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  • Medicine  (1,981)
  • Arbeitsmedizin
  • Rehabilitation
  • Strömungsmechanik
  • Springer  (2,112)
  • Sage Publications  (11)
  • Bundesarbeitsgemeinschaft für Rehabilitation
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  • 1
    Keywords: Human Genetics ; Metabolic Diseases ; Pediatrics ; Medicine ; Human Genetics ; Metabolic Diseases ; Pediatrics ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Normal Growth in PKU Patients Under Low-Protein Diet in a Single-Center Cross-Sectional Study -- Serial Magnetic Resonance Imaging and 1H-Magnetic Resonance Spectroscopy in GABA Transaminase Deficiency: A Case Report.-Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment -- Cognitive and Behavioural Outcomes of Paediatric Liver Transplantation for Ornithine Transcarbamylase Deficiency -- Muscle Weakness, Cardiomyopathy, and L-2-Hydroxyglutaric Aciduria Associated with a Novel Recessive SLC25A4 Mutation -- Pentosan Polysulfate Treatment of Mucopolysaccharidosis Type IIIA Mice -- Serum Amino Acid Profiling in Citrin-Deficient Children Exhibiting Normal Liver Function During the Apparently Healthy Period -- Severe Leukoencephalopathy with Clinical Recovery Caused by Recessive BOLA3 Mutations -- Neonatal Onset Interstitial Lung Disease as a Primary Presenting Manifestation of Mucopolysaccharidosis Type I -- A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients -- Disruption of the Responsible Gene in a Phosphoglucomutase 1 Deficiency Patient by Homozygous Chromosomal Inversion -- Evaluation of Disease Lesions in the Developing Canine MPS IIIA Brain -- Extrapolation of Variant Phase in Mitochondrial Short-Chain Enoyl-CoA Hydratase (ECHS1) Deficiency -- RFT1-CDG: Absence of Epilepsy and Deafness in Two Patients with Novel Pathogenic Variants -- Short-Term Administration of Mycophenolate Is Well-Tolerated in CLN3 Disease (Juvenile Neuronal Ceroid Lipofuscinosis)
    Abstract: JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder
    Pages: VI, 124 p. 35 illus., 20 illus. in color. : online resource.
    ISBN: 9783662586143
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  • 2
    Keywords: Medicine ; Mathematical Statistics ; Biomedicine general ; Statistics and Computing/Statistics Programs ; Springer eBooks
    Description / Table of Contents: Preface -- General Introduction -- Significant and Insignificant Adverse Effect -- Incidence Ratios and Reporting Ratios of Adverse Effects -- Safety Analysis and the Alternative Hypothesis -- Forest Plots of Adverse Effects -- Graphics of Adverse Effects -- Repeated Measures Methods for Testing Adverse Effects -- Benefit Risk Ratios -- Equivalence, Non-inferiority and Superiority Testing of Adverse Effects -- Part II The Analysis of Dependent Adverse Effects -- Independent and Dependent Adverse Effects. Categorical Predictors Assessed as Dependent Adverse Effects. Adverse Effect of the Dependent Type in Crossover Trial -- Confoundings and Interactions Assessed as Dependent Adverse Effects -- Subgroup Characteristics Assessed as Dependent Adverse Effects -- Random Effects Assessed as Dependent Adverse Effects -- Outliers Assessed as Dependent Adverse Effects -- Index
    Abstract: The authors, as professors in statistics at various universities in Europe, are worrried about the poor quality of safety data analysis of clinical trials, despite its importance in drug development and pharmacovigilance. Clinical trials, not adequately addressing safety, are unethical. An effective approach for the purpose is to present summaries of prevalences. In order to estimate the probability, that the differences between treatment and control group did not occur merely by chance, a statistical test can be performed. This pretty crude method has recently be supplemented with better sensitive methodologies, based on machine learning clusters and networks, and multivariate analyses. Another important novelty with safety data analysis is the new insights into hypothesis testing, favoring the alternative hypotheses instead of the null hypotheses. Finally the issue of dependency is addressed. Adverse effects may be either dependent or independent of the main outcome. Dependent adverse effect are dependent not only on the treatment modalities, but also on the outcome of the trials. Random heterogeneities, outliers, confounders, interaction factors are common in clinical trials, and all of them can be considered kinds of adverse effects of the dependent type. Random regressions and analyses of variance, high dimensional clusterings, partial correlations, structural equations models, and other Bayesian methods are helpful for their analysis. The current edition was particularly written for medical and health professionals and students. It provides examples of modern analytic methods so far largely unused. All of the 16 chapters have two core characteristics, first they are for current usage, second they try and tell what readers need to know in order to understand the methods. Step by step analyses are given and self-assessment examples are supplied. Each chapter can be studied as a stand-alone
    Pages: XI, 217 p. 191 illus., 28 illus. in color. : online resource.
    ISBN: 9783030058043
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  • 3
    Keywords: Medicine ; Dentistry ; Molecular Medicine ; Dentistry ; Springer eBooks
    Description / Table of Contents: Micro-dissection and Isolation of Mouse Dental Epithelial Cells of Continuously Growing Mouse Incisors -- Establishment of an Immortalized Mouse Bmp2 Knock--Out Dental Papilla Mesenchymal Cell Line -- Establishment of Stable Cell Lines from Primary Human Dental Pulp Stem Cells -- Isolation of Dental Stem Cell Enriched Populations from Continuously Growing Mouse Incisors -- Application of Cell Lineage Tracing Combined with Immunofluorescence in the Study of Dentogenesis -- Tissue Recombination and Kidney Capsule Transplantation Assays for the Study of Epithelial-mesenchymal Interactions -- Dental Mesenchymal Stem Cells: Dental Pulp Stem Cells, Periodontal Ligament Stem Cells, Apical Papilla Stem Cells, Primary Teeth Stem Cells: Isolation, Characterization and Expansion for Tissue Engineering -- Phenotypic Identification of Dental Pulp Mesenchymal Stem/Stromal Cells Subpopulations with Multiparametric Flow Cytometry -- Dental Pulp Stem Cells: Isolation, Characterization, Expansion and Odontoblast Differentiation for Tissue Engineering -- In vitro Analysis of Intramolecular Signaling Events in PDLSCs using Confocal and TIRF Microscopy -- A Mouse Model to Study Reparative Dentinogenesis -- Multiwalled Carbon Nanotubes for Dental Applications -- Peptide-mediated Biomimetic Regrowth of Human Enamel in situ -- Bioengineering Tooth Bud Constructs using GelMA Hydrogel -- Whole-mount In Situ Hybridization of Mouse Embryos Using DIG-labeled RNA Probes -- In Situ Hybridization on Mouse Paraffin Sections Using DIG-labeled RNA Probes -- Methods for in situ Proteins Visualization in Dental Mineralized Tissues -- In Situ Hibridization in Mineralized Tissues: The Added Value of LNA Probes for RNA Detection -- Immunofluorescence Procedure for Developing Enamel Tissues -- Silver-albumin Tissue Staining Protocol to Visualize Odontogenesis in Whole Embryos -- Isolation of SIBLING Proteins from Bone and Dentin Matrix -- Immunohistochemical Co-localization of Amelogenin and Ameloblastin in Developing Enamel Matrix -- The Expression and Purification of Recombinant Mouse Ameloblastin in e-coli -- Protocols for Studying Formation and Mineralization of Dental Tissues in vivo -- Extraction Protocol for Isolating Dentin Matrix Proteins from Developing Teeth -- Purification of Developing Enamel Matrix Proteins using Preparative SDS PAGE -- Using ImageJ (FIJI) to Analyse and Present X Ray CT Images of Enamel -- Scanning Electron Microscopy (SEM) Methods for Dental Enamel -- Microcomputed Tomography Imaging in Odontogenesis Studies -- Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) for the Examination of Dental Hard Tissues -- Rodent Dental Fluorosis Model--Extraction of Enamel Organ from Rat Incisors -- Three Dimensional Assessment of Crown Size and Eruption Space for Developing Third Molars: Data Collection Techniques Based on Cone-beam Computed Tomography (CBCT) -- Protocols to Study Dental Caries In Vitro: Microbial Caries Models -- In vitro Caries Models for the Assessment of Novel Restorative Materials -- Protocols to Study Dental Caries In Vitro: pH Cycling Models -- In Vivo Rodent Models for Studying Dental Caries and Pulp Disease -- Protocol GenoDENT: Implementation of a New NGS Panel for Molecular Diagnosis of Genetic Disorders with Orodental Involvement -- Protocols for Genetic and Epigenetic Studies of Rare Diseases Affecting Dental Tissues -- Protocols, Methods, and Tools for Genome-wide Association Studies (GWAS) of Dental Traits -- Measurement of Early Childhood Oral Health for Research Purposes: Dental Caries Experience and Developmental Defects of the Enamel in the Primary Dentition -- The Supragingival Biofilm in Early Childhood Caries: Clinical and Laboratory Protocols and Bioinformatics Pipelines Supporting Oral Metagenomics, Metatranscriptomics and Metabolomics Studies of the Oral Microbiome -- Saliva and Gingival Crevicular Fluid (GCF) Collection for Biomarkers Screening
    Abstract: This volume provides methods and approaches to study genetic and environmental regulatory controls on odontogenesis. Chapters guide readers through protocols for isolation and characterization of both epithelial and mesenchymal dental cells, methods on isolation, phenotypic characterization, expansion, differentiation, immunofluorescence, in situ hybridization, immunohistochemistry, imaging protocols, rodent dental fluorosis model, 3D assessment of crown size, dental diseases models, next generation sequencing, genetic and epigenetic studies, genome-wide association studies as well as clinical protocols for measurement of early childhood caries and saliva, and supragingival fluids and biofilm collection and subsequent analyses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Odontogenesis: Methods and Protocols aims to guide researchers towards elucidating the secrets and mysteries of a fascinating and unique organ, the tooth
    Pages: XVIII, 565 p. 152 illus., 135 illus. in color. : online resource.
    ISBN: 9781493990122
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  • 4
    Keywords: Medicine ; Toxicology ; Cell Physiology ; Endocrinology ; Metabolic Diseases ; Molecular Medicine ; Pharmacology/Toxicology ; Cell Physiology ; Endocrinology ; Metabolic Diseases ; Springer eBooks
    Description / Table of Contents: Part 1. Origin of Brown and Beige Adipocytes -- 1. Brown Adipose Tissue Development and Metabolism -- 2. Lessons from Cre-Mice and Indicator Mice -- 3. Aging of Brown and Beige/Brite Adipose Tissue -- 4. Adipogenesis in Primary Cell Culture -- 5. In Vitro Models for Study of Brown Adipocyte Biology -- 6. Brown-Like Adipocyte Progenitors Derived from Human iPS Cells: A New Tool for Anti-obesity Drug Discovery and Cell-Based Therapy? -- 7. Brown Adipose Tissue in Human Infants -- Part 2. Molecular Mechanisms of BAT Function and Signaling -- 8. Evolution of UCP1 -- 9. The Mechanism FA-Dependent H+ Transport by UCP1 -- 10. Role of cAMP and cGMP Signaling in Brown Fat -- 11. Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis -- 12. Regulatory Small and Long Noncoding RNAs in Brite/Brown Adipose Tissue -- 13. Brown Adipokines -- Part 3 Detection of BAT in vivo -- 14. Infrared Thermography -- 15. In Vivo Detection of Human Brown Adipose Tissue During Cold and Exercise by PET/CT -- 16. Techniques and Applications of Magnetic Resonance Imaging for Studying Brown Adipose Tissue Morphometry and Function -- 17. Multispectral Optoacoustic Tomography of Brown Adipose Tissue -- 18. BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity -- Part 4. Recruitment and Activation of human BAT -- 19. Activation of Human Brown Adipose Tissue (BAT): Focus on Nutrition and Eating -- 20. Translational Aspects of Brown Fat Activation by Food-Derived Stimulants -- 21. Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment
    Abstract: The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions
    Pages: VIII, 424 p. 52 illus., 49 illus. in color. : online resource.
