Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Germany  (4,905)
Collection
Language
  • 1
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  4th International Meeting of the German Association of Midwifery Science (DGHWi); 20180216-20180216; Mainz; DOC18dghwiP16 /20180213/
    Publication Date: 2018-02-14
    Keywords: Midwifery training ; university qualification ; Germany ; Hebammenausbildung ; Hochschule ; Deutschland ; ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2018-01-24
    Description: Introduction: It is discussed whether real world data can be used in health technology assessment. Following it is of interest whether routinely collected data for quality assurance (QA) in the hospital sector is feasible to address epidemiologic questions in kidney transplantation in the AMNOG process in Germany. Objectives: To investigate the proportion of kidney transplants classified as from so-called standard criteria donors (SCD) and from expanded criteria donors (ECD) in Germany and to study the age distribution.Methods: After granted use by the Federal Joint Committee (G-BA), the data analysis was carried out by the AQUA institute, and a SPSS code was developed. Special challenge was the complex definition of SCD/ECD criteria that, in addition to donor age, takes into account combinations of donor diagnoses, creatinine, and cold ischemia time.Results: Age analyses could be performed in all patients. Median age of the adult transplant recipients in Germany was 54 years in 2012 as well as in 2013, range 18-85 and 18-82 years and a mean (SD) of 53 (14) and 52 (14) years, respectively. 63.5% (2012) and 62.5% (2013) of recipients were male. Classification in SCD/ECD transplants could be performed for 2,083 of 2,461 patients (85%; 2012) and for 1,795 of 2,079 patients (86%; 2013). Of all classifiable transplants 61.4% (2012) and 66.5% (2013) were SCD transplants. Total project time from the request to results was <6 months.Conclusions: The use of data routinely collected for QA in the hospital sector is feasible to address epidemiologic questions in kidney transplantation in the AMNOG process in Germany, which is basically following the systematic of an HTA process. All patients with kidney transplants are represented thus avoiding sampling error. Limitations include the availability of all necessary data in the QA data set. Within <6 months' time with reasonable resources it was possible to meet timelines. The analyses were accepted by the authorities.
    Description: Hintergrund: Es wird diskutiert, ob Routinedaten im Rahmen von Health Technology Assessments (HTA) genutzt werden können. Zur Beantwortung von epidemiologischen Fragestellungen zur Nierentransplantation in Deutschland im AMNOG Verfahren sollten Qualitätssicherungsdaten nach §137a SGB V genutzt werden. Ziele: Die Altersverteilung von Spendern und erwachsenen Empfängern für die Nierentransplantation in Deutschland sollte möglichst exakt ermittelt werden. Zusätzlich sollte der Anteil von Transplantationen nach den sogenannten Standardkriterien (SCD) und erweiterten Kriterien (ECD) bestimmt werden.Methoden: Nach positiver Beantwortung des formalen Antragsverfahrens durch den gemeinsamen Bundesausschuss (G-BA) erfolgte die Datenanalyse durch das AQUA-Institut basierend auf einer SPSS-Abfrage. Eine besondere Herausforderung hierbei war die komplexe Definition der sogenannten Standardkriterien (SCD) und erweiterten Kriterien (ECD), die neben Spenderalter auch Kombinationen von Spenderdiagnosen sowie dem Laborwert Kreatinin sowie die kalte Ischämiezeit berücksichtigt. Ergebnisse: Für die Altersanalysen ließen sich alle Patienten klassifizieren. Das mediane Alter der erwachsenen Transplantatempfänger in Deutschland betrug im Jahr 2012 und Jahr 2013 jeweils 54 Jahre, bei einer Spannweite von 18-85 bzw. 18-82 Jahren und einem Mittelwert (Standardabweichung) von 53 (14) bzw. 52 (14) Jahren. 63,5% (2012) bzw. 62,5% (2013) der Empfänger waren Männer. Die komplexe Klassifikation in SCD/ECD Transplantate war bei 2.083 von 2.461 Patienten (85%) im Jahr 2012 bzw. 1.795 von 2.079 Patienten (86%) im Jahr 2013 möglich. Es ergab sich ein Anteil von SCD-Transplantationen an allen klassifizierbaren Transplantaten von 61,4% im Jahr 2012 und 66,5% im Jahr 2013. Die Gesamtlaufzeit des Projektes vom Tag der Beantragung bis zum finalen Ergebnis betrug unter 6 Monaten.Fazit: Die Nutzung der im Rahmen der externen stationären Qualitätssicherung gem. §137a SGB V erhobenen Daten für epidemiologische Fragestellungen im AMNOG-Verfahren ist möglich. Im Bereich Nierentransplantation besteht eine Vollerhebung für Deutschland, so dass Stichprobenfehler vermieden werden und qualitativ hochwertige, repräsentative Auswertungen erfolgen können. Wesentliche Limitation der Sekundärdatenanalyse ist der zur Verfügung stehende Umfang des Datensatzes, der primär auf die Zwecke der externen Qualitätssicherung ausgerichtet ist. Mit einer Projektlaufzeit <6 Monaten war es möglich, die Fristen einzuhalten und die Analysen wurden vom gemeinsamen Bundesausschuss akzeptiert.
    Keywords: kidney transplantation ; kidney transplant ; epidemiology ; incidence ; prevalence ; Germany ; Nierentransplantation ; Nierentransplantat ; Epidemiologie ; Inzidenz ; Prävalenz ; Deutschland ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Call number: G260:34
    Keywords: Drug Utilization / trends ; Germany
    Pages: xiii, 906 p.
    ISBN: 9783662573853
    Signatur Availability
    G260:34 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 4
    Call number: QV738GG4:6/2018 ; M019:53
    Keywords: Pharmaceutical Preparations ; Germany
    Notes: Auch online verfügbar über die Homepage der Zentralbibliothek.
    Pages: various pagings
    Edition: 58. Ausg.
