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  • 1
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    London : Henry Stewart Talks
    Keywords: Biochemical markers ; Bioinformatics ; Computational Biology ; Biomarkers / analysis ; Computational Biology ; Metabolome ; Metabolomics / methods
    Description / Table of Contents: Contents: Early metabolomics -- Biomarker diagnosis & monitoring -- Metabolomics on a chip -- Omics by numbers -- Cell size vs. metabolite -- Dynamic range of metabolome -- Snapshot metabolomics
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (36 min.) : color, sound).
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  • 2
    Keywords: Active oxygen ; Bioenergetics ; Cellular signal transduction ; Mitochondria ; Hydrogen Peroxide ; Mitochondria / metabolism ; Oxygen / metabolism ; Reactive Oxygen Species / metabolism ; Signal Transduction
    Description / Table of Contents: Contents: Mitochondrial bioenergetics -- Oxygen, its radicals, and oxidative distress vs. oxidative eustress -- Use of H2O2 as a mitokine -- Understanding mitochondrial ROS release -- Sites of ROS production and formation
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (21 min.) : color, sound).
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  • 3
    Keywords: Alzheimer's disease / Epidemiology ; Alzheimer's disease / Genetic aspects ; Alzheimer's disease / Pathology ; Genomics ; Medical genetics ; Alzheimer Disease / epidemiology ; Alzheimer Disease / genetics ; Alzheimer Disease / pathology ; Genome-Wide Association Study ; Genomics ; Risk Factors
    Description / Table of Contents: Contents: Alzheimer's disease (AD): pathology, epidemiology and risk factors -- Genetics of AD: early-onset AD (EOAD) & late-onset AD (LOAD) -- Future genomic studies of AD
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (42 min.) : color, sound).
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  • 4
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Computational Biology ; Mass spectrometry / Data processing ; Nuclear magnetic resonance spectroscopy / Data processing ; Chromatography, Liquid ; Computational Biology ; Gas Chromatography-Mass Spectrometry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry / methods ; Metabolome ; Metabolomics / methods
    Description / Table of Contents: Contents: High mass accuracy/resolution -- Nuclear Magnetic Resonance (NMR) vs. Mass Spectrometry (MS) -- GC-MS (gas chromatography-mass spec) -- LC-MS (Liquid chromatography-mass spec) -- Metabolite identification -- Database search -- Applications of metabolomics & resources
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (26 min.) : color, sound).
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  • 5
    Keywords: Big data ; Cheminformatics ; Drug development / Data processing ; Pharmaceutical chemistry ; Pharmacy informatics ; Chemistry, Pharmaceutical / methods ; Computational Biology / methods ; Databases, Factual ; Drug Discovery / methods ; Pharmaceutical Preparations ; Polypharmacology
    Description / Table of Contents: Contents: Big data criteria in medicinal chemistry -- Data at varying confidence levels -- Promiscuity and polypharmacology -- Compound promiscuity analysis in light of big data criteria -- Promiscuity of screening hits -- Promiscuity across major target families -- Promiscuity of kinase inhibitors
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 6
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    London : Henry Stewart Talks
    Keywords: Antiasthmatic agents ; Asthma in children ; Asthma / Chemotherapy ; Anti-Asthmatic Agents / therapeutic use ; Asthma / complications ; Asthma / Diagnosis ; Asthma / drug therapy ; Child ; Drug Resistance ; Pediatric Obesity / complications ; Phenotype ; Severity of Illness Index ; Steroids / therapeutic use
    Description / Table of Contents: Contents: Examples of representative airway diseases in children -- Updating our view about severe asthma -- Review of novel mechanistic data in true severe therapy-resistant asthma -- Different phenotypes of "steroid resistant asthma" and their management
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (42 min.) : color, sound).
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  • 7
    Keywords: Active oxygen ; Bioenergetics ; Cellular signal transduction ; Mitochondria ; Cell Communication ; Hydrogen Peroxide ; Mitochondria / metabolism ; Oxygen / metabolism ; Reactive Oxygen Species / metabolism ; Signal Transduction
    Description / Table of Contents: Contents: Controlling mitochondrial ROS production (proton leaks, super complex assemblies, and redox switches) -- Implications of redox switches in controlling mitochondrial ROS signalling
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (32 min.) : color, sound).
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  • 8
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    London : Henry Stewart Talks
    Keywords: Complement (Immunology) ; Molecular microbiology ; Natural immunity ; Viruses ; CD59 Antigens / immunology ; Complement System Proteins / immunology ; Complement System Proteins / physiology ; Immune System / physiology ; Molecular Mimicry ; Receptors, Complement ; Vaccinia virus / physiology ; Viral Proteins / immunology ; Virus Physiological Phenomena ; Viruses / immunology
    Description / Table of Contents: Contents: Recognition of viruses by the complement system -- Role of complement in antiviral immunity -- Complement subversion by viruses: molecular mimicry, molecular piracy, use of complement receptors and regulators for cellular entry, and modulation of complement protein expression
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (20 min.) : color, sound).
