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  • 1
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    London : Henry Stewart Talks
    Keywords: Child mental health services / Kurdistan ; Child mental health services / Sweden ; Child mental health / Kurdistan ; Child psychiatry / Kurdistan ; Child ; Mental Disorders ; Mental Health Services ; Stress Disorders, Post-Traumatic
    Description / Table of Contents: Contents: Child mental health definition -- Multidisciplinary scientific field -- Introducing for the first time in Kurdistan in 1991 -- Collaboration with Sweden -- Identifying cultural protecting and risk factors -- Increasing needs following the increasing public awareness -- Research results leading to academic unit establishment -- Building up local competence at three levels -- Service systems including governmental and private sectors
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (20 min.) : color, sound).
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  • 2
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    London : Henry Stewart Talks
    Keywords: Speech therapy for children ; Stuttering in children / Treatment ; Child ; Stuttering / prevention & control ; Stuttering / therapy
    Description / Table of Contents: Contents: Treatment of stuttering during the preschool years -- Why treat early stuttering? -- Two different types of treatment -- Clinical trials -- Advantages and disadvantages of two types of treatment -- The future for the field
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (19 min.) : color, sound).
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  • 3
    Keywords: Active oxygen ; Bioenergetics ; Cellular signal transduction ; Mitochondria ; Hydrogen Peroxide ; Mitochondria / metabolism ; Oxygen / metabolism ; Reactive Oxygen Species / metabolism ; Signal Transduction
    Description / Table of Contents: Contents: Mitochondrial bioenergetics -- Oxygen, its radicals, and oxidative distress vs. oxidative eustress -- Use of H2O2 as a mitokine -- Understanding mitochondrial ROS release -- Sites of ROS production and formation
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (21 min.) : color, sound).
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  • 4
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    London : Henry Stewart Talks
    Keywords: Cancer / Diagnosis ; Cancer / Genetic aspects ; Cancer / Treatment ; MicroRNA ; Non-coding RNA ; Tumor markers ; Biomarkers, Tumor ; Cell Transformation, Neoplastic / genetics ; MicroRNAs ; Neoplasms / diagnosis ; Neoplasms / genetics ; Neoplasms / therapy ; RNA, Long Noncoding ; RNA, Untranslated
    Description / Table of Contents: Contents: Types of non-coding RNAs -- Role of microRNAs and long non-coding RNAs in cancers -- Recent advances in strategies to utilize miRNAs and lncRNAs as biomarkers in cancer -- miRNAs and lncRNAs are currently in clinical development as diagnostic, prognostic and predictive biomarkers for cancer -- Recent advances in strategies to utilize miRNAs and lncRNAs as therapeutic targets in cancer
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 5
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    London : Henry Stewart Talks
    Keywords: Active oxygen ; Biological Transport ; Cellular signal transduction ; Mitochondria ; Mitochondrial pathology ; Electron Transport / physiology ; Hydrogen Peroxide / antagonists & inhibitors ; Mitochondria / metabolism ; Mitochondria / pathology ; Mitochondria / physiology ; Mitochondrial Proteins / metabolism ; Oxidative Phosphorylation ; Reactive Oxygen Species ; Signal Transduction ; Superoxides / antagonists & inhibitors
    Description / Table of Contents: Contents: Suppressors of electron leaks (SELs) -- Identification of SELs for various sites -- Mitochondrial ROS in signaling and disease -- Some biological effects of SELs -- Comparisons between SELs -- SELs as novel tools to diagnose and modify ROS signaling and damage
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (22 min.) : color, sound).
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  • 6
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    London : Henry Stewart Talks
    Keywords: Antineoplastic Agents ; Cancer / Treatment ; Drug development ; Viruses / Therapeutic use ; Antibodies, Neutralizing ; Antineoplastic Agents ; Biological Therapy ; Drug Discovery ; Measles virus ; Neoplasms / therapy ; Oncolytic Virotherapy ; Oncolytic Viruses ; Virus Replication
    Description / Table of Contents: Contents: Modified viruses as friends -- Most licensed vaccines are live-attenuated viruses -- Natural oncolytic properties of viruses -- Preferential replication, efficient tumor access -- Clinical trials with oncolytic viruses -- Licensed therapeutics -- Added oncolytic properties -- Targeting: entry and post-entry -- Arming strategies -- Shielding from neutralizing antibodies -- Monitoring oncolytic virus replication in tumors -- From bench to clinic: the measles paradigm
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (30 min.) : color, sound).
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  • 7
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    London : Henry Stewart Talks
    Keywords: Biological Transport ; Mitochondria ; Mitochondrial pathology ; Proteins / Conformation ; Adenosine Diphosphate / metabolism ; Adenosine triphosphate / Metabolism ; Binding Sites ; Biological Transport, Active ; Calcium / metabolism ; Carrier Proteins ; Humans ; Mitochondria / metabolism ; Mitochondrial ADP, ATP Translocases ; Mitochondrial Diseases ; Mitochondrial Membrane Transport Proteins ; Mitochondrial Proteins ; Protein Conformation
    Description / Table of Contents: Contents: The involvement of salt bridge networks in the transport mechanism -- Conformational changes in transport -- Involvement of mitochondrial carriers in human diseases -- Calcium regulation of transport
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (46 min.) : color, sound).