    ISBN: 9783946057314
    Signatur Availability
    QV738GG4:6/2018 available
    M019:53 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 5
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS German Medical Science; VOL: 15; DOC19 /20171219/
    Publication Date: 2017-12-19
    Description: Aim: The goal of this study was to identify potential risk factors for ectopic pregnancy in women followed in German gynecological practices.Methods: The present study included pregnant women diagnosed with ectopic pregnancy and pregnant women without ectopic pregnancy followed in 262 gynecological practices between January 2012 and December 2016. The effects of demographic and clinical variables on the risk of developing ectopic pregnancy were estimated using a multivariate logistic regression model. Results: This study included 3,003 women with ectopic pregnancy and 97,194 women without ectopic pregnancy. The mean age was 31.4 years (SD=5.9 years) in ectopic pregnancy patients and 31.1 years (SD=5.6 years) in non-ectopic pregnancy patients. Women aged 36-40 (OR=1.12) and 41-45 years (OR=1.46) were at a higher risk of ectopic pregnancy than women aged 31-35 years. Prior ectopic pregnancy was strongly associated with a risk of recurring ectopic pregnancy (OR=8.17). Prior genital surgery (OR=2.67), endometriosis (OR=1.51), and eight other gynecological diseases were also positively associated with ectopic pregnancy (ORs ranging from 1.19 to 2.06). Finally, there was a 1.80-fold increase in women previously diagnosed with psychiatric disorders.Conclusions: Prior ectopic pregnancy and prior genital surgery were strongly associated with ectopic pregnancy in women followed in German gynecological practices. Psychiatric diseases had an additional impact on the risk of ectopic pregnancy.
    Description: Ziel: Das Ziel dieser Studie war es, potentielle Risikofaktoren für eine Extrauteringravidität bei in deutschen gynäkologischen Praxen behandelten Frauen zu identifizieren.Methodik: Die vorliegende Studie umfasste schwangere Frauen in 262 gynäkologischen Praxen, bei denen zwischen Januar 2012 und Dezember 2016 eine Extrauteringravidität diagnostiziert wurde sowie schwangere Kontrollen ohne Extrauteringravidität. Die Auswirkungen der demografischen und klinischen Variablen auf das Risiko einer Extrauteringravidität wurden anhand eines multivariaten logistischen Regressionsmodells geschätzt. Ergebnisse: Diese Studie umfasste 3.003 Frauen mit Extrauteringravidität und 97.194 Frauen ohne Extrauteringravidität. Das Durchschnittsalter betrug 31,4 Jahre (SA=5,9 Jahre) bei den Patientinnen mit Extrauteringravidität und 31,1 Jahre (SA=5,6 Jahre) bei den Patientinnen ohne Extrauteringravidität. Frauen Im Alter zwischen 36-40 (OR=1,12) und 41-45 Jahren (OR=1,46) hatten ein höheres Risiko einer Extrauteringravidität als Frauen im Alter zwischen 31-35 Jahren. Eine vorhergegangene Extrauteringravidität stand in engem Zusammenhang mit dem Risiko einer erneuten Extrauteringravidität (OR=8,17). Vorhergegangene Operation im Genitalbereich (OR=2,67), Endometriose (OR=1,51) und acht weitere gynäkologische Erkrankungen waren ebenfalls positiv mit Extrauteringravidität assoziiert (ORs zwischen 1,19 und 2,06). Zu guter Letzt zeigte sich bei Frauen mit einer vorherigen Diagnose einer psychiatrischen Störung ein 1,8-facher Anstieg des Risikos einer Extrauteringravidität.Schlussfolgerungen: Vorhergegangene Extrauteringravidität und Operation im Genitalbereich waren eng mit Extrauteringravidität bei in deutschen gynäkologischen Praxen behandelten Frauen assoziiert. Psychiatrische Erkrankungen hatten einen zusätzlichen Einfluss auf das Risiko einer Extrauteringravidität.
    Keywords: ectopic pregnancy ; risk factors ; Germany ; retrospective study ; Extrauteringravidität ; Risikofaktoren ; Deutschland ; retrospektive Studie ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS German Medical Science; VOL: 15; DOC08 /20170426/
    Publication Date: 2017-10-12
    Description: Background: Only few authors have analyzed the impact of workplace conflicts and the resulting stress on the risk of developing cardiovascular disorders. The goal of this study was to analyze the association between workplace conflicts and cardiovascular disorders in patients treated by German general practitioners. Methods: Patients with an initial documentation of a workplace conflict experience between 2005 and 2014 were identified in 699 general practitioner practices (index date). We included only those who were between the ages of 18 and 65 years, had a follow-up time of at least 180 days after the index date, and had not been diagnosed with angina pectoris, myocardial infarction, coronary heart diseases, or stroke prior to the documentation of the workplace mobbing. In total, the study population consisted of 7,374 patients who experienced conflicts and 7,374 controls for analysis. The main outcome measure was the incidence of angina pectoris, myocardial infarction, and stroke correlated with workplace conflict experiences. Results: After a maximum of five years of follow-up, 2.9% of individuals who experienced workplace conflict were affected by cardiovascular diseases, while only 1.4% were affected in the control group (p-value <0.001). Workplace conflict was associated with a 1.63-fold increase in the risk of developing cardiovascular diseases. Finally, the impact of workplace conflict was higher for myocardial infarction (OR=2.03) than for angina pectoris (OR=1.79) and stroke (OR=1.56). Conclusions: Overall, we found a significant association between workplace conflicts and cardiovascular disorders.
    Description: Hintergrund: Der Einfluss der Konflikte am Arbeitsplatz und des daraus resultierenden Stresses auf das kardiovaskuläre Risiko wurde bis jetzt nur selten untersucht. Das Ziel dieser Studie bestand in der Analyse der Assoziation zwischen Arbeitsplatzkonflikterfahrungen und kardiovaskulären Erkrankungen bei Patienten in hausärztlichen Praxen.Methoden: Patienten mit initialer Dokumentation einer Arbeitsplatzkonflikterfahrung zwischen 2005 und 2014 (Indexdatum) wurden in 699 hausärztlichen Praxen identifiziert. Nur Patienten im Alter zwischen 18 und 65 Jahren, die über mindestens 180 Tage nach dem Indexdatum beobachtet werden konnten und keine Diagnosen von Angina Pectoris, Myokardinfarkt, koronarer Herzerkrankung und Schlaganfall vor dem Indexdatum hatten, wurden in die Analyse eingeschlossen. Insgesamt wurden 7.374 Patienten mit einer Arbeitsplatzkonflikterfahrung sowie 7.374 Patienten ohne Arbeitsplatzkonflikterfahrung (Kontrollgruppe) analysiert. Der Zielparameter war die Inzidenz von Angina Pectoris, Myokardinfarkt, koronarer Herzerkrankung und Schlaganfall abhängig von Arbeitsplatzkonflikterfahrungen.Ergebnisse: Innerhalb der maximal fünf Beobachtungsjahre wurde bei 2,9% der Personen mit der Erfahrung eines Arbeitsplatzkonfliktes, aber nur bei 1,4% in der Kontrollgruppe eine kardiovaskuläre Erkrankung diagnostiziert (p-Wert <0,001). Arbeitsplatzkonflikterfahrung war mit 1,63-fach erhöhtem Risiko für eine kardiovaskuläre Erkrankung assoziiert Der Einfluss war viel höher für Myokardinfarktrisiko (OR=2,03) verglichen mit dem Risiko für Angina Pectoris (OR=1,79) und Schlaganfall (OR=1,56). Schlussfolgerungen: Wir fanden eine signifikante Assoziation zwischen Arbeitsplatzkonflikterfahrungen und kardiovaskulären Erkrankungen.
