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  • 1
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: Understanding the functional roles of DNA modifications relies on the accurate detection, quantification, and mapping of DNA modifications. Methods for deciphering DNA modifications have substantially improved over the last several years, which greatly revolutionize the field of DNA modifications. In addition to DNA cytosine methylation (5-methylcytosine, 5mC), the best-characterized epigenetic modification, many new modifications have been discovered to present in DNA in recent years. This book provides a comprehensive overview of available techniques and methods together with detailed step-by-step protocols for experimental procedures required to successfully perform analysis on various types of DNA modifications, including 5mC, 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxycytosine (5caC), 5-hydroxymethyluracil (5hmU), 5-formyluracil (5fU), N6-methyladenine (6mA), β-D-glucosyl-5-hydroxymethyluracil (base J) and 8-oxo-7,8-dihydroguanine (OG). This laboratory manual is a valuable source for biochemists and molecular biologists from different fields who wish to investigate DNA modifications.
    Type of Medium: Online Resource
    Pages: VI, 194 p. 48 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9781071612293
    Series Statement: Springer Protocols Handbooks,
    Language: English
    Note: Part 1. Detection of 5mC, 5hmC, 5fC, and 5caC -- Chapter 1. Quantitative assessment of the oxidation products of 5-methylcytosine in DNA by liquid chromatography-tandem mass spectrometry -- Chapter 2. Determination of cytosine modifications in DNA by chemical labeling-mass spectrometry analysis -- Chapter 3. Analysis of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA by capillary electrophoresis-mass spectrometry -- Chapter 4. Simple quantification of epigenetic DNA modifications and DNA damage on multi-well slides -- Chapter 5. Label-free and immobilization-free electrochemical magnetobiosensor for sensitive detection of 5-hydroxymethylcytosine in genomic DNA -- Chapter 6. Electrochemical assay for continuous monitoring of dynamic DNA methylation process -- Chapter 7. Electrogenerated chemiluminescence method for determination of 5‑hydroxymethylcytosine in DNA -- Chapter 8. Quantification of site-specific 5-formylcytosine by integrating peptide nucleic acid-clamped ligation with loop-mediated isothermal amplification -- Chapter 9. Global DNA methylation analysis using methylcytosine dioxygenase -- Part 2. Detection of 6mA -- Chapter 10. Metabolically generated stable isotope for identification of DNA N6-methyladenine origin in cultured mammalian cells -- Chapter 11. Determination of N6‑methyladenine in DNA of mammals and plants by Dpn I digestion combined with size-exclusion ultrafiltration and mass spectrometry analysis -- Part 3. Detection of 5hmU and 5fU -- Chapter 12. Isotope-dilution liquid chromatography-tandem mass spectrometry for detection of 5-hydroxymethyluracil and 5-formyluracil in DNA -- Chapter 13. Detection of 5 Formylcytosine and 5 Formyluracil based on Photo-assisted Domino Reaction -- Chapter 14. Detection of 5-formyluracil and 5-formylcytosine in DNA by fluorescence labelling -- Part 4. Detection of Base J and 8-oxo-7, 8-dihydroguanine -- Chapter 15. Mass spectrometry-based quantification of β-D-glucosyl-5-hydroxymethyluracil in genomic DNA -- Chapter 16. Determination of 8-oxo-7,8-dihydroguanine in DNA at single-base resolution by polymerase-mediated differential coding.
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  • 2
    Call number: ordered
    Type of Medium: Unknown
    Edition: 10. Aufl.
    ISBN: 9783406719783
    Location: Z090
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  • 3
    Type of Medium: Book
    Pages: xvii, 522 p. : , ill.
    Edition: 3rd ed.
    ISBN: 9781975149116
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  • 4
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides an overview about main RNA editing mechanisms, focusing on their functions in physiological as well as pathological conditions. Chapters guide readers through state- of-the art methodologies to investigate RNA editing through wet and dry approaches.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA Editing: Methods and Protocols aims to ensure successful results in the further study of this vital field. .
    Type of Medium: Online Resource
    Pages: XV, 352 p. 47 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071607879
    Series Statement: Methods in Molecular Biology, 2181
    Language: English
    Note: Substitutional RNA Editing in Plant Organelles -- Computational Detection of Plant RNA Editing Events -- Discovering RNA Editing Events in Fungi -- C-to-U RNA Editing: From Computational Detection to Experimental Validation -- Live Cell Quantification of APOBEC1-mediated RNA Editing: A Comparison of RNA Editing Assays -- Adenosine to Inosine RNA Editing Enzyme ADAR and microRNAs -- Quantitative Analysis of Adenosine-to-Inosine RNA Editing -- Discovering A-to-I RNA Editing Through Chemical Methods -- ALU A-to-I RNA Editing - Millions of Sites and Many Open Questions -- RNA Editing in Human and Mouse Tissues -- Bioinformatics Resources for RNA Editing -- High-throughput Sequencing to Detect DNA-RNA Changes -- Detection of A-to-I Hyper-Edited RNA Sequences -- Proteome Diversification by RNA Editing -- MicroRNA Editing Detection and Function: A Combined in silico and Experimental Approach for the Identification and Validation of Putative Oncogenic Targets -- RNA Editing in Interferonopathies -- The Role of RNA Editing in the Immune Response -- RNA Editing in Neurological and Neurodegenerative Disorders -- New Frontiers for Site-directed RNA Editing - Harnessing Endogenous ADARs. .
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  • 5
    In: Springer Nature eBook
    Description / Table of Contents: This book presents a detailed discussion on the direct interactions of plants and microorganisms in the rhizosphere environment. It includes fifteen chapters, each focusing on a specific component of plant-microbe interactions, such as the influence of plants on the root microbiome, and the downstream effects of rhizosphere microbial dynamics on carbon and nutrient fluxes in the surroundings. As such, the book helps readers gain a better understanding of diversity above the ground, and its effect on the microbiome and its functionality.
    Type of Medium: Online Resource
    Pages: XVIII, 356 p. 36 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811561252
    Series Statement: Rhizosphere Biology,
    Language: English
    Note: Bacterial Endophytes: Diversity, Functional Importance, and Potential for Manipulation -- Rhizosphere Carbon Turnover from Cradle to Grave: The Role of Microbe–Plant Interactions -- Root–Soil–Microbe Interactions Mediating Nutrient Fluxes in the Rhizosphere -- Diazotrophic Nitrogen Fixation in the Rhizosphere and Endosphere -- Root Microbiome Structure and Microbial Succession in the Rhizosphere -- Rhizosphere Legacy: Plant Root Interactions with the Soil and Its Biome -- Rhizosphere Microbiome and Soil-Borne Diseases -- Root Disease Impacts on Root-Rhizosphere Microbial Communities -- Newly Introduced or Modified Genes in Plants Potentially Modulate the Host Microbiome -- Rhizosphere Plant–Microbe Interactions Under Abiotic Stress -- Arbuscular Mycorrhizal Fungi Interactions in the Rhizosphere -- Microbial–Faunal Interactions in the Rhizosphere -- Inter-Organismal Signaling in the Rhizosphere -- Molecular Mechanisms of Plant–Microbe Interactions in the Rhizosphere as Targets for Improving Plant Productivity -- Inoculation Effects in the Rhizosphere: Diversity and Function.
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  • 6
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest techniques used to study and understand chromatin reprogramming in embryos and germ cells. Various culture systems are presented, which consist of invaluable tools to investigate many developmental processes. This book also looks at methods for direct examination of DNA, RNA, and proteins in embryos, along with low-input and single-cell assays for exploring these features at the genome-wide scale. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Epigenetics Reprogramming During Mouse Embryogenesis: Methods and Protocols is a valuable resource for any scientist and researcher looking to make new discoveries in this fascinating field of chromatin reprogramming. .
    Type of Medium: Online Resource
    Pages: XI, 318 p. 74 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071609583
    Series Statement: Methods in Molecular Biology, 2214
    Language: English
    Note: Ex Vivo Culture for Preimplantation Mouse Embryo to Analyse Pluripotency -- Microfabricated Device for High Resolution Imaging of Preimplantation Embryos -- In Vitro Culture of Mouse Blastocyst to the Egg Cylinder Stage via Mural Trophectoderm Excision -- Spatially Organized Differentiation of Mouse Pluripotent Stem Cells on Micropatterned Surfaces -- Mouse Primordial Germ Cells: In Vitro Culture and Conversion to Pluripotent Stem Cell Lines -- Generation of Primordial Germ Cell-Like Cells in Small and Large Scales -- Genome-Scale CRISPR Screening for Regulators of Cell Fate Transitions -- Somatic Reprogramming by Nuclear Transfer -- Targeted Transgenic Mice using CRISPR/Cas9 Technology -- Whole-Mount Immunofluorescence Staining of Early Mouse Embryos -- Investigating the Inner Cell Mass of the Mouse Blastocyst by Combined Immunofluorescence Staining and RNA Fluorescent In Situ Hybridization -- Mapping of Chromosome Territories by 3D-Chromosome Painting during Early Mouse Development -- Deciphering the Early Mouse Embryo Transcriptome by Low-Input RNA-seq -- Studying DNA Methylation Genome-Wide by Bisulfite Sequencing from Low Amounts of DNA in Mammals -- Profiling DNA Methylation Genome-Wide in Single Cells -- Tracking Histone Modifications in Embryos and Low Input Samples using Ultrasensitive STAR ChIP-seq -- Chromatin Profiling in Mouse Embryonic Germ Cells by CUT&RUN -- DamID to Map Genome-Protein Interactions in Pre-Implantation Mouse Embryos -- Understanding Chromosome Structure during Early Mouse Development by Single-Cell Hi-C Analysis -- Bioinformatic Analysis of Single Cell Hi-C Data from Early Mouse Embryo.
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  • 7
    In: Springer Nature eBook
    Description / Table of Contents: This volume discusses the vaccine development process and the role delivery concepts contribute to a global goal of effective health outcomes. The chapters in this book cover a wide range of topics such as antigen discovery methods; genetic and protein antigen preparation; preparation of viral vaccines as VLPs; viral and non-viral gene delivery; needle-less or non-invasive delivery technology; vaccine storage; and vaccine administration and assessment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; lists of the necessary materials and reagents; step-by-step, readily reproducible laboratory protocols; and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vaccine Delivery Technology: Methods and Protocols is a valuable resource for both novice and expert researchers, in and outside the field, who would like to gain insight into the impactful field of vaccines. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XV, 590 p. 149 illus., 127 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071607954
    Series Statement: Methods in Molecular Biology, 2183
    Language: English
    Note: Vaccine Delivery and Immune Response Basics -- Isolating Pathogen-Specific Human Monoclonal Antibodies (hmAbs) using Bacterial Whole Cells as Molecular Probes -- Use of Chlamydial Elementary Bodies as probes to Isolate Pathogen-Specific Human Monoclonal Antibodies -- Computational Antigen Discovery for Eukaryotic Pathogens using Vacceed -- Antigen Discovery in Bacterial Pan-Proteomes -- Alphavirus-Based Antigen Preparation -- Production of Chimeric Hepatitis B Virus Surface Antigens in Mammalian Cells -- Bioreactor-Based Antigen Production Process using the Baculovirus Expression Vector System -- High-Throughput Process Development for the Chromatographic Purification of Viral Antigens -- Production of Zika Virus Virus-Like Particles -- Biosynthesis of Glycoconjugate Virus-Like Particles (VLPs) -- Up- and Downstream Processes for Viral Nanoplaxes as Vaccines -- Whole-Cell Vaccine Preparation: Options and Perspectives -- O-Antigen Extraction, Purification, and Chemical Conjugation to a Carrier Protein -- Oligosaccharide Antigen Conjugation to Carrier Proteins to Formulate Glycoconjugate Vaccines -- Exploitation of Capsule Polymerases for the Enzymatic Synthesis of the Polysaccharide Antigens used in Glycoconjugate Vaccines -- Attenuation Methods for Live Vaccines -- Surface Modification of Adenovirus Vector to Improve Immunogenicity and Tropism -- Production of Baculovirus and Stem Cells for Baculovirus-Mediated Gene Transfer into Human Mesenchymal Stem Cells -- Lipofection-Based Delivery of DNA Vaccines -- Flavivirus DNA Vaccine Design and Adjuvant Selection -- Vaccine Delivery with a Detoxified Bacterial Toxin -- Needle-Less or Non-Invasive Delivery Technology -- Lactic Acid Bacteria as Delivery Vehicle for Therapeutics Applications -- A Hybrid Biological-Biomaterial Vector for Antigen Delivery -- Liposomal Dual Delivery of Both Polysaccharide and Protein Antigens -- Thin-Film Freeze-Drying is a Viable Method to Convert Vaccines Containing Aluminum Salts from Liquid to Dry Powder -- The Application of Cryogenic Transmission Electron Microscopy for Evaluation of Vaccine Delivery Carriers -- Methods to Evaluate Immune Cell Recruitment and the Cellular Uptake and Distribution of Antigen following Intramuscular Administration of Vaccine to Mice -- The Quantification of Antigen-Specific T Cells by IFN-γ ELISpot -- The Measurement of Antigen-Specific IgG Titers by Direct ELISA -- Method to Evaluate In Vivo CD8+ T Cell Cytotoxicity in a Murine Model -- Testing Anti-Pneumococcal Antibody Function using Bacteria and Primary Neutrophils -- Viral Infectivity Qunatification and Neutralization Assays using Laser Force Cytology.