    ISBN: 9783030105136
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  • 5
    Unknown
    Singapore : Springer
    Call number: QH324:49
    Keywords: Bioinformatics ; Medicine ; Statistics ; Biomedicine general ; Statistics for Life Sciences, Medicine, Health Sciences
    Description / Table of Contents: Part 1. BIOINFORMATICS FOR LIFE AND PERSONAL GENOME INTERPRETATION -- Chapter 1. Bioinformatics For Life -- Chapter 2. Next Generation Sequencing and Personal Genome Data Analysis -- Chapter 3. Personal Genome Data Analysis -- Chapter 4. Personal Genome Interpretation and Disease Risk Prediction -- Part 2. ADVANCED MICROARRAY DATA ANALYSIS -- Chapter 5. Advanced Microarray Data Analysis -- Chapter 6. Gene Expression Data Analysis -- Chapter 7. Gene Ontology and Biological Pathway-based Analysis -- Chapter 8. Gene-set Approaches and Prognostic Subgroup Prediction -- Chapter 9. MicroRNA Data Analysis -- Part 3. NETWORK BIOLOGY, SEQUENCE, PATHWAY AND ONTOLOGY INFORMATICS -- Chapter 10. Network Biology, Sequence, Pathway and Ontology Informatics -- Chapter 11. Motif and Regulatory Sequence Analysis -- Chapter 12. Molecular Pathways and Gene Ontology -- Chapter 13. Biological Network Analysis -- Part 4. SNPS, GWAS AND CNVS, INFORMATICS FOR GENOME VARIANTS -- Chapter 14. SNPs, GWAS, CNVs: Informatics for Human Genome Variations -- Chapter 15. SNP Data Analysis -- Chapter 16. GWAS Data Analysis -- Chapter 17. CNV Data Analysis -- Part 5. METAGENOME AND EPIGENOME, BASIC DATA ANALYSIS -- Chapter 18. Metagenome and Epigenome Data Analysis -- Chapter 19. Metagenome Data Analysis -- Chapter 20. Epigenome Databases and Tools -- Chapter 21. Epigenome Data Analysis -- Appendix A. BASIC PRACTICE USING R FOR DATA ANALYSIS -- Appendix B. APPLICATION PROGRAM FOR GENOME DATA ANALYSIS INSTALL GUIDE
    Abstract: This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. This textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics
    Pages: xvi, 367 p. : ill.
    ISBN: 9789811319419
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  • 6
    Keywords: Proteomics ; Biochemistry ; Cell Membranes ; Medicine ; Proteomics ; Protein Science ; Membrane Biology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Introduction -- Direct binding of cholesterol to proteins -- Cholesterol-recognition motifs in membrane proteins -- Molecular determinants of cholesterol binding to proteins: overview of crystallographic studies -- Crystallographic studies of steroid-protein interactions -- Insights into cholesterol binding sites in proteins from computational studies -- Cholesterol binding to NPC1/NPC2 -- I Biophysical elements of the interaction between cholesterol and the nicotinic acetylcholine receptor -- Modulation of TRPV1 channels by cholesterol -- Cholesterol binding sites in inwardly rectifying potassium channels
    Abstract: In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems
    Pages: IX, 168 p. 51 illus., 50 illus. in color. : online resource.
    ISBN: 9783030142650
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  • 7
    Keywords: Human Genetics ; Human Physiology ; Neurochemistry ; Medicine ; Biochemistry ; Cardiovascular System ; Human Genetics ; Human Physiology ; Neurochemistry ; Molecular Medicine ; Protein Science ; Cardiovascular Biology ; Springer eBooks
    Description / Table of Contents: Prelims -- Diffusion and transport of reactive species across cell membranes -- Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry. Understanding Peroxisome Proliferator-Activated Receptors: from the structure to the regulatory actions on metabolism -- Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase. Unfolded protein response: Cause or consequence of lipid and lipoprotein metabolism disturbances?- Arachidonic acid metabolism in macrophages: role of NADPH oxidases -- Lipid Metabolism and Signaling in Platelet Function -- Dyslipidemia in ischemia/reperfusion injury -- Epicardial adipose tissue in cardiovascular disease -- Bioactive Lipids and the gut-brain axis: diet as a modulator of bioactivity and diversity of lipids in the brain -- Nitroalkylation of α-synuclein by nitro-oleic acid: Implications for Parkinson´s disease -- Bioactive lipids in inflammation after central nervous system injury -- Index
    Abstract: The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology
    Pages: VIII, 198 p. 41 illus., 35 illus. in color. : online resource.
    ISBN: 9783030114886
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  • 8
    Keywords: Medicine ; Pharmaceutical technology ; Biomedical Engineering ; Diabetes ; Molecular Medicine ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Diabetes ; Springer eBooks
    Description / Table of Contents: Chapter 1. Improvement of HDL -- 1-1.Clinical application of HDL: Overview -- 1-2.Regression effect of V156K-apoA-I -- 1-3.Anti-diabetic effect of V156K-apoA-I -- 1-4.Vitamin C and HDL -- 1-5.Growth hormone-1 in HDL -- 1-6.Growth hormone-2 in HDL -- 1-7.Omega-3 and HDL -- Chapter 2. HDL as therapeutic tools -- 2-1.Delivery vehicle for therapeutics : Overview -- 2-2.Gene delivery: adenovirus and V156K-apoA-I -- 2-3.Solubilization of rapamycin and delivery -- 2-4.Solubilization of minoxidil and delivery -- Chapter 3. Enhancement of HDL by policosanol: anti-aging and longevity -- 3-1.Policosanol and HDL functionality -- 3-2.Policosanol and raising HDL in zebrafish -- 3-3.Policosanol and CETP inhibition: human trial 8 weeks -- 3-4.Policosanol and blood pressure lowering: human trial 8 weeks -- 3-5.Policosanol blood pressure lowering human trial for 24 weeks -- 3-6.Policosanol and improvement of aortic stiffness -- 3-7.Policosanol and blood pressure lowering in rat model -- 3-8.Twelve week consumption of policosanol and lowering blood pressure -- 3-9.Publication analysis of policosanol-related studies -- 3-10.Athero-protective effects of policosanol and sugar cane wax acid -- 3-11.Cuban sugarcane wax acids and policosanol improved serum lipid profiles -- Summary and perspectives -- Epilogue
    Abstract: This book is the second of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. In this volume, the focus is on the improvement of HDL, enhancement of its functionality, and the use of HDL for therapeutic purposes. In the first section, up-to-date information is provided on such topics as the tumor regression-promoting and antidiabetic activities of reconstituted HDL containing V156K apolipoprotein A-I, the enhancement of HDL effects by high doses of vitamin C, the benefits derived from incorporation of growth hormones 1 and 2 into rHDL, and the biological functions of omega-3 linolenic acid in rHDL. The enhancement of HDL functionality by policosanol and the resultant benefits are thoroughly examined in a separate section. Readers will also find the latest information on clinical applications of HDL. Here, specific topics include the enhancement of adenoviral gene delivery and the delivery of rapamycin. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians
    Pages: XVI, 268 p. 174 illus. : online resource.
    ISBN: 9789811373831
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  • 9
    Keywords: Medicine ; Toxicology ; Pharmaceutical technology ; Life sciences ; Biochemistry ; Animal Physiology ; Biomedicine general ; Pharmacology/Toxicology ; Pharmaceutical Sciences/Technology ; Life Sciences, general ; Animal Biochemistry ; Animal Physiology ; Springer Nature Living Reference
    Abstract: This volume provides an overview of microbial toxins from diverse bacterial and fungal origins. These molecules, produced by various species and consisting of protein or small organic molecules, can play a pivotal role in pathogenesis of plants, animals, and humans that in turn can lead to the survival/dissemination of the host microbe. Many of these microbes, due to their toxins, impact our society from a health and economic perspective. In particular, this volume address the diverse niches of these organisms focused upon their associated toxins. The structures, functions, and genetics of toxins will be addressed. Besides the ill-effects elicited by these toxins, it must be noted that there is immense potential for turning some of these harmful molecules into useful tools as specific probes (of receptors), novel drugs or drug-conjugates for the treatment of various diseases, and immunomodulating agents for targeted vaccine delivery for research and unique medicines. Recent progress in bacterial genome mapping and establishment of three-dimensional crystal structures of several bacterial toxins provides a deeper knowledge and greater understanding of structure-function relationships. Moreover, the emergence of some bacteria (i.e., Bacillus anthracis, Burkholderia pseudomallei, Staphylococcus aureus), and their toxins, as biological weapons also necessitates a thorough understanding of these agents, their pathophysiology, and development of countermeasures. This volume will also be a common resource for researchers interested in many other medically-relevant microorganisms, and their toxins, that include Clostridium botulinum, C. difficile, C. perfringens, C. tetani, Escherichia coli, Helicobacter pylori, and Listeria monocytogenes.℗ Recent studies have correlated the effect of global warming and climate change as a trigger for natural disasters and impact on human health via emergence of various vector-borne and infectious diseases caused by toxin-producing microbes. The 2003 Institute of Medicine (IOM) report, ́€œMicrobial Threats to Health,́€ identified the influence of changing ecosystem on the emergence and spread of infectious diseases and economic development of specific regions of the world.℗ This current handbook is a major reference work on microbial toxins written by a panel of International experts and organized into 24 chapters
    Pages: Approx. 550 p. 30 illus., 15 illus. in color. : online resource.
    ISBN: 9789400767256
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  • 10
    Keywords: Medicine ; Toxicology ; Pharmaceutical technology ; Life sciences ; Biochemistry ; Animal Physiology ; Biomedicine general ; Pharmacology/Toxicology ; Pharmaceutical Sciences/Technology ; Life Sciences, general ; Animal Biochemistry ; Animal Physiology ; Springer Nature Living Reference
    Abstract: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively
    Pages: 5400 p. 300 illus., 150 illus. in color. : online resource.
    ISBN: 9789400762886
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  • 11
    Unknown
    Dordrecht : Springer
    Keywords: Medicine ; Life sciences ; Biomedicine general ; Life Sciences, general ; Springer Nature Living Reference
    Abstract: The Encyclopedia of Lipidomics will present a complete overview of the field from fundamentals to new discoveries and from concepts, theories and experimental techniques to clinical and industrial applications. The book will develop with the active involvement of a strong editorial board comprised of leaders from the field. The Encyclopedia of Lipidomics intends to be a comprehensive reference resource serving to bridge the gap between clinical and basic science investigators and provide authoritative and digested information to students, scientists as well as non specialists. The book will have an edge over protocol type of works and databases in terms of having wider coverage through rigorous essays on terms, concepts, experimental and analytical techniques, applications and new challenges. Since lipidomics has strong linkages with several of the other biomedical and life sciences disciplines, the proposed encyclopedia will have a wide audience including graduate students, researchers and different levels of scientists in biomedicine, cellular and molecular biology, bioengineering, physiological and biochemistry, and pharmacology across both academia and industry
    Pages: 4800 p. : online resource.
    ISBN: 9789400778641
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  • 12
    Unknown
    New York, NY : Springer
    Keywords: Oncology ; Oncology   ; Medical laboratories ; Internal Medicine ; Medicine ; Toxicology ; Cancer Research ; Oncology ; Laboratory Medicine ; Internal Medicine ; Molecular Medicine ; Pharmacology/Toxicology ; Springer Nature Living Reference
    Abstract: In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well
    Pages: 800 p. 164 illus., 64 illus. in color. : online resource.