    Keywords: workplace conflicts ; cardiovascular diseases ; myocardial infarction ; general practices ; Germany ; Arbeitsplatzkonflikt ; kardiovaskuläre Erkrankungen ; Myokardinfarkt ; Hausarzt ; Deutschland ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS German Medical Science; VOL: 15; DOC15 /20170925/
    Publication Date: 2017-09-25
    Description: Both Germany and the United States of America have a long tradition of science and medical excellence reaching back as far as the nineteenth century. The same tribute must be paid to the medical educational system in both countries. Despite significant initial similarities and cross-inspiration, the paths from enrolling in a medical university to graduating as a medical doctor in Germany and the US seem to have become much different. To fill a void in literature, the authors' objective therefore is to delineate both structures of medical education in an up-to-date review and examine their current differences and similarities. Recent medical publications, legal guidelines of governmental or official organizations, articles in media, as well as the authors' personal experiences are used as sources of this report.Tuition loans of over $200,000 are not uncommon for students in the US after graduating from medical schools, which are often private institutions. In Germany, however, the vast majority of medical universities are tax-funded and, for this reason, free of tuition. Significant differences and surprisingly multiple similarities exist between these two systems, despite one depending on government and the other on private organizations. Germany currently employs an integrated medical curriculum that typically begins right after high school and consists of a 2-year long pre-clinical segment teaching basic sciences and a 4-year clinical segment leading medical students to the practical aspects of medicine. On the other hand, the US education is a two-stage process. After successful completion of a Bachelor's degree in college, an American student goes through a 4-year medical program encompassing 2 years of basic science and 2 years of clinical training. In this review, we will address some of these similarities and major differences.
    Description: Deutschland und die Vereinigten Staaten von Amerika haben beide eine lange Tradition der Naturwissenschaft und medizinischen Exzellenz, die bis weit in das neunzehnte Jahrhundert zurückreicht. Den gleichen Tribut muss man den medizinischen Ausbildungssystemen beider Länder zollen. Trotz zu Beginn bedeutsamer Ähnlichkeiten und gewisser Querinspiration scheinen sich die Wege von der Immatrikulation an einer medizinischen Fakultät bis zum Studienabschluss als Arzt in Deutschland und den USA getrennt zu haben. Um eine Lücke in der Fachliteratur zu schließen, ist das Ziel der Autoren, die beiden Strukturen der medizinischen Ausbildung mittels einer aktuellen Übersichtsschrift darzustellen und deren Unterschiede und Gemeinsamkeiten zu untersuchen. Die neusten medizinischen Publikationen, verbindliche Richtlinien von amtlichen oder offiziellen Organisationen, Artikel in der Presse, aber auch die persönlichen Erfahrungen der Autoren dienen als Quellen für diese Arbeit.Studienkredite von über $200.000 sind nicht selten für Studenten in den USA nach deren Abschluss an einer medizinischen Hochschule, die meist in privatem Eigentum ist. In Deutschland dagegen ist die große Mehrheit der Universitäten mit medizinischen Fakultäten in öffentlicher Hand, aus Steuern finanziert und deshalb frei von Studiengebühren. Signifikante Unterschiede doch auch überraschenderweise eine Reihe von Ähnlichkeiten existieren zwischen den Systemen der zwei Länder, obwohl eines von privaten Einrichtungen und das andere von staatlichen Hochschulen abhängig ist. Deutschland verwendet aktuell ein ganzheitliches medizinisches Curriculum, das klassischerweise direkt nach dem Abitur beginnt und aus zwei Jahren vorklinischer und vier Jahren klinischer Ausbildung besteht, wobei letzteres die Studenten an die praktischen Aspekte der Medizin heranführen soll. Auf der anderen Seite herrscht in den USA ein zweistufiger Ausbildungsprozess. Nach erfolgreichem Erreichen eines Bachelorgrads im College führt der Weg eines amerikanischen Studenten durch ein vierjähriges Medizinstudium, welches aus zwei Jahren Grundlagenlehre und zwei Jahren klinischer Ausbildung besteht. In dieser Überblicksarbeit werden wir uns mit einigen dieser Gemeinsamkeiten und Hauptunterschiede befassen.
    Keywords: medical school ; education ; physician ; Germany ; United States ; Medizinstudium ; Ausbildung ; Arzt ; Deutschland ; USA ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Call number: WM270:9 ; WM270:9a
    Keywords: Alcohol Drinking / health aspects ; Alcoholism ; Alcoholism / prevention & control ; Alcoholic Beverages / adverse effects ; Alcoholics / Germany ; DKFZ-publications ; Germany
    Pages: 140 p. : ill.
    ISBN: 9783958533349
    Signatur Availability
    WM270:9 available
    WM270:9a available
    BibTip Others were also interested in ...
  • 9
    Wiesbaden : Statistisches Bundesamt
    Call number: M230:106
    Keywords: Commercial products ; Classification ; Germany
    Pages: xiv, 706 p.
    Edition: Ausgabe 2018
    ISBN: 9783824610587
    Signatur Availability
    M230:106 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 10
    Stuttgart : Deutscher Apotheker-Verlag
    Call number: L801:5/AV
    Keywords: Drugs / chemistry ; Pharmacopoeias ; Quality Control ; Europe ; Germany
    Pages: CD-ROM + 1 booklet
    Edition: 9. Ausg., Grundwerk 2017.
    ISBN: 9783769266795
    Signatur Availability
    L801:5/AV departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 11
    Call number: Q180GG4:23/2017 ; Q180GG4:23/2017a
    Keywords: Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren ; Science ; Research institutes / Evaluation / Germany ; Research ; Germany
    Notes: Title on cover.
    Pages: 51 p. : ill.
    Edition: Developments from 2016 to 1 September 2017
    Signatur Availability
    Q180GG4:23/2017 available
    Q180GG4:23/2017a available
    BibTip Others were also interested in ...
  • 12
    Call number: QZ201:285
    Keywords: Lung Neoplasms / popular works ; DKFZ-publications ; Germany
    Notes: Title on cover
    Pages: 88 p. : ill.
    Signatur Availability
    QZ201:285 available
    BibTip Others were also interested in ...
  • 13
    Call number: Q180GG4:34
    Keywords: Research ; Großforschungseinrichtung ; Germany
    Pages: 153 p.