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  • 8
    In: Springer Nature eBook
    Description / Table of Contents: This updated book explores a wide repertoire of tools and approaches that have been created, modified, and applied to the study of L. monocytogenes, forming the basis of our understanding of the bacterium today. Many of these key experimental techniques are gathered together herein. The volume presents aspects such as clinical disease and host-pathogen interactions, as well as the study of biofilms which present a significant challenge for control of the organism in the food processing environment. The topics covered in this edition also include sampling in order to isolate Listeria, methods for their identification and characterization, methods for gene manipulation, and methods for control of the organism. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Listeria monocytogenes: Methods and Protocols, Second Edition aims to contribute toward the harmonization of methods used to study this important bacterium, and to be of particular interest to Listeria research both in relation to food association and control as well as clinical microbiology.
    Type of Medium: Online Resource
    Pages: XI, 260 p. 54 illus., 30 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9781071609828
    Series Statement: Methods in Molecular Biology, 2220
    Language: English
    Note: Traditional Methods of Analysis for Listeria monocytogenes -- MALDI-ToF MS: A Rapid Methodology for Identifying and Subtyping Listeria monocytogenes -- Sample Preparation for qPCR Detection of Listeria from Food -- qPCR Validation on the Basis of the Listeria monocytogenes prfA Assay -- Serotype Assignment by Sero-Agglutination, ELISA, and PCR -- Pulsed-Field Gel Electrophoresis (PFGE) Analysis of Listeria monocytogenes -- Multi-Locus Sequence Typing (MLST) and Whole Genome Sequencing (WGS) of Listeria monocytogenes and Listeria innocua -- High-Throughput Characterization of Listeria monocytogenes Using the OmniLog Phenotypic Microarray -- High-Throughput Screening of Biofilm Formation of Listeria monocytogenes on Stainless Steel Coupons Using a 96-Well Plate Format -- Confocal Laser Microscopy Analysis of Listeria monocytogenes Biofilms and Spatially Organized Communities -- Extraction and Preparation of Listeria monocytogenes Subproteomes for Mass Spectrometry Analysis -- Extraction and Analysis of Plasmid DNA from Listeria monocytogenes -- Generation of Nonpolar Deletion Mutants in Listeria monocytogenes Using the “SOEing” Method -- Mutant Construction and Integration Vector-Mediated Genetic Complementation in Listeria monocytogenes -- Internalization Assays for Listeria monocytogenes -- Microscopy of Intracellular Listeria monocytogenes in Epithelial Cells -- Control of Listeria monocytogenes Biofilms in a Simulated Food Processing Environment -- Sampling the Food Processing Environment: Taking up the Cudgel for Preventive Quality Management in Food Processing (FP) -- Isolation and Evaluation of Anti-Listeria Lactococcus lactis from Vegetal Sources.
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  • 9
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This third edition expands upon the previous edition with current, detailed methods on different aspects, and landmarks advancing knowledge on Salmonella research. With new chapters on molecular assays for detection, identification and serotyping of Salmonella, quantitative proteomic identification of host factors involved in salmonella infection, determination of antimicrobial resistance in salmonella, site-directed mutagenesis, chromosomal gene analysis, various microscopy methods to analyze salmonella interaction with host cells, in vitro modeling of gallbladder-associated salmonella colonization, and analysis of salmonella phages and prophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Salmonella: Methods and Protocols, Third Edition aims to provide methods that will have an impacted Salmonella research.
    Type of Medium: Online Resource
    Pages: XI, 210 p. 53 illus., 32 illus. in color. , online resource.
    Edition: 3rd ed. 2021.
    ISBN: 9781071607916
    Series Statement: Methods in Molecular Biology, 2182
    Language: English
    Note: Next day Salmonella spp. Detection Method Based on real-time PCR for Foods -- Isolation of Salmonella spp. from Animal Feed -- Investigating Outbreaks of Salmonella Typhimurium using Case-control Studies, with a Reference to the One Health Approach -- Detection of Salmonella by the 3M Molecular Detection Assays - MDS® Method -- CRISPR-Typing of Salmonella Isolates -- CRISPR Typing of Salmonella Isolates from Different Resources -- Immunomagnetic Separation of Salmonella with Tailored Magnetic Micro and Nanocarriers -- Self-labeling Enzyme Tags for Translocation Analyses of Salmonella Effector Proteins -- Smartphone Based Paper Microfluidic Immunoassay of Salmonella and E. coli -- Correlative Light and Scanning Electron Microscopy to Study Interactions of Salmonella enterica with Polarized Epithelial Cell Monolayers -- Production of Murine Macrophages from Hoxb8-immortalized Myeloblasts: Utility and use in the Context of Salmonella Infection -- In vitro Evaluation of Anti-biofilm Agents Against Salmonella enterica -- Generation of Random luxCDABE Transcripcional Fusions in the Genome of Salmonella enterica -- Vaccine Based On Outer Membrane Vesicles Using Hydrogels as Vaccine Delivery System -- Detection and Characterization of Salmonella enterica Serotypes by Simple PCR Technologies -- Determination of Antimicrobial Resistance of Salmonella in Pork -- Molecular typing of Salmonella by Pulsed-field Gel Electrophoresis -- Isolation and Identification of Salmonella in Pork.
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  • 10
    In: Springer Nature eBook
    Description / Table of Contents: Converting biomass to biofuels involves hydrolyzing cellulose to sugars using cost-intensive commercial enzymes – an expensive step that makes large-scale production economically non-viable. As such, there is a need for low-cost bioprocessing. This book critically evaluates the available bioprocessing technologies for various biofuels, and presents the latest research in the field. It also highlights the recent developments, current challenges and viable alternative approaches to reduce the overall cost of producing biofuels.
    Type of Medium: Online Resource
    Pages: XII, 231 p. 53 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811570704
    Series Statement: Clean Energy Production Technologies,
    Language: English
    Note: Chapter 1. Impact of fermentation types on enzymes used for biofuels production -- Chapter 2. Downstream Processing; Applications and Recent Updates -- Chapter 3. Role of bioreactors in bio-fuel generations -- Chapter 4. Bioprocess for Algal Biofuels Production -- Chapter 5. Effect of Bioprocess Parameters on Biofuel Production -- Chapter 6. Role of substrate to improve biomass to bio fuel production technologies -- Chapter 7. Techno-economic analysis of second-generation bio-fuel technologies -- Chapter 8. Recent advances in metabolic engineering and synthetic biology for microbial production of isoprenoid-based biofuels: an overview -- Chapter 9. Applications of biosensors for metabolic engineering of microorganisms and its impact on biofuel production -- Chapter 10. Recent progress in CRISPR-based technologies applications for biofuels production.
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  • 11
    In: Springer Nature eBook
    Description / Table of Contents: This exciting book presents diverse applications of microalgal renewable resources to meet modern demands for energy and value-added products. It also comprehensively describes the role of algae in sustainable and cost-effective wastewater treatment strategies, and highlights the latest research on, advances in and biotechnological relevance of algae in the areas of bioenergy, bioremediation, pharmaceuticals, nutraceuticals and green economy. The book addresses gaps in the fields of bioenergy, waste management, health and economy by providing broad information on bioenergy production, management strategies, drug development, nutraceuticals products and biobased economy using algae at the commercial level. The book introduces researchers to key and emerging innovations in the field of algal biology research and will assist policymakers, environmentalists, scientists, students and global thinkers in defining sustainable developmental goals for the future. Accordingly, it is an extremely important read for researchers and students in the environmental sciences, life sciences and chemistry, experts in the energy sector and policymakers alike. .
    Type of Medium: Online Resource
    Pages: XI, 373 p. 80 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811575181
    Language: English
    Note: Chapter 1. Valorisation of wastewater via nutrient recovery using algae-based processes -- Chapter 2.Constructed wetland and microalgae: A revolutionary approach of boremediation and sustainable energy production -- Chapter 3. Mitigation of Heavy Metals Utilizing Algae and its Subsequent Utilization for Sustainable fuels -- Chapter 4. Adaptive and tolerance mechanism of microalgae in removal of cadmium from wastewater -- Chapter 5. Algae as miniature waste water scavengers -- Chapter 6. Parametric modeling and optimization of phycoremediation of Cr(VI) using artificial neural network and simulated annealing -- Chapter 7. An insight on potential application of microalgae in pharmaceutical and nutraceutical production -- Chapter 8. The budding potential of algae in cosmetics -- Chapter 9. Food supplements formulated with Spirulina -- Chapter 10. Fucoxanthin Production from Diatoms: Current Advances and Challenges -- Chapter 11. Liquid Biofuels from Algae -- Chapter 12. UV-B coupled lipid induction: A strategies towards economical biofuel production through algae -- Chapter 13. Microalgae Mediated Nanomaterials Synthesis -- Chapter 14. Algae-mediated biological synthesis of metallic nanoparticles and their applications -- Chapter 15. Cyanobacterial blooms and Cyanotoxins: Occurrence and Detection -- Chapter 16. Potential of Golden Brown Algae in Forensic Analysis: A Review. .
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  • 12
  • 13
    In: Springer Nature eBook
    Description / Table of Contents: The existential environmental crisis prompted the United Nations to formulate the Millennium Development Goals at the turn of the 21st century in order to embark on an era of sustainable development. The progress and deficiencies in achieving the Millennium Development Goals provided impetus to the intelligentsia and policymakers to map out the pertinent goals for a sustainable growth trajectory for humanity and the planet. The United Nations’ 2030 Agenda for Sustainable Development, which was adopted in September 2015, took the shape of 17 Sustainable Development Goals (SDGs) and 169 targets. In effect, the 17 Sustainable Development Goals focus on protecting the earth's life support systems for intra- and inter-generational equity and for development that is rooted in sustainability science. Attaining these goals is an uphill task; nevertheless, scientific knowledge, trans and interdisciplinary inquiries, concerted global action and capacity building would provide an enabling environment for achieving the SDGs. This book explores the synergies and trade-offs between climate change management and other SDGs. It highlights the policy imperatives as well as the interrelations between combating climate change and its impacts (SDG 13) and food and nutritional security (SDG 2), water security (SDG 6), soil security (SDG 15), energy security (SDG 7), poverty eradication (SDG 1), gender equality (SDG 5), resilient infrastructure (SDG 9), and sustainable and resilient cities (SDG 11).
    Type of Medium: Online Resource
    Pages: XIV, 402 p. 115 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811573019
    Language: English
    Note: Chapter 1. Achieving Food and Nutrition Security and Climate Change: Clash of the Titans or Alignment of the Stars? -- Chapter 2. Climate Change, Hunger and Food Security in Asia with special reference to Sri Lanka: Can the SDGs be Achieved by 2030? -- Chapter 3. The Status of Climate Variability and Food Accessibility: A Case of Households in Gauteng Province, South Africa -- Chapter 4. Climate resilient mariculture technologies for food and nutritional security -- Chapter 5. Climate change and adaptation: Recommendations for agriculture sector -- Chapter 6. Integrated Farming Systems: Climate Resilient Sustainable Food Production System in the Indian Himalayan Region -- Chapter 7. Adaptation mechanism of methylotrophic bacteria to drought condition and its strategies in mitigating plant stress caused by climate change -- Chapter 8. Synergies and Trade-offs between Climate Change and the Sustainable Development Goals in the Context of Marine Fisheries -- Chapter 9. Increasing Synergies between Climate Change and Sustainable Development in Energy Policy -- Chapter 10. Ensuring Domestic Water Security for Cities under Rapid Urbanisation and Climate Change Risks -- Chapter 11. Improving Water Productivity for Smallholder Rice Farmers in the Upper West Region of Ghana: A Review of Sustainable Approaches -- Chapter 12. Synergies between climate change, biodiversity, ecosystem function and services, indirect drivers of change and human well-being in forests -- Chapter 13. Climate change projections of current and future distributions of the endemic Loris lydekkerianus (Lorinae) in peninsular India -- Chapter 14. Climate Change, Air Pollution and SDG 3: An Indian Perspective -- Chapter 15. Empowerment of fisherwomen through marine farming.
