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  • 1
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: Understanding the functional roles of DNA modifications relies on the accurate detection, quantification, and mapping of DNA modifications. Methods for deciphering DNA modifications have substantially improved over the last several years, which greatly revolutionize the field of DNA modifications. In addition to DNA cytosine methylation (5-methylcytosine, 5mC), the best-characterized epigenetic modification, many new modifications have been discovered to present in DNA in recent years. This book provides a comprehensive overview of available techniques and methods together with detailed step-by-step protocols for experimental procedures required to successfully perform analysis on various types of DNA modifications, including 5mC, 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxycytosine (5caC), 5-hydroxymethyluracil (5hmU), 5-formyluracil (5fU), N6-methyladenine (6mA), β-D-glucosyl-5-hydroxymethyluracil (base J) and 8-oxo-7,8-dihydroguanine (OG). This laboratory manual is a valuable source for biochemists and molecular biologists from different fields who wish to investigate DNA modifications.
    Type of Medium: Online Resource
    Pages: VI, 194 p. 48 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071612293
    Series Statement: Springer Protocols Handbooks,
    Language: English
    Note: Part 1. Detection of 5mC, 5hmC, 5fC, and 5caC -- Chapter 1. Quantitative assessment of the oxidation products of 5-methylcytosine in DNA by liquid chromatography-tandem mass spectrometry -- Chapter 2. Determination of cytosine modifications in DNA by chemical labeling-mass spectrometry analysis -- Chapter 3. Analysis of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA by capillary electrophoresis-mass spectrometry -- Chapter 4. Simple quantification of epigenetic DNA modifications and DNA damage on multi-well slides -- Chapter 5. Label-free and immobilization-free electrochemical magnetobiosensor for sensitive detection of 5-hydroxymethylcytosine in genomic DNA -- Chapter 6. Electrochemical assay for continuous monitoring of dynamic DNA methylation process -- Chapter 7. Electrogenerated chemiluminescence method for determination of 5‑hydroxymethylcytosine in DNA -- Chapter 8. Quantification of site-specific 5-formylcytosine by integrating peptide nucleic acid-clamped ligation with loop-mediated isothermal amplification -- Chapter 9. Global DNA methylation analysis using methylcytosine dioxygenase -- Part 2. Detection of 6mA -- Chapter 10. Metabolically generated stable isotope for identification of DNA N6-methyladenine origin in cultured mammalian cells -- Chapter 11. Determination of N6‑methyladenine in DNA of mammals and plants by Dpn I digestion combined with size-exclusion ultrafiltration and mass spectrometry analysis -- Part 3. Detection of 5hmU and 5fU -- Chapter 12. Isotope-dilution liquid chromatography-tandem mass spectrometry for detection of 5-hydroxymethyluracil and 5-formyluracil in DNA -- Chapter 13. Detection of 5 Formylcytosine and 5 Formyluracil based on Photo-assisted Domino Reaction -- Chapter 14. Detection of 5-formyluracil and 5-formylcytosine in DNA by fluorescence labelling -- Part 4. Detection of Base J and 8-oxo-7, 8-dihydroguanine -- Chapter 15. Mass spectrometry-based quantification of β-D-glucosyl-5-hydroxymethyluracil in genomic DNA -- Chapter 16. Determination of 8-oxo-7,8-dihydroguanine in DNA at single-base resolution by polymerase-mediated differential coding.
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  • 2
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This detailed book explores protocols with the aim of testing aerobic exercise, resistance training, special diets, additives and natural products, which have led to new insights into the physiological and molecular aspects of health and disease. Many of these approaches have contributed to significant improvements in disease areas such as cardiovascular disease, cognitive dysfunction, diabetes, frailty, gliobastoma, metabolic syndrome, obesity, oxidative stress, and various cancers. This collection also provides important information on disease mechanisms and novel drug targets as each protocol is presented in the context of specific chronic diseases or different therapeutic areas. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and reflective of research from all around the globe, Physical Exercise and Natural and Synthetic Products in Health and Disease serves as an ideal guide for researchers in the areas of chronic disease, exercise, and nutrition, as well as to clinical scientists, physicians, and pharmacologists as it gives insights into possibilities for the development of novel therapeutics and the means of monitoring therapeutic response through the measurement of molecular and physiometric biomarkers.
    Type of Medium: Online Resource
    Pages: XIV, 403 p. 83 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071615584
    Series Statement: Methods in Molecular Biology, 2343
    Language: English
    Note: The New Frontier of Three-Dimensional Culture Models to Scale Up Cancer Research‎ -- Therapeutic Effects of Resveratrol on Non-Alcoholic Fatty Liver Disease through Inflammatory, Oxidative Stress, Metabolic, and Epigenetic Modifications -- A Matter of Fat: Body Fat Distribution and Cardiometabolic Disease in Africa -- PGK1: An Essential Player in Modulating Tumor Metabolism -- The Association of Reproductive Aging with Cognitive Function in Sub-Saharan African Women -- The Effects of Exercise on Lipid Biomarkers -- Exercise Training Protocols to Improve Obesity, Glucose Homeostasis, and Subclinical Inflammation -- A Protocol of Intradialytic Exercise for Improvements in Inflammatory Status, Body Composition, and Functional Capacity -- Evaluating the Anticancer Activity of Natural Products Using a Novel 3D Culture Model -- Evaluation of Antidiabetic Properties of Adenosma bracteosum Bonati Extracts in Mice with Streptozotocin-Induced Diabetes -- Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide -- Proteomic Mapping of the Human Myelin Proteome -- Testing for Thyroid Peroxidase and Anti-Neuronal Antibodies in Depression and Schizophrenia -- Evaluation of Antimicrobial and Anticancer Activities of Bouea macrophylla Ethanol Extract -- Evaluation of Anti-Hepatocellular-Cancer Properties of β-Sitosterol and β-Sitosterol-Glucoside from Indigofera zollingeriana Miq -- Label-Free Electrochemical Biosensors to Evaluate the Antioxidant Effect of Tocopherol in Ultraviolet Radiation -- qRT-PCR Analysis of GLUT-4 and Assessment of Trolox as an Effective Antioxidant in Diabetic Cardiomyoblasts -- Flow Cytometric Analysis of Hyperglycemia-Induced Cell Death Pathways in Cardiomyoblasts -- Vietnamese Medicinal Plants as Potential Resources to Explore New Anti-Cancer and Anti-Inflammation: Established Assays for Pharmacological Tests -- Testing the Effect of Curcumin on Proliferative Capacity of Colorectal Cancer Cells -- Assessment of Topical and Transdermal Penetration of Curcuma heyneana Rhizome Extract in Rat Skin: Histological Analysis -- Measuring the Effects of Berberine on Serum Pro-Oxidant–Antioxidant Balance in Metabolic Syndrome -- Testing the Anti-Inflammatory Effects of Curcuminoids in Patients with Colorectal Cancer -- Analytical Methods and Bioassays for Cytotoxicity and Anti-Diabetic Properties of Aquilaria Crassna Leaf Extracts in HepG2 Cells -- Testing the Physical and Molecular Effects of Nutritional Supplements and Resistance Exercise in Middle-Aged Females -- Analysis of Cytotoxic Effects of Zerumbone in Malignant Glioblastoma Cells -- Protocol for Testing the Potential Antioxidant Effects of Curcuminoids on Patients with Type 2 Diabetes Mellitus -- The Detection of Toxic Compounds in Extracts of Callilepis laureola (Ox-Eye Daisy) and Senecio latifolius (Ragwort) by Ultra-Performance Liquid Chromatography Mass Spectrometry (UPLC-MS/MS) -- Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake.
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  • 3
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Antibodies: Methods and Protocols serves as an ideal guide for researchers working with the production of, research on, and development of therapeutic antibodies as well as for clinicians using therapeutic antibodies in daily work with patients.
    Type of Medium: Online Resource
    Pages: XIII, 347 p. 71 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071614501
    Series Statement: Methods in Molecular Biology, 2313
    Language: English
    Note: Therapeutic Antibodies: An Overview -- Treatment of Autoimmune Diseases with Therapeutic Antibodies: Lessons Learned from PID Patients Allow for Stratification of the Infection Risk -- B-Cell Analysis for Monitoring Patients Undergoing B-Cell Depletion for the Treatment of Autoimmune Diseases -- Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods -- The Therapeutic Antibody Profiler for Computational Developability Assessment -- Short Read-Length Next-Generation DNA Sequencing of Antibody CDR Combinations from Phage Selection Outputs -- Large Scale Transient Production in ExpiCHO-STM with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection -- Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia pastoris -- Purification of Therapeutic Antibodies by Protein A Affinity Chromatography -- Ion Exchange Chromatographic Methods for Purification of Therapeutic Antibodies -- Structure-Indicated LC-MS/MS Bioanalysis of Therapeutic Antibodies -- Use of PASEF for Accelerated Protein Sequence Confirmation and De Novo Sequencing with High Data Quality -- Nano-Microscopy of Therapeutic Antibody Aggregates in Solution -- Measuring Self-Association of Antibody Lead Candidates with Dynamic Light Scattering -- Intact Mass Quantitation of Therapeutic Antibodies for Pharmacokinetic Studies Using Immuno-Purification -- Detection of Residual Host Cell Proteins in Biotherapeutic Drugs by Concatenated 2D LC-MS/MS -- Bioassays for the Evaluation of Target Neutralization and Complement-Dependent Cytotoxicity (CDC) of Therapeutic Antibodies -- Methods for Functional Characterization of FcRn Interactions with Therapeutic Antibodies and Fc-Fusion Proteins -- Method for Measurement of Antibody-Dependent Cellular Phagocytosis -- Bioluminescent Bridging Immunoassay for Anti-Drug Antibody (ADA) Detection -- A Surface Plasmon Resonance-Based Assay for Simultaneous Measurement of Serum Concentrations of Therapeutic Antibodies and Anti-Drug Antibodies.
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  • 4
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest techniques used for sustainable development of eco-friendly pest management systems. Chapters in this book look at the design of novel RNAi-mediated pest control strategies and related issues. Some of the topics covered in this book are identification and characterization of differentially expressed non-coding RNAs in insect genomes; functional small RNA design; analysis of endogenous RNAi pathways; RNAi screening; plant models of RNAi-mediated pest control; and dsRNA delivery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNAi Strategies for Pest Management: Methods and Protocols is a valuable resource for any scientist or researcher interested in learning more about this exciting and developing field. Chapter 18 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XIV, 369 p. 63 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071616338
    Series Statement: Methods in Molecular Biology, 2360
    Language: English
    Note: Genome-Wide Identification and Functional Characterization of Non-Coding RNAs (ncRNAs) Differentially Expressed during Insect Development -- Identification and Functional Characterization of Argonaute (Ago) Proteins in Insect Genomes -- Functional Characterization of Silkworm PIWI Proteins by Embryonic RNAi -- Guiding RNAi Design through Characterization of Endogenous Small RNA Pathways -- Silencing of Molecular Targets with Relevance to Insecticide Resistance in Colorado Potato Beetle using dsRNA -- Visualization of RNA Transcripts in Western Corn Rootworm (Diabrotica virgifera virgifera) and Plants by In Situ Hybridization -- In Silico Screening of Attractive Target Genes for RNAi-Based Pest Control -- RNAi Feeding Bioassay: A Protocol for dsRNA Screening against Asian Citrus Psyllid and Related Hemipteran Insects -- A Random-Screening Approach to Identify RNAi Targets for the Control of Western Corn Rootworm (Diabrotica. virgifera virgifera Le Conte) -- Rapid Screening of Myzus persicae (Green Peach Aphid) RNAi Targets using Tobacco rattle virus -- Genome-Wide Identification and Validation of Target Genes Associated with Insecticide Treatment of the Green Peach Aphid, Myzus persicae -- Inhibition of Rhopalosiphum maidis (Corn Leaf Aphid) Growth on Maize by Virus-Induced Gene Silencing with Sugarcane mosaic virus -- RT-qPCR for Detection and Expression Monitoring of Core Genes Involved in the RNA Interference Pathways of Western Corn Rootworm (Diabrotica virgifera virgifera) -- Examination of the Suitability of Attractive Target Genes for RNAi-Based Pest Control -- Functional Characterization of Target Genes Associated with Insecticide Resistance of the Green Peach Aphid, Myzus persicae -- Plant-Mediated RNA Interference Expressing dsRNA in Cytoplasm for RNAi-Based Pest Control -- RNAi Expression in Cotton for Control of Herbivorous Insects -- Transplastomic Tomato Plants Expressing Insect-Specific Double-Stranded RNAs: A Protocol Based on Biolistic Transformation -- Double-Strand RNA (dsRNA) Delivery Methods in Insects: Diaphorina citri -- Delivery of Double-Stranded RNAs (dsRNAs) Produced by Escherichia coli HT115 (DE3) for Non-Transgenic RNAi-Based Insect Pest-Management -- Symbiont-Mediated RNA Interference (SMR): Using Symbiotic Bacteria as Vectors for Delivering RNAi to Insects -- Application of Nanoparticle-Mediated RNAi for Efficient Gene Silencing and Pest Control on Soybean Aphids -- Methods for Delivery of dsRNAs for Agricultural Pest Control: The Case of Lepidopteran -- The CRISPR/Cas9-Mediated Genome Editing System in Insect Genomics and Pest Management.
