

BioMed Central

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Publication Date: 2018-03-14

Description: Clinical practice of Palliative Sedation (PS) varies between institutions worldwide and sometimes includes problematic practices. Little available research points at different definitions and frameworks which ...

Electronic ISSN: 1472-684X

Topics: Medicine

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Smoking during pregnancy and harm reduction in birth weight: a cross-sectional study (2018)

Mariana Caricati Kataoka, Ana Paula Pinho Carvalheira, Anna Paula Ferrari, Maíra Barreto Malta, Maria Antonieta de Barros Leite Carvalhaes and Cristina Maria Garcia de Lima Parada

BioMed Central

In: BMC Pregnancy and Childbirth

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Publication Date: 2018-03-14

Description: Different studies have shown the advantages of abstinence from cigarette smoking during pregnancy to promote full fetal development. Given that pregnant women do not always abstain from smoking, this study aim...

Electronic ISSN: 1471-2393

Topics: Medicine

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9

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Factors associated with emergency services use in Taiwanese advanced cancer patients receiving palliative home care services during out-of-hours periods: a retrospective medical record study (2018)

Yee-Hsin Kao, Yao-Ting Liu, Malcolm Koo and Jui-Kun Chiang

BioMed Central

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Publication Date: 2018-03-14

Description: For patients receiving palliative home care, the need to visit the emergency department is considered to be an indicator of poor quality care. The situation can be particularly distressing when it occurs outsi...

Electronic ISSN: 1472-684X

Topics: Medicine

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Knowledge, attitudes and practices regarding depression among primary health care providers in Fako division, Cameroon (2018)

Isabelle Dibu Mulango, Julius Atashili, Bradley N. Gaynes and Tsi Njim

BioMed Central

In: BMC Psychiatry

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Publication Date: 2018-03-14

Description: Mental health and mental illness are often overlooked in the management of patients in our health services. Depression is a common mental disorder worldwide. Recognising and managing mental illnesses such as d...

Electronic ISSN: 1471-244X

Topics: Medicine

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Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project (2018)

Trinidad Dierssen-Sotos, Camilo Palazuelos-Calderón, José-Juan Jiménez-Moleón, Nuria Aragonés, Jone M. Altzibar, Gemma Castaño-Vinyals, Vicente Martín-Sanchez, Inés Gómez-Acebo, Marcela Guevara, Adonina Tardón, Beatriz Pérez-Gómez, Pilar Amiano, Victor Moreno, Antonio J. Molina, Jéssica Alonso-Molero, Conchi Moreno-Iribas…

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-14

Description: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.

Electronic ISSN: 1471-2407

Topics: Medicine

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Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study (2018)

D. Yao, L. Zhang, P. L. Wu, X. L. Gu, Y. F. Chen, L. X. Wang and X. Y. Huang

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-14

Description: The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and sum...

Electronic ISSN: 1471-2407

Topics: Medicine

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Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells (2018)

Shafaqat Ali, Alexander Hoven, Regine J. Dress, Heiner Schaal, Judith Alferink and Stefanie Scheu

BioMed Central

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Publication Date: 2018-03-14

Description: The murine discs large homolog 2 (DLG2; post synaptic density 93 (PSD-93); Chapsyn-110) is a member of the membrane-associated guanylate kinase (MAGUK) protein family involved in receptor assembly and associat...

Electronic ISSN: 1471-2164

Topics: Biology

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14

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Molecular mechanisms of an antimicrobial peptide piscidin (Lc-pis) in a parasitic protozoan, Cryptocaryon irritans (2018)

Ruanni Chen, Yong Mao, Jun Wang, Min Liu, Ying Qiao, Libing Zheng, Yongquan Su, Qiaozhen Ke and Weiqiang Zheng

BioMed Central

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Publication Date: 2018-03-14

Description: Cryptocaryon irritans is an obligate parasitic ciliate protozoan that can infect various commercially important mariculture fish species and cause high lethality and economic loss. Current methods of controlling ...

Electronic ISSN: 1471-2164

Topics: Biology

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Patients’ knowledge and attitudes to the Wise List - a drug formulary from the Stockholm Drug and Therapeutic committee (2018)

Pia Bastholm-Rahmner, Lars L. Gustafsson, Kristina Aggefors, Kristina Ateva, Susanne Elfving, Jaran Eriksen, Malena Jirlow, Maria Juhasz-Haverinen, Rickard E. Malmström, Mahan Nikpour-Ardaly, Magnus Röjvall, Martina Vallin, Eva Andersén-Karlsson and Marie-Louise Ovesjö

BioMed Central

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Publication Date: 2018-03-14

Description: Involving patients in decisions about their pharmacotherapy is crucial for a satisfactory treatment outcome. Information and opinions about medicines are available from a variety of sources. The Wise List is t...

Electronic ISSN: 1472-6963

Topics: Medicine

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16

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Epidemiologic analysis of respiratory viral infections among Singapore military servicemen in 2016 (2018)

Yuk-Fai Lau, Wee-Hong Victor Koh, Clement Kan, Poh-Choo Alethea Dua, Ai-Sim Elizabeth Lim, Chin-Wen Jasper Liaw, Qiu-Han Gao, Jeremiah Chng, Vernon J. Lee, Boon-Huan Tan and Jin-Phang Loh

BioMed Central

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Publication Date: 2018-03-14

Description: Respiratory illnesses have been identified as a significant factor leading to lost training time and morbidity among Singapore military recruits. A surveillance programme has been put in place to determine eti...

