CaRLO — Cancer Research Library Online

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Women's Work : why is science still institutionally sexist? (2013)

London . : Nature Publishing Group

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Call number: M080:1

Pages: 134 p. : ill.

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A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription (2007)

Wei, Yufeng ; Liu, Shaohua ; Lausen, Jörn ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 653-661

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The eight twenty-one protein, ETO, is implicated in 12%–15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into ...

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URL: http://dx.doi.org/10.1038/nsmb1258

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The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins (2007)

Potts, Patrick Ryan ; Yu, Hongtao

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 581-590

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Most cancer cells activate telomerase to elongate telomeres and achieve unlimited replicative potential. Some cancer cells cannot activate telomerase and use telomere homologous recombination (HR) to elongate telomeres, a mechanism termed alternative lengthening of telomeres (ALT). A hallmark of ...

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URL: http://dx.doi.org/10.1038/nsmb1259

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Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs (2007)

Lee, Suzanne R ; Collins, Kathleen

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 604-610

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Many classes of small RNA (sRNA) involved in RNA silencing are generated by double-stranded RNA (dsRNA) processing. Although principles of sRNA biogenesis have emerged, newly identified classes of sRNAs have features that suggest additional biogenesis mechanisms. Tetrahymena thermophila expresses ...

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URL: http://dx.doi.org/10.1038/nsmb1262

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RS domain–splicing signal interactions in splicing of U12-type and U2-type introns (2007)

Shen, Haihong ; Green, Michael R

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 597-603

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Serine-arginine (SR) proteins are general metazoan splicing factors that contain an essential arginine/serine-rich (RS) domain. On typical U2-type introns, RS domains contact the branchpoint and 5′ splice site to promote base-pairing with U small nuclear RNAs (snRNAs). Here we analyze the ...

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URL: http://dx.doi.org/10.1038/nsmb1263

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Structure of the topoisomerase VI B subunit: implications for type II topoisomerase mechanism and evolution (2007)

Corbett, Kevin D ; Benedetti, Piero ; Berger, James M

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 611-619

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Type II topoisomerases help disentangle chromosomes to facilitate cell division. To advance understanding of the structure and dynamics of these essential enzymes, we have determined the crystal structure of an archaeal type IIB topoisomerase, topo VI, at 4.0-Å resolution. The 220-kDa ...

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URL: http://dx.doi.org/10.1038/nsmb1264

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New data, please (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 457-457

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The summer conference season is already in full swing. One of the great things about being a journal editor is the opportunity to go to different meetings (hopefully at beautiful locales), meet different people and learn about exciting new research. But this doesn't always happen — at least ...

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URL: http://dx.doi.org/10.1038/nsmb0607-457

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Role for BLM in replication-fork restart and suppression of origin firing after replicative stress (2007)

Davies, Sally L ; North, Phillip S ; Hickson, Ian D

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 677-679

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Mutations in BLM give rise to Bloom's syndrome, a genetic disorder associated with cancer predisposition and chromosomal instability. Using a dual-labeling system in isolated chromosome fibers, we show that the BLM protein is required for two aspects of the cellular response to replicative stress: ...

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URL: http://dx.doi.org/10.1038/nsmb1267

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Protein structure space is much more than the sum of its folds (2007)

Honig, Barry

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 458-458

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] To the Editor: A recent editorial in Nature Structural & Molecular Biology echoes questions being raised in the structural biology community and elsewhere as to whether the expense of The Protein Structure Initiative (PSI) is justified, given the current budget crunch at the US National ...

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URL: http://dx.doi.org/10.1038/nsmb0607-458

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Protein Structure Initiative: getting into gear (2007)

Matthews, Brian W

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 459-460

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Protein Structure Initiative (PSI; http://www.nigms.nih.gov/Initiatives/PSI), supported by the US National Institutes of Health (NIH), is now in the second year of its second five-year phase (PSI-2). The PSI represents about 3% of the National Institute of General Medical Sciences (NIGMS) ...

