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  • Reproducibility of Results  (324)
  • Nature Publishing Group (NPG)  (324)
  • Hindawi
  • Sage Publications
  • American Institute of Physics (AIP)
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  • 1
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldacre, Ben -- England -- Nature. 2016 Feb 4;530(7588):7. doi: 10.1038/530007a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842021" target="_blank"〉PubMed〈/a〉
    Keywords: Bias (Epidemiology) ; Clinical Trials as Topic/*methods/*standards ; *Editorial Policies ; Evidence-Based Medicine/methods/standards ; Guidelines as Topic ; Humans ; Periodicals as Topic/*standards ; Reproducibility of Results ; Research Report/*standards ; Treatment Outcome
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karve, Shraddha Madhav -- Mangalam, Madhur -- England -- Nature. 2016 Mar 17;531(7594):305. doi: 10.1038/531305d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Indian Institute of Science Education and Research, Pune, India. ; University of Georgia, Athens, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26983529" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Motivation ; *Publishing ; Reproducibility of Results ; Research/*standards ; Research Personnel/psychology/*standards ; Time Factors
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chi, Kelly Rae -- England -- Nature. 2016 Apr 14;532(7598):269-71. doi: 10.1038/532269a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27075102" target="_blank"〉PubMed〈/a〉
    Keywords: Aged, 80 and over ; Biopsy/economics/*methods ; Blood Platelets/cytology ; DNA Mutational Analysis/economics/methods ; DNA, Neoplasm/*blood/genetics ; Drug Resistance, Neoplasm/genetics ; Exosomes/genetics ; Female ; Humans ; Neoplasm Metastasis/diagnosis/genetics ; Neoplasm Recurrence, Local/blood/diagnosis/genetics ; Neoplasms/*blood/*diagnosis/drug therapy/genetics ; Neoplastic Cells, Circulating/metabolism ; Phagocytosis ; Polymerase Chain Reaction ; Reproducibility of Results ; Sensitivity and Specificity
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- England -- Nature. 2016 Feb 18;530(7590):264. doi: 10.1038/nature.2016.19335.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26887470" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed/*analysis/standards ; Animal Nutritional Physiological Phenomena ; Animals ; *Animals, Laboratory/genetics/microbiology ; Confounding Factors (Epidemiology) ; Diet/standards/veterinary ; *Environment ; Female ; Gastrointestinal Microbiome ; *Housing, Animal ; Humans ; Lighting ; Male ; Mice ; Mice, Inbred Strains ; Models, Animal ; Reproducibility of Results ; *Research Design/standards
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2016-01-28
    Description: Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour. An understanding of the regulatory circuitry governing the transcriptional landscapes of medulloblastoma subgroups, and how this relates to their respective developmental origins, is lacking. Here, using H3K27ac and BRD4 chromatin immunoprecipitation followed by sequencing (ChIP-seq) coupled with tissue-matched DNA methylation and transcriptome data, we describe the active cis-regulatory landscape across 28 primary medulloblastoma specimens. Analysis of differentially regulated enhancers and super-enhancers reinforced inter-subgroup heterogeneity and revealed novel, clinically relevant insights into medulloblastoma biology. Computational reconstruction of core regulatory circuitry identified a master set of transcription factors, validated by ChIP-seq, that is responsible for subgroup divergence, and implicates candidate cells of origin for Group 4. Our integrated analysis of enhancer elements in a large series of primary tumour samples reveals insights into cis-regulatory architecture, unrecognized dependencies, and cellular origins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Charles Y -- Erkek, Serap -- Tong, Yiai -- Yin, Linlin -- Federation, Alexander J -- Zapatka, Marc -- Haldipur, Parthiv -- Kawauchi, Daisuke -- Risch, Thomas -- Warnatz, Hans-Jorg -- Worst, Barbara C -- Ju, Bensheng -- Orr, Brent A -- Zeid, Rhamy -- Polaski, Donald R -- Segura-Wang, Maia -- Waszak, Sebastian M -- Jones, David T W -- Kool, Marcel -- Hovestadt, Volker -- Buchhalter, Ivo -- Sieber, Laura -- Johann, Pascal -- Chavez, Lukas -- Groschel, Stefan -- Ryzhova, Marina -- Korshunov, Andrey -- Chen, Wenbiao -- Chizhikov, Victor V -- Millen, Kathleen J -- Amstislavskiy, Vyacheslav -- Lehrach, Hans -- Yaspo, Marie-Laure -- Eils, Roland -- Lichter, Peter -- Korbel, Jan O -- Pfister, Stefan M -- Bradner, James E -- Northcott, Paul A -- England -- Nature. 2016 Feb 4;530(7588):57-62. doi: 10.1038/nature16546. Epub 2016 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Oncology, Dana Farber Cancer Institute (DFCI), Boston, Massachusetts 02215, USA. ; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany. ; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ; Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. ; Department of Molecular Physiology &Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA. ; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98105, USA. ; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. ; Department of Bone Marrow Transplantation &Cellular Therapy, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. ; Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. ; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. ; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ; Department of Translational Oncology, NCT Heidelberg, 69120 Heidelberg, Germany. ; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 125047 Moscow, Russia. ; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), and Department of Neuropathology University Hospital, 69120 Heidelberg, Germany. ; Department of Anatomy and Neurobiology, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA. ; Department of Pediatrics, Genetics Division, University of Washington, Seattle, Washington 98195, USA. ; Institute of Pharmacy and Molecular Biotechnology and BioQuant, University of Heidelberg, 69117 Heidelberg, Germany. ; Department of Pediatrics, University of Heidelberg, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26814967" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebellar Neoplasms/classification/*genetics/*pathology ; Enhancer Elements, Genetic/*genetics ; Female ; Gene Expression Regulation, Neoplastic/*genetics ; Gene Regulatory Networks/genetics ; Genes, Neoplasm/genetics ; Genes, Reporter/genetics ; Humans ; Male ; Medulloblastoma/*classification/genetics/*pathology ; Mice ; Reproducibility of Results ; Transcription Factors/*metabolism ; Zebrafish/genetics
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, Aled -- England -- Nature. 2016 Mar 17;531(7594):299-301. doi: 10.1038/531299a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Structural Genomics Consortium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26983524" target="_blank"〉PubMed〈/a〉
    Keywords: *Cooperative Behavior ; Drug Industry/economics/manpower/*organization & administration/*standards ; Efficiency, Organizational ; Goals ; Humans ; Information Dissemination ; Reproducibility of Results ; Research/economics/manpower/*organization & administration/*standards
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2016-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allison, David B -- Brown, Andrew W -- George, Brandon J -- Kaiser, Kathryn A -- England -- Nature. 2016 Feb 4;530(7588):27-9. doi: 10.1038/530027a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Alabama, USA. ; Office of Energetics and the Nutrition Obesity Research Center, University of Alabama at Birmingham, Alabama, USA. ; Office of Energetics, University of Alabama at Birmingham, Alabama, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842041" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Editorial Policies ; Humans ; Peer Review, Research/*methods/*standards ; Periodicals as Topic/economics/*standards ; Reproducibility of Results ; Research Design/*statistics & numerical data ; *Retraction of Publication as Topic