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  • 14
    In: Springer Nature eBook
    Description / Table of Contents: Recent developments in the field of nutrition have led to increased interest in herbs and medicinal plants as phytochemical-rich sources for functional food, nutraceuticals, and drugs. As research sheds light on the therapeutic potential of various bioactive phytochemicals, the demand for plant extracts and oils has increased. Black cumin or black seeds (Nigella sativa) have particularly widespread nutritional and medicinal applications. In traditional medicine, black seeds are used to manage fatigue and chronic headache. Black seed oil is used as an antiseptic and analgesic remedy and for treatment of joint's pain and stiffness and can be mixed with sesame oil to treat dermatosis, abdominal disorders, cough, headache, fever, liver ailments, jaundice, sore eyes, and hemorrhoids. Thymoquinone, the main constituent in black seed volatile oil, has been shown to suppress carcinogenesis. Black cumin (Nigella sativa) seeds: Chemistry, Technology, Functionality, and Applications presents in detail the chemical composition, therapeutic properties, and functionality of high-value oils, phytochemicals, nutrients, and volatiles of the Nigella sativa seed. Organized by formulation (seeds, fixed oil, essential oil, and extracts), chapters break this seed down into its chemical constituents and explore their role in the development of pharmaceuticals, nutraceuticals, novel food, natural drugs, and feed. Following numerous reports on the health-promoting activities of Nigella sativa, this is the first comprehensive presentation of the functional, nutritional, and pharmacological traits of Nigella sativa seeds and seed oil constituents.
    Type of Medium: Online Resource
    Pages: XXII, 558 p. 59 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030487980
    Series Statement: Food Bioactive Ingredients,
    Language: English
    Note: 1.Introduction to black cumin (Nigella sative): Chemistry, Technology, Functionality and Applications -- Section 1. Nigella sative seeds: Cultivation, Composition and Applications -- 2. Effect of cultivation, fertilization and irrigation practices on Nigella sative yield and quality -- 3. Morphological characters of Nigella sativa -- 4. Micro and macroscopic characterization of traded Nigella sativa seeds using applied systematics techniques -- 5. Composition of Nigella sativa seeds -- 6. Nigella sativa seed peptides (Thionins) -- 7. Black cumin polysaccharides -- 8. Thymoquinone: Chemistry and cunctionality -- 9. Novel Prospective of Nigella sativa Essential Oil Analysis, Culinary and Medicinal Uses -- 10. Rediscovering Nigella Seeds Bioactives Chemical Composition using Metabolomics Technologies -- 11. Health promoting activities of Nigella sativa seeds -- 12. Nigella sativa seed extract in green synthesis and nanocomposite -- 13. Food applications of Nigella sative seeds -- 14. Nutraceutical importance and applications of Nigella sativa seed flour -- 15. Nigella sativa seed cake: nutraceutical significance and applications in the food and cosmetic industry -- 16. Nigella sative seeds in cosmetic products -- 17. Nigella sativa supplementation in ruminant diets: production, health, and environmental perspectives -- 18. Nigella sativa seeds and its derivatives in poultry feed -- 19. Nigella sative Seeds and Its Derivatives in Fish Feed -- Section 2: Nigella sative fixed oil: Chemistry, Technology, Functionality and Applications -- 20. Composition and Functionality of Nigella sativa Fixed Oil -- 21. Effect of processing on the composition and quality of Nigella sativa fixed oil -- 22. Food applications of Nigella sativa Fixed Oil -- 23. Health-Promoting Activities of Nigella sativa Fixed Oil -- 24. Micro- and Nano-encapsulation of Nigella sativa Oil -- 25. Biodiesel Production Potential of Nigella sativa Oil -- Section 3: Nigella sative essential oil: Chemistry, Technology, Functionality and Applications -- 26. Composition and functionality of Nigella sativa essential oil -- 27. Effect of processing on the composition and quality of Nigella sativa essential oil -- 28. Food applications of Nigella sativa essential oil -- 29. Health-promoting activities of Nigella sativa essential oil -- Section 4: Nigella sative seed extracts: Chemistry, Technology, Functionality and Applications -- 30. Composition and Functionality of Nigella sativa Seed Extracts -- 31. Nigella sativa seed extracts in functional foods and nutraceutical applications -- 32. Health promoting activities of Nigella sativa seed extracts.
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  • 15
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Thorough and cutting-edge, Nanomedicines for Brain Drug Delivery is a valuable resource that will help researchers guide and advance the field of nanomedicines for the brain and nervous system.
    Type of Medium: Online Resource
    Pages: XII, 280 p. 33 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071608388
    Series Statement: Neuromethods, 157
    Language: English
    Note: Biodegradable Polymeric Nanoparticles for Brain-Targeted Drug Delivery -- Liposomes as Brain Targeted Delivery Systems -- Nanofibres and Nanostructured Scaffolds for Nervous System Lesions -- Self-Assembling Peptide Nanofibrous Scaffolds in Central Nervous System Lesions -- The Use of Peptide and Protein Vectors to Cross the Blood Brain Barrier for the Delivery of Therapeutic Concentration of Biologics -- Inorganic Nanoparticles and Their Strategies to Enhance Brain Drug Delivery -- Magnetic Nanoparticles as Delivery Systems to Penetrate the Blood Brain Barrier -- Nose-to-Brain Drug Delivery Enabled by Nanocarriers -- In Vitro Models of Central Nervous System Barriers for Blood Brain Barrier Permeation Studies -- Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery.
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  • 16
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This second edition provides a comprehensive laboratory manual on skeletal development and skeletal repair research utilizing mouse models. Chapters provide methods and protocols on the most current and cutting-edge techniques in skeletal development and repair, histological, cellular, and molecular techniques. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Skeletal Development and Repair: Methods and Protocols-Second Edition aims to ensure successful results in the further study of this vital field.
    Type of Medium: Online Resource
    Pages: XV, 482 p. 125 illus., 105 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9781071610282
    Series Statement: Methods in Molecular Biology, 2230
    Language: English
    Note: Overview of Skeletal Development -- Overview of Skeletal Repair (Fracture Healing and Its Assessment) -- Advantages and Limitations of Cre Mouse Lines Used in Skeletal Research -- Generation of Closed Transverse Fractures in Small Animals -- A Mouse Femoral Ostectomy Model to Assess Bone Graft Substitutes -- Surgical Induction of Posttraumatic Osteoarthritis in the Mouse -- Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton -- Murine Limb Bud Organ Cultures for Studying Musculoskeletal Development -- Murine Limb Explant Cultures to Assess Cartilage Development -- Renal Capsule Transplantation to Assay Angiogenesis in Skeletal Development and Repair -- MicroCT for Scanning and Analysis of Mouse Bones -- Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties -- Phenotyping Intact Mouse Bones using Bone CLARITY -- Processing and Sectioning Undecalcified Murine Bone Specimens -- Preparation of Thin Frozen Sections from Nonfixed And Undecalcified Hard Tissues Using Kawamoto's Film Method (2020) -- Demineralized Murine Skeletal Histology -- Assessment of Osteocytes: Techniques for Studying Morphological and Molecular Changes Associated With Perilacunar/ Canalicular Remodeling Of the Bone Matrix -- Cell Lineage Tracing: Co-localization of Cell Lineage Markers with a Fluorescent Reporter -- Immunofluorescent Staining of Adult Murine Paraffin-embedded Skeletal Tissue -- Detection of Hypoxic Regions in the Bone Microenvironment -- EdU-based Assay of Cell Proliferation and Stem Cell Quiescence in Skeletal Tissue Sections -- Whole-mount In Situ Hybridization in Murine Tissues -- Bone Marrow Stromal Cell Assays – In Vitro and In Vivo -- Isolation and Culture of Periosteum Derived Progenitor Cells from Mice -- Isolation and Culture of Murine Primary Chondrocytes: Costal and Growth Plate Cartilage -- Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts -- Mitochondrial Function and Metabolism of Cultured Skeletal Cells -- Radiolabeled Amino Acid Uptake Assays in Primary Bone Cells and Bone Explants -- RANKL-based Osteoclastogenic Assay from Murine Bone Marrow Cells -- Hematopoietic Stem Cell Cultures and Assays. .
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  • 17
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides the most current methods to study RNA remodeling proteins. Chapters detail methods, ranging from basic to complex, procedures to identify RNA remodeling proteins and their cofactors, physiological RNA targets and biological functions, and complex molecular mechanisms of action using purified components. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA Remodeling Proteins: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
    Type of Medium: Online Resource
    Pages: XIV, 437 p. 77 illus., 57 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9781071609354
    Series Statement: Methods in Molecular Biology, 2209
    Language: English
    Note: Key Points to Consider when Studying RNA Remodeling by Proteins -- Happy Birthday : 30 Years of RNA Helicases -- Known Inhibitors of RNA Helicases and their Therapeutic Potential -- Identifying RNA Helicase Inhibitors Using Duplex Unwinding Assays -- Thermal Shift Assay for Characterizing the Stability of RNA Helicases and their Interaction with Ligands -- SRCD and FTIR Spectroscopies to Monitor Protein-induced Nucleic Acid Remodeling -- High throughput Protein-Nucleic Acid Interaction Assay Based on Protein Induced Fluorescence Enhancement -- Probing RNA Helicase Conformational Changes by Single-molecule FRET Microscopy -- A Fluorescent Assay to Monitor Ligand-Dependent Closure of the Hexameric Rho Helicase Ring -- A Simple Fluorescence Microplate Assay to Monitor RNA-DNA Hybrid Unwinding by the Bacterial Transcription Termination Factor Rho -- Monitoring Enzymatic RNA G-quadruplex Unwinding Activities by Nuclease Sensitivity and Reverse Transcription Stop Assays -- Using Magnetic Tweezers to Unravel the Mechanism of the G-quadruplex Binding and Unwinding Activities of DHX36 Helicase -- Characterization of the Brr2 RNA Helicase and its Regulation by other Spliceosomal Proteins using Gel-based U4/U6 di-snRNA Binding and Unwinding Assays -- Monitoring Acetylation of the RNA-helicase DDX3X, a Protein Critical for Formation of Stress Granules -- In vivo cross-linking Followed by polyA Enrichment to Identify Yeast mRNA Binding Proteins -- Deciphering the Dynamic Landscape of Transcription-associated mRNP quality Control Components over the Whole Yeast Genome -- Probing the Conformational State of mRNPs using smFISH and SIM -- Probing Transcriptome-wide RNA Structural Changes Dependent on the DEAD-box Helicase Dbp2 -- In situ hybridization – Proximity Ligation Assay (ISH-PLA) to Study the Interaction of HIV-1 RNA and Remodeling Proteins -- RNAi Screening to Identify Factors that Control Circular RNA Localization -- A Cell-Free System for Investigating Human MARF1 Endonuclease Activity -- Monitoring eIF4E-dependent Nuclear 3’ end mRNA Cleavage -- An In Vitro Approach To Study RNase III Activities Of Plant RTL Proteins -- Analysis of Bacillus subtilisRibonuclease Activity In Vivo -- Assay of Bacillus subtilis Ribonuclease Activity in vitro -- Protein Pulldown Assays to Monitor the Composition of the Bacterial RNA Degradosome. .
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  • 18
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides basic and cutting-edge methods and protocols to study the major characteristics of eukaryotic cells. Chapters detail the different pathways of endocytosis in vivo, real time imaging of endocytic steps, endocytosis in model organisms, super-resolution methods to follow proteins involved in exocytosis, specific protocols for exocytosis in specialized cells such as neutrophils or neuroendocrine cells, as well as secretion of exosomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and clearly written, Exocytosis and Endocytosis: Methods and Protocols is a valuable resource for researchers in the fields of cell biology, neurology, immunology, oncology, and those interested in studying protein trafficking and signal regulation.
    Type of Medium: Online Resource
    Pages: XII, 329 p. 84 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071610442
    Series Statement: Methods in Molecular Biology, 2233
    Language: English
    Note: Stoichiometry of Receptors at the Plasma Membrane during Their Endocytosis using Total Internal Reflection Fluorescent (TIRF) Microscopy Live Imaging and Single Molecule Tracking -- Measuring Endocytosis During Proliferative Cell Quiescence -- Measurements of Compensatory Endocytosis by Antibody Internalization and Quantification of Endocytic Vesicle Distribution In Adrenal Chromaffin Cells -- Quantitative Methods to Study Endocytosis and Retrograde Transport of Cargo Proteins -- High-content Drug Discovery Screening of Endocytosis Pathways -- Methods for Monitoring Endocytosis in Astrocytes -- Monitoring Activity-Dependent Bulk Endocytosis in Primary Neuronal Culture Using Large Fluorescent Dextrans -- Quantitative Flow Cytometry-Based Assays for Measuring Constitutive Secretion -- High-throughput Screening for Insulin Secretion Modulators -- Different Approaches to Record Human Sperm Exocytosis -- Bovine Chromaffin Cells: Culture and Fluorescent Assay for Secretion -- Measurement of Exocytosis in Genetically Manipulated Mast Cells -- Super-Resolution Microscopy and Particle Tracking Approaches for the Study of Vesicular Trafficking in Primary Neutrophils -- An Approach to Monitor Exocytosis in White Adipocytes -- Amperometry in Single Cells and Tissue -- Measurements of Exocytosis by Capacitance Recordings and Calcium Uncaging In Mouse Adrenal Chromaffin Cells -- RUSH-synchronized Secretion to Measure Local Exocytosis -- Combining Single Molecule Super-Resolution Imaging Techniques to Unravel the Nanoscale Organization of the Presynapse -- Induction of Ca2+ Dependent Exocytotic Processes by Laser Ablation of Endothelial Cells -- Transmission Electron Microscopy and Tomography on Plasma Membrane Sheets to Study Secretory Docking -- Spatial and Temporal Aspects 0f Exocytosis Studied on the Isolated Plasma Membranes.