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  • 8
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    London : Henry Stewart Talks
    Keywords: Giant cell arteritis ; Biopsy ; Diagnostic Imaging ; Giant Cell Arteritis / diagnosis ; Giant Cell Arteritis / drug therapy ; Giant Cell Arteritis / epidemiology ; Risk Factors ; Steroids
    Description / Table of Contents: Contents: Pathogenesis of GCA -- Common presenting features -- Role of biopsy and diagnostic imaging studies -- Review of available therapies, including steroid-sparing options -- Survival and risk of end-organ damage
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 9
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    London : Henry Stewart Talks
    Keywords: Attention-deficit hyperactivity disorder ; Physician and patient ; Vaccination of children ; Vaccines industry ; Attention Deficit Disorder with Hyperactivity / drug therapy ; Child ; Communication ; Drug Industry ; Family Practice ; Health Education ; Parents ; Pharmaceutical Preparations ; Referral and Consultation ; Treatment Refusal ; Vaccination
    Description / Table of Contents: Contents: The issue of compliance in children -- Consultation time as a key resource in the assessment for children -- The effects of available online information and media on parents' decisions -- Attention deficit disorders -- Refusal of parents to vaccinate their children -- The importance of proper clinician-parent communication -- How can pharmaceutical companies help increase compliance in children
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (16 min.))
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  • 10
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Biological models ; Computational Biology ; Genomics ; Systems Biology ; Computational Biology ; Metabolic Networks and Pathways ; Metabolomics ; Systems Biology / methods
    Description / Table of Contents: Contents: Recent approaches in system biology and modeling -- Different compartment and building of genome scale metabolic network models -- Using system biology markup languages (SBML) to represent metabolic models -- Main concepts in SBML model building
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (23 min.) : color, sound).
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  • 11
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    London : Henry Stewart Talks
    Keywords: Alzheimer's disease / Chemotherapy ; Alzheimer's disease / Prevention ; Amyloid ; Drug development ; Alzheimer Disease / diagnosis ; Alzheimer Disease / drug therapy ; Alzheimer Disease / prevention & control ; Cell Membrane / metabolism ; Drug Discovery ; Plaque, Amyloid / drug therapy
    Description / Table of Contents: Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (10 min.))
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  • 12
    Keywords: Iron sulfur proteins ; Mitochondria / metabolism ; Mitochondrial pathology ; Iron-Sulfur Proteins / chemistry ; Iron-Sulfur Proteins / metabolism ; Mitochondrial Diseases ; Mitochondrial Proteins / chemistry ; Mitochondrial Proteins / metabolism ; Saccharomyces cerevisiae Proteins
    Description / Table of Contents: Contents: Structure and functions of iron-sulfur (Fe/S) clusters and proteins -- Analysis of Fe/S proteins and their biogenesis -- Mechanisms of Fe/S protein assembly in mitochondria -- Mitochondrial "Fe/S diseases."
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (49 min.) : color, sound).
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  • 13
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    London : Henry Stewart Talks
    Keywords: Genetic engineering / Environmental aspects ; Genetic engineering / Methodology ; Genetic engineering / Research ; Malaria / Prevention ; Malaria / Africa ; Mosquitoes / Control ; Mosquitoes / Genetic engineering ; Anopheles / genetics ; Ecological and Environmental Phenomena ; Gene Drive Technology / ethics ; Gene Drive Technology / methods ; Malaria / prevention & control ; Mosquito Control / methods ; Mosquito Vectors / genetics
    Description / Table of Contents: Contents: Gene drive technology used for the elimination of malaria in Africa -- Evaluation and deployment of genetically engineered mosquitoes (GEM) with gene drive into natural malaria-transmitting mosquito populations -- Fitness of GEM relative to their wild counterparts -- Strategies for maintaining and evaluating overall fitness -- Criteria for the establishment of field trial sites for the release and evaluation of GEM -- Implementation of GEM for malaria elimination/eradication at the continental scale
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 14
    Keywords: Biological models ; Insects / Genetic engineering ; Mosquitoes / Control ; Mosquitoes / Genetic engineering ; Population genetics ; Animals, Genetically Modified ; Anopheles / genetics ; Gene Drive Technology ; Genetics, Population ; Models, Genetic ; Mosquito Control / methods ; Mosquito Vectors / genetics ; Population Dynamics ; Transgenes / genetics
    Description / Table of Contents: Contents: Gene drive -- Suppression drive -- Transgenic gene drives -- Level of detail in a model -- Detailed model of Anopheles -- Simple and complex models of other gene drives and gene drive reversal -- Engineered under dominance -- Age and spatial models -- Spatial release models -- Medea -- Mosquito model in a dynamic city -- Skeeter Buster
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (45 min.) : color, sound).
