CaRLO — Cancer Research Library Online

1

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Endocavitary phased array applicator of therapeutic ultrasound with an integrated opposed-solenoid coil for high resolution MRI-guided thermotherapy: an in vivo study

Rata,M. ; Cotton,F. ; Paquet,C. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: MM3 ; therapeutic ; TEMPERATURE ; ACCURATE ; intensity ; HIGH-RESOLUTION ; ultrasound ; GUIDANCE ; MAGNETIC-RESONANCE ; sensitivity ; PERFORMANCE ; PROBE ; VIVO ; IN-VIVO ; tumor ; treatment ; MR ; MRI ; TUMORS ; RESOLUTION

Abstract: High intensity contact ultrasound (HICU) under MRI guidance may provide minimally invasive treatment of endocavitary digestive tumors (colon/rectum). In this study, opposed-solenoid receiver-only coils were integrated into an endoscopic phased array ultrasound probe to offer high resolution MRI guidance of thermotherapy. The improvement of the image quality and temperature monitoring and control using this device has been investigated in- vivo, on a clinical 1.5T. The comparison endocavitary/external standard coils (voxel: 0.88 x 0.88 x 8 mm3) showed a sensitivity gain up to a factor 4, at the limit of the cooling balloon. Infra-millimeter resolution became feasible for fast MR thermometry while providing an excellent SDT. The endoscopic device was actively operated under automatic temperature control, demonstrating accurate performance.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10417

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2

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Comparison of Two Real Time Tracking Methods for a Robotic Assistance System

Rauschenberg,J. ; de Oliveira,A. ; Maier,F. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: TIME ; MARKER ; CONTRAST AGENT ; MR ; COMBINATION ; CANCER ; ALGORITHM ; SYSTEM ; MARKERS ; LOCALIZATION ; EXCHANGE ; MAGNETIC-RESONANCE ; TRACKING ; cancer research ; POSITION ; PRECISION ; phantom

Abstract: Passive markers such as contrast-agent filled spheres provide a cost-effective and reliable method to localize devices in an MR system. In this work two real time methods are evaluated that track the position of a robotic assistance system with passive markers. A fully automatic localization algorithm with sub-pixel precision, a combination of a phase-only cross correlation with a center-of-mass algorithm, is compared to a direct coordinate exchange between robot and MR. Slice positions and orientations are evaluated in a phantom experiment yielding a similar angular precision of about 1.3 Grad for the needle axis.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10418

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3

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Inductively Coupled Coils for Local SNR-Enhancement during MR-guided Prostate Biopsy

Umathum,R. ; Krafft,A. ; de Oliveira,A. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: cancer research ; Data quality ; INTEGRATION ; BIOPSY ; REQUIREMENT ; MAGNETIC-RESONANCE ; MARKERS ; DESIGN ; PROSTATE ; SYSTEM ; CANCER ; MR ; SYSTEMS ; SAMPLE ; SAMPLES ; MARKER

Abstract: MR-guided prostate biopsy procedures need an improved image SNR. MRS metabolic information could further help deciding from which areas samples need to be taken. As MR data quality crucially depends on local SNR, typically endorectal coils are utilized. In commercial needle holders passive markers fill the available space so that integration of a coil becomes difficult. Inductively coupled coils without direct connection to the MR system have significantly smaller space requirements. Two coil designs were examined for their ability to improve the local SNR at or near the biopsy sample area and for possible integration into commercial biopsy systems.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10423

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4

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Maximum sound pressure levels at 7 Tesla - what's all this fuss about?

Schmitter,S. ; Mueller,M. ; Semmler,W. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: TESLA ; imaging sequences ; cancer research ; LEVEL ; PROTOCOL ; MAGNETIC-RESONANCE ; SAFETY ; SYSTEM ; imaging ; CANCER ; SYSTEMS ; SEQUENCES ; MR ; SEQUENCE

Abstract: In this work the acoustic resonances of a 7 T system were examined and the linear dependency of the sound pressure on the gradient amplitude were verified. The protocols of three different, fast imaging sequences were adjusted on the scanners resonances so that they generate a maximum SPL. A maximum SPL value of 112 dB was found for a sinusoidal EPI sequence, which is similar to SPL values of a 1.5 T system. Thus, regarding acoustic safety, the same safety measures can be applied for this specific 7 T MR system as to 1.5 T systems from the same manufacturer.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10421

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5

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Automatic Passive Tracking of an Manually Steerable Instrument Holder for MR-guided Interventions Applied in LITT

Krafft,A. ; Maier,F. ; Zamecnik,P. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: REQUIREMENT ; ACCURATE ; GUIDANCE ; TRACKING ; MAGNETIC-RESONANCE ; MR ; TIME ; PATIENT ; CANCER ; COMBINATION ; Germany ; INTERVENTIONS ; Application ; TIMES ; RANGE ; cancer research

