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  • Engineering  (7,692)
  • Biochemistry  (1,903)
  • Rehabilitation
  • Strömungsmechanik
  • Wiley-Blackwell  (9,532)
  • Springer International Publishing  (74)
  • Sage Publications  (6)
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Years
  • 1
    Keywords: Life sciences ; Biochemistry ; Life sciences ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Electrospinning Technology for Filtering Membranes Fabrication -- Current Advances on Nanofiber Membranes for Water Purification Applications -- Electrospun Filters for Air Filtration: Comparison with Existing Air Filtration Technologies -- Electrospun Filters for Defense and Protective Applications -- Electrospun Filters for Heavy Metals Removal -- Electrospun Filters for Organic Pollutants Removal -- Electrospun Filters for Oil-water Separation -- Affinity Membranes for Cell Capture and Biological Substances -- Electrospun Nanofibre Filter Media – New Emergent Technologies and Market Perspectives -- Index
    Abstract: This book covers the state-of-the-art on electrospun materials for the use of filters for water remediation, ion-exchange membranes and affinity membranes for the capture of selected chemical and biochemical species, as well as filtering applications covering air treatment, defense and protective applications, and oil-water separation. The book also provides an overview of the landscape of marketed electrospun filters and of technical approaches for the large scale production of nanofibrous non-woven filter media. This is an ideal book for biomaterials and polymer researchers interested in the applications of filtering media by electrospinning. Covers the latest research on ion-exchange membranes and affinity membranes for capture of cells and biological substances Broadens reader understanding of antimicrobial electrospun filters and sieving filters for liquid microfiltration Reviews exhaustively the key recent research into electrospun filters for oil-water separation, heavy metals removal, and defense and protective applications
    Pages: V, 230 p. 92 illus., 62 illus. in color. : online resource.
    ISBN: 9783319781631
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  • 2
    Keywords: Life sciences ; Microbiology ; Biochemistry ; Microbial ecology ; Environmental engineering ; Biotechnology ; Life sciences ; Microbiology ; Applied Microbiology ; Environmental Engineering/Biotechnology ; Biochemistry, general ; Microbial ecology ; Springer eBooks
    Description / Table of Contents: Adaptation to Varying Substrate Concentrations and Mixtures -- Amphiphilic Lipids, Signaling Molecules and Quorum Sensing -- Bacterial Signal Transduction Processes Based on Acetylation -- Biochemistry of Methylation of DNA -- Biofilm Development at Interfaces between Hydrophobic Organic Compounds and Water -- Biofilm Stress Responses Associated to Aromatic Hydrocarbons -- Bioinformatic, Molecular and Genetic Tools for Exploring Genome-wide Responses to Hydrocarbons -- Causes and Biochemistry of DNA Damage by Alkylation -- Chemotaxis to Hydrocarbons -- Cis-Trans Isomerase of Unsaturated Fatty Acids: An Immediate Bacterial Adaptive Mechanism to Cope with Emerging Membrane Perturbation Caused by Toxic Hydrocarbons -- DNA Methylation in Eukaryotes: Regulation and Function -- DNA Methylation in Prokaryotes: Regulation and Function -- Extrusion Pumps for Hydrocarbons: An Efficient Evolutionary Strategy to Confer Resistance to Hydrocarbons -- Fatty Acids as Mediators of Intercellular Signalling -- Feast: Choking on Acetyl-CoA, the Glyoxylate Shunt, and Acetyl-CoA-Driven Metabolism -- Fungi as Transport Vectors for Contaminants and Contaminant-Degrading Bacteria -- Genetics of Sensing, Accessing, and Exploiting Hydrocarbons -- Genomic Response of Pseudomonas putida to Toluene -- Hydrophobic Modifications of Biomolecules: An Introduction -- Kinetics and Physiology at Vanishingly Small Substrate Concentrations -- Lipidation of Other Biomolecules and Functions -- Lipids as Signalling Molecules in Eukaryotes -- Matrix-Hydrophobic Compound Interactions -- Membrane Adaptations to Low Water Two-Phase Bioprocess Systems -- Membrane Composition and Modifications in Response to Aromatic Hydrocarbons in Gram Negative Bacteria -- Microbiology of Oil Fly Larvae -- Microorganism-Hydrophobic Compound Interactions -- Mutagenic Consequences of Alkylation -- Nitrogen Fixation and Hydrocarbon-Oxidizing Bacteria -- One-Component Systems that Regulate the Expression of Degradation Pathways for Aromatic Compounds -- Problems of Feast or Famine: An Introduction: -- Problems of Hydrophobicity/Bioavailability: An Introduction -- Problems of Solventogenicity, Solvent Tolerance: An Introduction -- Production and Roles of Biosurfactants and Bioemulsifiers in Accessing Hydrophobic Substrates -- Protein Alkylation -- Protein Lipidation in Eukaryotes: Biochemistry and Function -- Protein Lipidation in Prokaryotes: Biochemistry and Function -- Protein Methylation in Bacteria -- Sensing, Signaling and Uptake: An Introduction -- Strategies to Increase Bioavailability and Uptake of Hydrocarbons -- Substrate Transport -- Surface Properties and Cellular Energetics of Bacteria in Response to the Presence of Hydrocarbons -- The Family of Two-Component Systems that Regulate Hydrocarbon Degradation Pathways -- The Potential of Hydrocarbon Chemotaxis to Increase Bioavailability and Biodegradation Efficiency -- Toxicity of Hydrocarbons to Microorganisms -- Transcriptional Regulation of Hydrocarbon Efflux Pump Expression in Bacteria -- Ultrastructural Insights into Microbial Life at the Hydrocarbon:Aqueous Environment Interface -- Uptake and Assimilation of Hydrophobic Substrates by the Oleaginous Yeast Yarrowia lipolytica -- Water-Hydrophobic Compound Interactions with the Microbial Cell
    Abstract: This book assembles concisely written chapters by world-leaders in the field summarizing recent advances in understanding microbial responses to hydrocarbons. Subjects treated include mechanisms of sensing, hydrocarbon tolerance and degradation as well as an overview on hydrophobic modification of biomolecules. Other chapters are dedicated to issues related to the reduced bioavailability of hydrocarbons, which differentiates this class of compounds form many others, but which of central importance to understand the ecophysiological consequences. This book should be standard literature in any laboratory working in this area
    Pages: 80 illus., 55 illus. in color. eReference. : online resource.
    ISBN: 9783319505428
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  • 3
    Keywords: Medicine ; Human Physiology ; Rehabilitation ; Sports Medicine ; Biomedicine ; Human Physiology ; Sports Medicine ; Rehabilitation ; Springer eBooks
    Description / Table of Contents: Introduction -- Cycling -- Force, Velocity and Power in Cycling -- Pedalling Technique, Effectiveness and Coordination -- Influence of Gear Ratios -- Measurements on Cycle Ergometers -- Ballistic Movements of Lower and Upper Limbs: Jumping and Pushing.-Simple Method for Measuring Jump Height and Power during Rebound and Drop Jump -- Simple Method for Measuring Force, Velocity and Power during Jumping -- Optimal Force-Velocity Profile in Jumping: Measurement and Relationship with Performance -- Simple Method for Measuring Stiffness during Hopping -- Simple Method for Measuring Force, Velocity, Power and Force-Velocity profile of Upper Limbs -- Running -- Simple Method for Measuring Lower Limb Stiffness during Running -- Measuring the Energetic Cost of Sprint Running -- Simple Method for Measuring Force, Velocity, Power and Force-Velocity profile and Optimal Force-Velocity profile during Sprint Running -- Measurements on Sprint Instrumented Treadmills -- Effectiveness of Force Production during Sprint Running
    Abstract: This book presents an account of innovative methods and, for most of them, gives direct and practical insights into how practitioners can benefit from their use in their everyday practice. It also explains how to interpret the data measured, and the underlying neuromechanical and biomechanical factors related to sports performance. Written and edited by the same researchers who proposed and validated these methods, this book not only presents innovative methods for an efficient training and testing process (most of which are based on very simple technology and data processing methods), but also discusses the associated background information. Although it is a young scientific discipline, sport biomechanics has taken on an important role in routine sports training, medicine and rehabilitation. It allows both a better understanding of human locomotion and performance and better design of training and injury prevention. In those processes, the testing of athletes is crucial, and the quality and quantity of the variables analysed directly influences the efficiency of physicians’, coaches’, physiotherapists’ and other practitioners’ interventions
    Pages: VIII, 314 p. 110 illus. : online resource.
    ISBN: 9783319056333
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  • 4
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    Cham : Springer International Publishing
    Keywords: Medicine ; Medical Microbiology ; Molecular Biology ; Biochemistry ; Biomedicine ; Molecular Medicine ; Biochemistry, general ; Medical Microbiology ; Springer eBooks
    Description / Table of Contents: Part I: A guide of metabolism during host-pathogen interactions -- 1. Cellular metabolism at a glance -- 2. Interaction between nutrition and metabolism -- 3. Interplay between metabolic sensors and cell signaling -- 4.℗ Alterations on cellular redox states upon infection and implications for host cell homeostasis -- 5. Mitochondrial bioenergetics and dynamics during infection -- 6. Computational systems biology of metabolism in infection -- 7. Metabolomic-based methods in diagnosis and monitoring infection progression -- Part II: Microbial metabolic adaptation and pathogen rewiring of host cell metabolism during infection -- 8. Metabolic host response to intracellular infections -- 9. Protozoan parasites auxotrophies and metabolic dependencies -- 10. Viral manipulation of the host metabolic network -- 11.℗ Metabolic regulation of innate immunity to fungal infection -- 12. Metabolic crosstalk between host and parasitic pathogens -- 13. Microbiome and gut dysbiosis
    Abstract: This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen
    Pages: VIII, 476 p. 45 illus., 43 illus. in color. : online resource.