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URL: http://dx.doi.org/10.1038/nsmb0607-459

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Moving parts: how the adaptor protein CRK is regulated, and regulates (2007)

Cowburn, David

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 465-466

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] On page 503 of this issue, Kobashigawa et al. describe the solution structures of multiple forms of the adaptor protein CRK. Previously, the discovery of the oncogene of the avian sarcoma virus (a fusion of the crk gene with gag in a p37-encoding gene) and subsequent work led to the identification ...

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URL: http://dx.doi.org/10.1038/nsmb0607-465

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It takes more than two to tango: Dishevelled polymerization and Wnt signaling (2007)

Roberts, David M ; Slep, Kevin C ; Peifer, Mark

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 463-465

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A handful of signaling pathways are extraordinarily important in cell-fate choices in embryogenesis and adult homeostasis, and inappropriate activation of each pathway contributes to cancer. For example, Wnt signaling regulates cell-fate choices from early axis formation to stem-cell maintenance in ...

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URL: http://dx.doi.org/10.1038/nsmb0607-463

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RAD51, BRCA2 and DNA repair: a partial resolution (2007)

Lord, Christopher J ; Ashworth, Alan

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 461-462

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Inheritance of a single mutated allele of BRCA2 confers a strong predisposition to breast cancer and a number of other malignancies. This gene encodes a 3,418-residue protein that is likely to have multiple cellular functions and is important for the repair of double-strand breaks (DSBs) by ...

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URL: http://dx.doi.org/10.1038/nsmb0607-461

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Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 467-467

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Structuring selectivity Potassium channels show amazing discrimination, favoring K+ over other monovalent cations, such as Na+ and Li+. Although structural and functional studies have revealed much about the KcsA channel, including the residues physically involved in ion permeation and the ...

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URL: http://dx.doi.org/10.1038/nsmb0607-467

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Erratum: The structure of a polyQ–anti-polyQ complex reveals binding according to a linear lattice model (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 568-568

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 381–387 (2007); published online 22 April 2007; corrected after print 8 May 2007 In the version of this article initially published, the incorrect corresponding authors were listed. The corresponding author should be Pingwei Li ...

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URL: http://dx.doi.org/10.1038/nsmb0607-568a

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Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement (2007)

Yang, Xiaofang ; Zaurin, Roser ; Beato, Miguel ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 540-547

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Yeast SWI/SNF is a multisubunit, 1.14-MDa ATP-dependent chromatin-remodeling enzyme required for transcription of a subset of inducible genes. Biochemical studies have demonstrated that SWI/SNF uses the energy from ATP hydrolysis to generate superhelical torsion, mobilize mononucleosomes, enhance ...

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URL: http://dx.doi.org/10.1038/nsmb1238

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Corrigendum: FtsK: A groovy helicase (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 568-568

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 13, 948–950 (2006). In the version of this News and Views initially published, the authors present a model to explain the low degree of positive DNA supercoiling generated during DNA translocation through the FtsK helicase. The authors' conclusion, that in a rotary ...

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URL: http://dx.doi.org/10.1038/nsmb0607-568c

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Corrigendum: Shifting nanoscopic clock gears (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 568-568

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 362–363 (2007). In the version of this News and Views initially published, the following sentence was missing from the legend to Figure 1: “Figure scheme based on a design by S.R. ...

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URL: http://dx.doi.org/10.1038/nsmb0607-568b

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Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing (2007)

Liu, Li ; Query, Charles C ; Konarska, Maria M

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 519-526

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The spliceosome is thought to undergo a conformational change between the two catalytic steps of precursor messenger RNA splicing, although the specific events in this transition are poorly understood. We previously proposed a two-state model of splicing in which the conformations required for the ...

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URL: http://dx.doi.org/10.1038/nsmb1240

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Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 (2007)

Esashi, Fumiko ; Galkin, Vitold E ; Yu, Xiong ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 468-474

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The human breast cancer susceptibility gene BRCA2 is required for the regulation of RAD51-mediated homologous recombinational repair. BRCA2 interacts with RAD51 monomers, as well as nucleoprotein filaments, primarily though the conserved BRC motifs. The unrelated C-terminal region of BRCA2 also ...