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  • 9
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    London : Henry Stewart Talks
    Keywords: Messenger RNA ; Mitochondria ; Proteins / Synthesis ; Ribosomes ; Transfer RNA ; Genetic Code ; Mammals ; Mitochondrial Membranes / metabolism ; Mitochondrial Proteins / biosynthesis ; Mitochondrial Proteins ; Models, Biological ; Peptide Elongation Factors ; Peptide Initiation Factors ; Protein Biosynthesis ; Ribosomes ; RNA, Messenger / metabolism ; RNA, Ribosomal / metabolism ; RNA, Transfer / metabolism
    Description / Table of Contents: Contents: General features of mammalian mitochondrial translation: the genetic code, tRNAs, mRNAs and ribosomes -- Initiation of translation: current working model, properties of the initiation factors -- Elongation of translation: current working model, properties of the elongation factors -- Role of the membrane and possible translational activators -- Major remaining questions
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (37 min.) : color, sound).
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  • 10
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    London : Henry Stewart Talks
    Keywords: Active oxygen ; Aging / Physiological aspects ; Biological models ; Mitochondria ; Mitochondrial pathology ; Oxidative Stress ; Aging / physiology ; Caloric Restriction ; DNA, Mitochondrial ; Energy Metabolism ; Free Radicals ; Mitochondria / metabolism ; Mitochondria / pathology ; Models, Biological ; Mutation ; Oxidative Stress ; Phenotype ; Reactive Oxygen Species
    Description / Table of Contents: Contents: Mitochondria function/dysfunction and related outcomes -- Metabolic rate theory of aging -- Beneficial effects of caloric restriction -- ROS production and oxidative stress effect on aging -- Free radical theory of aging -- Mitochondrial DNA mutations phenotypes
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 11
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    London : Henry Stewart Talks
    Keywords: Genetic disorders ; Methemoglobinemia ; Cytochrome-B(5) Reductase / deficiency ; Diagnosis, Differential ; Methemoglobinemia / congenital ; Methemoglobinemia / diagnosis ; Methemoglobinemia / therapy ; Mutation ; Phenotype
    Description / Table of Contents: Contents: Formation of methemoglobinemia -- Review of methemoglobinemias types -- Cytochrome b5 reductase (Cytb5 R) -- Mutations and clinical phenotypes of Cytb5 R deficiency -- Differential diagnosis from other methemoglobinemias -- Therapy of methemoglobinemia
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (26 min.) : color, sound).
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  • 12
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    London : Henry Stewart Talks
    Keywords: Cell Death ; Mitochondria ; Mitochondrial pathology ; Autophagy ; Mitochondria / metabolism ; Mitochondria / physiology ; Mitochondrial Degradation ; Mitochondrial Dynamics
    Description / Table of Contents: Contents: Mitochondrial function and dysfunction -- Mitochondrial quality control and degradation -- Autophagy -- Mitophagy, the mitochondria-specific autophagy pathway -- Mechanisms and molecules involved in Mitophagy -- Physiological and pathophysiological roles of Mitophagy
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 13
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    London : Henry Stewart Talks
    Keywords: Cancer / Diagnosis ; Cancer / Genetic aspects ; Cancer / Treatment ; MicroRNA ; Non-coding RNA ; Tumor markers ; Biomarkers, Tumor ; Cell Transformation, Neoplastic / genetics ; MicroRNAs ; Neoplasms / diagnosis ; Neoplasms / genetics ; Neoplasms / therapy ; RNA, Long Noncoding ; RNA, Untranslated
    Description / Table of Contents: Contents: Types of non-coding RNAs -- Role of microRNAs and long non-coding RNAs in cancers -- Recent advances in strategies to utilize miRNAs and lncRNAs as biomarkers in cancer -- miRNAs and lncRNAs are currently in clinical development as diagnostic, prognostic and predictive biomarkers for cancer -- Recent advances in strategies to utilize miRNAs and lncRNAs as therapeutic targets in cancer
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 14
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    London : Henry Stewart Talks
    Keywords: Biological Transport ; Mitochondria ; Mitochondrial pathology ; Proteins / Conformation ; Adenosine Diphosphate / metabolism ; Adenosine triphosphate / Metabolism ; Binding Sites ; Biological Transport, Active ; Calcium / metabolism ; Carrier Proteins ; Humans ; Mitochondria / metabolism ; Mitochondrial ADP, ATP Translocases ; Mitochondrial Diseases ; Mitochondrial Membrane Transport Proteins ; Mitochondrial Proteins ; Protein Conformation
    Description / Table of Contents: Contents: The involvement of salt bridge networks in the transport mechanism -- Conformational changes in transport -- Involvement of mitochondrial carriers in human diseases -- Calcium regulation of transport
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (46 min.) : color, sound).
