CaRLO — Cancer Research Library Online

1

Electronic Resource

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment (2007)

Wei, Ronnie R ; Al-Bassam, Jawdat ; Harrison, Stephen C

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 54-59

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Kinetochores are multicomponent assemblies that connect chromosomal centromeres to mitotic-spindle microtubules. The Ndc80 complex is an essential core element of kinetochores, conserved from yeast to humans. It is a rod-like assembly of four proteins— Ndc80p (HEC1 in humans), Nuf2p, Spc24p ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1186

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

2

Electronic Resource

CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response (2007)

Kim, Hongtae ; Huang, Jun ; Chen, Junjie

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 710-715

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain–containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1277

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

3

Electronic Resource

A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization (2007)

Buck, Teresa M ; Wagner, Justin ; Grund, Steven ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 762-769

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Aquaporin (AQP) folding in the endoplasmic reticulum is characterized by two distinct pathways of membrane insertion that arise from divergent residues within the second transmembrane segment. We now show that in AQP1 these residues (Asn49 and Lys51) interact with Asp185 at the C terminus of TM5 to ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1275

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

4

Electronic Resource

Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms (2007)

Wang, Hong-Wei ; Ramey, Vincent H ; Westermann, Stefan ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 721-726

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Dam1 kinetochore complex is essential for chromosome segregation in budding yeast. This ten-protein complex self-assembles around microtubules, forming ring-like structures that move with depolymerizing microtubule ends, a mechanism with implications for cellular function. Here we used EM-based ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1274

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

5

Electronic Resource

CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices (2007)

Baker, Jennifer M R ; Hudson, Rhea P ; Kanelis, Voula ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 738-745

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The regulatory (R) region of the cystic fibrosis transmembrane conductance regulator (CFTR) is intrinsically disordered and must be phosphorylated at multiple sites for full CFTR channel activity, with no one specific phosphorylation site required. In addition, nucleotide binding and hydrolysis at ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1278

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

6

Electronic Resource

A timely reminder (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 569-569

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A rather peculiar meeting took place at the Cold Spring Harbor Laboratory last month. For starters, many presentations began with an image of the Earth seen from space, half shrouded in nocturnal shadow (no, this wasn't a sci-fi convention). Another unusual feature was the curious mix of ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0707-569

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

7

Electronic Resource

An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane (2007)

Moraes, Trevor F ; Bains, Manjeet ; Hancock, Robert E W ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 85-87

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-Å resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1189

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

8

Electronic Resource

Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation (2007)

Nielsen, Anne Færch ; Leuschner, Philipp J F ; Martinez, Javier

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 572-573

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In the era of 'global biology', more and more unexpected interactions between macromolecular machines are being revealed. Guil and Caceres now add a new example to the ever-growing list. In their study on page 591 of this issue, hnRNP A1 is reported to take leave from its splicing duties to assume ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0707-572

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

9

Electronic Resource

An ESCRT for daughters (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 579-579

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] During normal cell division, cytokinesis begins as sister chromatids separate during mitotic anaphase. Constriction of the cell membrane by actin and myosin results in formation of the cleavage furrow, which further develops into a protein-rich membranous midbody structure. Abscission, the final ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0707-579

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

10

Electronic Resource

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 (2007)

Corsini, Lorenzo ; Bonna, Sophie ; Basquin, Jerome ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 620-629

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The U2AF-homology motif (UHM) mediates protein-protein interactions between factors involved in constitutive RNA splicing. Here we report that the splicing factor SPF45 regulates alternative splicing of the apoptosis regulatory gene FAS (also called CD95). The SPF45 UHM is necessary for this ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1260

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

11

Electronic Resource

Corrigendum: Shifting nanoscopic clock gears (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 568-568

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 362–363 (2007). In the version of this News and Views initially published, the following sentence was missing from the legend to Figure 1: “Figure scheme based on a design by S.R. ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0607-568b

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

12

Electronic Resource

Corrigendum: FtsK: A groovy helicase (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 568-568