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URL: http://dx.doi.org/10.1038/nsmb1245

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Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats (2007)

Davies, Owen Richard ; Pellegrini, Luca

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 475-483

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] BRCA2 has an essential function in DNA repair by homologous recombination, interacting with RAD51 via short motifs in the middle and at the C terminus of BRCA2. Here, we report that a conserved 36-residue sequence of human BRCA2 encoded by exon 27 (BRCA2Exon27) interacts with RAD51 through the ...

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URL: http://dx.doi.org/10.1038/nsmb1251

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Corrigendum: Structural basis for autoinhibition of Notch (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 455-455

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In the version of this article initially published, three references were missing from the reference list. The corrected reference list is shown below, and references have been renumbered accordingly. The error has been corrected in the HTML and PDF versions of the article. ...

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URL: http://dx.doi.org/10.1038/nsmb0507-455

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Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility (2007)

Xia, Mingxuan ; Land, Hartmut

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 215-223

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Many features of the cancer cell phenotype emerge as a result of cooperation between multiple oncogenic mutations. Here we show that activated RasV12 and loss of p53 function can cooperate to promote cell motility, a feature closely associated with cancer progression to malignancy. Our analysis ...

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URL: http://dx.doi.org/10.1038/nsmb1208

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene (2007)

Karni, Rotem ; de Stanchina, Elisa ; Lowe, Scott W ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 185-193

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Alternative splicing modulates the expression of many oncogene and tumor-suppressor isoforms. We have tested whether some alternative splicing factors are involved in cancer. We found that the splicing factor SF2/ASF is upregulated in various human tumors, in part due to amplification of its gene, ...

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URL: http://dx.doi.org/10.1038/nsmb1209

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Factor B structure provides insights into activation of the central protease of the complement system (2007)

Milder, Fin J ; Gomes, Lucio ; Schouten, Arie ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 224-228

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Factor B is the central protease of the complement system of immune defense. Here, we present the crystal structure of human factor B at 2.3-Å resolution, which reveals how the five-domain proenzyme is kept securely inactive. The canonical activation helix of the Von Willebrand factor A (VWA) ...

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URL: http://dx.doi.org/10.1038/nsmb1210

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Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast (2007)

Buker, Shane M ; Iida, Tetsushi ; Bühler, Marc ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 200-207

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The RNA-induced transcriptional silencing (RITS) complex, containing Ago1, Chp1, Tas3 and centromeric small interfering RNAs (siRNAs), is required for heterochromatic gene silencing at centromeres. Here, we identify a second fission yeast Argonaute complex (Argonaute siRNA chaperone, ARC), which ...

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URL: http://dx.doi.org/10.1038/nsmb1211

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Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit (2007)

Tarendeau, Franck ; Boudet, Julien ; Guilligay, Delphine ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 229-233

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The trimeric influenza virus polymerase, comprising subunits PA, PB1 and PB2, is responsible for transcription and replication of the segmented viral RNA genome. Using a novel library-based screening technique called expression of soluble proteins by random incremental truncation (ESPRIT), we ...

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URL: http://dx.doi.org/10.1038/nsmb1212

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Beyond the bench (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 89-89

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Joshua Lederberg's latest honor, the Presidential Medal of Freedom Award, recognized not only his many scientific accomplishments but those that benefited society as ...

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URL: http://dx.doi.org/10.1038/nsmb0207-89

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The cellular world according to Hsp90 (2007)

Richter, Klaus ; Hendershot, Linda M ; Freeman, Brian C

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 90-94

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Hsp90 molecular chaperone is ubiquitously expressed in all organisms and cell lineages; in addition, organelle-specific orthologs have been identified in a number of higher eukaryotes. Hsp90 has a role in nearly every cellular function that has been studied, and it is becoming increasingly ...

