CaRLO

2

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An automated pipeline for bouton, spine, and synapse detection of in vivo two-photon images (2018)

Qiwei Xie, Xi Chen, Hao Deng, Danqian Liu, Yingyu Sun, Xiaojuan Zhou, Yang Yang and Hua Han

BioMed Central

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Publication Date: 2018-03-06

Description: In the nervous system, the neurons communicate through synapses. The size, morphology, and connectivity of these synapses are significant in determining the functional properties of the neural network. Therefo...

Electronic ISSN: 1756-0381

Topics: Biology , Computer Science

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A novel joint analysis framework improves identification of differentially expressed genes in cross disease transcriptomic analysis (2018)

Wenyi Qin and Hui Lu

BioMed Central

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Publication Date: 2018-03-06

Description: Detecting differentially expressed (DE) genes between disease and normal control group is one of the most common analyses in genome-wide transcriptomic data. Since most studies don’t have a lot of samples, res...

Electronic ISSN: 1756-0381

Topics: Biology , Computer Science

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Identification of influential observations in high-dimensional cancer survival data through the rank product test (2018)

Eunice Carrasquinha, André Veríssimo, Marta B. Lopes and Susana Vinga

BioMed Central

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Publication Date: 2018-03-06

Description: Survival analysis is a statistical technique widely used in many fields of science, in particular in the medical area, and which studies the time until an event of interest occurs. Outlier detection in this co...

Electronic ISSN: 1756-0381

Topics: Biology , Computer Science

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Scalable non-negative matrix tri-factorization (2018)

Andrej Čopar, Marinka žitnik and Blaž Zupan

BioMed Central

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Publication Date: 2018-03-06

Description: Matrix factorization is a well established pattern discovery tool that has seen numerous applications in biomedical data analytics, such as gene expression co-clustering, patient stratification, and gene-disea...

Electronic ISSN: 1756-0381

Topics: Biology , Computer Science

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Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain (2018)

Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick and Rafael Franco

BioMed Central

In: BMC Biology

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Publication Date: 2018-03-06

Description: G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (...

Electronic ISSN: 1741-7007

Topics: Biology

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Measuring behavior across scales (2018)

Gordon J. Berman

BioMed Central

In: BMC Biology

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Publication Date: 2018-03-06

Description: The need for high-throughput, precise, and meaningful methods for measuring behavior has been amplified by our recent successes in measuring and manipulating neural circuitry. The largest challenges associated...

Electronic ISSN: 1741-7007

Topics: Biology

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Human S100A5 binds Ca2+ and Cu2+ independently (2018)

Lucas C. Wheeler and Michael J. Harms

BioMed Central

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Publication Date: 2018-03-06

Description: S100A5 is a calcium binding protein found in a small subset of amniote tissues. Little is known about the biological roles of S100A5, but it may be involved in inflammation and olfactory signaling. Previous wo...

Electronic ISSN: 2046-1682

Topics: Biology , Physics

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Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics (2018)

D. A. Doronin, N. V. Barykina, O. M. Subach, V. P. Sotskov, V. V. Plusnin, O. A. Ivleva, E. A. Isaakova, A. M. Varizhuk, G. E. Pozmogova, A. Y. Malyshev, I. V. Smirnov, K. D. Piatkevich, K. V. Anokhin, G. N. Enikolopov and F. V. Subach

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: The recently developed genetically encoded calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca2+-binding moiety inserted into the mNeonGr...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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10

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Effects of substrate binding site residue substitutions of xynA from Bacillus amyloliquefaciens on substrate specificity (2018)

Anil S. Prajapati, Vishakha A. Pawar, Ketankumar J. Panchal, Ankit P. Sudhir, Bhaumik R. Dave, Darshan H. Patel and R. B. Subramanian

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: The aromatic residues of xylanase enzyme, W187, Y124, W144, Y128 and W63 of substrate binding pocket from Bacillus amyloliquefaciens were investigated for their role in substrate binding by homology modelling and...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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11

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Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma (2018)

Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao and Weimin Mao

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.

Electronic ISSN: 1471-2407

Topics: Medicine

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CMR stress testing in a patient with morbid obesity (BMI 58 kg/m2) and suspected coronary artery disease (2018)

Lukas Stoiber, Bernhard Schnackenburg, Rolf Gebker, Hanane Hireche-Chikaoui, Burkert Pieske and Sebastian Kelle

BioMed Central

In: BMC Cardiovascular Disorders

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Publication Date: 2018-03-06

Description: Severe obesity is asscociated with an increased risk of coronary artery disease (CAD) but non-invasive cardiac imaging modalities have important technical limits.

Electronic ISSN: 1471-2261

Topics: Medicine

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Combined value of left ventricular ejection fraction and the Model for End-Stage Liver Disease (MELD) score for predicting mortality in patients with acute coronary syndrome who were undergoing percutaneous coronary intervention (2018)

Tuncay Kırıs, Eyüp Avcı and Aykan Çelik

BioMed Central

In: BMC Cardiovascular Disorders

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Publication Date: 2018-03-06

Description: The purpose of the study was to investigate whether the addition of left ventricular ejection fraction (LVEF) to the MELD score enhances the prediction of mortality in patients with acute coronary syndrome (AC...