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  • 15
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    London : Henry Stewart Talks
    Keywords: Amyotrophic lateral sclerosis ; Medicine / Research ; Personalized medicine ; Amyotrophic Lateral Sclerosis / etiology ; Amyotrophic Lateral Sclerosis / genetics ; Amyotrophic Lateral Sclerosis / therapy ; Precision Medicine / trends ; Translational Medical Research / trends
    Description / Table of Contents: Contents: The impact of recent genetic discoveries on ALS therapy options -- Prevention vs treatment approaches -- A personalized medicine approach to ALS treatment -- Current open questions regarding the causes of ALS -- Ongoing trials and future directions for ALS therapies -- Translational research and academic-industry collaborations
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (25 min.)).
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  • 16
    Keywords: Dengue / Prevention ; Insects / Genetic engineering ; Malaria / Prevention ; Mosquitoes / Control ; Mosquitoes / Genetic engineering ; Zika virus ; Aedes / genetics ; Animals, Genetically Modified ; CRISPR-Cas Systems / genetics ; Dengue / prevention & control ; Gene Drive Technology ; Malaria / prevention & control ; Mosquito Control / methods ; Mosquito Vectors / genetics ; Zika Virus Infection / prevention & control
    Description / Table of Contents: Contents: Mosquitoes are the most dangerous animals in the world -- Aedes aegypti spread Dengue, Zika and other viral-borne diseases -- Suppression of Aedes through release of genetically engineered males in ways to prevent their persistence in the environment
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (22 min.) : color, sound).
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  • 17
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    London : Henry Stewart Talks
    Keywords: Brain stimulation / Therapeutic use ; Parkinson's disease / Pathology ; Schizophrenia / Treatment ; Deep Brain Stimulation ; Parkinson Disease / pathology ; Risk ; Schizophrenia / pathology ; Schizophrenia / therapy
    Description / Table of Contents: Contents: General characteristics of schizophrenia -- Unmet needs in patients -- Amenability of the patient population to DBS -- Comparing schizophrenia to Parkinson's disease, essential tremor & dystonia -- Targets and risks of DBS -- When risks outweigh benefits of DBS
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 18
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    London : Henry Stewart Talks
    Keywords: Cancer / Chemotherapy ; Cancer / Treatment ; Oncology ; Drug-Related Side Effects and Adverse Reactions ; Neoplasms / drug therapy ; Neoplasms / surgery ; Neoplasms / therapy ; Palliative Care ; Radiotherapy
    Description / Table of Contents: Contents: Cancer basics -- Staging -- Treating cancer -- Surgery -- Radiation -- Chemotherapy -- Log-Kill Hypothesis -- Hormone therapy -- Targeted therapy -- A companion diagnostic -- Treatment resistance -- The tumour genome -- Reducing side effects -- Palliative care
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (38 min.) : color, sound).
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  • 19
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Computational Biology ; Liquid chromatography / Data processing ; Mass spectrometry / Data processing ; Metabolites ; Bioinformatics / methods ; Chromatography, Liquid / methods ; Computational Biology / methods ; Mass Spectrometry / methods ; Metabolomics / methods ; Research Design / methods ; Research Design / statistics & numerical data ; Software
    Description / Table of Contents: Contents: Peak picking in xcms -- xcms – CentWave -- Wavelet based filtering for chromatographic peaks -- LC-MS metabolomics -- Peak alignment -- Warping: some general considerations -- Missing values -- Sample normalization -- Annotation
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 20
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    London : Henry Stewart Talks
    Keywords: Clinical trials / Statistical methods ; Drug development / Statistical methods ; Drugs / Dose-response relationship ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Drug Dosage Calculations ; Models, Statistical ; Patient Selection ; Research Design / methods ; Research Design / statistics & numerical data
    Description / Table of Contents: Contents: More than two ordered groups -- Completely ordered groups -- Partially ordered groups -- Methods for ordered groups -- Dose allocations
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (20 min.) : color, sound).
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  • 21
    Keywords: Biological models ; Insects / Genetic engineering ; Mosquitoes / Genetic engineering ; Population genetics ; Algorithms ; Culicidae / genetics ; Gene Drive Technology ; Genes, Insect ; Models, Biological ; Models, Genetic ; Mosquito Control / methods ; Population Dynamics ; Transgenes ; Translocation, Genetic
    Description / Table of Contents: Contents: Mathematical modeling of gene drive -- Medea -- Toxin-antidote-based underdominant systems -- Reciprocal chromosomal translocations -- Spatially-structured modeling frameworks -- Confineable homing-based gene drive systems -- Potential for invasive homing-based systems following field trials
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (52 min.) : color, sound).