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URL: http://dx.doi.org/10.1038/nsmb0207-90

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Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease? (2007)

Hamilton, James A ; Deckelbaum, Richard J

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 95-97

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] With the well-documented successes of statins in lowering the concentration of 'bad' cholesterol (found mainly in low-density lipoprotein, or LDL) in human plasma and in diminishing cardiovascular disease (CVD), there is increasing effort to develop drugs to raise 'good' cholesterol (in HDL). This ...

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URL: http://dx.doi.org/10.1038/nsmb0207-95

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A topological mechanism for TRF2-enhanced strand invasion (2007)

Amiard, Simon ; Doudeau, Michel ; Pinte, Sébastien ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 147-154

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Telomeres can fold into t-loops that may result from the invasion of the 3′ overhang into duplex DNA. Their formation is facilitated in vitro by the telomeric protein TRF2, but very little is known regarding the mechanisms involved. Here we reveal that TRF2 generates positive supercoiling and ...

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URL: http://dx.doi.org/10.1038/nsmb1192

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Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC (2007)

Wang, Limin ; Zhao, Yiwei ; Li, Zhong ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 169-171

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] 'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-Å resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA ...

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URL: http://dx.doi.org/10.1038/nsmb1193

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A general amphipathic α-helical motif for sensing membrane curvature (2007)

Drin, Guillaume ; Casella, Jean-François ; Gautier, Romain ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 138-146

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Golgi-associated protein ArfGAP1 has an unusual membrane-adsorbing amphipathic α-helix: its polar face is weakly charged, containing mainly serine and threonine residues. We show that this feature explains the specificity of ArfGAP1 for curved versus flat lipid membranes. We built an ...

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URL: http://dx.doi.org/10.1038/nsmb1194

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The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a (2007)

Reese, Michael L ; Dakoji, Srikanth ; Bredt, David S ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 155-163

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The postsynaptic density protein PSD-95 and related membrane-associated guanylate kinases are scaffolding proteins, whose modular interaction motifs organize protein complexes at cell junctions. The signature guanylate kinase domain (GK) contains elements of the protein's GMP-binding site but does ...

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URL: http://dx.doi.org/10.1038/nsmb1195

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Structural analysis of a prototypical ATPase from the type III secretion system (2007)

Zarivach, Raz ; Vuckovic, Marija ; Deng, Wanyin ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 131-137

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The type III secretion system (T3SS) ATPase is the conserved and essential inner-membrane component involved in the initial stages of selective secretion of specialized T3SS virulence effector proteins from the bacterial cytoplasm through to the infected host cell, a process crucial to subsequent ...

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Three-dimensional intricacies in protein-DNA recognition and transcriptional control (2007)

Harrison, Stephen C

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1118-1119

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Patterns of gene expression that determine the spatial organization of multicellular organisms depend on combinations of a remarkably modest collection of transcriptional regulators. For example, transcription factors in the Hox family of homeodomain-containing proteins control developmental ...

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A monkey wrench in the kinase machine (2007)

Leahy, Daniel J

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1120-1121

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The epidermal growth factor receptor (EGFR) mediates vital cell growth and differentiation events during normal animal development. Inappropriate EGFR activation is associated with several human cancers, however, and multiple regulatory mechanisms have evolved to restrict EGFR activity. One such ...

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Merging the RNA and DNA worlds (2007)

Artsimovitch, Irina ; Vassylyev, Dmitry G

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1122-1123

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In extant cellular organisms, protein-based DNA-dependent RNA polymerases (RNAPs) transcribe DNA genomes in a highly regulated fashion. In the ancient “RNA world”, however, the RNA-based replicase is proposed to have replicated itself and the rest of the RNA genome. No naturally ...

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TIRF(ing) reveals Msh2-Msh6 surfing on DNA (2007)

Hingorani, Manju M

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1124-1125

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The idea that mismatch repair (MMR) could increase the fidelity of DNA replication was proposed three decades ago by Meselson and colleagues and validated by findings that MMR is essential for maintaining genomic integrity in organisms from bacteria to mammals. MMR proteins detect postsynthetic ...