Electronic ISSN: 1471-2261

Topics: Medicine

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Mechanically tuned 3 dimensional hydrogels support human mammary fibroblast growth and viability (2018)

Kathryn Woods, Catlyn Thigpen, Jennifer Peyling Wang, Hana Park and Abigail Hielscher

BioMed Central

In: BMC Cell Biology

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Publication Date: 2018-03-06

Description: Carcinoma associated fibroblasts (CAFs or myofibroblasts) are activated fibroblasts which participate in breast tumor growth, angiogenesis, invasion, metastasis and therapy resistance. As such, recent efforts ...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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Phytochemical profiling and in vitro screening for anticholinesterase, antioxidant, antiglucosidase and neuroprotective effect of three traditional medicinal plants for Alzheimer’s Disease and Diabetes Mellitus dual therapy (2018)

Mohan Penumala, Raveendra Babu Zinka, Jeelan Basha Shaik, Suresh Kumar Reddy Mallepalli, Ramakrishna Vadde and Damu Gangaiah Amooru

BioMed Central

In: BMC Complementary and Alternative Medicine

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Publication Date: 2018-03-06

Description: Extensive epidemiological and clinical studies revealed that Alzheimer’s Disease (AD) and Type 2 Diabetes Mellitus (T2D) are most likely to appear simultaneously in aged people as T2D is a major risk factor fo...

Electronic ISSN: 1472-6882

Topics: Medicine

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Can an app supporting psoriasis patients improve adherence to topical treatment? A single-blind randomized controlled trial (2018)

Mathias Tiedemann Svendsen, Flemming Andersen, Kirsten Hammond Andersen and Klaus Ejner Andersen

BioMed Central

In: BMC Dermatology

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Publication Date: 2018-03-06

Description: Topical corticosteroid or corticosteroid/calcipotriol preparations are recommended first-line topical treatments of psoriasis, but a main cause for the lack of efficacy of topical treatments is considered low ...

Electronic ISSN: 1471-5945

Topics: Medicine

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17

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Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity (2018)

Shasha Xu, Shaoang Tu, Jinlong Gao, Jia Liu, Zhirui Guo, Jinming Zhang, Xingdang Liu, Jianhui Liang, Yiyun Huang and Mei Han

BioMed Central

In: BMC Complementary and Alternative Medicine

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Publication Date: 2018-03-06

Description: Methamphetamine (METH) is a psychostimulant with high abuse liability that affects the monoamine neurotransmitter systems, particularly the dopamine system. Currently there are no effective medications for the...

Electronic ISSN: 1472-6882

Topics: Medicine

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18

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Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos (2018)

Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu and Jen-Her Lu

BioMed Central

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Publication Date: 2018-03-06

Description: Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growt...

Electronic ISSN: 1471-213X

Topics: Biology , Medicine

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19

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Generic quality of life in persons with hearing loss: a systematic literature review (2018)

Øyvind Nordvik, Peder O. Laugen Heggdal, Jonas Brännström, Flemming Vassbotn, Anne Kari Aarstad and Hans Jørgen Aarstad

BioMed Central

In: BMC Ear, Nose and Throat Disorders

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Publication Date: 2018-03-06

Description: To the best of our knowledge, no empirically based consensus has been reached as to if, and to what extent, persons with hearing loss (HL) have reduced generic Quality of life (QoL). There seems to be limited ...

Electronic ISSN: 1472-6815

Topics: Medicine

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20

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High inter-observer agreement of observer-perceived pain assessment in the emergency department (2018)

Martin Høhrmann Hangaard, Brian Malling and Christian Backer Mogensen

BioMed Central

In: BMC Emergency Medicine

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Publication Date: 2018-03-06

Description: Triage is used to prioritize the patients in the emergency department. The majority of the triage systems include the patients’ pain score to assess their level of acuity by using a combination of patient repo...

Electronic ISSN: 1471-227X

Topics: Medicine

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21

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Causes of higher symptomatic airway load in patients with chronic rhinosinusitis (2018)

Øystein Eskeland, Kjell Arild Danielsen, Fredrik Dahl, Katrin Fridrich, Vivian Cecilie Orszagh, Gregor Bachmann-Harildstad and Espen Burum-Auensen

BioMed Central

In: BMC Ear, Nose and Throat Disorders

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Publication Date: 2018-03-06

Description: Chronic rhinosinusitis display a variety of different phenotypes. The symptoms of disease are characterised by various signs and symptoms such as nasal congestion, nasal discharge, pressure sensation in the fa...

Electronic ISSN: 1472-6815

Topics: Medicine

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The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population (2018)

Jainagul Isakova, Elnura Talaibekova, Denis Vinnikov, Nazira Aldasheva, Erkin Mirrakhimov and Almaz Aldashev

BioMed Central

In: BMC Endocrine Disorders

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Publication Date: 2018-03-06

Description: The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population.

Electronic ISSN: 1472-6823

Topics: Medicine

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23

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Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment (2018)

Tao Tao, Peihong Wu, Yuying Wang and Wei Liu

BioMed Central

In: BMC Endocrine Disorders

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Publication Date: 2018-03-06

Description: Impaired insulin activity in women with polycystic ovary syndrome might differ from that seen in type 2 diabetes mellitus without polycystic ovary syndrome. This study was designed to compare the effects of tr...