    ISBN: 9783319749327
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  • 5
    Keywords: Life sciences ; Renewable energy resources ; Microbiology ; Biochemistry ; Microbial ecology ; Renewable energy sources ; Alternate energy sources ; Green energy industries ; Life sciences ; Microbiology ; Renewable and Green Energy ; Applied Microbiology ; Biochemistry, general ; Microbial ecology ; Springer eBooks
    Description / Table of Contents: Part. I.Bioremedation -- 1. Phycoremediation: An eco-friendly approach to solve water pollution problems -- 2. Microbial conversion of waste and surplus materials into high-value added products: The case of biosurfactants -- 3. Oil biodegradation -- 4.Bacterial decolourization, degradation and detoxification of azo dyes: an ecofriendly approach -- 5.Biological significance of degradation of polyhydroxyalkanoates -- 6. Microbial Biofouling: A possible solution to treat harmful microorganisms in ship ballast water -- Part II. Bioenergy -- 7. Xylanase- from paper to fuel -- 8. Microbial Fuel Cell technology: Technical challenges and Economic fusibility -- 9. Biohydrogen production: Integrated approaches to improve the process efficiency -- 10. Valorization of olive mill by-products towards sustainable biofuels and bio-based products -- 11. Algal biotechnology: the potential future fuel and prospects -- Part III. Future Perspectives -- 12. New Generation DNA Sequencing (NGS): Mining for genes and the potential of extremophiles -- 13. Impact of Next Generation Sequencing technology in plant microbe interaction study -- 14. An overview of Next-Generation Sequencing (NGS) technologies to study the Molecular Diversity of Genome -- 15. Marine polyextremophiles and their biotechnological applications
    Abstract: This contributed volume sheds new light on waste management and the production of biofuels. The authors share insights into microbial applications to meet the challenges of environmental pollution and the ever-growing need for renewable energy. They also explain how healthy and balanced ecosystems can be created and maintained using strategies ranging from oil biodegration and detoxification of azo dyes to biofouling. In addition, the book illustrates how the metabolic abilities of microorganisms can be used in microbial fuel-cell technologies or for the production of biohydrogen. It inspires young researchers and experienced scientists in the field of microbiology to explore the application of green biotechnology for bioremediation and the production of energy, which will be one of the central topics for future generations
    Pages: XII, 331 p. 47 illus., 41 illus. in color. : online resource.
    ISBN: 9783319526669
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  • 6
    Keywords: Medicine ; Human Genetics ; Antibodies ; Genetic Engineering ; Biochemistry ; Cell Biology ; Biomedicine ; Antibodies ; Genetic Engineering ; Human Genetics ; Cell Biology ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Background -- High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire -- In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire -- Paired VH:VL Analysis of Naïve B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors -- Conclusions and Future Perspectives -- Appendices
    Abstract: This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease
    Pages: XXVIII, 87 p. 34 illus. : online resource.
    ISBN: 9783319585185
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  • 7
    Unknown
    Cham : Springer International Publishing
    Keywords: Life sciences ; Microbiology ; Biochemistry ; Microbial ecology ; Microbial genetics ; Microbial genomics ; Astrophysics ; Life sciences ; Microbial ecology ; Applied Microbiology ; Microbial Genetics and Genomics ; Biochemistry, general ; Astrophysics and Astroparticles ; Springer eBooks
    Description / Table of Contents: The Climate of Snow and Ice as Boundary Condition for Microbial Life -- Limits for Microbial Life at Subzero Temperatures -- Aeromicrobiology -- Microbial Life in Supraglacial Environments -- Microbiology of Subglacial Environments -- Viruses in Glacial Environments -- Microbial Life in the Deep Sea: Psychropiezophiles -- Microbial Life in Permafrost -- Cyanobacteria in Polar and Alpine Ecosystems -- Enzyme Catalysis in Psychrophiles -- Cryoprotectants and Ice-Binding Proteins -- The Role of Exopolysaccharides in Microbial Adaptation to Cold Habitats -- Molecular Structure of Lipopolysaccharides of Cold-Adapted Bacteria -- Polar Microalgae: Functional Genomics, Physiology and the Environment -- Genomics of Psychrophilic Bacteria and Archaea -- Metagenomic Analysis of Low Temperature Environments -- Proteomic Insights of Psychrophiles -- From Transcriptomes to Metatranscriptomes: Cold Adaptation and Active Metabolisms of Psychrophiles from Cold Environments -- Biotechnological Aspects of Cold-Active Enzymes -- Biotechnological Improvements of Cold-Adapted Enzymes: Commercialization via an Integrated Approach -- Heterologous Protein Expression in Pseudoalteromonas haloplanktis TAC125 -- Psychrophiles as a Source of Novel Antimicrobials -- Permafrost Bacteria in Biotechnology: Biomedical Applications -- Cold-Adapted Basidiomycetous Yeasts as a Source of Biochemicals -- Perspectives of Low-Temperature Biomass Production of Polar Microalgae and Biotechnology Expansion Into High Latitudes -- Nitrification at Low Temperature for Purification of Used Water -- Biodegradation of Petroleum Oil in Cold Marine Environments -- Bioremediation of Petroleum Hydrocarbon Spills in Cold Terrestrial Environments -- Rhizoremediation in Cold Climates
    Abstract: This completely updated and revised second edition presents the most recent developments and advances in the field of microbial life in the cold, as well as the latest insights into the psychrophilic lifestyle. It particularly focuses on the exploitation of psychrophiles as a source of cold-active enzymes and biopolymers, and their benefits in the fields of biomedicine and bioremediation. Written by leading international experts, the book is intended for microbiologists, ecologists, molecular biologists, biochemists, environmental scientists and biotechnologists in academia and industry
    Pages: XVIII, 685 p. 97 illus., 55 illus. in color. : online resource.
    Edition: 2nd ed. 2017.
    ISBN: 9783319570570
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  • 8
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Medical Microbiology ; Biochemistry ; Microbiology ; Microbial genetics ; Microbial genomics ; Life sciences ; Eukaryotic Microbiology ; Microbial Genetics and Genomics ; Medical Microbiology ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: 1. Genomics and Functional Genomics in Chlamydomonas Reinhardtii -- 2.℗ Nuclear Transformation Toolbox Development -- 3.℗ Mitochondrial Bioenergetics Pathways in Chlamydomonas -- 4.℗ Bioenergetic Pathways in the Chloroplast Photosynthetic Electron Transfer -- 5.℗ Chlamydomonas: Bioenergetic Pathways: Regulation of Photosynthesis -- 6.℗ Chlamydomonas: Anoxic Acclimation and Signaling -- 7.℗ Chlamydomonas: Regulation Towards Metal Deficiencies -- 8.℗ Calcium-dependent Signalling Processes in Chlamydomonas -- 9.℗ Chlamydomonas: The Eyespot
    Abstract: This Microbiology Monographs volume covers the current and most recent advances in genomics and genetics, biochemistry, physiology, and molecular biology of C. reinhardtii. Expert international scientists contribute with reviews on the genome, post-genomic techniques, the genetic toolbox development as well as new insights in regulation of photosynthesis and acclimation strategies towards environmental stresses and other structural and genetic aspects, including applicable aspects in biotechnology and biomedicine. Powerful new strategies in functional genomic and genetics combined with biochemical and physiological analyses revealed new insights into Chlamydomonas biology
    Pages: V, 281 p. 26 illus., 17 illus. in color. : online resource.
    ISBN: 9783319663654
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  • 9
    Keywords: Life sciences ; Pharmacology ; Endocrinology ; Biochemistry ; Life sciences ; Biochemistry, general ; Pharmacology/Toxicology ; Endocrinology ; Springer eBooks
    Description / Table of Contents: Chapter 1. The Definition and Prevalence of Obesity and Metabolic Syndrome -- Chapter 2. Circadian Rhythms in Diet-induced Obesity -- Chapter 3. Eating and Death: Chronic Over-eating -- Chapter 4. Obesity and Persistent Organic Pollutants and Related Health Problems -- Chapter 5. Protein Kinases in Obesity -- Chapter 6. Fat cell and Fatty Acid Turnover in Obesity -- Chapter 7. Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome -- Chapter 8. What is Lipotoxicity -- Chapter 9. The Pathogenesis of Obesity-associated Adipose Tissue Inflammation -- Chapter 10. Obesity and Microbiota -- Chapter 11. Endoplasmic Reticulum Stress and Obesity -- Chapter 12. Insulin Resistance, Obesity-Lipotoxicity -- Chapter 13. Hypoxia and Adipose Tissue Dysfunction in Obesity -- Chapter 14. Adipocyte-macrophage Cross-talk in Obesity -- Chapter 15. Endothelial Dysfunction in Obesity -- Chapter 16. Diet Induced Obesity and the Mechanism of Leptin Resistance -- Chapter 17. Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity -- Chapter 18. Adiponectin and Adiponectin-resistance in Obesity -- Chapter 19. Non-alcoholic Fatty Liver Disease -- Chapter 20. Lipotoxicity-related Hematologic Disorders in Obesity -- Chapter 21. Micro-RNA and Adipogenesis -- Chapter 22. The Interactions Between Kynurenine and Pteridine Pathways in Obesity -- Chapter 23: Eligibility and Success Criteria for Bariatric/metabolic Surgery -- Chapter 24: Does Bariatric Surgery Improve the Lipotoxicity-related Complications of Obesity -- Chapter 25: Obesity-associated Breast Cancer: Analysis of Risk Factors -- Chapter 26: Lipotoxicity and Olive Oil in Obesity
    Abstract: Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. €œÓbesity and Lipotoxicitý€ is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. ́€œLipotoxicity and Obesitý€ will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field
    Pages: VIII, 624 p. 47 illus., 35 illus. in color. : online resource.
    ISBN: 9783319483825
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  • 10
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    Cham : Springer International Publishing
    Keywords: Medicine ; Pharmacology ; Complementary medicine ; Biochemistry ; Biomedicine ; Pharmacology/Toxicology ; Animal Biochemistry ; Complementary & Alternative Medicine ; Springer eBooks
    Description / Table of Contents: Part I: Honey -- Part II: Propolis -- Part III: Royal Jelly -- Part IV: Bee Pollen -- Part V: Honey bee venom
    Abstract: This book presents an updated discussion of the chemical composition and biological properties of the main bee products. Specific attention is focused on the beneficial biological activities of bee products in human health. Honey, royal jelly, propolis, bee pollen and bee venom are used as nutriment and in traditional medicine. Their composition is rather variable and depends on the floral source and external factors, such as seasonal, environmental conditions and processing. Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed
    Pages: VI, 306 p. 37 illus., 18 illus. in color. : online resource.
