Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: RECEPTOR ; APOPTOSIS ; CELLS ; IN-VIVO ; SYSTEM ; DEATH ; NF-KAPPA-B ; TUMOR-NECROSIS-FACTOR ; mechanisms ; T-CELLS ; MEMORY ; CYTOCHROME-C ; IMMUNE-RESPONSE ; SIGNALING COMPLEX DISC ; DOMAIN-CONTAINING PROTEIN ; DEATH RECEPTORS ; FAMILY MEMBER BIM ; FAS-MEDIATED APOPTOSIS ; INTERLEUKIN-2 RECEPTOR-BETA ; PHENOTYPE CD8(+) CELLS
    Abstract: Apoptosis of activated peripheral T cells during the termination phase of an immune response is critical to maintain T-cell homeostasis. Activated T cells can be removed by two mechanisms: activation-induced cell death (AICD) and death by neglect. AICD is triggered by death receptors, whereas death by neglect is induced by cytokine withdrawal. CD95 (APO-1/Fas) belongs to the subfamily of death receptors and plays a major role in AICD. In this review, we focus on the molecular mechanisms of AICD, in particular those involving the CD95 system. Moreover, we discuss the relative contribution of AICD and death by neglect to terminate a T-cell immune response. In order to become fully activated, T cells require a second signal provided by antigen-presenting cells. We discuss how these costimulatory signals counteract pro-apoptotic signals and, finally, which signals might protect T cells from death to generate a pool of memory T cells
    Type of Publication: Journal article published
    PubMed ID: 12752671
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: PEPTIDE ; CELLS ; Germany ; IN-VIVO ; MOLECULES ; MICE ; COMPLEX ; RESPONSES ; COMPLEXES ; ANTIGEN ; T-CELL ; T-CELLS ; MOLECULE ; IMMUNE-RESPONSES ; RECOGNITION ; NUMBER ; antigen presentation ; PEPTIDES ; MHC CLASS-I ; CD8(+) ; IMMUNE-RESPONSE ; LOADING COMPLEX ; ENDOPLASMIC-RETICULUM ; SURFACE EXPRESSION ; T-cell response ; CROSS-PRESENTATION ; DISULFIDE BOND FORMATION ; review ; RE ; assembly ; TRANSPORTER ; PROTEIN-SYNTHESIS ; endoplasmic reticulum ; CHAPERONE ; EXOGENOUS ANTIGENS ; PEPTIDE-BINDING
    Abstract: Assembly of major histocompatibility complex (MHC) class I molecules in the endoplasmic reticulum is a highly coordinated process that results in abundant class I/peptide complexes at the cell surface for recognition by CD8(+) T cells and natural killer cells. During the assembly process, a number of chaperones and accessory molecules, such as transporter associated with antigen processing, tapasin, ER60, and calreticulin, assist newly synthesized class I molecules to facilitate loading of antigenic peptides and to optimize the repertoire of surface class I/peptide complexes. This review focuses on the relative importance of these accessory molecules for CD8(+) T-cell responses in vivo and discusses reasons that may help explain why some CD8(+) T-cell responses develop normally in mice deficient in components of class I assembly, despite impaired antigen presentation
    Type of Publication: Journal article published
    PubMed ID: 16181328
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...