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  • 15
    Keywords: Dental anthropology ; Forensic anthropology ; Forensic dentistry ; Gene Flow ; Human population genetics ; Teeth / Anatomy ; Anthropology, Physical / methods ; Forensic Anthropology / methods ; Forensic Dentistry / methods ; Gene Flow ; Paleodontology / methods ; Population Groups ; Tooth / anatomy & histology
    Description / Table of Contents: Contents: Evolutionary mechanisms underlying variation in dental morphology -- Dental morphology and population history -- Using combination of traits to identify ancestry of individuals in a forensic context
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (33 min.) : color, sound).
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  • 16
    Keywords: Dental anthropology ; Forensic dentistry ; Human population genetics ; Teeth / Anatomy ; Anthropology, Physical ; Forensic dentistry ; Paleodontology ; Population Groups ; Tooth Crown / anatomy & histology ; Tooth Root / anatomy & histology ; Tooth / anatomy & histology
    Description / Table of Contents: Contents: The importance of teeth in anthropology -- Dental morphology -- Nonmetric traits with strong genetic basis -- Traits showing patterned geographic variation on world scale
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 17
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    London : Henry Stewart Talks
    Keywords: Antiphospholipid syndrome / Chemotherapy ; Cardiovascular disease ; Chronic Pain ; Clinical Trials ; Drug development ; Musculoskeletal system / Diseases ; Rheumatism / Chemotherapy ; Systemic lupus erythematosus / Chemotherapy ; Antiphospholipid Syndrome / drug therapy ; Cardiovascular Diseases ; Chronic Pain / drug therapy ; Clinical Trials as Topic ; Drug Discovery ; Drug-Related Side Effects and Adverse Reactions ; Lupus erythematosus, Systemic / drug therapy ; Musculoskeletal Pain / drug therapy ; Rheumatic Diseases / drug therapy ; Risk Factors
    Description / Table of Contents: Contents: Current status of and challenges in the research into therapeutic interventions for antiphospholipid syndrome (APS) -- The hurdles pharmaceutical companies are facing on their way to developing APS treatments -- Dealing with increased cardiovascular risks in patients with rheumatic autoimmune diseases -- Challenges in lupus clinical trials -- Current challenges in developing chronic musculoskeletal pain treatments
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (29 min.))
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  • 18
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Biological models ; Computational Biology ; Genomics ; Systems Biology ; Computational Biology ; Metabolic Networks and Pathways ; Metabolomics ; Systems Biology / methods
    Description / Table of Contents: Contents: Recent approaches in system biology and modeling -- Different compartment and building of genome scale metabolic network models -- Using system biology markup languages (SBML) to represent metabolic models -- Main concepts in SBML model building
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (23 min.) : color, sound).
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  • 19
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    London : Henry Stewart Talks
    Keywords: Complement (Immunology) ; Kidneys / Transplantation ; Complement Activation ; Complement C3a ; Complement C5a ; Complement C5b ; Complement System Proteins / immunology ; Graft Rejection / immunology ; Kidney Transplantation ; Kidney Tubules / injuries ; Transplantation Immunology
    Description / Table of Contents: Contents: Important barriers to successful transplantation -- Tissue compartments affected by injury -- Contribution of local synthesis of complement -- C5a and C5b-9 dependent ischaemic renal tubule injury -- Priming of the T cell response by C3a, C5a -- Triggering complement activation on hypoxic cells
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (51 min.) : color, sound).
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  • 20
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    London : Henry Stewart Talks
    Keywords: Adaptive sampling (Statistics) ; Clinical trials / Design ; Clinical trials / Statistical methods ; Drug development ; Research / Design ; Bayes Theorem ; Biostatistics / methods ; Clinical Protocols ; Clinical Trials as Topic / methods ; Clinical Trials as Topic / statistics & numerical data ; Computer Simulation ; Decision Support Techniques ; Dose-Response Relationship, Drug ; Drug Dosage Calculations ; Drug-Related Side Effects and Adverse Reactions ; Models, Statistical ; Research Design / methods ; Safety ; Sample Size
    Description / Table of Contents: Contents: Practical guidance on implementing adaptive designs in early-phase clinical trials -- Essential protocol information that leads to acceptance of the design and directs implementation -- Issues that need to be considered and addressed prior to starting an adaptive design -- Examples & general check list on designing and implementing early-phase adaptive designs
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (47 min.) : color, sound).