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  • 19
    In: Springer Nature eBook
    Description / Table of Contents: This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.
    Type of Medium: Online Resource
    Pages: XIII, 332 p. 20 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030569051
    Language: English
    Note: Section 1: Introduction -- Chapter 1: Introduction: An overview of host-directed therapies for tuberculosis -- Section 2: Targeting immunometabolism -- Chapter 2: Sirtuin deacetylases: Linking Mycobacterial infection and host metabolism -- Chapter 3:The mammalian target of rapamycin complex 1 (mTORC1): an ally of M. tuberculosis in host cells -- Chapter 4: HIF-1α as a potential therapeutic target for tuberculosis treatment -- Chapter 5: Nuclear receptors in host-directed therapies against tuberculosis -- Section 3: Enhancing anti-mycobacterial mechanisms -- Chapter 6: Autophagy as a target for host-directed therapy against tuberculosis -- Chapter 7: Metformin: a leading HDT candidate for TB -- Chapter 8: Statins as host-directed therapy for tuberculosis -- Chapter 9: Antimycobacterial attributes of mitochondria: An insight into host defense mechanisms -- Section 4: Targeting immune cells -- Chapter 10: Conventional and unconventional lymphocytes in immunity against Mycobacterium tuberculosis -- Chapter 11: Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma -- Chapter 12: Targeting suppressor T cells -- Chapter 13: Neutrophil-mediated mechanisms as targets for host-directed therapies against tuberculosis -- Chapter 14: Type I interferon and interleukin-1 driven inflammatory pathways as targets for HDT in tuberculosis -- Chapter 15: Mucosal-associated invariant and Vγ9Vδ2 T cells -- Chapter 16: Airway epithelial cells.-Section 5: Preclinical models for assessing HDTs -- Chapter 17: In vitro models of human granuloma formation to analyze host-directed therapies -- Chapter 18: C3HeB/FeJ as a key mouse strain for testing host-directed therapies against tuberculosis -- Chapter 19: The Rabbit Model for Assessing Host-Directed Therapies for Tuberculosis -- Section 6: Clinical trials of HDTs and special considerations for study endpoints -- Chapter 20:Clinical trials of TB-HDT candidates -- Chapter 21:Outcomes for clinical trials of host-directed therapies for tuberculosis -- Chapter 22: Pharmacological considerations for clinical trials of host-directed therapies for tuberculosis.
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  • 20
    In: Springer Nature eBook
    Description / Table of Contents: An increasing population has put tremendous pressure on agricultural productivity to fulfill the demands of human consumption. Numerous agricultural activities and techniques have been developed to raise annual crop production globally. While agriculture has succeeded in enhancing the yearly crop productivity, this achievement is at the cost of environmental degradation by applying synthetic persistent substances, such as industrial fertilizers, pesticides, herbicides, etc. Chemical fertilizers are nearly as destructive as they are productive, causing monocultures and consequences associated with elimination of diversity, nutrient pollution as evidenced by algae blooms, eutrophication, water quality issues, lower oxygen levels and dangers to fish stocks. Therefore, the scientific approach to maintain sustainable fertility in soil and plants is to switch over to biofertilisers. Biofertilisers are compounds of organic matter that are applied to crops for growth and health. Their constituent micro-organisms interact in an ecofriendly manner with the soil, root and seeds of plants, promoting the growth of micro-flora that enhances soil fertility. They are known to play a number of vital roles in soil fertility, crop productivity and production in agriculture. Application of biofertilisers results in increased mineral and water uptake, root development, vegetative growth and nitrogen fixation. They liberate growth promoting substances and vitamins and help to maintain soil fertility. They act as antagonists and play a pivotal role in neutralising the soil borne plant pathogens, thereby assisting in the bio-control of diseases. Application of biofertilisers in lieu of synthetic fertilizers could be the promising technique to raise agricultural productivity without degrading the environmental quality. The present book focuses on the latest research approaches and updates from the microbiota ecosystem and their applications in agriculture industry. It also highlights the great potential and possible future of action of microbiota in the development of sustainable agricultural systems.
    Type of Medium: Online Resource
    Pages: XXI, 297 p. 53 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030487713
    Language: English
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  • 21
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides the most cutting edge technologies related to the study of integrin activation and the characterization of their vast interactomes. Chapters detail protocols on experimental approached to quantify focal adhesion parameters, integrin activation, and the lateral interaction of integrins with transmembrane binding partners. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Integrin Interactome: Methods and Protocols aims to give the reader a multi-scale journey from single bonds inside protein structures to the function of these crucial adhesion receptors at a whole organism level in physiology and pathology.
    Type of Medium: Online Resource
    Pages: XIX, 315 p. 54 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071609620
    Series Statement: Methods in Molecular Biology, 2217
    Language: English
    Note: Measurement of Integrin Activation and Conformational Changes on the Cell Surface by Soluble Ligand and Antibody Binding Assays -- Quantification of Integrin Activation and Ligation in Adherent Cells -- Multi-parametric Analysis of Focal Adhesions in Bi-Dimensional Substrates -- Focal Adhesion Isolation Assay using ECM Coated Magnetic Beads -- Functional Integrin Regulation through Interactions with Tetraspanin CD9 -- Proximity-dependent Biotinylation (BioID) of Integrin Interaction Partners -- Analyzing the Integrin Adhesome by in situ Proximity Ligation Assay -- Single-Protein Tracking to Study Protein Interactions during integrin-based Migration -- Biochemical Characterization of the Integrin Interactome -- Network Analysis of Integrin Adhesion Complexes -- Surface Patterning for the Control of Receptor Clustering and Molecular Forces of Integrin-mediated Adhesions -- Dynamics and Physics of Integrin Activation in Tumour Cells by Nano-Sized Extracellular Ligands and Electromagnetic Fields -- Genetic Instruction of Megakaryocytes and Platelets Derived from Human Induced Pluripotent Stem Cells for Studies of Integrin Regulation -- Quantitative Analysis of Integrin Trafficking -- Methods to Study Integrin Functions on Exosomes -- Functional Bioinformatics Analyses of the Matrisome and Integrin Adhesome -- Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells. .
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  • 22
    Online Resource
    Online Resource
    Cham : : Springer International Publishing :
    In: Springer Nature eBook
    Description / Table of Contents: Economic archaeology and ancient economic history have boomed the past decades. The former thanks to greatly enhanced techniques to identify, collect, and interpret material remains as proxies for economic interactions and performance; the latter by embracing the frameworks of new institutional economics. Both disciplines, however, still have great difficulty talking with each other. There is no reliable method to convert ancient proxy-data into the economic indicators used in economic history. In turn, the shared cultural belief-systems underlying institutions and the symbolic ways in which these are reproduced remain invisible in the material record. This book explores ways to bring both disciplines closer together by building a theoretical and methodological framework to evaluate and integrate archaeological proxy-data in economic history research. Rather than the linear interpretations offered by neoclassical or neomalthusian models, we argue that complexity economics, based on system theory, offers a promising way forward. .
    Type of Medium: Online Resource
    Pages: XIX, 363 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030478988
    Series Statement: Palgrave Studies in Ancient Economies,
    Language: English
    Note: Chapter 1: Introduction: Finding a new approach to ancient proxy data -- Part I- Theoretical Frameworks and Methodologies -- Chapter 2: Playing by whose rules? Institutional resilience, conflict and change in the Roman economy -- Chapter 3: Networks as Proxies: a relational approach towards economic complexity in the Roman period -- Chapter 4: Evaluating the potential of computational modelling for informing debates on Roman economic integration -- Chapter 5: Visualising Roman institutional environments for exchange as a complex system -- PART II- Urban Systems -- Chapter 6: Social complexity and complexity economics. Studying socio-economic systems at Düzen Tepe and Sagalassos (SW Turkey) -- Chapter 7: A method for estimating Roman population sizes from urban survey contexts: an application in central Adriatic Italy -- Chapter 8: Complexity and urban hierarchy of ancient urbanism: the cities of Roman Asia Minor -- PART III- Epidemics -- Chapter 9: Disease proxies and the diagnosis of the late Antonine economy -- Chapter 10: Measuring and Comparing Economic Interaction Based on the Paths and Speed of Infections. The Case Study of the Spread of the Justinianic Plague and Black Death.
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  • 23
    Online Resource
    Online Resource
    Berlin, Heidelberg : : Springer Berlin Heidelberg :
    In: Springer Nature eBook
    Description / Table of Contents: Homo sapiens hat zunehmend Energiehunger! Mächtige Angst vor dem Weltuntergang wegen des Kohlendioxids, welches bei der Energieerzeugung entsteht, hat er aber auch. Wer und wo sind eigentlich die wahren Energiefresser? Energie ohne Kohlendioxid kann man haben, aber teils sehr extensiv, teils auf gefährliche Art. Und wenn man das Kohlendioxid aus der Atmosphäre über Pflanzen und von denen weiter über Wärmekraftmaschinen zurück zur Atmosphäre bringt? Ist mit einem solchen Kohlendioxidkreislauf die Erderwärmung vermeidbar, oder ist ein Wasserkreislauf über die Maschinen sauberer? Der Autor formuliert Thesen die meist überraschend sind, aber im Buch auf verständliche Weise begründet werden. Professor Cornel Stan hat Luft- und Raumfahrttechnik studiert und lehrte in Berkeley, Paris, Pisa und an weiteren Universitäten zwischen Transsylvanien und Galicien über Energieumwandlung und anwendung in technischen Systemen, sowie über Alternative Antriebe für Automobile Er leitete über zwei Jahrzehnte lang das Forschungs- und Transferzentrum an der Westsächsischen Hochschule Zwickau. Cornel Stan ist Autor zahlreicher Fachbücher und Romane, die in mehreren Sprachen erschienen sind.
    Type of Medium: Online Resource
    Pages: XI, 230 S. 9 Abb. in Farbe. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783662627068
    Series Statement: Springer Protocols
    Language: German
    Note: Energie und Kohlendioxid -- Verursacher Kohlendioxidemission -- Energie ohne Kohlendioxid -- Energie nutzt Kohlendioxid -- Zusammenfassung der Thesen. .
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  • 24
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR/Cas9 delivery vehicle. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Nanotherapy for Brain Tumor Drug Delivery is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors. .
    Type of Medium: Online Resource
    Pages: XIII, 298 p. 53 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071610527
    Series Statement: Neuromethods, 163
    Language: English
    Note: Glioblastoma: State of Art of Treatments and Application of Polymeric and Lipidic Nanomedicines -- Passive and Active Targeting of Brain Tumors -- Strategies to Modulate the Blood Brain Barrier for Directed Brain Tumor Targeting -- Drug Delivery Approaches and Imaging Techniques for Brain Tumor -- Surface-Modified Nano-Drug Carriers for Brain Cancer Treatment -- Inorganic Nanostructures for Brain Tumor Management -- Strategies to Enhance the Distribution of Therapeutic Nanoparticles in the Brain by Convection Enhanced Delivery -- Focused Ultrasound-Mediated Blood-Brain Barrier Disruption for Enhanced Drug Delivery to Brain Tumors -- Neurosurgical Implant-Based Strategy for Brain Cancer Therapy -- Liposome-Templated Hydrogel Nanoparticles for Targeted Delivery of CRISPR/Cas9 to Brain Tumors -- Methods to Separate, Characterize, and Encapsulate Drug Molecules into Exosomes for Targeted Delivery and Treatment of Glioblastoma -- Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development.
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  • 25
    Online Resource
    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest techniques used to better understand the brain reward system with respect to neurotransmitters, brain structures, and connectivity. This book aims to show readers tested laboratory protocols to study neural circuitry and biological processes implicated in reward, and in neuropsychiatric disorders such as substance use disorders. The chapters are organized into four parts. Part One addresses classical techniques to study the brain reward system, including the curve shift paradigm in intracranial self-stimulation, stereotaxic surgery in rodents, and the use of brain lesions. Part Two focuses on neurochemical, behavioral, and chemogenetic techniques such as immunofluorescence for assessing adult hippocampal neurogenesis, and fast-scan voltammetry. Part Three highlights methods used to assess the rewarding potential of drugs including intracranial self-stimulation combined with drug injection, and the use of viral vectors. The Fourth Part introduces imaging and electrophysiology techniques such as positron emission tomography, in vivo electrophysiology, and fiber photometry. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, The Brain Reward System is a valuable resource for researchers interested in learning more about the current methods used to study the delineation of the brain reward system.