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2016-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewandowsky, Stephan -- Bishop, Dorothy -- England -- Nature. 2016 Jan 28;529(7587):459-61. doi: 10.1038/529459a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Bristol, UK, who focuses on the public understanding of science. ; University of Oxford, UK; she chaired a symposium at the Wellcome Trust in London in April 2015 on improving scientific reliability.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26819029" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Censorship, Research ; Confidentiality ; Conflict of Interest ; Dual Use Research/legislation & jurisprudence ; Humans ; *Information Dissemination ; Peer Review, Research ; Reproducibility of Results ; Research/*standards ; Research Personnel/psychology/standards ; Retraction of Publication as Topic ; Social Behavior ; Social Media ; Violence
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2016-03-31
    Description: Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar formation, attenuating scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result in spontaneous regrowth of transected corticospinal, sensory or serotonergic axons through severe spinal cord injury (SCI) lesions. By contrast, sustained local delivery via hydrogel depots of required axon-specific growth factors not present in SCI lesions, plus growth-activating priming injuries, stimulated robust, laminin-dependent sensory axon regrowth past scar-forming astrocytes and inhibitory molecules in SCI lesions. Preventing astrocytic scar formation significantly reduced this stimulated axon regrowth. RNA sequencing revealed that astrocytes and non-astrocyte cells in SCI lesions express multiple axon-growth-supporting molecules. Our findings show that contrary to the prevailing dogma, astrocyte scar formation aids rather than prevents central nervous system axon regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, Mark A -- Burda, Joshua E -- Ren, Yilong -- Ao, Yan -- O'Shea, Timothy M -- Kawaguchi, Riki -- Coppola, Giovanni -- Khakh, Baljit S -- Deming, Timothy J -- Sofroniew, Michael V -- MH099559A/MH/NIMH NIH HHS/ -- MH104069/MH/NIMH NIH HHS/ -- NS057624/NS/NINDS NIH HHS/ -- NS060677/NS/NINDS NIH HHS/ -- NS084030/NS/NINDS NIH HHS/ -- P30 NS062691/NS/NINDS NIH HHS/ -- England -- Nature. 2016 Apr 14;532(7598):195-200. doi: 10.1038/nature17623. Epub 2016 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1763, USA. ; Departments of Psychiatry and Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1761, USA. ; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1751, USA. ; Departments of Bioengineering, Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095-1600, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27027288" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/*pathology ; Axons/*physiology ; Central Nervous System/cytology/*pathology/*physiology ; Chondroitin Sulfate Proteoglycans/biosynthesis ; Cicatrix/*pathology/prevention & control ; Female ; Genomics ; Mice ; *Models, Biological ; *Nerve Regeneration ; Reproducibility of Results ; Spinal Cord Injuries/genetics/pathology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makin, Simon -- England -- Nature. 2016 Mar 3;531(7592):S10-1. doi: 10.1038/531S10a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934518" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Enhancement/*methods ; Brain/*physiology ; Child ; Cognition/physiology ; Controlled Clinical Trials as Topic ; Games, Experimental ; Humans ; Intelligence/physiology ; Memory, Short-Term/*physiology ; Meta-Analysis as Topic ; Reproducibility of Results ; *Uncertainty ; Young Adult
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 11
    Publication Date: 2016-03-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- England -- Nature. 2016 Mar 10;531(7593):151. doi: 10.1038/nature.2016.19503.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26961635" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*methods/*standards ; Models, Biological ; *Probability ; Reproducibility of Results ; *Research Design ; Research Personnel/*education ; Statistics as Topic/*methods/*standards ; Uncertainty
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 12
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bender, Eric -- England -- Nature. 2016 May 11;533(7602):S62-4. doi: 10.1038/533S62a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27167394" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amyotrophic Lateral Sclerosis/diagnosis ; *Awards and Prizes ; Biomedical Research/economics/*manpower/*methods ; Breast Neoplasms/diagnosis/pathology ; *Competitive Behavior ; Cooperative Behavior ; Crowdsourcing/economics/*methods ; Datasets as Topic ; Drug Industry/economics/methods ; Humans ; Information Dissemination ; *Interdisciplinary Communication ; Internet/utilization ; Male ; Models, Biological ; Monitoring, Physiologic/instrumentation ; Prognosis ; Reproducibility of Results ; Smartphone/utilization ; Statistics as Topic ; Systems Biology/manpower/methods ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 13
    Publication Date: 2016-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nardone, Roland M -- MacLeod, Roderick A F -- Capes-Davis, Amanda -- England -- Nature. 2016 Apr 21;532(7599):313.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27127813" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor ; DNA Contamination ; Databases, Factual ; *Disease Models, Animal ; Guidelines as Topic ; Heterografts/*standards ; Humans ; National Cancer Institute (U.S.) ; Neoplasms/*pathology ; Quality Control ; Reproducibility of Results ; United States ; Xenograft Model Antitumor Assays/*standards
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 14
    Publication Date: 2016-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, Angel -- Cheng, Yaping -- Weinfurter, Amy -- Xu, Kaiyang -- Yick, Cameron -- England -- Nature. 2016 Apr 21;532(7599):303-6. doi: 10.1038/532303a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Yale-NUS College and Yale School of Forestry and Environmental Studies, Singapore. ; Yale Data-Driven Environmental Solutions Group, New Haven, Connecticut, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27111615" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Dioxide/analysis ; Cities/*legislation & jurisprudence ; Environmental Pollution/analysis/legislation & jurisprudence/prevention & control ; Global Warming/*legislation & jurisprudence/*prevention & control ; *Government Regulation ; Greenhouse Effect/legislation & jurisprudence/prevention & control ; Industry/*legislation & jurisprudence ; International Cooperation/legislation & jurisprudence ; Private Sector/*legislation & jurisprudence ; Renewable Energy/legislation & jurisprudence ; Reproducibility of Results ; *Research Report/legislation & jurisprudence/standards ; Temperature ; Uncertainty
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 15
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ward, Alyssa -- Baldwin, Thomas O -- Antin, Parker B -- England -- Nature. 2016 Apr 14;532(7598):177. doi: 10.1038/532177d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ; University of California, Riverside, USA. ; University of Arizona, Tucson, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27075087" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Confounding Factors (Epidemiology) ; *Learning ; Mice ; Mice, Transgenic/genetics ; National Institutes of Health (U.S.)/economics ; Reproducibility of Results ; Research/*standards ; United States
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  • 16
    Publication Date: 2016-04-29