    ISBN: 9783319596891
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  • 11
    Keywords: Engineering ; Biotechnology ; Proteins ; Regenerative Medicine ; Tissue Engineering ; Aerospace engineering ; Astronautics ; Engineering ; Aerospace Technology and Astronautics ; Biotechnology ; Crystallography and Scattering Methods ; Protein Science ; Regenerative Medicine/Tissue Engineering ; Springer eBooks
    Abstract: This book summarizes the early successes, drawbacks and accomplishments in cell biology and cell biotechnology achieved by the latest projects performed on the International Space Station ISS. It also depicts outcomes of experiments in tissue engineering, ℗ cancer research and drug design and reveals the chances that research in Space offers for medical application on Earth. This SpringerBriefs volume provides an overview on the latest international activities in Space℗ and gives an outlook on the℗ potential of biotechnological research in Space in future. This volume is written for℗ ℗ students and researchers in Biomedicine, Biotechnology and Pharmacology and may specifically be of interest to scientists with focus on protein sciences, crystallization, tissue engineering, drug design and cancer research
    Pages: XV, 109 p. 36 illus., 15 illus. in color. : online resource.
    ISBN: 9783319640549
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  • 12
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    Cham : Springer International Publishing
    Keywords: Medicine ; Human Physiology ; Pharmacology ; Biochemistry ; Biomedicine ; Pharmacology/Toxicology ; Biochemistry, general ; Human Physiology ; Springer eBooks
    Description / Table of Contents: Part I: 3’,5’-cCMP and 3’,5’-cUMP as second messengers: cCMP and cUMP across the tree of life: From cCMP and cUMP generators to cCMP- and cUMP-regulated cell functions -- cCMP and cUMP in apoptosis: Concepts and methods -- Mammalian nucleotidyl cyclases and their nucleotide binding sites -- The Pseudomonas aeruginosa exoenzyme Y: A promiscuous nucleotidyl cyclase edema factor and virulence determinant -- Cyclic nucleotide monophosphates in plants and plant signalling -- cAMP-dependent protein kinase and cGMP-dependent protein kinase as cyclic nucleotide effectors -- Regulation of HCN ion channels by non-canonical cyclic nucleotides -- Identification of cCMP and cUMP substrate proteins and cross-talk between cNMPs -- Inactivation of non-canonical cyclic nucleotides: Hydrolysis and transport -- Part II: 3’,5’-cIMP, 8-nitro-cGMP, 2’,3’-cNMPs and cyclic dinucleotides as signaling molecules: 3’,5’-cIMP as potential second messenger in the vascular wall -- The discovery of 2’,3’-cNMPs in mammalian systems: From rodents to humans -- 8-Nitro-cGMP: A novel protein-reactive cNMP and its emerging roles in autophagy -- Cyclic dinucleotides in the scope of the mammalian immune system -- Part III: Methods/Tools for cNMP research: Mass-spectrometric analysis of non-canonical cyclic nucleotides -- Medicinal chemistry of the noncanonical cyclic nucleotides cCMP and cUMP -- Holistic methods for the analysis of cNMP effects -- The chemistry of the non-canonical cyclic dinucleotide 2'3'-cGAMP and its analogs
    Abstract: The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects
    Pages: VIII, 387 p. 65 illus., 35 illus. in color. : online resource.
    ISBN: 9783319526737
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  • 13
    Keywords: Life sciences ; Biochemical engineering ; Biochemistry ; Plant Biochemistry ; Cell Biology ; Molecular ecology ; Life sciences ; Cell Biology ; Biochemical engineering ; Molecular ecology ; Animal Biochemistry ; Plant Biochemistry ; Springer eBooks
    Description / Table of Contents: Part I Biochemistry and Physiology -- Chapter 1 Evolutionary Origin of Euglena -- Chapter 2 The Mitochondrion of Euglena gracilis -- Chapter 3 C2 Metabolism in Euglena -- Chapter 4 Biochemistry and Physiology of Reactive Oxygen Species in Euglena. Chapter 5 Biochemistry and Physiology of Vitamins in Euglena -- Chapter 6 Biochemistry and Physiology of Heavy Metal Resistance and Accumulation in Euglena -- Part II Cell and Molecular Biology -- Chapter 7 Euglena gracilis Genomes and Transcriptome: Organelles, Nuclear Genome Assembly Strategies, Initial Features -- Chapter 8 Euglena transcript processing -- Chapter 9 Photo and Nutritional Regulation of Euglena Organelle Development -- Chapter 10 Protein targeting to Euglena chloroplasts -- Chapter 11 Photomovement in Euglena -- Chapter 12 Gravitaxis in Euglena -- Part III Biotechnology -- Chapter 13 Wax Ester Fermentation and Its Application for Biofuel Production -- Chapter 14 Large-scale Cultivation of Euglena
    Abstract: This much-needed book is the first definitive volume on Euglena in twenty-fire years, offering information on its atypical biochemistry, cell and molecular biology, and potential biotechnology applications. This volume gathers together contributions from well-known experts, who in many cases played major roles in elucidating the phenomenon discussed. Presented in three parts, the first section of this comprehensive book describes novel biochemical pathways which in some instances have an atypical subcellular localization. The second section details atypical cellular mechanisms of organelle protein import, organelle nuclear genome interdependence, gene regulation and expression that provides insights into the evolutionary origins of eukaryotic cells. The final section discusses how biotechnologists have capitalized on the novel cellular and biochemical features of Euglena to produce value added products. Euglena: Biochemistry, Cell and Molecular Biology will provide essential reading for cell and molecular biologists with interests in evolution, novel biochemical pathways, organelle biogenesis and algal biotechnology. Readers will come away from this volume with a full understanding of the complexities of the Euglena as well as new realizations regarding the diversity of cellular processes yet to be discovered
    Pages: XIII, 303 p. 66 illus., 45 illus. in color. : online resource.
    ISBN: 9783319549101
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  • 14
    Unknown
    Cham : Springer International Publishing
    Keywords: Life sciences ; Medical Microbiology ; Biochemistry ; Microbiology ; Microbial genetics ; Microbial genomics ; Life sciences ; Eukaryotic Microbiology ; Microbial Genetics and Genomics ; Medical Microbiology ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: 1.℗ Chlamydomonas: Photoreceptors : Cellular Functions and Impact on Physiology -- 2.℗ Chlamydomonas: Hydrogenase and Hydrogen Production -- 3.℗ Chlamydomonas Reinhardtii: Protein Glycosylation and Production of Biopharmaceuticals -- 4.℗ Chlamydomonas: Cilia and Ciliopathies -- 5.℗ Chlamydomonas: Intraflagellar Transport -- 6.℗ The sexual Developmental Program of Chlamydomonas Reinhardtii -- 7.℗ Thylakoid Ultrastructure: Visualizing the Photosynthetic Machinery -- 8.℗ Chlamydomonas: Triacylglycerol Accumulation
    Abstract: This Microbiology Monographs volume covers the current and most recent advances in genomics and genetics, biochemistry, physiology, and molecular biology of C. reinhardtii. Expert international scientists contribute with reviews on the genome, post-genomic techniques, the genetic toolbox development as well as new insights in regulation of photosynthesis and acclimation strategies towards environmental stresses and other structural and genetic aspects, including applicable aspects in biotechnology and biomedicine.℗ Advancement in Chlamydomonas biology allowed new understandings in biotechnological and biomedical related aspects
    Pages: V, 217 p. 1 illus. : online resource.
    ISBN: 9783319663609
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  • 15
    Keywords: Life sciences ; Molecular Biology ; Pharmacology ; Biotechnology ; Biochemistry ; Cell Biology ; Animal genetics ; Life sciences ; Animal Biochemistry ; Cell Biology ; Pharmacology/Toxicology ; Biotechnology ; Molecular Medicine ; Animal Genetics and Genomics ; Springer eBooks
    Description / Table of Contents: 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters -- Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria -- Discovery and Development of Novel Drugs -- Computer Aided Drug Discovery from Marine Compounds: Identification of the Three-dimensional Structural Features Responsible for Antimalarial Activity -- BlueGenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification -- New Target Sites for Treatment of Osteoporosis -- Biocalcite and Carbonic Acid Activators -- Electrospinning of Bioactive Wound Healing Nets -- Entotheonella Bacteria as Source of Sponge-derived Natural Products: Opportunities for Biotechnological Production
    Abstract: This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products’ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies
    Pages: XI, 314 p. 176 illus., 72 illus. in color. : online resource.
    ISBN: 9783319512846
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  • 16
    Keywords: Medicine ; Immunology ; Neurosciences ; Pharmacology ; Endocrinology ; Biochemistry ; Biomedicine ; Pharmacology/Toxicology ; Biochemistry, general ; Neurosciences ; Immunology ; Endocrinology ; Springer eBooks
    Description / Table of Contents: Part 1: New Analytical tools -- Histamine and histamine receptors: State of the art -- Mass-spectrometric methods for the detection of histamine and histamine metabolites -- Fluorescent ligands and radioligands for the analysis of histamine receptors -- Molecular analysis of histamine receptors: Structural analysis of the histamine H1-receptor -- Molecular modelling approaches for the analysis of histamine receptors -- Cellular analysis of histamine receptors: Histamine release from human mast cells and basophils -- Histamine H2-receptor in blood cells: A suitable target for the treatment of acute myeloid leukemia -- Histamine H1-receptor-regulated gene expression and drug action of antihistamines -- Histamine metabolism and transport: Analysis of the role of histamine and genetically engineered mice in a human disease model -- Histamine clearance through polyspecific transporters in the brain -- Histamine decarboxylase deficiency as a cause for Tourette syndrome -- Histamine food poisoning -- Integrative role of histamine in major organ systems: Pharmacological implications: Regulation of the cardiovascular system by histamine -- Regulation of eating behavior by histamine -- Role of the histamine H3-receptor in the CNS -- Role of the histamine H4-receptor in bronchial asthma -- The histamine H4-receptor in pruritic skin disease -- Histamine in allergy and antihistamines
    Abstract: This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors
    Pages: VIII, 363 p. 90 illus., 30 illus. in color. : online resource.