    ISBN: 9783935353809
    Signatur Availability
    Q180GG4:34 available
    BibTip Others were also interested in ...
  • 14
    Call number: ZZ2017:2/2016
    Keywords: Information Services / popular works ; Research institutes / Evaluation / Germany ; Neoplasms ; DKFZ-publications ; Germany
    Notes: Title on cover.
    Pages: 30 p. : ill.
    Signatur Availability
    ZZ2017:2/2016 available
    BibTip Others were also interested in ...
  • 15
    Call number: G260:27
    Keywords: Drug Utilization / trends ; Germany
    Pages: xiii, 872 p.
    ISBN: 9783662503508
    Signatur Availability
    G260:27 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 16
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS German Medical Science; VOL: 14; DOC03 /20160303/
    Publication Date: 2016-03-04
    Description: Aims: To evaluate the prevalence of chronic diseases (CDs) among older patients in German general practices (GPs).Methods: A total of 840,319 patients older than 65 years (359,289 male and 481,030 female) who consulted a GP between January and December 2014 were selected. Ten different CDs were considered: hypertension, lipid metabolism, diabetes, coronary heart disease, cancer, chronic obstructive pulmonary disease, heart failure, stroke, chronic kidney disease and osteoporosis. The prevalence, defined as the proportion of patients diagnosed with these disorders, was estimated. Results: All CDs were very common in older subjects. Hypertension was the most common CD, affecting 65.7% of men and 66.1% of women. Stroke was the least frequent CD, with 6.6% of men and 5.1% of women displaying this condition. More than one out of two subjects had between one and three CDs (men: 57.7% and women: 59.3%). Approximately 25% of subjects had four or more CDs (men: 26.6% and women: 23.6%).Conclusions: Our study showed that the prevalence of CDs is high in the German elderly population. Hypertension was the most frequent chronic condition and around 25% of patients displayed at least four CDs.
    Description: Hintergrund: Das Ziel dieser Studie ist es, die Häufigkeit von chronischen Erkrankungen bei älteren Patienten in deutschen hausärztlichen Praxen zu ermitteln.Methoden: Es wurden insgesamt 840.319 Patienten im Alter über 65 Jahre (359.289 Männer und 481.030 Frauen) mit mindestens einer Visite beim Hausarzt zwischen Januar und Dezember 2014 identifiziert. Zehn unterschiedliche chronische Erkrankungen wurden untersucht: Hypertonie, Hyperlipidämie, Diabetes, koronare Herzkrankheit (KHK), Krebs, chronisch obstruktive Lungenerkrankung (COPD), Herzinsuffizienz, Schlaganfall, Niereninsuffizienz und Osteoporose. Prävalenz wurde definiert als der Anteil der Patienten mit der jeweiligen Diagnose. Ergebnisse: Alle untersuchten Diagnosen waren häufig bei älteren Patienten. Am häufigsten wurde die Hypertonie diagnostiziert (65,7% der Männer und 66,1% der Frauen). Am seltensten war die Schlaganfall-Diagnose (6,6% der Männer und 5,1% der Frauen). 57,7% der Männer und 59,3% der Frauen hatten zwischen zwei und drei unterschiedliche chronische Erkrankungen; ca. 25% hatten vier oder mehr der untersuchten Diagnosen.Schlussfolgerungen: In dieser Studie konnte eine hohe Prävalenz der chronischen Erkrankungen bei älteren Patienten gezeigt werden. Dabei wurde Hypertonie am häufigsten diagnostiziert und ca. 25% hatten mindestens vier der untersuchten Erkrankungen.
    Keywords: prevalence of chronic diseases ; older patients ; Germany ; Prävalenz ; chronische Erkrankungen ; ältere Patienten ; Deutschland ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 17
    Publication Date: 2016-10-04
    Description: Given the rapidly changing landscape of antimicrobial resistance, continuous monitoring of antimicrobial susceptibility in clinically relevant bacterial isolates plays an important role in the management of infectious diseases. The Tigecycline Evaluation and Surveillance Trial (TEST) is an ongoing worldwide surveillance programme monitoring the in vitro activity of tigecycline and a panel of representative comparator antibiotics. We report longitudinal susceptibility data on a large set of isolates (n=36,044) from clinically significant bacterial species collected in 25 microbiological laboratories from 2006 to 2014. Trends include a strong increase of carbapenem and levofloxacin resistance in Acinetobacter spp., and smaller increasing rates of ESBL-producing Escherichia coli and vancomycin-resistant enterococci. Across the reporting period, the tigecycline minimum inhibitory concentrations (MICs) at which 50% and 90% of isolates were inhibited remained stable and susceptibility rates were consistently high (93-100%) for all bacterial species.
    Keywords: tigecycline ; antimicrobial susceptibility ; multidrug resistance ; Tigecycline Evaluation and Surveillance Trial (TEST) ; Germany ; extended-spectrum beta-lactamase ; methicillin-resistant Staphylococcus aureus ; vancomycin-resistant enterococci ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 18
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  3rd International Meeting of the German Association of Midwifery Science (DGHWi); 20160212-20160212; Fulda; DOC16dghwiP13 /20160205/
    Publication Date: 2016-02-06
    Keywords: stillbirth ; Germany ; quality of care ; bereavement care ; Totgeburt ; Deutschland ; Betreuung ; Begleitung ; ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 19
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 11; DOC21 /20161005/
    Publication Date: 2016-10-05
    Description: Background: Data on MRSA prevalence in rehabilitation centers are sparse.Methods: We screened more than 18,000 patients with neurological, cardiac/pulmonary or orthopedic diagnoses treated in three German rehabilitation centers and documented potential risk factors in almost 1,500 of them.Results: 2.1% were MRSA positive (CI 1.9%-2.4%). Prevalence was higher in neurologic patients (3.7%) and lower in orthopedic patients (0.9%). While the overall MRSA situation was stable over two years, the weekly MRSA rate fluctuated strongly (0.0% to 8.0%). We confirmed five risk factors in our study population. A risk adapted screening strategy derived from our data had a significance of 74% and a positive predictive value of only 2.2%.Conclusion: MRSA positivity is a rare and highly variable event, requiring a huge sample size to generate robust data. The benefit of a risk-adapted screening strategy over a general screening should be questioned in each individual setting.