Electronic ISSN: 1471-2334

Topics: Medicine

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Attitudes towards help-seeking for sexual and gender-based violence in humanitarian settings: the case of Rwamwanja refugee settlement scheme in Uganda (2018)

George Odwe, Chi-Chi Undie and Francis Obare

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-14

Description: Sexual and gender-based violence (SGBV) remains a silent epidemic in many humanitarian settings with many survivors concealing their experiences. Attitudes towards help-seeking for SGBV is an important determi...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China (2018)

Meifang Su, Xiaoying Chen, Yue Chen, Congyun Wang, Songtao Li, Xuhua Ying, Tian Xiao, Na Wang, Qingwu Jiang and Chaowei Fu

BioMed Central

In: BMC Medical Genetics

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Publication Date: 2018-03-14

Description: There are disparities for the association between uncoupling proteins (UCP) and type 2 diabetes (T2DM). The study was to examine the associations of genetic variants of UCP2 and UCP3 with prediabetes and T2DM ...

Electronic ISSN: 1471-2350

Topics: Biology , Medicine

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19

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Risk factors for progression of radiographic knee osteoarthritis in elderly community residents in Korea (2018)

Jong Jin Yoo, Dong Hyun Kim and Hyun Ah Kim

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-14

Description: Knee osteoarthritis (OA) is the most common form of arthritis affecting the elderly. Understanding the risk factors for knee OA has been derived from cross sectional studies. There have been few longitudinal s...

Electronic ISSN: 1471-2474

Topics: Medicine

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On the shoulders of giants. The story behind the ‘Pioneers of Nephrology’ project (2018)

Giorgina B. Piccoli, Bernard G. Jaar and Hayley Henderson

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-14

Description: This editorial introduces a series of interviews with the pioneers of Nephrology. It’s a story that speaks by itself, given the thousands of people that are now alive thanks to the remarkable advances in renal...

Electronic ISSN: 1471-2369

Topics: Medicine

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Factors associated with seeking preventive dental care: an integrative model exploration of behaviors in Mexican immigrants in Midwest America (2018)

Jonathan T. Macy, Elizabeth A. S. Moser, Adam T. Hirsh, Patrick O. Monahan, George J. Eckert and Gerardo Maupomé

BioMed Central

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Publication Date: 2018-03-14

Description: Mexican immigrants in the United States suffer from poor oral health. The objective of the current study was to explore the utility of applying theory-based factors associated with seeking preventive dental ca...

Electronic ISSN: 1472-6831

Topics: Medicine

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Integrating palliative care in long-term care facilities across Europe (PACE): protocol of a cluster randomized controlled trial of the ‘PACE Steps to Success’ intervention in seven countries (2018)

Tinne Smets, Bregje B. D. Onwuteaka-Philipsen, Rose Miranda, Lara Pivodic, Marc Tanghe, Hein van Hout, Roeline H. R. W. Pasman, Mariska Oosterveld-Vlug, Ruth Piers, Nele Van Den Noortgate, Anne B. Wichmann, Yvonne Engels, Myrra Vernooij-Dassen, Jo Hockley, Katherine Froggatt, Sheila Payne…

BioMed Central

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Publication Date: 2018-03-14

Description: Several studies have highlighted the need for improvement in palliative care delivered to older people long-term care facilities. However, the available evidence on how to improve palliative care in these sett...

Electronic ISSN: 1472-684X

Topics: Medicine

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Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children (2018)

Pei Lin Zhuang, Li Xia Yu, Juan Kun Liao, Yan Zhou and Huan Cai Lin

BioMed Central

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Publication Date: 2018-03-14

Description: The VicRK two-component signalling system regulates virulence and cariogenicity in Streptococcus mutans (S. mutans). The purpose of this study was to explore the genetic polymorphisms of the vicR and vicK genes, ...

Electronic ISSN: 1472-6831

Topics: Medicine

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A case report of schizoaffective disorder with ritualistic behaviors and catatonic stupor: successful treatment by risperidone and modified electroconvulsive therapy (2018)

Yuanhan Bai, Xi Yang, Zhiqiang Zeng and Haichen Yang

BioMed Central

In: BMC Psychiatry

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Publication Date: 2018-03-14

Description: Ritualistic behaviors are common in obsessive compulsive disorder (OCD), while catatonic stupor occasionally occurs in psychotic or mood disorders. Schizoaffective disorder is a specific mental disorder involv...

Electronic ISSN: 1471-244X

Topics: Medicine

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A narrative account of implementation lessons learnt from the dissemination of an up-scaled state-wide child obesity management program in Australia: PEACH™ (Parenting, Eating and Activity for Child Health) Queensland (2018)

Debbie L. Croyden, Helen A. Vidgen, Emma Esdaile, Emely Hernandez, Anthea Magarey, Carly J. Moores and Lynne Daniels

BioMed Central

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Publication Date: 2018-03-14

Description: PEACH™QLD translated the PEACH™ Program, designed to manage overweight/obesity in primary school-aged children, from efficacious RCT and small scale community trial to a larger state-wide program. This paper d...

Electronic ISSN: 1471-2458

Topics: Medicine

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Promoting self-management, health literacy and social capital to reduce health inequalities in older adults living in urban disadvantaged areas: protocol of the randomised controlled trial AEQUALIS (2018)

Laura Coll-Planas, Sergi Blancafort, Xavier Rojano, Marta Roqué and Rosa Monteserín

BioMed Central

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Publication Date: 2018-03-14

Description: Older people living in socio-economic deprived urban areas especially suffer the effects of health inequalities but have been insufficiently targeted. Strategies promoted by local primary health care agents mi...