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  • 22
    Keywords: Crisis intervention (Mental health services) / Iraq ; Evidence-Based Medicine ; Post-traumatic stress disorder in adolescence ; Post-traumatic stress disorder in children ; Adolescent ; Child ; Crisis Intervention ; Evidence-Based Medicine ; Pilot Projects ; Stress Disorders, Post-Traumatic / therapy
    Description / Table of Contents: Contents: CIPCA (crisis intervention program for children and adolescents) preventing post-traumatic psychopathology: aims, structure, function and instruments -- Metin health house -- CIPCA pilot project
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (15 min.) : color, sound).
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  • 23
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    London : Henry Stewart Talks
    Keywords: Embryology ; Gametogenesis ; Mitochondria ; Oogenesis ; Aging / physiology ; Cumulus Cells ; DNA, Mitochondrial ; Embryonic Development ; Mitochondria ; Oocytes ; Oogenesis ; Reproduction / genetics
    Description / Table of Contents: Contents: Mitochondria and embryogenesis -- Mitochondria and ovarian ageing -- The role of cumulus granulosa cells -- Mitochondrial genetics and fertility -- Targeting mitochondria to improve oocyte quality
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (30 min.) : color, sound).
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  • 24
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    London : Henry Stewart Talks
    Keywords: Systemic scleroderma ; Biomarkers ; Fibrosis ; Immune System / pathology ; Scleroderma, Systemic / classification ; Scleroderma, Systemic / pathology ; Scleroderma, Systemic / therapy
    Description / Table of Contents: Contents: Complications associated with systemic sclerosis -- The disease process in systemic sclerosis -- Disease pathogenesis -- Humoral immune system alterations -- Fibrosis -- Molecular mechanisms in systemic sclerosis -- Systemic sclerosis classification criteria -- Biomarkers -- The modified Rodnan Skin Score -- Skin thickness progression rate -- Effectiveness of therapies -- New targeted therapies for SSc fibrosis
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (36 min.) : color, sound).
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  • 25
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    London : Henry Stewart Talks
    Keywords: Cervix uteri / Cancer ; Clinical Trials ; Papillomavirus diseases / Vaccination ; Papillomaviruses ; Antibody Formation ; Immunization Programs ; Papillomaviridae / genetics ; Papillomavirus Infections / epidemiology ; Papillomavirus Infections / prevention & control ; Papillomavirus Vaccines ; Randomized Controlled Trials as Topic ; Secondary Prevention ; Uterine Cervical Neoplasms / epidemiology ; Uterine Cervical Neoplasms / etiology ; Uterine Cervical Neoplasms / prevention & control ; Vaccination / trends ; Viral Vaccines
    Description / Table of Contents: Contents: Human papillomavirus (HPV) lifecycle -- Cervical HPV infection and progression to cancer -- Primary and secondary prevention method -- Prophylactic HPV vaccines -- Efficacy and durability of HPV viral-like particles (VPL) vaccines -- The potential of a one-dose vaccination program -- Randomized trials -- Vaccine protection against pre-malignant lesions -- Vaccine safety record & effectiveness -- HPV vaccine uptake -- Antibody response -- Increasing vaccine use
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (45 min.) : color, sound).
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  • 26
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    London : Henry Stewart Talks
    Keywords: Calcium / Physiological effect ; Cell Death ; Cellular signal transduction ; Lysosomal storage diseases ; Lysosomes ; Autophagy / physiology ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism ; Calcium channels ; Cytoplasm / metabolism ; Gene Expression Regulation ; Lysosomal storage diseases ; Lysosomes / metabolism ; Phosphorylation ; Protein Transport ; Transcription, Genetic ; Transient Receptor Potential Channels
    Description / Table of Contents: Contents: Lysosome as degradative organelle -- Transcriptional regulation of lysosomal and autophagic function -- Promoting clearance through overexpression of TFEB in lysosomal storage disorders -- TFEB regulation by phosphorylation -- Imaging approaches to identify phosphatase regulating TFEB nuclear translocation -- Role of the lysosomal calcium channel TRPML1 in TFEB nuclear translocation
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (17 min.) : color, sound).
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  • 27
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    London : Henry Stewart Talks
    Keywords: Cell Physiology ; Mitochondria ; Mitochondrial pathology ; Muscles ; Microscopy, Electron, Scanning Transmission ; Mitochondria / physiology ; Mitochondria / ultrastructure ; Mitochondrial Diseases ; Mitochondrial Dynamics ; Mitochondrial Membranes ; Multivariate Analysis ; Muscle, Skeletal / physiology ; Organelle Biogenesis
    Description / Table of Contents: Contents: Mitochondrial morphology transitions -- Endosymbiosis -- Scanning & transmission electron microscopy of mitochondria -- Intermyofibrillar and subsarcolemmal mitochondria -- Metabolism & regulation of mitochondrial dynamics -- Transmitochondrial cristae coordination -- Inter-mitochondrial junctions -- Mitochondrial ultrastructure in mitochondrial disease -- Reconstructions and quantitative morphometry -- Multivariate analysis -- Mitochondrial nanotunnels
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 28
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    London : Henry Stewart Talks
    Keywords: Arthritis ; Gout ; Joints / Diseases ; Pain / Treatment ; Acute Disease ; Arthralgia / diagnosis ; Arthralgia / drug therapy ; Arthritis / diagnosis ; Arthritis / drug therapy ; Diagnosis, Differential ; Gout / diagnosis ; Gout / drug therapy ; Pain Management
    Description / Table of Contents: Contents: Comparison of arthralgia and arthritis -- NO PADS acronym for diagnosis -- Disease distribution -- Acute monoarthritis differential diagnosis -- A practical treatment process -- Gout management -- Common uric-acid lowering medications
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (48 min.) : color, sound).