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 13, 948–950 (2006). In the version of this News and Views initially published, the authors present a model to explain the low degree of positive DNA supercoiling generated during DNA translocation through the FtsK helicase. The authors' conclusion, that in a rotary ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0607-568c

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

13

Electronic Resource

Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement (2007)

Yang, Xiaofang ; Zaurin, Roser ; Beato, Miguel ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 540-547

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Yeast SWI/SNF is a multisubunit, 1.14-MDa ATP-dependent chromatin-remodeling enzyme required for transcription of a subset of inducible genes. Biochemical studies have demonstrated that SWI/SNF uses the energy from ATP hydrolysis to generate superhelical torsion, mobilize mononucleosomes, enhance ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1238

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

14

Electronic Resource

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing (2007)

Liu, Li ; Query, Charles C ; Konarska, Maria M

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 519-526

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The spliceosome is thought to undergo a conformational change between the two catalytic steps of precursor messenger RNA splicing, although the specific events in this transition are poorly understood. We previously proposed a two-state model of splicing in which the conformations required for the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1240

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

15

Electronic Resource

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK (2007)

Kobashigawa, Yoshihiro ; Sakai, Mieko ; Naito, Masato ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 503-510

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] CRKI (SH2-SH3) and CRKII (SH2-SH3-SH3) are splicing isoforms of the oncoprotein CRK that regulate transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. CRKI shows substantial transforming activity, whereas the activity of CRKII ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1241

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

16

Electronic Resource

Bluetongue virus VP4 is an RNA-capping assembly line (2007)

Sutton, Geoff ; Grimes, Jonathan M ; Stuart, David I ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 449-451

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Eukaryotic organisms cap the 5′ ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1225

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

17

Electronic Resource

Structure-based design of a pathway-specific nuclear import inhibitor (2007)

Cansizoglu, Ahmet E ; Lee, Brittany J ; Zhang, Zi Chao ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 452-454

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Kapβ2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx(2–5)PY motif. Here we show that Kapβ2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1229

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

18

Electronic Resource

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia (2007)

Cunningham, David ; Danley, Dennis E ; Geoghegan, Kieran F ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 413-419

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Proprotein convertase subtilisin kexin type 9 (PCSK9) lowers the abundance of surface low-density lipoprotein (LDL) receptor through an undefined mechanism. The structure of human PCSK9 shows the subtilisin-like catalytic site blocked by the prodomain in a noncovalent complex and inaccessible to ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1235

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

19

Electronic Resource

Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection (2007)

Nicolas, Estelle ; Yamada, Takatomi ; Cam, Hugh P ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 372-380

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Histone acetylation is important in regulating DNA accessibility. Multifunctional Sin3 proteins bind histone deacetylases (HDACs) to assemble silencing complexes that selectively target chromatin. We show that, in fission yeast, an essential HDAC, Clr6, exists in two distinct Sin3 core complexes. ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1239

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

20

Electronic Resource

Some more equal than others (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 251-251

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Publishers have varying policies as to when published articles become freely available to the public, but it seems that within any one publishing group the free access policy should be the same for all ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-251

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

21

Electronic Resource

Under DNA stress, gyrase makes the sign of the cross (2007)

Higgins, N Patrick

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 256-258

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Topoisomerases (Topo) are essential enzymes for moving chromosomes to specific locations during cell growth and division. They reversibly disrupt the phosphodiester backbone by forming a covalent phosphotyrosine bond with DNA. Type I Topo enzymes break one strand at a time and Type II Topo enzymes ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-256

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

22

Electronic Resource

A marked end (2007)

Chen, Xuemei

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 259-260

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Small RNAs of 20–30 nucleotides (nt) have emerged as universal regulators of gene expression and genome stability in fungi, plants and animals. The three currently known types of small RNAs — miRNAs, small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs) — are unified ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-259

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

23

Electronic Resource

La sets the tone for telomerase assembly (2007)

Teixeira, M Teresa ; Gilson, Eric

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 261-262

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Telomeres are nucleoprotein complexes that cap the ends of linear chromosomes and are essential for their function and stability. In many eukaryotic species, telomerase extends the guanosine-rich 3′ protruding ends of chromosomes in germline cells and regenerative tissues, as well as in tumor ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-261