Electronic ISSN: 1472-6823

Topics: Medicine

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24

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Disentangling the effect of illness perceptions on health status in people with type 2 diabetes after an acute coronary event (2018)

Rimke Cathelijne Vos, Marise Jeannine Kasteleyn, Monique Johanna Heijmans, Elke de Leeuw, François Georges Schellevis, Mieke Rijken and Guy Emile Rutten

BioMed Central

In: BMC Family Practice

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Publication Date: 2018-03-06

Description: Chronically ill patients such as people with type 2 diabetes develop perceptions of their illness, which will influence their coping behaviour. Perceptions are formed once a health threat has been recognised. ...

Electronic ISSN: 1471-2296

Topics: Medicine

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25

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Complete mitochondrial genomes of Nanorana taihangnica and N. yunnanensis (Anura: Dicroglossidae) with novel gene arrangements and phylogenetic relationship of Dicroglossidae (2018)

Jia-Yong Zhang, Le-Ping Zhang, Dan-Na Yu, Kenneth B. Storey and Rong-Quan Zheng

BioMed Central

In: BMC Evolutionary Biology

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Publication Date: 2018-03-06

Description: Complete mitochondrial (mt) genomes have been used extensively to test hypotheses about microevolution and to study population structure, phylogeography, and phylogenetic relationships of Anura at various taxo...

Electronic ISSN: 1471-2148

Topics: Biology

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26

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The role of facial pattern variation for species recognition in red-fronted lemurs (Eulemur rufifrons) (2018)

Hanitriniaina Rakotonirina, Peter M. Kappeler and Claudia Fichtel

BioMed Central

In: BMC Evolutionary Biology

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Publication Date: 2018-03-06

Description: Species recognition, i.e., the ability to distinguish conspecifics from heterospecifics, plays an essential role in reproduction. The role of facial cues for species recognition has been investigated in severa...

Electronic ISSN: 1471-2148

Topics: Biology

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27

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Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients (2018)

Thorbjørn Søren Rønn Jensen, Badar Mahmood, Morten Bach Damm, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Mark Berner Hansen and Niels Bindslev

BioMed Central

In: BMC Gastroenterology

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Publication Date: 2018-03-06

Description: Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 is thought to be the predominant COX isozyme involved in neoplasia. Meanwhile...

Electronic ISSN: 1471-230X

Topics: Medicine

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28

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Synaptic neuron-astrocyte communication is supported by an order of magnitude analysis of inositol tris-phosphate diffusion at the nanoscale in a model of peri-synaptic astrocyte projection (2018)

Pavel Montes de Oca Balderas and Horacio Montes de Oca Balderas

BioMed Central

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Publication Date: 2018-03-06

Description: Astrocytes were conceived for decades only as supporting cells of the brain. However, the observation of Ca2+ waves in astrocyte synctitia, their neurotransmitter receptor expression and gliotransmitter secret...

Electronic ISSN: 2046-1682

Topics: Biology , Physics

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29

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Kinetic and thermodynamic studies reveal chemokine homologues CC11 and CC24 with an almost identical tertiary structure have different folding pathways (2018)

Baosheng Ge, Xiaoyong Jiang, Yao Chen, Tingting Sun, Qiuxia Yang and Fang Huang

BioMed Central

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Publication Date: 2018-03-06

Description: Proteins with low sequence identity but almost identical tertiary structure and function have been valuable to uncover the relationship between sequence, tertiary structure, folding mechanism and functions. Tw...

Electronic ISSN: 2046-1682

Topics: Biology , Physics

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30

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GPMVs in variable physiological conditions: could they be used for therapy delivery? (2018)

Špela Zemljič Jokhadar, Urška Klančnik, Maja Grundner, Tjaša Švelc Kebe, Saša Vrhovec Hartman, Mirjana Liović and Jure Derganc

BioMed Central

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Publication Date: 2018-03-06

Description: Cell based carriers are increasingly recognized as a good system for cargo delivery to cells. One of the reasons is their biocompatibility and low toxicity compared to artificial systems. Giant plasma membrane...

Electronic ISSN: 2046-1682

Topics: Biology , Physics

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DNA methylome profiling at single-base resolution through bisulfite sequencing of 5mC-immunoprecipitated DNA (2018)

Zhen Jia, Yueyi Shi, Lei Zhang, Yipeng Ren, Tong Wang, Lejun Xing, Baorong Zhang, Guolan Gao and Rongfa Bu

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect DNA methylation genome-w...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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32

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Mixed response on regorafenib treatment for GIST (gastro-intestinal stromal tumor) according to 18F–FDG-PET/CT (2018)

Donatienne Van Weehaeghe, Olivier Gheysens, Vincent Vandecaveye, Patrick Schöffski, Koen Van Laere and Christophe M. Deroose

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Gastro-intestinal stromal tumors (GISTs) are very rare tumors of the gastro-intestinal tract, originating from the interstitial cells of Cajal or a common cell precursor which both express type III tyrosine ki...