    ISBN: 9781461466130
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  • 13
    Unknown
    New York, NY : Springer
    Keywords: Human Genetics ; Medicine ; Human Genetics ; Cytogenetics ; Molecular Medicine ; Springer Nature Living Reference
    Description / Table of Contents: Acardia -- Achondrogenesis -- Achondroplasia -- Adams-Oliver syndrome -- Agnathia -- Aicardi syndrome -- Alagille syndrome -- Albinism -- Alpha thalassemia-mental retardation (ATR-X) syndrome -- Ambiguous genitalia -- Amniotic deformity, adhesions, mutilations (ADAM) syndrome -- Androgen insensitivity syndrome -- Angelman syndrome -- Apert syndrome -- Aplasia cutis congenita -- Arthrogryposis multiplex congenita -- Asphyxiating thoracic dystrophy -- Ataxia telangiectasia -- Atelosteogenesis -- Autism -- Bannayan-Riley-Ruvalcaba syndrome -- Beckwith-Wiedemann syndrome -- Behcet disease -- Biotinidase deficiency -- Bladder exstrophy -- Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) -- Body stalk anomaly -- Brachydactyly -- Branchial cleft cyst -- Calcinosis cutis -- Campomelic dysplasia -- Carpenter syndrome -- Cat-eye syndrome -- Celiac disease -- Cerebral palsy -- Cerebro-costo-mandibular syndrome -- Charcot-Marie-Tooth disease -- CHARGE association -- Cherubism -- Chiari malformation -- Chondrodysplasia punctata -- Chromosome abnormalities in pediatric solid tumors -- Cleft lip/palate -- Cleidocranial dysplasia -- Cloacal exstrophy -- Clubfoot (talipes equinovarus) -- Collodion baby -- Congenital adrenal hyperplasia -- Congenital cutis laxa -- Congenital cytomegalovirus infection -- Congenital generalized lipodystrophy -- Congenital hemihyperplasia (congenital hemihypertrophy) -- Congenital hydrocephalus -- Congenital hypothyroidism -- Congenital muscular dystrophy -- Congenital toxoplasmosis -- Conjoined twins -- Corpus-callosum agenesis/dysgenesis -- Craniometaphyseal dysplasia -- Cri-du-chat syndrome -- Crouzon syndrome -- Cutis marmorata telangiectatica congenita -- Cystic fibrosis -- Dandy-Walker malformation -- De Lange syndrome -- Del(18p) syndrome -- Del(22q11.2) syndrome -- Del(Yq) syndrome -- Diabetic embryopathy -- Down syndrome -- Duncan syndrome (X-linked lymphoproliferative disease) -- Dyschondrosteosis/Langer mesomelic dysplasia -- Dysmelia (limb deficiency/reduction) -- Dysplasia epiphysealis hemimelica -- Dystonia -- Dystrophinopathies -- EEC syndrome -- Ehlers-Danlos syndrome -- Ellis-van Creveld syndrome -- Enchondromatosis -- Epidermolysis bullosa -- Epidermolytic palmoplantar keratoderma -- Faciogenital (Aarskog) syndrome -- Facioscapulohumeral muscular dystrophy (FSH) -- Familial adenomatous polyposis syndrome -- Familial hyperlysinemia -- Familial Mediterranean fever -- Fanconi anemia -- Femoral hypoplasia-unusual facies syndrome -- Fetal akinesia syndrome -- Fetal alcohol syndrome -- Fetal hydantoin syndrome -- Fibrodysplasia ossificans progressiva -- Finlay-Marks syndrome -- Floppy infant -- Fragile X syndrome -- Fraser syndrome -- Freeman-Sheldon (whistling face) syndrome -- Friedreich ataxia -- Frontonasal dysplasia -- Galactosemia -- Gastroschisis -- Gaucher disease -- Generalized arterial calcification -- Genitopatellar syndrome -- Giant congenital melanocytic nevi (giant congenital nevi) -- Glucose-6-phosphate dehydrogenase deficiency -- Glycogen storage disease, type II (Pompe) -- Goldenhar syndrome -- Gorlin (nevoid basal cell carcinoma) syndrome -- Greig cephalopolysyndactyly syndrome -- Hallermann-Streiff syndrome -- Harlequin fetus -- Hemophilia A -- Hereditary hearing loss -- Hereditary hemochromatosis -- Hereditary multiple exostosis -- Herlyn-Werner-Wunderlich syndrome -- Holoprosencephaly -- Holt-Oram syndrome -- Huntington disease -- Hydrolethalus syndrome -- Hydrops fetalis -- Hyper-IgE syndrome -- Hypochondroplasia -- Hypoglossia-hypodactyly (oromandibular limb hypogenesis) syndrome -- Hypohidrotic ectodermal dysplasia -- Hypomelanosis of Ito -- Hypophosphatasia -- Hypopituitarism -- I(1p),I(1q) syndrome -- Isodic(Yq) syndrome -- Incontinentia pigmenti -- Infantile myofibromatosis -- Ivemark syndrome -- Jarcho-Levin syndrome -- Joubert syndrome -- Kabuki syndrome -- Kassback-Merritt syndrome -- KID syndrome -- Klinefelter syndrome -- Klippel-Feil syndrome -- Klippel-Trenaunay syndrome -- Kniest dysplasia -- Larsen syndrome -- LEOPARD syndrome -- Lesch-Nyhan syndrome -- Lethal multiple pterygium syndrome -- Loeys-Dietz syndrome -- Lowe syndrome -- Marfan syndrome -- McCune-Albright syndrome -- Meckel-Gruber syndrome -- Megalencephalic leukoencephalopathy with subcortical cysts (van der Knaap disease) -- Menkes disease -- Metachromatic leukodystrophy -- Miller-Dieker syndrome -- Mitochondrial Leber hereditary optic neuropathy -- Mobius syndrome -- Mowat-Wilson Disease -- Mucolipidosis II (I-cell disease) -- Mucolipidosis III (pseudo-Hurler Polydystrophy) -- MPS I (Hurler syndrome) -- MPS II (Hunter syndrome) -- MPS III (Sanfilippo syndrome) -- MPS IV (Morquio syndrome) -- MPS VI (Maroteaux-Lamy syndrome) -- Multiple endocrine neoplasia Syndrome -- Multiple epiphyseal dysplasia -- Multiple pterygium syndrome -- Myotonic dystrophy -- Nail-Patella Syndrome (hereditary Osteo-onychodysplasia) -- Neonatal Herpes simplex infection -- Nephrogenic diabetes insipidus -- Netherton syndrome -- Neu-Laxova syndrome -- Neural tube defects -- Neurofibromatosis 1 -- Neurofibromatosis 2 -- Noonan syndrome -- Oblique facial cleft syndrome -- Oligohydramnios sequence -- Omphalocele -- Oro-Facial-Digital Syndrome -- Osteogenesis imperfecta -- Osteopetrosis -- Osteopoikilosis -- Otopalatodigital spectrum disorders -- Pachyonychia congenita -- Pallister-Killian syndrome -- Phenylketonuria (PKU) -- Pierre Robin sequence -- Polycystic kidney disease, AD form -- Polycystic kidney disease, AR form -- Popliteal pterygium syndrome -- Prader-Willi syndrome -- Progeria -- Prune belly syndrome -- Pseudoachondroplasia -- R(18) syndrome -- Retinoid embryopathy -- Rett syndrome -- Rickets -- Rigid spine syndrome -- Roberts syndrome -- Robinow syndrome -- Rubinstein-Taybi syndrome -- Saethre-Chotzen syndrome -- Sagittal synostosis associated with chromosome abnormalities -- Schizencephaly -- Schmid metaphyseal chondrodystrophy -- Seckel syndrome -- Severe combined immune deficiency -- Short rib polydactyly syndromes (SRPS) -- Sickle cell disease -- Silver-Russell syndrome -- Sirenomelia -- Smith-Lemli-Optiz syndrome -- Smith-Magenis syndrome -- Sotos syndrome -- Spinal muscular atrophy -- Spondyloepiphyseal dysplasia -- Stickler syndrome -- Sturge-Weber syndrome -- Tay-Sachs disease -- Tetrasomy 9p syndrome -- Thalassemia -- Thanatophoric dysplasia -- Thrombocytopenia-absent radius (TAR) syndrome -- Treacher-Collins syndrome -- Trimethylaminuria -- Triploidy -- Trismus pseudocamptodactyly (Hecht syndrome) -- Trisomy 8 mosaicism (Warkany) syndrome -- Trisomy 13 syndrome -- Trisomy 18 syndrome -- Tuberous sclerosis -- Turner syndrome -- Twin-twin transfusion syndrome -- Ulnar-mammary syndrome -- Urofacial (Ochoa) Syndrome -- VATER (VACTERL) association -- Von Hippel-Lindau disease -- Waardenburg syndrome -- Weill-Marchesani syndrome -- Williams syndrome -- Wolf-Hirschhorn syndrome -- X-linked agammaglobulinemia (Bruton type) -- X-linked ichthyosis -- XX Male -- XXX syndrome -- XXXXX syndrome -- XXXXY syndrome -- XY female.-XYY syndrome
    Abstract: Dr. Chen shares his almost 40 years of clinical genetics practice in a comprehensive pictorial atlas of almost 250 genetic disorders, malformations, and malformation syndromes. The author provides a detailed outline for each disorder, describing its genetics, basic defects, clinical features, diagnostic tests, and counseling issues, including recurrence risk, prenatal diagnosis, and management. Numerous color photographs of prenatal ultrasounds, imagings, cytogenetics, and postmortem findings illustrate the clinical features of patients at different ages, patients with varying degrees of severity, and the optimal diagnostic strategies. The disorders cited are supplemented by case histories and diagnostic confirmation by cytogenetics, biochemical, and molecular techniques, when available. The Atlas of Genetic Diagnosis and Counseling will help all physicians to understand and recognize genetic diseases and malformation syndromes and better evaluate, counsel, and manage affected patients. In this new edition, 47 additional genetic disorders are added, as well as extensive updates made to the previous disorders. New illustrations, as previous edition, will be supplemented by case and family history, clinical features, and laboratory data, especially molecular confirmation
    Pages: LX, 2224 p. 2472 illus., 2018 illus. in color. : online resource.
    ISBN: 9781461464303
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  • 14
    Keywords: Human Genetics ; Oncology ; Medicine ; Nucleic Acids ; Human Genetics ; Cancer Research ; Molecular Medicine ; Nucleic Acid Chemistry ; Springer eBooks
    Description / Table of Contents: Prelims -- Networks of mRNA processing and alternative splicing regulation in health and disease -- The diverse roles of RNA-binding proteins in glioma development -- Nonsense-mediated mRNA decay in development, stress and cancer -- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes -- Translational regulation by upstream open reading frames and human diseases -- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer -- RNA therapeutics: how far have we gone? Index
    Abstract: The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community
    Pages: IX, 180 p. 18 illus., 17 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030199661
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  • 15
    Keywords: Toxicology ; Human Physiology ; Medicine ; Biochemistry ; Oncology ; Pharmacology/Toxicology ; Human Physiology ; Health Promotion and Disease Prevention ; Biochemistry, general ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Preface -- Chapter I. Introduction -- 1.History of Discovery of Vitamin C -- 2.What is vitamin C? -- 3.Chemical Properties of Vitamin C as Anti-oxidant -- 4.Biological Activities as Co-factors -- 5.Scientific Background of Optimal Dose -- 6.How to take? -- 7.Adverse Effects -- Chapter II. Cardiovascular System -- Chapter III. Cancer -- Chapter IV. Immune system -- Chapter V. Respiratory System, Common Cold and Influenza -- Chapter VI. Central Nervous System -- Chapter VII. Aging -- Chapter VIII. Stress -- Chapter IX. Gastrointestinal (GI) System -- Chapter X. Liver -- Chapter XI. Skin -- Chapter XII. Eye -- Chapter XIII. Summary and Conclusion
    Abstract: This book presents the scientific evidence for the role of vitamin C in health and disease and offers new guidance on vitamin C intake in humans. The importance of vitamin C in preventing cancer and cardiovascular disease, its relevance to aging and stress, and its impacts on each of the human body systems are thoroughly assessed on the basis of the author’s extensive research and his deep understanding, as an anatomy professor, of the body as a whole. Findings published in the international scientific literature are fully taken into account, and due consideration is also given to empirical evidence, bearing in mind that mechanisms of action cannot always be precisely defined in the absence of human experiments. Beyond providing an up-to-date scientific perspective on the effects of vitamin C, the author hopes to promote human health worldwide by encouraging proper use of the vitamin. To this end, recommendations are made on the amount of vitamin C that should be taken daily and on the best way to take it. The book will be of interest to researchers, clinicians, and all others who wish to learn more about this vitamin and its significance
    Pages: IX, 184 p. 72 illus., 62 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789402417135
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  • 16
    Keywords: Aging ; Developmental Biology ; Medicine ; Human Physiology ; Immunology ; Biogerontology ; Molecular Medicine ; Human Physiology ; Immunology ; Springer eBooks
    Description / Table of Contents: Introduction -- Section-1 BIOMARKERS OF AGING AND HEALTH -- Practical Detection of Biological Age: Why it is not a trivial task -- Biological age is a universal marker of aging, stress, and frailty -- Biomarkers of health and healthy ageing from the outside-in -- Biomarkers of aging -- Review of molecular and cellular biomarkers of aging -- Section-2 PROTEOMICS AND GLYCOMICS BIOMARKERS OF AGING -- IgG glycans as a biomarker of biological age -- Oxidatively modified proteins and maintenance systems as biomarkers of aging -- Is impaired proteodynamics a key to understand the biomarkers of cellular aging -- Section-3 GENETICS AND EPIGENETICS AGING MARKERS -- Genetic markers of extreme human longevity -- Epigenetic biomarkers of aging -- DNA methylation biomarkers to assess biological age -- Epigenetics of brain aging: lessons from chemo brain and tumor brain -- Approaches and methods for variant analysis in a cell -- Section 4 IMMUNOSENESCENCE AND INFLAMMAGING MARKERS -- Is there any reliable biomarker for immunosenescence and inflammaging? -- Immune parameters associated with mortality in longitudinal studies of very old people can be markedly dissimilar even in apparently similar populations -- Gut microbiota and aging -- Section-5 SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE AND MORTALITY MARKERS -- Deep integrated biomarkers of aging -- Quantification of the biological age of the brain using -- Arterial aging: the role of hormonal and metabolic status and telomere biology -- Circulating Biomarkers of Aging -- Molecular signature of aging driven by Wnt signaling pathway: Lessons from nematodes -- The problem of integrating of biological and clinical markers of aging -- Index
    Abstract: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the €œépigenetic clock,́€ as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers
    Pages: VII, 421 p. 39 illus., 34 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030249700
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  • 17
    Keywords: Medicine ; Artificial intelligence ; Algorithms ; Biomedicine general ; Artificial intelligence ; Algorithms ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction to Deep Density Models with Latent Variables -- Deep RNN Architecture: Design and Evaluation -- Deep Learning Based Handwritten Chinese Character and Text Recognition -- Deep Learning and Its Applications to Natural Language Processing -- Deep Learning for Natural Language Processing -- Oceanic Data Analysis with Deep Learning Models -- Index
    Abstract: The purpose of this edited volume is to provide a comprehensive overview on the fundamentals of deep learning, introduce the widely-used learning architectures and algorithms, present its latest theoretical progress, discuss the most popular deep learning platforms and data sets, and describe how many deep learning methodologies have brought great breakthroughs in various applications of text, image, video, speech and audio processing. Deep learning (DL) has been widely considered as the next generation of machine learning methodology. DL attracts much attention and also achieves great success in pattern recognition, computer vision, data mining, and knowledge discovery due to its great capability in learning high-level abstract features from vast amount of data. This new book will not only attempt to provide a general roadmap or guidance to the current deep learning methodologies, but also present the challenges and envision new perspectives which may lead to further breakthroughs in this field. This book will serve as a useful reference for senior (undergraduate or graduate) students in computer science, statistics, electrical engineering, as well as others interested in studying or exploring the potential of exploiting deep learning algorithms. It will also be of special interest to researchers in the area of AI, pattern recognition, machine learning and related areas, alongside engineers interested in applying deep learning models in existing or new practical applications
    Pages: VII, 163 p. 66 illus., 46 illus. in color. : online resource.