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  • 5
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to fabricate OoC devices such as, standard photo- and soft-lithography, techniques to fabricate membranes, and industrial-oriented fabrication methods.Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Organ-On-a Chip: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
    Type of Medium: Online Resource
    Pages: XII, 322 p. 83 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071616932
    Series Statement: Methods in Molecular Biology, 2373
    Language: English
    Note: Photo and Soft Lithography for Organs-on-Chip applications -- Organs-on-chips for Studying Tissue Barriers: Standard Techniques and a Novel Method for Including Porous Membranes Within Microfluidic Devices -- Thermoplastic microfluidics -- Bile Duct-On-a-Chip -- Establishment of a Modular Anaerobic Human Intestine Chip -- Intestinal Epithelium Tubules on a Chip -- A Human Neurovascular Unit On-a-chip -- Generation of a Glomerular Filtration Barrier on a Glomerulus-on-a-chip Platform -- Electro-Mechanical Stimulation of 3D Cardiac Microtissues in a heart-on-chip Model -- Miniaturized Vascularized Bleeding Model of Hemostasis -- Fabrication and Use of a Pumpless Microfluidic Lymphatic Vessel Chip -- On Chip-Platelet Activation Assessment: Microfluidic Emulation of Shear Stress Profiles Induced by Mechanical Circulatory Support Devices -- Biofabrication of 3D Human Muscle Model with Vascularization and Endomysium -- Mechanical induction of Osteoarthritis traits in a cartilage-on-chip model -- A Synovium/Cartilage-On-A-Chip Model To Investigate The Process Of Monocyte Extravasation -- A Mesoscale 3D Culture System For Native And Engineered Biphasic Tissues: Application To The Osteochondral Unit -- 3D biofabricated in Vitro Models of Vascularized and Mineralized Bone Tissues -- Isolation, Integration, and Culture of Human Mature Adipocytes Leveraging Organ-On-Chip Technology. .
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  • 6
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume presents a wide range of techniques for plant mitochondrial analysis, ranging from tried-and-tested work horse techniques to the latest innovations. Within its pages, it explores subjects such as affinity-based isolation of mitochondria with magnetic beads, mitochondrial quality assessment protocols, measurement of uptake and release of specific metabolites, mitochondrial protein identification and visualization, as well as gene splicing and editing, and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Mitochondria: Methods and Protocols provides a highly useful set of methodologies for the plant mitochondrial community to help discover more interesting aspects of plant mitochondria in the years to come.
    Type of Medium: Online Resource
    Pages: XIII, 342 p. 67 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071616536
    Series Statement: Methods in Molecular Biology, 2363
    Language: English
    Note: Purification of Leaf Mitochondria from Arabidopsis thaliana Using Percoll Density Gradients -- Cell Type-Specific Isolation of Mitochondria in Arabidopsis -- Isolation of Plant Mitochondria Using Affinity Purification -- Isolation of Highly Purified, Intact, and Functional Mitochondria from Potato Tubers Using a Two-in-One Percoll Density Gradient -- Integrity Assessment of Isolated Plant Mitochondria -- High-Throughput Oxygen Consumption Measurements in Leaf Tissue Using Oxygen Sensitive Fluorophores -- Assessment of Respiratory Enzymes in Intact Cells by Permeabilization with Alamethicin -- Assessing the Kinetics of Metabolite Uptake and Utilization by Isolated Mitochondria Using Selective Reaction Monitoring-Mass Spectrometry (SRM-MS) -- Complexome Profiling of Plant Mitochondrial Fractions -- High Throughput BN-PAGE for Mitochondrial Respiratory Complexes -- Assessment of Mitochondrial Protein Composition and Purity by Mass Spectroscopy -- Mitochondrial GFP-Tagged Protein Localization Using Transient Transformations in Arabidopsis thaliana -- Assessment of Mitochondrial Protein Topology and Membrane Insertion -- Assessment of Protein Synthesis in Mitochondria Isolated from Rosette Leaves and Liquid Culture Seedlings of Arabidopsis -- Markers for Mitochondrial ROS Status -- Mass Spectrometry-Based Quantitative Cysteine Redox Proteome Profiling of Isolated Mitochondria Using Differential iodoTMT Labeling -- Analysis of the Plant Mitochondrial Transcriptome -- Quantification of Mitochondrial RNA Editing Efficiency Using Sanger Sequencing Data -- Nascent Transcript Sequencing for the Mapping of Promoters in Arabidopsis thaliana Mitochondria -- Assessment of Mitochondrial DNA Copy Number, Stability, and Repair in Arabidopsis -- Measuring the Activity of DNA Repair Enzymes in Isolated Mitochondria -- MitoTALENs: A Method for Targeted Gene Disruption in Plant Mitochondrial Genomes.
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  • 7
    In: Springer Nature eBook
    Description / Table of Contents: This volume presents state-of-the art design, analysis and integration approaches for biomedical data including novel statistical models for a comprehensive and powerful synthesis and assessment of scientific evidence. Chapters detail principles of systematic reviews, semi-automated tools for systematic searches, fixed- and random-effects meta-analytical models, living systematic reviews, meta-analysis of genetic studies, meta-analysis of pragmatic and explanatory trials, network meta-analysis, and other modern approaches for data synthesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Meta- Research: Methods and Protocols book, written by global experts, will introduce the reader in a step-by-step process to the methods of the vital and highly promising field of evidence synthesis.
    Type of Medium: Online Resource
    Pages: XI, 318 p. 40 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071615669
    Series Statement: Methods in Molecular Biology, 2345
    Language: English
    Note: Principles of Systematic Reviews and Meta-Analyses -- Semi-automated Tools for Systematic Searches -- Fixed- and Random-effects Models -- Assessing Heterogeneity in Random-Effects Meta-Analysis -- Performing Meta-Analyses with Very Few Studies -- Systematic vs Rapid vs Scoping Reviews -- Living Systematic Reviews -- Umbrella Reviews: What They Are and Why We Need Them -- Meta-analysis of Genetics Studies: Assessing Common and Rare Variation -- Meta-analysis of Pragmatic and Explanatory Trials -- Meta-analysis of Proportions -- Meta-Analysis Methods of Diagnostic Test Accuracy Studies -- Network Meta-Anaylsis -- Contrast-based and Arm-Based Models for Network Meta-Analysis -- Software to Conduct a Meta-Analysis and Network Meta-Analysis -- Modelling Multicomponent Interventions in Network Meta-analysis -- Practical Considerations and Challenges when Conducting an Individual Participant Data(IPD) Meta-Analysis -- Individual Patient Data Meta-Analysis and Network Meta-Analysis -- Challenges in Comparative Meta-Analysis of the Accuracy of Multiple Diagnostic Tests.
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  • 8
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: The fourth edition provides new and updated chapters that focus on experimental models, useful for investigating various aspects of cytoskeleton structure and function. Chapters detail protocols on animal models, plant models, protist models, fungal models, live and fixed-cell imaging, dynamics of cytoskeleton components, cell and organelle motility, genetics, and proteomics. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Cytoskeleton: Methods and Protocols, Fourth Edition aims to provide an updated version to help researchers expand their understanding of cytoskeleton structure and function.
    Type of Medium: Online Resource
    Pages: XI, 430 p. 65 illus., 34 illus. in color. , online resource.
    Edition: 4th ed. 2022.
    ISBN: 9781071616611
    Series Statement: Methods in Molecular Biology, 2364
    Language: English
    Note: Super Resolution Imaging of the Actin Cytoskeleton in Living Cells Using TIRF-SIM -- Imaging Cytoskeleton Components by Electron Microscopy -- Imaging the Actin Cytoskeleton in Live Budding Yeast Cells -- Imaging the Actin Cytoskeleton in Fixed Budding Yeast Cells -- Imaging of actin cytoskeletal integrity during aging in C. elegans -- Imaging the Cytoskeleton in Living Plant Roots -- Imaging of Actin Cytoskeleton in the Nematode Caenorhabditis elegans -- Imaging of the Cytoskeleton using Live and Fixed Drosophila Tissue Culture Cells -- Influencing the Actin-Dynamics in Plant Cells by Jasplakinolide, Chondramides, Phalloidin, Cytochalasins, and Latrunculins -- Analysis of Morphogenesis and Flagellar Assembly During Spermatogenesis in Planarian Flatworms -- ­An In Vitro Model System to Test Mechano-Microbiological Interactions Between Bacteria and Host Cells -- Purification of Cytoskeletal Proteins by Fast Protein Liquid Chromatography (FPLC) Using an ÄKTA Start System -- The Cilioprotist Cytoskeleton, a Model for Understanding How Cell Architecture and Pattern Are Specified: Recent Discoveries from Ciliates and Comparable Model Systems -- 3D and 4D Tumorigenesis Model for the Quantitative Analysis of Cancer Cell Behavior and Screening for Anti-Cancer Drugs -- Melanosome Motility in Fish Retinal Pigment Epithelial (RPE) Cells -- Chemotaxis: Under Agarose Assay -- Functional Analysis of Actin-Binding Proteins in the Central Nervous System of Drosophila -- Using a Hand-Held Gene Gun for Genetic Transformation of Tetrahymena thermophila -- Proteomic Tools for Analysis of Cytoskeleton Proteins.
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  • 9
    In: Springer Nature eBook
    Description / Table of Contents: This book provides readers with a comprehensive overview of cold plasma technology for tackling the various food-related hazards in a wide range of food sectors. The principles and characteristics of cold plasma generation in gas and its interaction with liquids, as well as its combating modes of action for common hazards (e.g., bacteria, spores, biofilms, fungi, and fungal toxins) are emphasized in this book. It also presents the applications of cold plasma or its hurdles with other techniques to assure the microbiological safety of the key food classifications, including fruits, vegetables, cereals, grains, meat, aquatic products, liquid food products (e.g., juices, milk), nuts, spices, herbs, and food packaging. This book is useful for researchers to grasp the comprehensive understandings of how food safety can be controlled with cold plasma technology. This book also provides adequate information for engineers in food industry for better development and optimization of the plasma-generating systems. Government institutions that are responsible for food safety regulations can understand more knowledge about the intricacies and influencing factors, which should be considered for regulating the applications of cold plasma technology in food.
    Type of Medium: Online Resource
    Pages: IX, 355 p. 51 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811618277
    Language: English
    Note: 1 Principles and characteristics of cold plasma -- 2 Systems for generation of cold plasma -- 3 Inactivation of bacteria by cold plasma -- 4 Antibiofilm application of cold plasma in food safety -- 5 Inactivation of fungi and fungal toxins by cold plasma -- 6 Abatement of food allergen by cold plasma -- 7 Application of cold plasma in fruits and vegetables -- 8 Application of cold plasma in cereals and grains food -- 9 Application of cold plasma in animal meat and poultry -- 10 Applications of cold plasma on aquatic products -- 11 Application of cold plasma in liquid food products -- 12 Application of cold plasma in nuts, spices, and herbs -- 13 Application of cold plasma in food packaging -- 14 Cold plasma hurdled strategies for food safety applications -- 15 Safety evaluation of cold plasma technology -- 16 Future outlooks.
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  • 10
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: This new edition presents a fully-updated and expanded look at current Good Manufacturing Practice (cGMP) for cell therapy products. It provides a complete discussion of facility design and operation including details specific to cord blood banking, cell processing, vector production and qualification of a new facility. Several chapters cover facility infrastructure including cleaning and maintenance, vendor qualification, writing a Standard Operating Procedure, staff training, and process validation. The detailed and invaluable product information covers topics like labelling, release and administration, transportation and shipment, et al. Further chapters cover relevant topics like writing and maintaining investigational new drug applications, support opportunities in North America and the European Union, commercial cell processing and quality testing services, and financial considerations for academic GMP facilities. A chapter on future directions rounds out Cell Therapy: cGMP Facilities and Manufacturing making it essential reading for any cell therapy professional involved in the development, use, or management of this type of facility. .