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  • 29
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    London : Henry Stewart Talks
    Keywords: Autoimmune Diseases ; Sjogren's Syndrome ; Autoimmunity ; Lymphoma ; Risk Factors ; Sjogren's Syndrome / immunology ; Sjogren's Syndrome / pathology ; Sjogren's Syndrome / therapy
    Description / Table of Contents: Contents: Introduction to Sjögren's syndrome -- Humoral and cellular autoimmune responses in Sjögren's syndrome -- Description of heterogenic clinical features of disease -- Pathogenetic/immunopathologic aspects and associations with clinical phenotypes -- The need for precise therapeutic approaches -- Development and features of lymphoma in Sjögren's syndrome -- Risk factors for development of severe disease -- Biomarkers for disease severity, outcome and lymphoma
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 30
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    London : Henry Stewart Talks
    Keywords: Developmental genetics ; Endometriosis ; Endometriosis / genetics ; Endometriosis / pathology ; Epigenesis, Genetic ; Genomics
    Description / Table of Contents: Contents: Basic theories & hypotheses on endometriosis -- A systems genetic view of endometriosis -- The junctional zone and its association with endometriosis -- Genomics of endometriosis -- The developmental genetic program of endometriosis (EMDP) -- Critical periods (CP) I, II, and III of EMDP -- Implications of the EMDP hypothesis -- Validating the EMDP hypothesis
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (20 min.) : color, sound).
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  • 31
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    London : Henry Stewart Talks
    Keywords: Blood-Brain Barrier ; Brain / Diseases ; Drug Delivery Systems ; Nanobiotechnology ; Nanomedicine ; Alzheimer Disease / drug therapy ; Blood-Brain Barrier / drug effects ; Blood-Brain Barrier / physiopathology ; Brain Diseases / drug therapy ; Drug Delivery Systems / methods ; Nanomedicine / methods ; Nanostructures / therapeutic use ; Nanotechnology ; Neurology / trends
    Description / Table of Contents: Contents: The Blood-Brain Barrier in healthy and diseased state -- Planning a nano-4-neuro -- Strategies for Blood-Brain Barrier crossing with nanotechnology -- Technological issues -- What we learn and what to do in NPs for CNS -- Exploitation of endogenous/exogenous pathways -- Proofs of concept and pharmacological evidences -- The case of Alzheimer's Disease: analysis of nanomedicine applications
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (50 min.) : color, sound).
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  • 32
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    London : Henry Stewart Talks
    Keywords: Genetic disorders ; Methemoglobinemia ; Cytochrome-B(5) Reductase / deficiency ; Diagnosis, Differential ; Methemoglobinemia / congenital ; Methemoglobinemia / diagnosis ; Methemoglobinemia / therapy ; Mutation ; Phenotype
    Description / Table of Contents: Contents: Formation of methemoglobinemia -- Review of methemoglobinemias types -- Cytochrome b5 reductase (Cytb5 R) -- Mutations and clinical phenotypes of Cytb5 R deficiency -- Differential diagnosis from other methemoglobinemias -- Therapy of methemoglobinemia
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (26 min.) : color, sound).
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  • 33
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    London : Henry Stewart Talks
    Keywords: Antifungal agents ; Biological models ; Caenorhabditis elegans ; Cellular signal transduction ; Host-parasite relationships ; Natural immunity ; Peptide antibiotics ; Antifungal agents ; Anti-Infective Agents ; Caenorhabditis elegans Proteins / immunology ; Caenorhabditis elegans / enzymology ; Caenorhabditis elegans / Genetics ; Caenorhabditis elegans / immunology ; Epidermis / immunology ; Fungi / immunology ; Gene Expression Regulation, Fungal ; Host-Pathogen Interactions ; Immunity, Innate / genetics ; Models, Biological ; Peptides ; Signal Transduction
    Description / Table of Contents: Contents: Ecology of C. elegans -- Historical background to host-parasite studies with nematodes -- D. coniospora, a natural pathogen of C. elegans -- Fungal infection and injury induce antimicrobial peptide genes -- Genetics to understand the control of antimicrobial peptide gene expression -- The importance of the nematode surface coat -- Signal transduction pathways that control antimicrobial peptide gene expression
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 34
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    London : Henry Stewart Talks
    Keywords: Active oxygen ; Mitochondria ; Hydrogen Peroxide / antagonists & inhibitors ; Hydrogen Peroxide / metabolism ; Mitochondria / metabolism ; Mitochondria, Muscle / metabolism ; Reactive Oxygen Species ; Superoxides / antagonists & inhibitors ; Superoxides / metabolism
    Description / Table of Contents: Contents: The reduction of oxygen and production of reactive oxygen species (ROS) -- Twelve sites of ROS production in mitochondria -- Measurement of specific sites in mitochondria -- Capacity of each site in optimised conditions -- Capacities versus native rates -- Contribution of each site under native conditions with conventional/physiological substrates
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (37 min.) : color, sound).