    ISBN: 9783030060732
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  • 18
    Keywords: Medicine ; Oncology ; Molecular Medicine ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Amplicon-based Targeted Next Generation Sequencing of Formalin Fixed Paraffin Embedded Tissue -- Library preparation using FFPE-derived Tumor DNA for High Throughput Hybridization-based Targeted or Exome Sequencing -- Bioinformatics Basics for High Throughput Hybridization-based Targeted DNA Sequencing From FFPE-Derived Tumor Specimens: From Reads to Variants -- Annotation of Variant Data from High Throughput DNA Sequencing from Tumor Specimens: Filtering Strategies to Identify Driver Mutations -- Biological Interpretation of Complex Genomic Data -- Clinical Validation of Targeted Solid Tumor Profiling -- Whole Genome Single Nucleotide Polymorphism Microarray for Copy Number and Loss of Heterozygosity Analysis in Tumors -- Genome-Wide Copy Number Variation Detection using NGS: Data Analysis and Interpretation -- Overview of Fusion Detection Strategies Using Next Generation Sequencing -- Clinical Application of Fusion Gene Detection Using Next-generation Sequencing and the NanoString Technology -- Pipeline for Integrated Microarray Expression Normalization Toolkit (PIMENTo) for Tumor Microarray Profiling Experiment -- Molecular Profiling of RNA Tumors using High Throughput RNA Sequencing: Overview of Library Preparation Methods -- Molecular Profiling of RNA Tumors using High Throughput RNA Sequencing: From Raw Data to Systems Level Analyses -- Methylation Analysis using Microarrays: Analysis and Interpretation -- High-Throughput Targeted Repeat Element Bisulfite Sequencing (HT-TREBS) -- A Pipeline for ctDNA Detection Following Primary Tumor Profiling Using A Cancer-related Gene Sequencing Panel -- Single-cell Analysis of Circulating Tumor Cells
    Abstract: This book provides a practical guide to current methods for profiling and interpreting genomic alterations in tumors. Chapters detail methods to interrogate DNA variation, RNA expression, and epigenetic changes using both next-generation sequencing and microarray techniques, common bioinformatics and annotation tools to glean relevant driver genomic events, and different performance characteristics as well as quality metrics necessary for the robust validation of tumor profiling as a diagnostic test for medical laboratories. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Tumor Profiling: Methods and Protocols aims to be a useful resource for learning about technical details, applications, and strengths and limitations of the latest technologies as applied to this increasingly important field
    Pages: XI, 268 p. 72 illus., 57 illus. in color. : online resource.
    ISBN: 9781493990047
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  • 19
    Keywords: Medical genetics ; Medicine ; Biochemistry ; Neurosciences ; Gene Function ; Molecular Medicine ; Protein Science ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Chapter 1. Molecular and Functional Properties of Progranulin -- Chapter 2. Progranulin as a biomarker for neurodegenerative diseases -- Chapter 3. PGRN and FTLD -- Chapter 4. PGRN and neurodegenerative diseases other than FTLD -- Chapter 5. Progranulin Regulations of Lysosomal Homeostasis and its Involvement in Neurodegenerative Diseases -- Chapter 6. Molecular and Functional Properties of Progranulin -- Chapter 7. PGRN and neuroinflammation -- Chapter 8. Neural Stem/Progenitor Cells and Progranulin -- Chapter 9. Generation and phenotyping of progranulin-deficient mice -- Chapter 10. Pleiotropic protective effects of progranulin in the treatment of ischemic stroke -- Chapter 11. New therapeutic approaches against ocular diseases
    Abstract: This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students
    Pages: VII, 183 p. 37 illus., 13 illus. in color. : online resource.
    ISBN: 9789811361869
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  • 20
    Keywords: Medicine ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Approach and Nature of Palliative Care -- Quality of Life -- Global Aspects of Palliative Care -- Challenges and Future Directions of Palliative Care -- Organization of Palliative Care in Different Parts of the World -- Policies on Palliative Care in Different Parts of the World -- Palliative Care, Towards a New Definition -- Physical, Psychological/Psychiatric, Social and Spiritual Problems and Symptoms -- Pain and Pain Management -- Palliative Management of Breathlessness -- Fatigue -- Edema and Lymphedema -- Gastrointestinal Symptoms: Constipation, Diarrhea, and Intestinal Obstruction -- Gastrointestinal Symptoms: Nausea and Vomiting -- Cachexia/Anorexia and Feeding Difficulties -- Mouth -- Skin Symptoms -- Swallowing Difficulties -- Sleep Difficulties -- Psychological Symptoms -- Delirium and Palliative Care -- Neurological Symptoms -- Genitourinary Symptoms -- End-of-life Symptoms -- Gastroparesis and Cancer-Related Gastroparesis -- Advance Care Planning in Palliative Care -- Prognostication in Palliative Care -- Spirituality in Palliative Care -- Access to Palliative Care -- Integrated Palliative Care: Clinical, Organizational, and Health System Perspectives -- Family Focused Care Span -- Grief and Bereavement -- Rehabilitation in Palliative Care -- Dietetics and Nutrition in Palliative Care -- Mouth Care -- Creative Art Making in Palliative Care -- Music Engagement and Therapeutic Music -- Sexuality and Intimacy -- Interprofessional Practice in Palliative Care -- Generalists and Specialist Palliative Care -- Nursing and Palliative Care -- Self-Care and Palliative Care -- End of Life Care -- Self-management in Palliative Care -- Education and Palliative Care, Overview -- Palliative Care in Rural Settings -- Home Care, Primary Care -- Palliative Care in Residential Settings -- Hospital Care -- Palliative Care in the Intensive Care Unit (ICU) -- Volunteers in Palliative Care -- Palliative Care and Cancer -- Palliative Care and Neurodegenerative Diseases -- Palliative Care and Stroke -- Palliative Care in Heart Failure -- Palliative care of Respiratory Disease in Primary Care -- Palliative Care and Liver Diseases -- Palliative Care in Kidney Disease -- Palliative Care and Endocrine Diseases -- Palliative Care in Chronic Illness and Multimorbidity -- Palliative care in dementia -- Dealing with a Wound in Palliative Care -- Pressure Area Management in Palliative care -- End of Life Health Care Experiences of Indigenous People and Ethnic Minorities; the example of Canada -- Palliative Care, Frailty and Older People -- Palliative Care of Pediatric Populations -- Palliative Care and Intellectual Disability -- Palliative Care of Indigenous Peoples and Peoples of Different Ethnicity -- Hypercalcemia of Malignancy -- Thromboembolism and bleeding -- Spinal Cord Compression -- Superior Vena Cava Obstruction -- Acute Cancer Pain Syndromes in Palliative Care Emergencies -- Acute Dyspnoea -- Neutropenic Sepsis -- Seizures -- Tumor Lysis Syndrome -- Suicide and Attempted Suicide -- Transfer to a Preferred Place of Death -- Challenging Family Dynamics -- Delirium as a Palliative Care Emergency -- Distinguishing and Managing Severe Psychological and Psychiatric Distress -- End-Of-Life Decisions -- Sedation and Terminal Sedation -- Nutrition and Hydration in Palliative Care -- Ethics of home-coming -- Request for Assisted Suicide -- Public Health and Epidemiological Research in Palliative Care -- Development and Evaluation of Complex Interventions in Palliative Care -- Mixed Method Research in Palliative Care -- Ethics in Palliative Care Research -- Evidence based Practice in Palliative Care -- New Public Health Approaches to End of Life Care -- A public health approach to integrate palliative care into a country’s health care system: guidance as provided by the WHO -- Measuring Cost-Effectiveness in Palliative Care -- Financial Aspects of Inpatient Palliative Care -- Financial Aspects of Outpatient Palliative Care -- Serious Illness and Out-of-Pocket Spending
    Abstract: Textbook of Palliative Care is a comprehensive, clinically relevant and state-of-the art book, aimed at advancing palliative care as a science, a clinical practice and as an art. Palliative care has been part of healthcare for over fifty years but we still find ourselves having to explain its nature and practice to colleagues and to the public in general. Healthcare education and training has been slow to recognize the vital importance of ensuring that all practitioners have a good understanding of what is involved in the care of people with serious or advanced illnesses and their families. However, the science of palliative care is advancing and our understanding concerning many aspects of palliative care is developing rapidly. The book is divided into separate sections for ease of use. Over 100 chapters written by experts in their given fields provide up-to-date information on a wide range of topics of relevance to those providing care towards the end of life no matter what the disease may be. We present a global perspective on contemporary and classic issues in palliative care with authors from a wide range of disciplines involved in this essential aspect of care. The Textbook includes sections addressing aspects such as symptom management and care provision, organization of care in different settings, care in specific disease groups, palliative care emergencies, ethics, public health approaches and research in palliative care. This Textbook will be of value to practitioners in all disciplines and professions where the care of people approaching death is important, specialists as well as non-specialists, in any setting where people with serious advanced illnesses are residing. It is also an important resource for researchers, policy-and decision-makers at national or regional levels. Neither the science nor the art of palliative care will stand still so we aim to keep this Textbook updated as the authors find new evidence and approaches to care
    Pages: 194 illus., 161 illus. in color. eReference. : online resource.
    ISBN: 9783319777405
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  • 21
    Keywords: Genetics ; Human Genetics ; Medical virology ; Medicine ; Genetics and Genomics ; Human Genetics ; Virology ; Learning & Instruction ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Monogenic Disorders -- Cytogenetics -- Medical Genetics -- Viral Gene Therapy
    Abstract: This textbook helps you to prepare for your next exams and practical courses by combining theory with virtual lab simulations. The “Labster Virtual Lab Experiments” series gives you a unique opportunity to apply your newly acquired knowledge in a learning game that simulates exciting laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn’t have access to. In this book, you’ll learn the fundamental concepts of the genetics of human diseases focusing on: Monogenic Disorders - Cytogenetics - Medical Genetics - Viral Gene Therapy In each chapter, you’ll be introduced to one virtual lab simulation and a true-to-life challenge. Following a theory section, you’ll be able to play the relevant simulation that includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye. If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you’re using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer. If you like this book, try out other topics in this series, including “Basic Biology”, “Basic Genetics”, and “Basic Biochemistry”. About Labster Labster is a company dedicated to developing virtual lab simulations that are designed to stimulate students’ natural curiosity and highlight the connection between science and the real world. These simulations have been shown to improve the achievement of learning outcomes among students, by making the learning experience more immersive and engaging. The content of this book was created by the Labster team members Dr. Aaron Gardner, Dr. Sarah Stauffer, Dr. Lindsay Petley-Ragan, Philip Wismer, Dewi Ayu Kencana Ungu and Silvia Tjong. You can learn more about Labster and explore the simulations at www.labster.com
    Pages: IX, 76 p. 43 illus. in color. : online resource.
    ISBN: 9783662587447
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  • 22
    Keywords: Microbiology ; Emerging infectious diseases ; Medicine ; Medical Microbiology ; Infectious Diseases ; Health Promotion and Disease Prevention ; Springer eBooks
    Description / Table of Contents: Buruli Ulcer: History and Disease Burden -- Buruli Ulcer in Africa -- Buruli Ulcer in Australia -- Mycobacterium Ulcerans Infection in French Guiana; Current State of Knowledge -- Buruli Ulcer in Japan -- Population Genomics and Molecular Epidemiology of Mycobacterium Ulcerans -- Mycolactone: More Than Just a Cytotoxin -- The Immunology of Buruli Ulcer -- Buruli Ulcer in Animals and Experimental Infection Models -- Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives -- Antimicrobial Treatment of Mycobacterium Ulcerans Infection -- Thermotherapy of Buruli Ulcer -- Secondary Infection of Buruli Ulcer Lesions -- Management of BU-HIV Co-infection -- Social Science Contributions to BU Focused Health Service Research in West-Africa -- Transdisciplinary Research and Action to Stop Buruli Ulcer– A Case Study from Philanthropy
    Abstract: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans
    Pages: X, 287 p. 34 illus., 30 illus. in color. : online resource.