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

24

Electronic Resource

Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 263-263

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Glutamine expansion under control Expansion of the CAG triplet coding for glutamine (Q) is a key characteristic of human spinocerebellar ataxia type 3 (SCA3), an inherited disorder leading to loss of muscle movement. Mechanisms underlying CAG repeat instability upon transmission to the next ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-263

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

25

Electronic Resource

Erratum: Histone merry-go-round (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 351-351

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nature Structural & Molecular Biology 14, 183 (2007). In the version of this Research Highlight originally published, we printed the incorrect name as corresponding author for the paper being highlighted. The corresponding author is Michel Strubin, not Rachel Imoberdorf. We apologize for this ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-351a

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

26

Electronic Resource

Erratum: Structural basis for the control of translation initiation during stress (2007)

Vila-Sanjurjo, Antón ; Schuwirth, Barbara-S ; Hau, Cathy W ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 351-351

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nature Structural & Molecular Biology 11, 1054–1059 (2004); published online 24 October 2004; corrected after print 20 March 2007 In the version of this article initially published, the PDB codes were incorrect. The correct codes for the protein Y bound ribosome are 1VOQ, 1VOS, 1VOV, ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0407-351b

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

27

Electronic Resource

Potent effect of target structure on microRNA function (2007)

Long, Dang ; Lee, Rosalind ; Williams, Peter ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 287-294

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] MicroRNAs (miRNAs) are small noncoding RNAs that repress protein synthesis by binding to target messenger RNAs. We investigated the effect of target secondary structure on the efficacy of repression by miRNAs. Using structures predicted by the Sfold program, we model the interaction between an ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1226

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

28

Electronic Resource

The 3′ termini of mouse Piwi-interacting RNAs are 2′-O-methylated (2007)

Ohara, Tomoya ; Sakaguchi, Yuriko ; Suzuki, Takeo ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 349-350

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1220

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

29

Electronic Resource

A riboswitch selective for the queuosine precursor preQ 1 contains an unusually small aptamer domain (2007)

Roth, Adam ; Winkler, Wade C ; Regulski, Elizabeth E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 308-317

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A previous bioinformatics-based search for riboswitches yielded several candidate motifs in eubacteria. One of these motifs commonly resides in the 5′ untranslated regions of genes involved in the biosynthesis of queuosine (Q), a hypermodified nucleoside occupying the anticodon wobble ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1224

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

30

Electronic Resource

Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 183-183

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Sensing energy levels AMP-activated protein kinase (AMPK) regulates cellular metabolism via phosphorylation of metabolic enzymes, transcriptional factors and coactivators. AMPK is a heterotrimeric αβγ complex that can monitor the energy status of the cell: it is activated when ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0307-183

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

31

Electronic Resource

Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins (2007)

Seward, David J ; Cubberley, Gabrielle ; Kim, Soojin ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 240-242

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Histone H3 Lys4 trimethylation (H3-K4me3) is a conserved mark of actively transcribed chromatin. Using a conditional mutant of the yeast H3-K4 methyltransferase, Set1p, we demonstrate rapid turnover of H3-K4me3 and H3-K4me2 in vivo and show this process requires Yjr119Cp, of the JARID1 family of ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1200

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

32

Electronic Resource

Structure of a VEGF–VEGF receptor complex determined by electron microscopy (2007)

Ruch, Claudia ; Skiniotis, Georgios ; Steinmetz, Michel O ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 249-250

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Receptor tyrosine kinases are activated upon ligand-induced dimerization. Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure. Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1202

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

33

Electronic Resource

RPA-like proteins mediate yeast telomere function (2007)

Gao, Hua ; Cervantes, Rachel B ; Mandell, Edward K ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 208-214

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Cdc13, Stn1 and Ten1 are essential yeast proteins that both protect chromosome termini from unregulated resection and regulate telomere length. Cdc13, which localizes to telomeres through high-affinity binding to telomeric single-stranded DNA, has been extensively characterized, whereas the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1205