    Type of Medium: Online Resource
    Pages: XIII, 366 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071611463
    Series Statement: Neuromethods, 165
    Language: English
    Note: Intracranial Self-Stimulation and the Curve-Shift Paradigm: A Putative Model to Study the Brain Reward System -- Stereotaxic Surgery in Rodents for Stimulation of the Brain Reward System -- Characterizing the Neural Substrate of Reward with the Use of Specific Brain Lesions -- Assessment of Adult Hippocampal Neurogenesis: Implication for Neurodegenerative Diseases and Neurological Disorders -- Fast-Scan Voltammetry for In Vivo Measurements of Neurochemical Dynamics -- Carbon Fiber Probes for Real-Time Monitoring of Dopamine -- Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair -- Behavioral Tests for Assessing Pain and Nociception: Relationship with the Brain Reward System -- Chemogenetic (DREADD) Exploration of Circuits Mediating Reward-Motivated Attention -- Intracranial Self-Stimulation: Using the Curve-Shift Paradigm to Assess the Abuse Potential of Drugs -- Drug Self-Administration as a Model to Study the Reward System -- Viral Vectors for Studying Drug-Seeking Behavior -- Conditioned Place Preference Test for Assessing the Rewarding Effects of Drugs of Abuse -- Positron Emission Tomography of the Reward System -- In Vivo Electrophysiology for Reward Anticipation and Processing -- Fiber Photometry of Neural Activity in Specific Neural Circuit -- Two-Photon Microscopy for Studying Reward Circuits of the Brain. .
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  • 26
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    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This fully updated edition explores conceptual as well as technical guidelines for plant taxonomists and geneticists, such as the increasing use of next-generation sequencing (NGS) technologies for numerous applications in plant taxonomy. The volume provides molecular approaches to be used within an “integrative taxonomy” framework, combining a range of nucleic acid and cytogenetic data together with other crucial information (taxonomy, morphology, anatomy, ecology, reproductive biology, biogeography, paleobotany, etc.), which will help not only to best circumvent species delimitation but also to resolve the evolutionary processes in play. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Molecular Plant Taxonomy: Methods and Protocols, Second Edition is an ideal guide for researchers seeking a better understanding of evolutionary processes, at species and population level, through molecular techniques.
    Type of Medium: Online Resource
    Pages: XIII, 400 p. 78 illus., 49 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9781071609972
    Series Statement: Methods in Molecular Biology, 2222
    Language: English
    Note: Plant Taxonomy: A Historical Perspective, Current Challenges, and Perspectives -- Guidelines for the Choice of Sequences for Molecular Plant Taxonomy -- Isolation and Purification of DNA from Complicated Biological Samples -- Herbarium Specimens: A Treasure for DNA Extraction, an Update -- Sequencing of Complete Chloroplast Genomes -- Utility of the Mitochondrial Genome in Plant Taxonomic Studies -- Nuclear Ribosomal RNA Genes: ITS Region -- Plant DNA Barcoding Principles and Limits: A Case Study in the Genus Vanilla -- High-Throughput Genotyping Technologies in Plant Taxonomy -- Genotyping-by-Sequencing Technology in Plant Taxonomy and Phylogeny -- Development of Microsatellite Markers Using Next-Generation Sequencing -- Amplified Fragment Length Polymorphism: Applications and Recent Developments -- Randomly Amplified Polymorphic DNA (RAPD) and Derived Techniques -- Inter Simple Sequence Repeats (ISSR), Microsatellite-Primed Genomic Profiling Using Universal Primers -- Retrotransposable Elements: DNA Fingerprinting and the Assessment of Genetic Diversity -- Introduction to Population Genomics Methods -- The Application of Flow Cytometry for Estimating Genome Size, Ploidy Level Endopolyploidy, and Reproductive Modes in Plants -- Molecular Cytogenetics (FISH and Fluorochrome Banding): Resolving Species Relationships and Genome Organization -- GISH: Resolving Interspecific and Intergeneric Hybrids.
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  • 27
    Call number: Z070:540
    Type of Medium: Unknown
    Pages: 368 p.
    ISBN: 9783800754052
    Series Statement: VDE-Schriftenreihe Normen verständlich ; 177
    Language: English
    Location: Z070
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  • 28
    In: Springer Nature eBook
    Description / Table of Contents: This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.
    Type of Medium: Online Resource
    Pages: XII, 266 p. 78 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9781071610916
    Series Statement: Methods in Molecular Biology, 2240
    Language: English
    Note: The Single Cell Gel Electrophoresis Genotoxin Sensitivity Assay -- Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency Assay -- Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation -- Intravital Microscopy: A Tool to Investigate the Toxicity in the Immune System, Vessel Rheology, and Xenobiotic Distribution -- Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment -- In Vitro Contraction of Isolated Cauda Epididymal Duct Smooth Muscle as a Complimentary Approach to Physiological, Pathological, Toxicological, and Pharmacological Studies on Epididymal Function -- Early Life Stage Assays in Zebrafish -- Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ -- Evaluation of Development of the Rat Uterus as a Toxicity Biomarker -- Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish -- Ecotoxicity Assays Using Freshwater Planarians -- Toxicogenomic Analysis -- Strategy Combining Non-Animal Methods for Ocular Toxicity Evaluation -- Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids in Alginate Beads -- Oxygen Consumption Evaluation: An Important Indicator of Metabolic State, Cellular Function and Cell Fate Along Neural Deregulation -- Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment -- In Vitro Apoptotic Cell Death Assessment.
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  • 29
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    Online Resource
    New York, NY : : Springer US :
    In: Springer Nature eBook
    Description / Table of Contents: This detailed new edition presents the latest developments of the main pillars of protein analysis, namely sample preparation, separation, and characterization. Core areas in this volume are protocols for the analysis of post-translational modifications and protein interaction partners, followed by sophisticated procedures to enrich for extracellular vesicles and organelles, along with several types of protein immuno-assays complemented by various methods for the characterization of antibodies and host-cell protein analysis. Last but not least, a few standard sample preparation protocols and recent advances concerning immuno-chemical detection of proteins are included as well. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Proteomic Profiling: Methods and Protocols, Second Edition serves as an ideal reference for students of biochemistry, biomedicine, biology, and genomics and will be an invaluable source for the experienced, practicing scientist as well.
    Type of Medium: Online Resource
    Pages: XV, 592 p. 131 illus., 91 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9781071611869
    Series Statement: Methods in Molecular Biology, 2261
    Language: English
    Note: How Modern Mass Spectrometry Can Solve Ancient Questions: A multi-Omics Study of the Stomach Content of the Oldest Human Ice Mummy, the 5300-Year-Old Iceman or Oetzi -- Step-by-Step Sample Preparation of Proteins for Mass Spectrometric Analysis -- Lab-on-a-Filter Techniques for Economical, Effective, and Flexible Proteome Analysis -- Released N-Glycan Analysis for Biotherapeutic Development Using Liquid Chromatography and Mass Spectrometry -- Comprehensive Protocol to Simultaneously Study Protein Phosphorylation, Acetylation, and N-Linked Sialylated Glycosylation -- Phos-Tag Fluorescent Gel Staining for the Quantitative Detection of His- and Asp-Phosphorylated Proteins -- Polyubiquitin Profile in Down Syndrome and Alzheimer Disease Brain -- Platform Methods to Characterize the Charge Heterogeneity of Three Common Protein Therapeutics by Imaged Capillary Isoelectric Focusing -- A Protocol for Isolation, Purification, Characterization, and Functional Dissection of Exosomes -- Human Plasma Extracellular Vesicle Isolation and Proteomic Characterization for the Optimization of Liquid Biopsy in Multiple Myeloma -- Isolation of Extracellular Vesicles for Proteomic Profiling -- Isolation of Proteins from Extracellular Vesicles (EVs) for Mass Spectrometry-Based Proteomic Analyses -- Flow Cytometry as an Important Tool in Proteomic Profiling -- Improved Immunoprecipitation to Mass Spectrometry Method for Enrichment of Low-Abundant Protein Targets -- Multiplex Fluorescent Bead-Based Immunoassay for the Detection of Cytokines, Chemokines, and Growth Factors -- Bead-Based Multiplex Immunoassays: Procedures, Tips, and Tricks -- Immunoaffinity-Based Liquid Chromatography Mass Spectrometric Assay to Accurately Quantify the Protein Concentration of HMGB1 in EDTA Plasma -- Recombinant Anti-Idiotypic Antibodies in Ligand Binding Assays for Antibody Drug Development -- cDNA Display-Mediated Immuno-PCR (cD-IPCR): An Ultrasensitive Immunoassay for Biomolecular Detection -- Chromatin Immunoprecipitation (ChIP) to Study DNA-Protein Interactions -- Profiling Protein-DNA Interactions by Chromatin Immunoprecipitation in Arabidopsis -- Biotin Proximity Labeling for Protein-Protein Interaction Discovery: The BioID Method -- Studying OTUD6B-OTUB1 Protein-Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays -- Thermal Shift Assay for Exploring Interactions between Fatty Acid-Binding Protein and Inhibitors -- Isolation and Purification of Mitochondria from Cell Culture for Proteomic Analyses -- Investigating the Adipose Tissue Secretome: A Protocol to Generate High Quality Samples Appropriate for Comprehensive Proteomic Profiling -- Methods for Proteomics-Based Analysis of the Human Muscle Secretome Using an In Vitro Exercise Model -- Western Blotting Using In-Gel Protein Labeling as a Normalization Control: Advantages of Stain-Free Technology -- Technical Considerations for Contemporary Western Blot Techniques -- Simple Western: Bringing the Western Blot into the 21st Century -- Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests -- Sample Preparation of Secreted Mammalian Host Cell Proteins and their Characterization by Two-Dimensional Electrophoresis and Western Blotting -- Quantitative Proteomic Analysis Using Formalin-Fixed Paraffin-Embedded (FFPE) Human Cardiac Tissue -- Chloroplast Isolation and Enrichment of Low Abundant Proteins by Affinity Chromatography for Identification in Complex Proteomes -- Principles of Protein Labeling Techniques -- Mechanical/Physical Methods of Cell Disruption and Tissue Homogenization.
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  • 30
    In: Springer Nature eBook
    Description / Table of Contents: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
    Type of Medium: Online Resource
    Pages: X, 320 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030511401
    Series Statement: Advances in Experimental Medicine and Biology, 1281
    Language: English
    Note: 1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder -- 2. The neuropsychiatry of frontotemporal dementia -- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia -- 4. Measuring Behavior and Cognition in FTLD -- 5. Clinical update on C9orf72: FTD, ALS and beyond -- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations -- 7. Neuroimaging in Frontotemporal Lobar Degeneration -- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies -- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration -- 10. Cross-cultural perspectives on frontotemporal degeneration -- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies -- 12. Tau protein and frontotemporal dementias -- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance -- 14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology -- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins -- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models -- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling -- 18. FTLD treatment: Current Practice and Future Possibilities.
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  • 31
    In: Springer Nature eBook
    Description / Table of Contents: The Atlantic Forest is one of the 36 hotspots for biodiversity conservation worldwide. It is a unique, large biome (more than 3000 km in latitude; 2500 in longitude), marked by high biodiversity, high degree of endemic species and, at the same time, extremely threatened. Approximately 70% of the Brazilian population lives in the area of this biome, which makes the conflict between biodiversity conservation and the sustainability of the human population a relevant issue. This book aims to cover: 1) the historical characterization and geographic variation of the biome; 2) the distribution of the diversity of some relevant taxa; 3) the main threats to biodiversity, and 4) possible opportunities to ensure the biodiversity conservation, and the economic and social sustainability. Also, it is hoped that this book can be useful for those involved in the development of public policies aimed at the conservation of this important global biome.
    Type of Medium: Online Resource
    Pages: XXX, 517 p. 66 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030553227
    Language: English
    Note: Part 1: Historical and biogeographical aspects -- The Atlantic Forest: an introduction to the megadiverse forest of Southern America -- The Atlantic Forest Ecological History: from pre-history to the Anthropocene -- The North-eastern Atlantic Forest: biogeographical, historical and current aspects in the Sugarcane Zone -- The Hileia Baiana - an assessment of natural and historical aspects of the land use and degradation of the central corridor of the Brazilian Atlantic Forest -- The southern Atlantic Forest: Use, degradation, and perspectives for conservation -- Part II – Biodiversity -- Tree diversity in the Brazilian Atlantic Forest: biases and general patterns using different sources of information -- Vascular Epiphytes of the Atlantic Forest: diversity and community ecology -- Social Insects of the Atlantic Forest -- Tetrapod diversity in the Atlantic Forest: maps and gaps -- Freshwater Studies in Atlantic Forest: general overview and prospects -- Part III – Threats -- Land-cover changes and an uncertain future: will the Brazilian Atlantic Forest lose the chance to become a hopespot? -- Climate change and biodiversity in the Atlantic Forest: best climatic models, predicted changes and impacts, and adaptation options -- Non-native species introductions, invasions, and biotic homogenization in the Atlantic Forest -- Causes and consequences of large-scale defaunation in the Atlantic forest -- Pollination systems in the Atlantic Forest: characterization, threats, and opportunities -- IV - Opportunities -- Atlantic Forest: ecosystem services linking people and biodiversity -- Changing the agriculture paradigm in the Brazilian Atlantic Forest: the importance of agroforestry -- Engaging people for large-scale forest restoration: Governance lessons from the Atlantic Forest of Brazil -- The Atlantic Forest Trail: connecting people, biodiversity and protected areas -- Conservation initiatives in the Brazilian Atlantic forest -- Financing conservation in the Brazilian Atlantic Forest -- Integrating researchers for understanding the biodiversity in Atlantic Forest -- The future of the Atlantic Forest.
