Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • DKFZ Publication Database  (2)
  • Journal article published  (2)
  • CANCER  (1)
  • CARCINOMA IN-SITU  (1)
  • -
Collection
  • DKFZ Publication Database  (2)
Source
  • 1
    Keywords: CANCER ; tumor ; FOLLOW-UP ; RISK ; TIME ; INFECTION ; breast cancer ; MICROMETASTASES ; PROGNOSTIC-SIGNIFICANCE ; body mass index ; PAIN ; ISOLATED TUMOR-CELLS ; ASPIRATION ; BIOPSY MORBIDITY ; Bone marrow puncture ; DTCs ; PRIMARY SURGERY ; Side-effects
    Abstract: BACKGROUND AND AIM: In breast cancer patients, intraoperative bone marrow puncture (BMP) with positive detection of disseminated tumor cells has been reported to predict unfavorable clinical outcome due to increased risk of recurrence. In this study, we prospectively assessed BMP-associated untoward side-effects. METHODS: Fifty-eight consecutive breast cancer patients were prospectively explored after intraoperative BMP for postoperative pain (visual analogue scale, VAS) and complications in terms of infection, hematoma, and sensibility disorder. Furthermore, the impact of BMP on hospital stay duration was analyzed in 254 patients. RESULTS: In all subgroups analyzed, during five postoperative days patients complained about minor pain only at the site of BMP (VAS 〈 1) while the corresponding pain scores were significantly higher for the area of the operated breast. Post-BMP iliac crest hematomas were encountered in 13 out of 58 patients (22.4%) who were significantly older (p = 0.04), less frequently smokers (p = 0.02), and presented with higher body mass index (p = 0.01) than controls. Within the area of BMP no signs of infection or sensibility disorders were observed. Comparison of patients with and without BMP did not show any significant difference in postoperative hospital stay duration. CONCLUSION: Referring to the potential clinical benefit of intraoperative BMP its prospectively assessed adverse side-effects appear relatively mild and thus acceptable.
    Type of Publication: Journal article published
    PubMed ID: 20621481
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    Breast 22 (Suppl. 2), S66-72 
    Keywords: UP-REGULATION ; DUCTAL CARCINOMA ; CARCINOMA IN-SITU ; MAMMARY EPITHELIAL-CELLS ; BONE METASTASES ; OSTEOPONTIN EXPRESSION ; LYSYL OXIDASE ; TENASCIN-C ; PLASMINOGEN/PLASMIN SYSTEM ; HYALURONAN RECEPTORS
    Abstract: The extracellular matrix (ECM) is composed of highly variable and dynamic components that regulate cell behavior. The protein composition and physical properties of the ECM govern cell fate through biochemical and biomechanical mechanisms. This requires a carefully orchestrated and thorough regulation considering that a disturbed ECM can have serious consequences and lead to pathological conditions like cancer. In breast cancer, many ECM proteins are significantly deregulated and specific matrix components promote tumor progression and metastatic spread. Intriguingly, several ECM proteins that are associated with breast cancer development, overlap substantially with a group of ECM proteins induced during the state of tissue remodeling such as mammary gland involution. Fibrillar collagens, fibronectin, hyaluronan and matricellular proteins are matrix components that are common to both involution and cancer. Moreover, some of these proteins have in recent years been identified as important constituents of metastatic niches in breast cancer. In addition, specific ECM molecules, their receptors or enzymatic modifiers are significantly involved in resistance to therapeutic intervention. Further analysis of these ECM proteins and the downstream ECM mediated signaling pathways may provide a range of possibilities to identify druggable targets against advanced breast cancer.
    Type of Publication: Journal article published
    PubMed ID: 24074795
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...