Electronic ISSN: 1471-2407

Topics: Medicine

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Detection and interval cancer rates during the transition from screen-film to digital mammography in population-based screening (2018)

Valérie D. V. Sankatsing, Jacques Fracheboud, Linda de Munck, Mireille J. M. Broeders, Nicolien T. van Ravesteyn, Eveline A. M. Heijnsdijk, André L. M. Verbeek, Johannes D. M. Otten, Ruud M. Pijnappel, Sabine Siesling and Harry J. de Koning

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Between 2003 and 2010 digital mammography (DM) gradually replaced screen-film mammography (SFM) in the Dutch breast cancer screening programme (BCSP). Previous studies showed increases in detection rate (DR) a...

Electronic ISSN: 1471-2407

Topics: Medicine

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Percutaneous closure versus medical therapy for stroke with patent foramen Ovale: a systematic review and meta-analysis (2018)

Xin-Lin Zhang, Li-Na Kang, Lian Wang and Biao Xu

BioMed Central

In: BMC Cardiovascular Disorders

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Publication Date: 2018-03-06

Description: Patent foramen ovale (PFO) closure has emerged as a secondary prevention option in patients with PFO and cryptogenic stroke. However, the comparative efficacy and safety of percutaneous closure and medical the...

Electronic ISSN: 1471-2261

Topics: Medicine

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35

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MicroRNA-17-5p aggravates lipopolysaccharide-induced injury in nasal epithelial cells by targeting Smad7 (2018)

Nan Huang, Wenjing Li, Xiaolong Wang and Shanshan Qi

BioMed Central

In: BMC Cell Biology

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Publication Date: 2018-03-06

Description: Globally, rhinitis is one of the most common chronic disorders. Despite availability of drugs to manage the symptomatology of rhinitis, researchers still focus on identification of novel molecular targets for ...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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36

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Evaluation of SD BIOLINE H. pylori Ag rapid test against double ELISA with SD H. pylori Ag ELISA and EZ-STEP H. pylori Ag ELISA tests (2018)

Markos Negash, Afework Kassu, Bemnet Amare, Gizachew Yismaw and Beyene Moges

BioMed Central

In: BMC Clinical Pathology

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Publication Date: 2018-03-06

Description: Helicobacter pylori antibody titters fall very slowly even after successful treatment. Therefore, tests detecting H. pylori antibody lack specificity and sensitivity. On the other hand, H. pylori stool antigen te...

Electronic ISSN: 1472-6890

Topics: Medicine

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A novel interaction between kinase activities in regulation of cilia formation (2018)

Nicole De; Vaul, Katerina Koloustroubis, Rong Wang and Ann O. Sperry

BioMed Central

In: BMC Cell Biology

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Publication Date: 2018-03-06

Description: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of pri...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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Primary hepatic neuroendocrine carcinoma: report of two cases and literature review (2018)

Zi-Ming Zhao, Jin Wang, Ugochukwu C. Ugwuowo, Liming Wang and Jeffrey P. Townsend

BioMed Central

In: BMC Clinical Pathology

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Publication Date: 2018-03-06

Description: Primary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare. The diagnosis of PHNEC remains challenging—partly due to its rarity, and partly due to its lack of unique clinical features. Available treatm...

Electronic ISSN: 1472-6890

Topics: Medicine

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39

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Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties (2018)

Habib Mosbah, Hassiba Chahdoura, Jannet Kammoun, Malek Besbes Hlila, Hanen Louati, Saoussen Hammami, Guido Flamini, Lotfi Achour and Boulbaba Selmi

BioMed Central

In: BMC Complementary and Alternative Medicine

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Publication Date: 2018-03-06

Description: α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that cataly...

Electronic ISSN: 1472-6882

Topics: Medicine

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A novel PLEC nonsense homozygous mutation (c.7159G 〉 T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report (2018)

Zoe Argyropoulou, Lu Liu, Linda Ozoemena, Claudia C. Branco, Raquel Senra, Ângela Reis-Rego and Luisa Mota-Vieira

BioMed Central

In: BMC Dermatology

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Publication Date: 2018-03-06

Description: Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM #226670) is an autosomal recessive disease, characterized mainly by skin blistering at birth or shortly thereafter, progressive muscle weakne...

Electronic ISSN: 1471-5945

Topics: Medicine

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41

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A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction? (2018)

Denis Miyashiro, Ana Paula Vieira, Maria Angela Bianconcini Trindade, João Avancini, José Antonio Sanches and Gil Benard

BioMed Central

In: BMC Dermatology

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Publication Date: 2018-03-06

Description: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis...

Electronic ISSN: 1471-5945

Topics: Medicine

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42

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Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells (2018)

Anna Mantsoki, Guillaume Devailly and Anagha Joshi

BioMed Central

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Publication Date: 2018-03-06

Description: Mammalian embryonic stem cells display a unique epigenetic and transcriptional state to facilitate pluripotency by maintaining lineage-specification genes in a poised state. Two epigenetic and transcription pr...

Electronic ISSN: 1471-213X

Topics: Biology , Medicine

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43

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Opsin expression patterns coincide with photoreceptor development during pupal development in the honey bee, Apis mellifera (2018)

Leonie Lichtenstein, Kornelia Grübel and Johannes Spaethe

BioMed Central

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Publication Date: 2018-03-06

Description: The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Differe...

