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  • 1
    Keywords: Life sciences ; Biotechnology ; Organic Chemistry ; Biochemistry ; Cell Biology ; Life sciences ; Cell Biology ; Biochemistry, general ; Biotechnology ; Organic Chemistry ; Springer eBooks
    Description / Table of Contents: 1. Trends in bioprobe research -- 2. Cell proliferation and differentiation -- 3. Epigenetics -- 4. Apoptosis and autophagy -- 5. Adaptive and innate immune Systems -- 6. Bioprobes at a glance
    Abstract: This new edition provides the most advanced research using bioprobes on the chemical control of 1) cell cycle and differentiation, 2) epigenetics, 3) apoptosis and autophagy, and 4) immune response. The “bioprobe”, first proposed in the first edition, has become an indispensable tool for chemical biology and has substantially assisted in the investigation of complex biochemical processes of cells. New areas of investigation such as stem cell research, epigenetic research, and autophagy research have rapidly advanced in the past 10 years. Including these new findings, this second edition supplies up-to-date information on the biochemical tools called bioprobes. Data on each bioprobe, such as chemical structure, origin, function, and references, are presented as one item in this volume. Readers will easily find useful information and will be able to determine the appropriate bioprobes to investigate cell functions. The information on bioprobes and their use in research makes this book a valuable source for researchers in diverse fields. Not only scientists in academia but also in the pharmaceutical industries will discover the most important information about small molecules useful for drug discovery
    Pages: VIII, 384 p. 173 illus., 10 illus. in color. : online resource.
    Edition: 2nd ed. 2017.
    ISBN: 9784431565291
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  • 2
    Keywords: Medicine ; Neurochemistry ; Organic Chemistry ; Radiology ; Biomedicine ; Neurochemistry ; Organic Chemistry ; Imaging / Radiology ; Springer eBooks
    Abstract: This book explores the revolutionary fMRI field from basic principles to state-of-the-art research. It covers a broad spectrum of topics, including the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, quantitative fMRI, genetic imaging using fMRI, multimodal neuroimaging, brain bioenergetics and function, and molecular-level fMRI. Comprehensive and intuitively structured, this book examines the physiological basis of fMRI, the basic principles of fMRI and its applications, and the latest advances of the technology. The final chapter discusses the field's future. fMRI: From Nuclear Spins to Brain Function is an ideal resource for clinicians and researchers in the fields of neuroscience, psychology, and MRI physics. This book also: ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Explores a wide range of topics, covering the physical basics, physiological bases, a selection of various applications, and cutting-edge advances in fMRI ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Engages the reader with a first-person account of the development and history of the fMRI field by the authors ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Discusses fMRI applications in a variety of contexts, including fMRI of the visual system, auditory cortex, and sensorimotor system as well as the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, and℗ quantitative fMRI ℗
    Pages: XVIII, 929 p. 235 illus., 179 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9781489975911
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  • 3
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Medicine ; Chemistry, Organic ; Biochemistry ; Life sciences ; Protein Science ; Biomedicine general ; Organic Chemistry ; Springer eBooks
    Description / Table of Contents: Sequences -- Structures -- Systems
    Abstract: This book describes more than 60 web-accessible computational tools for protein analysis and is totally practical, with detailed explanations on how to use these tools and interpret their results and minimal mentions to their theoretical basis (only when that is required for making a better use of them). It covers a wide range of tools for dealing with different aspects of proteins, from their sequences, to their three-dimensional structures, and the biological networks they are immersed in. The selection of tools is based on the experience of the authors that lead a protein bioinformatics facility in a large research centre, with the additional constraint that the tools should be accessible through standard web browsers without requiring the local installation of specific software, command-line tools, etc. The web tools covered include those aimed to retrieve protein information, look for similar proteins, generate pair-wise and multiple sequence alignments of protein sequences, work with protein domains and motifs, study the phylogeny of a family of proteins, retrieve, manipulate and visualize protein three-dimensional structures, predict protein structural features as well as whole three-dimensional structures, extract biological information from protein structures, summarize large protein sets, study protein interaction and metabolic networks, etc. The book is associated to a dynamic web site that will reflect changes in the web addresses of the tools, updates of these, etc. It also contains QR codes that can be scanned with any device to direct its browser to the tool web site. This monograph will be most valuable for researchers in experimental labs without specific knowledge on bioinformatics or computing
    Pages: VIII, 106 p. 40 illus. in color. : online resource.
