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  • Medicine.  (4,196)
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  • 1
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Human genetics. ; Medicine. ; Bioethics. ; Human Genetics. ; Medicine/Public Health, general. ; Bioethics.
    In: Springer Nature eBook
    Description / Table of Contents: Over the last decade, technical advances have allowed genomic testing which provides a great opportunity for diagnosis but also an increased chance of uncertain or unexpected findings. This book addresses many of the questions that arise in this context and summarizes the essential concepts in diagnostic genetic testing in an easy-to-read manner. It also covers some broad context for the practical and ethical implications of examining human DNA sequences. The book starts with a general introduction to the field, providing enough background to allow readers without any previous education in genetics to comprehend the material in the subsequent chapters. The main part explores differing aspects of human genetics and the wider implications of testing in these areas. The author covers not only single gene inheritance, but also genetic testing of cancers and how testing benefits the patients. Special emphasis is also given to the questions of genetics and identity. The concluding part then draws the main themes together and summarises the wider significance of genetics. It also explores the gap between promises made for the impact of advances in genetics, and the actual benefits to patients. The book is written for everyone interested to learn about the process of genetic testing and the broader implications. Moreover, it is aimed at health professionals with an interest in genetics, at students or scientific trainees looking for an introduction to diagnostic genetics, and at professionals in health policy or health journalism.
    Type of Medium: Online Resource
    Pages: XXII, 131 p. 17 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030855109
    Language: English
    Note: Genetic Testing, Some Themes and Some Basics -- Autosomal Dominant Inheriance and Huntington Disease -- Autosomal Recessive Inheritance and Cystic Fibrosis -- X-linked Inheritance: a Question of Gender -- Genetics Testing in Cancer -- DNA Testing, Genes and Identity -- Out of Sequence: Genome-Scale Testing -- DNA Testing: Pulling the Strands Together.
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  • 2
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    Subject(s): Medicine. ; Zoology. ; Biotechnology. ; Materials science. ; Plant science. ; Botany. ; Biomedicine, general. ; Zoology. ; Biotechnology. ; Materials Science, general. ; Plant Sciences.
    In: Springer Nature eBook
    Description / Table of Contents: This book discusses the fundamental concepts of the green synthesis of nanoparticles and presents the latest advances in this emerging field. Providing a comprehensive overview of developments related to nanoparticle synthesis using fungi, algae, bryophytes, pteridophytes, gymnosperms, monocotyledons, dicotyledonous (angiosperms) and animal systems, it also explores techniques for the characterization of these nanoparticles. Lastly, it reviews the applications and toxicity of biologically synthesized green nanoparticles. Given its scope, it is a valuable resource for students, researchers and policymakers working in the field of nanobiotechnology and nanoscience.
    Type of Medium: Online Resource
    Pages: XIII, 352 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811671067
    Language: English
    Note: 1 Green nanotechnology: an overview -- 2 The Nano-Domain -- 3 Tools and Techniques Used in Nanobiotechnology -- 4 Green Synthesis of Nanoparticles -- 5 Biological Synthesis of Nanoparticles: Bacteria -- 6 Biological Synthesis of Nanoparticles: Fungi -- 7 Biological Synthesis of Nanoparticles: Algae -- 8 Biological Synthesis of Nanoparticles: Bryophytes -- 9 Biological synthesis of nanoparticles: Pteridophytes -- 10 Biological Synthesis of Nanoparticles: Gymnosperms -- 11 Biological Synthesis of Nanoparticles: Angiosperms- Monocotyledons -- 12 Biological Synthesis of Nanoparticles: Dicotyledons -- 13 Biological Synthesis of Nanoparticles: Animal Systems -- 14 Applications of Biosynthesized Nanoparticles -- 15 Toxicity Aspects of Biologically Synthesized Nanoparticles -- 16 Nanobiotechnology: Present Status and Future Prospects.
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  • 3
    Subject(s): Chemistry. ; Biotechnology. ; Biomaterials. ; Veterinary medicine. ; Medicine. ; Biomaterials-Vaccines. ; Veterinary Science. ; Diseases.
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides a practical guide providing step-by-step protocol to explore vaccines for farm and companion animals, as well as for fish and insects. Divided into three volumes, Volume 2: Vaccines for Veterinary Diseases guides readers through veterinary vaccines, vaccines for poultry, vaccines for farm animals, and vaccines for veterinary parasites. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 2: Vaccines for Veterinary Diseases aims to be a useful practical guide to researchers to help further their study in this field. .
    Type of Medium: Online Resource
    Pages: XVI, 360 p. 41 illus., 38 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9781071618882
    Series Statement: Methods in Molecular Biology, 2411
    Language: English
    Note: Challenges in Veterinary Vaccine Development -- Mammalian Cell Culture as a Platform for Veterinary Vaccines -- Avian Paramyxoviruses as Vectors for Vaccine Development -- Reverse Genetics and its Usage in the Development of Vaccine against Poultry Diseases -- Use of a Ferret Model to Test Efficacy and Immunogenicity of Live Attenuated Mycobacterium avium Subspecies Paratuberculosis Vaccines -- Recombinant Escherichia coli Cell lysates as a low-cost alternative for vaccines against veterinary clostridial diseases -- Clostridium spp. Toxins: A Practical Guide for Expression and Characterization in Escherichia coli -- Macrophage Stimulation as a Useful Approach for Immunoscreening of Potential Vaccine Candidates against Toxoplasma gondii and Neospora caninum Infections -- Fundamentals of Fish Vaccination -- Teleost Fish as an Experimental Model for Vaccine Development -- Development of Nano-conjugated DNA Vaccine against Edwardsiellosis Disease in Fish -- Development and Evaluation of DNA Vaccine against Salmonid Alphavirus -- Novel Vaccine Development for Fish Culture Based on the Multiepitope Concept -- Testing Novel Inactivation Methods and Adjuvants for Vaccines against Streptococcus Agalactiae in Nile Tilapia Oreochromis niloticus -- Anti-tick Vaccines: Current Advances and Future Prospects -- Vaccines against Vector-Borne Diseases -- A quantum vaccinomics approach based on protein-protein interactions -- Screening for the ‘Achilles Heel’ of Hyalomma anatolicum Ticks by RNA Interference Technology and an Update on anti-Tick Vaccine Design -- Host Immunization with Recombinant Tick Antigen and Evaluation of Host Immune Response -- Fundamental Tick Vaccinomic Approach to Evade Host Autoimmune Reaction.
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  • 4
    Online Resource
    Online Resource
    New York, NY : Springer US
    Subject(s): Medicine. ; Agriculture. ; Biomedicine, general. ; Agriculture.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume explores practical procedures on the identification and quantification of pesticides in a variety of samples. Chapters guide the reader through methods and protocols for the extraction of pesticides from biological and non-biological samples, pitfalls in dosing techniques and structures identification, and also provide an overview of the problems that these pesticides cause in human populations. As part of the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of reagents and materials, step-by-step guides and reproducible lab protocols, as well as valuable tips on addressing common problems and avoiding known pitfalls. Authoritative and practical, Pesticide Toxicology is an ideal reference for academia, analysts, toxicologists, environmentalists, and health and industry professionals aiming to understand the associated risks and to limit the use of these substances and minimize their potential damage to human health and the environment.
    Type of Medium: Online Resource
    Pages: IX, 196 p. 40 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071619285
    Series Statement: Methods in Pharmacology and Toxicology,
    Language: English
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  • 5
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    Subject(s): Nutrition   . ; Food—Biotechnology. ; Medicine. ; Social sciences. ; Nutrition. ; Food Science. ; Medicine/Public Health, general. ; Social Sciences, general.
    In: Springer Nature eBook
    Description / Table of Contents: This Open Access auto-translation book demonstrates a time series of nutrition improvement in Japan since the introduction of nutrition sciences to Japan about 150 years ago. The chapters present the historical event where nutritional deficiency due to food shortage was improved in almost a century, by the introduction of nutrition policy and practices such as the "Nutrition Improvement Law". The book contributed to the construction of a longevity nation by resolving the double burden of malnutrition, which is a mixture of undernutrition and overnutrition and creating a social environment in which sustainable healthy diets can be accessed. This publication is designed mainly for nutrition specialists, nutritionists, nutrition administrators, medical doctors, pharmacists, nurses, physiotherapists, nutrition educators, cookers, nutrition volunteers, health and nutrition food developers, school lunch managers, and etc. Furthermore, students studying nutrition, teachers involved in the education and training of dietitians, and general consumers who are interested in nutrition, diets, and how to improve malnutrition, will find this book useful. Through this book, dietitians, nutrition volunteers, and consumers engaged in nutrition improvement can understand the significance of nutrition improvement and know specific methods. Young nutritionists who will study and research nutrition can learn the importance of nutrition and take pride in nutrition research. The government official who implements nutrition policy can know the concrete method of nutrition policy. Today, people around the world understand the importance of nutrition and are gaining international interest. However, malnutrition has not improved as much as expected. This book is an interesting way for everyone involved in nutrition to learn how to eradicate malnutrition from the world. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The present version has been revised technically and linguistically by the author in collaboration with Professor Emeritus Dr. Andrew R. Durkin of Indiana University.
    Type of Medium: Online Resource
    Pages: XI, 200 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811663161
    Language: English
    Note: Chapter 1. Preventing and Treating Disease with Nutrition -- Chapter 2. The Birth of Nutrition and the Systematization of Learning -- Chapter 3. History of Nutritional Improvement in Japan -- Chapter 4. Transformation to Human Nutrition -- Chapter 5. Team medicine and multidisciplinary education -- Chapter 6. Safe and appetizing patient meals -- Chapter 7. Nutrition for a 100 year life -- Chapter 8. Nutrition in Japan from an International Perspective -- Chapter 9. Cutting-edge science and technology and personalized nutritional advice -- Chapter 10. A Sustainable healthy diet -- Chapter 11. For those who hope to study health, medical care and welfare -- Chapter 12. Nutrition and diet in the future.
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  • 6
    Subject(s): Chemistry. ; Biotechnology. ; Biomaterials. ; Immunology. ; Medicine. ; Human physiology. ; Chemistry/Food Science, general. ; Biotechnology. ; Biomaterials. ; Immunology. ; Medicine/Public Health, general. ; Human Physiology.