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  • 21
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    London : Henry Stewart Talks
    Keywords: Anti-vaccination movement / European Union countries ; Anti-vaccination movement / Great Britain ; Anti-vaccination movement / United States ; Communication in public health ; Health attitudes ; Vaccination of children / Complications ; Vaccines / Health aspects ; Anti-Vaccination Movement / trends ; Health knowledge, Attitudes, Practice ; Health Promotion ; Social media ; Vaccination / adverse effects ; Vaccination / trends
    Description / Table of Contents: Contents: Anti-vaccination movements in the US and the EU -- The impact of vaccine opposition on the numbers of measles and influenza cases -- The influence of public and social media on pro/anti-vaccines debate -- Lack of public’s trust in the pharmaceutical industry and regulatory agencies in the US and the EU -- The demographics of anti-vaccinators in the US and the UK -- Challenges in communicating the safety and importance of vaccine to the public
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (27 min.)).
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  • 22
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    London : Henry Stewart Talks
    Keywords: Aging / Physiological aspects ; Cell metabolism ; Cellular signal transduction ; Exercise / Physiological aspects ; Mitochondria ; Muscles / Physiology ; Adaptation, Physiological ; Aging / physiology ; Exercise / physiology ; Mitochondria, Muscle / metabolism ; Mitochondria, Muscle / physiology ; Muscle Fibers, Skeletal ; Muscle, Skeletal ; Organelle Biogenesis ; Signal Transduction
    Description / Table of Contents: Contents: Introduction to skeletal muscle fiber types -- Mitochondrial morphology in muscle fiber types -- Mitochondrial adaptations to exercise training -- Mitochondrial content, physical activity & aging -- Signaling to mitochondrial biogenesis -- Endurance performance & mitochondria content
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (28 min.) : color, sound).
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  • 23
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Computational Biology ; Experimental design ; Information organization ; Information retrieval ; Information visualization ; Metabolites ; Chromatography, Liquid ; Computational Biology ; Data mining ; Databases, Factual ; Gas Chromatography-Mass Spectrometry ; Information Storage and Retrieval / methods ; Metabolomics / methods ; Research Design
    Description / Table of Contents: Contents: Pre-processing data analysis -- Metabolomics bottleneck & the "cocktail party problem" -- From raw data to metabolites IDs -- Challenges in GC/MS & LC/MS -- Metabolic annotation examples -- LC/MS workflow -- Searching databases -- Hypothesis & experimental validation -- "Static", "Dynamic" & "Integrated" pictures of metabolomics
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (30 min.) : color, sound).
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  • 24
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    London : Henry Stewart Talks
    Keywords: Aging / Genetic aspects ; Cardiovascular system / Diseases ; Disease susceptibility / Genetic aspects ; Telomerase ; Telomere ; Age Factors ; Aging / genetics ; Cardiovascular Diseases / genetics ; Genetic Predisposition to Disease / genetics ; Leukocytes / metabolism ; Risk Factors ; Telomerase / genetics ; Telomere / genetics
    Description / Table of Contents: Contents: Vertebrate telomere structure and telomerase -- Telomeres and monogenic disease -- Telomeres and ageing -- Factors that affect leukocyte telomere length (LTL) -- Telomere length and stressful life events -- Telomeres and cardiovascular disease risk -- Common genetic variants associated with LTL -- A causal role for LTL in CVD: evidence and potential mechanisms
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (43 min.) : color, sound).
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  • 25
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    London : Henry Stewart Talks
    Keywords: Adaptive sampling (Statistics) ; Clinical trials / Design ; Clinical trials / Statistical methods ; Research / Design ; Clinical Trials, Phase II as Topic / methods ; Randomized Controlled Trials as Topic / methods ; Research Design
    Description / Table of Contents: Contents: Frequentist methods -- Non-adaptive trial design -- Single stage single outcome design -- Randomized dose-ranging design -- Controlled titration design -- Adaptive trial designs -- Single outcome multi-stage designs -- Multiple outcomes multi-stage design
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (34 min.) : color, sound).
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  • 26
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    London : Henry Stewart Talks
    Keywords: Dry eye syndromes ; Tears ; Dry Eye Syndromes / diagnosis ; Dry Eye Syndromes / epidemiology ; Dry Eye Syndromes / therapy ; Tears / physiology
    Description / Table of Contents: Contents: Function of the tear film -- TFOS DEWS II report -- Definition and classification of dry eye disease -- Epidemiology of dry eye disease -- Pathophysiology of dry eye disease -- Available diagnostic methodology -- Management and Therapy of dry eye disease
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (43 min.) : color, sound).
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  • 27
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    London : Henry Stewart Talks
    Keywords: Chronic renal failure / Prevention ; Exercise / Health aspects ; Health promotion / Technological innovations ; Information technology / Health aspects ; Medical technology ; Medical telematics ; Personalized medicine ; Polysomnography ; Wearable computers ; Disease Management ; Exercise / physiology ; Kidney Failure, Chronic / prevention & control ; Polysomnography / methods ; Precision Medicine ; Renal Insufficiency, Chronic / prevention & control ; Wearable Electronic Devices
    Description / Table of Contents: Contents: Defining pervasive sensing -- Example of use of wearable technology in medicine -- Accuracy of wearable technologies -- Physical activity's role in improved health outcomes -- Physical activity and sleep monitoring in ESRD patients -- The effects of environment on physical activity levels -- Role of environment in precision medicine
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (28 min.) : color, sound).