    Type of Medium: Online Resource
    Pages: X, 692 p. 107 illus., 75 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030755379
    Language: English
    Note: Part 1. Regulatory.-1. Regulation of Cell Therapy in the United States.-2. Regulatory Landscape and Emerging Trends In Advanced Therapies Manufacturing: An EU Perspective.-3. Australian Cellular Therapy Regulations -- 4. Landscape for Regenerative Medicine Manufacturing in Japan -- 5. GLP Regulations for Non-clinical studies -- 6. Ethical Considerations in Cell Therapy -- 7. Investigational New Drug Applications for Cell Therapy Products -- 8. FDA Inspections -- 9. Commercialization of Investigational Cell Therapy Products -- Part 2 Quality Systems -- 10. The Meaning of Quality -- 11. Development and Maintenance of a Quality Program -- 12. Quality Control of Cellular Therapy Products and Viral Vectors -- 13. Quality Management Software – Q-Pulse -- 14. Selection of Contract Manufacturing and Testing Organizations -- Part 3 Facility Design -- 15. Introduction: Facility Design -- 16. PACT CPFs - Examples Describing Different Cell Processing Facility Designs -- 17. Design and Operation of a Multiuse GMP Facility at the City of Hope -- 18. Design and Operation of a Multiuse GMP Facility at the University of Miami -- 19. Design of a New Academic GMP Facility for Today and Beyond at the Dana-Farber Cancer Institute -- 20. Design and Licensure of an American Cord Blood Bank -- 21. Indiana University Vector Production Facility (IUVPF) -- 22. Qualification and Commissioning of a New GMP Facility -- Part 4 Facility Infrastructure -- 23. Environmental Monitoring -- 24. GMP Facility Cleaning and Maintenance -- 25. GMP Documentation -- 26. Process Validation -- 27. Equipment Qualification -- 28. Vendor Qualification and Supply Management -- 29. Staffing, Training and Competency -- Part 5 Product Management -- 30. Product Accessioning, Tracing and Tracking -- 31. ISBT 128 in Labeling of Cellular Therapy Products -- 32. Product Processing, Manufacturing and Administration -- 33. Transport and Shipment of Cellular and Gene Therapy Products -- 34. Regenerative Medicine: The Newest Cellular Therapy -- 35. Cellular Therapy Applications for COVID-19 -- Part 6 Professional Standards and Support Organizations -- 36. Professional Standards for Cellular Therapy: The Foundation for the Accreditation of Cellular Therapy (FACT) -- 37. AABB Cell Therapy Standards -- 38. USP Standards for Cell-based Therapies -- 39. The Role of the National Institute of Standards Measurement Assurance for Cell Therapies -- 40. National Science Foundation Engineering Research Center for Cell Manufacturing Technologies (CMaT) -- 41. Financial Considerations for Academic GMP Facilities -- 42. Governmental Support Opportunities for Cellular & Gene Therapies in the United States.
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  • 11
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: Agriculture and food systems, forestry, the marine and the bio-based sectors are at the very heart of the climate change crisis. Evidence on climate change reveals that it will affect farming first, through changes to rainfall regimes, rising temperatures, the variability and seasonality of the climate and the occurrence of more frequent extreme events (heatwaves, droughts, storms and floods). In addition to findings ways to mitigate greenhouse gas emissions, farmers will need to develop farming systems resilient to fluctuating environmental and socioeconomic conditions. It is thus a great challenge to support ambitious climate targets while satisfying the needs for food, feed, bio-based products and energy for a global population projected to reach 10 billion by 2030. Few books on the market integrate environment studies and climate-smart food production. This book fills the knowledge gap by covering all the relevant aspects in one reference: starting with microclimate management, climate change and food systems, and resilience of mixed farming and agroforestry systems, chapters address agricultural soil management, integrated water management in small agricultural catchments, citizen-driven food system approaches in cities, and ICT-enabled agri-food systems. By focusing on the most recent advances in the field while analyzing the potential of already applied practices, this book can serve as a handbook for regulators and researchers looking to understand all aspects of food production and distribution in this changing environment.
    Type of Medium: Online Resource
    Pages: X, 427 p. 65 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030715717
    Language: English
    Note: 1. Microclimate management: From traditional agriculture to livestock systems in tropical environments -- 2. Climate-smart and agro-ecological farming systems of smallholder farmers -- 3. The telecoupling approach to the Global Food System and Climate Change Regime: the pivotal role of Brazil and China -- 4. Genetic Resources -- 5. PLANT ADAPTATION TO ENVIRONMENTAL STRESS: DROUGHT, CHILLING, HEAT, AND SALINITY -- 6. Innovations in Plant Variety Testing with Entomological and Statistical Interventions -- 7. Global Resource Flows in the Food System -- 8. Vertical Farming: An AI-based Micro-System with Economic Data -- 9. Challenges and Opportunities of Digital Technology in Soil Quality and Land Management Research -- 10. High-Quality Fertilizers from Biogas Digestate -- 11. Citizen-driven food system approaches in cities -- 12. ICT-enabled agri-food systems.
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  • 12
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.
    Type of Medium: Online Resource
    Pages: XII, 218 p. 74 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071617632
    Series Statement: Neuromethods, 175
    Language: English
    Note: The Physiological Basis of Cerebrovascular Reactivity Measurements -- Experimental Protocols in CVR Mapping -- Molecular Imaging of Cerebrovascular Reactivity -- Measurement of Cerebrovascular Reactivity using Transcranial Doppler -- The Role of Cerebrovascular-Reactivity Mapping in Functional MRI: Calibrated fMRI and Resting-State fMRI -- Hemodynamic Evaluation of Paradoxical Blood Oxygenation-Level Dependent Cerebrovascular Reactivity with Transcranial Doppler and MR-Perfusion in Patients with Symptomatic Cerebrovascular Steno-Occlusive Disease -- Cerebrovascular Reactivity (CVR) in Aging, Cognitive Impairment, and Dementia -- Magnetic Resonance Imaging Methods for Assessment of Hemodynamic Reserve in Chronic Steno-Occlusive Cerebrovascular Disease -- Breath-Hold Cerebrovascular Reactivity Mapping for Neurovascular Uncoupling Assessment in Primary Gliomas -- Clinical Translation of Cerebrovascular Reactivity Mapping -- Recent Advances and Future Directions: Clinical Applications of Intraoperative BOLD-MRI CVR.
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  • 13
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This third edition provides new and updated chapters on design PCR primers for successful DNA amplification. Chapters are divided into seven parts, including primer design strategies for quantitative PCR, genotyping, multiplex PCR, in silico PCR primer design, and primer design to identify plant and animal viruses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, PCR Primer Design, Third Edition aims to be useful for various fields of molecular biology, including biotechnology, molecular genetics, and recombinant DNA technology.
    Type of Medium: Online Resource
    Pages: XIII, 276 p. 90 illus. , online resource.
    Edition: 3rd ed. 2022.
    ISBN: 9781071617991
    Series Statement: Methods in Molecular Biology, 2392
    Language: English
    Note: The significance of PCR primer design in genetic diversity studies; exemplified by recent research into the genetic structure of marine species -- Enhancing cohort PASA efficiency from lessons assimilated by mutant genotyping in C. elegans -- Design of oligonucleotides for allele-specific amplification based on PCR and isothermal techniques -- Detection of rubella virus by tri-primer RT-PCR assay and genotyping by fragment RT-PCR -- Design of mismatch primers to identify and differentiate closely related (sub)species – application to the authentication of meat products -- Primer design for the analysis of closely related species – application of non-coding mtDNA and cpDNA sequences -- Designing PCR primers for the amplification-refractory mutation system -- Validation of circular RNAs by PCR -- Primer Designing for Amplifying an AT-Rich Promoter from Arabidopsis thaliana -- PLASmid TAXonomic PCR (PlasTax-PCR), a multiplex relaxase MOB typing to assort plasmids into taxonomic units -- Multiplex PCR Design for Scalable Resequencing -- Identification of gene copy number in the transgenic plants by quantitative polymerase chain reaction (qPCR) -- qPrimerDB: A powerful and user-friendly database for qPCR primer design -- PCR primer design for the rapidly evolving SARS-CoV-2 genome -- Universal primers for detection of novel plant capsid-less viruses: Papaya umbra-like viruses as example -- A guide to using FASTPCR software for PCR, in silico PCR, and oligonucleotide analysis -- Pyrosequencing Primer Design for Forensic Biology Applications.-Phosphate‌ ‌methylated‌ ‌oligonucleotides‌ ‌as‌ ‌a‌ ‌novel‌ ‌primer‌ ‌for‌ ‌PCR‌ ‌and‌ ‌RT-PCR‌. .
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  • 14
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    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This third edition summarizes the most important areas of Cell-Penetrating Peptides (CPP) research. Chapters are divided into three parts detailing the historical background of CPP, the classifications of the available CPPs, approaches for prediction of novel CPPs, methods for studies of “naked” CPPs, and a brief summary of functionality issues of CPPs, both in vitro and in vivo. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Cell Penetrating Peptides: Methods and Protocols, Third Edition aims to be a useful practical guide to researches to help further their study in this field.
    Type of Medium: Online Resource
    Pages: XX, 632 p. 103 illus., 89 illus. in color. , online resource.
    Edition: 3rd ed. 2022.
    ISBN: 9781071617526
    Series Statement: Methods in Molecular Biology, 2383
    Language: English
    Note: Cell-penetrating peptides -- Shuttling homeoproteins and their biological significance -- Artificial evolutionary optimization process to improve the functionality of CPPs -- In silico design of chemically modified cell penetrating peptides -- Synthetic Molecular Evolution of Cell Penetrating Peptides -- A native CPP from rattlesnake with therapeutic and theranostic properties -- Synthesis of cell-penetrating peptide coated silica nanoparticles and their physicochemical and biological characterization -- Enhancing the therapeutic potential of extracellular vesicles using peptide technology -- Challenges and methods for the study of CPP translocation mechanisms -- Membrane molecular interactions and induced structures of CPPs -- A single GUV method for revealing the action of cell-penetrating peptides in biomembranes -- Methods for Small-Angle Scattering Measurements on Peptiplexes of DNA with Cell-Penetrating Peptides -- Imaging CPP delivery mechanisms of oligonucleotides -- Quantitative subcellular analysis of cyclic cell-penetrating peptide EJP18 in non-adherent cells -- PepFect14: signaling and transfection -- Utilisation of cell-penetrating peptides for in vivo delivery of bioactive cargo – the effect of nanoparticle formulation -- Protein delivery by PTDs/CPPs -- Protein Delivery to Cytosol by Cell-Penetrating Peptide Bearing a Tandem Repeat Penetration-Accelerating Sequence -- Recombinant transcription factors (TFs) fused to ZEBRA minimal transduction domain (MD) for modulation of mRNA transcripts -- Protein mimicry and the design of bioactive cell penetrating peptides: The genesis of STOPSPERM bioportides -- Lipopeptide pepducins as therapeutic agents -- Delivery of Antibiotics by Cell-Penetrating Peptides to Kill Intracellular Pathogens -- CPP applications in immune modulation and disease therapy -- Cell-penetrating peptides as carriers for transepithelial drug delivery -- New tools for streamlined in vivo homing peptide identification -- Tumor targeting as new therapeutic approach -- Mitochondrial Targeting Probes, drug conjugates and gene therapeutics -- Novel brain penetrating single chain antibodies directed against 3RTau for the Treatment of Alzheimer’s Disease and related Dementias -- Strategies for peptide-mediated cargo delivery to human smooth muscle cells -- Tips and Tools to Understand Direct Membrane Translocation of siRNA-Loaded WRAP-Based Nanoparticles -- Evaluating efficacy of peptide-delivered oligonucleotides using the severe Taiwanese SMA mouse model -- Development of CPP-based methods for delivery of miRNAs into the skin and airways - lessons from cell culture and mouse models -- Endpoint and kinetic approaches for assessing transfection efficacy in mammalian cell culture -- Tissue analysis of lung-targeted delivery of siRNA and plasmid DNA -- Improvement of transfection with PepFects by organic and inorganic components -- DNA Transfer into Animal Cells Using Stearylated CPP Based Transfection Reagent -- Use of PepFect14 and siRNA for targeted gene silencing in human embryonic stem cells -- CRISPR/Cas9 plasmid delivery through the CPP: PepFect14 -- Applications of CPPs in genome editing of plants -- Live Cell Genomics: Cell-specific transcriptome capture and exon-specific RNA binding protein isolation in live tissues and cells.
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  • 15
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    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This laboratory manual includes the latest tools and techniques involved in genomic research. It starts with an introductory chapter on genomics and the various tools and applications involved. The initial chapters present protocols for basic techniques such as DNA isolation, electrophoresis, PCR, cDNA synthesis etc. The book then goes on to describe more advanced techniques such as next-generation sequencing, exome sequencing, use of RNAi, RNAseq, genome editing, single cell genomics etc. Each topic includes a brief description, information on the principles involved, materials & methods, protocol, and expected results, with diagrams and graphs. All protocols are presented in a very lucid and precise way, to make it easy for readers to follow and replicate them.