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  • 32
    In: Springer Nature eBook
    Description / Table of Contents: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    Language: English
    Note: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
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  • 33
    In: Springer Nature eBook
    Description / Table of Contents: Pollution is one of the most serious issues facing mankind and other life forms on earth. Environmental pollution leads to the degradation of ecosystems, loss of services, economic losses, and various other problems. The eco-friendliest approach to rejuvenating polluted ecosystems is with the help of microorganism-based bioremediation. Microorganisms are characterized by great biodiversity, genetic and metabolic machinery, and by their ability to survive, even in extremely polluted environments. As such, they are and will remain the most important tools for restoring polluted ecosystems / habitats. This three-volume book sheds light on the utilization of microorganisms and the latest technologies for cleaning up polluted sites. It also discusses the remediation or degradation of various important pollutants such as pesticides, wastewater, plastics, PAHs, oil spills etc. The book also explains the latest technologies used for the degradation of pollutants in several niche ecosystems. Given its scope, the book will be of interest to teachers, researchers, bioremediation scientists, capacity builders and policymakers. It also offers valuable additional reading material for undergraduate and graduate students of microbiology, ecology, soil science, and the environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 398 p. 37 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811574474
    Series Statement: Microorganisms for Sustainability, 25
    Language: English
    Note: Chapter 1: Rhizosphere - Niche for Microbial Rejuvenation and Biodegradation of Pollutants -- Chapter 2: Bioremediation of Pesticides: An Eco-friendly Approach for Environment Sustainability -- Chapter 3: Microbial Indicators of Bioremediation-Potential and Success -- Chapter 4: Phycoremediation: A Sustainable Biorefinery Approach -- Chapter 5: Cyanobacteria Mediated Bioremediation of Problem Soils -- Chapter 6: VAM- An Alternate Strategy for Bioremediation of Polluted Environment -- Chapter 7: Strategies to Improve Remediation Technology Using Fungi -- Chapter 8: Bioremediation of Polluted Soil by Using Plant Growth Promoting Rhizobacteria -- Chapter 9: The Utilization of Microbial Biofilm for the Biotransformation and Bioremediation of heavily Polluted Environment -- Chapter 10: Microbes: A Novel Source of Bioremediation for Degradation of Hydrocarbon -- Chapter 11: Microbial Bioremediation of Petroleum Hydrocarbons.-Chapter 12: Potential of Extremophiles for Bioremediation -- Chapter 13: Role of Microbes in Bioremediation of Radioactive Waste -- Chapter 14: Plastic Eating Microorganism: Recent Biotechnological Techniques for Recycling of Plastic -- Chapter 15: Bioaugmentation: A Powerful Biotechnological Techniques for Sustainable Ecorestoration of Soil and Groundwater Contaminants.
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  • 34
    In: Springer Nature eBook
    Description / Table of Contents: Pollution is one of the most serious issues facing mankind and other life forms on earth. Environmental pollution leads to the degradation of ecosystems, loss of services, economic losses, and various other problems. The eco-friendliest approach to rejuvenating polluted ecosystems is with the help of microorganism-based bioremediation. Microorganisms are characterized by great biodiversity, genetic and metabolic machinery, and by their ability to survive, even in extremely polluted environments. As such, they are and will remain the most important tools for restoring polluted ecosystems / habitats. This three-volume book sheds light on the utilization of microorganisms and the latest technologies for cleaning up polluted sites. It also discusses the remediation or degradation of various important pollutants such as pesticides, wastewater, plastics, PAHs, oil spills etc. The book also explains the latest technologies used for the degradation of pollutants in several niche ecosystems. Given its scope, the book will be of interest to teachers, researchers, bioremediation scientists, capacity builders and policymakers. It also offers valuable additional reading material for undergraduate and graduate students of microbiology, ecology, soil science, and the environmental sciences.
    Type of Medium: Online Resource
    Pages: XVI, 358 p. 27 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811574597
    Series Statement: Microorganisms for Sustainability, 27
    Language: English
    Note: Chapter 1: Strain Improvement and Mass Production of Beneficial Microorganisms for Their Environmental and Agricultural Benefit -- Chapter 2: Biochemical Role of Beneficial Microorganisms: An Overview on Recent Development in Environmental and Agro-Science -- Chapter 3: Recent Advances in Application of Microbial Enzymes for Biodegradation Waste and Hazardous Waste Material -- Chapter 4: Biological, Biochemical and Biodiversity of Biomolecules from Marine based beneficial Microorganisms: Industrial Perspective -- Chapter 5: Climate Change and Pesticides: Their Consequence on Microorganisms -- Chapter 6: Effect of Heavy Metals on Activities of Soil Microorganism -- Chapter 7: Microbial Community Dynamics in Anaerobic Digestors for Biogas Production -- Chapter 8: Effect of Microbially Produced Silver Nanoparticles on Bioremediation of Waste Dye: Nanobioremediation -- Chapter 9: Bioremoval of Fluoride: Process and Mechanism -- Chapter 10: A Critical Review of Microbial Transport in Effluent Waste and Sewage Sludge Treatment -- Chapter 11: Recent Trends in Utilization of Biotechnological Tools for Environmental Sustainability -- Chapter 12: Artificial Intelligence and Internet of Things in Instrumentation and Control in Waste Biodegradation Plants: Recent Developments -- Chapter 13: Bioremediation of Polythene and Plastics Using Beneficial Microorganisms -- Chapter 14: Recent Advances in the Application of Genetically Engineered Microorganisms for Microbial Rejuvenation of Contaminated Environment -- Chapter 15: Efficacy of Microorganisms in the Removal of Toxic Materials from Industrial Effluents.
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  • 35
    In: Springer Nature eBook
    Description / Table of Contents: Nanomedicine is the field of science that deals with organic applications of medicine at the nanoscale level. It primarily addresses finding, anticipating, and treating sickness, as well as using nanotechnology to assist in controlling human frameworks at the cellular level. The nature of nanotechnology allows it to address numerous medical issues in humans. This book offers comprehensive information to better comprehend and apply multifunctional nanoparticles in nanomedicine, and thus open avenues in the field. Medicating at the nanolevel is an exceptional therapeutic avenue, as it avoids symptoms associated with conventional medicines. This book investigates recent insights into structuring novel drug delivery frameworks. It concentrates on the physical characteristics of drug delivery transporters, and the preliminary procedures involved in their use. The book offers in-depth detail that benefits academics and researchers alike, containing broad research from experts in the field, and serves as a guide for students and researchers in the field of nanomedicine, drug delivery, and nanotechnology.
    Type of Medium: Online Resource
    Pages: XIII, 265 p. 38 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030610210
    Series Statement: Nanotechnology in the Life Sciences,
    Language: English
    Note: Preface -- Nanomedicine: General Introduction from A to Z -- Immunology and Nanotechnology: Effects and Affects -- Role of Nanotechnology in Sensor Development -- Nanotechnology in the Characterization of Cancer -- Nano Vaccine -- Nanotechnology in Theranostics and In Vivo Imaging -- The Implication of Physical and Chemical Characterization of Therapeutic and Imaging Applications -- Polymers in Nanomedicine -- Delivery of Drug Payloads to Organs and Organ-Systems of Human Beings -- Drug Delivery Towards Cancer -- Drug Delivery Towards Malaria -- Nanotechnology in Tissue Engineering and Implant Development -- Interactions Between Nano-Delivery Agents and Immune Systems -- The Fate of Drug Delivery Agents after Delivery of Payload -- Index.
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  • 36
    In: Springer Nature eBook
    Description / Table of Contents: The ever-rising increase in the consumption of medicinal herbs and its products and its exposure in the human population have generated concerns about the potential neurotoxicity of several new and existing botanicals. This book offers an accurate, relevant, and comprehensive coverage of a wide variety of medicinal herbs and fungi affecting the central and peripheral nervous system. It includes review articles that thoroughly describe the benefits and adverse effects of some of the most commonly used medicinal herbs and fungi, and the pathophysiological mechanisms underlying them. The book provides an all-inclusive overview of the diverse aspects of medicinal herbs and fungi related to neurotoxicity and/or neuroprotection, ranging from discussions of cellular and molecular processes and pathology to clinical aspects. The rich compilation brings together thorough and extensive research updates on the advances in the field. The chapters have been contributed by the experienced and eminent academicians, researchers, and scientists working in the field across the globe.
    Type of Medium: Online Resource
    Pages: XXII, 510 p. 74 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341418
    Language: English
    Note: Chapter 1. Mitosis Inhibitors and Medicinal Plants – Neurotoxicity and Neuroprotection.-Chapter 2. The Neurotrophic and Neuroprotective Potential of Macrofungi -- Chapter 3. Andrographolide, a Diterpene from Andrographis paniculata, and Its Influence on the Progression of Neurodegenerative Disorders -- Chapter 4 Ginseng: A Boon or a Curse to Neurodegenerative Diseases -- Chapter 5 Insights into Mechanisms and Models for Studying Neurological Adverse Events Mediated by Pharmacokinetic Interactions Between Clinical Drugs and Illicit Substances of Herbal and Fungal Origin -- Chapter 6 Cannabis Induced Neuroactivity: Research Trends and Commercial Prospects -- Chapter 7 Neurotoxicity of Polyherbal Formulations: Challenges and Potential Solutions -- Chapter 8 Balancing the Neuroprotective Versus Neurotoxic Effects of Cannabis -- Chapter 9 Alpha-Synuclein: Biomarker for Parkinson’s Disease, It’s Estimation Methods and Targeted Medicinal Therapies -- Chapter 10 Screening of Herbal Medicines for Neurotoxicity: Principles and Methods -- Chapter 11 Plants with Phytomolecules Recognized by Receptors in The Central Nervous -- Chapter 12 Reserpine Induced Depression and Other Neurotoxicity: A Monoaminergic Hypothesis -- Chapter 13 Traditional Medicinal Plants of Sri Lanka and Their Derivatives of Benefit to the Nervous System -- Chapter 14 Ameliorative Effects of Shodhana (Purification) Procedures on Neurotoxicity Caused by Ayurvedic Drugs of Mineral and Herbal Origin -- Chapter 15 St. John’s Wort: A Therapeutic Herb to be Cautioned for Its Potential Neurotoxic Effects and Major Drug Interactions -- Chapter 16. Neurotoxic Potential of Alkaloids from Thorn Apple (Datura stramonium L.) - A Commonly Used Indian Folk Medicinal Herb -- Chapter 17 Medicinal Plants in Uganda as Potential Therapeutics Against Neurological Disorders -- Chapter 18 Ayurvedic Ideology on Rasapanchak Based Cognitive Drug Intervention -- Chapter 19 Neurotoxic Medicinal Plants of Indian Himalayan Regions: An Overview -- Chapter 20.Neuroprotective Effects of Portulaca oleracea and Portulaca quadrifida Linn. .
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  • 37
    In: Springer Nature eBook
    Description / Table of Contents: With more than 1,400 species, bats are an incredibly diverse and successful group of mammals that can serve as model systems for many unique evolutionary adaptations. Flight has allowed them to master the sky, while echolocation enables them to navigate in the dark. Being small, secretive, nocturnal creatures has made bats a challenge to study, but over the past 50 years, innovative research has made it possible to dispel some of the mystery and myth surrounding them to give us a better understanding of the role these animals play in the ecosystem. The structure of the book is based on several broad themes across the biological sciences, including the evolution of bats, their ecology and behavior, and conservation of biodiversity. Within these themes are more specific topics on important aspects of bat research, such as morphology, molecular biology, echolocation, taxonomy, systematics, threats to bats, social structure, reproduction, movements, and feeding strategies. Given its scope, the book will appeal to the wider scientific community, environmental organizations, and government policymakers who are interested in the interdisciplinary aspects of biology and nature.
    Type of Medium: Online Resource
    Pages: XIII, 374 p. 63 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030547271
    Series Statement: Fascinating Life Sciences,
    Language: English
    Note: Chapter 1. Introduction and implementation of harp traps signal a new era in bat research -- Chapter 2. Bats as Hosts of Important Unicellular Endoparasites -- Chapter 3. A global review of phylogeographic studies on bats -- Chapter 4. All the Better to Eat You With: The Legacy of James S. Findley’s Phenetic Approach to Bat Biology -- Chapter 5. Fur, wings, and flowers: development and progress on nectarivorous bat research in the last 50 years -- Chapter 6. The Winter Worries of Bats: Past and Present Perspectives on Winter Habitat and Management of Cave Hibernating Bats -- Chapter 7. Integrating physiological and behavioral traits with ontogeny, phylogenetic history, and survival and fitness to understand heterothermy in bats -- Chapter 8. Molecular biology in the evolution of bats: a historical perspective -- Chapter 9. Molecular biology in the evolution of bats: a historical perspective -- Chapter 10. The evolution of acoustic methods for the study of bats -- Chapter 11. Bats, Bat Flies, and Fungi: Exploring Uncharted Waters -- Chapter 12. Bats and the Ecological and Evolutionary Consequences of Resource Spatio-temporal Predictability (STP) -- Chapter 13. There and Back Again: Homing in Bats Revisited -- Chapter 14. A NASBR history of radiotelemetry–how technology has contributed to advances in bat biology -- Chapter 15. Bats Flying at High Altitudes -- Chapter 16. Contributions of Women and Creating a Culture of Inclusivity at the North American Society for Bat Research -- Chapter 17. Pioneers of bat habitat and resource selection -- Chapter 18. NASBR Origins 1970-2020: From an Informal Gathering to a Scientific Society -- Chapter 19. The Importance of Water Availability to Bats: Climate Warming and Increasing Global Aridity -- Chapter 20. Bats as reservoirs of viral zoonoses -- Chapter 21. Bats in temperate forests: where are the trends in bat populations? -- Chapter 22. How noise affects bats and what it reveals about their biosonar systems.