    ISBN: 9783319127279
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  • 4
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    Cham : Springer International Publishing
    Keywords: Medicine ; Chemistry, Organic ; Life sciences ; Biomedicine ; Biomedicine general ; Life Sciences, general ; Organic Chemistry ; Springer eBooks
    Description / Table of Contents: Alkanes, Composition, Constitution and Configuration -- Functional Groups -- Electronic Structure of Organic Molecules -- Alkenes and Alkynes -- Substitutions on Saturated Carbon Atom -- Nucleophilic Additions -- Stereochemistry, Symmetry and Molecular Chirality -- Derivatives of Carboxylic Acids -- Electrophilic Substitutions -- Cycloadditions -- Organic Natural Products
    Abstract: This work provides an overview of the basics of organic chemistry for non-chemists. As such, this book should be very useful for university students of biology, molecular biology, ecology, medicine, agriculture, forestry, and other specialties where the knowledge of organic chemistry plays the important role but is not a core discipline. The book should also be of interest to non-professionals, and it may serve as a manual or repetitorium to high school teachers. ℗ The text is divided into eleven chapters on the basis of the systematization of fundamental organic reaction types, and classes of organic compounds. The first chapters comprise fundamental aspects of structural theory, reaction mechanisms, electronic structure, some basic spectroscopy, and properties of main groups of organic compounds. At the end of the book, the largest chapter contains the elements of the organic chemistry of natural products. Comparison of the reactions in the laboratory with the analogous molecular transformations in living cells will enable the reader to better understand the basic principles of biochemistry
    Pages: XIII, 179 p. 331 illus., 51 illus. in color. : online resource.
    ISBN: 9783319076058
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  • 5
    Keywords: Medicine ; Spectroscopy ; Biotechnology ; Chemistry, Organic ; Chemistry, Physical organic ; Biochemistry ; Biomedicine ; Biomedicine general ; Spectroscopy/Spectrometry ; Biotechnology ; Physical Chemistry ; Organic Chemistry ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: The basis of Nuclear Magnetic Resonance Spectroscopy -- Spectroscopic parameters in Nuclear Magnetic Resonance -- Basic NMR experiments -- Biomolecular NMR
    Abstract: This book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can be ascribed to the development experienced by NMR in recent times. Many of the books currently available on NMR deal with the theoretical basis and some of its main applications, but they generally demand a strong background in Physics and Mathematics for a full understanding. This book is aimed to a wide scientific audience, trying to introduce NMR by making all possible effort to remove, without losing any formality and rigor, most of the theoretical jargon that is present in other NMR books. Furthermore, illustrations are provided that show all the basic concepts using a naive vector formalism, or using a simplified approach to the particular NMR-technique described. The intention has been to show simply the foundations and main concepts of NMR, rather than seeking thorough mathematical expressions
    Pages: XII, 115 p. 36 ill. : digital.
    ISBN: 9789400769762
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  • 6
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    Dordrecht : Springer
    Keywords: Medicine ; Spectroscopy ; Chemistry, Organic ; Chemistry, Physical organic ; Chemistry ; Biomedicine ; Biomedicine general ; Organic Chemistry ; Physical Chemistry ; Spectroscopy/Spectrometry ; Organometallic chemistry ; Electrochemistry ; Springer eBooks
    Description / Table of Contents: Molecular structures -- An overview of synthetic methods for preparation of nitrosoaromatic compounds -- Molecular properties and spectroscopy -- Organometallic compounds -- Bilological systems
    Abstract: This volume will present the reader with an update on the scientific research on organic chemistry of nitroso compounds that was performed in the last two decades. The overview will include the original synthetic applications of nitroso compounds, but will also cover the discovery of novel physico-chemical phenomena and their potential future uses. The properties that form the basis for this technological potential originate from the intriguing property of C-nitroso molecules to form dimers through the formation of a relatively weak nitrogen-nitrogen double bond. The equilibrium between the different monomeric and dimeric forms, which appears under controlled environmental parameters, opened new areas of research in organic chemistry.The novel paradigm presented in this volume includes insight into the original problem of organic reactivity and synthesis, but also sheds light on the solid-state reaction mechanisms. A number of fascinating photochemical, electrochemical, supramolecular, and biological properties, as well as advanced techniques in spectroscopy, now enables us to use these compounds as molecular models for studying a number of general chemical concepts.℗
    Pages: : digital.