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides a practical guide providing step-by-step protocol to design and develop vaccines for human diseases. Divided into three volumes, Volume 1: Vaccines for Human Diseases guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 1: Vaccines for Human Diseases aims to be a useful practical guide to researchers to help further their study in this field.
    Type of Medium: Online Resource
    Pages: XVIII, 711 p. 126 illus., 101 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9781071618844
    Series Statement: Methods in Molecular Biology, 2410
    Language: English
    Note: Challenges for Vaccinologists in the First Half of the Twenty First Century -- Principles in Immunology for the Design and Development of Vaccines -- Revisiting the Principles of Designing a Vaccine -- Status of COVID-19 Pandemic before the Administration of Vaccine -- mRNA Vaccines to Protect against Diseases -- Artificial Intelligence in Vaccine and Drug Design -- Vaccines Targeting Numerous Coronavirus Antigens, Ensuring Broader Global Population Coverage: Multi-Epitope and Multi-Patch Vaccines.-Use of Micro-computed Tomography to Visualize and Quantify COVID-19 Vaccine Efficiency in Free-breathing Hamsters -- Design of Replication-Competent VSV- and Ervebo-vectored Vaccines against SARS-CoV-2 -- CRISPR Engineering of Bacteriophage T4 to Design Vaccines against SARS-CoV-2 and Emerging Pathogens -- Techniques for Developing and Assessing Immune Responses Induced by Synthetic DNA Vaccines for Emerging Infectious Diseases -- Towards Determining the Epitopes of the Structural proteins of SARS-CoV-2 -- Development, production and characterization of hepatitis B subviral envelope particles as a third-generation vaccine -- Generation of CpG-Recoded Zika Virus Vaccine Candidates -- Salmonella Uptake into Gut-Associated Lymphoid Tissues: Implications for Targeted Mucosal Vaccine Design and Delivery -- Development of Human Recombinant Leptospirosis Vaccines -- Induction of T-cell Responses by Vaccination of a Streptococcus pneumoniae Whole Cell Vaccine -- Development of a Bacterial Nanoparticle Vaccine against Escherichia coli -- Construction of Novel Live Genetically Modified BCG Vaccine Candidates using Recombineering Tools -- An Update on Tuberculosis Vaccines -- Structure-Based Design of Diagnostics and Vaccines for Lyme Disease -- Development of a SONIX vaccine to protect against ehrlichiosis -- Development of the Anti-Leishmanial Vaccine -- In Silico Design of Recombinant Chimera T Cell Peptide Epitope Vaccines for Visceral Leishmaniasis -- Pre-clinical Assessment of the Immunogenicity of Experimental Leishmania Vaccines -- Production of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins -- A Fast-Track Phenotypic Characterization of Plasmodium falciparum Vaccine Antigens through Lyse-Reseal Erythrocytes Mediated Delivery (LyRED) of RNA Interference for Targeted Translational Repression -- Plasmodium falciparum Antigen Expression in Leishmania Parasite: A Way Forward for Live Attenuated Vaccine Development -- Molecular Characterization of a Vector-based Candidate Antigen using the 3'–RACE and Genome Walking Methods and In Silico Analysis of the Correspondent Protein for Vaccine Design and Development -- In vitro culture of Plasmodium falciparum for the Production of Mature Gametocytes for Performing Standard Membrane Feeding Assay and Infection of Anopheles spp. -- Plasmodium berghei Infection in BALB/c Mice Model as an Animal Model for Malaria Disease Research -- Standard membrane feeding assay for malaria transmission studies -- Generation of Tumor Targeted Dendritic Cell Vaccines with Improved Immunogenic and Migratory Phenotype -- Monocytes as a Cellular Vaccine Platform to Induce Anti-Tumor Immunity -- Beyond Sequencing: Prioritizing and Delivering Neoantigens for Cancer Vaccines -- Proteomics for Development of Food Allergy Vaccines -- Estimating Vaccine Potency using Antibody-based Competition Assays. .
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  • 7
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medical sciences. ; Medicine. ; Nursing. ; Neurology . ; Dentistry. ; Health Sciences. ; Clinical Medicine. ; Nursing. ; Neurology. ; Dentistry.
    In: Springer Nature eBook
    Description / Table of Contents: This short practical text uses a coaching approach to develop the reader’s interview skills. With increasing competition, doctors and healthcare professionals need to prepare well for success at interview. The author has successfully coached colleagues in the run-up to interviews using this approach. Readers will learn how to structure responses to reflect their personality, knowledge and experience. This approach encourages candidates to craft their responses in a compelling narrative that will help them stand out. Healthcare organisations are increasingly looking at assessment of values and behaviours as part of the recruitment process. This represents a shift from a more clinical competency-based approach and requires additional preparation for interview. This book will help coach clinicians to describe their own experience in this context. The author is a practicing clinician, coach and led development of a clinical leadership and quality improvement training program for doctors and dentists and training in the UK. This book is aimed at doctors and healthcare professionals in training positions and those moving to a new role.
    Type of Medium: Online Resource
    Pages: XV, 129 p. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031163210
    Language: English
    Note: Preparing your job application -- Pre Interview visits and interview format -- Clinical skills at interview -- Clinical leadership in healthcare -- Team work in healthcare -- Communication in healthcare -- Conflict in the healthcare environment -- Patient safety and clinical governance -- Quality improvement and innovation -- Education and research -- Challenges and opportunities.
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  • 8
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Biomechanics. ; Biotechnology. ; Biomedical engineering. ; Mechanical engineering. ; Control engineering. ; Robotics. ; Mechatronics. ; Medicine. ; Biomechanics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Mechanical Engineering. ; Control, Robotics, Mechatronics. ; Medicine/Public Health, general.
    In: Springer Nature eBook
    Description / Table of Contents: This textbook provides a thorough introduction and overview of the design and engineering of state-of-the-art prosthetics and assistive technologies. Innovations in prosthetics are increasingly made by cross-disciplinary thinking, and the author introduces the application of biomedical, mechanical, electrical, computer, and materials engineering principles to the design of artificial limbs. Coverage includes the fundamentals of biomechanics, biomechanical modeling and measurements, the basics of anatomy and physiology of limb defects, and the historical development of prosthetic design. This book stimulates the innovative thinking necessary for advancing limb restoration, and will be essential reading for students, as well as researchers, professional engineers and prosthetists, involved in the design and manufacture of artificial limbs. Learning enhanced by the exercises, including physical modeling with MATLAB and Simulink; Includes appendices with relevant equations and parameters for reference; Introduction to the design and engineering of prosthetics and assistive technologies.
    Type of Medium: Online Resource
    Pages: XIII, 224 p. 102 illus., 101 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030310776
    Language: English
    Note: Chapter 1. Introduction -- Chapter 2. Biomechanical Fundamentals -- Chapter 3. Biomechanical Measurements -- Chapter 4. Restoring the Lower Limb -- Chapter 5. Energetics of Gait -- Chapter 6. Human- Machine Interface -- Chapter 7. Prosthetic Control -- Chapter 8. Limb-Prosthetic Interface -- Chapter 9. Upper-limb Function -- Chapter 10. Advancing Prosthetic Designs.
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  • 9
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Immunology. ; Aging. ; Neurosciences. ; Nutrition   . ; Medicine. ; Immunology. ; Aging. ; Neurosciences. ; Nutrition. ; Medicine/Public Health, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.
    Type of Medium: Online Resource
    Pages: X, 199 p. 10 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030875329
    Series Statement: Healthy Ageing and Longevity, 16
    Language: English
    Note: Introduction -- Changes in primary and secondary lymphoid organs (bone marrow, thymus, lymph nodes, spleen) -- Immune barriers (skin, mucosa) -- Innate immunity (neutrophils, monocytes, macrophages) -- Adaptive immunity (T and B lymphocytes: naïve, effector and memory phenotypes and functions) -- ReIntroduction -- Changes in primary and secondary lymphoid organs (bone marrow, thymus, lymph nodes, spleen) -- Immune barriers (skin, mucosa) -- Innate immunity (neutrophils, monocytes, macrophages) -- Adaptive immunity (T and B lymphocytes: naïve, effector and memory phenotypes and functions) -- Regulatory/suppressive cells (Treg, MDSC) -- Infections - Flu, pneumonia, COVID -- Vaccine responses -- Cancer -- Neurodegenerative disease -- Lifestyle/Interventions(physical activity, nutrition, supplements). .
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  • 10
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Geriatrics. ; Medicine. ; Aging. ; Biochemistry. ; Geriatrics/Gerontology. ; Biomedicine, general. ; Aging. ; Biochemistry, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike. .
    Type of Medium: Online Resource
    Pages: XIV, 439 p. 57 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030849658
    Series Statement: Healthy Ageing and Longevity, 15
    Language: English
    Note: Redox dynamic homeostasis and aging -- Intrinsic and extrinsic factors associated with redox homeostasis and biological aging -- Chapter 3: Disturbed redox homeostasis in the aging brain -- Impaired redox homeostasis in cardiovascular aging -- Redox homeostasis status influences skeletal muscle aging.
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  • 11
    Subject(s): Medicine. ; Biotechnology. ; Materials science. ; Biomaterials. ; Biomedicine, general. ; Biotechnology. ; Materials Science, general. ; Biomaterials.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.
    Type of Medium: Online Resource
    Pages: IX, 376 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811627828
    Language: English
    Note: Chapter 1_Biosensing: Material, methods and principle of detection -- Chapter 2_Biosensing applications in the development of medical devices -- Chapter 3_Theranostics: basic principles -- Chapter 4_Material and technique advancements in the development of theranostic products -- Chapter 5_Medical device development strategies -- Chapter 6_Research aspects for the development of medical devices -- Chapter 7_Biosensor-based commercialized point-of-care devices -- Chapter 8_Medical devices in clinical set up -- Chapter 9_Clinical validation of medical devices -- Chapter 10_Regulatory steps involved in the validation of medical devices -- Chapter 11_Protocol for registration process of point-of-care device at FDA or equivalent agencies -- Chapter 12_Opportunities and challenges in medical device development -- Chapter 13_Prospective journey of the research idea from laboratory to the user in the clinic. .