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Research Highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1126-1126

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A life or death situation The unfolded protein response (UPR) is triggered by the detrimental accumulation of unfolded proteins in the endoplasmic reticulum. UPR activates cytoprotective pathways that reduce translation and induce chaperone expression to help rescue protein folding, but it also ...

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Erratum: Histone chaperones: an escort network regulating histone traffic (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1231-1231

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 997–1007 (2007); published online 5 November 2007; corrected after print 5 November 2007 In the print version of this article, the reference to the Review by Shilatifard and co-workers is incorrect. On , it should be referred to as 'Bhaumik et al.68' and on , the ...

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Mechanism of transcriptional stalling at cisplatin-damaged DNA (2007)

Damsma, Gerke E ; Alt, Aaron ; Brueckner, Florian ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1127-1133

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The anticancer drug cisplatin forms 1,2-d(GpG) DNA intrastrand cross-links (cisplatin lesions) that stall RNA polymerase II (Pol II) and trigger transcription-coupled DNA repair. Here we present a structure-function analysis of Pol II stalling at a cisplatin lesion in the DNA template. Pol II ...

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p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation (2007)

Rampalli, Shravanti ; Li, LiFang ; Mak, Esther ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1150-1156

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Cell-specific patterns of gene expression are established through the antagonistic functions of trithorax group (TrxG) and Polycomb group (PcG) proteins. Several muscle-specific genes have previously been shown to be epigenetically marked for repression by PcG proteins in muscle progenitor cells. ...

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Structure of phage P22 cell envelope–penetrating needle (2007)

Olia, Adam S ; Casjens, Sherwood ; Cingolani, Gino

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1221-1226

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Bacteriophage P22 infects Salmonella enterica by injecting its genetic material through the cell envelope. During infection, a specialized tail needle, gp26, is injected into the host, likely piercing a hole in the host cell envelope. The 2.1-Å crystal structure of gp26 reveals a 240-Å ...

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PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs (2007)

Diem, Michael D ; Chan, Chia C ; Younis, Ihab ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1173-1179

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction complex (EJC) probably mediates this enhancement; however, the specific link between the EJC and the translation machinery has not been ...

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A YY1–INO80 complex regulates genomic stability through homologous recombination–based repair (2007)

Wu, Su ; Shi, Yujiang ; Mulligan, Peter ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1165-1172

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] DNA damage repair is crucial for the maintenance of genome integrity and cancer suppression. We found that loss of the mouse transcription factor YY1 resulted in polyploidy and chromatid aberrations, which are signatures of defects in homologous recombination. Further biochemical analyses ...

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Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites (2007)

Kleijnen, Maurits F ; Roelofs, Jeroen ; Park, Soyeon ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1180-1188

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The 26S proteasome holoenzyme is formed by the association of a 20S core particle (CP) with a 19S regulatory particle (RP). The CP-RP interaction is labile and subject to regulation in vivo, but the factors controlling this association are poorly understood. Here we describe an in vitro proteasome ...

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Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex (2007)

Liang, Bo ; Xue, Song ; Terns, Rebecca M ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1189-1195

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The most complex RNA pseudouridylases are H/ACA ribonucleoprotein particles, which use a guide RNA for substrate capture and four proteins (Cbf5, Nop10, Gar1 and L7Ae/NHP2) for substrate modification. Here we report the three-dimensional structure of a catalytically deficient archaeal enzyme ...

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A regulator of Dscam mutually exclusive splicing fidelity (2007)

Olson, Sara ; Blanchette, Marco ; Park, Jung ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1134-1140

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Down syndrome cell adhesion molecule (Dscam) gene has essential roles in neural wiring and pathogen recognition in Drosophila melanogaster. Dscam encodes 38,016 distinct isoforms via extensive alternative splicing. The 95 alternative exons in Dscam are organized into clusters that are spliced ...