Electronic ISSN: 1471-213X

Topics: Biology , Medicine

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44

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Evidence for a centrosome-attracting body like structure in germ-soma segregation during early development, in the urochordate Oikopleura dioica (2018)

Lisbeth Charlotte Olsen, Ioannis Kourtesis, Henriette Busengdal, Marit Flo Jensen, Harald Hausen and Daniel Chourrout

BioMed Central

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Publication Date: 2018-03-06

Description: Germ cell formation has been investigated in sessile forms of tunicates. This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells ...

Electronic ISSN: 1471-213X

Topics: Biology , Medicine

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45

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A comparison of symptoms and quality of life before and after nasal septoplasty and radiofrequency therapy of the inferior turbinate (2018)

Ann Helen Nilsen, Anne-Sofie Helvik, Wenche Moe Thorstensen and Vegard Bugten

BioMed Central

In: BMC Ear, Nose and Throat Disorders

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Publication Date: 2018-03-06

Description: The primary goal of this study is to compare pre- and postoperative symptoms and health related quality of life (HQOL) in 57 patients who underwent septoplasty (group-1), 56 patients who underwent septoplasty ...

Electronic ISSN: 1472-6815

Topics: Medicine

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46

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A case of an infant suspected as IMAGE syndrome who were finally diagnosed with MIRAGE syndrome by targeted Mendelian exome sequencing (2018)

Yoon-Myung Kim, Go Hun Seo, Gu-Hwan Kim, Jung Min Ko, Jin-Ho Choi and Han-Wook Yoo

BioMed Central

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Publication Date: 2018-03-06

Description: Adrenal hypoplasia is a rare congenital disorder, which can be classified into a non-syndromic form, without extra-adrenal features, and a syndromic form, with such features. Despite biochemical and molecular ...

Electronic ISSN: 1471-2350

Topics: Biology , Medicine

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47

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Rubinstein-Taybi 2 associated to novel EP300 mutations: deepening the clinical and genetic spectrum (2018)

María López, Alberto García-Oguiza, Judith Armstrong, Inmaculada García-Cobaleda, Sixto García-Miñaur, Fernando Santos-Simarro, Verónica Seidel and Elena Domínguez-Garrido

BioMed Central

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Publication Date: 2018-03-06

Description: Rubinstein-Taybi syndrome (RSTS) is a rare autosomal dominant neurodevelopmental disorder characterized by broad thumbs and halluces. RSTS is caused by mutations in CREBBP and in EP300 genes in 50–60% and 8%, res...

Electronic ISSN: 1471-2350

Topics: Biology , Medicine

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48

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What to consider when pseudohypoparathyroidism is ruled out: iPPSD and differential diagnosis (2018)

Arrate Pereda, Intza Garin and Guiomar Perez de Nanclares

BioMed Central

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Publication Date: 2018-03-06

Description: Pseudohypoparathyroidism (PHP) is a rare disease whose phenotypic features are rather difficult to identify in some cases. Thus, although these patients may present with the Albright’s hereditary osteodystroph...

Electronic ISSN: 1471-2350

Topics: Biology , Medicine

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49

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Investigations of organ and effective doses of abdominal cone-beam computed tomography during transarterial chemoembolization using Monte Carlo simulation (2018)

Yi-Shuan Hwang, Hui-Yu Tsai, Yu-Ying Lin and Kar-Wai Lui

BioMed Central

In: BMC Medical Imaging

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Publication Date: 2018-03-06

Description: To investigate the organ dose, effective dose (ED), conversion factor, and the C-arm rotation angle effects on dose variations of abdominal C-arm cone-beam computed tomography (CBCT) during transarterial chemo...

Electronic ISSN: 1471-2342

Topics: Biology

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50

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Presentation of laboratory test results in patient portals: influence of interface design on risk interpretation and visual search behaviour (2018)

Paolo Fraccaro, Markel Vigo, Panagiotis Balatsoukas, Sabine N. van der Veer, Lamiece Hassan, Richard Williams, Grahame Wood, Smeeta Sinha, Iain Buchan and Niels Peek

BioMed Central

In: BMC Medical Informatics and Decision Making

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Publication Date: 2018-03-06

Description: Patient portals are considered valuable instruments for self-management of long term conditions, however, there are concerns over how patients might interpret and act on the clinical information they access. W...

Electronic ISSN: 1472-6947

Topics: Computer Science , Medicine

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51

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Correction to: Multiple Score Comparison: a network meta-analysis approach to comparison and external validation of prognostic scores (2018)

Sarah R. Haile, Beniamino Guerra, Joan B. Soriano and Milo A. Puhan

BioMed Central

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Publication Date: 2018-03-06

Description: Following publication of the original article [1], a member of the writing group reported that his name is misspelt. The paper should appear in Pubmed under “Ter Riet G”, bot as “Riet GT”.

Electronic ISSN: 1471-2288

Topics: Medicine

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52

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DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network (2018)

Jared L. Katzman, Uri Shaham, Alexander Cloninger, Jonathan Bates, Tingting Jiang and Yuval Kluger

BioMed Central

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Publication Date: 2018-03-06

Description: Medical practitioners use survival models to explore and understand the relationships between patients’ covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Stand...