Electronic ISSN: 1471-2458

Topics: Medicine

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Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease (2018)

Noriho Sakamoto, Hiroshi Ishimoto, Tomoyuki Kakugawa, Minoru Satoh, Tomoko Hasegawa, Shin Tanaka, Atsuko Hara, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Hanako Koyama, Towako Morita, Seiko Nakamichi, Yasushi Obase, Yuji Ishimatsu and Hiroshi Mukae

BioMed Central

In: BMC Pulmonary Medicine

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Publication Date: 2018-03-14

Description: Interstitial lung disease (ILD) is a prognostic indicator of poor outcome in myositis. Although the pathogenesis of myositis-associated ILD is not well understood, neutrophils are thought to play a pivotal rol...

Electronic ISSN: 1471-2466

Topics: Medicine

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Identifying non-traditional stakeholders with whom to engage, when mitigating antimicrobial resistance in foodborne pathogens (Canada) (2018)

Shannon E. Majowicz, E. Jane Parmley, Carolee Carson and Katarina Pintar

BioMed Central

In: BMC Research Notes

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Publication Date: 2018-03-14

Description: Antimicrobial resistance (AMR) is a critical public health issue that involves interrelationships between people, animals, and the environment. Traditionally, interdisciplinary efforts to mitigate AMR in the f...

Electronic ISSN: 1756-0500

Topics: Biology , Medicine

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Inflammatory markers before and after farrowing in healthy sows and in sows affected with postpartum dysgalactia syndrome (2018)

Marianne Kaiser, Magdalena Jacobson, Pia Haubro Andersen, Poul Bækbo, José Joaquin Cerón, Jan Dahl, Damián Escribano and Stine Jacobsen

BioMed Central

In: BMC Veterinary Research

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Publication Date: 2018-03-14

Description: The pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs. Accurate and timely diagnosis is difficult, and PDS is often reco...

Electronic ISSN: 1746-6148

Topics: Medicine

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Raven food calls indicate sender’s age and sex (2018)

Markus Boeckle, Georgine Szipl and Thomas Bugnyar

BioMed Central

In: Frontiers in Zoology

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Publication Date: 2018-03-14

Description: Acoustic parameters of animal signals have been shown to correlate with various phenotypic characteristics of the sender. These acoustic characteristics can be learned and categorized and thus are a basis for ...

Electronic ISSN: 1742-9994

Topics: Biology

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A history of male migration in and out of the Green Sahara (2018)

Yali Xue

BioMed Central

In: Genome Biology

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Publication Date: 2018-03-14

Description: The Sahara was once fertile; a recent study identifies human Y-chromosomal lineages that flourished in this Green Sahara and their relation to present-day populations.

Print ISSN: 1465-6906

Electronic ISSN: 1465-6914

Topics: Biology

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Effects and mechanisms of apolipoprotein A-V on the regulation of lipid accumulation in cardiomyocytes (2018)

Jun Luo, Li Xu, Jiang Li and Shuiping Zhao

BioMed Central

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Publication Date: 2018-03-14

Description: Apolipoprotein (apo) A-V is a key regulator of triglyceride (TG) metabolism. We investigated effects of apoA-V on lipid metabolism in cardiomyocytes in this study.

Electronic ISSN: 1476-511X

Topics: Biology

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Out-of-hospital cardiac arrest in the home: Can area characteristics identify at-risk communities in the Republic of Ireland? (2018)

Siobhán Masterson, Conor Teljeur, John Cullinan, Andrew W. Murphy, Conor Deasy and Akke Vellinga

BioMed Central

In: International Journal of Health Geographics

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Publication Date: 2018-03-06

Description: Internationally, the majority of out-of-hospital cardiac arrests where resuscitation is attempted (OHCAs) occur in private residential locations i.e. at home. The prospect of survival for this patient group is...

Electronic ISSN: 1476-072X

Topics: Medicine

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Proteomic identification of moesin upon exposure to acrolein (2018)

Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, George D. Leikauf and An-Soo Jang

BioMed Central

In: Proteome Science

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Publication Date: 2018-03-06

Description: Acrolein (allyl Aldehyde) as one of smoke irritant exacerbates chronic airway diseases and increased in sputum of patients with asthma and chronic obstructive lung disease. But underlying mechanism remains unr...

Electronic ISSN: 1477-5956

Topics: Medicine

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Canine caliciviruses of four serotypes from military and research dogs recovered in 1963−1978 belong to two phylogenetic clades in the Vesivirus genus (2018)

Leonard N. Binn, Erica A. Norby, Ruth H. Marchwicki, Richard G. Jarman, Paul B. Keiser and Jun Hang

BioMed Central

In: Virology Journal

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Publication Date: 2018-03-06

Description: Vesiviruses (family Caliciviridae) had been shown capable of invading a variety of host species, raising concern of their zoonotic potential. Since the 1980’s, several canine caliciviruses (CaCV) isolates have be...

Electronic ISSN: 1743-422X

Topics: Medicine

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Reassessment of the capacity of the HIV-1 Env cytoplasmic domain to trigger NF-κB activation (2018)

Cyprien Beraud, Morgane Lemaire and Danielle Perez Bercoff

BioMed Central

In: Virology Journal

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Publication Date: 2018-03-06

Description: The cytoplasmic domain of lentiviral Envelopes (EnvCD) ensures Env incorporation into nascent virions and regulates Env trafficking to and from the plasma membrane. It has also been reported to promote transcr...