    Description: Hintergrund: Es liegen nur wenige repräsentative Daten zur MRSA-Prävalenz in Rehabilitationseinrichtungen vor. Methode: Wir untersuchten mehr als 18.000 Patienten mit neurologischen, kardial/pulmonalen oder orthopädischen Diagnosen, die in drei deutschen Rehabilitationseinrichtungen behandelt wurden, und dokumentierten bei 1.500 Patienten mögliche Risikofaktoren.Ergebnisse: 2,1% waren MRSA positiv (KI 1,9%-2,4%). Die Prävalenz war bei neurologischen Patienten höher (3,7%) und niedriger bei orthopädischen Patienten (0,9%). Während die Gesamt-MRSA-Prävalenz über den beobachteten Zweijahreszeitraum stabil war, schwankte die wöchentliche MRSA-Rate stark (0,0%-8,0%). Wir identifizierten fünf Risikofaktoren in unserer Studienpopulation. Ein aus diesen Daten abgeleitetes risikoadaptiertes Screening hatte eine Signifikanz von 74%, aber einen positiven prädiktiven Wert von nur 2,2%.Fazit: Da der MRSA-Nachweis selten und sehr variabel ist, ist ein großer Stichprobenumfang notwendig, um robuste Daten zu generieren. Der Vorteil eines risikoadaptierten Screenings gegenüber einem generellen Screening sollte in jeder individuellen Situation hinterfragt werden.
    Keywords: MRSA ; prevalence ; rehabilitation ; Germany ; MRSA ; Prävalenz ; Rehabilitation ; Deutschland ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 20
    Publication Date: 2016-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boiani, Michele -- Buehler, Alexandra -- England -- Nature. 2016 Mar 31;531(7596):580. doi: 10.1038/531580d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Molecular Biomedicine, Munster, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27029267" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/legislation & jurisprudence/standards ; Animal Welfare/*economics/*legislation & jurisprudence ; Animals ; European Union ; Germany ; Research/*economics/*legislation & jurisprudence ; Research Personnel/*economics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 21
    facet.materialart.
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Curry, Andrew -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1384-9. doi: 10.1126/science.351.6280.1384.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013711" target="_blank"〉PubMed〈/a〉
    Keywords: Bone and Bones/*injuries ; Germany ; History, Ancient ; Humans ; Military Personnel/*history ; Oceans and Seas ; Rivers ; Skull/injuries ; Violence/*history ; *Warfare ; Weapons/*history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 22
    Publication Date: 2016-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2016 Apr 28;532(7600):432-4. doi: 10.1038/532432a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27121823" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Austria ; Bacteria/genetics ; CRISPR-Cas Systems/*genetics ; France ; Genetic Engineering/*history ; Genetic Therapy/history ; Germany ; History, 20th Century ; History, 21st Century ; Microbiology/history ; New York City ; Patents as Topic ; Sweden
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 23
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2016-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wald, Chelsea -- England -- Nature. 2016 May 5;533(7601):S30-1. doi: 10.1038/533S30a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27144606" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*economics/history/*organization & administration ; Entrepreneurship/*economics/history/*organization & administration/trends ; Germany ; History, 20th Century ; History, 21st Century ; Investments/economics/statistics & numerical data/trends ; Licensure/economics ; Politics ; Research/*economics/organization & administration ; Research Personnel/economics ; Technology Transfer ; Universities/economics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 24
    Publication Date: 2016-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiermeier, Quirin -- England -- Nature. 2016 Feb 4;530(7588):18-9. doi: 10.1038/530018a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842038" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics/standards ; Germany ; Physics/organization & administration/standards ; Research/economics/manpower/*organization & administration/*standards ; Research Personnel ; Research Support as Topic ; Universities/economics/standards
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 25
    Call number: QZ203GG4:17/2012-2013/Sachsen
    Keywords: Neoplasms / mortality ; Neoplasms / epidemiology ; Registries ; Germany
    Pages: 71 p. : ill.
    Edition: Registrierungsstand: 30.09.2016
    Signatur Availability
    QZ203GG4:17/2012-2013/Sachsen available
    BibTip Others were also interested in ...
  • 26
    Call number: QZ203GG4:17/2012-2013/Sachs-Anh
    Keywords: Neoplasms / mortality ; Neoplasms / epidemiology ; Registries ; Germany
    Pages: 67 p. : ill.
    Edition: Registrierungsstand: 30.09.2016
    Signatur Availability
    QZ203GG4:17/2012-2013/Sachs-Anh available
    BibTip Others were also interested in ...
  • 27
    Call number: QZ203GG4:17/2012-2013/Brandenb
    Keywords: Neoplasms / mortality ; Neoplasms / epidemiology ; Registries ; Germany
    Pages: 75 p. : ill.
    Edition: Registrierungsstand: 30.09.2016
    Signatur Availability
    QZ203GG4:17/2012-2013/Brandenb available
    BibTip Others were also interested in ...
  • 28
    Call number: QZ203GG4:17/2012-2013/Thuer
    Keywords: Neoplasms / mortality ; Neoplasms / epidemiology ; Registries ; Germany
    Pages: 80 p. : ill.
    Edition: Registrierungsstand: 30.09.2016
    Signatur Availability
    QZ203GG4:17/2012-2013/Thuer available
    BibTip Others were also interested in ...
  • 29
    Call number: ZZ2013:1/2016a ; ZZ2013:1/2016/Mag
    Keywords: Deutsches Krebsforschungszentrum Heidelberg ; Medical Oncology ; Research ; DKFZ-publications ; Germany
    Notes: Titel on cover
    Pages: 167 p. : ill.
    Signatur Availability
    ZZ2013:1/2016a available
    ZZ2013:1/2016/Mag available
    BibTip Others were also interested in ...
  • 30
    Call number: ALLG-BIOGR-DD85:1/26
    Keywords: Germany
    Notes: Includes indexes.
    Pages: xxviii, 852 p.
    ISBN: 9783428001811
    Signatur Availability
    ALLG-BIOGR-DD85:1/26 available
    BibTip Others were also interested in ...
  • 31
    Call number: QZ203GG4:17/2012-2013/Meck
    Keywords: Neoplasms / mortality ; Neoplasms / epidemiology ; Registries ; Germany
    Pages: 64 p. : ill.
    Edition: Registrierungsstand: 30.09.2016
    Signatur Availability
    QZ203GG4:17/2012-2013/Meck available
    BibTip Others were also interested in ...
  • 32
    Call number: G260:16
    Keywords: Drug Utilization / trends ; Germany
    Pages: xiii, 852 p.
    ISBN: 9783662503508
    Signatur Availability
    G260:16 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 33
    Call number: G260:17
    Keywords: Drug utilization ; Costs and Cost Analysis ; Germany
    Pages: x, 125 p.
    ISBN: 9783954662883
    Signatur Availability
    G260:17 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 34
    Call number: ZZ2016:1/Mag
    Keywords: Neoplasms ; International Cooperation ; Academies and Institutes ; DKFZ-publications ; Germany ; Israel
    Pages: 28 p. : ill.