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  • 12
    Subject(s): Chemistry. ; Medicine. ; Chemistry/Food Science, general. ; Medicine/Public Health, general.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume explores techniques in clinical proteomics, an emerging discipline aimed at deciphering the molecular mechanisms underlying the progression of diseases and at identifying new biomarkers and therapeutic targets to expand the physicians’ toolbox for precision medicine-based patient care. From sample processing to multi-omics approaches, the book provides straight-forward protocols on a wide array of vital areas of study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Proteomics: Methods and Protocols serves as an ideal guide for researchers working to expand upon the knowledge base needed to push forward toward a more personalized version of medicine.
    Type of Medium: Online Resource
    Pages: XIII, 264 p. 42 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071619360
    Series Statement: Methods in Molecular Biology, 2420
    Language: English
    Note: Bile Processing Protocol for Improved Proteomic Analysis -- MS-Based Extracellular Vesicles (EVs) Analysis: An Application to Helminth-Secreted EVs -- Proteomic Profiling of Cerebrospinal Fluid by 16-Plex TMT-Based Mass Spectrometry -- Data-Independent Acquisition Mass Spectrometry-Based Deep Proteome Analysis for Hydrophobic Proteins from Dried Blood Spots Enriched by Sodium Carbonate Precipitation -- Sample Processing for Metaproteomic Analysis of Human Gut Microbiota -- Mass Spectrometry-Based Analytical Strategy for Single Cell Proteomics -- Lysine Acetylation Stoichiometry Analysis at the Proteome Level -- Implementation of Clinical Phosphoproteomics and Proteomics for Personalized Medicine -- pH/Acetonitrile-Gradient-Reversed-Phase Fractionation of Enriched Hyper-Citrullinated Library in Combination with LC–MS/MS Analysis for Confident Identification of Citrullinated Peptides -- Purification of HLA Immunopeptidomes from Human Thymus -- Generation of HLA Allele-Specific Spectral Libraries to Identify and Quantify Immunopeptidomes by SWATH/DIA-MS -- Immunopeptidomic Analysis of the Phosphopeptidome Displayed by Hla Class I Molecules -- Development of a Standardized MRM Method for Quantification of One Carbon Metabolism Enzymes -- Molecular Histology Analysis of Cryopreserved Tissue Using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS) -- The Human Protein Atlas and Antibody-Based Tissue Profiling in Clinical Proteomics -- Microbial Identification in the Clinical Microbiology Laboratory Using MALDI-TOF-MS -- Combining Electron Microscopy (EM) and Cross-Linking Mass Spectrometry (XL-MS) for Structural Characterization of Protein Complexes -- Accurate Prediction of Protein Sequences for Proteogenomics Data Integration.
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  • 13
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Pharmacy. ; Public health. ; Medicine. ; Medical care. ; Medical economics. ; Medicine—Research. ; Biology—Research. ; Pharmacy. ; Public Health. ; Clinical Medicine. ; Health Care. ; Health Economics. ; Biomedical Research.
    In: Springer Nature eBook
    Description / Table of Contents: Medicine itself is sick. We hardly understand any disease and therefore need to chronically treat symptoms but not the causes. Consequently, drugs and other therapies help only very few patients; yet we are pumping more and more money into our healthcare system without any added value and neglect prevention. Thus, the internationally renowned physician scientist, Harald H.H.W. Schmidt, MD, PhD, PharmD, professor at Maastricht University, predicts the end of medicine as we know it. On a positive note, digitization will radically change healthcare and lead to one of the greatest socioeconomic revolutions of mankind. He is one of the pioneers of "systems medicine", a complete redefinition of what we call a "disease", how we organize medicine and how we use Big Data to heal rather than treat, and to prevent rather than cure. In this book the author first proves the deep crisis of medicine, and then also describes how medicine will become more precise, more preventive, safer and, surprisingly, more affordable. “Dr. Harald Schmidt convincingly explains the limitations in the current practice of medicine and the need for big data and a systems approach.” Ferid Murad MD, PhD, Nobel Laureate in Medicine 1998 "Visionary, provocative, and full of insights. Professor Schmidt gives a unique and authoritative perspective to the past, present and future of medical science and clinical practice. And all presented in such an inimitable style." Prof. Robert F. W. Moulds, MBBS PhD FRACP, Former Dean Royal Melbourne Hospital Clinical School of the University of Melbourne, Australia The translation was performed with the help of artificial intelligence (machine translation by the service DeepL.com). Subsequent human revision including updating of each chapter was carried out mainly with a view to internationalization of the content, so that the book reads differently from a simple translation in terms of style and timeliness.
    Type of Medium: Online Resource
    Pages: XIV, 291 p. 34 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030952938
    Language: English
    Note: Prologue: Many questions, no answers -- Part 1: Crisis, what crisis...? -- 1. Too Late -- 2. Don’t Rely on Your Prescription -- 3. Chronic Disease? -- 4. No Prevention -- 5. Male Plus Low Income = Double Whammy -- 6. False Incentives -- 7. The End of Big Pharma -- 8. Research Not for Patients -- 9. Organ-Based Medicine -- 10. Interjection 1: How Healthy Do You Want to Be?.-Part 2: The Medicine of the Future -- 11. Re-Discover the Whole Patient -- 12. Research for patients -- 13. Know Your Genes -- 14. Outnumbered -- 15. Your Exposome -- 16. Big Data Medicine -- 17. Healed -- 18. Well-Tech -- 19. Interjection 2: Superhumans -- Part 3: The Future has Begun... -- 20. Self-diagnosis -- 21. Self-therapy -- 22. Your Digital Twin. Epilogue: Nobody Is Sick Anymore -- Appendix 1: Special Page 1 -- Appendix 2: Special Page 2. .
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  • 14
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Toxicology. ; Pain medicine. ; Medicine. ; Toxicology. ; Pain Medicine. ; Medical Toxicology. ; Clinical Medicine.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 16 pain categories with an evidence-based literature review on each pain disorder, illustrative figures showing anatomy and techniques Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. The new edition is updated with all the new findings since the explosion in research and literature since 2015. New chapters on the history and pain in dentistry round out the update. Botulinum Toxin Treatment of Pain Disorders provides an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.
    Type of Medium: Online Resource
    Pages: XVII, 430 p. 66 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030996505
    Language: English
    Note: Molecular Structure, Mode of Action and Immunology of Botulinum Neurotoxins -- Analgesic effects of botulinum neurotoxins: Data from animal studies -- Neuropathic Pain (NP) -- Migraine and Other Primary Headaches -- Botulinum Neurotoxins and Chronic Low Back Pain -- Botulinum Toxin Treatment of Plantar Fasciitis (Plantar Fasciopathy) -- History of Botulinum Treatment for Pain.-Botulinum Toxin Treatment of Piriformis Syndrome -- Botulinum Toxin Treatment of Myofascial Pain Syndrome and Fibromyalgia -- Pelvic and Urogenital Pain -- Botulinum Toxin Treatment of Chronic Facial pain: Trigeminal Neuralgia, Temporo-Mandibular Disorders and Dental-Related Pain -- Botulinum Neurotoxins for Relief of Pain Associated with Spasticity -- Treatment of Dystonic Pain with Botulinum Neurotoxins -- Botulinum Toxin Therapy for Prevention of Post-surgical Pain -- Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- Botulinum Toxins for Treatment of Cancer-related, Post-radiation, Post-surgical and End of Life Pain -- Botulinum Neurotoxin Treatment of Unusual and Rare Painful Disorders -- Pain in Dentistry -- Future Prospects of Pain Treatment with Botulinum Neurotoxins.
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  • 15
    Subject(s): Cancer research. ; Stem cells. ; Medicine. ; Pharmacology. ; Cancer Research. ; Stem Cells. ; Biomedicine, general. ; Pharmacology/Toxicology.
    In: Springer Nature eBook
    Description / Table of Contents: The detailed volume aims to provide a comprehensive hands-on manual covering all the techniques involved in the cellular and molecular identification and characterization of both normal hematopoietic and leukemic stem cells, both from human patients and from mouse models of human leukemia. The book also covers the most frequently used experimental approaches for the generation of such stem cell-based models of human leukemia. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Leukemia Stem Cells: Methods and Protocols serves as an ideal guide for researchers, both expert and novice, seeking to further our knowledge of this vital avenue of cancer research.
    Type of Medium: Online Resource
    Pages: XIII, 479 p. 87 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071608104
    Series Statement: Methods in Molecular Biology, 2185
    Language: English
    Note: Introduction and Classification of Leukemias -- Leukemia Stem Cells: Concept and Implications -- Leukemia Stem Cell Drug Discovery -- Analysis and Isolation of Mouse Leukemic Stem Cells -- Mass Cytometry of Hematopoietic Cells -- PCR Technology to Identify Minimal Residual Disease -- Next-Generation Sequencing Technology to Identify Minimal Residual Disease in Lymphoid Malignancies -- Genomic Inverse PCR for Screening of Preleukemic Cells in Newborns (GIPFEL Technology) -- Single-Cell Transcriptomic Analysis of Hematopoietic Cells -- In-Depth Mass Spectrometry-Based Single-Cell and Nanoscale Proteomics -- In Vivo Clonal Analysis of Aged Hematopoietic Stem Cells: Single-Cell Transplantation -- Experimental Competitive Bone Marrow Transplant Assays -- Human T-ALL Xenografts -- An Experimental and Computational Protocol to Study Cell Proliferation in Human Acute Myeloid Leukemia Xenografts -- Leukemic Stem Cell Culture in Cytokine-Free Medium -- Ex Vivo Expansion of Adult Hematopoietic Stem and Progenitor Cells with Valproic Acid -- Isolation, Culture, and Manipulation of Human Cord Blood Progenitors -- Lentiviral Transduction for Optimal LSC/HSC Manipulation -- Characterizing the In Vivo Role of Candidate Leukemia Stem Cell Genes -- Clonal Analysis of Patient-Derived Samples Using Cellular Barcodes -- Arrayed Molecular Barcoding of Leukemic Stem Cells -- In Vivo Generation of Leukemic Stem Cells by HSC Targeting by Transgenesis -- In Situ Hematopoietic Stem Cell Imaging -- A Genome-Editing System for Therapeutical Targeting of Stem Cells -- Method for the Generation of Induced Hematopoietic Stem Cells -- Modeling Leukemia Stem Cells with Patient-Derived Induced Pluripotent Stem Cells -- High Content Imaging to Phenotype Human Primary and iPSC-Derived Cells -- Bioinformatic Methods to Identify Mutational Signatures in Cancer.