    ISBN: 9783030111144
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  • 23
    Keywords: Medicine ; Cardiology ; Oncology ; Cytology ; Molecular Medicine ; Cardiology ; Cancer Research ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Advancements in Managing Intracerebral Hemorrhage: Transition from Nihilism to Optimism -- Mandibular Advancement Devices in Patients with Symptoms of Obstructive Sleep Apnea: A Review -- Online Health Technologies and Mobile Devices: Attitudes, Needs and Future -- Radiological Response and Neutrophil-to-Lymphocyte Ratio as Predictive Factors for Progression-Free and Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib -- Plasminogen Activator Inhibitor Type 1 in Blood at Onset of Chemotherapy Unfavorably Affects Survival in Primary Ovarian Cancer -- Sialidase Attenuates Epidermal Growth Factor Response and Abolishes Antiproliferative Effects of Erlotinib in A549Alveolar Epithelial Cells -- Systemic Sclerosis and Serum Content of Transforming Growth Factor -- Protein-Bound Solute Clearance during Hemodialysis -- Mold Sensitization in Asthmatic and Non-Asthmatic Subjects Diagnosed with Extract-Based versus Component-Based Allergens -- Fructose Consumption and Lipid Metabolism in Obese Children and Adolescents -- Vaccination against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement -- Variability of Dry-Eye Disease Following Removal of Lacrimal Glands in Rats
    Abstract: This book shares the latest research and practice-oriented findings in medical sciences with a wide audience. It addresses a range of contemporary issues, often unresolved or contentious, across various medical fields, including advances in the management of hemorrhagic brain stroke. It also discusses metastatic renal cell carcinoma – a global scourge with an extremely poor long-term survival prognosis, the course and sequelae of renal cell carcinoma, as well as advances in targeted molecular therapy with sunitinib, a receptor tyrosine kinase inhibitor. Further, it examines the molecular targeting of proliferative signaling of the epidermal growth factor receptor in the first-line treatment of patients with metastatic non-small-cell lung cancer. Other articles cover clearance of toxins in hemodialyzed patients; the search for diagnostic and therapeutic markers in the connective tissue disease scleroderma; obesity linked to inappropriate dietary habit; clinical problems related to the diagnosis of sensitization to fungi and its role in asthma; and reasons for the perilous trend of avoiding basic vaccinations in children. Lastly, the book explores the rapid developments in e-health technologies that increase access to health services, particularly for the elderly. The book is intended for clinical specialists, researchers, and all allied health professionals from various fields
    Pages: VI, 115 p. 17 illus., 10 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030190590
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  • 24
    Keywords: Cardiovascular System ; Biomedical Engineering ; Cardiology ; Medicine ; Cardiovascular Biology ; Biomedical Engineering/Biotechnology ; Biomedical Engineering and Bioengineering ; Cardiology ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Chapter 1: Biomechanics -- Chapter 2: Morphometry of Coronary Vasculature -- Chapter 3: Mechanical Properties and Microstructure of the Coronary Vasculature -- Chapter 4: Constitutive Models of Coronary Vasculature -- Chapter 5: Network Analysis of Coronary Circulation: I. Steady State Flow -- Chapter 6: Network Analysis of Coronary Circulation: II. Pulsatile Flow -- Chapter 7: Scaling Laws of Coronary Vasculature -- Chapter 8: Local Coronary Flow and Stress Distribution
    Abstract: This comprehensive text examines both global and local coronary blood flow based on morphometry and mechanical properties of the coronary vasculature. Using a biomechanical approach, this book addresses coronary circulation in a quantitative manner based on models rooted in experimental data that account for the various physical determinants of coronary blood flow including myocardial-vessel interactions and various mechanisms of autoregulation. This is the first text dedicated to a distributive analysis (as opposed to lumped) and provides digital files for detailed anatomical data (e.g., diameters, lengths, node-to-node connections) of the coronary vessels. This book also provides appendices with specific mathematical formulations for the biomechanical analyses and models in the text. Written by Dr. Ghassan S. Kassab, a leader in the field of coronary biomechanics, Coronary Circulation: Anatomy, Mechanical Properties, and Biomechanics is a synthesis of seminal topics in the field and is intended for clinicians, bioengineers, and researchers as a compendium on the topic. The detailed anatomical and mechanical data provided are intended to be used as a platform to address new questions in this exciting and clinically very important research area
    Pages: XVII, 564 p. 171 illus., 49 illus. in color. : online resource.
    ISBN: 9783030148195
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  • 25
    Keywords: Medicine ; Monoclonal antibodies ; Molecular Medicine ; Antibodies ; Springer eBooks
    Description / Table of Contents: Purification of Large Cytosolic Proteases for In Vitro Assays: 20S and 26S Proteasomes -- Analysis of Proteasome Generated Antigenic Peptides by Mass Spectrometry -- Trimming of MHC Class I Ligands by ERAP Aminopeptidases -- Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases -- Testing the Impact of Protease Inhibitors in Antigen Presentation Assays -- In Vitro Studies of MHC Class I Peptide Loading and Exchange -- Measuring Synthesis and Degradation of MHC Class I Molecules -- Biochemical Analysis of Naturally Processed Antigenic Peptides Presented by MHC Class I Molecules -- A SIINFEKL Based System to Measure MHC Class I Antigen Presentation Efficiency and Kinetics -- Purification and Identification of Naturally Presented MHC Class I and II Ligands -- Identification of MHC Ligands and Establishing MHC Class I Peptide Motifs -- Quantitating MHC Class I Ligand Production and Presentation using TCR-Like Antibodies -- Identifying Antigens Recognized by Cytolytic T Lymphocytes on Tumors -- A Flow Cytometry-Based Approach to Unravel Viral Interference with the MHC Class I Antigen Processing and Presentation Pathway -- Evaluating CD8+ T Cell Responses In Vitro -- Recombinant Poxviruses: Versatile Tools for Immunological Assays -- Monitoring the Intracellular Routing of Internalized Antigens by Immunofluorescence Microscopy -- Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases -- Monitoring MHC-II Endocytosis and Recycling using Cell-Surface Protein Biotinylation-Based Assays -- Monitoring Protein Endocytosis and Recycling using FACS-Based Assays -- In Vitro Digestion with Proteases Producing MHC Class II Ligands -- Assembly, Intracellular Transport and Release of MHC Class II Peptide Receptors -- Pulse-Chase Analysis for Studies of MHC Class II Biosynthesis, Maturation, and Peptide Loading -- Studying MHC Class II Peptide Loading and Editing In Vitro -- Monitoring Antigen Processing for MHC Presentation via Macroautophagy -- Identification of Human Antigen-Specific CD4+ T-Cells with Peptide-MHC Multimer Technologies -- Production of Antigen Specific Human CD4+ T Cell Lines and Clones -- Monitoring Dendritic Cell Activation and Maturation -- Studying MHC Class II Presentation of Immobilized Antigen by B Lymphocytes -- Analyzing Antigen Recognition by Natural Killer T Cells
    Abstract: The second edition volume expands on the previous edition with new and updated chapters on the latest methods used for studying presentation of antigenic peptides produced in the standard processing pathways for MHC class I and II molecules. The new chapters cover topics such as biochemical and cellular approaches to study the impact of the endoplasmic reticulum aminopeptidases; techniques to monitor MHC class I synthesis and degradation; approaches to measure processing efficacy; description of different assays measuring MHC recycling; and protocols to produce MHC class II tetramers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Antigen Processing: Methods and Protocols, Second Edition is a valuable tool for both novice and expert researchers interested in studying antigen processing and venturing out further into this evolving field
    Pages: XV, 458 p. 79 illus., 45 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9781493994502
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  • 26
    Unknown
    Berlin : Springer
    Keywords: Oncology ; Medicine ; Oncology   ; Cancer Research ; Molecular Medicine ; Oncology ; Springer Nature Living Reference
    Abstract: The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in℗ 7 Volumes with an A-Z format of℗ approx. 7000℗ entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative℗ Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public
    Pages: LXXXVI, 3984 p. 1071 illus., 710 illus. in color. : online resource.
    ISBN: 9783642278419
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  • 27
    Unknown
    Dordrecht : Springer
    Keywords: Medicine ; Cytology ; Diabetes ; Bioorganic chemistry ; Human Physiology ; Biomedicine general ; Cell Biology ; Diabetes ; Science, Humanities and Social Sciences, multidisciplinary ; Bioorganic chemistry ; Human Physiology ; Springer Nature Living Reference
    Description / Table of Contents: Microscopic Anatomy of the Human Islet of Langerhans -- The Comparative Anatomy of Islets -- Approaches for Imaging Islets: Recent Advances and Future Prospects -- Islet Cell Development -- High Fat Programming of β-Cell Failure -- Electrophysiology of Islet Cells -- ATP-Sensitive Potassium Channels in Health and Disease -- Role of Mitochondria in β-cell Function and Dysfunction -- Basement Membrane in Pancreatic Islet Function -- Calcium Signaling in the Islets -- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets -- Exocytosis in Islet β-Cells -- Proteomics and Islet Research -- Wnt Signaling in Pancreatic Islets -- Mechanisms of Pancreatic β-Cell Apoptosis in Diabetes and Its Therapies -- β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice] -- Islet Structure and Function in the GK Rat -- The β-Cell in Human Type 2 Diabetes -- Clinical Approaches to Preserve β-Cell Function in Diabetes -- Immunology of β-Cell Destruction -- Prevention of β-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects -- Islet Isolation for Clinical Transplantation -- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead -- Modulation of Early Inflammatory Reactions to Promote -- Successes and Disappointments with Clinical Islet Transplantation -- Exercise-induced pancreatic islets adaptations in health and disease -- Role Reg family proteins on islet cell growth and survival -- Circadian control of islet function -- Zinc Transporters in the pancreas -- Making Islets from Human Embryonic Stem Cells -- Chloride channels and Transporters in ß-cell physiology -- Pancreatic beta cells in metabolic syndrome -- Insulin and IGF-1 receptor signalling in insulin secreting cells -- Beta cell store-operated ion channels -- Isolation of Rodent Islets of Langerhans -- Anionic Transporters and Channels in Pancreatic Islet Cells -- Glucose-Induced Apoptosis in Pancreatics Islets -- In Vivo Biomarkers for Detection of Beta Cell Death -- Inflammatory Pathways Linked to Beta Cell Demise in Diabetes -- Islet Encapsulation -- Islet Isolation for Autotransplantation -- Islet Xenotransplantation: recent advances and future prospects -- Molecular basis of cAMP signaling in pancreatic beta cells -- NADPH Oxidase in Beta Cell Dysfunction -- Pancreatic Neuroendocrine Tumors -- Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic Alpha-Cells -- Reproductive Hormones and Islet Adaptation to Metabolic Stress -- Stem Cells in Pancreatic Islets -- Transcriptional co-Activators in Beta-Cell Function and Disease Pathology
    Abstract: This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book
    Pages: 800 p. 240 illus., 200 illus. in color. : online resource.
    ISBN: 9789400768840
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  • 28
    Keywords: Oncology ; Human Genetics ; Medicine ; Cytology ; Cancer Research ; Human Genetics ; Molecular Medicine ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Preface -- Hypoxia mediates tumor malignancy -- Clinical methods for quanitifying hypoxia in human tumors -- Hypoxia-induced phenotypes that mediate tumor heterogeneity -- Hypoxia and the tumors secretome -- Hypoxic signaling in angiogenesis and lymphangiogenesis -- Hypoxia induced metabolic reprogramming in cancer metastasis -- The metastatic niche and hypoxia -- Hypoxia and immune suppression -- Hypoxia-induced resistance to cancer therapy -- Therapeutic stratagies to target the hypoxic microenvironment -- Index
    Abstract: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease
    Pages: VIII, 160 p. 17 illus., 16 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030127343
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  • 29
    Keywords: Oncology ; Immunology ; Medicine ; Cancer Research ; Immunology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index
    Abstract: This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients
    Pages: XIX, 256 p. 21 illus. in color. : online resource.