    Description: The meaning of language is represented in regions of the cerebral cortex collectively known as the 'semantic system'. However, little of the semantic system has been mapped comprehensively, and the semantic selectivity of most regions is unknown. Here we systematically map semantic selectivity across the cortex using voxel-wise modelling of functional MRI (fMRI) data collected while subjects listened to hours of narrative stories. We show that the semantic system is organized into intricate patterns that seem to be consistent across individuals. We then use a novel generative model to create a detailed semantic atlas. Our results suggest that most areas within the semantic system represent information about specific semantic domains, or groups of related concepts, and our atlas shows which domains are represented in each area. This study demonstrates that data-driven methods--commonplace in studies of human neuroanatomy and functional connectivity--provide a powerful and efficient means for mapping functional representations in the brain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852309/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852309/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huth, Alexander G -- de Heer, Wendy A -- Griffiths, Thomas L -- Theunissen, Frederic E -- Gallant, Jack L -- EY019684/EY/NEI NIH HHS/ -- R01 EY019684/EY/NEI NIH HHS/ -- England -- Nature. 2016 Apr 28;532(7600):453-8. doi: 10.1038/nature17637.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA. ; Department of Psychology, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27121839" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Perception ; *Brain Mapping ; Cerebral Cortex/*anatomy & histology/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Narration ; Principal Component Analysis ; Reproducibility of Results ; *Semantics ; *Speech
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 17
    Publication Date: 2016-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2016 Jan 7;529(7584):9-10. doi: 10.1038/529009a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26738574" target="_blank"〉PubMed〈/a〉
    Keywords: China ; *Federal Government ; Genome, Human/genetics ; Genomics/economics/manpower/trends ; Humans ; Physicians/supply & distribution ; Population Density ; Precision Medicine/economics/*trends ; Reproducibility of Results
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 18
    Publication Date: 2016-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landry, Matt -- Gomes, Aldrin V -- England -- Nature. 2016 Jan 7;529(7584):25. doi: 10.1038/529025c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Aviva Systems Biology, San Diego, California, USA. ; University of California, Davis, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26738583" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies/*immunology ; Biotechnology/*standards ; Blotting, Western/*methods/*standards ; Buffers ; Calibration ; Indicators and Reagents/standards ; Reproducibility of Results
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  • 19
    Publication Date: 2016-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boulton, Geoffrey -- England -- Nature. 2016 Feb 18;530(7590):281. doi: 10.1038/530281c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉ICSU CODATA; and University of Edinburgh, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26887481" target="_blank"〉PubMed〈/a〉
    Keywords: Datasets as Topic ; Information Dissemination/*legislation & jurisprudence ; International Cooperation/*legislation & jurisprudence ; Knowledge ; Open Access Publishing/*legislation & jurisprudence ; Reproducibility of Results ; *Research/legislation & jurisprudence
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  • 20
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bourzac, Katherine -- England -- Nature. 2016 Mar 3;531(7592):S6-8. doi: 10.1038/531S6a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934525" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Biomedical Enhancement/*methods ; Brain/*physiology ; Female ; Humans ; Intelligence Tests ; Male ; Memory/physiology ; Patient Safety ; Reproducibility of Results ; Self Care/adverse effects ; *Transcranial Direct Current Stimulation/adverse effects ; *Transcranial Magnetic Stimulation ; Uncertainty
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  • 21
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buenz, Eric -- England -- Nature. 2016 May 5;533(7601):36. doi: 10.1038/533036d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nelson Marlborough Institute of Technology, Nelson, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27147021" target="_blank"〉PubMed〈/a〉
    Keywords: *Efficiency, Organizational/ethics ; *Goals ; Humans ; Industry/*ethics/organization & administration/*standards ; Reproducibility of Results ; Research/manpower/organization & administration/*standards ; Research Personnel/*ethics/organization & administration/psychology/*standards ; Scientific Misconduct/psychology
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  • 22
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cressey, Daniel -- England -- Nature. 2016 Mar 3;531(7592):128.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26949773" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/*standards ; Animals ; Animals, Laboratory ; Bias (Epidemiology) ; Confidentiality ; Confounding Factors (Epidemiology) ; Feedback ; Guidelines as Topic ; *Internet ; Quality Control ; Random Allocation ; Reproducibility of Results ; *Research Design ; Sample Size ; *Software
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  • 23
    Publication Date: 2016-01-07
    Description: CRISPR-Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide off-target effects of the widely used Streptococcus pyogenes Cas9 (SpCas9) are imperfect, possessing only partial or unproven efficacies and other limitations that constrain their use. Here we describe SpCas9-HF1, a high-fidelity variant harbouring alterations designed to reduce non-specific DNA contacts. SpCas9-HF1 retains on-target activities comparable to wild-type SpCas9 with 〉85% of single-guide RNAs (sgRNAs) tested in human cells. Notably, with sgRNAs targeted to standard non-repetitive sequences, SpCas9-HF1 rendered all or nearly all off-target events undetectable by genome-wide break capture and targeted sequencing methods. Even for atypical, repetitive target sites, the vast majority of off-target mutations induced by wild-type SpCas9 were not detected with SpCas9-HF1. With its exceptional precision, SpCas9-HF1 provides an alternative to wild-type SpCas9 for research and therapeutic applications. More broadly, our results suggest a general strategy for optimizing genome-wide specificities of other CRISPR-RNA-guided nucleases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleinstiver, Benjamin P -- Pattanayak, Vikram -- Prew, Michelle S -- Tsai, Shengdar Q -- Nguyen, Nhu T -- Zheng, Zongli -- Joung, J Keith -- DP1 GM105378/DP/NCCDPHP CDC HHS/ -- R01 GM088040/GM/NIGMS NIH HHS/ -- R01 GM107427/GM/NIGMS NIH HHS/ -- England -- Nature. 2016 Jan 28;529(7587):490-5. doi: 10.1038/nature16526. Epub 2016 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. ; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26735016" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; CRISPR-Associated Proteins/*genetics/*metabolism ; CRISPR-Cas Systems/*physiology ; Clustered Regularly Interspaced Short Palindromic Repeats/*genetics ; DNA/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Endonucleases/genetics/*metabolism ; *Genetic Engineering ; Genome, Human/*genetics ; Humans ; Mutation ; Protein Binding ; RNA/genetics ; Reproducibility of Results ; Sequence Analysis, DNA ; Streptococcus pyogenes/enzymology/genetics ; Substrate Specificity
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  • 24
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2016 Feb 18;530(7590):254. doi: 10.1038/530254a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26887455" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed/*analysis ; *Animal Nutritional Physiological Phenomena ; Animals ; Animals, Laboratory/*physiology ; Diet/*veterinary ; Environment ; Japan ; Longevity/*physiology ; Mice ; Models, Animal ; Reproducibility of Results ; Research Design