Electronic ISSN: 1743-422X

Topics: Medicine

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A sophisticated, differentiated Golgi in the ancestor of eukaryotes (2018)

Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks

BioMed Central

In: BMC Biology

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Publication Date: 2018-03-07

Description: The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle’s dysfunction results in human disease. Its characteristic morphology of multiple di...

Electronic ISSN: 1741-7007

Topics: Biology

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38

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Temporal and geographic variation in the systemic treatment of advanced prostate cancer (2018)

Megan E. V. Caram, Jason P. Estes, Jennifer J. Griggs, Paul Lin and Bhramar Mukherjee

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-07

Description: Several systemic treatments have been shown to increase survival for patients with metastatic castration-resistant prostate cancer. This study sought to characterize variation in use of the six “focus drugs” (...

Electronic ISSN: 1471-2407

Topics: Medicine

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TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location (2018)

Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang and Qun Wang

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-07

Description: TIPE3 (TNFAIP8L3), a transfer protein for lipid second messengers, is upregulated in human lung cancer tissues. The most popular lung cancer is non-small cell lung cancer (NSCLC) with high incidences and low s...

Electronic ISSN: 1471-2407

Topics: Medicine

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Substance use and self-harm: a cross-sectional study of the prevalence, correlates and patterns of medical service utilisation among patients admitted to a South African hospital (2018)

Elsie Breet, Jason Bantjes and Ian Lewis

BioMed Central

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Publication Date: 2018-03-07

Description: Substance use is a potentially modifiable risk factor for suicidal behaviour. Little is known about the epidemiology of substance use among self-harm patients in South Africa. This study set out to collect epi...

Electronic ISSN: 1472-6963

Topics: Medicine

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Investigation of household contacts of pulmonary tuberculosis patients increases case detection in Mwanza City, Tanzania (2018)

Medard Beyanga, Benson R. Kidenya, Lisa Gerwing-Adima, Eleanor Ochodo, Stephen E. Mshana and Christa Kasang

BioMed Central

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Publication Date: 2018-03-07

Description: Tuberculosis (TB) contact tracing is a key strategy for containing TB and provides addition to the passive case finding approach. However, this practice has not been implemented in Tanzania, where there is una...

Electronic ISSN: 1471-2334

Topics: Medicine

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42

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Whole exome sequencing in three families segregating a pediatric case of sarcoidosis (2018)

Alain Calender, Pierre Antoine Rollat Farnier, Adrien Buisson, Stéphane Pinson, Abderrazzaq Bentaher, Serge Lebecque, Harriet Corvol, Rola Abou Taam, Véronique Houdouin, Claire Bardel, Pascal Roy, Gilles Devouassoux, Vincent Cottin, Pascal Seve, Jean-François Bernaudin, Clarice X. Lim…

BioMed Central

In: BMC Medical Genomics

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Publication Date: 2018-03-07

Description: Sarcoidosis (OMIM 181000) is a multi-systemic granulomatous disorder of unknown origin. Despite multiple genome-wide association (GWAS) studies, no major pathogenic pathways have been identified to date. To fi...

Electronic ISSN: 1755-8794

Topics: Medicine

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43

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An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature (2018)

Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth and Beatrix Sármán

BioMed Central

In: BMC Medical Genetics

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Publication Date: 2018-03-07

Description: Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR). Clinically it is characterized by symptoms developed due to local, ...

Electronic ISSN: 1471-2350

Topics: Biology , Medicine

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44

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Fundus changes in type III membranoproliferative glomerulonephritis: a case report (2018)

Masato Takei, Akira Obana, Takenori Inomata, Takao Tanaka, Tina Shiang, Yuan Bae, Tamiko Takemura and Akira Murakami

BioMed Central

In: BMC Ophthalmology

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Publication Date: 2018-03-07

Description: Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation and is classified into types I, II and III based on structural changes in the glomerular capillary walls. The dr...

Electronic ISSN: 1471-2415

Topics: Medicine

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45

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An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration (2018)

Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn and Anne J. Ridley

BioMed Central

In: BMC Biology

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Publication Date: 2018-03-07

Description: Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects...

Electronic ISSN: 1741-7007

Topics: Biology

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46

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Quadruplex DNA in long terminal repeats in maize LTR retrotransposons inhibits the expression of a reporter gene in yeast (2018)

Viktor Tokan, Janka Puterova, Matej Lexa and Eduard Kejnovsky

BioMed Central

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Publication Date: 2018-03-07

Description: Many studies have shown that guanine-rich DNA sequences form quadruplex structures (G4) in vitro but there is scarce evidence of guanine quadruplexes in vivo. The majority of potential quadruplex-forming seque...

Electronic ISSN: 1471-2164

Topics: Biology

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47

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JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process (2018)

Ling Wang, Zongliang Jiang, Delun Huang, Jingyue Duan, Chang Huang, Shannon Sullivan, Kaneha Vali, Yexuan Yin, Ming Zhang, Jill Wegrzyn, Xiuchun ( Cindy) Tian and Young Tang

BioMed Central

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Publication Date: 2018-03-07

Description: The generation of induced pluripotent stem cells (iPSCs) has underdefined mechanisms. In addition, leukemia inhibitory factor (LIF) activated Janus kinase/signal transducer and activator of transcription 3 (JA...