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  • 28
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    London : Henry Stewart Talks
    Keywords: Embryology ; Gametogenesis ; Mitochondria ; Oogenesis ; Aging / physiology ; Cumulus Cells ; DNA, Mitochondrial ; Embryonic Development ; Mitochondria ; Oocytes ; Oogenesis ; Reproduction / genetics
    Description / Table of Contents: Contents: Mitochondria and embryogenesis -- Mitochondria and ovarian ageing -- The role of cumulus granulosa cells -- Mitochondrial genetics and fertility -- Targeting mitochondria to improve oocyte quality
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (30 min.) : color, sound).
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  • 29
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    London : Henry Stewart Talks
    Keywords: Systemic scleroderma ; Biomarkers ; Fibrosis ; Immune System / pathology ; Scleroderma, Systemic / classification ; Scleroderma, Systemic / pathology ; Scleroderma, Systemic / therapy
    Description / Table of Contents: Contents: Complications associated with systemic sclerosis -- The disease process in systemic sclerosis -- Disease pathogenesis -- Humoral immune system alterations -- Fibrosis -- Molecular mechanisms in systemic sclerosis -- Systemic sclerosis classification criteria -- Biomarkers -- The modified Rodnan Skin Score -- Skin thickness progression rate -- Effectiveness of therapies -- New targeted therapies for SSc fibrosis
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (36 min.) : color, sound).
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  • 30
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    London : Henry Stewart Talks
    Keywords: Cervix uteri / Cancer ; Clinical Trials ; Papillomavirus diseases / Vaccination ; Papillomaviruses ; Antibody Formation ; Immunization Programs ; Papillomaviridae / genetics ; Papillomavirus Infections / epidemiology ; Papillomavirus Infections / prevention & control ; Papillomavirus Vaccines ; Randomized Controlled Trials as Topic ; Secondary Prevention ; Uterine Cervical Neoplasms / epidemiology ; Uterine Cervical Neoplasms / etiology ; Uterine Cervical Neoplasms / prevention & control ; Vaccination / trends ; Viral Vaccines
    Description / Table of Contents: Contents: Human papillomavirus (HPV) lifecycle -- Cervical HPV infection and progression to cancer -- Primary and secondary prevention method -- Prophylactic HPV vaccines -- Efficacy and durability of HPV viral-like particles (VPL) vaccines -- The potential of a one-dose vaccination program -- Randomized trials -- Vaccine protection against pre-malignant lesions -- Vaccine safety record & effectiveness -- HPV vaccine uptake -- Antibody response -- Increasing vaccine use
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (45 min.) : color, sound).
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  • 31
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    London : Henry Stewart Talks
    Keywords: Cell Death ; Cellular signal transduction ; Mitochondria ; Protein Kinases ; Adaptor Proteins, Signal Transducing ; Autophagy / physiology ; Mitochondria / metabolism ; Mitochondrial Degradation ; Protein Kinases / metabolism ; Salmonella ; Sequestosome-1 Protein
    Description / Table of Contents: Contents: Selective autophagy mechanisms and importance for health -- Principles of action of cargo receptors -- p62 and aggrephagy -- LIR motifs -- Salmonella and xenophagy -- Mitophagy -- Erphagy
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 32
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    London : Henry Stewart Talks
    Keywords: Antineoplastic agents / Development ; Cellular signal transduction ; Drug development ; Protein Kinases ; Yeast ; ACA-28 cpd ; Antineoplastic Agents / pharmacology ; Drug Discovery ; Extracellular Signal-Regulated MAP Kinases ; MAP Kinase Signaling System / physiology ; Melanoma / drug therapy ; Saccharomyces cerevisiae / drug effects ; Signal Transduction / drug effects
    Description / Table of Contents: Contents: MAPK signalling and its relevance to cancer therapy -- The discovery of ACA-28 -- The use of yeast within drug discovery -- Effect of ACA-28 on the apoptosis of cancer cells -- Implications of ACA-28 in cancer therapeutics
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (23 min.) : color, sound).
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  • 33
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    London : Henry Stewart Talks
    Keywords: Cell Death ; Lysosomes ; Nervous system / Degeneration ; Ataxin-3 ; Autophagy / physiology ; Lysosomes / metabolism ; Neurodegenerative Diseases / metabolism ; Neurodegenerative Diseases / pathology ; Neurodegenerative Diseases / therapy ; Signal Transduction / physiology
    Description / Table of Contents: Contents: Autophagy-lysosome pathway -- Autophagy signaling (canonical & non-canonical) -- Neurodegenerative diseases impairing autophagy -- Exploring pathogenic mechanism -- Ataxin 3 & autophagy -- Autophagy and neurodegeneration
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (39 min.) : color, sound).