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  • 35
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    London : Henry Stewart Talks
    Keywords: Antineoplastic Agents ; Cancer / Chemotherapy ; Cancer / Treatment ; Cell Death ; Chronic myeloid leukemia ; Antineoplastic Agents / therapeutic use ; Autophagy / drug effects ; Autophagy / physiology ; Hematopoiesis / physiology ; Hematopoietic Stem Cells / drug effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy ; Neoplasms / drug therapy ; Neoplastic Stem Cells / drug effects
    Description / Table of Contents: Contents: History of autophagy -- Types of autophagy -- Methods for monitoring autophagy -- Autophagy and cancer -- The role of autophagy in haematopoiesis -- Autophagy & chronic myeloid leukaemia (CML) -- Future autophagy inhibitors
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (32 min.) : color, sound).
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  • 36
    Keywords: Dental anthropology ; Forensic anthropology ; Forensic dentistry ; Gene Flow ; Human population genetics ; Teeth / Anatomy ; Anthropology, Physical / methods ; Forensic Anthropology / methods ; Forensic Dentistry / methods ; Gene Flow ; Paleodontology / methods ; Population Groups ; Tooth / anatomy & histology
    Description / Table of Contents: Contents: Evolutionary mechanisms underlying variation in dental morphology -- Dental morphology and population history -- Using combination of traits to identify ancestry of individuals in a forensic context
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (33 min.) : color, sound).
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  • 37
    Keywords: Dental anthropology ; Forensic dentistry ; Human population genetics ; Teeth / Anatomy ; Anthropology, Physical ; Forensic dentistry ; Paleodontology ; Population Groups ; Tooth Crown / anatomy & histology ; Tooth Root / anatomy & histology ; Tooth / anatomy & histology
    Description / Table of Contents: Contents: The importance of teeth in anthropology -- Dental morphology -- Nonmetric traits with strong genetic basis -- Traits showing patterned geographic variation on world scale
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 38
    Keywords: Autoimmune Diseases ; Behavior disorders in children / Diagnosis ; Behavior disorders in children / Etiology ; Behavior disorders in children / Treatment ; Nervous system / Diseases ; Pediatric neurology ; Streptococcal infections / Complications ; Autoimmune Diseases / microbiology ; Child Behavior Disorders / diagnosis ; Child Behavior Disorders / etiology ; Child Behavior Disorders / therapy ; Child ; Nervous System Diseases / immunology ; Streptococcal infections / Complications ; Streptococcal Infections / immunology ; Streptococcus pyogenes / immunology
    Description / Table of Contents: Contents: The effect of Group A streptococcal infections on the behaviour of children -- The problem of diagnosis in PANDAS -- Potential mechanisms underlying PANDAS and the role of the immune system -- Current therapeutic interventions and potential future ones -- The importance of developing better diagnostic tools
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (25 min.))
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  • 39
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    London : Henry Stewart Talks
    Keywords: Antiviral Agents ; Drug development ; Hepatitis B / Chemotherapy ; Hepatitis C / Chemotherapy ; Influenza / Chemotherapy ; Virus diseases / Chemotherapy ; Antiviral Agents / therapeutic use ; Drug Discovery ; Hepacivirus / drug effects ; Hepatitis B virus / drug effects ; Hepatitis C virus / drug effects ; Hepatitis, Viral, Human / drug therapy ; Herpesviridae Infections / drug therapy ; Herpesviridae / drug effects ; Influenza, Human / drug therapy ; Orthomyxoviridae / drug effects ; Virus Diseases / drug therapy
    Description / Table of Contents: Contents: Why do we need antiviral drugs? -- Overview of approved antiviral drugs -- Antiviral targets mechanisms and resistance -- Hepatitis C virus: biology and current drugs -- Hepatitis B virus: biology and treatments -- Herpesvirus drugs -- Influenza virus: approved drugs -- Broad-spectrum antivirals -- Diseases for which we need antivirals
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (36 min.) : color, sound).