    Type of Medium: Online Resource
    Pages: XXIX, 720 p. 254 illus., 176 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071618189
    Series Statement: Springer Protocols Handbooks,
    Language: English
    Note: Chapter 1: Conventional and Basic genomic techniques -- Chapter 2: Recombinant DNA technology -- Chapter 3: Mitochondrial Genetics -- Chapter 4: Basic principle of Cloning -- Chapter 5: Immunohistochemistry -- Chapter 6: Western blotting -- Chapter 7: Introduction to Bioinformatics -- Chapter 8: Molecular evolutionary Study-Phylogenetic tree -- Chapter 9: Real Time or Quantitative PCR -- Chapter 10: Tissue or Cell Cultures -- Chapter 11: DNA Micro Array -- Chapter 12: Epigenetics and DNA Methylation -- Chapter 13: RNA sequencing -- Chapter 14: Next Generation sequencing -- Chapter 15: Metagenomics -- Chapter 16: Genome wide association studies (GWAS)/ SNP chips -- Chapter 17: Exome sequencing -- Chapter 18: RNA Interference -- Chapter 19: Expressing cloned genes for protein production, purification and analysis-Biopharming -- Chapter 20: Transgenesis and Biopharming -- Chapter 21: Rapid amplification of cDNA ends (RACE) -- Chapter 22: Gene Therapy -- Chapter 23: Nutrigenomics -- Chapter 24: Gene Editing -- Chapter 25: Introduction to stem cell biology -- Chapter 26: Transcriptomics -- Chapter 27: Development of Biomarker -- Chapter 28: Single cell genomics -- Chapter 29: Big data Analysis.
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  • 16
    In: Springer Nature eBook
    Description / Table of Contents: This reference covers the taxonomy, diversity, bioactivity, and nanotechnology involved in the study of Phoma. It presents the most recent molecular taxonomic approach, secondary metabolites, combating microbial threats and biohazards, and its use in nanotechnology from a basic research to an applied perspective. Expert contributors provide the latest research and applications to present thorough coverage of an important genus in human and plant pathology and bio management. Addresses the key issues in enigmatic taxonomy of the genus Phoma, and provides the current trends in taxonomy Discusses different secondary metabolites, their bioactivities (antifungal, antibacterial, antiviral, antiprotozoal, cytotoxic and herbicidal, etc.) and formulations Presents the role of different Phoma spp. in nanobiotechnology for synthesis of nanoparticles Provides the fossil-based evolutionary trends in Phoma spp.
    Type of Medium: Online Resource
    Pages: XVII, 342 p. 62 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030812188
    Language: English
    Note: Part 1-General Identity and Taxonomy -- Phoma: An Overview -- Phoma Diseases-Identification, Epidemiology and Management -- Taxonomical Evaluation of Phoma-History of Classification, Current Status and Future Directions -- Part 2-Diversity, Diseases and Host Range -- Biodiversity of the Genus Phoma in Different Habitats -- Phoma on Medicinal and Aromatic Plants -- Types of Plant Diseases Caused by Phoma Species and Their Integrated Management -- Plant Pathogenic Phoma Species: Host Range, Symptoms and Distribution -- Overview of Phoma-like Fungi on Legumes: Papilionaceous plants): Pea, Beans, Soybean, Chickpea and Faba Beans -- Vegetable Diseases Caused by Phoma SSP -- Part 3: Phoma Spp. as a Human Pathogen -- Phoma as an Infectious Pathogen in Medical Practice -- Part 4- Bioactivities and Nanotechnology -- Genus Phoma; A Review of Its Potential Bioactivities, Implications and Prospects -- Bioherbicidal Activity of Phoma macrostoma -- Fruitful Decade for Phoma Secondary Metabolites From 2011 to 2020: Chemistry, Chemical Diversity and Biological Activities -- Plant Growth Promoting Phoma spp. -- Biological Management of Plant Diseases by Non-Pathogenic Phoma spp. -- Endophytic Phoma: Potentials and Limitations -- Bioactive Secondary Metabolites of Endophytic Phoma: Biochemistry and Signifigance -- Exploitation of Phoma for Fabrication of Silver Nanoparticles.
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  • 17
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    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.
    Type of Medium: Online Resource
    Pages: XVI, 283 p. 35 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030787998
    Series Statement: Advances in Biochemistry in Health and Disease, 18
    Language: English
    Note: A Protein-centric Perspective of Autophagy and Apoptosis Signaling and Crosstalk in Health and Disease -- Adrenergic receptor signaling pathways in the regulation of apoptosis -- Apoptosis in Ischemic Heart Disease -- Autophagy in cardiac physiology and pathology -- Caspase signaling pathways as convenors of stress adaptation -- Cross talk between apoptosis and autophagy in regulating the progression of heart disease -- Fibroblasts, Fibrosis and Autophagy -- Gene Therapy and Its Application In Cardiac Diseases -- Inflammation and mitochondrial degradation in the heart -- Mitochondria and Cellular Hosts_An Uneasy Truce -- Mitochondrial Dysfunction and Mitophagy -- Proteotoxicity and Autophagy in Neurodegenerative and Cardiovascular Diseases -- Regulation of Cell Death Signaling Pathways in Cardiac Myocytes by Mitochondrial Bnip3 – Inna -- Role of Cardiomyocyte Apoptosis in Heart Failure -- The Role of FGF2 Isoforms In Cell Survival In The Heart.
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  • 18
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.
    Type of Medium: Online Resource
    Pages: XII, 469 p. 106 illus., 83 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071616895
    Series Statement: Methods in Molecular Biology, 2371
    Language: English
    Note: Three Methods for Peptide Cyclization via Lactamization -- Solid-Phase Peptide Cyclization with Two Disulfide Bridges -- Peptide Macrocyclization through Palladium-Catalyzed Late-Stage C-H Activation -- Three Methods for the Solution Phase Synthesis of Cyclic Peptides -- Computational Design of Structured and Functional Peptide Macrocycles -- On-Resin Peptide Cyclization Using the 3-4-Amino-(Methylamino)Benzoic Acid (MeDbz) Linker -- Scalable and Efficient in planta Biosynthesis of Sunflower Trypsin Inhibitor-1 (SFTI) Peptide Therapeutics -- Ligation, Macrocyclization, and Simultaneous Functionalization of Peptides by Multicomponent Reactions (MCR) -- Diels-Alder Cycloadditions for Peptide Macrocycle Formation -- Protein Catalyzed Capture (PCC) Agents for Antigen Targeting -- Preparation of Bacterial Cell-Surface Displayed Semisynthetic Cyclic Peptides -- The Discovery of Peptide Macrocycle Rescuers of Pathogenic Protein Misfolding and Aggregation by Integrating SICLOPPS Technology and Ultra-Throughput Screening in Bacteria -- In Vitro Selection of Thioether-Closed Macrocycle Peptide Ligands by Means of the RaPID System -- MOrPH-PhD: A Phage Display System for the Functional Selection of Genetically Encoded Macrocyclic Peptides -- Discovery of Antimicrobial Peptide Macrocycles Through Bacterial Display -- Assessing the Cellular Uptake, Endosomal Escape, and Cytosolic Entry Efficiencies of Cyclic Peptides -- In silico Analysis of Peptide Macrocycle-Protein Interactions -- Binding Characterization of Cyclic Peptide Ligands to Target Proteins and Chemical Epitopes using ELISA and Fluorescence Polarization Assays -- Determining the Binding Kinetics of Peptide Macrocycles using Bio-Layer Interferometry (BLI) -- Different Approaches to Cyclize a Cell-Penetrating Peptide and to Tether Bioactive Payloads -- Helical Stabilization of Peptide Macrocycles by Stapled Architectures -- Development and Characterization of Light Responsive Peptide Macrocycles -- Hydrogel Formation with Enzyme-Responsive Cyclic Peptides -- Cyclization and Self-Assembly of Cyclic Peptides. .
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  • 19
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    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest techniques used to study the field of tissue engineered vascular grafts (TEVGs). The chapters in this book cover a wide array of topics such as deriving vascular cells from monocytes and induced pluripotent stem cells; engineering vascular grafts using various biomaterials and stem cells, stem cell-derived, or primary vascular cells; biomaterial modification by anticoagulation molecules; vascular bioengineering technologies such as 3D bioprinting; and fabrication of TEVGs with different geometry and multiphase structures. This book also features protocols for grafting and evaluation of vascular grafts in animal models, vascular imaging in animals, and the quantification of blood vessel permeability. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vascular Tissue Engineering: Methods and Protocols is a valuable resource for biomedical engineers, cell biologists, vascular surgeons, doctors, and nurses. .
    Type of Medium: Online Resource
    Pages: XI, 262 p. 79 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071617083
    Series Statement: Methods in Molecular Biology, 2375
    Language: English
    Note: Differentiating Human Pluripotent Stem Cells to Vascular Endothelial Cells for Regenerative Medicine, Tissue Engineering, and Disease Modeling -- Generating Monocyte Derived Endothelial-Like Cells for Vascular Regeneration -- Methods for Differentiating hiPSCs into Vascular Smooth Muscle Cells -- On-Site Differentiation of Human Mesenchymal Stem Cells into Vascular Cells on Extracellular Matrix Scaffold under Mechanical Stimulations for Vascular Tissue Engineering -- End-Point Immobilization of Heparin on Electrospun Polycarbonate-Urethane Vascular Graft -- Microfluidic Co-Axial Bioprinting of Hollow, Standalone, and Perfusable Vascular Conduits -- In Situ Fabrication and Perfusion of Tissue Engineered Blood Vessel Microphysiological System -- Peritoneal Pre-Conditioning Method for In Vivo Vascular Graft Maturation Utilizing a Porous Pouch -- Fabrication of a Completely Biological and Anisotropic Human Mesenchymal Stem Cell-Based Vascular Graft -- Engineering Vascular Grafts with Multiphase Structures -- Fabrication of Small Diameter Tubular Grafts for Vascular Tissue Engineering Applications using Mulberry and Non-Mulberry Silk Proteins -- Fabrication and Evaluation of Tissue-Engineered Vascular Grafts with Hybrid Fibrous Structure -- Controlling Pore Size of Electrospun Vascular Grafts by Electrospraying of Poly(Ethylene Oxide) Microparticles -- Injectable Hydrogels for Vascular Tissue Engineering -- Rabbit Surgery Protocol for End-to-End and End-to-Side Vascular Graft Anastomosis -- Vascular Imaging in Small Animals Using Clinical Ultrasound Scanners -- Vascular Graft Implantation using a Bilateral End-to-Side Aortoiliac Preclinical Model -- Quantification of In Vitro Blood-Brain Barrier Permeability -- Subcellular Force Quantification of Endothelial Cells using Silicone Pillar-Arrays -- Computational Assessment of Hemodynamics Vortices within the Cerebral Vasculature using Information Entropy.
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  • 20
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest techniques and methods used for performing up-to-date glycosylation research. The chapters in this book are organized into four parts. Part One looks at the latest analytical and bioinformatics technologies that enable the characterization of glycosylation complexity. Part Two details the importance of synthetic chemistry and glycoengineering in the fields of bioprocessing and biotherapeutic development. Part Three discusses systems biology and computational technologies used by scientists to analyze glycosylation events in the cell. Part Four focuses on how cellular glycosylation biomarkers can be identified and used to characterize human clinical datasets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Glycosylation: Methods and Protocols is a valuable resource for any scientist or researcher interested in learning more about this exciting and developing field. .
    Type of Medium: Online Resource
    Pages: XI, 325 p. 113 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071616857
    Series Statement: Methods in Molecular Biology, 2370
    Language: English
    Note: Glycoinformatics Tools for Comprehensive Characterization of Glycans Enzymatically Released from Proteins -- GlycoStore: A Platform for H/UPLC and Capillary Electrophoresis Glycan Data -- An Interactive View of Glycosylation -- Characterization and Analysis of Food-Sourced Carbohydrates -- Comparative Glycomics Analysis of Mass Spectrometry Data -- Cell Free Remodeling of Glycosylation of Antibodies -- Rapid Antibody Glycoengineering in CHO Cells via RNA Interference and CGE-LIF N-Glycomics -- In Silico Analysis of Therapeutic Antibody Aggregation and the Influence of Glycosylation -- Recent Advances Towards Engineering Glycoproteins using Modified Yeast Display Platforms -- Computational Modeling of Glycan Processing in the Golgi for Investigating Changes in the Arrangements of Biosynthetic Enzymes -- O-Glycologue: A Formal-Language-Based Generator of O-Glycosylation Networks -- Synthetic Strategies for FRET-Enabled Carbohydrate Active Enzyme Probes -- N-Glycan Characterization by Liquid Chromatography Coupled with Fluorimetry and Mass Spectrometry -- Lectin Histochemistry for Tissues and Cells, and Dual Lectin and Antibody Co-Localization -- Lectin Affinity Chromatography for the Discovery of Novel Cancer Glycobiomarkers: A Case Study with PSA Glycoforms and Prostate Cancer -- Metabolic Labelling of Primary Neurons using Carbohydrate Click-Chemistry -- Monitoring the Sialome on Human Immune Cells.