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

34

Electronic Resource

Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 102-102

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Getting mixed signals During growth and development, cells must integrate multiple signaling cues. Piccolo and colleagues have now examined integration of two major signaling pathways, pursuing the idea that activity of the RTK/Ras pathway enhances responses to TGF-β pathway stimulation. The ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0207-102

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

35

Electronic Resource

Transcriptional noise and the fidelity of initiation by RNA polymerase II (2007)

Struhl, Kevin

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 103-105

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In the classic view of the transcriptome, RNA polymerase initiates transcription from specific sites that are designed to produce functional RNA products. However, biological processes do not work perfectly, and the fidelity of a biological process is defined by the frequency of an 'incorrect' ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0207-103

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

36

Electronic Resource

Keeping the right dosage (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 97-97

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Sex chromosomes present a gene expression dosage problem for the organisms that carry them: if the male is XY and the female XX, the female has a double dose of X chromosome genes. This has been overcome in very different ways in different organisms: whereas Drosophila melanogaster doubles gene ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0207-97

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

37

Electronic Resource

'Tis the season. . . (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1117-1117

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Despite the advent of antibiotics and vaccines, infectious diseases still account for around one-third of worldwide deaths, according to the World Health Organization. A molecular understanding of how pathogens cause disease is the object of intense research, and this issue of Nature Structural ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1207-1117

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

38

Electronic Resource

RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA (2007)

Jones, Hannah S ; Kawauchi, Junya ; Braglia, Priscilla ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 123-130

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] RNA polymerase (Pol) I–transcribed ribosomal genes of budding yeast exist as a tandem array (about 150 repeats) with transcription units separated by spacer sequences. Half of these rDNAs are inactivated by repressive chromatin structure, whereas the rest exist in an open conformation ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1199

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

39

Electronic Resource

Three-dimensional intricacies in protein-DNA recognition and transcriptional control (2007)

Harrison, Stephen C

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1118-1119

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Patterns of gene expression that determine the spatial organization of multicellular organisms depend on combinations of a remarkably modest collection of transcriptional regulators. For example, transcription factors in the Hox family of homeodomain-containing proteins control developmental ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1207-1118

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

40

Electronic Resource

A monkey wrench in the kinase machine (2007)

Leahy, Daniel J

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1120-1121

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The epidermal growth factor receptor (EGFR) mediates vital cell growth and differentiation events during normal animal development. Inappropriate EGFR activation is associated with several human cancers, however, and multiple regulatory mechanisms have evolved to restrict EGFR activity. One such ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1207-1120

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

41

Electronic Resource

Erratum: Histone chaperones: an escort network regulating histone traffic (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1231-1231

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 997–1007 (2007); published online 5 November 2007; corrected after print 5 November 2007 In the print version of this article, the reference to the Review by Shilatifard and co-workers is incorrect. On , it should be referred to as 'Bhaumik et al.68' and on , the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1207-1231

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

42

Electronic Resource

Structure and dynamics of a molten globular enzyme (2007)

Vamvaca, Katherina ; Vögeli, Beat ; Pervushin, Konstantin ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1202-1206

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Although protein dynamics has been recognized as a potentially important contributor to enzyme catalysis, structural disorder is generally considered to reduce catalytic efficiency. This widely held assumption has recently been challenged by the finding that an engineered chorismate mutase combines ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1325

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

43

Electronic Resource

NC2 mobilizes TBP on core promoter TATA boxes (2007)

Schluesche, Peter ; Stelzer, Gertraud ; Piaia, Elisa ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1196-1201

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The general transcription factors (GTFs) of eukaryotic RNA polymerase II, in a process facilitated by regulatory and accessory factors, target promoters through synergistic interactions with core elements. The specific binding of the TATA box–binding protein (TBP) to the TATA box has led to ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1328

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

44

Electronic Resource

A YY1–INO80 complex regulates genomic stability through homologous recombination–based repair (2007)

Wu, Su ; Shi, Yujiang ; Mulligan, Peter ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1165-1172