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L3MBTL1 recognition of mono- and dimethylated histones (2007)

Allali-Hassani, Abdellah ; Nady, Nataliya ; Qi, Chao ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1229-1230

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the ...

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Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS (2007)

Akitake, Bradley ; Anishkin, Andriy ; Liu, Naili ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1141-1149

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] We describe a mechanism connecting the adaptive behavior of the bacterial mechanosensitive channel MscS to the flexibility of the pore-lining helix TM3. Simulated expansion of the channel structure revealed straightening of a characteristic kink near Gly113 in the open state; return to the closed ...

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Molecular driving forces determining potassium channel slow inactivation (2007)

Cordero-Morales, Julio F ; Jogini, Vishwanath ; Lewis, Anthony ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1062-1069

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] K+ channels undergo a time-dependent slow inactivation process that plays a key role in modulating cellular excitability. Here we show that in the prokaryotic proton-gated K+ channel KcsA, the number and strength of hydrogen bonds between residues in the selectivity filter and its adjacent pore ...

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Autonomous synchronization of the circadian KaiC phosphorylation rhythm (2007)

Ito, Hiroshi ; Kageyama, Hakuto ; Mutsuda, Michinori ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1084-1088

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The cyanobacterial circadian oscillator can be reconstituted in vitro by mixing three purified clock proteins, KaiA, KaiB and KaiC, with ATP. The KaiC phosphorylation rhythm persists for at least 10 days without damping. By mixing oscillatory samples that have different phases and analyzing the ...

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The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks (2007)

Hanada, Katsuhiro ; Budzowska, Magda ; Davies, Sally L ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1096-1104

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have been disrupted by DNA damage in the template. Much less is known about the identities of these enzymes ...

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Histone chaperones: an escort network regulating histone traffic (2007)

De Koning, Leanne ; Corpet, Armelle ; Haber, James E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 997-1007

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be accessed for processes such as transcription and repair. Histones, the chief protein component of chromatin, must be assembled, replaced or exchanged to preserve or change this organization according to ...

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Prion strains under the magnifying glass (2007)

Cobb, Nathan J ; Surewicz, Witold K

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 882-884

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Decades after their discovery, prions remain one of the most controversial and enigmatic pathogens. Defined as infectious proteins that are devoid of any transmissible nucleic acids, these agents are believed to self-replicate by a mechanism involving a conformational switch, in which the abnormal ...

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Structure-function relationship of CAP-Gly domains (2007)

Weisbrich, Anke ; Honnappa, Srinivas ; Jaussi, Rolf ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 959-967

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In all eukaryotes, CAP-Gly proteins control important cellular processes. The molecular mechanisms underlying the functions of CAP-Gly domains, however, are still poorly understood. Here we use the complex formed between the CAP-Gly domain of p150glued and the C-terminal zinc knuckle of CLIP170 as ...

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Corrigendum: F1–ATPase rotates by an asymmetric, sequential mechanism using all three catalytic subunits (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 984-984

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Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In the version of this article initially published, the proposed model for coupling the rotation and catalysis of the F1 β subunits to the concerted activity of their active sites shown in Figure 4 was incorrectly drawn. A corrected version is depicted here. The error has been corrected in ...

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Structural determinants of RNA recognition and cleavage by Dicer (2007)

MacRae, Ian J ; Zhou, Kaihong ; Doudna, Jennifer A

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 934-940

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A hallmark of RNA interference is the production of short double-stranded RNA (dsRNA) molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer enzymes uniquely generate RNA products of specific lengths by mechanisms that have not been fully elucidated. Here we ...

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Distinct domains of complexin I differentially regulate neurotransmitter release (2007)

Xue, Mingshan ; Reim, Kerstin ; Chen, Xiaocheng ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 949-958

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Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Complexins constitute a family of four synaptic high-affinity SNARE complex–binding proteins. They positively regulate a late, post-priming step in Ca2+-triggered synchronous neurotransmitter release, but the underlying molecular mechanisms are unclear. We show here that SNARE complex binding ...