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  • 21
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    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: This book covers hot topics in the nutrition and metabolism of terrestrial and aquatic animals, including the interorgan transport and utilization of water, minerals, amino acids, glucose, and fructose; the development of alternatives to in-feed antibiotics for animals (e.g., swine and poultry); and metabolic disorders (or diseases) resulting from nutrient deficiencies. It enables readers to understand the crucial roles of nutrients in the nutrition, growth, development, and health of animals. Such knowledge has important implications for humans. Readers will also learn from well-written chapters about the use of new genome-editing biotechnologies to generate animals (e.g., cows and swine) as bioreactors that can produce large amounts of pharmaceutical proteins and other molecules to improve the health and well-being of humans and other animals, as well as the growth and productivity of farm animals. Furthermore, the book provides useful information on the use of animals (e.g., cattle, swine, sheep, chickens, and fish) as models in biomedical research to prevent and treat human diseases, develop infant formulas, and improve the cardiovascular and metabolic health of offspring with prenatal growth restriction. Editor of this book is an internationally recognized expert in nutrition and metabolisms. He has about 40 years of experience with research and teaching at world-class universities in the subject matters. He has published more than 660 papers in peer-reviewed journals, 90 chapters in books, and authored two text/reference books, with a very high H-index of 127 and more than 66,000 citations in Google Scholar. This publication is a useful reference for nutrition and biomedical professionals, as well as undergraduate and graduate students in animal science, aquaculture, zoology, wildlife, veterinary medicine, biology, biochemistry, food science, nutrition, pharmacology, physiology, toxicology, and other related disciplines. In addition, all chapters provide general and specific references to nutrition and metabolism for researchers and practitioners in animal agriculture (including aquaculture), dietitians, animal and human medicines, and for government policy makers.
    Type of Medium: Online Resource
    Pages: VI, 346 p. 43 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030856861
    Series Statement: Advances in Experimental Medicine and Biology, 1354
    Language: English
    Note: Chapter 1: Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health -- Chapter 2: Insights into the Regulation of Implantation and Placentation in Humans, Rodents, Sheep, and Pigs -- Chapter 3: A Role for Fructose Metabolism in Development of Sheep and Pig Conceptuses -- Chapter 4: Nutritional Regulation of Embryonic Survival, Growth and Development -- Chapter 5: Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals -- Chapter 6: Nutritional and Physiological Regulation of Water Transport in the Conceptus -- Chapter 7: Amino Acids in Microbial Metabolism and Function -- Chapter 8: Potential Replacements for Antibiotic Growth Promoters in Poultry: Interactions at the Gut Level and their Impact on Host Immunity -- Chapter 9: Microbiomes in the Intestine of Developing Pigs: Implications for Nutrition and Health -- Chapter 10: L-Arginine Nutrition and Metabolism in Ruminants -- Chapter 11: Hepatic Glucose Metabolism and Its Disorders in Fish -- Chapter 12: Protein-Sourced Feedstuffs for Aquatic Animals -- Chapter 13: Functional Molecules of Intestinal Mucosal Products in Animal Nutrition and Health -- Chapter 14: Use of Genome Editing Techniques to Produce Transgenic Farm Animals -- Chapter 15: Cows as Bioreactors for the Production of Nutritionally and Biomedically Significant Proteins -- Chapter 16: Use of Agriculturally Important Animals as Models in Biomedical Research -- Chapter 17: Pigs (Sus Scrofa) in Biomedical Research.
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  • 22
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    Online Resource
    Singapore : Springer Singapore
    In: Springer Nature eBook
    Description / Table of Contents: This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.
    Type of Medium: Online Resource
    Pages: XI, 234 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811642418
    Language: English
    Note: Chapter 1_Introduction to Bioinformatics -- Chapter 2_Biological databases -- Chapter 3_Sequence Alignment -- Chapter 4_Molecular Evolution -- Chapter 5_Next-generation Sequencing -- Chapter 6_Structural Bioinformatics -- Chapter 7_Systems Biology -- Chapter 8_Statistical Computing in R -- Chapter 9_Clinical Bioinformatics -- Chapter 10_Agricultural Bioinformatics -- Chapter 11_Veterinary Bioinformatics -- Chapter 12_Future trends of Bioinformatics.
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  • 23
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    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: This book shows the importance of rice for human consumption. It focuses on the rice panicle, its morphology and characteristics. High genetic diversity of rice has been economically profitable for mankind; the crop provides food calories to half of the human race on earth and because of its adaptability to diversified and unstable ecological conditions, the plant has an asynchronous flowering system in the panicle. The International Rice Research Institute has a collection of panicles with numerous branching phenotypes and lengths varying from 10 to 43 cm. Due to the heterogeneous architecture, grain filling depends on the position of the spikelet within a panicle. Spikelets on apical branches fertilize early and fill faster compared to their basal counterparts and therefore, individual grain weights of panicle vary widely. The discrepancy in grain filling between spikelets changes with panicle architecture but the relationship of variation in individual grain weight with panicle architecture has not been studied. Spikelet number has increased highly in the newly developed rice cultivars, but it has no benefit accrued on grain filling and yield. This book is recommended for students, researchers and teachers working in this field of expertise.
    Type of Medium: Online Resource
    Pages: XIII, 321 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030678975
    Language: English
    Note: Chapter 1. Importance of rice as human food -- Chapter 2. Botany of rice plant -- Chapter 3. Ontogeny of organ development in rice plant -- Chapter 4. Fertilization and seed development in rice -- Chapter 5. The cellular basis of rice seed growth -- Chapter 6. Genetic analyses of floral development on rice panicle -- Chapter 7. Diversity of panicle architecture and traits influencing grain filling -- Chapter 8. Change of panicle architecture during domestication -- Chapter 9. Physiology of variation in individual grain weight of rice panicle -- Chapter 10. Enzymes controlling starch biosynthesis -- Chapter 11. Hormonal regulation of spikelet development -- Chapter 12. Effects of environmental stresses on physiological factors influencing grainfilling of rice panicle -- Chapter 13. Designer rice in quest of high grain filling.
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  • 24
    In: Springer Nature eBook
    Description / Table of Contents: This open access book offers a cross-sectoral reference for both managers and scientists interested in climate-smart forestry, focusing on mountain regions. It provides a comprehensive analysis on forest issues, facilitating the implementation of climate objectives. This book includes structured summaries of each chapter. Funded by the EU’s Horizon 2020 programme, CLIMO has brought together scientists and experts in continental and regional focus assessments through a cross-sectoral approach, facilitating the implementation of climate objectives. CLIMO has provided scientific analysis on issues including criteria and indicators, growth dynamics, management prescriptions, long-term perspectives, monitoring technologies, economic impacts, and governance tools.
    Type of Medium: Online Resource
    Pages: XXIII, 574 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030807672
    Series Statement: Managing Forest Ecosystems, 40
    Language: English
    Note: Chapter 1. An Introduction to Climate-Smart Forestry in mountain regions -- Chapter 2. Defining climate-smart forestry -- Chapter 3. Assessment of indicators for climate smart management in mountain forests -- Chapter 4. National Forest Inventory data to evaluate Climate-Smart Forestry -- Chapter 5. Efficacy of trans-geographic observational network design for revelation of growth pattern in mountain forests across Europe -- Chapter 6. Changes of tree and stand growth. Review and implications -- Chapter 7. Modelling future growth of mountain forests under changing environments -- Chapter 8. Climate-smart silviculture in mountain regions -- Chapter 9. Smart harvest operations and timber processing for improved forest management -- Chapter 10. Continuous monitoring of tree responses to climate change for smart forestry – a cybernetic web of trees -- Chapter 11. Remote sensing technologies for assessing climate-smart criteria in mountain forests -- Chapter 12. Economic and social perspective of Climate-smart Forestry: incentives for behavioral change to climate-smart practices in the long-term -- Chapter 13. Assessing the economic impacts of climate change on mountain forests: a literature review -- Chapter 14. Review of policy instruments for climate-smart mountain forestry -- Chapter 15. The role of forests in climate change mitigation: the EU context -- Chapter 16. Smartforests Canada – A network of monitoring plots for forest management under environmental change -- Chapter 17. Climate-Smart Forestry in Brazil.
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  • 25
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    In: Springer Nature eBook
    Description / Table of Contents: This book presents the whole picture of the ecological and evolutionary study on the ground beetle group, the subgenus Ohomopterus of the genus Carabus, endemic to Japan. This flightless beetle group consists of many geographic races. They show divergence in key traits for reproductive isolation—body size and genital morphology, which leads to coexistence of two or more species. This beetle group provides an important material to study how a lineage of organisms diversify and form multi-species assemblage, and thereby multiply their species richness. The book introduces novel genomic approaches to resolve questions about evolution of Ohomopterus. The readers will find that this story of evolution in Carabus beetles revealed by recent approaches is much different from what was told in previous literature. Exploring different cases across a wide range of lineages is important in constructing a synthetic theory of species radiation and richness, including speciation and species coexistence. This study on Ohomopterus beetles contributes to the ongoing discussion to understand how and why species multiply and how species richness increases in one area of our planet. Teiji Sota, Professor, Department of Zoology, Graduate School of Science, Kyoto University.
    Type of Medium: Online Resource
    Pages: XIII, 199 p. 101 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811666995
    Series Statement: Entomology Monographs,
    Language: English
    Note: Chapter 1. Introduction to the world of Carabus -- Chapter 2. Ohomopterus: a species radiation with diversification of key traits for mechanical reproductive isolation -- Chapter 3. Biology of Ohomopterus -- Chapter 4. Species assemblages -- Chapter 5. Natural hybridization and reproductive isolation -- Chapter 6. Evolutionary history of Ohomopterus -- Chapter 7. Evolution of a key trait for species diversity: body size -- Chapter 8. Evolution of a key trait for species diversity: genital morphology -- Chapter 9. Overview: How does species richness increase?
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  • 26
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 577 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030890742
    Series Statement: Handbook of Experimental Pharmacology, 271
    Language: English
    Note: From the contents. Preface.-Part I: Molecular aspects of KOR -- Part II: Preclinical research on pharmacology of KOR agonists and antagonists in animals -- Part III: KOR agonists and antagonists in clinical use and in past and present clinical trials.
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  • 27
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    In: Springer Nature eBook
    Description / Table of Contents: This Open Access auto-translation book demonstrates a time series of nutrition improvement in Japan since the introduction of nutrition sciences to Japan about 150 years ago. The chapters present the historical event where nutritional deficiency due to food shortage was improved in almost a century, by the introduction of nutrition policy and practices such as the "Nutrition Improvement Law". The book contributed to the construction of a longevity nation by resolving the double burden of malnutrition, which is a mixture of undernutrition and overnutrition and creating a social environment in which sustainable healthy diets can be accessed. This publication is designed mainly for nutrition specialists, nutritionists, nutrition administrators, medical doctors, pharmacists, nurses, physiotherapists, nutrition educators, cookers, nutrition volunteers, health and nutrition food developers, school lunch managers, and etc. Furthermore, students studying nutrition, teachers involved in the education and training of dietitians, and general consumers who are interested in nutrition, diets, and how to improve malnutrition, will find this book useful. Through this book, dietitians, nutrition volunteers, and consumers engaged in nutrition improvement can understand the significance of nutrition improvement and know specific methods. Young nutritionists who will study and research nutrition can learn the importance of nutrition and take pride in nutrition research. The government official who implements nutrition policy can know the concrete method of nutrition policy. Today, people around the world understand the importance of nutrition and are gaining international interest. However, malnutrition has not improved as much as expected. This book is an interesting way for everyone involved in nutrition to learn how to eradicate malnutrition from the world. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The present version has been revised technically and linguistically by the author in collaboration with Professor Emeritus Dr. Andrew R. Durkin of Indiana University.
    Type of Medium: Online Resource
    Pages: XI, 200 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811663161
    Language: English
    Note: Chapter 1. Preventing and Treating Disease with Nutrition -- Chapter 2. The Birth of Nutrition and the Systematization of Learning -- Chapter 3. History of Nutritional Improvement in Japan -- Chapter 4. Transformation to Human Nutrition -- Chapter 5. Team medicine and multidisciplinary education -- Chapter 6. Safe and appetizing patient meals -- Chapter 7. Nutrition for a 100 year life -- Chapter 8. Nutrition in Japan from an International Perspective -- Chapter 9. Cutting-edge science and technology and personalized nutritional advice -- Chapter 10. A Sustainable healthy diet -- Chapter 11. For those who hope to study health, medical care and welfare -- Chapter 12. Nutrition and diet in the future.
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  • 28
    In: Springer Nature eBook
    Description / Table of Contents: This book discusses the unique interactions of nanoparticles with various biomolecules under different environmental conditions. It describes the consequences of these interactions on other biological aspects like flora and fauna of the niche, cell proliferation, etc. The book provides information about the novel and eco-friendly nanoparticle synthesis methods, such as continuous synthesis of nanoparticles using microbial cells. Additionally, the book discusses nanoparticles' potential impact in different areas of biological sciences like food, medicine, agriculture, and the environment. Due to their advanced physicochemical properties, nanoparticles have revolutionized biomedical and pharmaceutical sciences. Inside the biological milieu, nanoparticles interact with different moieties to adopt stable shape, size, and surface functionalities and form nano-biomolecular complexes. The interaction pattern at the interface form complexes determines the fate of interacting biomolecules and nanoparticles inside the biological system. Understanding the interaction pattern at the nano-bio interface is crucial for the safe use of nanoparticles in natural sciences. This book rightly addresses all questions about the interaction and the ensuing structure and function of these nano-biomolecular complexes. This book caters to students and researchers in the area of biotechnology, microbiology, and pharmaceutical sciences.