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  • 25
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    Nature Publishing Group (NPG)
    Publication Date: 2016-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- England -- Nature. 2016 Jan 28;529(7587):456-8. doi: 10.1038/529456a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26819028" target="_blank"〉PubMed〈/a〉
    Keywords: Accreditation ; Animals ; Calibration ; Financing, Organized/organization & administration ; Laboratories/standards ; Quality Control ; Reproducibility of Results ; Research/*standards ; *Research Design ; Scientific Misconduct
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  • 26
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    Nature Publishing Group (NPG)
    Publication Date: 2016-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gewin, Virginia -- England -- Nature. 2016 Jan 7;529(7584):117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26744755" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Competitive Behavior ; *Information Dissemination ; Journal Impact Factor ; Publishing ; Reproducibility of Results ; *Research/standards ; *Research Personnel/psychology/standards ; Research Support as Topic ; Software
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  • 27
    Publication Date: 2016-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- England -- Nature. 2016 Feb 11;530(7589):141. doi: 10.1038/nature.2016.19269.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26863961" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*standards ; *Biotechnology ; Drug Industry ; *Open Access Publishing ; Reproducibility of Results ; *Uncertainty ; United States
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  • 28
    Publication Date: 2016-01-29
    Description: Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gao, Wei -- Emaminejad, Sam -- Nyein, Hnin Yin Yin -- Challa, Samyuktha -- Chen, Kevin -- Peck, Austin -- Fahad, Hossain M -- Ota, Hiroki -- Shiraki, Hiroshi -- Kiriya, Daisuke -- Lien, Der-Hsien -- Brooks, George A -- Davis, Ronald W -- Javey, Ali -- P01 HG000205/HG/NHGRI NIH HHS/ -- England -- Nature. 2016 Jan 28;529(7587):509-14. doi: 10.1038/nature16521.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA. ; Berkeley Sensor and Actuator Center, University of California, Berkeley, California 94720, USA. ; Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. ; Stanford Genome Technology Center, Stanford School of Medicine, Palo Alto, California 94304, USA. ; Integrative Biology, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26819044" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Bicycling/physiology ; Body Water ; Calibration ; Electrolytes/analysis ; Female ; Glucose/analysis ; Healthy Volunteers ; Humans ; Lactic Acid/analysis ; Male ; Monitoring, Physiologic/*instrumentation/*methods ; Precision Medicine/instrumentation/methods ; Reproducibility of Results ; Running/physiology ; Skin ; Skin Temperature ; Sweat/*chemistry ; Young Adult
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 29
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    Nature Publishing Group (NPG)
    Publication Date: 2015-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoag, Hannah -- England -- Nature. 2015 Nov 19;527(7578):S114-5. doi: 10.1038/527S114a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26580160" target="_blank"〉PubMed〈/a〉
    Keywords: Biomarkers, Tumor/blood/*metabolism ; Breast Neoplasms/*diagnosis/genetics/*metabolism/pathology ; Cell Proliferation ; Disease Progression ; Female ; Genes, Neoplasm/genetics ; Humans ; Medical Overuse/*prevention & control ; Neoplasm Invasiveness/diagnosis/genetics ; Neoplasm Recurrence, Local/diagnosis/genetics ; Prognosis ; Reproducibility of Results ; Tamoxifen/therapeutic use
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  • 30
    Publication Date: 2015-11-13
    Description: The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes in vivo. Here we establish an EMT lineage-tracing system to monitor this process in mice, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models. We show that within a predominantly epithelial primary tumour, a small proportion of tumour cells undergo EMT. Notably, lung metastases mainly consist of non-EMT tumour cells that maintain their epithelial phenotype. Inhibiting EMT by overexpressing the microRNA miR-200 does not affect lung metastasis development. However, EMT cells significantly contribute to recurrent lung metastasis formation after chemotherapy. These cells survived cyclophosphamide treatment owing to reduced proliferation, apoptotic tolerance and increased expression of chemoresistance-related genes. Overexpression of miR-200 abrogated this resistance. This study suggests the potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662610/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662610/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischer, Kari R -- Durrans, Anna -- Lee, Sharrell -- Sheng, Jianting -- Li, Fuhai -- Wong, Stephen T C -- Choi, Hyejin -- El Rayes, Tina -- Ryu, Seongho -- Troeger, Juliane -- Schwabe, Robert F -- Vahdat, Linda T -- Altorki, Nasser K -- Mittal, Vivek -- Gao, Dingcheng -- 1 F31 CA186510-01/CA/NCI NIH HHS/ -- F31 CA186510/CA/NCI NIH HHS/ -- R01 CA135417/CA/NCI NIH HHS/ -- U01 CA188388/CA/NCI NIH HHS/ -- U54 CA149196-05/CA/NCI NIH HHS/ -- England -- Nature. 2015 Nov 26;527(7579):472-6. doi: 10.1038/nature15748. Epub 2015 Nov 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiothoracic Surgery, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA. ; Department of Cell and Developmental Biology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA. ; Neuberger Berman Lung Cancer Center, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA. ; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA. ; Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas 77030, USA. ; Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas, 77030 USA. ; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, 25 Bongjeong-ro Cheonan-Si, Chungcheongnam-do 31151, South Korea. ; Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. ; Institute of Human Nutrition, Columbia University, New York, New York 10032, USA. ; Department of Medicine, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26560033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents, Alkylating/pharmacology/therapeutic use ; Apoptosis/drug effects ; Cell Lineage ; Cell Proliferation/drug effects ; Cell Tracking ; Cyclophosphamide/pharmacology/therapeutic use ; Disease Models, Animal ; Disease Progression ; *Drug Resistance, Neoplasm/drug effects/genetics ; *Epithelial-Mesenchymal Transition/drug effects/genetics ; Female ; Lung Neoplasms/drug therapy/genetics/*pathology/*secondary ; Male ; Mammary Neoplasms, Experimental/*drug therapy/genetics/*pathology ; Mice ; MicroRNAs/genetics ; Neoplasm Metastasis/drug therapy/genetics/*pathology ; Reproducibility of Results
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  • 31
    Publication Date: 2015-09-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Begley, C Glenn -- Buchan, Alastair M -- Dirnagl, Ulrich -- England -- Nature. 2015 Sep 3;525(7567):25-7. doi: 10.1038/525025a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉TetraLogic Pharmaceuticals, Malvern, Pennsylvania, USA. ; Medical Science Division, Oxford NIHR Biomedical Research Centre, University of Oxford, UK. ; Center for Stroke Research at the Universitatsmedizin Charite Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26333454" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bias (Epidemiology) ; Humans ; Peer Review, Research/*methods/*standards ; Reproducibility of Results ; Research/*standards/statistics & numerical data ; Research Design/*standards ; Scientific Misconduct/statistics & numerical data