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] DNA damage repair is crucial for the maintenance of genome integrity and cancer suppression. We found that loss of the mouse transcription factor YY1 resulted in polyploidy and chromatid aberrations, which are signatures of defects in homologous recombination. Further biochemical analyses ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1332

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

45

Electronic Resource

A regulator of Dscam mutually exclusive splicing fidelity (2007)

Olson, Sara ; Blanchette, Marco ; Park, Jung ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1134-1140

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Down syndrome cell adhesion molecule (Dscam) gene has essential roles in neural wiring and pathogen recognition in Drosophila melanogaster. Dscam encodes 38,016 distinct isoforms via extensive alternative splicing. The 95 alternative exons in Dscam are organized into clusters that are spliced ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1339

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

46

Electronic Resource

Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex (2007)

Liang, Bo ; Xue, Song ; Terns, Rebecca M ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1189-1195

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The most complex RNA pseudouridylases are H/ACA ribonucleoprotein particles, which use a guide RNA for substrate capture and four proteins (Cbf5, Nop10, Gar1 and L7Ae/NHP2) for substrate modification. Here we report the three-dimensional structure of a catalytically deficient archaeal enzyme ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1336

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

47

Electronic Resource

L3MBTL1 recognition of mono- and dimethylated histones (2007)

Allali-Hassani, Abdellah ; Nady, Nataliya ; Qi, Chao ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1229-1230

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1340

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

48

Electronic Resource

Structure of the measles virus hemagglutinin (2007)

Colf, Leremy A ; Juo, Z Sean ; Garcia, K Christopher

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1227-1228

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Measles virus is a highly pathogenic virus that infects roughly 20 million people per year. We report here the crystal structure of the measles virus hemagglutinin, the surface glycoprotein responsible for the binding of measles virus to its host cell receptors. Although the protein lacks ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1342

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

49

Electronic Resource

Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS (2007)

Akitake, Bradley ; Anishkin, Andriy ; Liu, Naili ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1141-1149

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] We describe a mechanism connecting the adaptive behavior of the bacterial mechanosensitive channel MscS to the flexibility of the pore-lining helix TM3. Simulated expansion of the channel structure revealed straightening of a characteristic kink near Gly113 in the open state; return to the closed ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1341

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

50

Electronic Resource

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ (2007)

Raghuram, Srilatha ; Stayrook, Keith R ; Huang, Pengxiang ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1207-1213

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The nuclear receptors REV-ERBα (encoded by NR1D1) and REV-ERBβ (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here we show that heme is a physiological ligand of both receptors. Heme associates with the ligand-binding domains of the REV-ERB receptors ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1344

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

51

Electronic Resource

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid (2007)

Chimon, Sandra ; Shaibat, Medhat A ; Jones, Christopher R ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1157-1164

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Diffusible subfibrillar aggregates of amyloid proteins are potent neurotoxins and primary suspects in amyloid diseases including Alzheimer's disease. Despite widespread interest, the molecular structures of the amyloid intermediates and the conformational conversions in amyloid misfolding are ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1345

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

52

Electronic Resource

Chromatin structure depends on what's in the nucleosome's pocket (2007)

Caterino, Tamara L ; Hayes, Jeffrey J

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1056-1058

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Even though chromatin is arguably one of the most studied entities in the eukaryotic cell and is central to most nuclear processes that require access to genomic DNA, many mysteries regarding its structure remain. Indeed, much of what we know about this multifaceted hierarchical complex concerns ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1107-1056

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

53

Electronic Resource

Histone H3 Arg2 methylation provides alternative directions for COMPASS (2007)

Klose, Robert J ; Zhang, Yi

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1058-1060

add to mindlist on the mindlist

Details

ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The nucleosome forms the basic building block of chromatin and consists of 146 base pairs of DNA wrapped around a histone octamer. In addition to compacting DNA within the nucleus, histones also serve as a canvas for post-translational modifications that regulate and dictate chromatin function. In ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1107-1058

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

54

Electronic Resource

Funding crunch forces stem cell company to abandon therapies (2007)