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  • 16
    Subject(s): Environmental chemistry. ; Environmental health. ; Pollution. ; Environmental monitoring. ; Analytical chemistry. ; Medicine. ; Environmental Chemistry. ; Environmental Health. ; Pollution, general. ; Monitoring/Environmental Analysis. ; Analytical Chemistry. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book presents recent reviews on the occurrence, analysis, toxicity and remediation of pesticides in biological systems such as fish, chickens, water, soil and food.
    Type of Medium: Online Resource
    Pages: XV, 373 p. 96 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030547127
    Series Statement: Sustainable Agriculture Reviews, 47
    Language: English
    Note: Chapter 1 Determination of Pesticide Residues in Fish -- Chapter 2 Analysis of Pesticide Residues in Pollen and Dairy Products -- Chapter 3 Monitoring and Evaluation of Pesticide Residues in Aquatic Systems -- Chapter 4 Pyrethroid and Residues in Chickens and Poultry Litter -- Chapter 5 Extraction Procedures and Chromatography of Pesticides Residues in Strawberries -- Chapter 6 Non-extractable Pesticide Residues in Soils -- Chapter 7 Pyrethroids Metabolites in Human Urine Samples -- Chapter 8 Remediation of Pesticide in Water -- Chapter 9 Strategy for the Inspection of Pesticide Residues in Food and Agriculture -- Chapter 10 Toxic Effects of Pesticides on Avifauna Inhabiting Wetlands -- Chapter 11 Analysis of Pesticide Residues in Biotic Matrices.
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  • 17
    Subject(s): Pharmacology. ; Medicine. ; Pharmacy. ; Pharmacology/Toxicology. ; Biomedicine, general. ; Drug Safety and Pharmacovigilance.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.
    Type of Medium: Online Resource
    Pages: XII, 271 p. 4 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071612330
    Series Statement: Springer Protocols Handbooks,
    Language: English
    Note: Overview -- Cell Culture Assays -- Phytochemical Analysis -- Preclinical Drug Dose Calculation -- Toxicology Studies (In Vitro and In Vivo) -- Standard Procedure for Anesthesia in Preclinical Experiments -- General Considerations and Collection of Animal Blood -- Animal Experiments on the Cardiovascular System -- Animal Experiments on Ulcerative Colitis -- Experiments on Anti-Bacterial Activities -- Experiments on Anti-Fungal Activities -- Animal Experiment on Wound Healing Activity -- Animal Experiments of Anti-inflammatory Activities -- Animal Experiment on Anti-Nociceptive Activities -- Experiments on Anti-Oxidant Activities -- Animal Experiments on Hepatoprotective Activities -- Animal Experiments on Anti-Diarrheal Activities -- Animal Experiments on Central Nervous System (CNS) -- Experiments on Anti-Cancer Activities (In Vitro and In Vivo) -- Animal Experiments on Anti-Diabetic Activities -- Animal Experiments on Gastric Ulcer -- Protein Extraction and Western Blot Analysis -- Gel Electrophoresis and PCR Amplification -- Molecular Docking Methods for Drug Design.
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  • 18
    Subject(s): Medicine. ; Pharmacology. ; Biotechnology. ; Regenerative medicine. ; Tissue engineering. ; Biomedicine, general. ; Pharmacology/Toxicology. ; Biotechnology. ; Regenerative Medicine/Tissue Engineering.
    In: Springer Nature eBook
    Description / Table of Contents: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations. The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 174 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030574567
    Language: English
    Note: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.
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  • 19
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Genetics. ; Medicine. ; Cell biology. ; Human genetics. ; Genetics and Genomics. ; Biomedicine, general. ; Cell Biology. ; Human Genetics.
    In: Springer Nature eBook
    Description / Table of Contents: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease.
    Type of Medium: Online Resource
    Pages: XII, 215 p. 81 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030686703
    Series Statement: Learning Materials in Biosciences,
    Language: English
    Note: Biology of Chromatin -- Chromatin Dynamics -- Cellular Memory -- Dosage Compensation Systems -- Genomic Imprinting -- RNA-based Mechanisms of Gene Silencing -- Regeneration and Reprogramming -- Epigenetics and Cancer -- Epigenetics and Metabolism.
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  • 20
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medicine. ; Artificial intelligence. ; Bioinformatics. ; Biomedicine, general. ; Artificial Intelligence. ; Bioinformatics.
    In: Springer Nature eBook
    Description / Table of Contents: This book is the first overview on Deep Learning (DL) for biomedical data analysis. It surveys the most recent techniques and approaches in this field, with both a broad coverage and enough depth to be of practical use to working professionals. This book offers enough fundamental and technical information on these techniques, approaches and the related problems without overcrowding the reader's head. It presents the results of the latest investigations in the field of DL for biomedical data analysis. The techniques and approaches presented in this book deal with the most important and/or the newest topics encountered in this field. They combine fundamental theory of Artificial Intelligence (AI), Machine Learning (ML) and DL with practical applications in Biology and Medicine. Certainly, the list of topics covered in this book is not exhaustive but these topics will shed light on the implications of the presented techniques and approaches on other topics in biomedical data analysis. The book finds a balance between theoretical and practical coverage of a wide range of issues in the field of biomedical data analysis, thanks to DL. The few published books on DL for biomedical data analysis either focus on specific topics or lack technical depth. The chapters presented in this book were selected for quality and relevance. The book also presents experiments that provide qualitative and quantitative overviews in the field of biomedical data analysis. The reader will require some familiarity with AI, ML and DL and will learn about techniques and approaches that deal with the most important and/or the newest topics encountered in the field of DL for biomedical data analysis. He/she will discover both the fundamentals behind DL techniques and approaches, and their applications on biomedical data. This book can also serve as a reference book for graduate courses in Bioinformatics, AI, ML and DL. The book aims not only at professional researchers and practitioners but also graduate students, senior undergraduate students and young researchers. This book will certainly show the way to new techniques and approaches to make new discoveries.
    Type of Medium: Online Resource
    Pages: VI, 359 p. 130 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716769
    Language: English
    Note: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.
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  • 21
    Subject(s): Medicine. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.
    Type of Medium: Online Resource
    Pages: XV, 468 p. 92 illus., 60 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9781071612705
    Series Statement: Methods in Molecular Biology, 2277
    Language: English
    Note: Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease -- Mitochondrial Transplantation for Ischemia Reperfusion Injury -- Quantitatively Controlled Intercellular Mitochondrial Transfer by Cell Fusion-Based Method Using a Microfluidic Device -- Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable Into Human Mitochondria -- Drug Discovery Assay to Identify Modulators of the Mitochondrial Ca2+ Uniporter -- Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice -- Electron Attachment to Isolated Molecules as a Probe To Understand Mitochondrial Reductive Processes -- Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation -- Assessment of the Effects of Drugs on Mitochondrial Respiration -- The Ndufs4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging -- Suborganellar Localisation of Mitochondrial Proteins and Transcripts in Human Cells -- In vivo Assessment of Mitochondrial Oxygen Consumption -- Update of Mitochondrial Network Analysis by Imaging: Proof of Technique in Schizophrenia -- Heterologous Inferential Analysis (HIA) and other Emerging Concepts In Understanding Mitochondrial Variation in Pathogenesis: There is no More Low Hanging Fruit -- Accurate Measurement of Cellular and Cell-Free Circulating Mitochondrial DNA Content from Human Blood Samples Using Real Time Quantitative PCR -- Measurement of Mitochondrial Respiration in Platelets -- Isolation and Electron Microscopic Analysis of Liver Cancer Cell Mitochondria -- Assessment of Mitochondrial Reactive Oxygen Species and Redox Regulation in Stem Cells -- Single Cell Approaches for Studying the Role of Mitochondrial DNA in Neurodegenerative Disease -- A New Method for Sequencing the Mitochondrial Genome by Using Long Read Technology -- Mitochondrial DNA as a Sensitive Biomarker of UV-induced Cellular Damage in Human Skin -- Isolation of Mitochondria-associated ER Membranes (MAMs), Synaptic MAMs and Glycosphingolipid Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells -- Mitochondrial Diagnostics: A Discovery-Based Biochemical Platform for Phenotyping Human Peripheral Blood Cell Mitochondria -- Bioenergetic Profiling Of Human Pluripotent Stem Cells -- Integrative Methods for Studying Cardiac Energetics -- Isolation of Mitochondria from Retinal Pigment Epithelial Cell Cultures and an Application Of High Resolution Respirometric Assay (XFe96 Seahorse assay) -- The Isolation and Deep Sequencing of Mitochondrial DNA -- Ultrastructure of the Mitochondria-Associated Membranes in Human Tumor Specimens. .
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  • 22
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medicine. ; Health administration. ; Public health. ; Health promotion. ; Medicine/Public Health, general. ; Health Administration. ; Public Health. ; Health Promotion and Disease Prevention.
    In: Springer Nature eBook
    Description / Table of Contents: The landmark 2010 Patient Protection and Affordable Care Act (ACA), “Obamacare,” was the largest healthcare policy innovation in the United States in 50 years, and it has generated strong opinions and debate across public, political, and policy arenas. Examining the innovation of the ACA as a health policy experiment, The Affordable Care Act as a National Experiment was published by Springer in 2014. Now, six years later, following an election year in which the ACA remained hotly debated, this second edition further examines the history, lessons, and impact of this ground-breaking legislation. Written by national healthcare policy leaders involved in the ACA’s creation and implementation, this book addresses questions around patient protection under the ACA, delves into Medicaid expansion and insurance reform, assesses the Supreme Court review of the ACA, and sheds light on the related social determinants of health. It also provides informative stories of the uninsured. It discusses the stabilization of the ACA, and concludes with a summary of potential next steps and the push for universal healthcare. This second edition further underscores that to improve access to medical care and the public’s health, we must innovate – and to innovate is to experiment. It makes clear that the ACA is a “translational medical research” experiment – an experiment aimed at translating best medical knowledge into improvements in health. And it shows that, like any medical experiment, its results will point to needed next steps. We hope this text becomes an essential resource for healthcare providers, policy makers, and academics.