    ISBN: 9783319581941
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  • 17
    Unknown
    Cham : Springer International Publishing
    Keywords: Life sciences ; Biochemistry ; Proteins ; Life sciences ; Animal Biochemistry ; Protein Science ; Protein Structure ; Springer eBooks
    Description / Table of Contents: Arrestins: discovery of the family and functional role of conformational flexibility -- Overview of arrestin-mediated signaling with receptors and non-receptor binding partners -- Initial crystallographic studies of visual arrestin: insights and perspectives -- Structural basis for b-arrestins in GPCR trafficking -- Arrestin-3: the structural basis of lower receptor selectivity -- Phosphate sensor and construction of phosphorylation-independent arrestins -- Comprehensive analysis of the role of arrestin residues in receptor binding -- How arrestin recognizes and binds active GPCRs -- Localization of conformational dynamics of arrestins by HDX-MS -- GPCR footprint on arrestins and manipulation of receptor specificity -- The structure of the polar core mutant R175E and its functional implications -- Active conformations of arrestins: expected and unexpected changes -- The arrestin-receptor complex: exciting answers and new questions -- Scaffolding c-Jun N-terminal kinase cascades: mechanistic insights from the reconstituted arrestin-JNK cascades -- Arrestin-dependent ERK activation and its disruption -- The functional role of the conformational changes in arrestin upon activation -- Is signaling specificity encoded in arrestin conformation? -- Monofunctional elements of multi-functional arrestin proteins -- Arrestins in cell death
    Abstract: This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death. Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery. The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings. The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes
    Pages: IX, 304 p. 53 illus., 51 illus. in color. : online resource.
    ISBN: 9783319575537
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  • 18
    Keywords: Life sciences ; Biochemistry ; Applied Ecology ; Molecular ecology ; Vertebrates ; Life sciences ; Vertebrates ; Molecular ecology ; Animal Biochemistry ; Applied Ecology ; Springer eBooks
    Description / Table of Contents: Are Mammals Just Furry Bugs with Fewer Legs? Convergences in Mammalian and Insect Chemical Ecology -- Chemical Signals in Vertebrates 13: Where We Stand and What Might Be Next -- Assessing the Role of Olfactory Cues in the Early Life History of Coral Reef Fish: Current Methods and Future Directions -- A Small Exposé on Bovine Pheromones - with Special Reference to Modifications of the Reproductive Cycle -- Coding of Group Odor in the Subcaudal Gland Secretion of the European Badger Meles meles: Chemical Composition and Pouch Microbiota -- The Role of Bacteria in Chemical Signals of Elephant Musth: Proximate Causes and Biochemical Pathways -- Age-related Variation in the Scent Pouch Bacterial Communities of Striped Hyenas (Hyaena hyaena) -- Bacterial Communities Associated with Junco Preen Glands: Preliminary Ramifications for Chemical Signaling -- Age-Related Effects on Individual Discrimination among Meadow Voles, Microtus pennsylvanicus -- Putative Pheromone of the Indian Crestless Porcupine, Hystrix brachyuran -- Chemical Cues, Hibernation and Reproduction in Female Short-Beaked Echidnas (Tachyglossus aculeatus setosus): Implications for Sexual Conflict -- Chemical Analyses Reveal Family Specific Nest Odor Profiles in Zebra Finches (Taeniopygia guttata): A Pilot Study -- Exploring the Use of Olfactory Cues in Non-Social Context in Zebra Finches (Taeniopygia guttata) -- Variation in Urinary Amino Acids in the Mozambique Tilapia: A Potential Signal of Dominance or Individuality? -- A Low Phytoestrogen Diet Reduces the Proceptivity but not the Attractivity of Meadow Voles (Microtus pennsylvanicus) -- Chemical communication in Indian Blackbuck (Antelope cervicapra L) with Special Reference to Dominance -- Asian Elephant Reflections: Chirality Counts -- Detection of Fish and Newt Kairomones by Ovipositing Mosquitoes -- Evolutionary Aspects of the Use of Predator Odors in Antipredator Behaviors of Lumholtz’s Tree-kangaroos (Dendrolagus lumholtzi) -- Small Emissions with Major Consequences: Specialized Malodorous Defenses in Birds -- A Review of Chemical Defense in Poison Frogs (Dendrobatidae): Ecology, Pharmacokinetics and Autoresistance -- Semiochemicals in Anurans: Testing different Categories with one Poison Frog Species -- Chemical Communication in Archaic New Zealand Frogs -- Chemical Signals in Giant Panda Urine (Ailuropoda melanoleuca) -- Semiochemical Communication in Dogs in the Context of Reproductive Behavior -- Hormonal and Behavioral Responses to Odor Cues in Zoo-housed African Painted Dogs (Lycaon pictus) -- Responses to Domestic Cat Chemical Signals in the House Mouse are Modulated by Early Olfactory Experience -- Does Deconvolution Help to Disentangle the Complexities of Mammal Odors? -- Guidelines for Collecting and Extracting Avian Odors in a Remote Field: Case Study of a Subantarctic Seabird -- Pair-specific Scents in African Wild Dogs, Lycaon pictus, and an Example of a Potential Method to Identify Signals within Complex Mixtures -- Automated headspace solid-phase microextraction of urinary VOCs from eleven maned wolves (Chrysocyon brachyurus): a recursive workflow for GC-MS analysis -- Learning and Applications of Chemical Signals in Vertebrates for Human-Wildlife Conflict Mitigation -- An Experimental Test of the Effect of Diet on Preen Wax Composition in New Zealand Silvereyes (Zosterops lateralis)
    Abstract: The thirteenth volume of Chemical Signals in Vertebrates (CSiV) emanates from the first joint meeting of CSiV and the International Society of Chemical Ecology (ISCE), which was held at the University of Illinois Urbana-Champaign in June 2014. Chemicals involved in communication in both mammals and insects are by and large secondary metabolites—that is, they are generally not molecules involved in the primary physiological processes of life, such as respiration, digestion, excretion, and in the case of green plants, photosynthesis
    Pages: XXII, 536 p. 77 illus., 17 illus. in color. : online resource.
    ISBN: 9783319220260
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  • 19
    Unknown
    Cham : Springer International Publishing
    Keywords: Life sciences ; Biotechnology ; Biochemistry ; Plant Biochemistry ; Animal Physiology ; Biomaterials ; Life sciences ; Animal Biochemistry ; Biomaterials ; Biological and Medical Physics, Biophysics ; Biotechnology ; Animal Physiology ; Plant Biochemistry ; Springer eBooks
    Description / Table of Contents: Adhesive Bacterial Exopolysaccharides -- Adhesion and Adhesives of Fungi and Oomycetes -- Diatom adhesives: Molecular and Mechanical Properties -- Progress in the study of adhesion by marine invertebrate larvae -- The Adhesive Tape‐like Silk of Aquatic Caddisworms -- Interfacial phenomena in marine and freshwater mussel adhesion -- Barnacle Underwater Attachment -- The biochemistry and mechanics of gastropod adhesive gels -- Adhesive secretions in echinoderms: A review -- An adhesive secreted by Australian frogs of the genus Notaden -- Properties, Principles, and Parameters of the Gecko Adhesive System -- Adhesive secretions in harvestmen (Arachnida: Opiliones) -- Unraveling the Design Principles of Black Widow’s Gumfoot Glue -- High-strength Adhesive Exuded from the Adventitious Roots of English Ivy -- Biomimetic Adhesives and Coatings Based on Mussel Adhesive Proteins
    Abstract: This book reviews the structure of different biological adhesives and the mechanisms by which they achieve interfacial adhesion, cohesive strength, and fracture toughness. These adhesives include cements, strongly adherent fibrous holdfasts, tough and flexible adhesive gels, energy-dissipating adhesive tapes, nanoparticle-based adhesives, hierarchically structured nanoarray adhesives and a wide variety of viscous, sticky secretions. Biological adhesives are complex biomaterials that have evolved to meet a wide variety of functional demands, and which range from the micro- to the macro-scale. Some adhesives set rapidly, while others set over longer periods of time; others can readily detach and reattach to allow movement and to manipulate objects, while yet others have the ability to self-heal after sustaining damage. Recent technological advances have expanded our ability to characterize these materials. Analyzing the physical and molecular structure, processing, chemical interactions and mechanical properties of these adhesives has yielded novel insights, which this new edition discusses in detail. These insights are likely to inform and guide the biomimetic development of new, powerful adhesives with desirable properties that are unmatched by today’s synthetic adhesives. Given the breadth and depth of its coverage, the book offers an invaluable source of information for industrial and academic researchers alike
    Pages: VIII, 378 p. 95 illus., 49 illus. in color. : online resource.
    Edition: 2nd ed. 2016.