Baker, Monya

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 951-952

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] With private investors apparently unwilling to back its efforts to bring a product to the clinic, Singapore's flagship stem cell company has ditched its cell-therapy programs in favor of other applications of stem cell technology, including licensing human embryonic stem (hES) cell lines created ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-951

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

55

Electronic Resource

News in brief (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 959-960

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Biomarker group grows The public-private biomedical partnership The Biomarkers Consortium has had a substantial rise in its contributing members since its formation in October 2006. The partnership between the National Institutes of Health (NIH) and private stakeholders now boasts more than 30 ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-959

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

56

Electronic Resource

The other side of staying out of a BIND (2007)

Wang, Kai

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 971-972

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] To the editor: A very unsympathetic correspondence in last September's issue by William Busa calls the disbanding of BIND, a database with public funding, a “happy consequence” so that the “rigors of the marketplace can impose upon its owners some deep regard for efficiency and ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-971b

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

57

Electronic Resource

NIH forges R&D partnerships in developing countries (2007)

Salicrup, Luis A.

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 976-977

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] To the editor: Persistent inequities in the availability of medicines for the poorest populations have catalyzed major public, non-profit and private sector players into action, leading to the establishment of a variety of initiatives that aim to strengthen local capacity for research and ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-976

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

58

Electronic Resource

Gene patents and genetic testing in the United States (2007)

Klein, Roger D

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 989-990

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Molecular genetic testing has increasingly been incorporated into clinical medicine, and this trend is likely to accelerate in the future. However, the introduction of genetic testing into medical practice is beginning to collide head on with patents that claim ownership of correlations between ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-989

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

59

Electronic Resource

Technology commercialization firms float in UK—but not elsewhere (2007)

Moran, Nuala

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 697-698

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Plotting routes to commercialize research is a preoccupation of universities worldwide. So it is a curiosity that one successful approach—of signing long-term deals with quoted technology commercialization companies—remains a uniquely British phenomenon. While the UK now has nine ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-697

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

60

Electronic Resource

Bad medicine (2007)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 707-709

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Counterfeit biologic drugs accounted for just 26 of the 2,083 cases involving fake pharmaceuticals logged during 2005 and 2006 by the Counterfeiting Incident System, a secure database managed by the Pharmaceutical Security Index (PSI). The not-for-profit industry body, located in Vienna, Virginia, ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-707

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

61

Electronic Resource

Counterpoint: MTAs are a practical necessity (2007)

Henderson, James

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 722-724

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Those of us working in technology transfer are well aware that academic investigators often find MTAs burdensome. Trust me, we know, and we recognize our duty to facilitate research by expediting material transfers. Yet, we also have a duty to protect all of our institution's interests. This ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-722

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

62

Electronic Resource

Recent patent applications in gene expression (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 742-742

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Recent patent applications in gene expression ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-742

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

63

Electronic Resource

How do shotgun proteomics algorithms identify proteins? (2007)

Marcotte, Edward M

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 755-757

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Shotgun proteomics is a remarkably powerful technology for identifying proteins, whether individually or in samples as complex as cell lysates. Take, for example, three notable recent applications—mapping the major protein complexes of yeast cells, systematically identifying proteins in ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-755

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

64

Electronic Resource

Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion (2007)

Wang, Kaihang ; Neumann, Heinz ; Peak-Chew, Sew Y ; [et al.]

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 770-777

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] In vivo incorporation of unnatural amino acids by amber codon suppression is limited by release factor-1–mediated peptide chain termination. Orthogonal ribosome-mRNA pairs function in parallel with, but independent of, natural ribosomes and mRNAs. Here we show that an evolved orthogonal ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt1314

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

65

Electronic Resource

US biodefense—shocking and awful (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 603-603

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Last month, the US Food and Drug Administration's (FDA) Vaccines and Related Biological Products Advisory Committee declared Acambis's modified vaccinia Ankara smallpox vaccine safe and efficacious. This makes somewhat baffling the US Department of Health and Human Services' (DHSS) decision to ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-603

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

66

Electronic Resource

FDA likely to further restrict erythropoietin use for cancer patients (2007)

Fox, Jeffrey L.