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  • 34
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    London : Henry Stewart Talks
    Keywords: Arthritis ; Gout ; Joints / Diseases ; Pain / Treatment ; Acute Disease ; Arthralgia / diagnosis ; Arthralgia / drug therapy ; Arthritis / diagnosis ; Arthritis / drug therapy ; Diagnosis, Differential ; Gout / diagnosis ; Gout / drug therapy ; Pain Management
    Description / Table of Contents: Contents: Comparison of arthralgia and arthritis -- NO PADS acronym for diagnosis -- Disease distribution -- Acute monoarthritis differential diagnosis -- A practical treatment process -- Gout management -- Common uric-acid lowering medications
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (48 min.) : color, sound).
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  • 35
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    London : Henry Stewart Talks
    Keywords: Autoimmune Diseases ; Sjogren's Syndrome ; Autoimmunity ; Lymphoma ; Risk Factors ; Sjogren's Syndrome / immunology ; Sjogren's Syndrome / pathology ; Sjogren's Syndrome / therapy
    Description / Table of Contents: Contents: Introduction to Sjögren's syndrome -- Humoral and cellular autoimmune responses in Sjögren's syndrome -- Description of heterogenic clinical features of disease -- Pathogenetic/immunopathologic aspects and associations with clinical phenotypes -- The need for precise therapeutic approaches -- Development and features of lymphoma in Sjögren's syndrome -- Risk factors for development of severe disease -- Biomarkers for disease severity, outcome and lymphoma
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 36
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    London : Henry Stewart Talks
    Keywords: AIDS (Disease) / Prevention ; Antiretroviral agents ; HIV infections / Immunological aspects ; HIV infections / Treatment ; Acquired Immunodeficiency Syndrome / prevention & control ; Anti-HIV Agents / therapeutic use ; Anti-Retroviral Agents / therapeutic use ; HIV Infections / drug therapy ; HIV Infections / immunology ; HIV Infections / virology ; Immunity, Innate ; Research Design ; Viral Load
    Description / Table of Contents: Contents: The disease process of HIV -- The rationale for a cure in 2018 -- Conceptual overview of HIV cure research -- Leading questions in cure research -- Stages in cure-directed studies -- Examples of cure-directed study designs
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (38 min.) : color, sound).
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  • 37
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    London : Henry Stewart Talks
    Keywords: Developmental genetics ; Endometriosis ; Endometriosis / genetics ; Endometriosis / pathology ; Epigenesis, Genetic ; Genomics
    Description / Table of Contents: Contents: Basic theories & hypotheses on endometriosis -- A systems genetic view of endometriosis -- The junctional zone and its association with endometriosis -- Genomics of endometriosis -- The developmental genetic program of endometriosis (EMDP) -- Critical periods (CP) I, II, and III of EMDP -- Implications of the EMDP hypothesis -- Validating the EMDP hypothesis
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (20 min.) : color, sound).
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  • 38
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    London : Henry Stewart Talks
    Keywords: Drug Delivery Systems ; Nanobiotechnology ; Nanostructured materials ; Polymers / Biotechnology ; Drug Carriers / administration & dosage ; Drug Carriers / chemistry ; Drug Delivery Systems / methods ; Nanomedicine / methods ; Nanostructures / administration & dosage ; Polyethylene Glycols ; Polymers / administration & dosage ; Polymers / chemistry ; Technology, Pharmaceutical / methods
    Description / Table of Contents: Contents: Definition and introduction of polymers as nanocarriers -- Mechanisms and triggers for controlled drug delivery -- Biological fate of polymeric nanocarriers -- The use of polymer-drug conjugates for anticancer therapy -- Examples of thermoresponsive nanogels and polymeric nanoparticles for hair follicle penetration for topical drug delivery
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (47 min.) : color, sound).
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  • 39
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    London : Henry Stewart Talks
    Keywords: Blood-Brain Barrier ; Brain / Diseases ; Drug Delivery Systems ; Nanobiotechnology ; Nanomedicine ; Alzheimer Disease / drug therapy ; Blood-Brain Barrier / drug effects ; Blood-Brain Barrier / physiopathology ; Brain Diseases / drug therapy ; Drug Delivery Systems / methods ; Nanomedicine / methods ; Nanostructures / therapeutic use ; Nanotechnology ; Neurology / trends
    Description / Table of Contents: Contents: The Blood-Brain Barrier in healthy and diseased state -- Planning a nano-4-neuro -- Strategies for Blood-Brain Barrier crossing with nanotechnology -- Technological issues -- What we learn and what to do in NPs for CNS -- Exploitation of endogenous/exogenous pathways -- Proofs of concept and pharmacological evidences -- The case of Alzheimer's Disease: analysis of nanomedicine applications
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (50 min.) : color, sound).