    ISBN: 9783319460826
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  • 20
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Drug Resistance ; Biochemistry ; Cell Membranes ; Biophysics ; Biological physics ; Life sciences ; Membrane Biology ; Biophysics and Biological Physics ; Biochemistry, general ; Drug Resistance ; Springer eBooks
    Description / Table of Contents: ABC Importers -- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters -- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects -- Biology of mitochondrial ABCs and their contribution to pathology -- ABC transporters and multidrug resistance in fungi and yeast -- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors -- Techniques for the purification of ABC transporters -- HDAC inhibitors and MDR ABC transporters -- The role of polymorphisms in P-glycoprotein (ABCB1) on function -- Interaction of ABC transporters with drugs -- ABC insights from CFTR
    Abstract: This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders
    Pages: XIV, 376 p. 50 illus., 6 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319234762
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  • 21
    Keywords: Life sciences ; Neurochemistry ; Reproductive Medicine ; Biochemistry ; Neurobiology ; Life sciences ; Animal Biochemistry ; Neurochemistry ; Neurobiology ; Reproductive Medicine ; Springer eBooks
    Description / Table of Contents: Ch.1. Introduction – Influence of pheromones -- Ch.2. Findings in the early days -- Ch.3. Identification of the pheromones (H.A.Soini & M.V.Novotny) -- Ch.4. New primer effects on sperm -- Ch.5. A new primer effect on neurogenesis -- Ch.6. Identification of pheromones -- Ch.7. Pheromones and hormones -- Ch.8. Another new primer effect on females -- Ch.9. Trans-generational influence of pheromone -- Ch.10. Future possibilities
    Abstract: This SpringerBrief provides a concise summary on the chemistry and function of murine pheromones in reproduction. It discusses mechanisms of action as well as the applicability of these mechanisms to humans. The image of pheromones is usually some invisible mysterious chemicals that make people attracted to the opposite sex.℗ However, pheromones have many functions and one that perhaps is not well known yet is that they affect the reproductive status of others. Maleś€™ pheromones stimulate femaleś€™ reproductive status and vice versa. This book will present studies on male mice which is rarely covered and will also discuss trans-generational influences of pheromones. The book addresses Professors, researchers and students working in animal neurochemistry, chemical signaling and reproductive medicine
    Pages: X, 92 p. 31 illus., 17 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319139333
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  • 22
    Keywords: Life sciences ; Pharmacology ; Nanochemistry ; Biochemistry ; Nanoscale science ; Nanoscience ; Nanostructures ; Nanotechnology ; Life sciences ; Biochemistry, general ; Pharmacology/Toxicology ; Nanochemistry ; Nanotechnology ; Nanoscale Science and Technology ; Springer eBooks
    Description / Table of Contents: Abbreviations and designations -- Introduction -- Part I. Preparation and characterization of metal nanoparticles in solutions -- Chapter 1. Methods of the nanoparticles preparation in solutions -- Chapter 2. Biochemical synthesis of metal nanoparticles -- Chapter 3. Development of the biochemical synthesis for practical -- applications -- Chapter 4. Preparation of metal nanoparticles in water solutions on the basis of biochemical synthesis -- Chapter 5. Materials modified with metal nanoparticles -- Part II. Biological effects of metal nanoparticles -- Chapter 6. The effect of metal nanoparticles on biological objects (analysis of the literature) -- Chapter 7. Antimicrobial activity of nanoparticles stabilized with synthetic surfactant -- Chapter 8. The effect of silver nanoparticles on some objects from the “Plants” and “Fungi” kingdoms -- Chapter 9. The effect of silver nanoparticles on cultured human cells -- Inferences from the results of our studies -- Conclusion -- References
    Abstract: This book offers a comprehensive overview of recent studies conducted on the biological effects of metal nanoparticles. It also provides a solid theoretical foundation and various metal nanoparticle synthesis methods. Part I reviews the main chemical methods used for synthesizing metal nanoparticles in a solution and describes original method of biochemical synthesis, as well as some special procedures developed specifically for studying the biological activity of nanoparticles. Part II analyzes current literature on the effects of metal nanoparticles observed in microorganisms and addresses the influence of silver nanoparticles obtained by biochemical synthesis on biological objects on various organization levels, namely on microorganisms, acellular slim mold, unicellular alga, plant seeds and mammalian cells. The last section explains the central problems common in studies on the biological effects of metal nanoparticles and outlines potential uses of this trend in bio-nanotechnologies. This book is aimed at specialists, professors and students aspiring to expand their knowledge about the biological activities of metal nanoparticles and nanoparticle-containing materials
    Pages: XVI, 292 p. 159 illus., 26 illus. in color. : online resource.
    ISBN: 9783319309064
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  • 23
    Keywords: Medicine ; Human Genetics ; Public Health ; Epidemiology ; Bioinformatics ; Biochemistry ; Biomedicine ; Human Genetics ; Epidemiology ; Biochemistry, general ; Computational Biology/Bioinformatics ; Public Health ; Springer eBooks
    Description / Table of Contents: Introduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US. - 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix
    Abstract: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation
    Pages: XIII, 344 p. 52 illus. : online resource.
    Edition: 2nd ed. 2017.
    ISBN: 9783319480787
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  • 24
    Keywords: Life sciences ; Biochemistry ; Life sciences ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Bioinorganic Chemistry of the Alkali Metal Ions -- Determination of Alkali Ions in Biological and Environmental Samples -- Solid State Structures of Alkali Metal Ion Complexes Formed by Low-Molecular-Weight Ligands of Biological Relevance -- Discriminating Properties of Alkali Metal Ions towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies -- Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution -- Sodium and Potassium Interactions with Nucleic Acids -- Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability -- Sodium and Potassium Ions in Proteins and Enzyme Catalysis -- Roles and Transport of Sodium and Potassium in Plants -- Potassium versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters -- Sodium as Coupling Cation in Respiratory Energy Conversion -- Sodium-Proton (Na+/H+) Antiporters: Properties and Roles in Health and Disease -- Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases -- Bioinspired Artificial Sodium and Potassium Ion Channels -- Lithium in Medicine: Mechanisms of Action -- Sodium and Potassium Relating to Parkinson's Disease and Traumatic Brain Injury
    Abstract: MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems
    Pages: XLI, 628 p. 194 illus., 114 illus. in color. : online resource.
    ISBN: 9783319217567
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  • 25
    Keywords: Medicine ; Human Genetics ; Human Physiology ; Molecular Biology ; Metabolic Diseases ; Biochemistry ; Cell Biology ; Biomedicine ; Human Physiology ; Human Genetics ; Metabolic Diseases ; Molecular Medicine ; Biochemistry, general ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Intrauterine Growth Retardation (IUGR) as a novel condition of Insulin-like growth factor-1 (IGF-1) deficiency -- CFTR: A new horizon in the pathomechanism and treatment of pancreatitis -- Signature and pathophysiology of non-canonical pores in voltage-dependent cation channels -- Cardiac response to oxidative stress induced by mitochondrial dysfunction
    Abstract: Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields
    Pages: V, 129 p. 17 illus., 15 illus. in color. : online resource.
    ISBN: 9783319314921
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  • 26
    Unknown
    Cham : Springer International Publishing
    Keywords: Medicine ; Human Genetics ; Human Physiology ; Immunology ; Pharmacology ; Biochemistry ; Biomedicine ; Pharmacology/Toxicology ; Immunology ; Biochemistry, general ; Human Physiology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Overview of the Immune Response -- Role of Cytokines -- Cytokine Receptors and Signaling -- Immunosuppressive Agents -- Monoclonal Antibodies as Therapeutic Agents -- Allergic Disease -- Tissue Transplantation -- Acquired Immune Deficiency Syndrome -- Regulatory T Cells and Disease State -- Gene Therapy
    Abstract: The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010. These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT. Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies – both binding and neutralizing – to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells. From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer
    Pages: XIX, 442 p. 71 illus. in color. : online resource.
    Edition: 2nd ed. 2016.
    ISBN: 9783319302737
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  • 27
    Keywords: Life sciences ; Biochemistry ; Bioinformatics ; Ecology ; Animal genetics ; Nature conservation ; Marine Sciences ; Freshwater ; Life sciences ; Ecology ; Animal Genetics and Genomics ; Marine & Freshwater Sciences ; Nature conservation ; Biochemistry, general ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: 1. DNA Barcoding in the Marine Habitat: An Overview -- 2. Measurement of a Barcode’s Accuracy in Identifying Species -- 3. DNA barcoding: a tool to assess and conserve marine biodiversity -- 4. Safety Assessment and authentication of seafood through DNA barcoding -- 5. Bioinformatics tools in Marine DNA Barcoding -- 6. Morphological and COI sequence based charactersation of Marine Polychaete Species from Great Nicobar Island, India -- 7. Revised Phylogeny of Extant Xiphosurans (Horseshoe Crabs) -- 8. DNA Barcoding in marine nematodes: successes and pitfalls -- 9. DNA barcoding of calanoid copepods from the gulf of california -- 10. DNA Barciding of Primitive Species - Nemertine from Sundarbans Marine Bio-Resourse -- 11. Future Perspectives of DNA Barcoding in Marine Zooplanktons and Invertebrates -- 12. Molecular Positioning of Living Fossils (Horseshoe Crab) Using DNA Barcoding Approach -- 13. Mitochondrial DNA diversity of Wild and Hatchery Reared Strains of Indian Lates calcarifer (Bloch) -- 14. Barcoding Antarctic fishes: species discrimination and contribution to elucidate ontogenetic changes in Nototheniidae -- 15. Barcoding of Indian marine fishes: For identification and conservation -- 16. DNA barcoding Identifies Brackish Water fishes from Nallavadu Lagoon, Puducherry, India -- 17. DNA Barcoding of Marine fish: Prospects and Challenges -- 18. DNA Barcoding in Phytoplankton and other algae in Marine Ecosystem: An Effective Tool for Biodiversity Assessment -- 19. A search for a single DNA barcode for seagrasses of the world
    Abstract: More than two third area of our planet is covered by oceans and assessment of marine biodiversity is a challenging task. With the increasing global population, there is a tendency to exploit marine recourses for food, energy and other requirements. This puts pressure on the fragile marine environment and necessitates sustainable conservation efforts. Marine species identification using traditional taxonomical methods are often burdened with taxonomic controversies. Here in this book we will discuss the comparatively new concept of DNA barcoding and its significance in marine perspective. This molecular technique can be useful in the assessment of cryptic species which is widespread in marine environment and linking the different life cycle stages to the adult which is difficult to accomplish in the marine ecosystem. Other advantages of DNA barcoding include authentication and safety assessment of seafood, wildlife forensics, conservation genetics and detection of invasive alien species (IAS). Global DNA barcoding efforts in the marine habitat include MarBOL, CeDAMar, CMarZ, SHARK-BOL, etc. DNA barcoding of different marine groups ranging from the microbes to mammals is to be revealed. In conjugation with newer and faster techniques like high throughput sequencing, DNA barcoding is serving as an effective modern tool in marine biodiversity assessment and conservation
    Pages: X, 330 p. 54 illus., 38 illus. in color. : online resource.
    ISBN: 9783319418407
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  • 28
    Keywords: Life sciences ; Molecular Biology ; Biochemical engineering ; Biochemistry ; Life sciences ; Biochemistry, general ; Biochemical engineering ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: 100 years of Enzyme Immobilization -- Basics of Enzyme Immobilization -- Enzyme Immobilization: An Important Link between Agriculture and Industries -- Implication of Enzyme Immobilization in Therapeutics as well as Diagnostics of Diseases -- Enzyme Immobilization: Solution Towards Various Environmental Issues
    Abstract: This book covers the latest developments in enzyme immobilization with its wide applications, such as for industry, agriculture, medicine, and the environment. Topics covered include basics of enzyme immobilization, its implication in therapeutics and disease diagnostics, and its significance in solving environmental problems. This is an ideal book for researchers, graduate and postgraduate students, as well as scientists in industry, agriculture and health sectors. This book is a complete summary of enzyme immobilization and also thoroughly covers all the latest research. This book covers: The last one-hundred years of innovative research done in enzyme immobilization Recent developments in immobilization techniques, such as types of matrices, immobilization methods, and linking agents, as well as enzyme immobilization without any matrices and its properties The physiological and industrial significance of enzymes from plants and the implementation of immobilized enzymes in the treatment of waste water and polluted air Biomedical and bioanalytical applications of immobilized enzymes
    Pages: X, 132 p. 14 illus., 10 illus. in color. : online resource.