Electronic ISSN: 1471-2288

Topics: Medicine

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53

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Value of information methods to design a clinical trial in a small population to optimise a health economic utility function (2018)

Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar and Nigel Stallard

BioMed Central

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Publication Date: 2018-03-06

Description: Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided...

Electronic ISSN: 1471-2288

Topics: Medicine

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Adaptive designs in clinical trials: why use them, and how to run and report them (2018)

Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap and Thomas Jaki

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are of...

Electronic ISSN: 1741-7015

Topics: Medicine

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55

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Exploring the arthritogenicity of Streptococcus dysgalactiae subspecies equisimilis (2018)

Oddvar Oppegaard, Haima Mylvaganam, Steinar Skrede and Bård Reiakvam Kittang

BioMed Central

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Publication Date: 2018-03-06

Description: During the past decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been increasingly recognized as an important human pathogen. Osteoarticular infections is one of the predominant disease manif...

Electronic ISSN: 1471-2180

Topics: Biology

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56

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Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages (2018)

Lucy Cheng, Laura J. Marinelli, Noël Grosset, Sorel T. Fitz-Gibbon, Charles A. Bowman, Brian Q. Dang, Daniel A. Russell, Deborah Jacobs-Sera, Baochen Shi, Matteo Pellegrini, Jeff F. Miller, Michel Gautier, Graham F. Hatfull and Robert L. Modlin

BioMed Central

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Publication Date: 2018-03-06

Description: A remarkable exception to the large genetic diversity often observed for bacteriophages infecting a specific bacterial host was found for the Cutibacterium acnes (formerly Propionibacterium acnes) phages, which a...

Electronic ISSN: 1471-2180

Topics: Biology

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Nutrient depletion and TOR inhibition induce 18S and 25S ribosomal RNAs resistant to a 5′-phosphate-dependent exonuclease in Candida albicans and other yeasts (2018)

Jacob Fleischmann and Miguel A. Rocha

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Messenger RNA (mRNA) represents a small percentage of RNAs in a cell, with ribosomal RNA (rRNA) making up the bulk of it. To isolate mRNA from eukaryotes, typically poly-A selection is carried out. Recently, a...

Electronic ISSN: 1471-2199

Topics: Biology

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58

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Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939 (2018)

Jun Yang, Yan Liu, Bing Wang, Hongzhen Lan, Ying Liu, Fei Chen, Ju Zhang and Jian Luo

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Cholangiocarcinoma is one of the deadly disease with poor 5-year survival and poor response to conventional therapies. Previously, we found that p27kip1 nuclear-cytoplasmic translocation confers proliferation ...

Electronic ISSN: 1471-2199

Topics: Biology

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59

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Incidence of distal radius fracture surgery in Finns aged 50 years or more between 1998 and 2016 – too many patients are yet operated on? (2018)

Teemu P. Hevonkorpi, Antti P. Launonen, Tuomas T. Huttunen, Pekka Kannus, Seppo Niemi and Ville M. Mattila

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: Although optimal treatment of distal radius fractures is controversial, surgery has gained popularity. The purpose of this study was to evaluate recent trends in the surgical treatment of distal radius fractur...

Electronic ISSN: 1471-2474

Topics: Medicine

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60

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What factors impact on the implementation of clubfoot treatment services in low and middle-income countries?: a narrative synthesis of existing qualitative studies (2018)

Sarah Drew, Rachael Gooberman-Hill and Christopher Lavy

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: Around 100,000 children are born annually with clubfoot worldwide and 80% live in low and middle-income counties (LMICs). Clubfoot is a condition in which children are born with one or both feet twisted inward...

Electronic ISSN: 1471-2474

Topics: Medicine

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61

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Quality of life in hemodialysis diabetic patients: a multicenter cross-sectional study from Palestine (2018)

Sohaib T. Khatib, Mohammad K. Hemadneh, Samer A. Hasan, Emad Khazneh and Sa’ed H. Zyoud

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-06

Description: Both diabetes and hemodialysis can seriously impair patients’ health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in he...

Electronic ISSN: 1471-2369

Topics: Medicine

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62

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Treatment outcomes and factors affecting unsuccessful outcome among new pulmonary smear positive and negative tuberculosis patients in Anqing, China: a retrospective study (2018)

Yufeng Wen, Zhiping Zhang, Xianxiang Li, Dan Xia, Jun Ma, Yuanyuan Dong and Xinwei Zhang

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Monitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program...

Electronic ISSN: 1471-2334

Topics: Medicine

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Household contact non-attendance of clinical evaluation for tuberculosis: a pilot study in a high burden district in South Africa (2018)

Gladys Kigozi, Michelle Engelbrecht, Christo Heunis and André Janse van Rensburg

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: In 2012, the World Health Organization launched guidelines for systematically investigating contacts of persons with infectious tuberculosis (TB) in low- and middle-income countries. As such, it is necessary t...