Electronic ISSN: 1471-2164

Topics: Biology

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48

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Factors affecting time to sputum culture conversion and treatment outcome of patients with multidrug-resistant tuberculosis in China (2018)

Qiao Liu, Peng Lu, Leonardo Martinez, Haitao Yang, Wei Lu, Xiaoyan Ding and Limei Zhu

BioMed Central

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Publication Date: 2018-03-07

Description: Few prospective cohort studies, none in China, have investigated the relationship between treatment outcomes of multidrug-resistant tuberculosis (MDR-TB) patients and sputum culture conversion. Factors affecti...

Electronic ISSN: 1471-2334

Topics: Medicine

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49

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High seroprevalence of syphilis infection among pregnant women in Yiregalem hospital southern Ethiopia (2018)

Anteneh Amsalu, Getachew Ferede and Demissie Assegu

BioMed Central

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Publication Date: 2018-03-07

Description: Despite availability of effective treatment and the implementation of focused antenatal care (ANC), still the prevalence of syphilis persists in Ethiopia. Yet, data is not found in southern Ethiopia. Therefore...

Electronic ISSN: 1471-2334

Topics: Medicine

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50

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Prevalence, risk factors and behavioural and emotional comorbidity of acute seizures in young Kenyan children: a population-based study (2018)

Symon M. Kariuki, Amina Abubakar, Martha Kombe, Michael Kazungu, Rachael Odhiambo, Alan Stein and Charles R. J. C. Newton

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-07

Description: Acute symptomatic seizures and febrile seizures are common in children admitted to hospitals in Africa and may be markers of brain dysfunction. They may be associated with behavioural and emotional problems, b...

Electronic ISSN: 1741-7015

Topics: Medicine

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51

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Oral health service utilization patterns among preschool children in Beijing, China (2018)

Mengru Xu, Chao Yuan, Xiangyu Sun, Menglin Cheng, Yanyi Xie and Yan Si

BioMed Central

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Publication Date: 2018-03-07

Description: The utilization of oral health services in children remains at a relatively low level in China. However, little is known about the utilization patterns and related factors. The objective of this study was to e...

Electronic ISSN: 1472-6831

Topics: Medicine

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52

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Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY) (2018)

Xiuzhen Li, Tzer Hwu Ting, Huiying Sheng, Cui Li Liang, Yongxian Shao, Minyan Jiang, Aijing Xu, Yunting Lin and Li Liu

BioMed Central

In: BMC Pediatrics

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Publication Date: 2018-03-07

Description: There is scarcity of information on the clinical features and genetics of glucokinase-maturity-onset diabetes of the young (GCK-MODY) in China. The aim of the study was to investigate the clinical and molecula...

Electronic ISSN: 1471-2431

Topics: Medicine

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Spatial variation in the use of reproductive health services over time: a decomposition analysis (2018)

Gordon Abekah-Nkrumah

BioMed Central

In: BMC Pregnancy and Childbirth

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Publication Date: 2018-03-07

Description: The paper argues that several Sub-Saharan African countries have recorded marked improvements in the use of reproductive health services. However, the literature has hardly highlighted such progress and the fa...

Electronic ISSN: 1471-2393

Topics: Medicine

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A program to respond to otitis media in remote Australian Aboriginal communities: a qualitative investigation of parent perspectives (2018)

Caroline Jones, Mridula Sharma, Samantha Harkus, Catherine McMahon, Mele Taumoepeau, Katherine Demuth, Karen Mattock, Lee Rosas, Raelene Wing, Sulabha Pawar and Anne Hampshire

BioMed Central

In: BMC Pediatrics

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Publication Date: 2018-03-07

Description: Indigenous infants and children in Australia, especially in remote communities, experience early and chronic otitis media (OM) which is difficult to treat and has lifelong impacts in health and education. The ...

Electronic ISSN: 1471-2431

Topics: Medicine

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Physical activity, obesity and sedentary behaviour and the risks of colon and rectal cancers in the 45 and up study (2018)

Carlos Nunez, Visalini Nair-Shalliker, Sam Egger, Freddy Sitas and Adrian Bauman

BioMed Central

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Publication Date: 2018-03-07

Description: Obesity and physical activity (PA) are predictors of colon (CC) and rectal (RC) cancers. Prolonged sitting is also emerging as a potential predictor for these cancers. Little knowledge exists about the interac...

Electronic ISSN: 1471-2458

Topics: Medicine

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Predictive factors for major postoperative complications related to gastric conduit reconstruction in thoracoscopic esophagectomy for esophageal cancer: a case control study (2018)

Shinichiro Kobayashi, Kengo Kanetaka, Yasuhiro Nagata, Masahiko Nakayama, Ryo Matsumoto, Mitsuhisa Takatsuki and Susumu Eguchi

BioMed Central

In: BMC Surgery

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Publication Date: 2018-03-07

Description: Regardless of developments in thoracoscopic esophagectomy (TE), postoperative complications relative to gastric conduit reconstruction are common after esophagectomy. The aim of the present study was to evalua...

Electronic ISSN: 1471-2482

Topics: Medicine

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Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization (2018)

Melanie Christine Föll, Matthias Fahrner, Victor Oginga Oria, Markus Kühs, Martin Lothar Biniossek, Martin Werner, Peter Bronsert and Oliver Schilling

BioMed Central

In: Clinical Proteomics

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Publication Date: 2018-03-07

Description: Proteomic analyses of clinical specimens often rely on human tissues preserved through formalin-fixation and paraffin embedding (FFPE). Minimal sample consumption is the key to preserve the integrity of pathol...