    Signatur Availability
    ZZ2016:1/Mag available
    BibTip Others were also interested in ...
  • 35
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMDS 2015; 60. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20150906-20150909; Krefeld; DOCAbstr. 231 /20150827/
    Publication Date: 2015-08-28
    Keywords: Austria ; Diffusion of Innovation ; Hospital Information Systems ; Nursing Informatics ; Questionaires ; Germany ; ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 36
    Publication Date: 2015-11-16
    Description: In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the "Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care". Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade "A" (strong recommendation), Grade "B" (recommendation) and Grade "0" (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine.
    Description: Die vorherige Version der S3-Leitlinie "Analgesie, Sedierung und Delirmanagement in der Intensivmedizin" wurde 2010 unter der Federführung der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI) publiziert. Neue Evidenz aus Studien ebenso wie neue Leitlinien, u.a. die 2013 erschienene Leitlinie der U.S.-amerikanischen Society of Critical Care Medicine (SCCM), des American College of Critical Care Medicine (ACCM) und der American Society of Health-System Pharmacists (ASHP), gaben nicht nur Anlass zu einem Update der deutschen Empfehlungen von 2010. Für die Fortschreibung der S3-Leitlinie wurden eine Neuformulierung von klinisch relevanten Schlüsselfragen und die signifikante Erweiterung der Leitlinie um neue Facetten der Behandlung, wie zum Beispiel das Schlafmanagement, notwendig. Dazu wurde die systematisch gesuchte Literatur nach Kriterien des Oxford Centre of Evidence Based Medicine bewertet. Der enorme Evidenzkörper bildete die Grundlage für die Empfehlungen, die von Mandatsträgern aus 17 Fachgesellschaften konsentiert wurden. In den Empfehlungen wurden die Grade "A" (starke Empfehlung), "B" (Empfehlung) und "0" (offene Empfehlung) gewählt. Als Ergebnis dieses Prozesses liegt nun die weltweit umfassendste, interdisziplinär erarbeitete evidenz- und konsensbasierte Stufe 3 Leitlinie vor. Die Leitlinie richtet sich an alle auf der Intensivstation tätigen Berufsgruppen, die Empfehlungen berücksichtigen alle intensivmedizinisch-behandelten Patientengruppen. Sie stellt einen Leitfaden zur symptomorientierten Prävention, Diagnostik und Therapie von Delir, Angst, Stress und der protokollbasierten Analgesie, Sedierung und dem Schlafmanagement in der Intensivmedizin für Erwachsene und Kinder dar.
    Keywords: guideline ; evidence ; analgesia ; sedation ; delirium ; anxiety ; stress ; sleep ; monitoring ; treatment ; intensive care ; critical care ; Germany ; Leitlinie ; Analgesie ; Sedierung ; Delir ; Angst ; Stress ; Schlaf ; Monitoring ; Therapie ; Intensivmedizin ; ddc: 610
    Language: English
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 37
    Keywords: Germany ; RISK ; COLORECTAL-CANCER ; VALIDITY ; PREDICTORS ; INEQUALITIES ; PROGRAM ; ENGLAND ; CANCER SCREENING PARTICIPATION
    Abstract: We aimed to describe the utilization of colonoscopy and its association with sociodemographic characteristics within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort study. We included 15 014 study participants (43% men) of the EPIC-Heidelberg cohort recruited between 1994 and 1998. At baseline recruitment, as well as in the 3-yearly follow-up surveys, study participants completed questionnaires on lifestyle, socioeconomic background variables, health status, and use of medications and medical services, including colonoscopy examinations. The present analyses focused on participants who completed the question on colonoscopy examination in all follow-up rounds. Our results show that by the end of the fourth follow-up round, more than half of all participants of the EPIC-Heidelberg cohort had had a colonoscopy. Colonoscopy was associated with some socioeconomic and demographic characteristics: a positive association with vocational training level as well as overall socioeconomic status level [International Standard Classification of Education (ISCED) classification]. A negative association was found for household size and employment status. Colonoscopy usage increased steeply within the subgroup of participants older than 55 years of age and decreased again within the subgroup of participants older than 75 years of age. Organized colorectal cancer screening should include a written invitation system, to overcome the problem of sociodemographic-related differential awareness of and attendance at colonoscopy examinations. Also, the high proportion of prescreened individuals should be taken into account to avoid unnecessary re-examinations.
    Type of Publication: Journal article published
    PubMed ID: 25244156
    Signatur Availability
    BibTip Others were also interested in ...
  • 38
    Keywords: Germany ; TOOL ; TRIAL ; education ; ADULTS ; ERRORS ; COMMUNICATION ; ADHERENCE ; knowledge
    Abstract: We investigated the prevalence and quality of medication schedules of elderly ambulatory patients and assessed factors associated with the availability of a medication schedule. In particular, we evaluated whether sending out a blank medication schedule template would increase the chances to use such a document. Data originate from the ESTHER study, a cohort study conducted in Saarland, Germany, in which trained study physicians performed home visits. They scanned all medication schedules, recorded the participants' medication, and performed thorough geriatric assessments. As part of the intervention, a blank medication schedule template along with a brochure was mailed to half of the participants (intervention group) 4 weeks prior to the home visits. In total, 553 of 2470 participants (22.4 %) had a medication schedule. Almost two thirds of the schedules were issued by health care professionals (n = 353, 63.8 %). These schedules offered a higher quality, although important information such as over-the-counter (OTC) medication was regularly missing. Self-reported adherence was higher in participants who used self-issued medication schedules; however, self-reported medication adherence in patients with any medication schedule was poorer compared to those patients not using a schedule. Factors associated with the availability of a medication schedule were male sex, a higher number of medicines to take, and a more complex drug regimen. The intervention did not increase the number of patients having a medication schedule. Only a minority of elderly ambulatory patients had a medication schedule at home. Sending out a brochure along with a blank medication schedule template did not increase the prevalence of medication schedules.
    Type of Publication: Journal article published
    PubMed ID: 26105963
    Signatur Availability
    BibTip Others were also interested in ...