    ISBN: 9789400763371
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  • 7
    Keywords: Life sciences ; Toxicology ; Chemistry, Organic ; Pharmacy ; Oceanography ; Biochemistry ; Aquatic biology ; Life sciences ; Biochemistry, general ; Organic Chemistry ; Freshwater & Marine Ecology ; Oceanography ; Pharmacology/Toxicology ; Pharmacy ; Springer eBooks
    ISBN: 9789048138340
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  • 8
    Keywords: Life sciences ; Chemistry, Organic ; Carbohydrates ; Biochemistry ; Proteomics ; Cytology ; Cell Membranes ; Life sciences ; Biochemistry, general ; Organic Chemistry ; Carbohydrate Chemistry ; Cell Biology ; Membrane Biology ; Proteomics ; Springer eBooks
    Pages: : digital.
    ISBN: 9781461433811
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  • 9
    Keywords: Chemistry ; Chemistry, Organic ; Chemistry ; Organic Chemistry ; Springer eBooks
    Pages: : digital
    ISBN: 9781441972705
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  • 10
    Keywords: Medicine ; Toxicology ; Pharmaceutical technology ; Chemistry, Organic ; Chemical engineering ; Biochemistry ; Biomedicine ; Pharmacology/Toxicology ; Pharmaceutical Sciences/Technology ; Organic Chemistry ; Medicinal Chemistry ; Medical Biochemistry ; Industrial Chemistry/Chemical Engineering ; Springer eBooks
    Pages: : digital
    ISBN: 9783034801256
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  • 11
    Keywords: Life sciences ; Chemistry, Organic ; Nucleic Acids ; Biochemistry ; Life sciences ; Nucleic Acid Chemistry ; Protein Science ; Organic Chemistry ; Springer eBooks
    Pages: : digital
    ISBN: 9783642169311
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  • 12
    Keywords: Life sciences ; Immunology ; Toxicology ; Chemistry, Organic ; Biochemistry ; Cytology ; Life sciences ; Biochemistry, general ; Cell Biology ; Organic Chemistry ; Immunology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Part 1 Glucosyltransferases -- 1 Beta-1,3-glucosyltransferase (B3GALTL) -- 2 Protein O-glucosyltransferases rumi (RUMI) -- 3 UDP-glucose:ceramide glucosyltransferase (UGCG) -- 4 UDP-glucose:glycoprotein glucosyltransferase 1,2 (UGGT1,2) -- Part 2 Galactosyltransferases -- 5 Alpha 1,3-galactosyltransferase 2, pseudogene (A3GALT2P) -- 6 Core 1 beta 3Galactosyltransferase (C1GalT1, T-synthase) and its Specific Molecular Chaperone Cosmc (C1GalT1C1) -- 7 Glycoprotein alpha 1,3-galactosyltransferase 1, pseudogene (GGTA1P) -- 8 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 (B3GALT6) -- 9 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1,2 (B3GALT1,2) -- 10 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (B3GALT4) -- 11 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3GALT5) -- 12 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4GALT1) -- 13 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2-6; xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) (B4GALT2-7) -- 14 UDP-Gal:ceramide galactosyltransferase (UGT8) -- 15 UDP-Gal:lactosylceramide alpha 1,4-galactosyltransferase (A4GALT) -- Part 3 Mannosyltransferases -- 16 Protein O-mannosyl-transferase 1,2 (POMT1,2) -- Part 4 N-Acetylglucosaminyltransferases -- 17 Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT) -- 18 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) -- 19 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltrasnsferase 1 (GCNT1) (C2GnT-L)and Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltrasnsferase 3 (GCNT4) (C2GnT-T) -- 20 Fringe (UDP-GlcNAc: O-fucosylpeptide ß1,3 N-acetylglucosaminyltransferase) -- 21 Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1) -- 22 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A,B (MGAT4A,B) -- 23 Mannosyl (alpha-1,3[6?]