    ISBN: 9783030166243
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  • 30
    Keywords: Biomedical Engineering ; Geriatrics ; Medicine ; Human Genetics ; Metabolism ; Biomedical Engineering/Biotechnology ; Geriatrics/Gerontology ; Molecular Medicine ; Human Genetics ; Metabolomics ; Regenerative Medicine/Tissue Engineering ; Springer eBooks
    Description / Table of Contents: Part I Alterations in Nervous System, Genes, Hormones and Immunity during Aging. - Neurological problems of the Elderly -- Molecular marker and therapeutic regimen for neurodegenerative diseases -- Neurodegeneration during Aging: Role of Oxidative Stress through Epigenetic Modifications -- Polyglucosan Bodies in Aged Brain and Neurodegeneration: Cause or Consequence? -- Signaling of Nociceptors and Pain Perception: Impact of age -- Association between Ageing and REM sleep loss: Noradrenaline acting as a mediator -- Age related changes in the human retina: a role for oxidative stress. - Ageing: Influence on Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) -- Mitophagy, Diseases and Aging -- Genetics, Ageing and Human Health -- Genetic Syndromes and Aging -- Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging -- Sex Steroids, Cognate Receptors and Aging -- Immunosenesence, Inflammaging and their implications for Cancer and Anemia -- Bone Marrow Stem Cells, Aging and Age-related Diseases -- Part II Interventions for Healthy Aging -- Infantile radiation and Aging Stresses: Effects of Calorie and Dietary Restrictions -- Mechanisms and Late Life Intervention of Aging -- Healthy Ageing and Cancer in Humans -- Nutrition for elderly -- Care of older persons in India: scope of policy and technology tools
    Abstract: This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers
    Pages: XI, 436 p. 86 illus., 55 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811335853
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  • 31
    Keywords: Medicine ; Enzymes ; Human Physiology ; Metabolic Diseases ; Molecular Medicine ; Enzymology ; Human Physiology ; Metabolic Diseases ; Springer eBooks
    Description / Table of Contents: 1. Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects -- 2. Environmental aldehyde sources and the health implications of exposure -- 3. ALDH2 and cardiovascular disease -- 4. Aldehyde dehydrogenases: From alcohol metabolism to human health and precision medicine -- 5. Aldehyde dehydrogenase 2 and heart Failure -- 6. Mitochondrial aldehyde dehydrogenase in myocardial ischemic and ischemia-reperfusion injury -- 7. East Asian variant aldehyde dehydrogenase 2 genotype (ALDH2*2*) contributes to coronary artery spasm and acute myocardial infarction -- 8. Aldehyde dehydrogenases genetic polymorphism and obesity: from genomics to behavior and health -- 9. Aldehyde dehydrogenase (ALDH) 2 in diabetic heart diseases -- 10. The role of ALDH2 in sepsis and the to-be-discovered mechanisms -- 11. ALDH2 and stroke -- 12. ALDH2 and hypertension -- 13. ALDH2 and cancer therapy -- 14. ALDH2 polymorphism and ethanol consumption: A genetic-environmental interaction in carcinogenesis -- 15. ALDH2 and aging
    Abstract: This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource
    Pages: XX, 253 p. 27 illus., 20 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811362606
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  • 32
    Keywords: Medicine ; Biology / Data processing ; Science / Study and teaching ; Bioinformatics ; Ability ; Biological models ; Molecular Medicine ; Computer Appl. in Life Sciences ; Science Education ; Computational Biology/Bioinformatics ; Skills ; Systems Biology ; Springer eBooks
    Description / Table of Contents: Introduction: What is Matlab and what can it be used for -- Overview of Interface -- Toolboxes -- The basics using the command line: Element by element versus matrix multiplication -- Multiplying and dividing arrays of data -- Example 1: Next generation matrix models -- Creating and using script files: Debugging scripts -- Using the live editor -- Accessing help -- Exploring Matlab’s in-built functions -- Creating graphs and plots: Example 1: Introduction to the image processing toolbox -- Example 2: Plotting ellipses, hyperbola and parabola (conic sections) -- Anonymous functions -- Creating separate function files: Example 1: solving a differential equation using ode45 using biological examples -- Importing and exporting data: Example 1: reading spreadsheets using the command line and an application of linear algebra to statistical analysis of qpcr data -- Matlab as a programming language: Introduction to using loops in your scripts -- For loops -- While loops -- Combining loops and conditional statements
    Abstract: This textbook takes you from the very first time you open MATLAB® through to a position where you can comfortably integrate this computer language into your research or studies. The book will familiarise you with the MATLAB interface, show you how to use the program´s built-in functions and carefully guide you towards creating your own functions and scripts so that you can use MATLAB as a sophisticated tool to support your own research. A central aim of this book is to provide you with the core knowledge and skills required to become a confident MATLAB user so that you can find and make use of the many specialist functions and toolboxes that have been developed to support a wide range of biological applications. Examples presented within the book are selected to be relevant to biological scientists and they illustrate some of the many ways the program can be incorporated into, and used to enhance, your own research and studies. The textbook is a must-have for students and researchers in the biological sciences. It will also appeal to readers of all backgrounds who are looking for an introduction to MATLAB which is suitable for those with little or no experience of programming
    Pages: XIII, 175 p. 30 illus., 27 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030213374
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  • 33
    Keywords: Stem Cells ; Medicine ; Stem Cells ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Flow Cytometry Analysis to Identify Human CD8+ T-Cells -- Flow Cytometry Analysis to Identify Human CD4+ T-Cell Subsets -- Gene Modification and Immunological Analyses for the Development of Immunotherapy Utilizing T-Cells Redirected with Antigen-Specific Receptors -- In Vitro Conversion of Activated T-Cells into Stem Cell Memory-Like T-Cells -- Human iPSC Generation from Antigen-Specific T-Cells -- In Vitro Differentiation of T-Cells: From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells -- Redifferentiation of Adaptive Naïve-Like CTL from T-Cell-Derived iPSC -- In Vitro Differentiation of T-Cell: From Human iPS Cells in Feeder Free Condition -- Differentiating CD8ab T-Cells from TCR Transduced iPSCs for Cancer Immunotherapy -- In Vitro Differentiation of T-Cell: From CAR-Modified T-iPSC -- In Vitro Differentiation of T-Cells: From Non-Human Primate Induced Pluripotent Stem Cells -- An Improved Method to Produce Clinical Scale Natural Killer Cells from Human Pluripotent Stem Cells -- In Vitro Detection of Cellular Adjuvant Properties of Human Invariant Natural Killer T-Cells -- In Vitro Differentiation of T-Cells from Murine Pluripotent Stem Cells -- Clonogenic Culture of Mouse Thymic Epithelial Cells -- Single-Cell Transcriptome Analysis of T-Cells -- Structural Modeling of Lymphocyte Receptors and Their Antigens -- Assessing T Lymphocyte Aging Using Telomere Length and Telomerase Activity Measurements in Low Cell Numbers -- Generation of Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells -- Using the Inducible Caspase9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking
    Abstract: This book explores the vital importance of T-cell differentiation in areas as wide-ranging as pathological analysis, drug development, and cell therapy of human T-cells. Focusing on human embryonic stem cells and human induced pluripotent stem cells, the chapters explore a variety of in vitro T-cell differentiation protocols as well as useful techniques to develop and evaluate cellular medicines. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, In Vitro Differentiation of T-Cells: Methods and Protocols serves as an ideal guide for researchers seeking to differentiate T-cells from pluripotent stem cells in order to achieve any number of significant goals
    Pages: XI, 267 p. 60 illus., 45 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9781493997282
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  • 34
    Keywords: Oncology ; Oncology   ; Medicine ; Toxicology ; Cancer Research ; Oncology ; Molecular Medicine ; Pharmacology/Toxicology ; Springer Nature eReference
    Abstract: This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented
    Pages: 63 illus., 58 illus. in color. eReference. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783319336732
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  • 35
    Keywords: Medicine ; Epidemiology ; Public Health ; Biostatistics ; Statistics  ; Artificial intelligence ; Biomedicine, general ; Epidemiology ; Public Health ; Biostatistics ; Statistics for Life Sciences, Medicine, Health Sciences ; Artificial intelligence ; Springer eBooks
    Description / Table of Contents: Foreword -- Preface -- Acknowledgements -- Essence of Clinical Medicine -- Essence of Clinical Research -- Clinical Research and Clinical Medicine at present -- Clinical Research Transformative of Clinical Medicine -- Core Concepts of Epidemiology and Epidemiological Research -- The Epidemiological Interface of Gnostic Clinical Research -- The Logistic Regression Model -- Statistics from the Model’s Fitting to Gnostic Data -- The Types of Diagnostic Challenge and Needs for Knowledge -- Harvesting Experts’ Diagnostic Probability Estimates -- Objects Design for a Diagnostic Probability Study -- Methods Design for a Diagnostic Probability Study -- The Bayes’ Theorem Framework for Diagnostic Research -- Research Focused on Diagnostic Tests -- Introduction to Etiognostic Research -- Objects Design for an Etiognostic Study -- Methods Design for an Etiognostic Study -- Introduction to Prognostic Research -- Example: Research on ‘Hormone Replacement Therapy’ -- Prognostic Probability Functions from Clinical-trial Data -- Non-experimental Intervention-prognostic Studies -- Intervention-prognostic Derivative Research -- Theory of Medicine Defining the Essential Missions for Clinical Research -- Theory of Clinical Research for Its Essential - Gnosis-serving - Missions -- Toward Worldwide Scientific Clinical Medicine -- Glossary -- Appendix 1: What about ‘Machine Learning’?- Appendix 2: On Excellence of Epidemiologic Academia -- Index
    Abstract: This book delineates the fundamental transformations that, according to its precepts, are now needed in the objects and methods of ́€˜patient-oriented́€™ clinical research, in order to make it genuinely patient-relevant. These transformations are presented as providing for transition from todaý€™s €˜évidence-based́€™ practices (advocated by ́€˜clinical epidemiologistś€™) to knowledge-based succedanea of these. While those existing practices vary according to doctorś€™ personal opinions about the burden of the available evidence, their knowledge-based succedanea will be essentially invariant across individual doctors, as theý€™ll be guided by €˜éxpert systemś€™ (imbedded in cyberspace). At issue in this is transformation in what the authors present as the very essence of clinical medicine, namely clinical doctorś€™ esoteric ad-hoc knowing: ́€œgnosis.́€ This is clinical doctorś€™ knowing ́€” probabilistic ́€” about relevant-but-hidden truths about their patientś€™ health, and constitutes the basis for their teaching (́€œdoctorinǵ€) the patients about these esoteric insights. The probabilities are ́€˜personalized́€™ in the meaning of their specificity to the caseś€™ gnostic profiles. Genuinely patient-relevant clinical knowledge this book presents as the requisite basis for three species of clinical doctorś€™ gnosis: diagnosis ́€” knowing about whether a particular type of illness is present (though hidden) in the patient; etiognosis ́€” knowing about whether the patient́€™s illness was caused by a particular antecedent of it; and prognosis ́€” knowing about the patient́€™s future health, including as to its dependence on the choice of treatment. Pivotal in gnostic clinical research this book presents to be the studieś€™ objects design in terms of a statistical model for the rate of occurrence of the entity of health in question, in a defined domain of case presentations. The essentials of the studieś€™ methods designs are deduced from their objects designs. Study of this book ́€” on the theory of ́€œmeta-epidemiological clinical research́€ ́€” is essential preparation for teaching ́€˜patient-oriented́€™ clinical research and for actual design & conduct of the studies and of their critical reviews. And by the same token, study of this book is essential preparation for the needed replacement of ́€˜case-based learninǵ€™ of clinical medicine, for suitably-learned teaching of the practice of clinical medicine ́€” focused on the status quo of the scientific knowledge-base for (gnoses in) the discipline (́€˜specialtý€™) at issue
    Pages: XXIV, 302 p. 2 illus. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030061760
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  • 36
    Keywords: Developmental Biology ; Evolutionary Biology ; Animal models in research ; Medicine ; Cell Physiology ; Biodiversity ; Developmental Biology ; Evolutionary Biology ; Animal Models ; Biomedicine, general ; Cell Physiology ; Biodiversity ; Springer eBooks