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  • 38
    Online Resource
    Online Resource
    Cham : : Springer International Publishing :
    In: Springer Nature eBook
    Description / Table of Contents: The book is intended as a guide for molecular biology students, equipping them to successfully study plants. It pursues a holistic approach, viewing the whole plant as an integrated operating organism, and is written in a straightforward manner, making it appealing to anyone interested in plants. Further, it reflects the latest findings for scientists and students in the fields of plant sciences, biology, agriculture, forestry, ecology, vascular medicine and cancer, discussing e.g. how hormonal signals induce and regulate simple and complex patterns in plants vascular tissues, their adaptation and evolution. • written by a world-renowned expert who has worked in the field for 50 years • covers the field from the initial studies conducted more than a century ago up to recent studies with up-to-date explanations • describes in details the structure, development, physiology and basic molecular biology of plants’ vascular tissues, their function, regeneration and environmental adaptation • explores the controlling mechanisms of plant vascular differentiation by continuously moving hormonal signals and their precursors • discusses the regulation of stem cells and cambium, control of gradients in vascular cell size along the plant, juvenile-adult transition and rejuvenation, grafting, mechanisms of recovery from bending by reaction wood, evolution of vessels and fibers from tracheids, regulation of ring-porous wood evolution, protecting mechanisms against insects and pathogens, parasitism, plant cancer, and more • helps readers understand the scope and breadth of plant vascular systems in 20 detailed, high-quality chapters • includes a wealth of outstanding original color photographs and illustrations documenting the formation of vascular tissues • provides an in-depth understanding of plant biology by studying their vascular tissues.
    Type of Medium: Online Resource
    Pages: LXIII, 339 p. 135 illus., 81 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030532024
    Language: English
    Note: Introduction -- Structure, Development and Patterns of Primary, Secondary and Regenerative Vascular Tissues -- The Hormonal Signals that Regulate Plant Vascular Differentiation -- Importance of NO3- and PO4- for Development, Differentiation and Competition -- Phloem and Xylem Differentiation -- Apical Dominance and Vascularization -- Leaf Development and Vascular Differentiation -- Flower Biology and Vascular Differentiation -- Can a Differentiating Vessel Induce Lateral Root Initiation? -- Vascular Regeneration and Grafting -- Regulation of Cambium Activity -- Regulation of Juvenile-Adult Transition and Rejuvenation -- The Control of Tracheid Size, Vessel Widening and Density along the Plant Axis -- Circular Vascular Tissues, Vessel Endings and Tracheids in Organ Junctions -- Ray Differentiation – the Radial Pathways -- Environmental Adaptation of Vascular Tissues -- Resin Glands and Traumatic Duct Formation in Conifers -- Hormonal Control of Reaction Wood Formation -- Hormonal Control of Wood Evolution -- How Vascular Differentiation in Hosts Is Regulated by Parasitic Plants and Gall-Inducing Insects -- Cancer and Vascular Differentiation.
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  • 39
    In: Springer Nature eBook
    Description / Table of Contents: This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.
    Type of Medium: Online Resource
    Pages: XII, 663 p. 241 illus., 197 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9789811587634
    Series Statement: Advances in Experimental Medicine and Biology, 1293
    Language: English
    Note: Part 1. Light-sensitive channels and transporters -- 1. History and Perspectives of Light-Sensing Proteins -- 2. Phototactic behavior of Chlamydomonas -- 3. Structure-Functional Analysis of rhodopsin light sensors -- 4. Molecular Dynamics of Channelrhodopsin -- 5. Photochemistry of Halorhodopsin -- 6. Spectroscopic Dynamics of Microbial Rhodopsins -- 7. Molecular Engineering of Retinylidene Proteins -- 8. A new optogenetic tools from deep ocean -- Part 2. Light-sensitive signaling molecules -- 9. Biology of Light-Sensing Proteins in Plants and Microorganisms -- 10. Optogenetic Potentials of Diverse Animal Opsins -- 11. Enzyme rhodopsins -- 12.Optogenetic photoswitches -- 13.Genetic, biochemical and biophysical studies on flavoprotein photoreceptors -- Part 3. Optogenetics in Biological System -- 14. General Description: Future Prospects of Optogenetics -- 15. Optogenetic Manipulation and Probing -- 16. Visualization and Manipulation Signaling Molecules In Vivo -- 17. Optical Manipulation of Gene Expression -- 18. Optical Manipulation of Intracellular Signaling -- 19. Single Molecule Optogenetics -- 20. Bioluminescence Imaging -- 21. Luminescence Optogenetics -- 22. Optogenetic Imaging of Protein Activity in the Synapse Using 2-Photon Fluorescence Lifetime Imaging Microscopy -- 23. Optogenetics in Drosophila -- 24. Optogenetics in Caenorhabditis elegans -- 25. Optogenetics in zebrafish -- 26. Optogenetics Research Using the Mouse as a Model System -- 27. Optogenetics Research Using Rat -- 28. Optogenetics Research Using Primates -- 29. Organelle Optogenetics -- Part 4. Optogenetics in Neuroscience -- 30. Neuroscientific Frontline of Optogenetics -- 31. Elucidation of Neuronal Circuitry Involved in the Regulation of Sleep/Wakefulness Using Optogenetics -- 32. Multiscale neural activity in the behaving brain -- 33. Optogenetic Analysis of Striatal Connections to Determine Functional Connectomes -- 34. Optogenetics for the Behavior Manipulation of Non-human Primates -- 35. Activity Regulation in the Study of Neural Plasticity -- 36. Optogenetic Control of Synaptic Plasticity -- 37. Casting Light on the Role of Glial Cells in Brain Function -- 38. Optogenetic manipulation of Respiratory Rhythm -- 39. Optogenetic mapping of brain circuitry -- 40. In vivo imaging of Arc transcription -- 41. Neural Circuits for the Formation and Retrieval of Episodic Memories -- Part 5. Medical Optogenetics -- 42. Medical Optogenetics, Overview -- 43. Towards Understanding the Neural Mechanism of Behavioral Phenotypes Seen in Psychiatric Disorders -- 44. Gene Therapy Using Channelrhodopsins to Treat Blindness -- 45. Optogenetic Approaches to Restoring Intrinsic Visual Processing Features in Retinal Ganglion Cells -- 46. Application of optogenetics to epilepsy research -- Part 6. Opto-electro-nano Technologies for Optogenetics -- 47. CMOS-Based Neural Interface Device for Optogenetics -- 48. OLED System for Optogenetics -- 49. Micro-imaging probes, Opto-electrodes, and Virtual Reality Systems for Optogenetics -- 50. Upconversion -- 51. Optical probes for in vivo optogenetics.
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  • 40
    In: Springer Nature eBook
    Description / Table of Contents: Antibiotics have drastically improved the health and life expectancy of humans, yet the abrupt increase of antibiotic usage for animals, agriculture and healthcare has induced antimicrobial resistance. Antimicrobial resistance is leading to resurgence of deadly infectious diseases, calling for new cures. This book presents advanced therapies based on new and complementary drugs, and alternative techniques and strategies, such as phages, probiotics, flavonoids, essential oils, cellulose, peptides, nano delivery, iron starvation and vaccines.
    Type of Medium: Online Resource
    Pages: XV, 436 p. 66 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030582593
    Series Statement: Sustainable Agriculture Reviews, 49
    Language: English
    Note: Preface -- Chapter 1 Strategies for prevention and containment of antimicrobial resistance.-Chapter 2 Probiotics, Prebiotics and Synbiotics for the prevention of Antimicrobial Resistance -- Chapter 3 Plant natural products for mitigation of antibiotic resistance -- Chapter 4 Essential Oils as Potential Antimicrobial Agents -- Chapter 5 Polymeric Antimicrobials with Quaternary Ammonium Moieties -- Chapter 6 Nanoparticles: Powerful tool to mitigate antibiotic resistance -- Chapter 7 Antimicrobial Peptides and Peptidomimetics for the Control of Antibiotic Resistance -- Chapter 8 Exploiting the Achilles’ heel of iron dependence in antibiotic resistant bacteria with new anti-microbial iron withdrawal agents -- Chapter 9 Potential for phage biotechnology to mitigate antimicrobial resistance in agriculture -- Chapter 10 - The Role of Vaccines in Combating Antimicrobial Resistance.
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  • 41
    In: Springer Nature eBook
    Description / Table of Contents: This book compiles the latest applications of the cutting-edge gene editing tool CRISPR/Cas in the area of crop improvement. It begins with an introduction to the technique and its application in crop plants. Next, it gives an updated overview of available delivery methods, design tools and resources in CRISPR/Cas. The book subsequently reviews the applications of CRISPR/Cas in connection with e.g. insect stress, disease stress, abiotic stress, nutritional and yield improvement in crop plants, etc. It also discusses the various regulatory, ethical and social aspects of the technique that must be kept in mind when designing experiments. In closing, the book summarizes the status quo and outlines future prospects for the tool in crop improvement and food security. Given its scope, the book will especially benefit students and researchers in food science, biotechnology, agriculture and the plant sciences.
    Type of Medium: Online Resource
    Pages: XII, 306 p. 42 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811571428
    Language: English
    Note: Chapter 1. CRISPR/Cas System: An Introduction -- Chapter 2. CRISPR/Cas Based Techniques in Plants -- Chapter 3. Delivery Methods, Resources and Design Tools in CRISPR/Cas -- Chapter 4. CRISPR/Cas Based Insect Resistance in Crops -- Chapter 5. Disease Resistance in Crops Through CRISPR/Cas -- Chapter 6. CRISPR/Cas mediated Abiotic Stress Tolerance in Crops -- Chapter 7. Key Applications of CRISPR/Cas for Yield and Nutritional Improvement in Crop Plants -- Chapter 8. Applications of CRISPR/Cas beyond simple traits in Crops -- Chapter 9. Regulatory, Ethical and Social Aspects of CRISPR Crops -- Chapter 10. Challenges and Future Perspective of CRISPR/Cas Technology for Crop Improvement.
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  • 42
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    Singapore : : Springer Singapore :
    In: Springer Nature eBook
    Description / Table of Contents: This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.
    Type of Medium: Online Resource
    Pages: XI, 313 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341876
    Series Statement: Advances in Experimental Medicine and Biology, 1300
    Language: English
    Note: Part I Environmental Harmful Factors -- 1 Introduction to Environmental Harmful Factors -- Part II Female Reproductive Processes and Diseases -- 2 Introduction of Female Reproductive Processes and Reproductive Diseases -- Part III Effects of Environmental Factors on Reproductive Process -- 3 The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality -- 4 Effects of environment and lifestyle factors on premature ovarian failure -- 5 Effects of Environment and Lifestyle Factors on Anovulatory Disorder -- 6 Effects of Cigarette Smoking on Preimplantation Embryo Development -- 7 Toxicical effects of BPDE on dysfunctions of female trophoblast cells -- 8 The Roles of Stress-Induced Immune Response in Female Reproduction -- 9 Effects of Environmental EDCs on Oocyte Quality, Embryo Development and the Outcome in Human IVF Process -- Part IV Effects of Environmental Factors on Reproductive Diseases -- 10 Effects of environmental endocrine-disrupting chemicals on female reproductive health -- 11 Definition and Multiple Factors of Recurrent Spontaneous Abortion -- 12 The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and their Diagnosis Strategy -- Part V Effects of Environmental Factors on Fertility Preservation -- 13 The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.
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  • 43
    In: Springer Nature eBook
    Description / Table of Contents: This open access book describes the serious threat of invasive species to native ecosystems. Invasive species have caused and will continue to cause enormous ecological and economic damage with ever increasing world trade. This multi-disciplinary book, written by over 100 national experts, presents the latest research on a wide range of natural science and social science fields that explore the ecology, impacts, and practical tools for management of invasive species. It covers species of all taxonomic groups from insects and pathogens, to plants, vertebrates, and aquatic organisms that impact a diversity of habitats in forests, rangelands and grasslands of the United States. It is well-illustrated, provides summaries of the most important invasive species and issues impacting all regions of the country, and includes a comprehensive primary reference list for each topic. This scientific synthesis provides the cultural, economic, scientific and social context for addressing environmental challenges posed by invasive species and will be a valuable resource for scholars, policy makers, natural resource managers and practitioners.