    Type of Medium: Online Resource
    Pages: IX, 355 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811625169
    Language: English
    Note: Chapter 1.Impact of isotropic and anisotropic plasmonic metal nanoparticles on healthcare and food-safety management -- Chapter 2. An introduction to different methods of nanoparticles synthesis -- Chapter 3. Classification, Synthesis, and Application of Nanoparticles against Infectious Diseases -- Chapter 4. Nanotechnology in Food Science -- Chapter 5. Facets of Nanotechnology in food processing, packaging and safety: an emerald insight -- Chapter 6. Nanotechnology and its potential application in postharvest technology -- Chapter 7. Nanotechnology mediated detection and control of phytopathogens -- Chapter 8. Nanosystems for Cancer Therapy -- Chapter 9. Phytoplankton mediated nanoparticles for cancer therapy. Chapter 10. Nanotechnology and its potential implications in Ovary Cancer -- Chapter 11. Nanotechnology: An Emerging Field in Protein Aggregation and Cancer Therapeutics -- Chapter 12. Bio-nano interface and its potential application in Alzheimer’s disease -- Chapter 13. Potential of curcumin nanoparticles in tuberculosis management -- Chapter 14. Application of Nanobiosensor in Health care sector -- Chapter 15. Bioactive nanoparticles: A next generation smart nanomaterials for pollution abatement and ecological sustainability -- Chapter 16. Smart nano-materials for bio-imaging applications:An overview -- Chapter 17. Biology of Earthworm in a World of Nano-materials: New Room, Challenges and, Future Perspectives -- Chapter 18. Bioethanol production from agricultural wastes with the aid of nanotechnology -- Chapter 19. Nanotechnology for sustainable bioenergy production.
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  • 29
    Online Resource
    Online Resource
    Singapore : Springer Singapore
    In: Springer Nature eBook
    Description / Table of Contents: This book describes and illustrates 300 species of free-living marine nematodes from the East China Sea and includes eighteen new species. Free-living marine nematode is the most dominant and diverse meiofaunal group in marine benthic habitats. It has strong adaptability and wide distribution, and plays a very important role in the material circulation and energy flow of benthic ecosystem. Up to now, about 7,000 species of free-living marine forms (attached to 2 Class, 8 Order, 86 Family, 662 genera) have been recorded around the world. Some 500 species have so far been reported from the sea areas of China. Among them, more than 300 species were identified from the East China Sea. The book will provide basic data and information of free-living marine nematodes for ecosystem management, protection and utilization of marine biological resources in the East China Sea.
    Type of Medium: Online Resource
    Pages: XIV, 409 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811638367
    Language: English
    Note: Chapter 1. Introduction -- Chapter 2. Morphology of Free-living Nematode -- Chapter 3. Materials and Methods -- Chapter 4. Systematics and taxanomy -- Chapter 5. Order Araeolaimida De Coninck & Schuurmans Stekhoven, 1933 -- Chapter 6. Order Chromadorida Chitwood, 1933 -- Chapter 7. Order Desmodorida De Coninck, 1965 -- Chapter 8. Order Desmoscolecida Filipjev, 1929 -- Chapter 9. Order Monhysterida Filipjev, 1929 -- Chapter 10. Order Plectida Gadea, 1973 -- Chapter 11. Order Enoplida Filipjev, 1929 -- Index to families, genera and species.
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  • 30
    In: Springer Nature eBook
    Description / Table of Contents: This edited book presents the latest research on cucumber, its genetic resources and diversity, tissue culture and genetic transformation, mapping of economic genes and QTLs, whole genome sequencing, comparative genomics, and breeding strategies. The mechanism of sex expression, interspecific hybridization, and cell biology are also described. The book discusses the genome draft of cucumber and the application of genome editing. This book is useful to the students, teachers and scientists in academia and relevant private companies interested in horticulture, genetics, breeding, and related areas.
    Type of Medium: Online Resource
    Pages: XXIII, 199 p. 33 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030886479
    Series Statement: Compendium of Plant Genomes,
    Language: English
    Note: Chapter 1. Importance, Distribution, Botany and Genetics -- Chapter 2. Genome Editing and Its Applications for Improvement -- Chapter 3. The Cucumber Genome – An Update -- Chapter 4. Molecular Mapping of Genes & QTLs for Plant Architecture and Fruit Traits in Cucumber (Cucumis sativus L.) -- Chapter 5. Agrobacterium tumefaciens-Mediated Genetic Transformation in Cucumber -- Chapter 6. QTL Mapping for Abiotic Stress -- Chapter 7. QTL Mapping for Disease Resistance in Cucumber -- Chapter 8. Mapping for Quality Traits -- Chapter 9. Genome Evaluation of Cucumber in Relation to Cucurbit Family -- Chapter 10. Cyto-Molecular Genetics of Interspecific Hybridization in Cucumber -- Chapter 11. Cucumber Sex Expression: Aspects of Gene Interactions -- Chapter 12. Classical Genetics and Traditional Breeding -- Chapter 13. Biotechnological Innovations in Cucumber (Cucumis sativus L.) Development – Current Scenario and Future Perspectives.
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  • 31
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: It has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.
    Type of Medium: Online Resource
    Pages: VII, 329 p. 70 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030913359
    Series Statement: Current Topics in Behavioral Neurosciences, 52
    Language: English
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  • 32
    In: Springer Nature eBook
    Description / Table of Contents: This volume synthesizes and analyzes thirty years of hydrological research in the Danum Valley Conservation Area, a lowland dipterocarp rainforest in Sabah, Malaysia. Ian Douglas explores the role of water in the rainforest ecosystem, setting out the ecological, climatological and geological context of present-day hydrological processes, soil erosion and stream sedimentation. He emphasizes the role of extreme events and natural disturbances in sediment supplies and the evolution of drainage pathways and explains the pathways of rainfall and stream sediment. Douglas then explores the impacts caused by logging, the extreme pulses of sedimentation and the effects of log removal and logging road construction, examining the effects of major storms in the 20 years after tree harvesting. Methods of minimizing logging damage to soils and streams are discussed and the effects on flora and fauns are considered.
    Type of Medium: Online Resource
    Pages: LVI, 362 p. 160 illus., 102 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030915445
    Series Statement: Ecological Studies, Analysis and Synthesis, 242
    Language: English
    Note: Chapter. 1 -- Long-term hydrological research in the humid tropics -- Chapter. 2 -- The forests of the Danum Valley Conservation Area -- Chapter. 3 -- The Danum hydrology project: origins, aims, context -- Chapter. 4 -- The regional physiographical and land management context of the hydrology of Danum Valley -- Chapter. 5 -- Rainfall and its interception by the forest -- Chapter. 6 -- Overland flow -- Chapter. 7 -- Infiltration, soil water and pipeflow -- Chapter. 8 -- Origins of stream flow -- Chapter. 9 -- Sediment supply and movement on slopes -- Chapter. 10 -- Water, sediment and solutes in channels -- Chapter. 11 -- Periodicity of Processes (Impact of extreme events: floods and drought) -- Chapter. 12 -- The lessons from the natural forest -- Chapter. 13 -- The disturbance caused by logging -- Chapter. 14 -- Impact of logging on interception and soil water -- Chapter. 15 -- Changes to erosion rates and sediment yields during and after logging -- Chapter. 16 -- Logging, stream flow, stream chemistry and sediment transport -- Chapter. 17 -- Extreme events and the dynamics of logged catchments -- Chapter. 18 -- Conclusions on the impacts of logging at Danum -- Chapter. 19 -- Mitigating the effects of logging -- Chapter. 20 -- The significance of hydrological and geomorphological processes for lowland tropical rainforest ecology -- Chapter. 21 -- Conclusions from the Long-Term Ecological Research on hydrology at Danum.
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  • 33
    Call number: QD415:009(6)
    Description / Table of Contents: "The primary aim of this revision of Practical Skills in Biomolecular Sciences was to update the text, but we also wished to respond to the helpful comments of several anonymous reviewers of the 5th edition, and in so doing, to reorganise the chapters and include significant new material. The main structural changes we have made are to (1) reorder and rewrite several chapters in the first two sections; (2) add three new chapters on working with bacteria, eukaryotic microbes and viruses; and (3) revise the material on use of software and online sources, to refl ect the greater level of knowledge and experience of today's students. In terms of the text itself, we have sought to use more positive phrasing throughout, to emphasise the active nature of learning in this discipline. Some details of further changes and additions are listed on the back cover. The text references and sources for further study have been updated, while the popular study exercises have been retained"--
    Type of Medium: Book
    Pages: 656 p. : , ill.
    Edition: 6th edition.
    ISBN: 9781292397085
    Language: English
    Location: Library.
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  • 34
    Unknown
    Unknown
    Wiley
    Call number: ordered
    Type of Medium: Unknown
    Edition: 7. Aufl.
    ISBN: 9783527350162
    Location: Library.
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  • 35
    Call number: A240:039
    Description / Table of Contents: "Winners of the Paul Ehrlich Prize The dramatic story of the married scientists who founded BioNTech and developed the first vaccine against COVID-19. Nobody thought it was possible. In mid-January 2020, Ugur Sahin told Özlem Türeci, his wife and decades-long research partner, that a vaccine against what would soon be known as COVID-19 could be developed and safely injected into the arms of millions before the end of the year. His confidence was built upon almost thirty years of research. While working to revolutionize the way that cancerous tumors are treated, the couple had explored a volatile and overlooked molecule called messenger RNA; they believed it could be harnessed to redirect the immune system's forces against any number of diseases. As the founders of BioNTech, they faced widespread skepticism from the scientific community at first; but by the time Sars-Cov-2 was discovered in Wuhan, China, BioNTech was prepared to deploy cutting edge technology and create the world's first clinically approved inoculation for the coronavirus. The Vaccine draws back the curtain on one of the most important medical breakthroughs of our age; it will reveal how Doctors Sahin and Türeci were able to develop twenty vaccine candidates within weeks, convince Big Pharma to support their ambitious project, navigate political interference from the Trump administration and the European Union, and provide more than three billion doses of the Pfizer/BioNTech vaccine to countries around the world in record time. Written by Joe Miller-the Financial Times' Frankfurt correspondent who covered BioNTech's COVID-19 project in real time-with contributions from Sahin and Türeci, as well as interviews with more than sixty scientists, politicians, public health officials, and BioNTech staff, the book covers key events throughout the extraordinary year, as well as exploring the scientific, economic, and personal background of each medical innovation. Crafted to be both completely accessible to the average reader and filled with details that will fascinate seasoned microbiologists, The Vaccine explains the science behind the breakthrough, at a time when public confidence in vaccine safety and efficacy is crucial to bringing an end to this pandemic"--
    Type of Medium: Book
    Pages: 292 p.
    ISBN: ‎ 9781802791242
    Language: English
    Note: The Outbreak -- Project Lightspeed -- The Unknowns -- The mRNA Biohackers -- The Tests -- Forging Alliances -- First in Human -- On Our Own -- It Works! -- The New Normal.
    Location: A240
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  • 36
    Unknown
    Unknown
    Wolters Kluwer Health
    Call number: ordered
    Type of Medium: Unknown
    Edition: 7th ed.
    ISBN: 9781975112608
    Location: Library.
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  • 37
    In: Springer Nature eReference
    Description / Table of Contents: This book was compiled by researchers of Chinese Academy of Forestry, Sichuan Agricultural University, Chinese Academy of Sciences, Southwest Forestry University, and Kunming University of Science and Technology. It has been the most comprehensive monograph about the bamboo resources in China until now. "Illustrated Flora of Bambusoideae in China" is composed of two volumes. Volume 2 consists of 18 chapters corresponding to 18 genera of the tribe Arundinarieae (i.e., Acidosasa, Ampelocalamus, Bashania, Chimonocalamus, Drepanostachyum, Fargesia, Ferrocalamus, Gaoligongshania, Gelidocalamus, Indocalamus, Menstruocalamus, Oligostachyum, Pleioblastus, Pseudosasa, Sasa, Sasaella, Thamnocalamus, Yushania). Sixteen forms, 17 varieties, and 397 species in 18 genera are included in this volume (430 taxa in total).
    Type of Medium: Online Resource
    Pages: 292 illus., 261 illus. in color. eReference. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811627583
    Language: English
    Note: Chimonocalamus -- Drepanostachyum -- Ampelocalamus -- Thamnocalamus -- Fargesia.-Gaoligonshania -- Yushania -- Acidosasa -- Oligostachyum -- Pseudosasa -- Menstruocalamus.-Pleioblastus -- Bashania -- Gelidocalamus -- Sasa -- Sasaella -- Ferrocalamus -- Indocalamus.
