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  • DIAGNOSIS  (2)
  • 1
    Keywords: tumor ; Germany ; DIAGNOSIS ; imaging ; GENE ; TUMORS ; MARKER ; treatment ; MUTATION ; MARKERS ; MUTATIONS ; tomography ; adenocarcinoma ; sensitivity ; pathology ; COMPLICATIONS ; INITIATION ; COLONY-STIMULATING FACTOR ; GENE-MUTATIONS ; pancreas ; DUCTAL ADENOCARCINOMA ; methods ; pancreatic ; complication ; PHASE-I TRIAL ; FINE-NEEDLE-ASPIRATION ; K-RAS MUTATIONS ; technique ; CYSTIC LESIONS ; DEGUM INQUIRY ; ENDOSCOPIC ULTRASOUND ; endosonographically guided biopsy ; EUS-GUIDED FNA ; fine needle biopsy ; HIGH-SENSITIVITY ; indications ; MUCINOUS TUMORS ; NEEDLE BIOPSIES ; pancreas biopsy ; Sensitivity and Specificity
    Abstract: Pancreatic biopsy is an invasive diagnostic method that is only performed when all other diagnostic measures for establishing the diagnosis of a tumorous lesion of the pancreas have failed. Because of the advances in modern imaging techniques, fine needle biopsy of the pancreas guided by ultrasonography, computer tomography or endosonography has become a reliable method that allows the diagnosis of ductal adenocarcinoma or any of the other, rarer pancreatic tumors with high sensitivity and specificity. Complications are rare, particularly with the endosonographically guided biopsy. A new biopsy indication is the demonstration of certain markers or gene mutations that are needed for the initiation of special treatments, e.g. EGFR-Cetuximab
    Type of Publication: Journal article published
    PubMed ID: 15630570
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  • 2
    Keywords: CANCER ; EXPRESSION ; Germany ; human ; PROSTATE ; THERAPY ; DIAGNOSIS ; GENE ; GENES ; PROTEIN ; PROTEINS ; validation ; BIOMARKERS ; IDENTIFICATION ; PROGRESSION ; prostate cancer ; PROSTATE-CANCER ; FUSION ; TARGETS ; SINGLE ; molecular biology ; THERAPIES ; TISSUE MICROARRAYS ; development ; HIGH-THROUGHPUT ; USA ; CANCERS ; TARGETED THERAPY ; ANNEXIN A3
    Abstract: Significant cellular alterations required for the development and progression of cancers are detectable at the molecular level and represent potential targets for gene-specific therapies. Modern chip techniques allow the parallel analysis of virtually all known human genes and proteins in a single experiment. Using modern high-throughput techniques, numerous potential new biomarkers for the diagnosis and prediction of prostate cancer have been identified. However, so far none of these markers has improved clinical practice. One of the most important challenges in the coming years is the extensive clinical validation of molecular data using clinically relevant end points. For this venture the pivotal prerequisite is the availability of large, comprehensively annotated and standardized high-quality bioresources
    Type of Publication: Journal article published
    PubMed ID: 19139898
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