    Type of Medium: Online Resource
    Pages: IX, 128 p. 25 illus., 22 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030667269
    Language: English
    Note: Introduction: An Overview of the ACA as a National Experiment -- A Decade of ACA: The Successes, Unfinished Work, and Impact of the Affordable Care Act -- Patient Protections in the Affordable Care Act -- Beyond Coverage and Controversy: The ACA’s Distinctly American Approach to Healthcare Coverage and Reform -- Medicaid Expansion and Insurance Reform Under the Affordable Care Act: The New New Federalism of Health Policy or the Same Old Same Old? -- Policies Designed to Achieve a Data-Driven Learning Healthcare System: A Decade of Progress and Future Directions -- The Healthcare Message Wars -- The Role of the Supreme Court in Shaping the Affordable Care Act -- The Center for Medicare and Medicaid Innovation – A Decade of Experimentation and Continued Evolution -- Social Determinants: Working Upstream to Solve Health Problems Before They Start -- Stories of the Uninsured -- Can Fifty-One Laboratories Cure What Ails the Individual Health Insurance Markets? -- What’s Next: The Push For Universal Healthcare.
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  • 23
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Physiology. ; Cardiology. ; Regenerative medicine. ; Tissue engineering. ; Medicine. ; Physiology. ; Cardiology. ; Regenerative Medicine/Tissue Engineering. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon. .
    Type of Medium: Online Resource
    Pages: XXVII, 345 p. 44 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030855369
    Language: English
    Note: Section I: Normal Cardiomyocyte and its Growth -- 1. Structure and Function of Cardiomyocyte -- 2. Development of Cardiomyocyte -- 3. Cell Cycle Regulation in Cardiomyocytes -- 4. Cardiac Fibroblast and Cardiomyocyte Growth -- 5. Role of Endocardium and Epicardium in Generation of Cardiomyocytes -- Cardiomyocytes in the Mammalian Adult Heart -- 7. Energy Metabolism in Cardiomyocytes -- Section II: Cardiomyocyte Responses 8. Response of Cardiomyocytes to Mechanical Stress -- Cardiomyocyte Responses to Hormones 10. Sequelae of Genetic Defects in Cardiomyocytes -- 11. Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart -- Section III: Cardiomyocyte Aging and Death -- 12. Cardiomyocyte Senescence -- 13. Mechanisms of Cardiomyocyte Death -- 14. Cardiomyocyte Response to Ischemic Injury -- 15. Cardiomyocytes in Heart Failure -- Section IV: Cardiomyocyte Regeneration -- 16. Endogenous Mechanisms for Cardiomyocyte Regeneration -- 17. Mechanisms to Induce Cardiomyocyte Proliferation -- 18. Cell Sources of Cardiomyocytes for Heart Repair -- 19. Reprograming Fibroblasts for Cardiomyocytes and Progenitors -- Section V: Translational Aspects of Cardiomyocyte Biology -- 20. Clinical Translation of Discoveries in Cardiomyocyte Biology.
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  • 24
    Subject(s): Food—Biotechnology. ; Agriculture. ; Plant science. ; Botany. ; Social sciences. ; Medicine. ; Geography. ; Food Science. ; Agriculture. ; Plant Sciences. ; Social Sciences, general. ; Medicine/Public Health, general. ; Geography, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book discusses different fruit crops and provides first-hand information on the nutritional composition of commercially important, as well as unexplored fruits, which are grown in Jammu, Kashmir and Ladakh. A detailed nutritional profile of each fruit is presented in the book. The potential health implications against cardiovascular diseases, diabetes, carcinoma, oxidative damage, asthma, aging and cognition are discussed and explained. Besides, nutritional composition and medicinal implications, origin, morphology, taxonomy and production scenarios of unexplored, as well as commercially important fruits, have also been highlighted in the book. This book will be of interest to students and researchers involved in agricultural sciences, food science, nutrition and the Indian medicine system.
    Type of Medium: Online Resource
    Pages: XVII, 336 p. 115 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030755027
    Language: English
    Note: Introduction-Classification of Fruits and Significance of Horticulture in J&K -- Apple (Pyrus Malus) -- Pear (Pyrus communis) -- Quince (Cydonia oblonga) -- Cherry (Prunus cerasus) -- Fig (Ficus carica) -- Apricot (Prunus armeniaca) -- Grapes (Vitis vinifera) -- Olive (Olea europaea L) -- Pomegranate (Punica granatum) -- Kiwifruit (Actinidia deliciosa) -- Ber (Ziziphus mauritiana) -- Plum (Prunus domestica) -- Litchi (Litchi chinensis) -- Anola (Emblica officinalis) -- Peach (Prunus persica) -- Strawberry (F. ananassa) -- Citrus fruits -- Mango (Mangifera indica) -- Guava (Psidium guajava) -- Walnut (Juglans regia) -- Almond (Prunus dulcis) -- Pecan (Carya illinoenis) -- Mulberry (M. rubra) -- Seabuckthorn (Hippophae Tibetana) -- Socio-economic aspects of horticultural crops grown under highland Himalayan regions. .
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  • 25
    Subject(s): Medicine. ; Environment. ; Biology—Technique. ; Biomedicine, general. ; Environment, general. ; Biological Techniques.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.
    Type of Medium: Online Resource
    Pages: XIII, 366 p. 74 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071615140
    Series Statement: Methods in Molecular Biology, 2326
    Language: English
    Note: Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example -- High-Throughput Measurement for Toxic Effects of Metal Mixtures in Caenorhabditis elegans -- Evaluations of Environmental Pollutants-Induced Mitochondrial Toxicity Using Caenorhabditis elegans as a Model System -- Methods to Assay the Behavior of Drosophila melanogaster for Toxicity Study -- Investigating the Joint Effects of Pesticides and Ultraviolet-B Radiation in Xenopus laevis and Other Amphibians -- Identification of Stable Reference Genes for Toxicogenomic and Gene Expression Analysis -- Semi-Quantitative RT-PCR: An Effective Method to Explore the Regulation of Gene Transcription Level Affected by Environmental Pollutants -- Employing Multiple New Neurobiological Methods to Investigate Environmental Neurotoxicology in Mice -- Analyses of Epigenetic Modification in Environmental Pollutants-Induced Neurotoxicity -- The Application of Omics Technologies in the Research of Neurotoxicology -- Flow Cytofluorometric Analysis of Molecular Mechanisms of Premature Red Blood Cell Death -- Practical Methods and Technologies in Environmental Epidemiology -- In Ovo Early-in-Life Inhalation Exposure to Gas/Aerosol with a Chicken Embryo Model -- DNA Damage in Liver Cells of the Tilapia Fish Oreochromis mossambicus Larva Induced by the Insecticide Cyantraniliprole at Sublethal Doses During Chronic Exposure -- Impact of Nanoparticles on Plant Growth, Development, and Biomass -- Biochemical and Physiological Toxicity of Nanoparticles in Plant -- Determination of Oxidative Stress and Antioxidant Enzyme Activity for Physiological Phenotyping During Heavy Metal Exposure -- Comprehensive Phytotoxicity Assessment Protocol for Engineered Nanomaterials -- Detection of Cadmium Toxicity in Plant -- Mutagenicity Evaluation of Nanoparticles by the Ames Assay -- Dispersive Solid Phase Extraction of Multiresidue Pesticides in Food and Water Samples -- Quantitative Analysis of Multiresidue Pesticides Using Gas Chromatography/Mass Spectrometry -- Determination of the N-Nitroso Compounds in Mouse Following RDX Exposure -- Determination of Metal Content in Drosophila melanogaster During Metal Exposure -- Microplastics: A Review of Methodology for Sampling and Characterizing Environmental and Biological Samples.
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  • 26
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Health care management. ; Health services administration. ; Medicine. ; Health Care Management. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book aims to disseminate and review the latest interdisciplinary medical knowledge to provide information on best clinical practice for difficult-to-treat conditions. The chapters address various aspects and approaches to the management of medical conditions that are not fully understood. This is exemplified by complex immune and inflammatory interactions in cancer development and survival-prolonging repeat surgery for pulmonary metastases or advances in craniotomy techniques for intracranial hemorrhage. Other chapters address the quality of life of patients after pyeloplasty, parathyroidectomy, or physically debilitating ankylosing spondylitis. Additional chapters address primary ciliopathies, a group of unclear genetic disorders affecting airway function, and dysfunctional airway remodeling underlying proinflammatory molecular mechanisms. The last few chapters address advances in the use of artificial intelligence for health management and in-silico experiments, which is gaining importance in a variety of difficult-to-control conditions, such as endoprosthetic fixation in orthopedics. The book is dedicated to expanding knowledge in medical care by facilitating communication and discussion across medical disciplines. It is intended for clinical specialists, general practitioners, researchers, and members of all healthcare professions.
    Type of Medium: Online Resource
    Pages: VI, 135 p. 20 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777425
    Series Statement: Clinical and Experimental Biomedicine, 1335
    Language: English
    Note: Artificial Intelligence in the Health Care System: An Overview -- Complex interaction among immune, inflammatory, and carcinogenic mechanisms in the head and neck squamous cell carcinoma -- Outcomes of Repeat Pulmonary Metastasectomy: An Evidence Review -- Quality of Life of Patients after Laparoscopic Pyeloplasty Due to Ureteropelvic Junction Obstruction: A Long-Term Observation -- Causes and Effects of Introducing Surgery Safety Checklist: A review -- Benefit of Biological Drugs for Quality of Life in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis of Clinical Trials -- Changes of Motile Ciliary Phenotype in Patients with Primary Ciliopathies -- Effects of Inhalation of STIM-Orai Antagonist SKF 96365 on Ovalbumin-Induced Airway Remodeling in Guinea Pigs -- In Silico Analysis of Bone Tension during Fixation of the Medial Malleolus Fracture after Ankle Joint Endoprosthesis -- Effects of Physical Activity at High Altitude on Hormonal Profiles in Foreign Trekkers and Indigenous Nepalese Porters -- Influence of Parathyroidectomy on Sleep Quality in Primary Hyperparathyroidism -- Mini Craniotomy in the Management of Supra-Tentorial Spontaneous Intracranial Hemorrhage; a Single-Center Outcome of the Minimally Invasive Treatment.