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  • 40
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    London : Henry Stewart Talks
    Keywords: Complement (Immunology) ; Systemic lupus erythematosus ; Complement Activation / immunology ; Complement C1q / immunology ; Complement System Proteins ; eculizumab ; Lupus Erythematosus, Systemic / immunology ; Lupus Erythematosus, Systemic / therapy
    Description / Table of Contents: Contents: Measurement of complement in lupus -- The role of complement in lupus pathogenesis -- Anti-C1q antibodies (pathogenic or epiphenomenon?) -- Complement therapy in lupus
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (42 min.) : color, sound).
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  • 41
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    London : Henry Stewart Talks
    Keywords: Arbovirus infections ; Arboviruses ; Dengue ; Drug development ; Mosquitoes / Control ; Vaccines / Development ; Zika virus ; Arbovirus infections ; Arboviruses ; Chikungunya Fever ; Chikungunya virus ; Dengue Virus ; Dengue ; Mosquito Control ; Vaccination ; Vaccines ; Virus Replication ; Zika Virus Infection ; Zika virus
    Description / Table of Contents: Contents: Arbovirus classification -- Flaviviruses -- Dengue virus transmission -- Antibody mediated enhancement -- Mosquito control -- Dengue infections -- Global burden of dengue -- Dengue virus replication and polyprotein processing -- Innate immune evasion by dengue virus -- Dengue vaccine development -- Zika virus and disease -- Chikungunya epidemiology -- Chikungunya virus
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (36 min.) : color, sound).
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  • 42
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    London : Henry Stewart Talks
    Keywords: Antiphospholipid syndrome / Chemotherapy ; Antiphospholipid syndrome / Diagnosis ; Drug development ; Systemic lupus erythematosus / Chemotherapy ; Systemic lupus erythematosus / Diagnosis ; Antiphospholipid Syndrome / drug therapy ; Antiphospholipid Syndrome / etiology ; Antiphospholipid Syndrome / pathology ; Drug Discovery ; Lupus erythematosus, Systemic / drug therapy ; Lupus Erythematosus, Systemic / etiology ; Lupus erythematosus, Systemic / pathology
    Description / Table of Contents: Contents: Genetics vs. environmental triggers in antiphospholipid syndrome and Lupus -- Current challenges in diagnosis and the limitation of available treatments -- Open questions with regard to the underlying mechanisms of antiphospholipid syndrome and Lupus -- Potential directions in the development of diagnostic tools and therapeutic approaches
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (19 min.))
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  • 43
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    London : Henry Stewart Talks
    Keywords: Antineoplastic Agents ; Cancer / Chemotherapy ; Cancer / Treatment ; Cell Death ; Chronic myeloid leukemia ; Antineoplastic Agents / therapeutic use ; Autophagy / drug effects ; Autophagy / physiology ; Hematopoiesis / physiology ; Hematopoietic Stem Cells / drug effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy ; Neoplasms / drug therapy ; Neoplastic Stem Cells / drug effects
    Description / Table of Contents: Contents: History of autophagy -- Types of autophagy -- Methods for monitoring autophagy -- Autophagy and cancer -- The role of autophagy in haematopoiesis -- Autophagy & chronic myeloid leukaemia (CML) -- Future autophagy inhibitors
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (32 min.) : color, sound).
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  • 44
    Keywords: Autoimmune Diseases ; Behavior disorders in children / Diagnosis ; Behavior disorders in children / Etiology ; Behavior disorders in children / Treatment ; Nervous system / Diseases ; Pediatric neurology ; Streptococcal infections / Complications ; Autoimmune Diseases / microbiology ; Child Behavior Disorders / diagnosis ; Child Behavior Disorders / etiology ; Child Behavior Disorders / therapy ; Child ; Nervous System Diseases / immunology ; Streptococcal infections / Complications ; Streptococcal Infections / immunology ; Streptococcus pyogenes / immunology
    Description / Table of Contents: Contents: The effect of Group A streptococcal infections on the behaviour of children -- The problem of diagnosis in PANDAS -- Potential mechanisms underlying PANDAS and the role of the immune system -- Current therapeutic interventions and potential future ones -- The importance of developing better diagnostic tools
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (25 min.))