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  • 32
    Publication Date: 2015-11-13
    Description: Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is derived from the developing sympathetic nervous system. Clinical phenotypes range from localized tumours with excellent outcomes to widely metastatic disease in which long-term survival is approximately 40% despite intensive therapy. A previous genome-wide association study identified common polymorphisms at the LMO1 gene locus that are highly associated with neuroblastoma susceptibility and oncogenic addiction to LMO1 in the tumour cells. Here we investigate the causal DNA variant at this locus and the mechanism by which it leads to neuroblastoma tumorigenesis. We first imputed all possible genotypes across the LMO1 locus and then mapped highly associated single nucleotide polymorphism (SNPs) to areas of chromatin accessibility, evolutionary conservation and transcription factor binding sites. We show that SNP rs2168101 G〉T is the most highly associated variant (combined P = 7.47 x 10(-29), odds ratio 0.65, 95% confidence interval 0.60-0.70), and resides in a super-enhancer defined by extensive acetylation of histone H3 lysine 27 within the first intron of LMO1. The ancestral G allele that is associated with tumour formation resides in a conserved GATA transcription factor binding motif. We show that the newly evolved protective TATA allele is associated with decreased total LMO1 expression (P = 0.028) in neuroblastoma primary tumours, and ablates GATA3 binding (P 〈 0.0001). We demonstrate allelic imbalance favouring the G-containing strand in tumours heterozygous for this SNP, as demonstrated both by RNA sequencing (P 〈 0.0001) and reporter assays (P = 0.002). These findings indicate that a recently evolved polymorphism within a super-enhancer element in the first intron of LMO1 influences neuroblastoma susceptibility through differential GATA transcription factor binding and direct modulation of LMO1 expression in cis, and this leads to an oncogenic dependency in tumour cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775078/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775078/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oldridge, Derek A -- Wood, Andrew C -- Weichert-Leahey, Nina -- Crimmins, Ian -- Sussman, Robyn -- Winter, Cynthia -- McDaniel, Lee D -- Diamond, Maura -- Hart, Lori S -- Zhu, Shizhen -- Durbin, Adam D -- Abraham, Brian J -- Anders, Lars -- Tian, Lifeng -- Zhang, Shile -- Wei, Jun S -- Khan, Javed -- Bramlett, Kelli -- Rahman, Nazneen -- Capasso, Mario -- Iolascon, Achille -- Gerhard, Daniela S -- Guidry Auvil, Jaime M -- Young, Richard A -- Hakonarson, Hakon -- Diskin, Sharon J -- Look, A Thomas -- Maris, John M -- 100210/Wellcome Trust/United Kingdom -- 100210/Z/12/Z/Wellcome Trust/United Kingdom -- 1K99CA178189/CA/NCI NIH HHS/ -- R00-CA151869/CA/NCI NIH HHS/ -- R01 CA124709/CA/NCI NIH HHS/ -- R01 CA180692/CA/NCI NIH HHS/ -- R01-CA109901/CA/NCI NIH HHS/ -- R01-CA124709/CA/NCI NIH HHS/ -- R01-CA180692/CA/NCI NIH HHS/ -- RC1MD004418/MD/NIMHD NIH HHS/ -- T32 HG000046/HG/NHGRI NIH HHS/ -- T32-HG000046/HG/NHGRI NIH HHS/ -- England -- Nature. 2015 Dec 17;528(7582):418-21. doi: 10.1038/nature15540. Epub 2015 Nov 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. ; Medical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, Auckland Region 1142, New Zealand. ; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA. ; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02115, USA. ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA. ; Whitehead Institute for Biomedical Research and MIT, Boston, Massachusetts 02142, USA. ; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. ; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. ; Thermo Fisher Scientific, Austin, Texas 78744, USA. ; The Institute of Cancer Research, London SM2 5NG, UK. ; University of Naples Federico II, 80131 Naples, Italy. ; CEINGE Biotecnologie Avanzate, 80131 Naples, Italy. ; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA. ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ; Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26560027" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Alleles ; Allelic Imbalance ; Binding Sites ; DNA-Binding Proteins/*genetics ; Enhancer Elements, Genetic/*genetics ; Epigenomics ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Genotype ; Histones/chemistry/metabolism ; Humans ; Introns/genetics ; LIM Domain Proteins/*genetics ; Lysine/metabolism ; Neuroblastoma/*genetics ; Organ Specificity ; Polymorphism, Single Nucleotide/*genetics ; Reproducibility of Results ; Transcription Factors/*genetics
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  • 33
    Publication Date: 2015-09-04
    Description: The global extent and distribution of forest trees is central to our understanding of the terrestrial biosphere. We provide the first spatially continuous map of forest tree density at a global scale. This map reveals that the global number of trees is approximately 3.04 trillion, an order of magnitude higher than the previous estimate. Of these trees, approximately 1.39 trillion exist in tropical and subtropical forests, with 0.74 trillion in boreal regions and 0.61 trillion in temperate regions. Biome-level trends in tree density demonstrate the importance of climate and topography in controlling local tree densities at finer scales, as well as the overwhelming effect of humans across most of the world. Based on our projected tree densities, we estimate that over 15 billion trees are cut down each year, and the global number of trees has fallen by approximately 46% since the start of human civilization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crowther, T W -- Glick, H B -- Covey, K R -- Bettigole, C -- Maynard, D S -- Thomas, S M -- Smith, J R -- Hintler, G -- Duguid, M C -- Amatulli, G -- Tuanmu, M-N -- Jetz, W -- Salas, C -- Stam, C -- Piotto, D -- Tavani, R -- Green, S -- Bruce, G -- Williams, S J -- Wiser, S K -- Huber, M O -- Hengeveld, G M -- Nabuurs, G-J -- Tikhonova, E -- Borchardt, P -- Li, C-F -- Powrie, L W -- Fischer, M -- Hemp, A -- Homeier, J -- Cho, P -- Vibrans, A C -- Umunay, P M -- Piao, S L -- Rowe, C W -- Ashton, M S -- Crane, P R -- Bradford, M A -- England -- Nature. 2015 Sep 10;525(7568):201-5. doi: 10.1038/nature14967. Epub 2015 Sep 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Yale School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA. ; Department of Environmental Sciences, University of Helsinki, Helsinki 00014, Finland. ; Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA. ; Department of Life Sciences, Silwood Park, Imperial College, London SL5 7PY, UK. ; Departamento de Ciencias Forestales, Universidad de La Frontera, Temuco 4811230, Chile. ; RedCastle Resources, Salt Lake City, Utah 84103, USA. ; Universidade Federal do Sul da Bahia, Ferradas, Itabuna 45613-204, Brazil. ; Forestry Department, Food and Agriculture Organization of the United Nations, Rome 00153, Italy. ; Operation Wallacea, Spilbsy, Lincolnshire PE23 4EX, UK. ; Durrell Institute of Conservation and Ecology (DICE), School of Anthropology and Conservation (SAC), University of Kent, Canterbury ME4 4AG, UK. ; Molecular Imaging Research Center MIRCen/CEA, CNRS URA 2210, 91401 Orsay Cedex, France. ; Landcare Research, Lincoln 7640, New Zealand. ; WSL, Swiss Federal Institute for Forest, Snow and Landscape Research, 8903 Birmensdorf, Switzerland. ; Environmental Science Group, Wageningen University &Research Centre, 6708 PB, The Netherlands. ; Center for Forest Ecology and Productivity RAS, Moscow 117997, Russia. ; CEN Center for Earth System Research and Sustainability, Institute of Geography, University of Hamburg, Hamburg 20146, Germany. ; Department of Botany and Zoology, Masaryk University, Brno 61137, Czech Republic. ; South African National Biodiversity Institute, Kirstenbosch Research Centre, Claremont 7735, South Africa. ; Institute of Plant Sciences, Botanical Garden, and Oeschger Centre for Climate Change Research, University of Bern, 3013 Bern, Switzerland. ; Senckenberg Gesellschaft fur Naturforschung, Biodiversity and Climate Research Centre (BIK-F), 60325 Frankfurt, Germany. ; Department of Plant Systematics, University of Bayreuth, 95447 Bayreuth, Germany. ; Albrecht von Haller Institute of Plant Sciences, Georg August University of Gottingen, 37073 Gottingen, Germany. ; Tropical Ecology Research Group, Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK. ; Universidade Regional de Blumenau, Departamento de Engenharia Florestal, Blumenau/Santa Catarina 89030-000, Brazil. ; Sino-French Institute for Earth System Science, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26331545" target="_blank"〉PubMed〈/a〉