  • 39
    Keywords: Germany ; DISEASE ; BLOOD-PRESSURE ; TRENDS ; MANAGEMENT ; CARDIOVASCULAR RISK-FACTORS ; EUROPEAN COUNTRIES ; UNITED-STATES ADULTS ; MONICA PROJECT ; AWARENESS
    Abstract: Hypertension is a leading cause of cardiovascular disease. There are very few studies dealing with the incidence of hypertension and changes in blood pressure (BP) over time. We aimed to evaluate the prevalence and incidence of hypertension within an adult population-based cohort.The sample included 967 men and 812 women aged 45 to 83 years at baseline, 1436 subjects completed follow-up1 after 4 years and 1079 completed follow-up2 after 9 years. BP was measured according to a standardized protocol with oscillometric devices and hypertension was defined as mean systolic BP (SBP) 〉/=140 mmHg and/or diastolic BP (DBP) 〉/=90 mmHg and/or use of antihypertensive medication if hypertension was known. We examined prevalence and incidence of hypertension, by age and sex.The age-standardized prevalence of hypertension at baseline was 74.3% for men and 70.2% for women. The age-standardized annual incidence rate of hypertension for men was 8.6 (95% confidence interval [95% CI] 4.3-12.9) for follow-up period1 and 5.4 (95% CI 2.8-10.6) for follow-up period2 and for women 8.2 (95% CI 3.6-12.8) for follow-up1 and 5.6 (95%CI 2.7-11.4) for follow-up2. A clear decrease in SBP and DBP between baseline and follow-up1 and follow-up2 was seen, accompanied by an increase in anti-hypertensive medication consumption and a higher awareness of the condition.Hypertension prevalence and incidence in the CARLA Study appear to be elevated compared with other studies. The decrease of BP over time seems to be caused by improved hypertension control due to interventional effects of our observational study and improved health care.
    Type of Publication: Journal article published
    PubMed ID: 26039136
    Signatur Availability
    BibTip Others were also interested in ...
  • 40
    Keywords: Germany ; signal transduction ; HUMANS ; gene amplification ; ADULT ; DISEASE PROGRESSION ; female ; Male ; Aged ; Middle Aged ; Time Factors ; Proportional Hazards Models ; treatment outcome ; Gene Dosage ; Disease-Free Survival ; Adenocarcinoma/*drug therapy/enzymology/genetics/mortality/pathology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use ; Deoxycytidine/administration & dosage/analogs & derivatives ; Drug Administration Schedule ; Esophageal Neoplasms/*drug therapy/enzymology/mortality/pathology ; Fluorouracil/administration & dosage/analogs & derivatives ; Kaplan-Meier Estimate ; Protein Kinase Inhibitors/administration & dosage/adverse effects/*therapeutic ; use ; Quinazolines/administration & dosage/adverse effects/*therapeutic use ; Receptor, ErbB-2/*antagonists & inhibitors/genetics/metabolism ; Stomach Neoplasms/*drug therapy/enzymology/genetics/mortality/pathology
    Abstract: INTRODUCTION: Human epidermal growth factor receptor 2 (HER2) amplification is present in a subgroup of gastroo-esophageal cancers (GCs). HER2 inhibition with trastuzumab has shown to improve outcomes in advanced disease. Lapatinib ditosylate (LAP), a dual anti-epidermal growth factor receptor (EGFR) and anti-HER2 tyrosine kinase inhibitor with preclinical activity against GC, has been approved in HER2-positive breast cancer. We aimed to study the activity of LAP in HER2-amplified GC. MATERIALS AND METHODS: Patients (pts) with HER2-positive (gene amplification or increased copy numbers based on predefined criteria) advanced GC were randomly allocated 1:1 to receive LAP 1250mg per day 1-21 plus capecitabine (CAP) 2000mg/m(2) on days 1-14 of a 21-day cycle or LAP 1500mg monotherapy day 1-21 after having failed on a platinum-based first-line therapy. HER2 status was assessed centrally. The primary end-point was the objective response rate (ORR) as assessed by the investigator using Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1). We aimed to include 38 pts per arm to show an interesting response rate of 20% in either of the two arms. RESULTS: 37 pts were enrolled (18 to LAP+CAP, 19 to LAP). Pts had received a median of three prior treatment lines. 12 pts in the LAP+CAP group (67%) and 12 pts in the LAP group (63%) had received prior trastuzumab. Only two pts (11.1%; 95% confidence interval (CI): 1.37-34.7), both in the LAP+CAP arm, achieved an objective response. The study was closed prematurely for futility. Median time to progression was 42 (95% CI: 38-61) days in the LAP group and 83 (95% CI: 42-86) days in the LAP+CAP group. Other secondary efficacy end-points (progression-free and overall survival) were comparable in the two treatment groups. Rates of diarrhoea were higher with LAP+CAP (61%; 95% CI: 35-83) compared to 26% (95% CI 9-51) with LAP mono, whereas other adverse events were mostly similar between the groups (18 [100%] versus 17 [90%]). DISCUSSION: Lapatinib showed insufficient activity in HER2-amplified pretreated advanced GC. The safety profile of LAP or LAP+CAP was as expected with some more toxicity in the combination arm. (ClinicalTrials.gov Identifier, NCT01145404).
    Type of Publication: Journal article published
    PubMed ID: 25694417
    Signatur Availability
    BibTip Others were also interested in ...
  • 41
    Keywords: Germany ; EPIDEMIOLOGY ; EXPOSURE ; smoking ; ALCOHOL ; RISK-FACTOR
    Abstract: Prior studies suggest that history of allergy and infections early in life might be inversely associated with cancer. We explored the association between allergies, recent influenza infections and laryngeal cancer risk. We used data from a case-control study which included 229 cases of laryngeal cancer and 769 population controls matched for age and sex. History of a physician-diagnosed allergy, influenza-like infections in the past 5 years, smoking, alcohol consumption and occupational exposure to carcinogens were self-reported. Allergies were classified into two groups (Type I and Type IV), according to the underlying immunologic mechanism. Conditional logistic regression models were fitted using laryngeal cancer as the outcome, adjusting for smoking, alcohol consumption and occupational exposure and stratified for age and sex. Having any allergy was not associated significantly with laryngeal cancer. Although Type I and Type IV allergies were non-significantly associated with laryngeal cancer, Type IV allergies showed a strong inverse association after adjusting for smoking and alcohol (OR 0.50, 95 % CI 0.22-1.2). Participants who reported at least one influenza-like infection during the past 5 years were significantly less likely to have laryngeal cancer (OR 0.57, 95 % CI 0.39-0.81). After considering fever (〉/=38.5 degrees C) as a criterion for influenza infection, the association between influenza infection and laryngeal cancer was even stronger (OR 0.29, 95 % CI 0.13-0.63). We found no significant association between any allergy and laryngeal cancer, some indication of an inverse association between Type IV allergy and laryngeal cancer, whereas recent influenza infections were inversely associated with laryngeal cancer risk.
    Type of Publication: Journal article published
    PubMed ID: 25634066
    Signatur Availability
    BibTip Others were also interested in ...