    ISBN: 9783319414188
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  • 29
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Nutrition ; Diabetes ; Hepatology ; Metabolic Diseases ; Biochemistry ; Life sciences ; Biochemistry, general ; Metabolic Diseases ; Hepatology ; Diabetes ; Nutrition ; Springer eBooks
    Description / Table of Contents: Transcriptional Regulation of De Novo Lipogenesis in Liver -- The Molecular Basis of Hepatic De Novo Lipogenesis in Insulin Resistance -- Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin -- FoxO1: A Conductor of Insulin Signaling to Glucose and Lipid Metabolism -- Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease -- Role of the Endocannabinoid System in Hepatic Lipogenesis -- Role of Lipogenesis and Lipid Desaturases in Non-Alcoholic Fatty Liver Disease -- Lipid Droplet Proteins and Lipid Metabolism -- Influence of Gut Microbiota on Hepatic Lipogenesis and Disease Pathogenesis -- Hepatic Lipogenesis: Nutritional Control and Pathophysiological Relevance -- Metabolic Rhythm of Hepatic Lipogenesis: Regulation and Roles in Metabolism -- Monounsaturated Fatty Acid Mediated Liver-adipose Tissue Crosstalk and Metabolic Regulation -- Adipose Tissue DNL and Its Role in Metabolic Homeostasis -- The Lipogenic Effect of Insulin Revisited -- Index.℗
    Abstract: The liver is the largest solid vital organ in mammals that supports other organ in the body in some facet.℗ This book synthesizes all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role of the liver in metabolism. With the current epidemic of metabolic diseases, it is of immediate importance to understand the contribution of the liver in health and its role in the development of impaired metabolic regulation. This book covers the many studies that have unmasked important roles that proteins expressed in the liver play in the development of or protection from metabolic diseases. One of the major metabolic functions of the liver is to carry out de novo lipogenesis, which is the metabolic pathway that allows the conversion of excess carbohydrates into fatty acids. The process of de novo lipogenesis is covered in depth within this volume. ℗ The book is an important contribution to the vast literature and ongoing research on liver function
    Pages: XI, 305 p. 35 illus., 5 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319250656
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  • 30
    Keywords: Life sciences ; Biochemistry ; Microbial genetics ; Microbial genomics ; Mycology ; Life sciences ; Mycology ; Microbial Genetics and Genomics ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Molecular biology of asexual sporulation in filamentous fungi -- Insight into fungal secondary metabolism from ten years of LaeA research -- RNAi function and diversity in fungi -- Fungal molecular response to heavy metal stress -- Control of gene expression in phytopathogenic ascomycetes during early invasion of plant tissue -- Fungal MAP Kinase-mediated regulatory pathways -- Heterotrimeric G-proteins -- The cell wall polysaccharides of Aspergillus fumigatus -- Chitin synthesis and fungal cell morphogenesis -- Trehalose metabolism: enzymatic pathways and physiological functions -- Regulation of Fungal Nitrogen Metabolism -- Regulation of Sulfur Metabolism in Filamentous Fungi -- The Regulation of Carbon Metabolism in Filamentous Fungi -- Special aspects of fungal catabolic and anabolic pathways -- Genetic and metabolic aspects of primary and secondary metabolism of the Zygomycetes
    Abstract: This new edition provides a comprehensive look at the molecular genetics and biochemical basis of fungal biology, covering important model organisms such as Aspergilli while also integrating advances made with zygomycetes and basidiomycetes. This book groups a total of 15 chapters authored by expert scholars in their respective fields into four sections. Five chapters cover various aspects of gene expression regulation. These range from regulation in organismal interactions between parasitic fungi and their host plant, heavy metal stress and global control of natural product genes to conidiation and regulation through RNA interference. Two chapters are dedicated to signal transduction, highlighting MAP-kinase-dependent signaling and heterotrimeric G-proteins. Fungal carbohydrates are the subject of the third section, which addresses both polymeric cell wall carbohydrates and trehalose as an important, low molecular weight carbohydrate. The fourth section emphasizes the metabolism of major elements (carbon, nitrogen, sulfur) and critical cellular pathways for primary and secondary products
    Pages: XVIII, 397 p. 50 illus., 21 illus. in color. : online resource.
    Edition: 3rd ed. 2016.
    ISBN: 9783319277905
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  • 31
    Keywords: Life sciences ; Immunology ; Biochemistry ; Cell Biology ; Life sciences ; Cell Biology ; Immunology ; Animal Biochemistry ; Springer eBooks
    Description / Table of Contents: Autophagy (Autophagia) from 1860 to 1963 -- History of Autophagy after 1963 -- Signalling in Autophagy -- Autophagosome Formation -- Physiological Role of Autophagy and Implications in Disease -- Studying autophagy: List of useful antibodies produced via a community effort
    Abstract: This book provides an expert summary of autophagy, a relatively new but rapidly expanding field of biomedical science with important implications in health and disease. After a historical review ranging up to the identification of autophagy genes in mammals, the authors discuss the signaling pathways that regulate autophagy, the mechanism of autophagosome formation and the physiological roles of autophagy in development, ageing, neurodegeneration, immune function and cell differentiation. A comprehensive list of useful antibodies for studying autophagy compiled as a community effort is included at the end. The book is intended for newcomers to the field, as well as more experienced researchers looking for a condensed but comprehensive introduction to the physiological function and regulation of the autophagic pathway in mammalian organisms
    Pages: VI, 103 p. 15 illus., 12 illus. in color. : online resource.
    ISBN: 9783319331454
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  • 32
    Unknown
    Cham : Springer International Publishing
    Keywords: Life sciences ; Biochemistry ; Animal anatomy ; Animal Physiology ; Vertebrates ; Life sciences ; Animal Physiology ; Vertebrates ; Animal Anatomy / Morphology / Histology ; Animal Biochemistry ; Springer eBooks
    Description / Table of Contents: Introduction -- Renal Morphology -- Initial Process in Urine Formation -- Transport of Inorganic Ions by Renal Tubules -- Transport of Fluid by Renal Tubules -- Transport of Organic Substances by Renal Tubules -- Diluting and Concentrating Mechanism -- Integrative Summary of Renal Function
    Abstract: This second edition offers a comprehensive overview of the physiological functions of vertebrate kidneys from a comparative viewpoint, with particular emphasis on nonmammalian vertebrates. The topics covered include renal structure; glomerular ultrafiltration; tubular transport of inorganic ions, organic substances, and fluid; and urine dilution and concentration. Mammalian renal function is only considered for purposes of comparison with nonmammalian renal function and as a frame of reference for some of the discussions. The major findings on nonmammalian renal function and the important unanswered questions raised by those findings are described in detail. As such, the book provides comprehensive information on comparative renal function for biological scientists and advanced students of biology with some knowledge of physiology and a desire to know more about renal function in vertebrates, and for mammalian renal physiologists who wish to obtain a broader view of renal function
    Pages: X, 292 p. 17 illus., 1 illus. in color. : online resource.
    Edition: 2nd ed. 2016.
    ISBN: 9781493937349
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  • 33
    Keywords: Life sciences ; Biochemistry ; Plant Biochemistry ; Proteins ; Cell Biology ; Evolutionary Biology ; Life sciences ; Protein Science ; Evolutionary Biology ; Cell Biology ; Plant Biochemistry ; Animal Biochemistry ; Animal Systematics/Taxonomy/Biogeography ; Springer eBooks
    Description / Table of Contents: A review on the origin of the different codes for translation -- Evolution of ribosomes -- Origins and early evolution of ribosomes -- Evolution of ribosomes and ribosomal proteins -- Evolution of Class II aminoacyl synthetases from the antisense of the genes for Class I -- The translation process during the evolutionary transition from prokaryotes to eukaryotes -- Evolution of translational control: from archaea to eukarya -- Distribution of elongation family GTPases EF1A and EFL in basal alveolate lineages -- Evolution of mRNA structure; the eukaryotic mRNA 5´- and 3´- untranslated regions and their role in translational regulation -- How lower eukaryotes contribute on our understanding of eIF4E-dependent translation -- Evolution of functionally divergent eIF4Es and their roles in the regulation of mRNA recruitment and developmental processes -- Evolution of eIF4E and eIF4G interactions in trypanosomes -- Evolution of the functionally divergent eIF4E family members in deuterostomes -- Evolution of the eIF2alpha kinases and translational control -- Evolution and use of eIF2alpha kinases in the apicomplexans and their role in life history of the parasites Plasmodium falciparum and Toxoplasma gondii -- Evolution of the TOR pathway and translational regulation -- Origin and diversification of eIF4E-binding proteins -- Evolution of the protein synthesis machinery in mitochondria -- Relationship between plant translation initiation factors and RNA viruses: An evolutionary perspective -- Evolution of miRNAs and RNA binding proteins in eukaryotes -- Evolution of silencing foci across eukaryotes -- Evolutionary conservation of the machineries coupling RNA transport with translation in eukaryotes
    Abstract: The €œómicś€ era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery
    Pages: IX, 564 p. 92 illus., 69 illus. in color. : online resource.
    ISBN: 9783319394688
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  • 34
    Keywords: Medicine ; Oncology ; Medical genetics ; Immunology ; Pneumology ; Biochemistry ; Biomedicine ; Biomedicine general ; Cancer Research ; Gene Function ; Immunology ; Pneumology/Respiratory System ; Medical Biochemistry ; Springer eBooks
    Description / Table of Contents: Polymorphisms of DNA repair genes and lung cancer in chromium exposure -- Circulating thrombospondin-2 and FGF-2 in patients with advanced non-small cell lung cancer: correlation with survival -- Mismatch repair gene polymorphisms and association with lung cancer development -- The potential of Wharton’s jelly derived mesenchymal stem cells in treating patients with cystic fibrosis -- Fatigue in sarcoidosis and exercise tolerance, dyspnea, and quality of life -- The rs1800471 polymorphism of TGFB1 gene, serum TGF-beta1 level and chronic kidney disease progression -- Immunological characteristics of children with Hashimoto's autoimmune thyroiditis -- Endostatin and cathepsin V in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis -- Posturography in patients with rheumatoid arthritis and osteoarthritis
    Abstract: Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips
    Pages: X, 71 p. 12 illus., 1 illus. in color. : online resource.