Print ISSN: 1542-6416

Electronic ISSN: 1559-0275

Topics: Medicine

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Correction to: Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain (2018)

S. Perez, A. Iñarrea, R. Pérez-Tanoira, M. Gil, E. López-Díez, O. Valenzuela, M. Porto, L. Alberte-Lista, M. A. Peteiro-Cancelo, A. Treinta, R. Carballo, M. C. Reboredo, M. E. Alvarez-Argüelles and M. J. Purriños

BioMed Central

In: Virology Journal

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Publication Date: 2018-03-07

Description: After publication of the article [1], it was brought to our attention that the author E. López-Díez is missing their second affiliation. The author would also like to indicate an affiliation to “Universidade d...

Electronic ISSN: 1743-422X

Topics: Medicine

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Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease (2018)

Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi and Michael R. Hayden

BioMed Central

In: Acta Neuropathologica Communications

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Publication Date: 2018-03-09

Description: Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests a...

Electronic ISSN: 2051-5960

Topics: Medicine

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Prospective study of bilateral mix-and-match implantation of diffractive multifocal intraocular lenses in Koreans (2018)

Chan Min Yang, Dong Hui Lim, Sungsoon Hwang, Joo Hyun and Tae-Young Chung

BioMed Central

In: BMC Ophthalmology

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Publication Date: 2018-03-09

Description: To evaluate monocular and binocular visual outcomes for near, intermediate, and far distance in patients implanted with diffractive multifocal intraocular lenses (IOLs) with different add power contralaterally.

Electronic ISSN: 1471-2415

Topics: Medicine

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Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis (2018)

Zhan-shan Zhang

BioMed Central

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Publication Date: 2018-03-09

Description: Studies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore ...

Electronic ISSN: 1472-6831

Topics: Medicine

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Temporomandibular disorders and psychosocial status in osteogenesis imperfecta - a cross-sectional study (2018)

K. H. Bendixen, H. Gjørup, L. Baad-Hansen, J. Dahl Hald, T. Harsløf, M. H. Schmidt, B. L. Langdahl and D. Haubek

BioMed Central

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Publication Date: 2018-03-09

Description: Osteogenesis Imperfecta (OI) is characterized by a number of deviations in the orofacial region. The aims of the present study were to investigate the occurrence of temporomandibular disorders, to evaluate the...

Electronic ISSN: 1472-6831

Topics: Medicine

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Palliative care in the emergency department: an educational investigation and intervention (2018)

Jessica M. Goldonowicz, Michael S. Runyon and Mark J. Bullard

BioMed Central

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Publication Date: 2018-03-09

Description: To investigate the value of a novel simulation-based palliative care educational intervention within an emergency medicine (EM) residency curriculum.

Electronic ISSN: 1472-684X

Topics: Medicine

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Palliative care in the home: a scoping review of study quality, primary outcomes, and thematic component analysis (2018)

Mark Hofmeister, Ally Memedovich, Laura E. Dowsett, Laura Sevick, Tamara McCarron, Eldon Spackman, Tania Stafinski, Devidas Menon, Tom Noseworthy and Fiona Clement

BioMed Central

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Publication Date: 2018-03-09

Description: The aim of palliative care is to improve the quality of life of patients and families through the prevention and relief of suffering. Frequently, patients may choose to receive palliative care in the home. The...

Electronic ISSN: 1472-684X

Topics: Medicine

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Efficacy of serum procalcitonin to predict spontaneous preterm birth in women with threatened preterm labour: a prospective observational study (2018)

Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital and Jérôme Dimet

BioMed Central

In: BMC Pregnancy and Childbirth

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Publication Date: 2018-03-09

Description: A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory ...

Electronic ISSN: 1471-2393

Topics: Medicine

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66

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Systems biology as an emerging paradigm in transfusion medicine (2018)

James T. Yurkovich, Aarash Bordbar, Ólafur E. Sigurjónsson and Bernhard O. Palsson

BioMed Central

In: BMC Systems Biology

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Publication Date: 2018-03-09

Description: Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “o...

Electronic ISSN: 1752-0509

Topics: Biology

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The English National Cohort Study of Flooding and Health: the change in the prevalence of psychological morbidity at year two (2018)

Daiga Jermacane, Thomas David Waite, Charles R. Beck, Angie Bone, Richard Amlôt, Mark Reacher, Sari Kovats, Ben Armstrong, Giovanni Leonardi, G. James Rubin and Isabel Oliver

BioMed Central

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Publication Date: 2018-03-09

Description: The longer term impact of flooding on health is poorly understood. In 2015, following widespread flooding in the UK during winter 2013/14, Public Health England launched the English National Study of Flooding ...

Electronic ISSN: 1471-2458

Topics: Medicine

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Correction to: Mixed-method tutoring support improves learning outcomes of veterinary students in basic subjects (2018)

M. J. García-Iglesias, C. Pérez-Martínez, C. B. Gutiérrez-Martín, R. Díez-Laiz and A. M. Sahagún-Prieto

BioMed Central

In: BMC Veterinary Research

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Publication Date: 2018-03-09

Description: The original article [1] contains an error whereby Fig. 2a and b are mistakenly swapped with each other, and thus do not correspond to their correct respective sub-headings in the caption.