    Keywords: Ecology/statistics & numerical data ; Ecosystem ; Forestry/statistics & numerical data ; *Forests ; *Geographic Mapping ; Population Density ; Reproducibility of Results ; Trees/*growth & development
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  • 34
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2015-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gewin, Virginia -- England -- Nature. 2015 Jan 8;517(7533):231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25574536" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Communication ; Fisheries ; Humans ; Policy Making ; Public Opinion ; Reproducibility of Results ; *Research Personnel/psychology/standards ; Science/*education
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  • 35
    Publication Date: 2015-11-10
    Description: Gene expression is regulated by transcription factors (TFs), proteins that recognize short DNA sequence motifs. Such sequences are very common in the human genome, and an important determinant of the specificity of gene expression is the cooperative binding of multiple TFs to closely located motifs. However, interactions between DNA-bound TFs have not been systematically characterized. To identify TF pairs that bind cooperatively to DNA, and to characterize their spacing and orientation preferences, we have performed consecutive affinity-purification systematic evolution of ligands by exponential enrichment (CAP-SELEX) analysis of 9,400 TF-TF-DNA interactions. This analysis revealed 315 TF-TF interactions recognizing 618 heterodimeric motifs, most of which have not been previously described. The observed cooperativity occurred promiscuously between TFs from diverse structural families. Structural analysis of the TF pairs, including a novel crystal structure of MEIS1 and DLX3 bound to their identified recognition site, revealed that the interactions between the TFs were predominantly mediated by DNA. Most TF pair sites identified involved a large overlap between individual TF recognition motifs, and resulted in recognition of composite sites that were markedly different from the individual TF's motifs. Together, our results indicate that the DNA molecule commonly plays an active role in cooperative interactions that define the gene regulatory lexicon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jolma, Arttu -- Yin, Yimeng -- Nitta, Kazuhiro R -- Dave, Kashyap -- Popov, Alexander -- Taipale, Minna -- Enge, Martin -- Kivioja, Teemu -- Morgunova, Ekaterina -- Taipale, Jussi -- England -- Nature. 2015 Nov 19;527(7578):384-8. doi: 10.1038/nature15518. Epub 2015 Nov 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83, Sweden. ; European Synchrotron Radiation Facility, 38043 Grenoble, France. ; Genome-Scale Biology Program, University of Helsinki, P.O. Box 63, FI-00014, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26550823" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Binding Sites/genetics ; Crystallography, X-Ray ; DNA/*genetics/*metabolism ; Gene Expression Regulation/genetics ; Humans ; Molecular Sequence Data ; Nucleotide Motifs/genetics ; Reproducibility of Results ; *Substrate Specificity/genetics ; Transcription Factors/*metabolism
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  • 36
    Publication Date: 2015-06-13
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636083/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636083/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lloyd, Kent -- Franklin, Craig -- Lutz, Cat -- Magnuson, Terry -- U24 DK092993/DK/NIDDK NIH HHS/ -- U42 OD010921/OD/NIH HHS/ -- U42 OD011175/OD/NIH HHS/ -- U42 OD012210/OD/NIH HHS/ -- U42 RR033193/RR/NCRR NIH HHS/ -- U54 HG006364/HG/NHGRI NIH HHS/ -- England -- Nature. 2015 Jun 11;522(7555):151-3. doi: 10.1038/522151a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mutant Mouse Resource and Research Center (MMRRC) at the University of California, Davis, California, USA. ; MMRRC at the University of Missouri, Columbia, Missouri, USA. ; MMRRC at the Jackson Laboratory in Bar Harbor, Maine, USA. ; MMRRC at the University of North Carolina at Chapel Hill, North Carolina, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26062496" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Specimen Banks/*standards/*utilization ; DNA Mutational Analysis ; Disease Models, Animal ; Genetic Testing ; Genome/genetics ; Humans ; *Mice/classification/genetics/microbiology ; Mice, Inbred C57BL ; Microbiota/genetics ; Mutation/genetics ; Quality Control ; Reproducibility of Results
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 37
    Publication Date: 2015-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradbury, Andrew -- Pluckthun, Andreas -- England -- Nature. 2015 Feb 5;518(7537):27-9. doi: 10.1038/518027a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA. ; Biochemistry Department of the University of Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25652980" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antibodies/*chemistry/economics/*immunology/isolation & purification ; Antibodies, Monoclonal/biosynthesis/chemistry/immunology/isolation & purification ; *Antibody Specificity ; Biomedical Research/*standards ; Hybridomas/cytology/immunology/metabolism ; Immune Sera/immunology ; Indicators and Reagents/economics ; Quality Control ; Recombinant Proteins/*biosynthesis/economics/immunology/*isolation & purification ; Reproducibility of Results
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  • 38
    Publication Date: 2015-01-17
    Description: The structure of water near non-polar molecular fragments or surfaces mediates the hydrophobic interactions that underlie a broad range of interfacial, colloidal and biophysical phenomena. Substantial progress over the past decade has improved our understanding of hydrophobic interactions in simple model systems, but most biologically and technologically relevant structures contain non-polar domains in close proximity to polar and charged functional groups. Theories and simulations exploring such nanometre-scale chemical heterogeneity find it can have an important effect, but the influence of this heterogeneity on hydrophobic interactions has not been tested experimentally. Here we report chemical force microscopy measurements on alkyl-functionalized surfaces that reveal a dramatic change in the surfaces' hydrophobic interaction strengths on co-immobilization of amine or guanidine groups. Protonation of amine groups doubles the strength of hydrophobic interactions, and guanidinium groups eliminate measurable hydrophobic interactions in all pH ranges investigated. We see these divergent effects of proximally immobilized cations also in single-molecule measurements on conformationally stable beta-peptides with non-polar subunits located one nanometre from either amine- or guanidine-bearing subunits. Our results demonstrate the importance of nanometre-scale chemical heterogeneity, with hydrophobicity not an intrinsic property of any given non-polar domain but strongly modulated by functional groups located as far away as one nanometre. The judicious placing of charged groups near hydrophobic domains thus provides a strategy for tuning hydrophobic driving forces to optimize molecular recognition or self-assembly processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ma, C Derek -- Wang, Chenxuan -- Acevedo-Velez, Claribel -- Gellman, Samuel H -- Abbott, Nicholas L -- England -- Nature. 2015 Jan 15;517(7534):347-50. doi: 10.1038/nature14018.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA. ; 1] Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA [2] Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA. ; Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25592540" target="_blank"〉PubMed〈/a〉