    ISBN: 9783319097527
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  • 35
    Keywords: Medicine ; Oncology ; Biochemistry ; Cytology ; Stem Cells ; Biomedicine ; Cancer Research ; Medical Biochemistry ; Cell Biology ; Stem Cells ; Springer eBooks
    Description / Table of Contents: Introduction -- Alcohol and breast cancer: Reconciling epidemiological and molecular data -- Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking -- Alcohol and Cancer: an Overview With special Emphasis on the Role of Acetaldehyde and Cytochrome P-4502E1 -- Implications of acetaldehyde-derived DNA adducts for understanding alcohol related carcinogenesis -- The role of iron in alcohol-mediated hepatocarcinogenesis -- Alcoholic Cirrhosis and Hepatocellular Carcinoma -- TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis -- Synergistic Toxic Interactions Between CYP2E1, LPS/TNFÎł and JNK/p38 MAP Kinase and their Implications in Alcohol-induced Liver Injury -- Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma -- Alcohol consumption, Wnt/b-catenin signaling and hepatocarcinogensis -- Alcohol and HCV: Implications for Liver Cancer -- Application of Mass Spectrometry-based Metabolomics in Identification of Early Noninvasive Biomarkers of Alcohol-Induced Liver Disease Using Mouse Model -- Alcohol Metabolism by Oral Streptococci and Interaction with Human Papillomavirus Leads to Malignant Transformation of Oral Keratinocytes -- Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers -- Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic cancers -- Alcohol, Carcinoembryonic Antigen Processing and Colorectal Liver Metastases -- Alcohol Consumption and Antitumor Immunity:℗ Dynamic Changes from Activation to Accelerated Deterioration of the Immune System -- A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma -- The effects of alcohol and aldehyde dehydrogenases on disorders of hematopoiesis -- The effect of alcohol on sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC) -- Transgenic Mouse Models for Alcohol Metabolism, Toxicity and Cancer -- Fetal alcohol exposure increases susceptibility to carcinogenesis and promotes tumor progression in prostate gland -- Fetal Alcohol Exposure and Mammary Tumorigenesis in Offspring:℗ Role of the Estrogen and Insulin-like Growth Factor Systems
    Abstract: This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer, cell signaling and cancer, stem cells, biomarkers and metabolomics, aerodigestive cancers, cancer and the immune system, and more. In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated and this volume gives a comprehensive overview of these advancements
    Pages: XVI, 436 p. 97 illus., 57 illus. in color. : online resource.
    ISBN: 9783319096148
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  • 36
    Keywords: Life sciences ; Medicine ; Biochemistry ; Life sciences ; Protein Science ; Protein Structure ; Molecular Medicine ; Atomic/Molecular Structure and Spectra ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Research Updates on Protein Folding -- Classes of Protein and their Folding -- Energetics of Protein Folding and Significance of Intermediates -- Involvement of Bioinformatics in Solving Protein Folding Problem
    Abstract: The book will discuss classes of proteins and their folding, as well as the involvement of bioinformatics in solving the protein folding problem. In vivo and in vitro folding mechanisms are examined, as well as the failures of in vitro folding, a mechanism helpful in understanding disease caused by misfolding.℗ The role of energy landscapes is also discussed and the computational approaches to these landscapes
    Pages: VII, 55 p. 6 illus., 4 illus. in color. : online resource.
    ISBN: 9783319125923
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  • 37
    Keywords: Life sciences ; Biochemistry ; Cytology ; Plant physiology ; Life sciences ; Plant physiology ; Oxidative Stress ; Plant Biochemistry ; Springer eBooks
    Description / Table of Contents: Compartmentalization of Reactive Oxygen Species and Nitric Oxide Production in Plant Cells – An Overview -- Established and Proposed Roles of Xanthine Oxidoreductase in Oxidative and Reductive Pathways in Plants -- The Roles of Plant Peroxidases in the Metabolism of Reactive Nitrogen Species and Other Nitrogenous Compounds -- Mitochondrial Signaling in Plants Under Hypoxia: Use of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS).-Feedback Loop of Non-Coupled Respiration and Reactive Oxygen Species Production in Plant Mitochondria -- Antioxidative Systems and Stress Tolerance - Insight from Wild and Cultivated Tomato Species -- The Role of Reactive Oxygen Species Under Ammonium Nutrition -- Allelopathic Compounds as Oxidative Stress Agents: Yes or NO -- The Role of Reactive Oxygen and Nitrogen Species in Bioenergetics, Metabolism and Signaling During Seed Germination -- ROS Signalling in Plant Embryogenesis.- “Nitrosative Door” in Seed Dormancy Alleviation and Germination -- Dissecting Nitric Oxide Signaling in Nucleus: Role of S-Nitrosylation in Regulating Nuclear Proteins -- Nitration and S-Nitrosylation: Two Post-Translational Modifications (Ptms) Mediated by Reactive Nitrogen Species (RNS) and Their Role in Signalling Processes of Plant Cells -- S-Nitrosoglutathione Reductase: A Key Regulator of S-Nitrosylation in Plant Development and Stress Responses -- Interaction of Calcium Signaling With Reactive Oxygen and Reactive Nitrogen Species
    Abstract: This book reviews the current state of information on reactive oxygen and nitrogen species and their role in cell communication during plant growth, development and adaptation to stress conditions. It addresses current research advances made in the area of reactive oxygen and nitrogen species (ROS and RNS) signaling. These free radical molecules are important in plant-microbe interactions, responses to abiotic stress, stomatal regulation and a range of developmental processes. Due to their short half-life, high diffusion capability and ability to react with different components in the cell, ROS and RNS participate in various processes connected with signaling and communication in plants. The book’s respective chapters address the latest advances made in the niche area of ROS and RNS in plants. It offers a valuable guide for researchers and students alike, providing insights into cutting-edge free radical research. The information on specialized topics presented is also highly relevant for applied fields such as food security, agricultural practices and medicinal use of plants
    Pages: VIII, 316 p. 171 illus., 157 illus. in color. : online resource.
    ISBN: 9783319100791
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  • 38
    Keywords: Life sciences ; Biochemistry ; Plant Ecology ; Plant physiology ; Life sciences ; Plant Ecology ; Plant physiology ; Plant Biochemistry ; Springer eBooks
    Description / Table of Contents: Improved Quality of Abattoir Wastewater Through Phytoremediation -- Phytoremediation of Contaminated Waters To Improve Water Quality -- On-Site And Full-Scale Applications of Phytoremediation To Repair Aquatic Ecosystems With Excess Metals -- Phytoremediation of Eutrophic Waters -- Phytoremediation of Water And Wastewater: On-Site And Full-Scale Applications -- Interaction of Algae-Bacteria Consortia: A New Application of Heavy Metals Bioremediation -- Heavy Metals Phytoremediation From Urban Waste Leachate By The Common Reed (Phragmites Australis) -- Cyanobacteria as Potential Options For Wastewater Treatment -- Phytoremediation Using Rhizobia -- Phytoremediation of Heavy Metals: The Use of Green Approaches To Clean The Environment -- Phytoremediation Using Leguminous Plants: Managing Cadmium Stress With Application of Arbuscular Mycorrhiza (Am) Fungi -- Phytoremediation of Copper-Contaminated Soil -- Phytoremediation of The Metalloid Selenium In Soil And Water -- Phytoremediation Using Microbial Communities: I -- Phytoremediation Using Microbial Communities: Ii -- Effects of Bio-Solids On The Transpiration Rate of Rainbow Pink (Dianthus Chinensis) Grown In Cadmium-Contaminated Soils -- Phytoremediation And The Electrokinetic Process: Potential Use For The Phytoremediation of Antimony And Arsenic -- Chromium Phyto-Transformation In Salt Marshes: The Role of Halophytes -- Molecular Mechanisms And The Phytoremediation of Heavy Metals From Coastal Water -- Lichens as An Alternative Biosorbent: A Review -- Phytoremediation In Constructed Wetlands -- Phytoremediation Using Algae And Macrophytes: I -- Phytoremediation Using Algae And Macrophytes: Ii -- Phytoremediation To Remove Metals/Metalloids From Soils -- Phytoremediation Using Terrestrial Plants -- Phytoremediation And Necrophytoremediation of Petrogenic Hydrocarbon-Contaminated Soils -- An Integrated Electrochemical-Phytoremediation Process For The Treatment of Industrial Wastewater -- Metal Accumulation Capability of Weeds And Their Utilization In Phytoremediation Technology
    Abstract: Volume two of this℗ dual volume series includes additional examples of the use of green plants and their associated communities to remove, degrade, or stabilize℗ contaminants entering the air, water and soil of a multitude of ecosystems. The chapters in this volume provide additional examples that illustrate how phytoremediation applications can serve as one of several useful components in the overall management and control of contaminants while℗ using relatively low cost solar driven physiological and biochemical mechanisms common in most plants. This text also has the added value of providing remediation options that offer minimal disruption to the ecosystem or habitat under repair. Phytoremediation: Management of Environmental Contaminants, Volume 2 presents its readers with new insights℗ into the advantages and disadvantages of using phytoremediation to manage the continuing threat of ecosystem degradation resulting from the interaction of contaminants and climate change
    Pages: XV, 366 p. 73 illus., 42 illus. in color. : online resource.
    ISBN: 9783319109695
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  • 39
    Keywords: Life sciences ; Toxicology ; Biochemistry ; Plant physiology ; Life sciences ; Plant physiology ; Plant Biochemistry ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction to stress in plants -- Mechanism of heavy metal toxicity and tolerance -- Mechanism of aluminium toxicity and tolerance -- Mechanism of arsenic toxicity and tolerance -- Mechanism of salt toxicity and tolerance -- Mechanism of drought stress and tolerance -- Mechanism of light stress and tolerance -- Mechanism of temperature stress and tolerance -- Mechanism of flood stress and tolerance -- Mechanism of UV-B stress and tolerance
    Abstract: This collection discusses the variety of specific molecular reactions by means of which plants respond to physiological and toxic stress conditions. It focuses on the characterization of the molecular mechanisms that underlie the induction of toxicity and the triggered responses and resistances. The nine chapters, all written by prominent researchers, examine heavy metal toxicity, aluminum toxicity, arsenic toxicity, salt toxicity, drought stress, light stress, temperature stress, flood stress and UV-B stress. In addition, information on the fundamentals of stress responses and resistance mechanisms is provided. The book addresses researchers and students working in the fields of plant physiology and biochemistry
    Pages: VI, 292 p. 48 illus., 8 illus. in color. : online resource.