Abstract: The increasing complexity of MR-guided interventions demands high SNR and short image acquisition times. Therefore, a rising number of such procedures is performed in closed-bore MR scanners where patient access is severely restricted. Consequently, safe, accurate, and continuous instrument monitoring and guidance is a mandatory pre-requisite. A combination of an automatic passive tracking technique and a manually steerable instrument holder is proposed to meet the requirements of percutaneous interventions. The setup was tested during LITT as an advanced minimally invasive technique. Our experiments demonstrate the potential of this approach which is suitable for a wide range of interventional applications.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10504

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6

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New Insights into Mouse Brain Maturation as Assessed by 1H MRS at 7 Tesla

Schmitt,B. ; Amara,C. ; von Both,I. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: development ; LEVEL ; METABOLITE ; pathology ; CHILDREN ; INSIGHTS ; MAGNETIC-RESONANCE ; MOUSE ; MOUSE-BRAIN ; MATURATION ; PHENOTYPE ; animals ; DISEASE ; DISEASES ; MICE ; MR ; CANCER ; brain ; MODEL ; MODELS ; INSIGHT ; DIFFERENTIATE ; cancer research

Abstract: In order to differentiate between normal and disease-related effects in studies of animal models of pathologies it is important to have background information about the phenotype of healthy animals. An animal MRS study was performed to obtain further knowledge about the biochemical maturation of the brain of C57Bl/6 mice during postnatal development. The results indicate that functional development continues after postnatal day 21 as changes in brain metabolite levels can be observed beyond this point. This work provides new findings on physiological mouse brain maturation, which can be particularly important for the investigation of metabolic diseases in young mice.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10511

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7

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Contrast Enhanced MRI Signal Dynamics of FUS-induced BBB Opening in Mouse Brain

Krafft,A. ; Jenne,J. ; Maier,F. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: cancer research ; BLOOD-BRAIN-BARRIER ; SHORT-TERM ; therapeutic ; focused ultrasound ; MR contrast agent ; Contrast enhanced MRI ; brain ; CANCER ; THERAPY ; CONTRAST AGENT ; CONTRAST ; DYNAMICS ; COMPLEX ; COMPLEXES ; LONG-TERM ; TOOL ; MR ; MRI ; SIGNAL ; MAGNETIC-RESONANCE ; MOUSE ; MOUSE-BRAIN ; DISRUPTION ; ultrasound ; THERAPIES ; AGENT ; structure ; ENHANCED MRI

Abstract: The blood-brain barrier (BBB) is a cerebral cellular structure which is impenetrable for many therapeutic substances. Focused ultrasound has been demonstrated as a non-invasive tool for local and reversible BBB opening. MRI-guided BBB opening allows precise monitoring of signal changes after BBB disruption. The underlying dynamic processes of BBB opening are complex, and hence therapy control might be complicated. In this study, we compared short-term and long-term MRI signal dynamics of an interstitial and an intravascular MR contrast agent after BBB opening in mouse brain. Our results may help to define criterions for an optimized therapy control.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10503

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8

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BioShuttle for Temozolomide Transport into Prostate Cancer Cells

Pipkorn,R. ; Waldeck,W. ; Didinger,B. ; [et al.]

Peptides 2008 544-545

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Keywords: TRANSPORT ; prostate cancer ; PROSTATE-CANCER ; bioshuttle ; CANCER-CELLS ; temozolomide ; CANCER ; PEPTIDE ; CELL ; CANCER CELLS ; CELLS ; PROSTATE

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10728

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9

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In vivo Fourier Shifted Two-Dimensional Zero-Quantum Coherence 1H NMR Spectroscopy of Glutamate and Glutamine

Snyder,S. ; Schmitter,S. ; Nagel,A. ; [et al.]

Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine -

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Keywords: SPECTROSCOPY ; MAGNETIC-RESONANCE ; FREQUENCIES ; PARAMETERS ; IDENTIFICATION ; NMR ; NMR-SPECTROSCOPY ; MODULATION ; WHOLE-BODY ; SPECTRA ; CANCER ; IN-VIVO ; VIVO ; MR ; RESOLUTION ; TIME ; cancer research ; glutamine ; WELL ; TIMES ; 3

Abstract: Previously, it has been shown that glutamate can be distinguished from glutamine when their zero-quantum coherence (ZQC) modulation frequencies as well as their chemical shift values are used as identification parameters in 2D spectra. However, acquisition times for such spectra exceeded four hours. We now show that by recording 2D spectra, which are undersampled along the ZCQ modulation frequency axis and then applying a Fourier Shift, glutamate can be distinguished from glutamine in 50 minutes. We demonstrate this on a healthy volunteer using a 3 Tesla whole-body MR tomograph and show that there is no loss in resolution.

Type of Publication: Proceeding

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowProceeding.aspx%3fpublishedId=10513

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