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  • 38
    In: Springer Nature eBook
    Description / Table of Contents: This book provides insight into the use of molecular and genomic techniques to the study of populations of critically important species at various geographical scales. It delves into a wide range of issues relevant to biodiversity conservation, such as population differentiation, landscape genomics, ecological interactions, phylogenetics, phylogeography, metagenomics, molecular methods, and data processing. The current rate of biodiversity loss is unprecedented and valuable genetic resources are being lost at an alarmingly rate. Effective strategies to conserve these genetic resources are essential to maintain healthy ecosystems with inter-dependent species. The book is an invaluable resource for training undergraduate and graduate students, postdoctoral fellows, and for young researchers. This book is particularly useful for the policy makers and academics who want to learn about important concepts in population and conservation genetics and genomics.
    Type of Medium: Online Resource
    Pages: XIV, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811660054
    Language: English
    Note: Chapter 1.Phylogenetics and its application in biodiversity conservation -- Chapter 2.Phylogenetics in the Context of Tree Diversity and Conservation -- Chapter 3.Conservation metagenomics: Understanding microbiomes for biodiversity sustenance and conservation -- Chapter 4.Overview of omics-assisted techniques for biodiversity conservation -- Chapter 5. Genetic consequences of fragmentation in tropical forests: Novel approaches to assess and monitor critically endangered species -- Chapter 6.Molecular markers in assessing genetic clonal fidelity for in vitro propagated endangered medicinal plants -- Chapter 7.Strategies, opportunities and challenges in crop genetic diversity conservation: a plant breeder’s perspective -- Chapter 8.Soil Microbial Metagenomics in Agroforestry System: Tools and Techniques -- Chapter 9.Phylogenetic and population genetic studies of Citrus genetic resources in northeast India: a review -- Chapter 10.Next-Generation Amplicon Sequencing: a cost-effective method for exploring microbial biodiversity -- Chapter 11.Molecular characterization and phylogeny of Clerodendrum species occurring in North Eastern Region of India by Internal Transcribed Spacer 2 of Nuclear DNA -- Chapter 12.Population genetic diversity of Dysoxylum binectariferum, an economically important tree species of the Western Ghats, India -- Chapter 13.Gut metagenomics of Pati hanh (Anas platyrhynchosdomesticus) -- Chapter 14.Morphological and molecular characterization of genome types in wild and cultivated bananas (Musa species) of two states in North Eastern India -- Chapter 15.Pollen digital image mapping and its symmetrical correlation using MATLAB -- Chapter 16.Role of Next-generation sequencing (NGS) in understanding the Microbial Diversity.
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  • 39
    In: Springer Nature eBook
    Description / Table of Contents: Mycology has an integral role to play in the development of the biotechnology and biomedical sectors. It has become a subject of increasing importance as new fungi and their associated biomolecules are identified. As this discipline comes to the forefront of research in these sectors, the requirement for a consolidation of available research approaches is required. The First Edition of this book has a few basic and applied protocols. With the Second Edition, this book provides consolidated information on recent developments and the most widely used mycological methods available in the fields of biochemistry, biotechnology and microbiology. The methods outlined offer clear and concise directions to the reader and covers both standard protocols and more applied mycological methods. This book provides useful information for undergraduates, post-graduates, and specialists and researchers studying fungal biology.
    Type of Medium: Online Resource
    Pages: VI, 261 p. 24 illus., 15 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030837495
    Series Statement: Fungal Biology,
    Language: English
    Note: Preface -- Long Term Preservation of Fungal Cultures in All-Russian Collection of Microorganisms (VKM): Protocols and Results -- Confocal Laser and Epifluorescence Microscopy -- Diagnose of Chytid Parasites of Algae in The Plankton -- Sabouraud Agar for Fungal Growth -- FISH, Fluorescence in Situ Hybridization of Uncultured Zoosporic Fungi -- Real-time Quantitative PCR Assay for Counting Uncultured Zoosporic Fungi -- Real-Time PCR Assay in Fungi -- Rapid Identification and Detection of Pathogenic Fungi by Padlock Probes -- Extraction and Characterization of Taxol: An Anticancer Drug from an Endophytic And Pathogenic Fungi -- Recent Advances in Applications of Machine Learning in Fungal Biology -- Fungal Conservation -- TBD -- Loop-Mediated Isothermal Amplification of the Entomopathogenic Fungi, Beauveria bassiana -- Molecular Taxonomy and Multi-Gene Phylogeny of Fungi -- Yeast Isolation Methods from Specialized Habitats -- Assays for the Quantification of Antioxidant Enzymes in Fungi -- Index.
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  • 40
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 332 p. 64 illus., 53 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071617328
    Series Statement: Methods in Molecular Biology, 2378
    Language: English
    Note: Measuring cysteine exposure in unfolded proteins with tetraphenylethene maleimide and its analogues -- Fluorescence-based biosensors for the detection of the unfolded protein response -- Indirect methods to measure unfolded proteins in living cells using fluorescent proteins -- A platform technology for monitoring the Unfolded Protein Response -- The use of fluorescent protein fusions to monitor the unfolded protein response and protein foldase-substrate interactions in plant protoplasts -- High-throughput analysis of protein turnover with tandem fluorescent protein timers -- Detection of HAC1 mRNA Splicing by RT-PCR in Saccharomyces cerevisiae -- Determination of protein translation during the activation of the UPR -- Determination of the stability and intracellular (intra-nuclear) targeting and recruitment of pre-HAC1 mRNA in the Saccharomyces cerevisiae during the activation of UPR -- Assays to study IRE1 activation and signaling -- Analysis of XBP1 contribution to hyperosmolarity-induced lipid synthesis -- Integrating an ER stress reporter for monitoring genome wide UPR-ER in budding yeast -- Analyze mouse knockout models of UPR pathway elements -- In vitro stimulation of IRE1a/XBP1-deficient B cells with LPS -- Detection of PERK signaling in the central nervous system -- Methods to study the mitochondrial unfolded protein response (UPRmt) in Caenorhabditis elegans -- Drosophila Unfolded Protein Response (UPR) assays in vitro and in vivo -- Protein preparation for proteomic analysis of the unfolded protein response in Arabidopsis thaliana -- Structure-based drug discovery of IRE1 modulators -- Chemical screening to detect ER stress regulators.
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  • 41
    In: Springer Nature eBook
    Description / Table of Contents: This book details the development of methods and models to study the HIV-1 viral reservoir with the ultimate goal of achieving a functional cure of HIV infection. Chapters are divided into six parts covering cell lines, in vitro and ex vivo primary cell models of persistent infection, in vitro and ex vivo tissue-derived models, infected animal models human immune cells, methods of detection and analysis of the reservoir, and current approaches to achieve either a functional cure or cART-free long-term remission. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, HIV Reservoirs: Methods and Protocols provides a comprehensive, updated collection of state-of-art methodologies and models to tackle the HIV-1 viral reservoir.
    Type of Medium: Online Resource
    Pages: XIV, 451 p. 61 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071618714
    Series Statement: Methods in Molecular Biology, 2407
    Language: English
    Note: Jurkat-derived (J-Lat, J1.1 and Jurkat E4) and CEM-derived T cell lines (8E5, ACH-2) as Models of Reversible Proviral Latency -- U1 and OM10.1. Myeloid Cell Lines as Surrogate Models Of Reversible Proviral Latency -- An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latencyin primary human CD4+ T cells -- The cultured TCM model of HIV latency -- A Reliable Primary Cell Model for HIV latency: The QUECEL (Quiescent Effector Cell Latency) Method -- TGF-b signaling supports HIV latency in a Memory CD4+ T cell based in vitro model.p Flow Cytometry Sorting of Memory CCR6+CD4+ T-Cells for HIV Reservoirs Quantification -- Human monocyte-derived macrophages (MDM) - Model 1 (GM-CSF) -- Human monocyte-derived macrophages (MDM) - Model 2 -- Modeling HIV latency in astrocytes with the human neural progenitor cell line HNSC.100 -- Hematopoietic stem and progenitor cells (HSPCs) -- HIV reservoirs: Modeling, Quantification and Approaches to a Cure -- More than a gender issue: Testis as a distinctive HIV reservoir and its implication for viral eradication -- Experimental Models to Study HIV Latency Reversal from Male Genital Myeloid Cells -- Decidua basalis: An ex vivo Model to Study HIV-1 Infection during Pregnancy and Beyond -- HIV Reservoirs: Modeling, Quantification, and Approaches to a Cure -- Human Hematopoietic Stem Cell (HSC)-Engrafted NSG Mice for HIV Latency Research -- Inducing long-term HIV-1 latency in the TKO-BLT mouse model -- In situ multiplexing to identify, quantify, and phenotype the HIV-1/SIV reservoir within lymphoid tissue -- Single-cell multiparametric analysis of rare HIV-infected cells identified by duplexed RNAflow-FISH -- Ex vivo differentiation of resting CD4+ T lymphocytes enhances detection of replication competent HIV-1 in viral outgrowth assays -- Quantitative Viral Outgrowth Assay to Measure the functional SIV Reservoir in Myeloid Cells -- Near-full-length single-genome HIV-1 DNA sequencing -- TILDA: Tat/rev Induced Limiting Dilution Assay -- Latency Reversal and Clearance of Persistent HIV Infection -- Cure and long-term remission strategies -- Pathways Toward a Functional HIV-1 Cure: Balancing Promise and Perils for CRISPR Therapy. .
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    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume explores perspectives and methods using cell-free expression (CFE) to enable next-generation synthetic biology applications. The first section focuses on tools for CFE systems, including a primer on DNA handling and reproducibility, as well as methods for cell extract preparation from diverse organisms and enabling high-throughput cell-free experimentation. The second section provides an array of applications for CFE systems, such as metabolic engineering, membrane-based and encapsulated CFE, cell-free sensing and detection, and educational kits. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cell‐Free Gene Expression: Methods and Protocols serves as an ideal guide for researchers seeking technical methods to current aspects of CFE and related applications.
    Type of Medium: Online Resource
    Pages: XV, 435 p. 80 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071619988
    Series Statement: Methods in Molecular Biology, 2433
    Language: English
    Note: Best Practices for DNA Template Preparation towards Improved Reproducibility in Cell-Free Protein Production -- Simple Extract Preparation Methods for E. coli-Based Cell-Free Expression -- Preparation and Screening of Cell-Free Extract from Non-Growing Escherichia coli A19 Cells -- Cell-Free Protein Synthesis Using Pichia pastoris -- A Streptomyces-Based Cell-Free Protein Synthesis System for High-Level Protein Expression -- In Vitro Reconstitution Platforms of Mammalian Cell-Free Expressed Membrane Proteins -- High-Throughput Experimentation Using Cell-Free Protein Synthesis Systems -- Cell-Free Gene Expression from DNA Brushes -- Efficient and Precise Protein Synthesis in a Cell-Free System Using a Set of In Vitro Transcribed tRNAs with Nucleotide Modifications -- Measurement of Transcription, Translation, and Other Enzymatic Processes during Cell-Free Expression Using PERSIA -- Cell-Free Noncanonical Redox Cofactor Systems -- Cell-Free Protein Synthesis for High-Throughput Biosynthetic Pathway Prototyping -- Metabolomics Analysis of Cell-Free Expression Systems Using Gas Chromatography-Mass Spectrometry -- Liposome Preparation by 3D-Printed Microcapillary-Based Apparatus -- Microfluidic Production of Porous Polymer Cell-Mimics Capable of Gene Expression -- Cell-Free Membrane Protein Expression into Hybrid Lipid/Polymer Vesicles -- Cell-Free Synthesis Strategies to Probe Co-Translational Folding of Proteins within Lipid Membranes -- Assembly of RNA Nanostructures from Double Crossover Tiles -- Cell-Free Biosensors and AI Integration -- ROSALIND: Rapid Detection of Chemical Contaminants with In Vitro Transcription Factor-Based Biosensors -- Optical Sensing in Cell-Free Expression -- Cell-Free Paper-Based Analysis of Gut Microbiota and Host Biomarkers -- Detection of Norovirus Using Paper-Based Cell-Free Systems -- A TXTL-Based Assay to Rapidly Identify PAMs for CRISPR-Cas Systems with Multi-Protein Effector Complexes -- Implementing Hands-On Molecular and Synthetic Biology Education Using Cell-Free Technology.
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  • 43
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides methods and techniques to further the study of cancer immunoprevention. Chapters describe tumor-associated antigens, cancer immune-preventive vaccines, generation of TILs, development of monoclonal antibodies, immunoprofiling technologies, tissue multispectral imaging techniques, mass cytometry on suspensions, mutiparametric flow cytometry, genomic expression analysis, and proteomic profiling of tumor microenvironment cell populations and metabolic assessment through novel imaging technologies. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Cancer Immunoprevention: Methods and Protocol aims to further understanding, development of interventional active strategies, and immune-interception of cancer.
