Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • COLORECTAL-CANCER  (5)
Keywords
  • 1
    Keywords: CANCER ; Germany ; screening ; TOOL ; HISTORY ; incidence ; MORTALITY ; POPULATION ; RISK ; RISKS ; TIME ; PATIENT ; REDUCTION ; colon ; prevention ; AGE ; colorectal cancer ; COLORECTAL-CANCER ; COST-EFFECTIVENESS ; case-control studies ; FEASIBILITY ; RELATIVE RISK ; RECTAL-CANCER ; case-control study ; RE ; INCREASE ; case control studies ; INTERVAL ; CANCER INCIDENCE ; odds ratio ; population-based ; AVERAGE-RISK ; ENDOSCOPY ; FLEXIBLE SIGMOIDOSCOPY ; SERVICES TASK-FORCE
    Abstract: Background and aims: Screening colonoscopy is thought to be a powerful and cost-effective tool to reduce colorectal cancer incidence and mortality. Whether and when colonoscopy with negative findings has to be repeated is not well defined. The aim of this study was to assess the long term risk of clinically manifest colorectal cancer among subjects with negative findings at colonoscopy. Patients: 380 cases and 485 controls participating in a population based case-control study in Germany. Methods: Detailed history and results of previous colonoscopies were obtained by interview and from medical records. Adjusted relative risks of colorectal cancer among subjects with a previous negative colonoscopy compared with those without previous colonoscopy were estimated according to time since colonoscopy. Results: Subjects with previous negative colonoscopy had a 74% lower risk of colorectal cancer than those without previous colonoscopy (adjusted odds ratio (aOR) = 0.26 (95% confidence interval, 0.16 to 0.40)). This low risk was seen even if the colonoscopy had been done up to 20 or more years previously. Particularly low risks were seen for sigma cancer (aOR = 0.13 (0.04 to 0.43)) and for rectal cancer (aOR = 0.19 (0.09 to 0.39)), and after a negative screening colonoscopy at ages 55 to 64 (aOR = 0.17 (0.08 to 0.39)) and older (aOR = 0.21 (0.10 to 0.41)). Conclusions: Subjects with negative findings at colonoscopy are at very low risk of colorectal cancer and might not need to undergo repeat colonoscopy for 20 years or more, if at all. The possibility of extending screening intervals to 20 years or more might reduce complications and increase the feasibility and cost-effectiveness of colonoscopy based screening programmes
    Type of Publication: Journal article published
    PubMed ID: 16469791
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CANCER ; CELLS ; EXPRESSION ; carcinoma ; CELL ; Germany ; human ; MODEL ; GENES ; transcription ; DIFFERENTIATION ; TISSUE ; TIME ; IFN-GAMMA ; MECHANISM ; TRANSCRIPTION FACTOR ; tumour ; mechanisms ; T cell ; T cells ; T-CELL ; T-CELLS ; SUPPRESSION ; NO ; TRANSCRIPTION FACTORS ; HUMANS ; METASTASIS ; colorectal cancer ; COLORECTAL-CANCER ; metastases ; EFFICIENT ; LYMPHOCYTES ; COLORECTAL CANCERS ; PROBES ; PERFORIN ; T-LYMPHOCYTES ; T lymphocyte ; REJECTION ; OVEREXPRESSION ; EFFECTOR ; T lymphocytes ; molecular ; MOLECULAR-MECHANISM ; FOXP3 ; TGF-BETA ; MOLECULAR-MECHANISMS ; LEVEL ; function ; lymph node metastases ; LYMPH-NODE ; correlation ; EVALUATE ; GUT ; CANCERS ; regulatory T cells ; colorectal ; IFN-GAMMA PRODUCTION ; MEDIATED SUPPRESSION ; REGULATED EXPRESSION
    Abstract: Background/aims: An efficient cytolytic T cell function is essential for immune mediated rejection of colorectal cancer. However, the molecular mechanisms driving T cell mediated cancer rejection are still poorly understood. Here, we assessed the relevance of the T-box transcription factor eomesodermin in colorectal cancer. Methods/results: By analysing tissue probes from 88 different colorectal tumours, a significant ( p〈0.02) inverse correlation between eomesodermin expression in colorectal cancers and the presence of lymph node metastases could be shown, whereas no such correlation was noted for the master transcription factor of regulatory T cells, FoxP3 and CD8alpha expression. To evaluate whether this effect might be due to effects of eomesodermin on tumour infiltrating CD8 T cells, we subsequently analysed the regulated expression and function of this transcription factor in human T cells. Whereas overexpression of this factor induced perforin but not granzyme expression, siRNA mediated suppression of eomesodermin expression led to significantly reduced IFN-gamma production, perforin levels and cytolytic activity of CD8 T cells. Furthermore, TGF-beta and IL4 could be identified as important inducer of eomesodermin expression. Conclusion: These data define for the first time a regulatory role of eomesodermin for CD8 T cell activity in humans. Our findings are consistent with a model in which eomesodermin expression in tumour infiltrating T cells regulates cytolytic functions of CD8 T cells via perforin expression. These data provide novel insights into control mechanisms governing the functional activity of human CD8 T lymphocytes via T-box transcription factors in cancer