    Description / Table of Contents: Part I. Theoretical Background -- Reflections on Model Organisms in Evolutionary Developmental Biology -- Hourglass or Twisted Ribbon? -- Ambulacrarians and the Ancestry of Deuterostome Nervous Systems -- Part II. New and Emerging Model Systems in Evo-Devo Research -- Oikopleura Dioica: An Emergent Chordate Model to Study the Impact of Gene Loss on the Evolution of the Mechanisms of Development -- Neuropeptides, Peptide Hormones, and Their Receptors of a Tunicate, Ciona Intestinalis -- Emergence of Embryo Shape during Cleavage Divisions -- Sex Determination, Sexual Development, and Sex Change in Slipper Snails -- The Cricket Gryllus Bimaculatus: Techniques for Quantitative and Functional Genetic Analyses of Cricket Biology -- The Rove Beetle Creophilus Maxillosus as a Model System to Study Asymmetric Division, Oocyte Specification, and the Germ-Somatic Cell Signaling -- Cell Biology of the Tardigrades – Current Knowledge and Perspectives -- Development of Xenoturbellida -- Cellular and Molecular Mechanisms of Hydra Regeneration -- Paramecium Biology -- Part III. Evo-Devo in Comparative Context -- Insights into Germline Development and Differentiation in Molluscs and Reptiles: The Use of Molecular Markers in the Study of Non-Model Animals -- Molecular Markers in the Study of Non-model Vertebrates: Their Significant Contributions to the Current Knowledge of Tetrapod Glial Cells and Fish Olfactory Neurons -- Embryogenesis of Marsupial Frogs (Hemiphractidae), and the Changes that Accompany Terrestrial Development in Frogs -- Evolution and Regulation of Limb Regeneration in Arthropods -- Viviparity in Two Closely Related Epizoic Dermapterans Relies on Disparate Modifications of Reproductive Systems and Embryogenesis -- Morphology of Ovaries and Oogenesis in Chelicerates -- Reproduction, Gonad Structure and Oogenesis in Tardigrades -- Architecture and Life History of Female Germ-Line Cysts in Clitellate Annelids
    Abstract: Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book’s content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike
    Pages: XI, 551 p. 137 illus., 110 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030234591
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  • 37
    Unknown
    New York, NY : Springer
    Keywords: Medicine ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Traditional Prenatal Diagnosis: Past to Present -- Overview of Preimplantation Genetic Diagnosis (PGD): Historical Perspective and Future Direction -- Non-Invasive Approaches to Prenatal Diagnosis: Historical Perspective and Future Directions -- Molecular Testing for Preimplantation Genetic Diagnosis of Single Gene Disorders -- Detection of Aneuploidy and Unbalanced Rearrangements using Comparative Genomic Hybridization Microarrays -- Aneuploidy Screening using Next Generation Sequencing -- DNA Extraction from Various Types of Prenatal Specimens -- Assessment of Maternal Cell Contamination in Prenatal Samples by Quantitative Fluorescent PCR (QF-PCR) -- Rapid Prenatal Aneuploidy Screening by Fluorescence In Situ Hybridization (FISH) -- Prenatal Detection of Chromosome Aneuploidy by Quantitative Fluorescence PCR -- Multiplex Ligation-Dependent Probe Amplification (MLPA) for Prenatal Diagnosis of Common Aneuploidies -- Chromosomal Microarray Analysis using Array Comparative Genomic Hybridization on DNA from Amniotic Fluid and Chorionic Villus Sampling -- Prenatal Diagnosis using Chromosomal SNP Microarrays -- Rapid Detection of Fetal Mendelian Disorders: Thalassemia and Sickle Cell Syndromes -- Prenatal Diagnosis of Cystic Fibrosis -- Prenatal Diagnosis of Tay-Sachs Disease -- Next-Generation Sequencing of Prenatal Structural Chormosomal Rearrangements using Large-Insert Libraries -- Prenatal Diagnosis by Whole Exome Sequencing in Fetuses with Ultrasound Abnormalities -- Quad Screen Test, A Multiplexed Biomarker Assay for Prenatal Screening to Assess Birth Defects: The Columbia University Experience using the Beckman Access2 Immunoassay Analyzer and Benetech PRA -- Isolation of Cell-Free DNA from Maternal Plasma -- Noninvasive Detection of Fetal Aneuploidy using Next-Generation Sequencing -- Noninvasive Antenatal Screening for Fetal RHD in RhD Negative Women to Guide Targeted Anti-D Prophylaxis
    Abstract: This second edition volume expands on the first edition with more detailed methodologies on prenatal testing and diagnosis, and also covers next-generation sequencing techniques. The chapters in this book are divided into three sections: preimplantation genetic testing, traditional prenatal testing, and non-invasive prenatal testing. This book covers topics such as molecular testing for preimplantation genetic diagnosis of single gene disorders; DNA extraction from various types of prenatal specimens; prenatal diagnosis of cystic fibrosis and Tay-Sachs disease; chromosomal SNP microarrays; and isolation of cell-free DNA from maternal plasma. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Prenatal Diagnosis, Second Edition is a valuable resource for any researcher interested in reproducing these techniques in their clinical laboratories
    Pages: XI, 363 p. 35 illus., 28 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9781493988891
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    Keywords: Human Genetics ; Metabolic Diseases ; Pediatrics ; Medicine ; Human Genetics ; Metabolic Diseases ; Pediatrics ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: A Homozygous Splice Site Mutation in SLC25A42, Encoding the Mitochondrial Transporter of Coenzyme A, Causes Metabolic Crises and Epileptic Encephalopathy -- Apparent Acetaminophen Toxicity in a Patient with Transaldolase Deficiency -- Sialuria: Ninth Patient Described Has a Novel Mutation in GNE -- Stability of the ABCD1 Protein with a Missense Mutation: A Novel Approach to Finding Therapeutic Compounds for X-Linked Adrenoleukodystrophy -- Psychosocial Functioning in Parents of MPS III Patients -- The Second Case of Saposin A Deficiency and Altered Autophagy -- An Electronic Questionnaire for Liver Assessment in Congenital Disorders of Glycosylation (LeQCDG): A Patient-Centered Study -- Demographics, Clinical Features, and Mortality of Acute Hepatic Porphyrias in Colombia: An Analysis of 101 Patients -- Cobalamin D Deficiency Identified Through Newborn Screening -- Lathosterolosis: A Relatively Mild Case with Cataracts and Learning Difficulties -- DPAGT1 Deficiency with Encephalopathy (DPAGT1-CDG): Clinical and Genetic Description of 11 New Patients -- Enzyme Replacement Therapy During Pregnancy in Fabry Patients -- Hyperornithinemia, Hyperammonemia, and Homocitrullinuria Syndrome Causing Severe Neonatal Hyperammonemia -- Screening for Niemann-Pick Type C Disease in a Memory Clinic Cohort -- Reversible Cerebral White Matter Abnormalities in Homocystinuria
    Abstract: JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder
    Pages: VI, 119 p. 32 illus., 22 illus. in color. : online resource.
    ISBN: 9783662586174
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    Keywords: Medicine ; Cardiology ; Oncology ; Cytology ; Molecular Medicine ; Cardiology ; Cancer Research ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Left Ventricular Strain and Relaxation are Independently Associated with Renal Cortical Perfusion in Hypertensive Patients -- Coupling of Blood Pressure and Subarachnoid Space Oscillations at Cardiac Frequency Evoked by Handgrip and Cold Tests: a Bispectral Analysis -- Influence of Heart Rate, Age, and Gender on Heart Rate Variability in Adolescents and Young Adults -- Hand-Foot Syndrome and Progression-Free Survival in Patients Treated with Sunitinib for Metastatic Clear Cell Renal Cell Carcinoma -- Elastography in the Diagnosis of Pancreatic Malignancies -- Factors Affecting Health-Related Quality of Life in Liver Transplant Patients -- Phagocytosis and Autophagy in THP-1 cells Exposed to Urban Dust: Possible Role of LC3€“Ássociated Phagocytosis and Canonical Autophagy -- Gendeŕ€“Dependent Responses of Growth and Insuliń€“like Growth Factoŕ€“1 to Growth Hormone Therapy in Prepubertal Growth Hormone Deficient Children -- Vitamin D and Calcium Homeostasis in Infants with Urolithiasis -- Morphometric Analysis of the Lumbar Vertebrae Concerning the Optimal Screw Selection for Transpedicular Stabilization -- Stress and Dehumanizing Behaviors of Medical Staff toward Patients -- Biological and Social Determinants of Maximum Oxygen Uptake in Adult Men
    Abstract: This book focuses on issues in clinical practice and research that are of general interest. The articles primarily focus on understanding the pathogenic mechanisms of diseases, their prevention, and therapy. The topics addressed include cardiovascular regulation with regard to blood pressure and heart rate variability, and to coupling blood pressure changes with subarachnoid fluid oscillations. In addition, the book discusses recent advances in the diagnostics of and targeted molecular therapy for renal and pancreatic malignancies, growth disorders, vitamin D and calcium homeostasis in children in the context of neonatal urolithiasis, and neurosurgical interventions in multifarious age-related diseases of the vertebrae. Neuropsychological aspects of patients’ quality of life and of shaping medical staff’s attitude toward patients are also addressed. The respective articles are intended to build a bridge between basic and clinical research. Further, the book enhances the current body of knowledge on diagnostics and patient treatment and offers valuable new perspectives on practical clinical issues. As such, it offers a unique resource for clinicians, family physicians, medical scholars, and professionals engaged in patient management
    Pages: VI, 114 p. 20 illus. in color. : online resource.
    ISBN: 9783030129231
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    Keywords: Medicine ; Cell Culture ; Nephrology ; Molecular Medicine ; Cell Culture ; Nephrology ; Springer eBooks
    Description / Table of Contents: Generating Genetic Mosaic Mouse Embryos or Organoids for Studies of Kidney Development -- Mouse Ex Vivo Kidney Culture Methods -- Serum-Free Organ Culture of the Embryonic Mouse Ureter -- Experimental Tubulogenesis Induction Model in the Mouse -- Dissociation of Tissues for Single Cell Analysis -- Long Term Culture of Nephron Progenitor Cells Ex Vivo -- 3D Cell Culture Models of Epithelial Tissues -- Generation of Three-Dimensional Nephrons from Mouse and Human Pluripotent Stem Cells -- Generating Multiple Kidney Progenitors and Cell Types from Human Pluripotent Stem Cells -- Protocol to Generate Ureteric Bud Structures from Human iPS Cells -- Investigating Aspects of Renal Physiology and Pharmacology in Organ and Organoid Culture -- Virus as Renal Functional Genetic Tools -- Gene-Editing in 3D Cultured Nephron Progenitor Cell Lines -- Time-Lapse Technologies and 4D Imaging of Kidney Development -- Decellularizing and Recellularizing Adult Mouse Kidneys -- Optical Projection Tomography Imaging to Study Kidney Organogenesis -- Epithelial Function in the Drosophila Malpighian Tubule: An In Vivo Renal Model -- Analysis of the Teashirt Target Genes in Ureteric Bud Development -- Methods of Computational Analysis in Kidney Development
    Abstract: This book details protocols on classical methods and very modern ex vivo mammalian developmental kidney model systems. Chapters focus on generation of mosaic embryonic kidneys, culture of the kidney tissues ex vivo, embryonic kidney progenitor cell, 3Dkidney model cell line based cultures, programming the kidney cell fates in human pluripotent cells, protocols to target the functional players in kidney ontogenesis, 4D and 3D ex vivo imaging, drosphila, and computational approaches to kidney ontogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Organogenesis: Methods and Protocols aims to ensure successful results in the further study of this vital field
    Pages: XI, 248 p. 57 illus., 44 illus. in color. : online resource.
    ISBN: 9781493990214
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    Keywords: Medicine ; Orthopedics ; Molecular Medicine ; Orthopedics ; Springer eBooks
    Description / Table of Contents: Isolation and Generation of Osteoclasts -- Isolation and Generation of Osteoblasts -- Isolation, Purification, Generation, and Culture of Osteocytes -- Isolation, Differentiation, and Characterisation of Human Bone Marrow Stem Cells In Vitro and In Vivo -- 2d and 3d In Vitro Co-Culture For Cancer and Bone Cell Interaction Studies -- Using Cell and Organ Culture Models to Analyse Responses of Bone Cells To Mechanical Stimulation -- The ex vivo Organ Culture of Bone -- Ex-Vivo Model Systems of Cancer-bone Cell Interactions -- Mechanical Properties of Bone ex vivo -- Analysis of Signalling Pathways by Western Blotting and Immunoprecipitation -- Analysis of Transcriptional Regulation in Bone Cells -- Analysis of mRNA, miRNA, and DNA in bone cells by RT-qPCR and In situ Hybridization -- Ovariectomy/Orchiectomy in Rodents -- In Vivo Models of Rheumatoid Arthritis -- Osteoarthritis Mouse Model of Destabilisation of the Medial Meniscus -- Models of Prostate Cancer Bone Metastasis -- Animal Models of Breast Cancer Bone Metastasis -- Murine Models of Bone Sarcomas -- Mouse Models of Melanoma Bone Metastasis -- Animal Models of Multiple Myeloma -- The Calvarial Injection Assay -- In Vivo Models of Mechanical Loading -- Animal Models for the Study of Bone Derived Pain -- Histomorphometry in Rodents -- Immunostaining of Skeletal Tissues -- Techniques for the Study of Apoptosis in Bone -- Live Cell Imaging of Bone Cell and Organ Cultures -- Analysis of Bone Architecture in Rodents using micro Computed Tomography -- Bone Measurements by Peripheral Quantitative Computed Tomography in Rodents -- Quantitative X-ray Imaging of Mouse Bone by Faxitron -- Scanning Electron Microscopy of Bone -- Transmission Electron Microscopy of Bone -- Tracking Cancer Cells Colonisation in Rodent Bone Using Two-photon Microscopy -- Fourier Transform Infrared Imaging of bone -- Raman Microscopy and Bone
    Abstract: This 3rd edition book provides are large number of laboratory protocols that are intended for basic and clinical bone researchers. Chapters are organized into five parts covering methods for isolation, ex vivo models of bone organ and cell co-culture system, biochemical procedures, animal models of bone remodeling, and rodent models on Rheumatoid arthritis and osteoarthritis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge Bone Research Protocols: Methods and Protocols, Third Edition aims to extensive list of protocols for anyone interested in bone research
    Pages: XV, 670 p. 172 illus., 121 illus. in color. : online resource.
