Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • B-CELL  (1)
  • CELL LUNG-CANCER  (1)
  • 1
    Keywords: SPECTRA ; CELLS ; carcinoma ; CELL ; Germany ; human ; COMMON ; DIAGNOSIS ; PROTEIN ; PROTEINS ; ACCURACY ; INFECTION ; prognosis ; tumour ; SUFFICIENT ; T-CELL ; ASSOCIATION ; ACID ; ACIDS ; antibodies ; antibody ; NUCLEIC-ACIDS ; virus ; IDENTIFICATION ; IN-SITU ; MALIGNANCIES ; HUMANS ; REQUIRES ; MUSCLE ; CARCINOMAS ; adenocarcinoma ; ADENOCARCINOMAS ; INDIVIDUALS ; T lymphocyte ; pathology ; EPSTEIN-BARR-VIRUS ; SMOOTH-MUSCLE TUMORS ; Epstein-Barr virus ; MALIGNANCY ; RE ; EBV INFECTION ; VIRAL-PROTEINS ; HODGKINS-LYMPHOMA ; EVENTS ; EBV ; LARGE-CELL LYMPHOMA ; B-CELL ; SPECTRUM ; ENGLAND ; viral ; gastric ; Epstein Barr virus ; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY ; GASTRIC-CARCINOMA ; GUIDE ; INFLAMMATORY PSEUDOTUMOR ; PLASMABLASTIC LYMPHOMA ; POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISORDERS ; PYOTHORAX-ASSOCIATED LYMPHOMA
    Abstract: Epstein-Barr virus (EBV) is a herpesvirus associated with approximately 1% of tumours worldwide. EBV is the epitome of B lymphotropic viruses, but the spectrum of tumours it is associated with extends to T lymphocyte and NK cell malignancies, various types of carcinomas and smooth muscle tumours. Ubiquitous EBV infection in humans implies that most individuals carry EBV-infected cells. Therefore, mere detection of the virus in individuals with a tumour is not sufficient for establishing a causal relationship between both events, but instead requires unequivocal detection of viral nucleic acids or viral proteins in the tumour cells. Recent controversies about EBV infection in several carcinomas mainly resulted from such technical issues. The gold standard remains in situ EBER detection, but detection of EBNA1 would be an interesting alternative. EBV detection can be helpful for diagnostic, prognostic and therapeutic purposes. The rate of EBV association with entities such as NK/T cell tumours of the nasal type is so high that absence of detection of the virus in such a lesion should cast doubt of the accuracy of the diagnosis. Similarly, diagnosis of EBV-associated follicular pseudo-tumour obviously requires detection of the virus. EBV-positive common gastric adenocarcinomas seem to have a better prognosis than their EBV-negative counterparts and identification of the virus in B cell lymphoproliferations in immunocompromised individuals will guide therapeutic options. In conclusion, EBV-associated tumours are common enough to be relevant for the pathologist in everyday practice, but there is a need to facilitate detection of the virus (eg EBNA1 antibody)
    Type of Publication: Journal article published
    PubMed ID: 17873116
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CELL LUNG-CANCER ; LOCALIZATION ; adenocarcinoma ; WNT ; GASTROINTESTINAL STROMAL TUMORS ; TUMORIGENESIS ; GROWTH-FACTOR-RECEPTOR ; GENE MUTATION ; CARCINOSARCOMA ; HISTOGENESIS
    Abstract: Abstract: Introduction Pulmonary blastoma (PB) is a rare malignant lung tumour with an immature mesenchymal and epithelial component resembling fetal lung. In order to define potential therapeutic targets in PB, the authors analysed the status and possible role of EGFR, HER2 and c-KIT in the pathogenesis of this tumour type, and the diagnostic value of beta-catenin mutation analysis in PB. Methods 5 PBs were analysed for EGFR, HER2, c-KIT, and beta-catenin expression, as well as for mutations in EGFR, c-KIT, k-ras and the beta-catenin gene (CTNNB1). Results EGFR expression was observed in all PBs. An EGFR mutation was found in one of the tumours. No overexpression of c-KIT or HER2 was seen. No mutations were found in k-ras or c-KIT. 3 of 5 PBs displayed CTNNB1 mutations. Nuclear translocation of beta-catenin was seen in 2 of these tumours. Conclusions Detection of EGFR expression and mutation in PB suggest EGFR inhibition as a potential therapeutic option in the treatment of advanced PB. Moreover, the data confirm a crucial role of CTNNB1 mutations in the pathogenesis of PB, and indicate that CTNNB1 gene sequencing may be a useful in distinguishing PB from other types of lung cancer.
    Type of Publication: Journal article published
    PubMed ID: 21292787
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...