-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) (MGAT4C) -- 24 Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT2) -- 25 Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B) -- 26 Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) -- 27 Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N- acetylglucosaminyltransferase (MGAT3); β1,4-N- Acetylglucosaminyltransferase III (GnT-III, GlcNAc-T III) -- 28 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) (IGnT) -- 29 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (OGT) -- 30 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) -- 31 UDP-GlcNAc: beta-Gal beta1,3-N-acetylglucosaminyltransferase 6 (B3GNT6) (Core 3 synthase, C3GnT) -- 32 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1), i-enzyme (iGnT) -- 33 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) -- 34 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) -- 35 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (B3GNT5, Lc3Cer synthase) -- 36 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7) -- 37 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (B3GNT8) -- Part 5 N-Acetylgalactosaminyltransferases -- 38 Beta-1,4 N-acetylgalactosaminyltransferase 1,2 (B4GALNT1,2) -- 39 Beta1,3-N-Acetylgalactosaminyltransferase 2 (B3GALNT2) -- 40 Beta1,4-N-acetylgalactosaminyltransferase-3 (B4GALNT3) and beta1,4-N-acetylgalactosaminyltransferase-4 (B4GALNT4) -- 41 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1) -- 42 Histo-blood Group A and B Transferases, Their Gene Structures, and Common O Group Gene Structures -- 43 Histo-blood Group A Variants, O Variants, and Their Alleles -- 44 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4) -- 45 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) -- Part 6 Fucosyltransferases -- 46 Fucosyltransferase 3. GDP-fucose lactosamine α1,3/4-fucosyltransferase. Lea and Leb histo-blood groups (FUT3, Lewis enzyme) -- 47 Fucosyltransferase 4. GDP-fucose lactosamine α1,3-fucosyltransferase. Myeloid specific (FUT4) -- 48 Fucosyltransferase 5. GDP-fucose lactosamine α3/4-fucosyltransferase (FUT5) -- 49 Fucosyltransferase 6. GDP-fucose lactosamine α3-fucosyltransferase (FUT6) -- 50 Fucosyltransferase 7. GDP-fucose lactosamine α1,3-fucosyltransferase. Sialyl-Lex specific (FUT7) -- 51 Fucosyltransferase 8. GDP-fucose N-glycan core α6-fucosyltransferase (FUT8) -- 52 Fucosyltransferase 9. GDP-fucose lactosamine α1,3-fucosyltransferase. Lex specific (FUT9) -- 53 Fucosyltransferases 1, 2. GDP-fucose galactoside α2-fucosyltransferases. FUT1 or H blood group, FUT2 or ABH secretor status and Sec1 (FUT1, FUT2, Sec1) -- 54 Fucosyltransferases 10, 11. GDP-fucose N-glycan core α1,3-fucosyltransferases (FUT10, FUT11) -- 55 Fucosyltransferases 12, 13: Protein O-fucosyltransferases 1 and 2 (POFUT1, POFUT2) -- Part 7 Sialyltransferases -- 56 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1) -- 57 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (ST3GAL2) -- 58 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (ST3GAL3) -- 59 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4) -- 60 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5) -- 61 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (ST3GAL6) -- 62 ST6 beta-galactoside alpha-2,6-sialyltranferase 1 (ST6GAL1) -- 63 ST6 beta-galactoside alpha-2,6-sialyltranferase 2 (ST6GAL2) -- 64 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) -- 65 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2) -- 66 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3) -- 67 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 (ST6GALNAC4) -- 68 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5,6 (ST6GALNAC5,6) -- 69 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1) -- 70 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2) -- 71 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (ST8SIA3) -- 72 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4) -- 73 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (ST8SIA5) -- 74 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8SIA6) -- Part 8 Glucuronyltransferases -- 75 Beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); beta-1,3-glucuronyltransferase 2 (B3GAT1,2) -- 76 Beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) (B3GAT3) -- Part 