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  • 45
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    London : Henry Stewart Talks
    Keywords: Biological Transport ; Mitochondria ; Adenosine Diphosphate / metabolism ; Adenosine triphosphate / Metabolism ; Binding Sites ; Biological Transport, Active ; Carrier Proteins ; Mitochondria / metabolism ; Mitochondrial ADP, ATP Translocases ; Mitochondrial Membrane Transport Proteins ; Mitochondrial Proteins / chemistry ; Mitochondrial Proteins / metabolism
    Description / Table of Contents: Contents: Mitochondria in the human cell -- Role of mitochondrial carriers in human metabolism -- Sequence and structure of mitochondrial carriers -- The central substrate binding site -- The involvement of salt bridge networks in the transport mechanism
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (61 min.) : color, sound).
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  • 46
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    London : Henry Stewart Talks
    Keywords: Genetic engineering / Law and legislation ; Genetic engineering / Methodology ; Genetic engineering / Research ; Gene Drive Technology / ethics ; Gene Drive Technology / legislation & jurisprudence ; Gene Drive Technology / methods
    Description / Table of Contents: Contents: Best practice guidance -- Safety and efficacy testing -- Regulatory precedents and planning -- Transparency and accountability -- Effective engagement -- Research partnerships -- Capacity strengthening
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (32 min.) : color, sound).
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  • 47
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Communication of technical information ; Computational Biology ; Information organization ; Information retrieval ; Metabolites ; Computational Biology / methods ; Databases, Factual ; Information Dissemination / methods ; Information Storage and Retrieval / methods ; Metabolomics ; Metadata ; Quality Control ; Reference Standards
    Description / Table of Contents: Contents: Current state of data sharing and exchange standards -- Making efficient use of data for metabolomics -- Metabolomics standard initiative -- Data sharing repositories -- Metabolite annotation/identification -- Capturing metadata -- Metabolomics identification -- Quality control in metabolomics -- Journals for metabolomics data-sharing and reuse
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (38 min.) : color, sound).
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  • 48
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    London : Henry Stewart Talks
    Keywords: Antineoplastic Agents ; Cancer / Chemotherapy ; Drugs / metabolism ; Enzymes ; Personalized medicine ; Antineoplastic Agents / pharmacology ; Drug Delivery Systems ; Drug Resistance ; Enzymes / metabolism ; Neoplasms / drug therapy ; Pharmaceutical Preparations / metabolism ; Precision Medicine
    Description / Table of Contents: Contents: Drug metabolism -- Classification of drug metabolizing enzymes (DMEs) -- Clinical significance of DMEs in cancer therapeutics -- Drug delivery -- Drug resistance -- Interindividual variability and precision oncology
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (26 min.) : color, sound).
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  • 49
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    London : Henry Stewart Talks
    Keywords: Clinical trials / Design ; Clinical trials / Statistical methods ; Drug development / Statistical methods ; Drugs / Dose-response relationship ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Drug Dosage Calculations ; Models, Statistical ; Patient Selection ; Research Design / methods ; Research Design / statistics & numerical data
    Description / Table of Contents: Contents: Review of traditional dose-finding designs -- 2-group dose-finding trials -- 2-sample CRM -- Shift model -- Matrix order -- Hwang-Peddada estimation
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (26 min.) : color, sound).
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  • 50
    Keywords: Complement (Immunology) ; Medical genetics ; Retinal degeneration / Age factors ; Retinal degeneration / Genetic aspects ; Complement Activation ; Complement C3 Convertase, Alternative Pathway ; Complement Pathway, Alternative ; Genetic Testing ; Genotype ; Macular Degeneration / genetics ; Macular Degeneration / immunology ; Phenotype
    Description / Table of Contents: Contents: Inherited complement-related diseases -- Complement genetic variability -- Genotype-phenotype correlations -- Complement dysregulation in age-related macular degeneration (AMD) -- The complotype -- Complex rearrangements of complement genes -- Complement genetic testing
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (49 min.) : color, sound).
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  • 51
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    London : Henry Stewart Talks
    Keywords: Cancer / Chemotherapy ; Cancer / Treatment ; Oncology ; Drug-Related Side Effects and Adverse Reactions ; Neoplasms / drug therapy ; Neoplasms / surgery ; Neoplasms / therapy ; Palliative Care ; Radiotherapy
    Description / Table of Contents: Contents: Cancer basics -- Staging -- Treating cancer -- Surgery -- Radiation -- Chemotherapy -- Log-Kill Hypothesis -- Hormone therapy -- Targeted therapy -- A companion diagnostic -- Treatment resistance -- The tumour genome -- Reducing side effects -- Palliative care
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (38 min.) : color, sound).
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  • 52
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    London : Henry Stewart Talks
    Keywords: Clinical trials / Statistical methods ; Drug development / Statistical methods ; Drugs / Dose-response relationship ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Drug Dosage Calculations ; Models, Statistical ; Patient Selection ; Research Design / methods ; Research Design / statistics & numerical data
    Description / Table of Contents: Contents: More than two ordered groups -- Completely ordered groups -- Partially ordered groups -- Methods for ordered groups -- Dose allocations
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (20 min.) : color, sound).
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  • 53