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  • 27
    Subject(s): Veterinary medicine. ; Animal physiology. ; Medicine. ; Cancer research. ; Immunology. ; Veterinary Medicine/Veterinary Science. ; Animal Physiology. ; Biomedicine, general. ; Cancer Research. ; Immunology.
    In: Springer Nature eBook
    Description / Table of Contents: This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice. Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control. Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy. Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum.
    Type of Medium: Online Resource
    Pages: XII, 352 p. 59 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030806682
    Language: English
    Note: Part 1: Technology and Science of Electroporation: Fundamentals -- Electroporation: Technology and Science -- Electrodes and electric field distribution in clinical practice -- Part 2: Therapeutic Applications with Electroporation in Veterinary Oncology Practice -- Electrochemotherapy in Veterinary Oncology -- Treating Mast Cell Tumors with Electrochemotherapy -- Electrochemotherapy for the treatment of transitional cell carcinoma in dogs -- Calcium electroporation in veterinary medicine -- Irreversible Electroporation Applications -- Electrochemotherapy as a multi-modality component of cancer treatment- combinations with surgery, radiation therapy and chemotherapy -- Part 3: Gene-Electrotransfer and Immunotherapy Applications with Electroporation -- Gene Electrotransfer -- Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer -- Interleukin-12 gene electrotransfer in veterinary oncology -- Canine Melanoma and Osteosarcoma Immunotherapy by means of in vivo DNA Electroporation -- Part 4: Evolution of the Field and New Applications with Electroporation-Based Treatments: Outlook -- Electrodes for Unique Anatomical Access in Electroporation -- New Electrodes and Treatment Planning for deep-seated and intraluminal localized tumors -- Advancing Electroporation Systems.
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  • 28
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medicine. ; Psychotherapy. ; Counseling. ; School management and organization. ; School administration. ; Career education. ; Biomedicine, general. ; Psychotherapy and Counseling. ; Administration, Organization and Leadership. ; Career Skills.
    In: Springer Nature eBook
    Description / Table of Contents: Pursuing a career in biomedical research can be daunting, considering the stiffer competition and uncertain career prospects in academia. This book summarizes career advice gathered during in-depth interviews with 106 biomedical scientists who lead their own laboratories. The participating principal investigators are from 44 research institutions in 11 countries. This book is unique in that it provides a glimpse into the mindset of principal investigators. Here, the reader will learn about common thought patterns and values, as well as the range of opinions and ways of thinking to be found among a large group of active principal investigators – without having to read more than a hundred individual autobiographies. The book will benefit all PhD students who want to learn more about their supervisor’s mindset in order to successfully complete their projects. It can help freshly graduated PhDs planning to pursue an academic career, and MDs contemplating a career in research, to decide whether they truly want to embark on this path. Lastly, it can offer young principal investigators a source of inspiration on how to succeed and achieve their goals.
    Type of Medium: Online Resource
    Pages: XIX, 209 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030855710
    Language: English
    Note: Chapter 1: “Carving Your Own Path” – shaping your scientific identity -- Chapter 2: The Two Cornerstones of Academic Research: Writing Grant Applications and Publications -- Chapter 3: Setting up a Successful Research Group -- Chapter 4: Leading Your Research Group as a Principal Investigator -- Chapter 5: The Daily Work of Principal Investigators -- Chapter 6: Dealing with Failure and Stress in Academic Research -- Chapter 7: Thoughts of Principal Investigators about Work, Science, and Themselves -- Chapter 8: Under the Hood – Common Thinking Patterns of Principal Investigators -- Chapter 9: Epilogue -- Chapter 10: Methods.
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  • 29
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    Subject(s): Medicine. ; Parasitology. ; Medical microbiology. ; Virology. ; Biomedicine, general. ; Parasitology. ; Medical Microbiology. ; Virology.
    In: Springer Nature eBook
    Description / Table of Contents: This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.
    Type of Medium: Online Resource
    Pages: XIX, 542 p. 78 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811606915
    Language: English
    Note: Chapter 1. Geno-Informatics for Prediction of Virulence and Drug Resistance in Bacterial Pathogens -- Chapter 2. Next Generation Sequencing: Challenges and Opportunities in Tuberculosis Research -- Chapter 3. Deciphering the role of epigenetic reprogramming in host-pathogen interactions -- Chapter 4. Genomic evidence provides the understanding of SARS-CoV-2 composition, divergence and diagnosis -- Chapter 5. Importance of Next Generation Sequencing in Viral Diagnostics -- Chapter 6. Bioinformatics application in CoVID19 -- Chapter 7. Emerging Transcriptomics approaches to decipher Mycobacterial complexities -- Chapter 8. Microarrays: A road map to uncover host pathogen interactions -- Chapter 9. Transcriptional Approach in the Identification of Drug Targets in Candida spp -- Chapter 10. Non-Coding RNA profiling: Potential Application in Infectious Diseases -- Chapter 11. RNA-seq analysis strategies to understand viral pathogenesis -- Chapter 12. Various Transcriptomic approaches & their applications to study small non-coding RNAs in Dengue and other viruses -- Chapter 13. Transcriptomic Approaches in Understanding Sars-COV-2 Infection -- Chapter 14. miRNA target prediction: Overview and applications -- Chapter 15. A Glimpse into Peptidomic Approach -- Chapter 16. Molecular mechanism of action of antimicrobial agents against clinically important human pathogens: A proteomic approach -- Chapter 17. Exploration of the mycobacterial proteome in the pathogenesis of TB: A perspective -- Chapter 18. Pathogenesis of Staphylococcus aureus and proteomic strategies for the identification of drug targets -- Chapter 19. Proteomics in the study of Host-Pathogen interactions -- Chapter 20. Significance of post-translational modifications in Apicomplexan parasites -- Chapter 21. An introduction to computational pipelines for analyzing untargeted metabolomics data for Leishmaniasis -- Chapter 22. Metabolomics: PromisingTool to Study Disease Biomarkers and Host-Pathogen Interactions -- Chapter 23. Lipidomics to study the role of lipid droplets in host-pathogen interactions -- Chapter 24. Lipid structure, function and lipidomic applications -- Chapter 25. Nanoparticles as Therapeutic Nanocargos affecting Epigenome of Microbial Biofilms -- Chapter 26. Malaria in the era of OMICS: Challenges and Way forward -- Chapter 27. Omics Approaches for Infectious Diseases -- Chapter 28. Pathogen-Omics: challenges and prospects in research and clinical settings.
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  • 30
    Subject(s): Cell biology. ; Stem cells. ; Medicine. ; Cell Biology. ; Stem Cells. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eleventh volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030719258
    Series Statement: Cell Biology and Translational Medicine, 1312
    Language: English
    Note: Induced pluripotent stem cell derived human lung organoids to map and treat the SARS-CoV2 infections in vitro -- Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges -- Functions of Mesenchymal Stem Cells in Cardiac Repair -- Cardiac Progenitor Cells -- Cardiac Immunology: a new era for immune cells in the heart -- Conventional and Alternative Mesenchymal Stem Cell Therapies for the Treatment of Diabetes -- Mesenchymal stem cells: The past present and future -- Extracellular vesicles therapeutics in regenerative medicine -- Exosomes as part of the human adipose-derived stem cells secretome- opening new perspectives for cell-free regenerative applications -- A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke.
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  • 31
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Cell biology. ; Stem cells. ; Medicine. ; Cell Biology. ; Stem Cells. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the twelfth volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 188 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030719333
    Series Statement: Cell Biology and Translational Medicine, 1326
    Language: English
    Note: Immune dysregulation and recurring mutations in myelodysplastic syndromes pathogenesis -- Stem Cell Aging and Regenerative Medicine -- Potential of Chimeric Antigen Receptor T-cells in cancer therapy -- Drug sensitivity and drug repurposing platform for cancer precision medicine -- Role and regulation of Lin28 in progenitor cells during central nervous system development -- Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspective -- Kaempferol induce cell death and sensitizes human head and neck squamous cell carcinoma cell lines to cisplatin -- A comprehensive approach to Urticaria: from clinical presentation to modern biological treatments through pathogenesis -- The potentials and pitfalls of using adult stem cells in cancer treatment -- The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis.
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  • 32
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Cell biology. ; Immunology. ; Medicine. ; Cell Biology. ; Immunology. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: XI, 521 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851682
    Series Statement: Heat Shock Proteins, 22
    Language: English
    Note: 1.Extracellular Vesicle-associated Moonlighting Proteins: HSP and Metalloproteinases -- 2.Heat Shock Proteins and Periodontitis ― Crossreaction between Bacterial and Human HSP in Periodontal Infection Linking with Cardiovascular Diseases -- 3.Protective Role of Heat Shock Proteins during Neurodegeneration in Parkinson's Disease -- 4.HSP Stimulation on Macrophages and Dendritic Cells Activates Innate Immune System -- 5.Heat Shock Factor 1 and its Small Molecule Modulators with Therapeutic Potential -- 6.Heat Shock Proteins, a Key Modulator of Neuroinflammation in Alzheimer’s Disease -- 7.Role of Heat Shock Factor 1 in HIV -- 8.Heat Shock Protein and Cancer Based Therapies -- 9.Effects of Heat Shock Protein 70 kDa in Allergic Airway Inflammation -- 10.Role of Heat Shock Factor 1 in Neural Development and Disorders -- 11.Small Heat Shock Proteins in Inflammatory Diseases -- 12.Overview of Multifaceted Role and Significance of Heat Shock Proteins during Inflammation, Apoptosis and Other Diseases -- 13.Heat Shock Proteins as Target Autoantigens in Autoimmune Rheumatic Diseases -- 14.DNAJA3, a Co-chaperone in Development and Tumorigenesis -- 15.Therapeutic Potential of Heat Shock Proteins in Human Inflammation/Autoimmune Skin Diseases: Future Directions -- 16.Role of HSP in the Pathogenesis of Age-related Inflammatory Diseases -- 17.Heat Shock Factor Network in Kidney Diseases -- 18.Binary Role of Heat Shock Proteins in Cancer Immunotherapy: A Detailed Perspective -- 19.The role of heat shock proteins in reproductive functions -- 20.Heat shock proteins 70 in cellular stress: fight or flight -- 21.Indispensable role of protein turnover in autophagy, apoptosis and ubiquitination pathways -- 22.Heat Shock Proteins in Leishmania Parasites -- 23.HSF1 in RNA Polymerase II Promoter-Proximal Pausing and HSP70 Transcription -- 24.Induction of HSPA1A and Autophagy by SARS-CoV-2: Combined Potential Influence on Pregnancy Outcome.