Electronic ISSN: 1746-6148

Topics: Medicine

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The origins of breast cancer associated with mammographic density: a testable biological hypothesis (2018)

Norman Boyd, Hal Berman, Jie Zhu, Lisa J. Martin, Martin J. Yaffe, Sofia Chavez, Greg Stanisz, Greg Hislop, Anna M. Chiarelli, Salomon Minkin and Andrew D. Paterson

BioMed Central

In: Breast Cancer Research

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Publication Date: 2018-03-09

Description: Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density (PMD), and to reconcile the apparent parad...

Print ISSN: 1465-5411

Electronic ISSN: 1465-542X

Topics: Medicine

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Plasmalogen lipids: functional mechanism and their involvement in gastrointestinal cancer (2018)

Márcia Cristina Fernandes Messias, Giovana Colozza Mecatti, Denise Gonçalves Priolli and Patrícia de Oliveira Carvalho

BioMed Central

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Publication Date: 2018-03-09

Description: The plasmalogens are a class of glycerophospholipids which contain a vinyl-ether and an ester bond at the sn-1 and sn-2 positions, respectively, in the glycerol backbone. They constitute 10 mol% of the total mass...

Electronic ISSN: 1476-511X

Topics: Biology

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Association between apolipoprotein B genetic polymorphism and the risk of calcific aortic stenosis in Chinese subjects, in Xinjiang, China (2018)

Yong-Tao Wang, Yang Li, Yi-Tong Ma, Yi-Ning Yang, Xiang Ma, Xiao-Mei Li, Fen Liu and Bang-Dang Chen

BioMed Central

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Publication Date: 2018-03-09

Description: Limited information is available when it comes to the impact of genetic on Calcific Aortic Stenosis (CAS). Apolipoprotein B (apoB) is a key component in lipid metabolism and plays an important role in the dyna...

Electronic ISSN: 1476-511X

Topics: Biology

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An interpretable framework for clustering single-cell RNA-Seq datasets (2018)

Jesse M. Zhang, Jue Fan, H. Christina Fan, David Rosenfeld and David N. Tse

BioMed Central

In: BMC Bioinformatics

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Publication Date: 2018-03-12

Description: With the recent proliferation of single-cell RNA-Seq experiments, several methods have been developed for unsupervised analysis of the resulting datasets. These methods often rely on unintuitive hyperparameter...

Electronic ISSN: 1471-2105

Topics: Biology , Computer Science

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73

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MYC amplification in subtypes of breast cancers in African American women (2018)

Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. De; Witty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi and Jan K. Blancato

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-12

Description: MYC overexpression is associated with poor prognosis in breast tumors (BCa). The objective of this study was to determine the prevalence of MYC amplification and associated markers in BCa tumors from African A...

Electronic ISSN: 1471-2407

Topics: Medicine

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Separation of functionally divergent muscle precursor cell populations from porcine juvenile muscles by discontinuous Percoll density gradient centrifugation (2018)

Claudia Miersch, Katja Stange and Monika Röntgen

BioMed Central

In: BMC Cell Biology

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Publication Date: 2018-03-12

Description: Satellite cells (SC) and their descendants, muscle precursor cells (MPC), play a key role in postnatal muscle development, regeneration, and plasticity. Several studies have provided evidence that SC and MPC r...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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Visual quality assessment of the liver graft by the transplanting surgeon predicts postreperfusion syndrome after liver transplantation: a retrospective cohort study (2018)

Felix Kork, Alexandra Rimek, Anne Andert, Niklas Jurek Becker, Christoph Heidenhain, Ulf P. Neumann, Daniela Kroy, Anna B. Roehl, Rolf Rossaint and Marc Hein

BioMed Central

In: BMC Anesthesiology

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Publication Date: 2018-03-12

Description: The discrepancy between demand and supply for liver transplants (LT) has led to an increased transplantation of organs from extended criteria donors (ECD).

Electronic ISSN: 1471-2253

Topics: Medicine

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76

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Fast and efficient short read mapping based on a succinct hash index (2018)

Haowen Zhang, Yuandong Chan, Kaichao Fan, Bertil Schmidt and Weiguo Liu

BioMed Central

In: BMC Bioinformatics

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Publication Date: 2018-03-12

Description: Various indexing techniques have been applied by next generation sequencing read mapping tools. The choice of a particular data structure is a trade-off between memory consumption, mapping throughput, and cons...

Electronic ISSN: 1471-2105

Topics: Biology , Computer Science

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Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas (2018)

Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen and Bjarne W. Kristensen

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-12

Description: We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-bindin...

Electronic ISSN: 1471-2407

Topics: Medicine

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Textpresso Central: a customizable platform for searching, text mining, viewing, and curating biomedical literature (2018)

H.-M. Müller, K. M. Van Auken, Y. Li and P. W. Sternberg

BioMed Central

In: BMC Bioinformatics

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Publication Date: 2018-03-12

Description: The biomedical literature continues to grow at a rapid pace, making the challenge of knowledge retrieval and extraction ever greater. Tools that provide a means to search and mine the full text of literature t...