    Edition: 3rd ed. 2019.
    ISBN: 9781493989973
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    Keywords: Microbiology ; Medicine ; Emerging infectious diseases ; Medical Microbiology ; Health Promotion and Disease Prevention ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Diagnostics, Therapeutics and Other Potential Strategies of Biodefense -- Advanced Molecular Biology Tools & Diagnostics -- High Containment Infectious Disease Laboratories as an Integral Part of Emergency Preparedness -- Decontamination Capabilities and Facilities -- Virogenomics as a Tool for Molecular Epidemiology and Forensics -- Next Generation Sequencing Tools for Pathogen Detection -- Metagenomics -- Point-of-care Diagnostic Facilities for Outbreak Intervention -- Psychological Impact of Biological Attacks -- Public-health Preparedness -- Viral Therapeutics -- Bacterial Therapeutics -- Emergency Training for Veterinary Professionals -- Global Biodefense Coordination
    Abstract: This second volume of a two-volume set focuses on specific pathogens and their mechanisms of pathogenesis as well as diagnostics, therapeutics and various strategies in the event of biological attacks. This multidisciplinary book appeals to readers from various fields, including biodefense, biosafety & biosecurity, virology, neurology, molecular biology and genetic engineering, as well as infectious disease specialists. Further, the work is of interest to basic science and applied science research scholars and experts working in the area of high-consequence or select agent virology
    Pages: XIII, 383 p. 30 illus., 25 illus. in color. : online resource.
    ISBN: 9783030030711
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  • 43
    Keywords: Bioinformatics ; Medicine ; Statistics ; Bioinformatics ; Biomedicine general ; Statistics for Life Sciences, Medicine, Health Sciences ; Springer eBooks
    Description / Table of Contents: Part 1. BIOINFORMATICS FOR LIFE AND PERSONAL GENOME INTERPRETATION -- Chapter 1. Bioinformatics For Life -- Chapter 2. Next Generation Sequencing and Personal Genome Data Analysis -- Chapter 3. Personal Genome Data Analysis -- Chapter 4. Personal Genome Interpretation and Disease Risk Prediction -- Part 2. ADVANCED MICROARRAY DATA ANALYSIS -- Chapter 5. Advanced Microarray Data Analysis -- Chapter 6. Gene Expression Data Analysis -- Chapter 7. Gene Ontology and Biological Pathway-based Analysis -- Chapter 8. Gene-set Approaches and Prognostic Subgroup Prediction -- Chapter 9. MicroRNA Data Analysis -- Part 3. NETWORK BIOLOGY, SEQUENCE, PATHWAY AND ONTOLOGY INFORMATICS -- Chapter 10. Network Biology, Sequence, Pathway and Ontology Informatics -- Chapter 11. Motif and Regulatory Sequence Analysis -- Chapter 12. Molecular Pathways and Gene Ontology -- Chapter 13. Biological Network Analysis -- Part 4. SNPS, GWAS AND CNVS, INFORMATICS FOR GENOME VARIANTS -- Chapter 14. SNPs, GWAS, CNVs: Informatics for Human Genome Variations -- Chapter 15. SNP Data Analysis -- Chapter 16. GWAS Data Analysis -- Chapter 17. CNV Data Analysis -- Part 5. METAGENOME AND EPIGENOME, BASIC DATA ANALYSIS -- Chapter 18. Metagenome and Epigenome Data Analysis -- Chapter 19. Metagenome Data Analysis -- Chapter 20. Epigenome Databases and Tools -- Chapter 21. Epigenome Data Analysis -- Appendix A. BASIC PRACTICE USING R FOR DATA ANALYSIS -- Appendix B. APPLICATION PROGRAM FOR GENOME DATA ANALYSIS INSTALL GUIDE
    Abstract: This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. This textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics
    Pages: XVI, 367 p. 645 illus., 236 illus. in color. : online resource.
    ISBN: 9789811319426
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  • 44
    Unknown
    Singapore : Springer
    Keywords: Medicine ; Biochemistry ; Molecular Medicine ; Protein Science ; Springer eBooks
    Description / Table of Contents: Part 1: Overview of Periostin -- Chapter 1: Naming, History, Future -- Part 2: Basic properties of Periostin -- Chapter 2: The structure of the periostin gene, its transcriptional control and alternative splicing, and protein expression -- Part 3: Function as the scaffold -- Chapter 3: Periostin functions as a scaffold for assembly of extracellular proteins -- Part 4: Health and Disease in Organs -- Chapter 4: Periostin reexpression in heart disease contributes to cardiac interstitial remodeling by supporting the cardiac myofibroblast phenotype -- Chapter 5: Periostin in bone biology -- Chapter 6: Periostin in bone regeneration -- Chapter 7: Functions of periostin in dental tissues and its role in periodontal tissue regeneration -- Chapter 8: Periostin and human teeth -- Chapter 9: Ability of periostin as a new biomarker of idiopathic pulmonary fibrosis -- Chapter 10: Involvement of periostin in skin function and the pathogenesis of skin diseases -- Chapter 11: Periostin in the kidney -- Chapter 12: Periostin in eye diseases -- Chapter 13: The maltiaspect functions of periostin in tumor progression -- Part 5: Other types of fibrosis and tissue repair -- Chapter 14: Liver, Stroke, Rhinosinusitis -- Part 6: Inflammation -- Chapter 15: Roles of periostin in asthma -- Part 7: Periostin in Development -- Chapter 16: Periostin and integrin signaling in stem cell regulation -- Chapter 17: Role of periostin in cardiac valve development -- Part 8: Biomarker -- Chapter 18: Practical application of periostin as a biomarker for pathological conditions -- Part 9: Clinical applications -- Chapter 19: Clinical trials and new applications
    Abstract: This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases
    Pages: VIII, 213 p. 48 illus., 40 illus. in color. : online resource.
    ISBN: 9789811366574
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    Keywords: Medicine ; Biochemistry ; RNA-ligand interactions ; Pharmaceutical technology ; Molecular Medicine ; Medical Biochemistry ; Protein-Ligand Interactions ; Medicinal Chemistry ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: Final ToC tbd. 1) Description of human carbonic anhydrases (12 catalytically active human isoforms; isoforms as drug targets, enzymatic activity, catalytic mechanism, thermodynamics of protonation of the water molecule in the active site) -- 2) Thermal stabilities of all isoform CA catalytic domains -- Thermodynamics of inhibitor binding to CAs (incl. intrinsic thermodynamics - not mentioned important subject in most CA literature) -- 3) Comparison of methods to determine inhibitor binding to CAs (ITC, FTSA, enzymatic activity assays) -- 4) Chemical synthesis of CA inhibitors -- 5) X-ray crystallographic structures of CAs and their complexes with inhibitors -- 6) Antibodies against CAs
    Abstract: This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed
    Pages: XXVI, 353 p. 169 illus., 107 illus. in color. : online resource.
    ISBN: 9783030127800
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    Keywords: Medicine ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Methods and Models for Studying Immunosenescence -- Methods for studying human immunosenescence in tissues other than blood -- Mechanisms - Receptors and Signal Transduction -- Clinical Relevance in Disease States – Infection -- Modulation -- Nutrition
    Abstract: Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”
    Pages: 272 illus., 161 illus. in color. eReference. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9783319993751
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  • 47
    Unknown
    Dordrecht : Springer
    (Toxinology)  
    Keywords: Medicine ; Toxicology ; Pharmaceutical technology ; Life sciences ; Biochemistry ; Animal Physiology ; Biomedicine general ; Pharmacology/Toxicology ; Pharmaceutical Sciences/Technology ; Life Sciences, general ; Animal Biochemistry ; Animal Physiology ; Springer Nature Living Reference
    Abstract: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively
    Pages: Approx. 550 p. 30 illus., 15 illus. in color. : online resource.
    ISBN: 9789400767263
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    Keywords: Toxicology ; Medicine ; Pharmacology/Toxicology ; Molecular Medicine ; Biomedicine general ; Springer Nature Living Reference
    Description / Table of Contents: From the Contents: ABC Transporters -- Absorption -- Abstinence -- Abuse -- Abuse Liability -- Acamprosate -- BAC -- Balanced Placebo Design -- Barbital -- Barbiturates -- Basal Forebrain Cholinergic Neurons -- Behavioral Allocation Function -- Cabergoline -- Cachexia -- Caffeine -- Caffeine Withdrawal Syndrome -- Caffeinism -- cAMP -- DARPP-32 -- db/db Mouse -- D-cycloserine -- Decision Making -- Declarative and Non-Declarative Memory -- Declarative Memory -- Early Ventral Hippocampal Lesion Model -- Eating and Appetite -- Eating Disorder: Anorexia Nervosa -- Eating Disorders: Animal Models -- Eating Disorders: Binge-Eating -- Echolalia -- FAA -- Face Validity -- Facial Dysmorphology -- False Memory -- False Negative -- False Positive -- G protein-Coupled Receptors -- GABA -- GABAA Receptor -- GABAergic Transmission -- Gabapentin -- Galantamine -- Habit Reversal Therapy -- Habit Reversal Training -- Habituation -- Half-Life -- Hallucinations -- Hallucinogen Abuse -- IACUC -- ICD -- Idiopathic -- Imaging Mass Spectrometry -- Imipramine -- Impairment of Functioning; Measurement Scales -- Kappa-Opioid Agonists -- Kappa-Receptor -- Keratotic Lesion -- Ketamine -- Ketamine -- Khat -- L-Alpha-Acetyl-Methadol -- Lamotrigine -- Lanreotide -- Latent Inhibition -- Latin Square Design -- Laxatives -- Magnetic Resonance Imaging -- Major and Minor and Mixed Anxiety-Depressive Disorders -- Major Tranquilizer -- Mania -- MAO-B Inhibitor -- Mass Spectrometry -- N-Acetylcysteine -- Nafion -- Naloxone -- Naltrexone -- N-Arachidonylethanolamine -- Narcolepsy -- ob/ob Mouse -- Obsessions -- Obsessive-Compulsive Anxiety Disorders -- Occasion Setting with Drugs -- Octreotide -- Off-Label Use of Drugs -- P300 -- Pain -- Pain and Psychopharmacology -- Pair-Feeding -- Palatability -- Paliperidone -- qEEG -- QT Interval -- Quality of Life -- Quazepam -- Quetiapine -- Radial Arm Maze -- Radionuclide -- Radiopharmaceutical -- Radiotracer -- Randomized Controlled Trials -- Rapamycin -- Saporin -- Satiety -- Saturation Binding Curve -- Scalar Property -- Schedule I -- Schedule II -- Tachykinins -- Tachyphylaxis -- Tandospirone -- Tardive Dyskinesia -- Taste Reactivity Test -- Temazepam -- Ubiquitin-Proteasome System -- Ultrasonic -- Ultrasonic Vocalizations -- Ultrasonic Vocalizations -- Unblocking -- Unconditional Response -- Vaccination -- Vaccines and Drug-Specific Antibodies -- Vagus Nerve Stimulation -- Valproic Acid -- Values-Based Medicine -- Varenicline -- Wakefulness -- Water Maze -- Whole-Cell Recording -- Wisconsin Card Sorting Test -- Wisconsin General Test Apparatus -- Withdrawal Syndromes -- Yale-Brown Obsessive-Compulsive Scale -- Yohimbine -- Zaleplon -- Zero-Order Elimination Kinetics -- Ziprasidone -- Zolpidem -- Zonisamide -- Zopiclone
    Abstract: Psychopharmacology is the study of the effects of psychoactive drugs on the functioning of the central nervous system at all levels of analysis, thus embracing cognition, behaviour, psychological states, neurophysiology, neurochemistry, gene expression and molecular biology. It includes, as an integral part of its domain, the interaction of environmental and genetic factors with psychoactive drug action, their medicinal and social uses, and their abuse. The Encyclopedia of Psychopharmacology provides detailed information on psychopharmacology and its sub-disciplines, such as clinical psychopharmacology, molecular neuropsychopharmacology, behavioural pharmacology in laboratory animals, preclinical psychopharmacology, human experimental psychopharmacology. The wide-ranging entries in the Encyclopedia of Psychopharmacology are written by leading experts. They will provide basic and clinical scientists in academia as well as industry with valuable information about the field of psychopharmacology. Also people in related fields, students, teachers, and interested laypeople will benefit from the important and relevant information on the most recent developments of psychopharmacology. Entries will fall into several main categories: Methods, techniques and target systems (explaining nature of a technique and its uses and limitations) - Drugs and classes of drug (mainly describing effects and mechanisms of action) - Psychiatric states (explaining drugs used to treat them) - Miscellaneous currently interesting topics that do not fall within the above (e.g. cognitive enhancement, regulation and licensing, substance use in religious rituals)
    Pages: XLVI, 690 p. 206 illus., 80 illus. in color. : online resource.
    ISBN: 9783642277726
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