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  • 33
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    Subject(s): Medicine. ; Medical microbiology. ; Microbiology. ; Cancer research. ; Immunology. ; Biomedicine, general. ; Medical Microbiology. ; Microbiology. ; Cancer Research. ; Immunology.
    In: Springer Nature eBook
    Description / Table of Contents: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science. This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
    Type of Medium: Online Resource
    Pages: XXIII, 296 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811631566
    Language: English
    Note: Chapter 1_Significance of microbiome on human healthcare -- Chapter 2_Animal models for microbiome studies -- Chapter 3_Bioinformatics tools for analyzing microbiomes -- Chapter 4_Modulation of Systemic Immune Responses through genital, skin, and oral microbiota.-Chapter 5_Role of microbiome in development of immune system -- Chapter 6_Understanding the interplay between host immune-microbiome interactions -- Chapter 7_Overview on human gut microbiome and its role in immunomodulation -- Chapter 8_Cancer microbiome and immunotherapy: Understanding the complexity between microbes, immunity, and cancer -- Chapter 9_Dynamics of Respiratory Microbiome in lung dysbiosis -- Chapter 10_Microbiome Therapeutics: Emerging concepts and challenges -- Chapter 11_Intestinal Microbiome and Health -- Chapter 12_Macromolecule signalling mediating inflammation and immune system interaction -- Chapter 13_Microbiome-immune homeostasis and their involvement in cancer immunotherapy -- Chapter 14_Challenges and future prospects in the microbiome intervention in human health and disease.
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  • 34
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medicine. ; Biophysics. ; Biological physics. ; Chemistry. ; Chemical engineering. ; Biomedicine, general. ; Biological and Medical Physics, Biophysics. ; Chemistry/Food Science, general. ; Industrial Chemistry/Chemical Engineering.
    In: Springer Nature eBook
    Description / Table of Contents: This textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.
    Type of Medium: Online Resource
    Pages: XVIII, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764692
    Series Statement: Learning Materials in Biosciences,
    Language: English
    Note: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.
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  • 35
    Subject(s): Medicine. ; Pharmacology. ; Environment. ; Biomedicine, general. ; Pharmacology/Toxicology. ; Environment, general.
    In: Springer Nature eBook
    Description / Table of Contents: The book covers the area of ‘Nanotoxicology’ but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.Nanotoxicology in Humans and the Environment is written for researchers in nanotoxicology in academia, industry, government, and research students. Given the rapid development, the maturing of the discipline and its importance in current regulation and industry development (eg REACH, TSCA), the book is very timely.
    Type of Medium: Online Resource
    Pages: V, 259 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798086
    Series Statement: Molecular and Integrative Toxicology,
    Language: English
    Note: Overview of Nanotoxicology in Humans and the Environment: Developments.-The potential adverse effects of engineered nanomaterial exposure to human health following pulmonary, oral and dermal exposure @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:3 0 0 0 1 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US; mso-fareast-language:ZH-CN;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:11.0pt; mso-ansi-font-size:11.0pt; mso-bidi-font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; 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  • 36
    Subject(s): Cell biology. ; Stem cells. ; Medicine. ; Cell Biology. ; Stem Cells. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 14th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 224 p. 3 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030804923
    Series Statement: Cell Biology and Translational Medicine, 1347
    Language: English
    Note: Recent Advances in the Generation of β-cells from Induced Pluripotent Stem Cells As a Potential Cure for Diabetes Mellitus -- Differentiated cells derived from hematopoietic stem cells and their applications in translational medicine -- Organoids in Tissue Transplantation -- Aldo keto reductases AKR1B1 and AKR1B10 in cancer: molecular mechanisms and signaling networks -- Bilayer Scaffolds for Interface Tissue Engineering and regenerative medicine: A Systematic Review -- Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson’s Disease (ARPD): PLA2G6 and Other Gene Loci -- Stem Cell Applications In Lysosomal Storage Disorders: Progress And Ongoing Challenges -- Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers -- Telomere length and oxidative stress in patients with St-elevation and Non-St-elevation myocardial infarction -- Eosinophils as major player in Type 2 inflammation: autoimmunity and beyond.
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  • 37
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medicine. ; Respiratory organs—Diseases. ; Physiology. ; Immunology. ; Biomedicine, general. ; Pneumology/Respiratory System. ; Physiology. ; Immunology.
    In: Springer Nature eBook
    Description / Table of Contents: This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lung transplant patients. A new physiotherapeutic approach of treating key myofascial trigger points in low-back pain appears highly beneficial in reducing patients’ disability, advancing physiotherapy of this overwhelming condition. Finally, other chapters consider ways to streamline medical management to increase the number of physicians and their availability for patients, a particularly sensitive issue in the current COVID-19 pandemic. The dissemination of clinical knowledge about high-risk and hardly controllable conditions is an inalienable part of progress in medical practice. The book is a resource for clinical specialists, general practitioners, and allied healthcare professionals.
    Type of Medium: Online Resource
    Pages: VI, 101 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030702069
    Series Statement: Clinical and Experimental Biomedicine, 1324
    Language: English
    Note: Overload of Medical Documentation: A Disincentive for Healthcare Professionals -- Epidemiologic Benefits of Pneumococcal Vaccine Introduction into Preventive Vaccination Programs -- Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly -- Influenza A (H1N1) and Respiratory Syncytial Virus (RSV) Coinfection in a Newborn Child: A Case Report -- Thoracic Manifestation of Granulomatosis with Polyangiitis: A Case Report -- The Natural Course of Impaired Fasting Glucose -- Oleosins: A Short Allergy Review -- Shortage of Physicians: A Critical Review -- Fluid Therapy in Patients Undergoing Abdominal Surgery: A Bumpy Road Towards Individualized Management -- Manual Pressure Release and Low-Grade Electrical Peripheral Receptor Stimulation in Nonspecific Low Back Pain: A Randomized Controlled Trial -- Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate. Cognitive Function After Lung Transplantation.
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  • 38
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Subject(s): Medicine. ; Biomedical engineering. ; Bioinformatics. ; Biotechnology. ; Optical data processing. ; Biomedicine, general. ; Biomedical Engineering and Bioengineering. ; Bioinformatics. ; Biotechnology. ; Computer Imaging, Vision, Pattern Recognition and Graphics.
    In: Springer Nature eBook
    Description / Table of Contents: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. In this volume, there are chapters which examine forensic and historical visualisation techniques and digital reconstruction, ultrasound, virtual learning resources and patient utilised software and hardware. The use of HoloLens as a disruptive technology is discussed as well as historical items as a feature in a modern medical curriculum. It concludes with a fascinating chapter on pulse extraction from facial videos. All in all, this volume has something for everyone whether that is faculty, students, clinicians and forensic practitioners, patients, or simply having an interest in one or more of these areas.
    Type of Medium: Online Resource
    Pages: XV, 202 p. 68 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030611255
    Series Statement: Advances in Experimental Medicine and Biology, 1317
    Language: English
    Note: Chapter 1. Pair-Matching Digital 3D Models Of Temporomandibular Fragments Using Mesh-To-Mesh Value Comparison And Implications For Commingled Human Remain Assemblages (Alana S. Acuff, Mara A. Karell, Konstantinos E. Spanakis, And Elena F. Kranioti) -- Chapter 2. Forensic Recreation And Visual Representation Of Greek Orthodox Church Saint, Eftichios of Crete (Nectarios Vidakis, Markos Petousis, Despoina Nathena, Elena F. Kranioti, Andreas Manios) -- Chapter 3. Virtual Trauma Analysis Of The 19th Century Severed Head Of The Greek Outlaw Stavrou (Elena F. Kranioti, Nikos Tsiatis, Kristina Frandson, Maria Stefanidou, Konstantinos Moraitis) -- Chapter 4. Using Computed Tomography (CT) Data To Build 3D Resources For Forensic Craniofacial Identification (Terrie Simmons-Ehrhardt, Catyana R.S. Falsetti, Anthony B. Falsetti) -- Chapter 5. Instructional Design Of Virtual Learning Resources For Anatomy Education (Nicolette S. Birbara, Nalini Pather) -- Chapter 6. Implementation Of Ultrasound In Anatomy Education (Claire Smith And Seb Barfoot) -- Chapter 7. What The Tech? The Management Of Neurological Dysfunction Through The Use Of Digital Technology (Caitlin Carswell And Paul M. Rea) -- Chapter 8. Teaching With Disruptive Technology: The Use Of Augmented, Virtual, And Mixed Reality (Hololens) For Disease Education (Zane Stromberga, Charlotte Phelps, Jessica Smith & Christian Moro) -- Chapter 9. “Inform the Head, Give Dexterity to the Hand, Familiarise the Heart”: Seeing and Using Digitised Eighteenth-Century Specimens in a Modern Medical Curriculum (Frances Osis) -- Chapter 10. Contact-Free Pulse Signal Extraction From Human Face Videos: A Review And New Optimised Filtering Approach (Muhammad Waqar, Reyer Zwiggelaar And Bernard Tiddeman).
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  • 39
    Subject(s): Parasitology. ; Microbiology. ; Medicine. ; Parasitology. ; Microbiology. ; Medicine/Public Health, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms. This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners.
    Type of Medium: Online Resource
    Pages: XI, 284 p. 42 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607455
    Language: English
    Note: 1 Introduction to Bacteria and Acute Infections -- 2 Quorum sensing -- 3 Bacteria and Biofilms as Natural Inhabitants of our Body -- 4 Biofilms and Acute and Chronic Infections -- 5 Bacterial and Biofilms in Chronic Infections and Nosocomial Diseases -- 6 Immune Response to Biofilm -- 7 Biofilm in Medical Appliances -- 8 Biofilm and Antimicrobial Resistance -- 9 Inhibition of Biofilm Formation -- 10 Novel and Future Treatment Strategies for Biofilm Associated Infections -- 11 Biofilm- the Unknown Armour in the Arsenal of Bacteria: A Case Study.