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  • 40
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    London : Henry Stewart Talks
    Keywords: Complement (Immunology) ; Kidneys / Transplantation ; Complement Activation ; Complement C3a ; Complement C5a ; Complement C5b ; Complement System Proteins / immunology ; Graft Rejection / immunology ; Kidney Transplantation ; Kidney Tubules / injuries ; Transplantation Immunology
    Description / Table of Contents: Contents: Important barriers to successful transplantation -- Tissue compartments affected by injury -- Contribution of local synthesis of complement -- C5a and C5b-9 dependent ischaemic renal tubule injury -- Priming of the T cell response by C3a, C5a -- Triggering complement activation on hypoxic cells
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (51 min.) : color, sound).
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  • 41
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    London : Henry Stewart Talks
    Keywords: Bioinformatics ; Communication of technical information ; Computational Biology ; Information organization ; Information retrieval ; Metabolites ; Computational Biology / methods ; Databases, Factual ; Information Dissemination / methods ; Information Storage and Retrieval / methods ; Metabolomics ; Metadata ; Quality Control ; Reference Standards
    Description / Table of Contents: Contents: Current state of data sharing and exchange standards -- Making efficient use of data for metabolomics -- Metabolomics standard initiative -- Data sharing repositories -- Metabolite annotation/identification -- Capturing metadata -- Metabolomics identification -- Quality control in metabolomics -- Journals for metabolomics data-sharing and reuse
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (38 min.) : color, sound).
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  • 42
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    London : Henry Stewart Talks
    Keywords: Cervix uteri / Cancer ; Papillomavirus diseases / Epidemiology ; Papillomavirus diseases / Vaccination ; Papillomaviruses ; Papillomaviridae ; Papillomavirus Infections / epidemiology ; Papillomavirus Infections / prevention & control ; Papillomavirus Vaccines ; Uterine Cervical Neoplasms / epidemiology ; Uterine Cervical Neoplasms / etiology ; Vaccination
    Description / Table of Contents: Contents: Human Papilloma Virus (HPV): overview, epidemiology & surveillance -- Cervical cancer and its relation to HPV -- The HPV vaccine -- Importance of high vaccine uptake -- Monitoring of adverse events and vaccine effectiveness -- Herd protection effect of vaccine -- Associated reductions in HPV infections, cervical diseases & clinical activity
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (21 min.) : color, sound).
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  • 43
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    London : Henry Stewart Talks
    Keywords: Clinical trials / Design ; Clinical trials / Statistical methods ; Drugs / Testing ; Experimental design ; Therapeutics, Experimental ; Biostatistics / methods ; Data Interpretation, Statistical ; Randomized Controlled Trials as Topic / methods ; Research Design ; Therapies, Investigational
    Description / Table of Contents: Contents: When is "non-inferiority" the correct question for your trial -- Selection of an acceptable margin of non-inferiority -- Selection of the control arm (placebo/active/both) -- How to interpret the study results
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (32 min.) : color, sound).
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  • 44
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    London : Henry Stewart Talks
    Keywords: Anti-vaccination movement / European Union countries ; Anti-vaccination movement / Great Britain ; Anti-vaccination movement / United States ; Communication in public health ; Health attitudes ; Vaccination of children / Complications ; Vaccines / Health aspects ; Anti-Vaccination Movement / trends ; Health knowledge, Attitudes, Practice ; Health Promotion ; Social media ; Vaccination / adverse effects ; Vaccination / trends
    Description / Table of Contents: Contents: Anti-vaccination movements in the US and the EU -- The impact of vaccine opposition on the numbers of measles and influenza cases -- The influence of public and social media on pro/anti-vaccines debate -- Lack of public’s trust in the pharmaceutical industry and regulatory agencies in the US and the EU -- The demographics of anti-vaccinators in the US and the UK -- Challenges in communicating the safety and importance of vaccine to the public
    Notes: Audio interview.
    Pages: 1 online resource (1 streaming audio file (27 min.)).
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  • 45
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    London : Henry Stewart Talks
    Keywords: Aging / Physiological aspects ; Cell metabolism ; Cellular signal transduction ; Exercise / Physiological aspects ; Mitochondria ; Muscles / Physiology ; Aging / physiology ; AMP-Activated Protein Kinases ; Calcium Signaling ; Exercise / physiology ; Mitochondria, Muscle / physiology ; Mitochondria, Muscle / metabolism ; Muscle Fibers, Skeletal / metabolism ; Muscle, Skeletal / metabolism ; Organelle Biogenesis ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Signal Transduction
    Description / Table of Contents: Contents: Calcium signaling in mitochondrial biogenesis -- The role of PGC-1alpha -- PGC-1alpha expression and exercise -- Regulators of the expression of PGC-1alpha -- Overview of mitochondrial assembly -- Activity-induced changes in protein import -- Aging muscle and exercise adaptations -- The mitochondrial life cycle -- Lysosomal adaptations -- Exercise is mitochondrial medicine
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (37 min.) : color, sound).