    Type of Medium: Online Resource
    Pages: XLII, 455 p. 87 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030453671
    Language: English
    Note: Chapter 1. Introduction (Deborah C. Hayes, Becky K. Kerns, Toral Patel-Weynand, and Deborah M. Finch) -- Chapter 2. Impacts of Invasive Species in Terrestrial and Aquatic Systems in the United States (Albert E. Mayfield III, Steven J. Seybold, Wendell R. Haag, M. Tracy Johnson, Becky K. Kerns, John C. Kilgo, Daniel J. Larkin, Rima D. Lucardi, Bruce D. Moltzan, Dean E. Pearson, John D. Rothlisberger, Jeffrey D. Schardt, Michael K. Schwartz, and Michael K. Young) -- Chapter 3. Impacts of Invasive Species on Forest and Grassland Ecosystem Processes in the United States (Chelcy Ford Miniat, Jennifer M. Fraterrigo, Steven T. Brantley, Mac A. Callaham, Jr., Susan Cordell, Jeffrey S. Dukes, Christian P. Giardina, Shibu Jose, and Gary Lovett) -- Chapter 4. Effects of Climate Change on Invasive Species (Deborah M. Finch, Jack L. Butler, Justin B. Runyon, Christopher J. Fettig, Francis F. Kilkenny, Shibu Jose, Susan J. Frankel, Samuel A. Cushman, Richard C. Cobb, Jeffrey S. Dukes, Jeffrey A. Hicke, and Sybill K. Amelon) -- Chapter 5. Invasive Species Response to Natural and Anthropogenic Disturbance (Susan E. Meyer, Mac A. Callaham, Jr., Jane E. Stewart, and Steven D. Warren) -- Chapter 6. Early Intervention Strategies for Invasive Species Management: Connections Between Risk Assessment, Prevention Efforts, Eradication, and Other Rapid Responses (Robert C. Venette, Doria R. Gordon, Jennifer Juzwik, Frank H. Koch, Andrew M. Liebhold, Robert K.D. Peterson, Sharlene E. Sing, and Denys Yemshanov) -- Chapter 7. Management of Landscapes for Established Invasive Species (Therese M. Poland, Jennifer Juzwik, Allen Rowley, Cynthia D. Huebner, John C. Kilgo, Vanessa M. Lopez, Deanna H. Olson, Dean Pearson, Robert Progar, Robert Rabaglia, John D. Rothlisberger, Justin B. Runyon, and Sharlene E. Sing) -- Chapter 8. Restoration of Landscapes and Habitats Affected by Established Invasive Species (Jennifer Koch, Dean E. Pearson, Cynthia D. Huebner, Michael K. Young, and Richard A. Sniezko) -- Chapter 9. Sectoral Impacts of Invasive Species in the United States and Approaches to Management (Anne S. Marsh, Deborah C. Hayes, Patrice N. Klein, Nicole Zimmerman, Alison Dalsimer, Douglas A. Burkett, Cynthia D. Huebner, Robert Rabaglia, Laura A. Meyerson, Bonnie L. Harper-Lore, Jamie L. Davidson, Marla R. Emery, Travis Warziniack, Rebecca Flitcroft, Becky K. Kerns, and Vanessa M. Lopez) -- Chapter 10. Inventory and Monitoring of Invasive Species (Sonja Oswalt, Chris Oswalt, Alycia Crall, Robert Rabaglia, Michael Schwartz, and Becky K. Kerns) -- Chapter 11. Tools and Technologies for Quantifying Spread and Impacts of Invasive Species (Matt Reeves, Inés Ibáñez, Dana Blumenthal, Gang Chen, Qinfeng Guo, Catherine Jarnevich, Jennifer Koch, Frank Sapio, Michael K. Schwartz, Bruce K. Wylie, and Stephen Boyte) -- Chapter 12. Social and Cultural Dynamics of Non-Native Invasive Species (John Schelhas, Janice Alexander, Mark Brunson, Tommy Cabe, Alycia Crall, Michael J. Dockry, Marla R. Emery, Susan J. Frankel, Nina Hapner, Caleb R. Hickman, Rebecca Jordan, Michael J. LaVoie, Zhao Ma, Ross K. Meentemeyer, Joe Starinchak, and Jelena Vukomanovic) -- Chapter 13. The Role of International Cooperation in Invasive Species Research (Andrew Liebhold, Faith Campbell, Doria R. Gordon, Qinfeng Guo, Nathan Havill, Bradley Kinder, Richard MacKenzie, David R. Lance, Dean Pearson, Sharlene E. Sing, Travis Warziniack, Robert C. Venette, and Denys Yemshanov) -- Chapter 14. Economics of Invasive Species (Travis Warziniack, Robert G. Haight, Denys Yemshanov, Jenny L. Apriesnig, Thomas P. Holmes, Amanda M. Countryman, John D. Rothlisberger, and Christopher Haberland) -- Chapter 15. Legislation and Policy (Faith T. Campbell, Hilda Diaz-Soltero, and Deborah C. Hayes) -- Chapter 16. Future Invasive Species Research Challenges and Opportunities (Becky K. Kerns, Therese M. Poland, Robert C. Venette, Toral Patel-Weynand, Deborah M. Finch, Allen Rowley, Deborah C. Hayes, Mike Ielmini) -- APPENDIX 1: Regional Summaries.
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  • 44
    In: Springer Nature eBook
    Description / Table of Contents: Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.
    Type of Medium: Online Resource
    Pages: XXII, 181 p. 37 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030616632
    Series Statement: Advances in Experimental Medicine and Biology, 1297
    Language: English
    Note: Constituents of Cannabis Sativa -- Synthetic and Natural Derivatives of Cannabidiol -- Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions -- Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues -- Sleep-Wake Neurobiology -- Cannabinoids and Sleep/Wake Control -- Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals -- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence -- Natural Cannabinoids as Templates for Sleep Disturbances Treatment -- The Effect of Cannabinoids on the Brain´s Circadian Clock -- Effects of Cannabis Consumption on Sleep -- Addiction and Sleep Disorders -- Cannabis for Restless Legs Syndrome.
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  • 45
    In: Springer Nature eBook
    Description / Table of Contents: Most bioactive compounds have antioxidant activity, particularly tocochromanols, phenolics (flavonoids and phenolic acids), methylxantines and capsaicinoids. Some of these compounds have also other properties important for human health. For example, vitamin E protects against oxidative stress, but it is also known for its “non-antioxidant” functions, including cell signalling and antiproliferation. Selenium compounds and indoleamins are the components of the antioxidant enzymes. Selenium makes vitamin E acquisition easier and controls its physiological functions. In taking part in enzymatic reactions and protecting the cell against free radicals, selenium shows immunomodulative, antiphlogistic, and antiviral activity. Capsaicinoids possess not only antioxidant, but also antibacterial, analgesic, weight-reducing and thermoregulation properties. Studies have also demonstrated their gastroprotective and anticancer properties. Analytical Methods in the Determination of Bioactive Compounds and Elements in Food explores both the influence of particular compounds on human health and the methods used for their determination. Chapters describe various aspects of food and plant analysis, including chromatographic and non‐chromatographic approaches as well as hyphenated techniques. Readers of this book will gain a comprehensive understanding of the important groups of bioactive compounds relevant to human health.
    Type of Medium: Online Resource
    Pages: VIII, 380 p. 52 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030618797
    Series Statement: Food Bioactive Ingredients,
    Language: English
    Note: 1. Introduction – bioactive compounds and elements in human nutrition -- 2. Application of liquid chromatography for the analysis of flavonoids in food – an overview -- 3. Phenolic compounds in coffee and tea beverages -- 4. Methylxanthines in food products -- 5. Carotenoids as food products components and health promoting agents -- 6. Tocochromanols -- 7. Cyclitols - determination in food and bioactivity in the human organism -- 8. Capsaicinoids – properties and mechanisms of pro-health action -- 9. Dietary indoleamines: bioavailability and human health -- 10. Bioactive peptides analysis -- 11. Determination of antioxidant biomarkers in biological fluids -- 12. Speciation analysis of food products -- 13. Two sides of selenium. Occurrence and determination of selenium forms in food and environmental samples using analytical methods.
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  • 46
    In: Springer Nature eBook
    Description / Table of Contents: In order to understand common conditions such as coeliac disease and Crohn’s disease, one must view the gut in its evolutionary context. This is the novel approach to the gut and its diseases that is adopted in this book. The first part tells the story of the evolution of the gut itself – why it came about and how it has influenced the evolution of animals ever since. The second part focuses on the evolution of immunity and how the layers of immune mechanisms are retained in the gut, resembling the strata revealed in an archeological dig. The final part, ‘The Gastro-Archeologist’, ties the first two together and highlights how understanding the gut and immune system in their evolutionary context can help us understand diseases affecting them. Ambitious in its scope but telling a unique story from a refreshingly novel perspective, the book offers an informative and enjoyable read. As the story of the gut, immunity and disease unfolds, the author aims to endow readers with the same sense of awe and excitement that the subject evokes in him. Difficult concepts are illustrated using simple and colourful analogies, and the main content is supplemented with anecdotes and unusual and amusing facts throughout the book. The book is intended for anyone with an interest in the gut, its immunity and diseases, ranging from school and college biology and biomedical students, to professionals working in the field, and to patients suffering from intestinal diseases who want to understand more about their conditions.
    Type of Medium: Online Resource
    Pages: XVII, 304 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626211
    Language: English
    Note: Selection of the Fattest: The Invention of Eating -- The Gut Revolution -- The Bowels of Existence. The Intestinal Palimpsest: The Rules of Social Engagement -- The Orchestra of Life -- The Layers of Time. The Gastro-Archeologist: ‘What is Food to One is Rank Poison to Another’: food allergy and Intolerances -- The Evil bread: Coeliac disease and gluten related disorders -- Back to the very Beginning: The Inflammatory Bowel Diseases.
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  • 47
    Online Resource
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    Cham : : Springer International Publishing :
    In: Springer Nature eBook
    Description / Table of Contents: This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.
    Type of Medium: Online Resource
    Pages: XX, 490 p. 38 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030635497
    Series Statement: Physiology in Health and Disease,
    Language: English
    Note: Sex Differences in Respiratory Physiology -- Sex Differences in the Anatomy of the Airways and the Lungs: Impact on Dysanapsis across the Lifespan -- Sex Steroids and Their Influence in Lung Diseases Across the Lifespan -- Sex Differences in the Developing Lung: Implications for Disease -- Neonatal Lung Disease: Mechanisms Driving Sex Differences -- Sex Differences in Cystic Fibrosis Across the Lifespan -- Sex Differences in Chronic Obstructive Pulmonary Disease -- Sex-Differences in Pulmonary Arterial Hypertension -- Sex and Gender Differences in the Susceptibility to Environmental Exposures -- Respiratory Sex Differences in Response to Smoke Exposure -- Sex Differences in Adaptive Immunity in Chronic Lung Disease -- Network Medicine and Systems Biology Considerations to Understand Sex Differences in Lung Disease -- Sex Differences in Respiratory Infection -- Androgen Excess in Women and the Respiratory System -- Sex Differences in Circadian Biology: Influences on Lung Health and Disease -- Sex Differences in the Coronavirus Disease 2019.
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  • 48
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    Online Resource
    Cham : : Springer International Publishing :
    In: Springer Nature eBook
    Description / Table of Contents: This book emphasizes the necessity of green spaces and landscape planning to achieve a liveable city. It will more specifically enquire on how to reach a better liveability from the current conditions of Lima. This book takes on the one hand classic concepts from urban agronomy as are soil, water and plants, and on the other hand emphasizes the resources, the plant adaptations and the urban ecosystems, according to the context of Lima. Comparisons are also made to landscape concepts from other cities of the word, contemporary methods of urban landscape research are explained in perspectives of agronomy and ecology. The ecological restoration of some natural spaces of Lima are proposed and related to the food security which impacts on the sustainability of the city. Finally, it describes representative Parks of Lima and previous research projects that have allowed to improve the urban landscape. Considering the city's cultural diversity, comparisons to the mountain and rainforest areas are also made.
    Type of Medium: Online Resource
    Pages: XXI, 175 p. 60 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030699055
    Series Statement: Sustainable Development Goals Series,
    Language: English
    Note: Introduction: Definition of sustainable city and public spaces -- Landscape study and methodology -- Botanic for landscapists -- Peruvian gardens -- Park typology and legislation -- Environmental problems -- Urban ecology -- Ecological Restoration.
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  • 49
    In: Springer Nature eBook
    Description / Table of Contents: This book illustrates the importance and significance of bioinformatics in the field of agriculture. It first introduces the basic concepts of bioinformatics, such as homologous sequence and gene function analyses, determination of protein structures, and discusses machine learning applications for an in-depth understanding of the desired genes and proteins based on commonly used bioinformatics software and tools, e.g. BLAST, molecular modelling, molecular-docking and simulations, protein-protein and domain-domain interactions. The book also describes recent advances in the high-throughput analysis of whole genome and transcriptome using next-generation sequencing platforms, and functional proteome studies. It also examines the role of computational biology in understanding and improving the nutrient quality and yield of crops. Lastly, the book explores a comprehensive list of applications of bioinformatics to improve plant yield, biomass, and health, and the challenges involved.
    Type of Medium: Online Resource