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  • 40
    Subject(s): Bioinformatics. ; Health care management. ; Health services administration. ; Medicine. ; Artificial intelligence. ; Bioinformatics. ; Health Care Management. ; Medicine/Public Health, general. ; Artificial Intelligence.
    In: Springer Nature eBook
    Description / Table of Contents: This book reviews the application of artificial intelligence and machine learning in healthcare. It discusses integrating the principles of computer science, life science, and statistics incorporated into statistical models using existing data, discovering patterns in data to extract the information, and predicting the changes and diseases based on this data and models. The initial chapters of the book cover the practical applications of artificial intelligence for disease prognosis & management. Further, the role of artificial intelligence and machine learning is discussed with reference to specific diseases like diabetes mellitus, cancer, mycobacterium tuberculosis, and Covid-19. The chapters provide working examples on how different types of healthcare data can be used to develop models and predict diseases using machine learning and artificial intelligence. The book also touches upon precision medicine, personalized medicine, and transfer learning, with the real examples. Further, it also discusses the use of machine learning and artificial intelligence for visualization, prediction, detection, and diagnosis of Covid -19. This book is a valuable source of information for programmers, healthcare professionals, and researchers interested in understanding the applications of artificial intelligence and machine learning in healthcare.
    Type of Medium: Online Resource
    Pages: XIX, 228 p. 119 illus., 88 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811608117
    Language: English
    Note: Chapter 1_Big Data Analytics and AI for Healthcare -- Chapter 2_Genetics with Big Data and AI -- Chapter 3_AI and Big Data for next-generation sequencing -- Chapter 4_Artificial Intelligence for Computational Biology -- Chapter 5_Artificial intelligence and machine learning in clinical development -- Chapter 6_Big data analytics for personalized medicine -- Chapter 7_Generating and Managing Healthcare data with AI -- Chapter 8_Big Data and Artificial Intelligence for diseases -- Chapter 9_Artificial Intelligence and Big Data for Public Health -- Chapter 10_Biasness in Healthcare Big Data and Computational Algorithms -- Chapter 11_AI and ML in Healthcare: An Ethical perspective.
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  • 41
    Subject(s): Medicine. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. The chapters "Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury", "Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism" and "Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVI, 412 p. 166 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030482381
    Series Statement: Advances in Experimental Medicine and Biology, 1269
    Language: English
    Note: Part I. Oxygen Metabolism and Health Monitoring -- Chronic Ketosis Modulates HIF1α Mediated Inflammatory Response in Rat Brain -- Event Related NIRS and EEG Analysis for Mental Stress Monitoring -- Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability -- Updated Evaluation of Cholesterol’s Influence of Oxygen Permeability -- Systems biology model of cerebral oxygen delivery and metabolism during therapeutic hypothermia: application to the piglet model -- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model -- Two consecutive invasive surgeries utilizing Zymogen Protein C (ZPC) that enhanced patient safety and reduced costs -- Scanning Tissue-Oxygen Needle-Probe -- Transcranial photobiomodulation of clearance of beta-amyloid from the mouse brain: the effects on meningeal lymphatic drainage and blood oxygen saturation of the brain -- Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome -- Part II. Oxygen Measurement and Modeling -- Online assessment of hemodynamics in suctioned volume of biological tissue by the embedded Near-infrared Spectroscopy sensor -- Skeletal Muscle Deoxygenation and its Relationship to Aerobic Capacity During Early and Late Stages of Aging -- Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MBO2 Desaturation During Exercise -- Relationship between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation -- Relationship between the Borg Scale Rating of Perceived Exertion and Leg Muscle Deoxygenation during Incremental Exercise in Healthy Adults -- Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients in Chronic Heart Failure -- Reduced Scattering Coefficient During Incremental Exercise is Constant without being Affected by Changes in Muscle Oxygenation or Hemodynamics -- Changes in the laterality of oxygenation in the prefrontal cortex and premotor area during a 20-min moderate-intensity cycling exercise -- Relationship Between Decrease of Oxygenation During Incremental Exercise, Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis -- Cerebral Oxygenation Dynamics during Incremental Exercise: Comparison of Arm Cranking and Leg Cycling -- Localization of Deep of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near Infrared Optical Tomography: A Numerical Case Study -- Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling -- Part III. Tumor Oxygenation and Modeling -- Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis -- Functional Impact of Acidosis-regulated MicroRNAs on the Migration and Adhesion of Tumor Cells -- Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo -- An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A -- Keynote Lecture - The Warburg Effect: Historical Dogma versus Current Rationale -- The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as well as Adhesion of NCI-H358 Lung Cancer Cells -- Assessment of the probability of tumor control for prescribed doses based on imaging of oxygen partial pressure -- On the feasibility of Pulse Wave Velocity Imaging for remote assessment of physiological functions -- Mechanisms of sound-induced opening of the blood-brain barrier -- Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury -- Cerebral Spreading Depression Transient Disruption of Cross Frequency Coupling in the Rat Brain: Preliminary Observations -- Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not all Subjects React the Same -- Changes in Prefrontal Cortex Asymmetry Due to Standing Loading in Stroke Patients Measured by NIRS -- Parasympathetic Nervous Activity Associated with Discoordination between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea -- The Changes in Brain Oxygenation during Transcranial Alternating Current Stimulation as Consequences of Traumatic Brain Injury: A Near-infrared Spectroscopy Study -- Error Evaluation for Automated Diameter Measurements of Cerebral Capillaries Captured with Two-Photon Laser Scanning Fluorescence Microscopy -- Potential Biomarker for Triple Negative Breast Cancer Invasiveness by Optical Redox Imaging -- Optical redox imaging differentiates triple-negative breast cancer subtypes -- Oxygen-sensing Paramagnetic Probes for Clinical Oximetry -- Evaluation of the Quality of Chest Compression with Oxy-hemoglobin Level by Near-infrared Spectroscopy in a Rat Asphyxia Cardiac Arrest Model -- Altered Behavioural Performance in the Neuron-specific HIF-1 and HIF-2 deficient mice following Chronic Hypoxic Exposure -- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model -- Addition of Drag Reducing Polymers to Colloid Resuscitation Fluid Enhances Cerebral Microcirculation and Tissue Oxygenation after Traumatic Brain Injury Complicated by Hemorrhagic Shock -- Effects of 20-minute intensive exercise on subjects with different working memory bases -- Supine cycling exercise enhances cerebral oxygenation of motor-related areas in healthy male volunteers -- Keynote Lecture - What is the Meaning of an Oxygen Measurement? Analysis of methods purporting to measure oxygen in targeted tissues -- Part IV. Brain Oxygenation and Function -- Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in A Rat Asphyxia Cardiac Arrest Model -- Effect of 3-Day and 21-Day Hypoxic Preconditioning on Recovery following Cerebral Ischemia in Rats -- Time Series Tracking of Cerebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated in vivo Two-Photon Microscopy -- Environmental Enrichment Improved Cognitive Performance in Mice under Normoxia and Hypoxia -- Effect of Prolonged Pressure on Hemodynamics of Sacral Tissues Assessed by Diffuse Optical Imaging: A Pilot Study -- In-phantom Validation of Time-Domain Near-Infrared Optical Tomograph Pioneer for Imaging Brain Hypoxia and Hemorrhage -- Online Non-invasive Assessment of Human Brain Death by Near-infrared Spectroscopy with Protocol of O2 Inspiration -- Not removing the glossy white cover from adhesive INVOS neonatal sensors affects the oxygenation measurement -- Probe design optimization for time-domain NIROT ‘Pioneer’ system for imaging the oxygenation of the preterm brain -- Effect of blood flow on hemoglobin and myoglobin oxygenation in contracting muscle using near infrared spectroscopy -- Magnetoresistance Properties of Red Blood Cells in Plasma Combined with Several Magnetic Beads Passing Two Cu Electrodes -- Measurement of Tissue Oxygen as a Novel Approach to Optimizing Red Blood Cell Quality Assessment -- Prox-1 and Hif-1a Genes Expression of Primo Vessel in Rabbit’s Lymphatic Vessel -- On the Feasibility of Pulse Wave Velocity Imaging for Remote Assessment of Physiological Functions -- Index.
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  • 42
    Subject(s): Cancer research. ; Immunology. ; Medicine. ; Cancer Research. ; Immunology. ; Biomedicine, general.
    In: Springer Nature eBook
    Description / Table of Contents: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
    Type of Medium: Online Resource
    Pages: XII, 369 p. 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030633691
    Language: English
    Note: Epidimology of colorectal cancer -- Colorectal cancer: A model for the study of cancer immunology -- Impact of Covid-19 Pandemic on Gastro Intestinal Cancer Patients: An Emphasis on Colorectal Cancer -- Potential role of NMR and MRI in colon cancer -- Role of micro-RNA in-situ hybridization in colon cancer diagnosis -- Role of epigenetics in colorectal cancer -- Exosomal biomarkers in colorectal cancer -- Biomarkers as putative therapeutic targets in colorectal cancer -- Proteins involved in colorectal cancer: Identification strategies and possible roles -- Short-chain fatty acids as therapeutic agents in colon malignancies -- Targeting of angiogenesis for colorectal cancer therapy -- Anti‐inflammatory molecular mechanism and contribution of drug transport molecules in colorectal cancer cells -- Emerging role of circulating tumour DNA in treatment response prognosis in colon cancer -- Immuno-modulating mediators of colon cancer as immunotherapeutic: mechanism and potential -- Immune checkpoint inhibitors as armor for targeted immunotherapy of colorectal cancer -- Examining the role of the MACC1 gene in colorectal cancer metastasis -- Index.
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  • 43
    Subject(s): Medicine. ; Demography. ; Business. ; Management science. ; Health informatics. ; Health promotion. ; Graphic design. ; Medicine/Public Health, general. ; Demography. ; Business and Management, general. ; Health Informatics. ; Health Promotion and Disease Prevention. ; Interaction Design.
    In: Springer Nature eBook
    Description / Table of Contents: This book describes the multidisciplinary approach needed to tackle better aging. Aging populations are one of the 21st century’s biggest challenges. National health systems are forced to adapt in order to provide adequate and affordable care. Innovation, driven by digital technology, is a key to improving quality of life and encouraging healthy living. Well-designed technology keeps people empowered, independent, and mobile; however, despite widespread adoption of ICT in day-to-day life, digital health technologies have yet to catch on. To this end, technology needs to be effective, usable, cheap,