9 GAG polymerase and related enzymes -- 77 Chondroitin polymerizing factor, chondroitin polymerizing factor 2, chondroitin sulfate synthase 1,3 (CHPF, CHPF2, CHSY1, CHSY3) -- 78 Chondroitin sulfate N-acetylgalactosaminyltransferase 1,2 (CSGALNACT1,2) -- 79 Dermatan sulfate epimerases (DSE, DSEL) -- 80 Exostoses (multiple)-like 1-3 (EXTL1-3) -- 81 Exostosin 1,2(EXT1,2) -- 82 Heparin-heparansulfate related GlcA C5-epimerase -- 83 Hyaluronan synthase 1-3 (HAS1-3) -- 84 Xylosyltransferase I,II (XYLT1,2) -- Part 10 Sulfotransferases -- 85 Carbohydrate sulfotransferase 10 (CHST10) -- 86 Carbohydrate (chondroitin 4) sulfotransferase 11-13 (CHST11-13) -- 87 Carbohydrate (chondroitin 6) sulfotransferase 3; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 (CHST3,7) -- 88 Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (CHST1) -- 89 Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14) -- 90 Carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 (CHST15) -- 91 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (CHST4) -- 92 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 and 6 (CHST5,6) -- 93 Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2(CHST2) -- 94 Galactose-3-O-sulfotransferase 1-4 (GAL3ST1-4) -- 95 Heparan sulfate 2-O-sulfotransferase (HS2ST) -- 96 Heparan sulfate (glucosamine) 3-O-sulfotransferase 1-6 (HS3ST1-6) -- 97 Heparan-sulfate 6-O-sulfotransferase 1-3 (HS6ST1-3) -- 98 N-Acetylgalactosamine-4-sulfotransferase-1 (GalNAc-4-ST1, CHST8) and N-Acetylgalactosamine-4-sulfotransferase-2 (GalNAc-4-ST2, CHST9) -- 99 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1) -- 100 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2) -- 101 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3,4 (NDST3,4) -- 102 Uronyl-2-sulfotransferase (UST) -- Part 11 Glycosyltransferase-like proteins (inplicated in alpha-dystrogly) -- 103 Fukutin and fukutin-related protein (FKRP) -- 104 Like-glycosyltransferase; glycosyltransferase-like 1B (LARGE, GYLTL1B) -- Part 12 GPI anchor biosynthesis -- 105 Glycosylp
    Abstract: This handbook, now in a new, second edition, is an essential resource for scientists with an interest in the role of glycosyltransferases and related genes involved in the biosynthesis of glycoproteins, glycolipids, and proteoglycans. The first edition of the Handbook of Glycosyltransferases and Related Genes, published in 2002, contained descriptions of more than 100 mammalian genes by over 100 scientists who originally isolated and/or cloned these genes. Since then, there has been a growing body of evidence concerning the roles of glycosyltransferases, and additional glycosyltransferases have been identified. Now more than 200 glycosyltransferases have been isolated from mammalian tissue, corresponding to approximately 1–2% of the total human genome. Some have been found to be involved in development and reproduction, signal transduction, cell death, higher nervous functioning, immunity, and other important biological processes. Glycosyltransferases have also been implicated in the development of lifestyle diseases such as diabetes, cancer, chronic obstructive lung disease (COPD), neuromuscular diseases, and infectious diseases. A functional glycomics approach using gene targeting in mice and analytical methods utilizing glycan arrays, lectin arrays, HPLC, and mass spectrometry identified the target glycoprotein(s) on which glycans are attached by the catalytic reaction of glycosyltransferases. Most of the target proteins have been shown to be cell surface membrane proteins such as growth factor receptors and transporters. The three-dimensional structures of some glycosyltransferases have also been characterized, making it possible to classify them into retaining and inverting enzymes. Such structural information is also included in this invaluable new edition
    Pages: XXXVIII, 1707 p. 205 illus., 75 illus. in color. eReference. : online resource.
    Edition: 2nd ed. 2014.
    ISBN: 9784431542407
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