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  • 46
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    London : Henry Stewart Talks
    Keywords: Antineoplastic Agents ; Cancer / Chemotherapy ; Drugs / metabolism ; Enzymes ; Personalized medicine ; Antineoplastic Agents / pharmacology ; Drug Delivery Systems ; Drug Resistance ; Enzymes / metabolism ; Neoplasms / drug therapy ; Pharmaceutical Preparations / metabolism ; Precision Medicine
    Description / Table of Contents: Contents: Drug metabolism -- Classification of drug metabolizing enzymes (DMEs) -- Clinical significance of DMEs in cancer therapeutics -- Drug delivery -- Drug resistance -- Interindividual variability and precision oncology
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (26 min.) : color, sound).
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  • 47
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    London : Henry Stewart Talks
    Keywords: Evidence-Based Medicine ; Medical care / Quality control ; Medical care / Research ; Evidence-based practice ; Primary health care / Evaluation ; Primary Health Care ; Research
    Description / Table of Contents: Contents: What is primary health care? -- Why does primary health care matter? -- Starfield: primary care assessment tool -- Academic disciplines of primary health care -- Social and cultural influences on health -- New research priorities
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (36 min.) : color, sound).
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  • 48
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    London : Henry Stewart Talks
    Keywords: Drug Delivery Systems ; Nanobiotechnology ; Nanostructured materials ; Pharmaceutical technology ; Drug Delivery Systems ; Infusion Pumps, Implantable ; Nanopores ; Nanotechnology ; Nanowires
    Description / Table of Contents: Contents: Nanomaterials in biological context -- Nanotechnology includes nanomaterials -- Implantable drug delivery systems -- Problem: overcoming injections' poor pharmacokinetics -- Tuning pore size to produce linear diffusion -- Nanoscale pores alter drug diffusion curves (more dose control) -- Nanoporous membrane for improved implantable drug delivery -- Controlled delivery from nanostructured implants -- Challenges in oral delivery -- Devices can be fabricated -- Nanowire interfaces & Cell-nanowire interface -- Adhesive forces -- Improved targeting and retention of microdevices in vivo -- Nanostructured materials: key benefits
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (27 min.) : color, sound).
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  • 49
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    London : Henry Stewart Talks
    Keywords: Adaptive sampling (Statistics) ; Bayesian statistical decision theory ; Clinical trials / Design ; Clinical trials / Statistical methods ; Bayes Theorem ; Biostatistics / methods ; Clinical Trials, Phase II as Topic / methods ; Research Design
    Description / Table of Contents: Contents: Bayesian vs. frequentist perspective -- Learning as data accumulate -- Bayesian inferences -- Bayes theorem -- The Impact of prior -- A simple example: lung cancer and smokers -- Bayesian Basket design
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (23 min.) : color, sound).
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  • 50
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    London : Henry Stewart Talks
    Keywords: Gametogenesis ; Mitochondria ; Oogenesis ; Spermatogenesis ; DNA, Mitochondrial ; Fertility ; Mitochondria ; Oocytes ; Oogenesis ; Spermatogenesis ; Spermatozoa
    Description / Table of Contents: Contents: Introduction to the role of mitochondria in embryonic development -- Mitochondrial life cycle, dynamics, biogenesis and mitophagy -- Mitochondria and gametes: in spermatozoa and spermatogenesis, in oocyte and oogenesis -- The bottleneck theory -- The importance of mtDNA content in oocyte competence
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (31 min.) : color, sound).
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  • 51
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    Stuttgart : Deutscher Apotheker Verl.
    Call number: E030:12/AV
    Pages: 1 CD-ROM
    ISBN: 9783769272178
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    E030:12/AV departmental collection or stack – please contact the library
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  • 52
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    London : Henry Stewart Talks
    Keywords: Antineoplastic agents / Development ; Cellular signal transduction ; Drug development ; Protein Kinases ; Yeast ; ACA-28 cpd ; Antineoplastic Agents / pharmacology ; Drug Discovery ; Extracellular Signal-Regulated MAP Kinases ; MAP Kinase Signaling System / physiology ; Melanoma / drug therapy ; Saccharomyces cerevisiae / drug effects ; Signal Transduction / drug effects
    Description / Table of Contents: Contents: MAPK signalling and its relevance to cancer therapy -- The discovery of ACA-28 -- The use of yeast within drug discovery -- Effect of ACA-28 on the apoptosis of cancer cells -- Implications of ACA-28 in cancer therapeutics
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (23 min.) : color, sound).
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  • 53
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    London : Henry Stewart Talks
    Keywords: Evolution (Biology) ; Gastrointestinal system / Microbiology ; Human body / Microbiology ; Human evolution ; Medical Microbiology ; Probiotics ; Biological Evolution ; Gastrointestinal Microbiome ; Humans / microbiology ; Immune System ; Microbiota ; Probiotics / therapeutic use
    Description / Table of Contents: Contents: Phenotype transfer via the microbiome -- The association between the microbiome and host fitness -- Influence of the microbiome on behavior and mood -- The adaptive immune system selectively controls the microbiota -- Domestication of microbes -- The effect of modern life on our microbiomes -- Probiotics and the microbiome
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (49 min.) : color, sound).