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    Keywords: brain ; RECEPTOR ; CANCER ; EXPRESSION ; human ; DISEASE ; liver ; EPITHELIA ; FAMILY ; primary ; INDUCTION ; etiology ; PEPTIDES ; EPITHELIAL-CELLS ; MUCINS ; CELL-MIGRATION ; CHRONIC HEPATITIS ; CIRRHOSIS ; DEFENSE ; DIGESTIVE-TRACT ; HUMAN SPASMOLYTIC POLYPEPTIDE ; intrahepatic biliary tree,mucin,primary biliary cirrhosis,repair,trefol factor family
    Abstract: Background/Aim: Trefoil factor family (TFF)1,2,3 are involved in a homeostasis/repair process of mucosal epithelia. In this study, the significance of TIFF family and deleted in the malignant brain tumor-1 (DMBT1), a putative receptor of TFF2, in the intrahepatic biliary tree was investigated in normal and diseased livers. Materials and Methods: Expression of TFF1,2,3 and DMBT1 were examined immunohistochemically in primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic viral hepatitis (CVH), extrahepatic biliary obstruction (EBO), and normal livers. Results: In normal livers, TFF1,3 and DMBT1 were infrequently detectable in large and rarely in small bile ducts, respectively. TFF2 was not detectable in large bile ducts. In large bile duct diseases (PSC and EBO), expression of TFF3 and DMBT1 were increased. In small bile duct diseases (PBC and CVH), expression of TFF2/DMBT1 was induced in moderately to severely damaged ducts irrespective of etiology. Conclusion: The intrahepatic biliary tree shows a site-characteristic expression and induction of TIFF 1,2,3 and DMBT1. In large bile ducts, TIFF 1,3 were constitutively expressed and increased in pathologic bile ducts. In small bile ducts, TFF2/DMBT1 is induced in damaged ducts irrespective of etiologies. However, the cytoprotective/repair property of TFF2/DMBT1 may not be enough to prevent the following bile duct loss in PBC
    Type of Publication: Journal article published
    PubMed ID: 15101998
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