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CLIP170 autoinhibition mimics intermolecular interactions with p150 Glued or EB1 (2007)

Plevin, Michael J ; Hayashi, Ikuko ; Ikura, Mitsuhiko

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 980-981

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Topics: Biology , Medicine

Notes: [Auszug] CLIP170 and p150Glued localize to the plus ends of growing microtubules. Using crystallography and NMR, we show that autoinhibitory interactions within CLIP170 use the same binding determinants as CLIP170's intermolecular interactions with p150Glued. These interactions have both similar and ...

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Myosin-V makes two brownian 90° rotations per 36-nm step (2007)

Komori, Yasunori ; Iwane, Atsuko H ; Yanagida, Toshio

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 968-973

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Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Myosin-V processively walks on actin filaments in a hand-over-hand fashion. The identical structures of the heads predict a symmetric hand-over-hand mechanism where regular, unidirectional rotation occurs during a 36-nm step. We investigated this by observing how fixed myosin-V rotates actin ...

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E2–BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages (2007)

Christensen, Devin E ; Brzovic, Peter S ; Klevit, Rachel E

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 941-948

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Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] An E3 ubiquitin ligase mediates the transfer of activated ubiquitin from an E2 ubiquitin-conjugating enzyme to its substrate lysine residues. Using a structure-based, yeast two-hybrid strategy, we discovered six previously unidentified interactions between the human heterodimeric RING E3 ...

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Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA (2007)

Matsuda, Daiki ; Hosoda, Nao ; Kim, Yoon Ki ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 974-979

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Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nonsense-mediated mRNA decay (NMD) generally eliminates messenger RNAs that prematurely terminate translation and occurs in all eukaryotes that have been studied, although with mechanistic variations. In mammals, NMD seems to be restricted to newly synthesized mRNA that is bound by the cap-binding ...

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The structure of bacterial ParM filaments (2007)

Orlova, Albina ; Garner, Ethan C ; Galkin, Vitold E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 921-926

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Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit ...

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Erratum: Critics pan timid European response to TeGenero disaster (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 1057-1057

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Nature Biotechnology 25, 485–486 (2007); published online 6 April 2007 In the version of this article originally published, the performance of the UK Medical and Healthcare Products Regulatory Agency (MHRA) is described in the sentence of the penultimate paragraph in the 2nd column on p. 486 ...

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URL: http://dx.doi.org/10.1038/nbt0907-1057a

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Bacterial glycosidases for the production of universal red blood cells (2007)

Liu, Qiyong P ; Yuan, Huaiping ; Bennett, Eric P ; [et al.]

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 454-464

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Enzymatic removal of blood group ABO antigens to develop universal red blood cells (RBCs) was a pioneering vision originally proposed more than 25 years ago. Although the feasibility of this approach was demonstrated in clinical trials for group B RBCs, a major obstacle in translating this ...

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Messing with home brews (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 262-262

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Political moves to expand FDA oversight to home brews are a bad ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0307-262a

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Incretin mimetics vie for slice of type 2 diabetes market (2007)

Shaffer, Catherine

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 263-263

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] This February, New York–based Pfizer announced the acquisition of BioRexis Pharmaceutical, a biotech company in King of Prussia, Pennsylvania, with a strong product pipeline in type 2 diabetes, including long-acting agonists of glucagon-like peptide 1 (GLP-1) receptor, a key target in ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0307-263

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Negotiating the RNAi patent thicket (2007)

Schmidt, Charlie

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 273-275

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Last December, Merck of Whitehouse Station, New Jersey paid $1.1 billion for a company whose stock just three years ago was trading at 23¢ per share. Then called Ribozymes, and based in Boulder, Colorado, Sirna Therapeutics climbed to biotech's upper echelons by shifting its focus ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0307-273

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Towards quantitative analysis of proteome dynamics (2007)

Kühner, Sebastian ; Gavin, Anne-Claude

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 298-300

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ISSN: 1546-1696

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