    Keywords: Ammonium Compounds/chemistry ; Arginine/chemistry ; Buffers ; Cations/chemistry ; Colloids/chemistry ; Ethanolamines/chemistry ; Guanidine/chemistry ; Hydrogen-Ion Concentration ; *Hydrophobic and Hydrophilic Interactions ; Lysine/chemistry ; Methanol/chemistry ; Microscopy, Atomic Force ; Peptides/chemistry ; Protons ; Reproducibility of Results ; Surface Properties
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  • 39
    Publication Date: 2015-12-18
    Description: The response of the Greenland Ice Sheet (GIS) to changes in temperature during the twentieth century remains contentious, largely owing to difficulties in estimating the spatial and temporal distribution of ice mass changes before 1992, when Greenland-wide observations first became available. The only previous estimates of change during the twentieth century are based on empirical modelling and energy balance modelling. Consequently, no observation-based estimates of the contribution from the GIS to the global-mean sea level budget before 1990 are included in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. Here we calculate spatial ice mass loss around the entire GIS from 1900 to the present using aerial imagery from the 1980s. This allows accurate high-resolution mapping of geomorphic features related to the maximum extent of the GIS during the Little Ice Age at the end of the nineteenth century. We estimate the total ice mass loss and its spatial distribution for three periods: 1900-1983 (75.1 +/- 29.4 gigatonnes per year), 1983-2003 (73.8 +/- 40.5 gigatonnes per year), and 2003-2010 (186.4 +/- 18.9 gigatonnes per year). Furthermore, using two surface mass balance models we partition the mass balance into a term for surface mass balance (that is, total precipitation minus total sublimation minus runoff) and a dynamic term. We find that many areas currently undergoing change are identical to those that experienced considerable thinning throughout the twentieth century. We also reveal that the surface mass balance term shows a considerable decrease since 2003, whereas the dynamic term is constant over the past 110 years. Overall, our observation-based findings show that during the twentieth century the GIS contributed at least 25.0 +/- 9.4 millimetres of global-mean sea level rise. Our result will help to close the twentieth-century sea level budget, which remains crucial for evaluating the reliability of models used to predict global sea level rise.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kjeldsen, Kristian K -- Korsgaard, Niels J -- Bjork, Anders A -- Khan, Shfaqat A -- Box, Jason E -- Funder, Svend -- Larsen, Nicolaj K -- Bamber, Jonathan L -- Colgan, William -- van den Broeke, Michiel -- Siggaard-Andersen, Marie-Louise -- Nuth, Christopher -- Schomacker, Anders -- Andresen, Camilla S -- Willerslev, Eske -- Kjaer, Kurt H -- England -- Nature. 2015 Dec 17;528(7582):396-400. doi: 10.1038/nature16183.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for GeoGenetics, Natural History Museum, University of Copenhagen, Copenhagen 1350, Denmark. ; Department of Earth Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. ; DTU Space-National Space Institute, Technical University of Denmark, Department of Geodesy, Kongens Lyngby 2800, Denmark. ; Geological Survey of Denmark and Greenland, Department of Marine Geology and Glaciology, Copenhagen 1350, Denmark. ; Department of Geoscience, Aarhus University, Aarhus 8000, Denmark. ; Bristol Glaciology Centre, University of Bristol, Bristol BS8 1SS, UK. ; Department of Earth and Space Science and Engineering, York University, Toronto, Ontario M3J 1P3, Canada. ; Institute for Marine and Atmospheric Research, Utrecht University, Utrecht 80005, The Netherlands. ; Department of Geosciences, University of Oslo, Oslo 0316, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26672555" target="_blank"〉PubMed〈/a〉
    Keywords: Climate Change/*statistics & numerical data ; Greenland ; History, 20th Century ; History, 21st Century ; *Ice Cover ; Models, Theoretical ; Observation ; Photography ; Reproducibility of Results ; Seawater/analysis ; *Spatio-Temporal Analysis ; Temperature
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  • 40
    Publication Date: 2015-02-20
    Description: Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage specification remains to be determined. By mapping genome-wide chromatin interactions in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover extensive chromatin reorganization during lineage specification. We observe that although self-associating chromatin domains are stable during differentiation, chromatin interactions both within and between domains change in a striking manner, altering 36% of active and inactive chromosomal compartments throughout the genome. By integrating chromatin interaction maps with haplotype-resolved epigenome and transcriptome data sets, we find widespread allelic bias in gene expression correlated with allele-biased chromatin states of linked promoters and distal enhancers. Our results therefore provide a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515363/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515363/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dixon, Jesse R -- Jung, Inkyung -- Selvaraj, Siddarth -- Shen, Yin -- Antosiewicz-Bourget, Jessica E -- Lee, Ah Young -- Ye, Zhen -- Kim, Audrey -- Rajagopal, Nisha -- Xie, Wei -- Diao, Yarui -- Liang, Jing -- Zhao, Huimin -- Lobanenkov, Victor V -- Ecker, Joseph R -- Thomson, James A -- Ren, Bing -- R01 ES024984/ES/NIEHS NIH HHS/ -- T32 GM007198/GM/NIGMS NIH HHS/ -- U01 ES017166/ES/NIEHS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Feb 19;518(7539):331-6. doi: 10.1038/nature14222.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, California 92093-0653, USA [2] Medical Scientist Training Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. ; Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, California 92093-0653, USA. ; 1] Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, California 92093-0653, USA [2] Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. ; The Morgridge Institute for Research, 309 North Orchard Street, Madison, Wisconsin 53715, USA. ; Tsinghua University-Peking University Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. ; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. ; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook I NIAID Facility, Room 1417, 5640 Fishers Lane, Rockville, Maryland 20852, USA. ; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA. ; 1] The Morgridge Institute for Research, 309 North Orchard Street, Madison, Wisconsin 53715, USA [2] Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA [3] Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, California 93106, USA. ; 1] Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, California 92093-0653, USA [2] University of California, San Diego School of Medicine, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25693564" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Allelic Imbalance/genetics ; *Cell Differentiation/genetics ; Cell Lineage/genetics ; Chromatin/*chemistry/genetics/*metabolism ; *Chromatin Assembly and Disassembly/genetics ; Embryonic Stem Cells/*cytology/*metabolism ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Gene Regulatory Networks ; Humans ; Promoter Regions, Genetic/genetics ; Reproducibility of Results
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  • 41
    facet.materialart.