Electronic ISSN: 1471-2334

Topics: Medicine

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What do medical students know about e-cigarettes? A cross-sectional survey from one U.S. medical school (2018)

Katie Hinderaker, David V. Power, Sharon Allen, Ellen Parker and Kolawole Okuyemi

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Although electronic cigarette (e-cigarette) use has rapidly increased, there is little data about what United States medical students know or are taught about them. This study examined medical students’ experi...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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65

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Does the Stockholm Syndrome affect female sex workers? The case for a “Sonagachi Syndrome” (2018)

Abraar Karan and Nathan Hansen

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-06

Description: Female sex workers are subjected to intense physical, sexual, and mental abuses that are well documented in the medical and public health literature. However, less well-studied are the mental coping mechanisms...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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Effects of a work-based critical reflection program for novice nurses (2018)

Yeon Hee Kim, Ja Min, Soon Hee Kim and Sujin Shin

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Critical reflection is effective in improving students’ communication abilities and confidence. The aim of this study was to evaluate the effectiveness of a work-based critical reflection program to enhance no...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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67

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Screening for infectious diseases of asylum seekers upon arrival: the necessity of the moral principle of reciprocity (2018)

Dorien T. Beeres, Darren Cornish, Machiel Vonk, Sofanne J. Ravensbergen, Els L. M. Maeckelberghe, Pieter Boele Van Hensbroek and Ymkje Stienstra

BioMed Central

In: BMC Medical Ethics

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Publication Date: 2018-03-06

Description: With a large number of forcibly displaced people seeking safety, the EU is facing a challenge in maintaining solidarity. Europe has seen millions of asylum seekers crossing European borders, the largest number...

Electronic ISSN: 1472-6939

Topics: Medicine , Philosophy

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68

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Matters to address prior to introducing new life support technology in Japan: three serious ethical concerns related to the use of left ventricular assist devices as destination therapy and suggested policies to deal with them (2018)

Atsushi Asai, Sakiko Masaki, Taketoshi Okita, Aya Enzo and Yasuhiro Kadooka

BioMed Central

In: BMC Medical Ethics

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Publication Date: 2018-03-06

Description: Destination therapy (DT) is the permanent implantation of a left ventricular assist device (LVAD) in patients with end-stage, severe heart failure who are ineligible for heart transplantation. DT improves both...

Electronic ISSN: 1472-6939

Topics: Medicine , Philosophy

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69

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A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy (2018)

Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden…

BioMed Central

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Publication Date: 2018-03-06

Description: Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved ...

Electronic ISSN: 1755-8794

Topics: Medicine

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70

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Primary microcephaly case from the Karachay-Cherkess Republic poses an additional support for microcephaly and Seckel syndrome spectrum disorders (2018)

Andrey V. Marakhonov, Fedor A. Konovalov, Amin Kh. Makaov, Tatyana A. Vasilyeva, Vitaly V. Kadyshev, Varvara A. Galkina, Elena L. Dadali, Sergey I. Kutsev and Rena A. Zinchenko

BioMed Central

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Publication Date: 2018-03-06

Description: Primary microcephaly represents an example of clinically and genetically heterogeneous condition. Here we describe a case of primary microcephaly from the Karachay-Cherkess Republic, which was initially diagno...

Electronic ISSN: 1755-8794

Topics: Medicine

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Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection (2018)

Na Zhang, Yun-Juan Bao, Amy Hin-Yan Tong, Scott Zuyderduyn, Gary D. Bader, J. S. Malik Peiris, Si Lok and Suki Man-Yan Lee

BioMed Central

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Publication Date: 2018-03-06

Description: Avian influenza A H5N1 virus can cause lethal disease in humans. The virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data from clinical, in vitro and in vivo suggest that vi...

Electronic ISSN: 1755-8794

Topics: Medicine

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Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke (2018)

Ani Stepanyan, Roksana Zakharyan, Arsen Simonyan, Gohar Tsakanova and Arsen Arakelyan

BioMed Central

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Publication Date: 2018-03-06

Description: Despite the important role of the nerve growth factor in the survival and maintenance of neurons in ischemic stroke, data regarding the relationships between variations in the encoding gene and stroke are lack...

Electronic ISSN: 1471-2350

Topics: Biology , Medicine

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Medical genomics at Belyaev Conference – 2017 (2018)

Yuriy L. Orlov, Julio R. Fernandez-Masso, Ming Chen and Ancha V. Baranova

BioMed Central

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Publication Date: 2018-03-06

Electronic ISSN: 1755-8794

Topics: Medicine

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74

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Incidental finding of large pneumothorax on Cardiac MR scan (2018)

J. P. M. Andrews, G. McKillop and M. R. Dweck

BioMed Central

In: BMC Medical Imaging

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Publication Date: 2018-03-06

Description: We believe this is the first case report of a pneumothorax being identified using cardiac magnetic resonance imaging. This case also illustrates the haemodynamic effect a large pneumothorax can have on right v...

Electronic ISSN: 1471-2342

Topics: Biology

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Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations (2018)

Jose L. Gomez, Maria P. Diaz, Gustavo Nino and Clemente J. Britto

BioMed Central

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Publication Date: 2018-03-06

Description: Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and adults. Some individuals with asthma have increased su...

Electronic ISSN: 1755-8794

Topics: Medicine

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76

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Cardiovascular magnetic resonance in the evaluation of heart valve disease (2018)

G. S. Gulsin, A. Singh and G. P. McCann

BioMed Central

In: BMC Medical Imaging

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Publication Date: 2018-03-06

Description: Over the last 25 years, cardiovascular magnetic resonance imaging (CMR) has emerged as an alternative to echocardiography for assessment of valvular heart disease (VHD). Although echo remains the first-line im...