    Type of Medium: Online Resource
    Pages: XI, 227 p. 37 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071620144
    Series Statement: Methods in Molecular Biology, 2435
    Language: English
    Note: Cancer Immunoprevention: General Concepts -- Targets and Strategies for Cancer Immunoprevention -- Discovery of targets for cancer immunoprevention -- Antigen pulsed exosome vaccines for Immunoprevention -- Isolation and Maintenance of Tumor-Infiltrating Lymphocytes for Translational & Clinical applications: established methods and new developments -- Monoclonal Antibodies Generation: Updates and Protocols on Hybridoma Technology -- Transcriptomic-Assisted Immune and Neoantigen Profiling in Premalignancy -- Assessment of the Murine Tumor Microenvironment by Multiplex Immunofluorescence -- Cytometry of Mass for Murine Immunoprofiling -- Interrogating the tumor microenvironment by deep tissue immunoprofiling -- Proteomic profiling of the tumor microenvironment -- Metabolic Imaging using Hyperpolarization for Assessment of Premalignancy -- Murine models for lineage tracing cancer initiating cells -- Murine Model of Obesity-Induced Cancer.
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  • 44
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    In: Springer Nature eBook
    Description / Table of Contents: This book presents the cellular wireless network standard NB-IoT (Narrow Band-Internet of Things), which addresses many key requirements of the IoT. NB-IoT is a topic that is inspiring the industry to create new business cases and associated products. The author first introduces the technology and typical IoT use cases. He then explains NB-IoT extended network coverage and outstanding power saving features which are enabling the design of IoT devices (e.g. sensors) to work everywhere and for more than 10 years, in a maintenance-free way. The book explains to industrial users how to utilize NB-IoT features for their own IoT projects. Other system ingredients (e.g. IoT cloud services) and embedded security aspects are covered as well. The author takes an in-depth look at NB-IoT from an application engineering point of view, focusing on IoT device design. The target audience is technical-minded IoT project owners and system design engineers who are planning to develop an IoT application.
    Type of Medium: Online Resource
    Pages: XIII, 122 p. 59 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030849733
    Series Statement: Springer Protocols
    Language: English
    Note: Introduction -- NB-IoT technology overview and deployment status -- Target Applications -- Internet connectivity and protocols -- Device management and cloud support -- Security aspects -- Components, building blocks, IoT device reference design (schematics) -- Conclusion.
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  • 45
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume explores practical procedures on the identification and quantification of pesticides in a variety of samples. Chapters guide the reader through methods and protocols for the extraction of pesticides from biological and non-biological samples, pitfalls in dosing techniques and structures identification, and also provide an overview of the problems that these pesticides cause in human populations. As part of the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of reagents and materials, step-by-step guides and reproducible lab protocols, as well as valuable tips on addressing common problems and avoiding known pitfalls. Authoritative and practical, Pesticide Toxicology is an ideal reference for academia, analysts, toxicologists, environmentalists, and health and industry professionals aiming to understand the associated risks and to limit the use of these substances and minimize their potential damage to human health and the environment.
    Type of Medium: Online Resource
    Pages: IX, 196 p. 40 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071619285
    Series Statement: Methods in Pharmacology and Toxicology,
    Language: English
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  • 46
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest methods used by researchers to study the detection, characterization, and various aspects of viroids. The chapters in this book are organized into seven parts and cover topics such as detection methods based on the biology of viroids; detection techniques based on electrophoresis and hybridization techniques; PCR-based techniques that provide high degrees of sensitivity; emerging area of nucleic acid sequence-based technology; and emerging techniques in viroid research such as RNA silencing, splicing, and viroid structure. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Viroids: Methods and Protocols is a valuable resource for researchers and graduate students who are working with viroid diseases. .
    Type of Medium: Online Resource
    Pages: XIII, 375 p. 81 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071614648
    Series Statement: Methods in Molecular Biology, 2316
    Language: English
    Note: Study and Detection of Citrus Viroids in Woody Hosts -- Detection and Characterization of Viroids via Biological Assays on Herbaceous Hosts -- Analysis on RNA Motif-Based RNA Trafficking in Plants -- Isolation and Transfection of Citrus Protoplasts with Citrus Exocortis -- High-Throughput RNA Extraction from Citrus Tissues for the Detection of Viroids -- Extraction and Purification of Viroids from Herbaceous Hosts -- Detection of Viroids by sPAGE Gel Electrophoresis -- Two-Dimensional Polyacrylamide-Gel Electrophoresis Analysis of Viroid RNAs -- A Simplified Dot-Blot Hybridization Protocol for Potato spindle tuber viroid Detection in Solanaceae -- Gel Blot Hybridization for Viroids -- Tissue Print Hybridization for Detection and Characterization of Viroids -- Fluorescein-Based Electrophoretic Mobility Shift Assay -- Detection of Viroids by RT-PCR -- Detection of Viroids using RT-qPCR -- Multiplex RT-PCR -- Real-Time Detection of Viroids using Singleplex and Multiplex Quantitative Polymerase Chain Reaction -- Reverse Transcription-Loop Mediated Isothermal AMPlification (RT-LAMP) at the Service of Viroid Detection -- SYBR ® Green RT-qPCR for the Universal Detection of Citrus Viroids -- Detection of Avocado sunblotch and Other Viroids using RNA Filter Paper Capture and RT-PCR -- Cloning and Sequencing of Viroids -- QuantiGene Plex Assay: A Method for High-Throughput Multiplex Citrus Viroid Detection and Identification -- Culture-Independent Discovery of Viroids by Deep Sequencing and Computational Algorithms -- An In Silico Detection of a Citrus Viroid from Raw High Throughput Sequencing Data -- Detection of Viroid RNA and vd-siRNA in N. benthamiana Plants: Northern Blot Analyses for Viroid and vd-siRNAs -- Production of Recombinant RNA in Escherichia coli Using Eggplant Latent Viroid as a Scaffold -- Predicting the Structure of a Viroid.
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  • 47
    Online Resource
    Online Resource
    New York, NY : Springer US
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides comprehensive protocols on experimental and computational methods that are used to study probe protein folding reactions and mechanisms. Chapters divided into five parts detail protein engineering, protein chemistry, experimental approaches to investigate the thermodynamics and kinetics of protein folding transitions, probe protein folding at the single molecule, analysis and interpretation of computer simulations, procedures and tools for the prediction of protein folding properties. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Folding: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
    Type of Medium: Online Resource
    Pages: XI, 419 p. 156 illus., 78 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071617168
    Series Statement: Methods in Molecular Biology, 2376
    Language: English
    Note: Mutational Analysis of Protein Folding Transition States: Phi-values -- Engineered Metal-Binding Sites to Probe Protein Folding Transition States: Psi Analysis -- Site-Specific Interrogation of Protein Structure and Stability -- Purification and Handling of the Chaperonin GroEL -- ­Folding free energy surfaces from Differential Scanning Calorimetry -- Fast Folding Kinetics using Nanosecond Laser-Induced Temperature Jump Methods7. Measurement of Submillisecond Protein Folding using Trp Fluorescence and Photochemical Oxidation -- Native State Hydrogen Exchange-Mass Spectrometry Methods to Probe Protein Folding and Unfolding -- Multi-Probe Equilibrium Analysis of Gradual (Un)Folding Processes -- Nmr Analysis Of Protein Folding Interaction Networks -- NMR Relaxation Dispersion Methods for the Structural and Dynamic Analysis of Quickly Interconverting, Low-Populated Conformational Sub-States -- Native State Hydrogen Exchange-Mass Spectrometry Methods to Probe Protein Folding and Unfolding -- Single-Molecule Fluorescence Spectroscopy Approaches for Probing Fast Biomolecular Dynamics and Interactions -- Theory and Analysis of Single-Molecule FRET experiments -- Mechanochemical Evolution Of Disulfide Bonds In Proteins -- Coarse-Grained Simulations of Protein Folding: Bridging Theory and Experiments -- Analysis of Molecular Dynamics Simulations of Protein Folding -- Atomistic Simulations of Thermal Unfolding -- Molecular Simulations of Intrinsically Disordered Proteins and their Binding Mechanisms -- Prediction of Folding and Unfolding Rates of Proteins with Simple Models -- Predicting and Simulating Mutational Effects on Protein Folding Kinetics -- Localization of Energetic Frustration in Proteins -- Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field.
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  • 48
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides detailed technical protocols on current biosensors and imaging technologies and Chapters focus on optical, electrochemical, Quartz crystal microbalance (QCM) biosensors and on medical imaging technologies such as tomography, MRI, and NMR. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Biomedical Engineering Technologies, Volume 1 provides technical details in descriptions of major technologies by experts in the field.
    Type of Medium: Online Resource
    Pages: XXIII, 923 p. 386 illus., 328 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071618035
    Series Statement: Methods in Molecular Biology, 2393
    Language: English
    Note: 1. A Compact Surface Plasmon Resonance Biosensor for Sensitive Detection of Exosomal Proteins for Cancer -- Electrochemistry Coupling Localized Surface Plasmon Resonance for Biochemical Detection -- Preparation of surface plasmon resonance aptasensor for human activated protein C sensing -- Large-scale nanogrooved photonic crystals for label-free biosensing by guided-mode resonance -- Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing -- Ultrasensitive Label-Free Nucleic-Acid Biosensors Based on Bimodal Waveguide Interferometers -- Azimuthal Beam Scanning Microscope Design and Implementation for Axial Localization with Scanning Angle Interference Microscopy -- Computational Optics for Point-of-Care Breast Cancer Profiling -- DNA genotyping based on isothermal amplification and colorimetric detection by consumer electronics devices -- Evaluation of tumor development using hemoglobin saturation profile on rodent dorsal window chamber -- Automated multidimensional nanoscale chromatography for ultra-sensitive targeted mass spectrometry -- Clinical Translation of Stimulated Raman Histology -- Ex vivo and in vitro methods for detection of bioactive staphylococcal enterotoxins -- An Ultracompact Real-time Fluorescence Loop-mediated Isothermal Amplification (LAMP) Analyzer -- Digital Quantification of Human Viral RNA and DNA using a Self-Digitization Chip -- Sample-to-Answer Microfluidic Nucleic Acid Testing (NAT) (file #on Lab-on-a-Disc for Malaria Detection at Point-of-Need -- Charge sensitive optical detection for measurement of small molecule binding kinetics -- Mobile Elisa With A Transparent Incubator -- Smartphone Enabled Point-of-Care Detection of Serum Biomarkers -- Micromachined Optical Fiber Sensors for Biomedical Applications -- Optical and electrochemical aptasensors for sensitive detection of aflatoxin B1 and aflatoxin M1 in blood serum, grape juice and milk samples -- DNA Generated Electric Current Biosensor for Epidermal Growth Factor Receptor 2 (HER2) Analysis -- Agar-Integrated Three-Dimensional Microelectrodes for On-Chip Impedimetric Monitoring of Bacterial Viability -- Quantitative and selective DNA detection with portable personal glucose meter using loop-based DNA competitive hybridization strategy -- Electrochemical aptamer-based sensors: a platform approach to high frequency molecular monitoring in situ in the living body -- Smartphone-based Electrochemical System for Biosensors and Biodetection -- Preparation of notch-4 receptor containing quartz crystal microbalance biosensor for MDA MB 231 cancer cell detection.-The study of the skin cells viscoelastic changes using QCM-D measurements -- Hyperpolarized micro-NMR platform for sensitive analysis of in vitro metabolic flux in living cells -- Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data -- Rapid In Vivo Quantification of Creatine Kinase Activity by Phosphorous-31 Magnetic Resonance Spectroscopic Fingerprinting (31P-MRSF) -- Nanoparticle assisted nuclear relaxation-based detection of oligonucleotides -- Imaging Biomarker Development for Lower Back Pain using Machine Learning -- Acoustic Angiography: Superharmonic Contrast-Enhanced Ultrasound Imaging for Non-Invasive Visualization of Microvasculature -- Patch Clamp Technology for Focused Ultrasonic (FUS) (file #Neuromodulation -- Wireless Wearable Ultrasound Sensor to Characterize Respiratory Behavior -- Forming large effective ultrasound arrays using the swept synthetic aperture technique -- Quantitative bioluminescence tomography for in vivo volumetric-guided radiotherapy -- Evaluation of pulmonary structure and function in patients with cystic fibrosis from electrical impedance tomography data -- In-Vivo Quantitative Whole-Body Perfusion Imaging Using Radiolabeled Copper(II) (file #bis(thiosemicarbazone) (file #Complexes and Positron Emission Tomography (PET) -- Biodegradable AuNP-based plasmonic nanogels as contrast agents for computed tomography and photoacoustics -- Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis -- Economical production of radiopharmaceuticals for preclinical imaging using microdroplet radiochemistry -- Preparation of radiolabeled antibodies for nuclear medicine applications in immuno-oncology -- A Wireless Fully-Passive Acquisition of Biopotentials -- Fabrication of Skin-Mountable Flexible Sensor Patch for Monitoring of Swallowing Function -- The Intelligent Phenotypic Plasticity Platform (IP3) (file #for Precision Medicine-based Injury Prevention in Sport. .
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  • 49