Electronic ISSN: 1471-2105

Topics: Biology , Computer Science

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Relationship between self-efficacy, self-care behaviour and glycaemic control among patients with type 2 diabetes mellitus in the Malaysian primary care setting (2018)

Zahirah Tharek, Anis Safura Ramli, David Leonard Whitford, Zaliha Ismail, Maryam Mohd Zulkifli, Siti Khuzaimah Ahmad Sharoni, Asrul Akmal Shafie and Thevaraajan Jayaraman

BioMed Central

In: BMC Family Practice

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Publication Date: 2018-03-12

Description: Self-efficacy has been shown to be positively correlated with self-care behaviour and glycaemic control among patients with type 2 diabetes mellitus. However, such evidence is lacking in the Malaysian primary ...

Electronic ISSN: 1471-2296

Topics: Medicine

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80

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The role of the general practitioner in multidisciplinary teams: a qualitative study in elderly care (2018)

Sietske M. Grol, Gerard R. M. Molleman, Anne Kuijpers, Rob van der Sande, Gerdine A. J. Fransen, Willem J. J. Assendelft and Henk J. Schers

BioMed Central

In: BMC Family Practice

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Publication Date: 2018-03-12

Description: In the western world, a growing number of the older people live at home. In the Netherlands, GPs are expected to play a pivotal role in the organization of integrated care for this patient group. However, litt...

Electronic ISSN: 1471-2296

Topics: Medicine

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81

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Identification, characterization and gene expression analyses of important flowering genes related to photoperiodic pathway in bamboo (2018)

Smritikana Dutta, Prasun Biswas, Sukanya Chakraborty, Devrani Mitra, Amita Pal and Malay Das

BioMed Central

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Publication Date: 2018-03-12

Description: Bamboo is an important member of the family Poaceae and has many inflorescence and flowering features rarely observed in other plant groups. It retains an unusual form of perennialism by having a long vegetati...

Electronic ISSN: 1471-2164

Topics: Biology

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82

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An assessment of the malaria-related knowledge and practices of Tanzania’s drug retailers: exploring the impact of drug store accreditation (2018)

Rebecca Thomson, Boniface Johanes, Charles Festo, Admirabilis Kalolella, Mark Taylor, Sarah Tougher, Yazoume Ye, Andrea Mann, Ruilin Ren, Katia Bruxvoort, Barbara Willey, Fred Arnold, Kara Hanson and Catherine Goodman

BioMed Central

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Publication Date: 2018-03-12

Description: Since 2003 Tanzania has upgraded its approximately 7000 drug stores to Accredited Drug Dispensing Outlets (ADDOs), involving dispenser training, introduction of record keeping and enhanced regulation. Prior to...

Electronic ISSN: 1472-6963

Topics: Medicine

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83

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Relationship of aging, skeletal muscle mass, and tooth loss with masseter muscle thickness (2018)

Kohei Yamaguchi, Haruka Tohara, Koji Hara, Ayako Nakane, Eriko Kajisa, Kanako Yoshimi and Shunsuke Minakuchi

BioMed Central

In: BMC Geriatrics

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Publication Date: 2018-03-12

Description: Previous studies have reported a relationship between masseter muscle thickness and tooth loss or limb muscle thickness. However, it is not yet known whether masseter muscle thickness is related to appendicula...

Electronic ISSN: 1471-2318

Topics: Medicine

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Changes in MLST profiles and biotypes of Corynebacterium diphtheriae isolates from the diphtheria outbreak period to the period of invasive infections caused by nontoxigenic strains in Poland (1950–2016) (2018)

Urszula Czajka, Aldona Wiatrzyk, Ewa Mosiej, Kamila Formińska and Aleksandra A. Zasada

BioMed Central

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Publication Date: 2018-03-12

Description: Corynebacterium diphtheriae is a re-emerging pathogen in Europe causing invasive infections in vaccinated persons and classical diphtheria in unvaccinated persons. In the presented study we analysed genetic chang...

Electronic ISSN: 1471-2334

Topics: Medicine

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85

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Using normalisation process theory to evaluate the implementation of a complex intervention to embed the surgical safety checklist (2018)

Brigid M. Gillespie, Emma Harbeck, Joanne Lavin, Therese Gardiner, Teresa K. Withers and Andrea P. Marshall

BioMed Central

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Publication Date: 2018-03-12

Description: The surgical Safety Checklist (SSC) was introduced in 2008 to improve teamwork and reduce the mortality and morbidity associated with surgery. Although mandated in many health care institutions around the worl...

Electronic ISSN: 1472-6963

Topics: Medicine

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86

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Compassionate use programs in Italy: ethical guidelines (2018)

Ludovica De Panfilis, Roberto Satolli and Massimo Costantini

BioMed Central

In: BMC Medical Ethics

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Publication Date: 2018-03-12

Description: This article proposes a retrospective analysis of a compassionate use (CU), using a case study of request for Avelumab for a patient suffering from Merkel Cell Carcinoma. The study is the result of a discussio...

Electronic ISSN: 1472-6939

Topics: Medicine , Philosophy

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Cost-effectiveness in extracorporeal life support in critically ill adults in the Netherlands (2018)

Annemieke Oude Lansink-Hartgring, Dinis Dos Reis Miranda, Dirk W. Donker, Jacinta J. Maas, Thijs Delnoij, Marijn Kuijpers, Judith van den Brule, Erik Scholten, Hendrik Endeman, Alexander P. J. Vlaar and Walter M. van den Bergh

BioMed Central

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Publication Date: 2018-03-12

Description: Extracorporeal life support (ECLS) is used to support the cardiorespiratory function in case of severe cardiac and/or respiratory failure in critically ill patients. According to the ELSO guidelines ECLS shoul...

Electronic ISSN: 1472-6963

Topics: Medicine

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