Electronic ISSN: 1471-2342

Topics: Biology

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77

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Leveraging healthcare utilization to explore outcomes from musculoskeletal disorders: methodology for defining relevant variables from a health services data repository (2018)

Daniel I. Rhon, Derek Clewley, Jodi L. Young, Charles D. Sissel and Chad E. Cook

BioMed Central

In: BMC Medical Informatics and Decision Making

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Publication Date: 2018-03-06

Description: Large healthcare databases, with their ability to collect many variables from daily medical practice, greatly enable health services research. These longitudinal databases provide large cohorts and longitudina...

Electronic ISSN: 1472-6947

Topics: Computer Science , Medicine

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The management of children with bronchiolitis in the Australasian hospital setting: development of a clinical practice guideline (2018)

Sharon O’Brien, Sally Wilson, Fenella J. Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley and Stuart R Dalziel

BioMed Central

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Publication Date: 2018-03-06

Description: Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation i...

Electronic ISSN: 1471-2288

Topics: Medicine

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Combining information from a clinical data warehouse and a pharmaceutical database to generate a framework to detect comorbidities in electronic health records (2018)

Emmanuelle Sylvestre, Guillaume Bouzillé, Emmanuel Chazard, Cécil His-Mahier, Christine Riou and Marc Cuggia

BioMed Central

In: BMC Medical Informatics and Decision Making

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Publication Date: 2018-03-06

Description: Medical coding is used for a variety of activities, from observational studies to hospital billing. However, comorbidities tend to be under-reported by medical coders. The aim of this study was to develop an a...

Electronic ISSN: 1472-6947

Topics: Computer Science , Medicine

Published by BioMed Central

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Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease (2018)

Beniamino Guerra, Sarah R. Haile, Bernd Lamprecht, Ana S. Ramírez, Pablo Martinez-Camblor, Bernhard Kaiser, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban-González, Juan J. Soler-Cataluña, Juan P. de-Torres, Marc Miravitlles, Bartolome R. Celli, Jose M. Marin, Gerben ter Riet…

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary dise...

Electronic ISSN: 1741-7015

Topics: Medicine

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The Cambridge Prognostic Groups for improved prediction of disease mortality at diagnosis in primary non-metastatic prostate cancer: a validation study (2018)

V. J. Gnanapragasam, O. Bratt, K. Muir, L. S. Lee, H. H. Huang, P. Stattin and A. Lophatananon

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer.

Electronic ISSN: 1741-7015

Topics: Medicine

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Distinct fermentation and antibiotic sensitivity profiles exist in salmonellae of canine and human origin (2018)

Corrin V. Wallis, Preena Lowden, Zoe V. Marshall-Jones and Anthony C. Hilton

BioMed Central

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Publication Date: 2018-03-06

Description: Salmonella enterica is a recognised cause of diarrhoea in dogs and humans, yet the potential for transfer of salmonellosis between dogs and their owners is unclear, with reported evidence both for and against Sal...

Electronic ISSN: 1471-2180

Topics: Biology

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The PhyR homolog RSP_1274 of Rhodobacter sphaeroides is involved in defense of membrane stress and has a moderate effect on RpoE (RSP_1092) activity (2018)

Qingfeng Li, Tao Peng and Gabriele Klug

BioMed Central

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Publication Date: 2018-03-06

Description: A major role of the PhyR-NepR-σ(EcfG) cascade in the general stress response was demonstrated for some bacterial species and considered as conserved in Alphaproteobacteria. The σ(EcfG) factor activates its tar...

Electronic ISSN: 1471-2180

Topics: Biology

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An optimised protocol for isolation of RNA from small sections of laser-capture microdissected FFPE tissue amenable for next-generation sequencing (2018)

Parisa Amini, Julia Ettlin, Lennart Opitz, Elena Clementi, Alexandra Malbon and Enni Markkanen

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Formalin-fixed paraffin embedded (FFPE) tissue constitutes a vast treasury of samples for biomedical research. Thus far however, extraction of RNA from FFPE tissue has proved challenging due to chemical RNA–pr...

Electronic ISSN: 1471-2199

Topics: Biology

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A case of bilateral revision total knee arthroplasty using distal femoral allograft–prosthesis composite and femoral head allografting at the tibial site with a varus-valgus constrained prosthesis: ten-year follow up (2018)

Sung-Hyun Lee, Sung-Hyun Noh, Keun-Churl Chun, Joung-Kyue Han and Churl-Hong Chun

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: We report the successful use of allograft–prosthesis composite (APC) and structural femoral head allografting in the bilateral reconstruction of large femoral and tibial uncontained defects during revision tot...

Electronic ISSN: 1471-2474

Topics: Medicine

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The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study (2018)

Hyo Jin Kim, Eunjeong Kang, Yun Kyu Oh, Yeong Hoon Kim, Seung Hyeok Han, Tae Hyun Yoo, Dong-Wan Chae, Joongyub Lee, Curie Ahn and Kook-Hwan Oh

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-06

Description: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The prese...

Electronic ISSN: 1471-2369

Topics: Medicine

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