    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2015-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2015 Jan 29;517(7536):537-8. doi: 10.1038/517537a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25631423" target="_blank"〉PubMed〈/a〉
    Keywords: *Decision Making/physiology ; Humans ; Psychology/standards ; Reproducibility of Results ; *Unconscious (Psychology)
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  • 42
    Publication Date: 2015-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sims, David W -- Simpson, Samantha J -- England -- Nature. 2015 Apr 30;520(7549):623. doi: 10.1038/520623e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marine Biological Association of the United Kingdom, Plymouth, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25925469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources/*legislation & jurisprudence/*statistics & ; numerical data ; Endangered Species/legislation & jurisprudence/statistics & numerical data ; European Union ; Fisheries/*legislation & jurisprudence/*statistics & numerical data ; *Fishes ; Reproducibility of Results ; Skates (Fish) ; Uncertainty
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  • 43
    Publication Date: 2015-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, Warwick P -- England -- Nature. 2015 Mar 12;519(7542):158. doi: 10.1038/519158a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Health and Medical Research Council of Australia, Canberra, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25762270" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics/*methods/*standards ; Humans ; International Cooperation ; Reproducibility of Results ; Scientific Misconduct
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  • 44
    Publication Date: 2015-12-04
    Description: Mass-screen-and-treat and targeted mass-drug-administration strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future diagnostics are able to detect those individuals who are infectious to mosquitoes. We estimate the relationship between parasite density and onward infectivity using sensitive quantitative parasite diagnostics and mosquito feeding assays from Burkina Faso. We find that a diagnostic with a lower detection limit of 200 parasites per microlitre would detect 55% of the infectious reservoir (the combined infectivity to mosquitoes of the whole population weighted by how often each individual is bitten) whereas a test with a limit of 20 parasites per microlitre would detect 83% and 2 parasites per microlitre would detect 95% of the infectious reservoir. Using mathematical models, we show that increasing the diagnostic sensitivity from 200 parasites per microlitre (equivalent to microscopy or current rapid diagnostic tests) to 2 parasites per microlitre would increase the number of regions where transmission could be interrupted with a mass-screen-and-treat programme from an entomological inoculation rate below 1 to one of up to 4. The higher sensitivity diagnostic could reduce the number of treatment rounds required to interrupt transmission in areas of lower prevalence. We predict that mass-screen-and-treat with a highly sensitive diagnostic is less effective than mass drug administration owing to the prophylactic protection provided to uninfected individuals by the latter approach. In low-transmission settings such as those in Southeast Asia, we find that a diagnostic tool with a sensitivity of 20 parasites per microlitre may be sufficient for targeted mass drug administration because this diagnostic is predicted to identify a similar village population prevalence compared with that currently detected using polymerase chain reaction if treatment levels are high and screening is conducted during the dry season. Along with other factors, such as coverage, choice of drug, timing of the intervention, importation of infections, and seasonality, the sensitivity of the diagnostic can play a part in increasing the chance of interrupting transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slater, Hannah C -- Ross, Amanda -- Ouedraogo, Andre Lin -- White, Lisa J -- Nguon, Chea -- Walker, Patrick G T -- Ngor, Pengby -- Aguas, Ricardo -- Silal, Sheetal P -- Dondorp, Arjen M -- La Barre, Paul -- Burton, Robert -- Sauerwein, Robert W -- Drakeley, Chris -- Smith, Thomas A -- Bousema, Teun -- Ghani, Azra C -- 106698/Z/14/Z/Wellcome Trust/United Kingdom -- England -- Nature. 2015 Dec 3;528(7580):S94-101. doi: 10.1038/nature16040.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK. ; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland. ; University of Basel, Petersplatz 1, 4001 Basel, Switzerland. ; Institute for Disease Modelling, Bellevue, Washington 98005, USA. ; Department of Biomedical Sciences, Centre National de Recherche et de Formation sur le Paludisme, 01 B.P. 2208, Ouagadougou, Burkina Faso. ; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. ; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK. ; National Malaria Center, Ministry of Health, Phnom Penh 12302, Cambodia. ; Department of Statistical Sciences, University of Cape Town, Rondebosch 7701, Cape Town, South Africa. ; PATH, 2201 Westlake Avenue, Seattle, Washington 98121, USA. ; Radboud University Medical Center, 6525 HP Nijmegen, the Netherlands. ; London School of Hygiene &Tropical Medicine, Keppel St, London WC1E 7HT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26633771" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; *Diagnostic Tests, Routine ; Female ; Humans ; Malaria, Falciparum/*diagnosis/*drug therapy/epidemiology/parasitology ; Male ; Plasmodium falciparum/*drug effects/*isolation & purification ; Polymerase Chain Reaction ; Prevalence ; Reproducibility of Results ; Young Adult
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 45
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    Nature Publishing Group (NPG)
    Publication Date: 2015-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2015 Dec 17;528(7582):S120-2. doi: 10.1038/528S120a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26672781" target="_blank"〉PubMed〈/a〉
    Keywords: Early Diagnosis ; False Positive Reactions ; Humans ; Male ; Mass Screening/trends ; Prognosis ; Prostate-Specific Antigen/*blood ; Prostatic Neoplasms/*blood/*diagnosis/psychology ; Reproducibility of Results ; Risk Assessment ; Stress, Psychological/etiology/prevention & control
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
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