  • 42
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2015-10-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Oct 1;526(7571):5. doi: 10.1038/526005a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26432201" target="_blank"〉PubMed〈/a〉
    Keywords: Automobiles/*standards ; Environmental Monitoring/economics/*legislation & jurisprudence ; Fraud/*legislation & jurisprudence ; Germany ; United States ; United States Environmental Protection Agency/economics/*legislation & ; jurisprudence/standards ; Vehicle Emissions/*analysis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 43
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2015-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 May 14;521(7551):125-6. doi: 10.1038/521125b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25971468" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/*legislation & jurisprudence ; Animal Welfare/*legislation & jurisprudence/standards ; Animals ; *European Union ; Germany ; Humans ; Models, Animal ; Primates ; Research Personnel
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 44
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2015-03-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2015 Mar 26;519(7544):397-8. doi: 10.1038/519397a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25810182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Autopsy ; Case-Control Studies ; Diabetes Mellitus/*genetics/*pathology/veterinary ; *Disease Models, Animal ; Female ; Genetic Engineering ; Germany ; Humans ; Male ; Mice ; Sus scrofa/*genetics ; *Tissue Banks
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 45
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2015-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Dec 17;528(7582):308. doi: 10.1038/528308a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26672519" target="_blank"〉PubMed〈/a〉
    Keywords: Emigration and Immigration/*legislation & jurisprudence/statistics & numerical ; data ; Germany ; Refugees/*legislation & jurisprudence/statistics & numerical data ; Science/education/manpower ; Transients and Migrants/*legislation & jurisprudence/statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 46
    Publication Date: 2015-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haunschild, Robin -- Bornmann, Lutz -- England -- Nature. 2015 Jan 1;517(7532):21. doi: 10.1038/517021d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Solid State Research, Stuttgart, Germany. ; Max Planck Society, Munich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25557707" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/standards/statistics & numerical data ; *Bibliometrics ; Germany ; *Internationality ; Periodicals as Topic/*standards/statistics & numerical data ; Reproducibility of Results ; Research/*standards/*statistics & numerical data ; Research Report/standards
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 47
    Publication Date: 2015-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, Min-Liang -- England -- Nature. 2015 Aug 27;524(7566):415. doi: 10.1038/524415d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Chung-Hsing University, Taiwan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26310758" target="_blank"〉PubMed〈/a〉
    Keywords: *Death ; Germany ; Great Britain ; History, 20th Century ; Physics/*history/*manpower ; Public Policy/*history ; Research Personnel/*history ; *World War I
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 48
    Publication Date: 2015-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tollefson, Jeff -- England -- Nature. 2015 May 28;521(7553):404-5. doi: 10.1038/521404a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26017423" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Dioxide/*analysis ; Congresses as Topic ; Developed Countries/economics ; Developing Countries/economics ; *Evaluation Studies as Topic ; Germany ; Global Warming/*prevention & control ; *International Cooperation ; Paris ; Research Personnel
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 49
    Publication Date: 2015-06-25
    Description: The origin and early evolution of turtles have long been major contentious issues in vertebrate zoology. This is due to conflicting character evidence from molecules and morphology and a lack of transitional fossils from the critical time interval. The approximately 220-million-year-old stem-turtle Odontochelys from China has a partly formed shell and many turtle-like features in its postcranial skeleton. Unlike the 214-million-year-old Proganochelys from Germany and Thailand, it retains marginal teeth and lacks a carapace. Odontochelys is separated by a large temporal gap from the approximately 260-million-year-old Eunotosaurus from South Africa, which has been hypothesized as the earliest stem-turtle. Here we report a new reptile, Pappochelys, that is structurally and chronologically intermediate between Eunotosaurus and Odontochelys and dates from the Middle Triassic period ( approximately 240 million years ago). The three taxa share anteroposteriorly broad trunk ribs that are T-shaped in cross-section and bear sculpturing, elongate dorsal vertebrae, and modified limb girdles. Pappochelys closely resembles Odontochelys in various features of the limb girdles. Unlike Odontochelys, it has a cuirass of robust paired gastralia in place of a plastron. Pappochelys provides new evidence that the plastron partly formed through serial fusion of gastralia. Its skull has small upper and ventrally open lower temporal fenestrae, supporting the hypothesis of diapsid affinities of turtles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schoch, Rainer R -- Sues, Hans-Dieter -- England -- Nature. 2015 Jul 30;523(7562):584-7. doi: 10.1038/nature14472. Epub 2015 Jun 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Staatliches Museum fur Naturkunde Stuttgart, Rosenstein 1, D-70191 Stuttgart, Germany. ; Department of Paleobiology, National Museum of Natural History, MRC 121, PO Box 37012, Washington, District of Columbia 20013-7012, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26106865" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Shells ; Animals ; *Biological Evolution ; *Fossils ; Germany ; Phylogeny ; Skull/anatomy & histology ; Turtles/*anatomy & histology/classification
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 50
    Publication Date: 2015-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macilwain, Colin -- England -- Nature. 2015 Nov 19;527(7578):277. doi: 10.1038/527277a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26581256" target="_blank"〉PubMed〈/a〉
    Keywords: Faculty/standards ; *Freedom ; Germany ; Great Britain ; Scotland ; Students ; United States ; Universities/legislation & jurisprudence/*manpower/*organization & administration
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 51
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2015-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krull, Wilhelm -- England -- Nature. 2015 Feb 12;518(7538):168. doi: 10.1038/518168a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Volkswagen Foundation in Hanover, Germany. He frequently collaborated with Hubert Markl over 30 years.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25673406" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/organization & administration ; Animals ; Germany ; History, 20th Century ; History, 21st Century ; *Leadership ; Research/*organization & administration ; United States ; Universities/organization & administration ; Zoology/*history
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 52
    facet.materialart.
    Nature Publishing Group (NPG)
    Publication Date: 2015-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Jun 11;522(7555):128. doi: 10.1038/522128a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26062474" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Dioxide/*analysis ; Congresses as Topic ; Environmental Policy/*legislation & jurisprudence ; Fossil Fuels/economics/*utilization ; Germany ; Global Warming/economics/*prevention & control ; International Cooperation/*legislation & jurisprudence ; Renewable Energy/legislation & jurisprudence/statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 53
    Publication Date: 2015-03-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schonfelder, Gilbert -- England -- Nature. 2015 Mar 5;519(7541):33. doi: 10.1038/519033d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉BfR, Berlin; and Charite - University Medicine Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25739621" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animal Experimentation/ethics/*standards ; Animal Welfare/ethics/*standards ; Animals ; *Animals, Laboratory ; European Union ; Germany ; Internet
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687