    Type of Publication: Journal article published
    PubMed ID: 17566017
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: RISK ; SITE ; PERFORMANCE ; COLORECTAL-CANCER ; RATES ; COLON-CANCER ; microsatellite instability ; PREDICTORS ; SCREENING COLONOSCOPY ; INCOMPLETE COLONOSCOPY
    Abstract: ObjectiveThe risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy.MethodsA population-based case-control study was conducted in Southern Germany in 2003-7. Sociodemographic and tumour characteristics were compared among 78 patients with interval cancers occurring 1-10 years after a negative colonoscopy and 433 colorectal cancers detected at screening. In addition, the indication for the preceding negative colonoscopy and its completeness were compared between patients with interval cancers and 515 controls with a preceding negative colonoscopy.Results56.4% of interval cancers occurred among women compared with 33.7% of cases detected by screening (p=0.0001). After adjustment for covariates, female sex (OR 2.28, 95% CI 1.35 to 3.83) and location in the caecum or ascending colon (OR 1.98, 95% CI 1.17 to 3.35) were independently associated with occurrence of interval cancers. The preceding negative colonoscopy was more commonly conducted because of a positive faecal occult blood test (26.0% vs 12.9%, p=0.009) and was more often incomplete (caecum not reached: 18.1% vs 6.7%, p=0.001) among interval cancer cases than among controls. Characteristics of the preceding negative colonoscopy strongly and independently associated with occurrence of interval cancers were follow-up of a positive faecal occult blood test among men (OR 5.49, 95% CI 2.10 to 14.35) and incompleteness among women (OR 4.38, 95% CI 1.69 to 11.30).ConclusionsThe observed patterns suggest that a substantial proportion of interval cancers are due to neoplasms missed at colonoscopy and are potentially preventable by enhanced performance of colonoscopy.
    Type of Publication: Journal article published
    PubMed ID: 22200840
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: CANCER ; Germany ; screening ; incidence ; POPULATION ; RISK ; PATIENT ; colon ; ADENOMAS ; PROGRESSION ; DESIGN ; AGE ; WOMEN ; colorectal cancer ; MEN ; COLORECTAL-CANCER ; COST-EFFECTIVENESS ; RATES ; LINE ; EVOLUTION ; MALIGNANT TRANSFORMATION ; NATIONWIDE ; CARRIERS ; INDIVIDUALS ; SERIES ; PREVALENCE ; REGISTRY ; RE ; INCREASE ; TRANSITION ; colonoscopy ; CANCER INCIDENCE ; GUT ; REGISTRIES ; colorectal ; - ; GRADIENT ; LARGE-INTESTINE ; POLYPS ; SCREENING COLONOSCOPY ; adenoma ; YOUNGER
    Abstract: Objectives: To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer ( CRC) incidence. Design: Registry based study. Setting: National screening colonoscopy programme in Germany. Patients: Participants of screening colonoscopy in 2003 and 2004 ( n = 840 149). Main outcome measures: Advanced adenoma prevalence, colorectal cancer incidence, annual and 10 year cumulative risk of developing CRC among carriers of advanced adenomas according to sex and age ( range 55 - 80+ years). Results: The age gradient is much stronger for CRC incidence than for advanced adenoma prevalence. As a result, projected annual transition rates from advanced adenomas to CRC strongly increase with age ( from 2.6% in age group 55 - 59 years to 5.6% in age group 〉= 80 years among women, and from 2.6% in age group 55 - 59 years to 5.1% in age group 〉= 80 years among men). Projections of 10 year cumulative risk increase from 25.4% at age 55 years to 42.9% at age 80 years in women, and from 25.2% at age 55 years to 39.7% at age 80 years in men. Conclusions: Advanced adenoma transition rates are similar in both sexes, but there is a strong age gradient for both sexes. Our estimates of transition rates in older age groups are in line with previous estimates derived from small case series in the pre-colonoscopy era independent of age. However, our projections for younger age groups are considerably lower. These findings may have important implications for the design of CRC screening programmes
    Type of Publication: Journal article published
    PubMed ID: 17591622
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    facet.materialart.
    facet.materialart.
    Gut 63 (6), 865-866 
    Keywords: RISK ; COLORECTAL-CANCER
    Type of Publication: Journal article published
    PubMed ID: 23929693
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...