    ISBN: 9783319133683
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  • 40
    Keywords: Philosophy (General) ; Medicine ; Psychiatry ; Behavioral Therapy ; Rehabilitation ; Psychology, clinical ; Psychology ; Clinical Psychology ; Psychiatry ; Biomedicine general ; Behavioral Therapy ; Rehabilitation ; Springer eBooks
    Description / Table of Contents: Preface -- Foreword -- Theoretical Background -- Practical Implementation of INT -- Therapy Requirements, Possible Applications and Indication -- Diagnostic Instruments, Treatment Planning and Controlling the Treatment Process -- Empirical Evidence of INT -- Therapy Materials for the Four Treatment Areas -- Index
    Abstract: Integrated Neurocognitive Therapy (INT) is a cognitive remediation therapy approach. INT is the first treatment manual comprising all MATRICS areas (Measurement and Treatment Research to Improve Cognition in Schizophrenia). The NIMH (National Institute of Mental Health, USA) initiated this MATRICS initiative. MATRICS defines 11 neurocognitive and social cognitive areas of functioning being relevant for patients with schizophrenia. The improvement of these areas in a group therapy is the main goal of INT. INT is based on IPT (Integrated Psychological Therapy, Roder et al 2010). It is a resource and a recovery oriented intervention to enhance also therapy motivation and self-esteem and to reduce negative symptoms. Therapy focuses especially on group processes and the exercises augment transfer and generalisation to daily life. As a meta goal INT intends to amend life quality and the reintegration of the patients in the community. The presented manual offers the clinicians a practically orientated guide for carrying out INT. The techniques and exercises (partly computer-based) are described in detail. Case examples point out specific therapeutic situations and teach the therapist how to cope with complicated group and individual demands. Assessment for patient selection, differential indication and therapy control within a multi-dimensional treatment and rehabilitation system are discussed. INT was evaluated successfully in an international randomised multi-centre study. In the meantime it is implemented in many clinical settings in German speaking countries.℗
    Pages: X, 141 p. 37 illus., 28 illus. in color. : online resource.
    ISBN: 9783319132457
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  • 41
    Keywords: Medicine ; Oncology ; Medical laboratories ; Biochemistry ; Biomedicine ; Cancer Research ; Biochemistry, general ; Laboratory Medicine ; Springer eBooks
    Abstract: This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer
    Pages: XI, 490 p. 87 illus., 68 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319207506
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  • 42
    Keywords: Life sciences ; Medicine ; Biochemistry ; Cytology ; Life sciences ; Apoptosis ; Biomedicine general ; Medical Biochemistry ; Springer eBooks
    Description / Table of Contents: Apoptosis: Pathways, Molecules and Beyond -- Caspases - key players in apoptosis -- Calpains and Granzymes: non-caspase proteases in cell death -- Cathepsins and HtrAs - multitasking proteases in programmed cell death -- Proteases in Apoptosis: Protocols and Methods -- Preclinical Animal Model and Non-invasive Imaging in Apoptosis
    Abstract: This book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics℗ are recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research
    Pages: XV, 245 p. 51 illus., 50 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319194974
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  • 43
    Keywords: Medicine ; Human Physiology ; Endocrinology ; Biochemistry ; Embryology ; Biomedicine ; Human Physiology ; Endocrinology ; Embryology ; Animal Biochemistry ; Springer eBooks
    Description / Table of Contents: Introduction ́€“Rodney Geisert -- History of Maternal Recognition of Pregnancy - Fuller W. Bazer -- The Role of Steroids Hormone Receptors in℗ the Establishment of Pregnancy in Rodents℗ ́€“℗ Nyssa R. Adams and Francesco J. DeMayo -- Transmembrane Mucin Expression and Function in Embryo Implantation and Placentation - Pamela E. Constantinou, Micaela Morgado and Daniel D. Carson -- Reflections on Rodent Implantation - Jeeyeon M. Cha and Sudhansu K. Dey -- The Role of Progesterone in Maternal Recognition of Pregnancy in Domestic Ruminants ́€“ Pat Lonergan and Niamh Forde -- Implantation and Establishment of Pregnancy in Ruminants - Thomas E. Spencer and Thomas R. Hansen -- Implantation and Establishment of Pregnancy in the Pig ́€“ Rodney D. Geisert, Gregory A. Johnson and Robert C. Burghardt -- Pregnancy Recognition and Implantation of the Conceptus in the Mare - Claudia Klein -- Implantation and Establishment of Pregnancy in Human and Non-Human Primates - Ren-Wei Su and Asgerally T. Fazleabas -- The Dog: Nonconformist, Not Only In Maternal Recognition Signaling - Mariusz P. Kowalewski, Aykut Gram, Ewa Kautz, Felix Graubner -- Embryonic Diapause and Maternal Recognition of Pregnancy in Diapausing Mammals - Marilyn B. Renfree -- Predicting Embryo Presence and Viability ́€“ Ky G. Pohler, Jonathon A. Green, Thomas W. Geary, R.F.G. Peres, M.H.C. Pereira, J.L.M. Vasconcelos and M.F. Smith -- Subject Index
    Abstract: Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics, along with the ability to selectively knockout genes of interest, have greatly advanced our understanding of the maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy.℗ This knowledge provides the basis for new research endeavors to address infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. This book brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed.℗ The reviews provide readers with the latest knowledge on the role of the endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved in the regulation of conceptus development.℗
    Pages: VI, 270 p. 23 illus., 18 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319158563
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  • 44
    Keywords: Medicine ; Cancer Research ; Human Physiology ; Molecular Biology ; Biochemistry ; Cell Physiology ; Biomedicine ; Molecular Medicine ; Cell Physiology ; Cancer Research ; Animal Biochemistry ; Human Physiology ; Springer eBooks
    Description / Table of Contents: 1) microRNA: the master key to precision medicine -- 2) MICRORNAS IN THE MALIGNANT TRANSFORMATION PROCESS -- 3) microRNA and chronic lymphocytic leukemia -- 4) microRNA and malignant lymphoma -- 5) microRNA and gastrointestinal stromal cancer -- 6) microRNA and pancreatic cancer -- 7) microRNA and colorectal cancer -- 8) microRNA and prostate cancer -- 9) Ovarian cancer -- 10) microRNA and breast cancer -- 11) microRNA and soft tissue sarcoma -- 12) microRNA and bone cancer
    Abstract: This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundamental themes. The text, which opens with a foreword by the renowned Dr. Carlo M. Croce, is enhanced by abundant color photographs, schemes, diagrams, and tables that fully support and complement the content. microRNA: Cancer is an ideal companion to both microRNA: Basic Science and microRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice
    Pages: XI, 235 p. 17 illus., 16 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319237305
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  • 45
    Keywords: Medicine ; Human Physiology ; Molecular Biology ; Biochemistry ; Cell Physiology ; Atomic structure ; Molecular Structure ; Spectra ; Biomedicine ; Molecular Medicine ; Cell Physiology ; Atomic/Molecular Structure and Spectra ; Animal Biochemistry ; Human Physiology ; Springer eBooks
    Description / Table of Contents: -- 1) microRNA and personalized medicine -- 2) microRNA and chronic pain -- 3) microRNA and multiple sclerosis -- 4) microRNA and epilepsy℗ -- 5) microRNA and autism -- 6) microRNAs and fragile X syndrome -- 7) microRNAs and neurodegenerative disorders -- 8) microRNA and metabolism: focus on mitochondria -- 9) microRNA in cerebrovascular diseases ℗ -- 10) ℗ microRNA and cardiac regeneration -- 11) ℗ microRNA and arterial -- 12) ℗ microRNA and pulmonary hypertension . - 13) microRNA and diabetic kidney disease -- 14) ℗ MicroRNA and kidney transplantation -- 15) microRNA and wound healing -- 16) microRNA in dermatology -- 17) microRNA and allergy -- 18) Endometriosis -- 19) microRNA role in human -- 20) microRNA and hepatitis B -- 21) BIO microRNA and aging -- 22) microRNA and doping -- 23) microRNA profiling
    Abstract: This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within todaý€™s initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters ℗ which outline the emerging role of microRNAS in doping and detail microRNA profiling. microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Science and microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice
    Pages: XII, 429 p. 36 illus., 26 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319226712
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Medicine ; Chemistry, Organic ; Biochemistry ; Life sciences ; Protein Science ; Biomedicine general ; Organic Chemistry ; Springer eBooks
    Description / Table of Contents: Sequences -- Structures -- Systems
    Abstract: This book describes more than 60 web-accessible computational tools for protein analysis and is totally practical, with detailed explanations on how to use these tools and interpret their results and minimal mentions to their theoretical basis (only when that is required for making a better use of them). It covers a wide range of tools for dealing with different aspects of proteins, from their sequences, to their three-dimensional structures, and the biological networks they are immersed in. The selection of tools is based on the experience of the authors that lead a protein bioinformatics facility in a large research centre, with the additional constraint that the tools should be accessible through standard web browsers without requiring the local installation of specific software, command-line tools, etc. The web tools covered include those aimed to retrieve protein information, look for similar proteins, generate pair-wise and multiple sequence alignments of protein sequences, work with protein domains and motifs, study the phylogeny of a family of proteins, retrieve, manipulate and visualize protein three-dimensional structures, predict protein structural features as well as whole three-dimensional structures, extract biological information from protein structures, summarize large protein sets, study protein interaction and metabolic networks, etc. The book is associated to a dynamic web site that will reflect changes in the web addresses of the tools, updates of these, etc. It also contains QR codes that can be scanned with any device to direct its browser to the tool web site. This monograph will be most valuable for researchers in experimental labs without specific knowledge on bioinformatics or computing
    Pages: VIII, 106 p. 40 illus. in color. : online resource.
    ISBN: 9783319127279
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