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 607-608

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Officials of the US Food and Drug Administration (FDA) forcefully presented their case against the use of erythropoiesis-stimulating agents (ESAs) among cancer patients during a heated session of the Oncologic Drugs Advisory Committee (ODAC) on May 10. ODAC members responded by solidly backing ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-607

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

67

Electronic Resource

What we know and don't know about Golden Rice (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 624-624

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Alexander J Stein, H P S Sachdev and Matin Qaim respond: Michael Krawinkel raises three issues in his comment to our economic analysis of Golden Rice. First, he questions the scientific basis of the assumptions that we have used in our impact assessment. Second, he claims that the development of ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-624a

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

68

Electronic Resource

A green light to expression in time and space (2007)

Mango, Susan E

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 645-646

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] In 1888, Heinrich Wilhelm Gottfried von Waldeyer-Hartz unwittingly began the 'omics revolution by coining the term 'chromosome' to describe colored (chromo) bodies (soma) that could be stained and visualized. Chromosome begat genome, which was followed by proteome, transcriptome, orfeome, ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-645

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

69

Electronic Resource

Addendum: Response to “Blame factory farming, not organic food” (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 687-687

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Nature Biotechnology responds Nature Biotechnology 25, 165–166 (2007); published online 7 February 2007; corrected after print 1 June 2007. The following information was not available when this correspondence response was initially published. At a California Senate hearing held on Tuesday, ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-687c

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

70

Electronic Resource

Engineering synthetic signaling proteins with ultrasensitive input/output control (2007)

Dueber, John E ; Mirsky, Ethan A ; Lim, Wendell A

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 660-662

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Many signaling proteins are built from simple, modular components, yet display highly complex signal-processing behavior. Here we explore how modular domains can be used to build an ultrasensitive switch—a nonlinear input/output function that is central to many complex biological behaviors. ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt1308

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

71

Electronic Resource

Recent patent applications in DNA synthesis (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 642-642

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Recent patent applications in DNA synthesis ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-642

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

72

Electronic Resource

Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 649-649

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Weigh station for biological particles Nanocantilevers determine the mass of small particles by measuring changes in the cantilever's resonance frequency caused by particle binding. For analytes in vacuum, resolution is on the order of zeptograms, but in aqueous solution it is much worse because ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-649

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

73

Electronic Resource

Corrigendum: Toll-free vaccines? (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 687-687

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Nature Biotechnology 25, 303–305 (2007); published online 7 March 2007; corrected after print 1 June 2007. In the version of this article initially published, reference 1 is incorrect. The correct reference is Gavin, A.L. et al. Science 314, 1936–1938 (2006). The incorrect ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0607-687b

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

74

Electronic Resource

Decoding global gene expression programs in liver cancer by noninvasive imaging (2007)

Segal, Eran ; Sirlin, Claude B ; Ooi, Clara ; [et al.]

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 675-680

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Paralleling the diversity of genetic and protein activities, pathologic human tissues also exhibit diverse radiographic features. Here we show that dynamic imaging traits in non-invasive computed tomography (CT) systematically correlate with the global gene expression programs of primary human ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt1306

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

75

Electronic Resource

"protein"〉RNase H -mediated retrovirus destruction in vivo triggered by oligodeoxynucleotides (2007)

Matzen, Kathrin ; Elzaouk, Lina ; Matskevich, Alexey A ; [et al.]

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 669-674

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] The HIV-1 RNase H can be prematurely activated by oligodeoxynucleotides targeting the highly conserved polypurine tract required for second strand DNA synthesis. This inhibits retroviral replication in cell-free HIV particles and newly infected cells. Here we extend these studies to an in vivo ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt1311

Permalink

		Signatur		Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

76

Electronic Resource

Will the current biofuels boom go bust? (2007)

Waltz, Emily

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 491-492

add to mindlist on the mindlist

Details

ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] A slew of state incentives are on the books for the first ...

Type of Medium: Electronic Resource