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  • 1
    Digitale Medien
    Digitale Medien
    A measurement of τ polarization in Z^0 decays (1992-8977)
    Amsterdam : Elsevier
    Physics Letters B 294 (1992), S. 466-478 
    Details
    ISSN: 0370-2693
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(92)91549-O
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    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Measurement of the average lifetime of b hadrons (1993-4325)
    Amsterdam : Elsevier
    Physics Letters B 317 (1993), S. 474-484 
    Details
    ISSN: 0370-2693
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(93)91027-K
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  • 3
    Online-Ressource
    Online-Ressource
    Umami : Taste for Health (2024)
    Cham : Springer International Publishing
    Details
    Schlagwörter: Food Microbiology. ; Food science. ; Food Sensory evaluation. ; Nutrition   . ; Food Analysis. ; Chemistry. ; Food Microbiology. ; Food Science. ; Sensory Evaluation. ; Nutrition. ; Food Chemistry.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This Open Access book covers the concept of umami, the unique taste imparted by the amino acid glutamate, was first described in 1908 by Dr. Kikunae Ikeda of Tokyo University. Over the past century, hundreds of studies have explored the mechanistic underpinnings of the taste, leading to the characterization of the umami taste receptor in 2002. How this fifth basic taste figures into nutrition and health, however, remains underexplored. Umami: Taste for Health provides an overview of the relationship between umami and human health. Authors explain how glutamate not only produces a characteristic oral sensation in the mouth but also functions as a signaling molecule to induce physiological responses. With the support of recent studies, the book demonstrates how the taste properties of umami make glutamate a promising substance to lower salt intake, promote satiation and support healthier aging. The text also covers practical culinary applications to increase umami flavor and practical usage of umami for promoting healthy eating. Provides an overview of the relationship between umami and human health; Explores the potential of glutamate to lower salt intake, promote satiation and support healthier aging; Covers practical culinary applications of umami flavor and practical usage of umami for promoting healthy eating.
    Materialart: Online-Ressource
    Seiten: XIII, 198 p. 33 illus. , online resource.
    Ausgabe: 1st ed. 2024.
    ISBN: 9783031326929
    Serie: Food and Health,
    URL: https://doi.org/10.1007/978-3-031-32692-9
    DOI: 10.1007/978-3-031-32692-9
    Sprache: Englisch
    Anmerkung: 1. Umami and MSG -- 2. Sensory Physiology of Umami -- 3. Umami and Salty: A Cooperative Pair -- 4. Protein, Umami and Satiety -- 5. Development and Umami -- 6. Umami and Healthy Aging -- 7. Umami As A Component of Healthy Diets -- 8. Practicalities from Culinology.
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  • 4
    Buch
    Buch
    Basic immunology : functions and disorders of the immune system (2024)
    Philadelphia, PA : Elsevier
    Details
    Schlagwörter: Immunity. ; Hypersensitivity ; Immune System physiology ; Immunologic Deficiency Syndromes.
    Materialart: Buch
    Seiten: v, 345 pages : , illustrations (chiefly color) ; , 24 cm
    Ausgabe: 7th edition.
    ISBN: 9780443105197
    Sprache: Englisch
    Standort/Signatur: Library / QR181:099(7)
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  • 5
    Online-Ressource
    Online-Ressource
    Zebrafish : Methods and Protocols (2024)
    New York, NY : Springer US
    Details
    Schlagwörter: Biological models. ; Biology Technique. ; Biological Models. ; Biological Techniques.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This fully updated edition introduces new tools, models, and analytic insights that position the zebrafish even more strongly as an engine of discovery for developmental and disease biology. Beginning with a section exploring detailed methods for use of zebrafish to model a variety of human diseases, the book continues by illuminating the key ongoing role of the fish model in studies of the vertebrate nervous system, tools and approaches using zebrafish to study stem cell and regenerative biology, as well as techniques in genetics and genomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Zebrafish: Methods and Protocols, Third Edition serves as an invaluable guide to propel advances in developmental biology, disease modeling, and regeneration research using zebrafish and medaka as model systems.
    Materialart: Online-Ressource
    Seiten: XIV, 360 p. 94 illus., 85 illus. in color. , online resource.
    Ausgabe: 3rd ed. 2024.
    ISBN: 9781071634011
    Serie: Methods in Molecular Biology, 2707
    URL: https://doi.org/10.1007/978-1-0716-3401-1
    DOI: 10.1007/978-1-0716-3401-1
    Sprache: Englisch
    Anmerkung: Delivering Traumatic Brain Injury to Larval Zebrafish -- Functional Genomics of Novel Rhabdomyosarcoma Fusion-Oncogenes Using Zebrafish -- Methods to Study Liver Disease Using Zebrafish Larvae -- Developmental Toxicity Assessment Using Zebrafish-Based High Throughput Screening -- Cancer Modeling by Transgene Electroporation in Adult Zebrafish (TEAZ) -- Lineage Tracing of Bone Cells in the Regenerating Fin and during Repair of Bone Lesions -- Primary Culture of Neuronal Populations for Various Downstream Applications -- Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish -- Brain Imaging and Registration in Larval Zebrafish -- Simultaneous Behavioral and Neuronal Imaging by Tracking Microscopy -- Genetic Identification of Neural Circuits Essential for Active Avoidance Fear Conditioning in Adult Zebrafish -- Quantitative Live Imaging of Zebrafish Scale Regeneration: From Adult Fish to Signaling Patterns and Tissue Flows -- Generation of Conditional Knockout Zebrafish Using an Invertible Gene-Trap Cassette -- Spinal Cord Injury and Assays for Regeneration -- Selective Cell Ablation Using an Improved Prodrug-Converting Nitroreductase -- Section Immunostaining for Protein Expression and Cell Proliferation Studies of Regenerating Fins -- In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein -- Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones -- Mutation Knock-In Methods Using Single-Stranded DNA and Gene Editing Tools in Zebrafish -- Generation of Transgenic Fish Harboring CRISPR/Cas9-Mediated Somatic Mutations via a tRNA-Based Multiplex sgRNA Expression -- Scalable CRISPR Screens in Zebrafish Using MIC-Drop -- The Goldfish Genome and Its Utility for Understanding Gene Regulation and Vertebrate Body Morphology.
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  • 6
    Online-Ressource
    Online-Ressource
    Computational Drug Discovery and Design (2024)
    New York, NY : Springer US
    Details
    Schlagwörter: Pharmacology. ; Chemistry Data processing. ; Bioinformatics. ; Pharmacology. ; Computational Chemistry. ; Bioinformatics.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Drug Discovery and Design, Second Edition aims to effectively utilize computational methodologies in discovery and design of novel drugs.
    Materialart: Online-Ressource
    Seiten: XI, 356 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2024.
    ISBN: 9781071634417
    Serie: Methods in Molecular Biology, 2714
    URL: https://doi.org/10.1007/978-1-0716-3441-7
    DOI: 10.1007/978-1-0716-3441-7
    Sprache: Englisch
    Anmerkung: Computer-Aided Drug Discovery and Design – Recent Advances and Future Prospects -- Virtual Screening Process - A Guide in Modern Drug Designing -- Molecular dynamics as a tool for virtual ligand screening -- Antiviral Drug Target Identification and Ligand Discovery -- GRAMM webserver for protein docking -- Protein–ligand blind docking using CB-Dock2 -- Applications of Molecular Dynamics Simulations in Drug Discovery -- Molecular dynamics simulation-based prediction of glycosaminoglycan interactions with drug molecules -- Mining chemogenomic spaces for prediction of drug-target interactions -- Expanding the landscape of amyloid sequences with CARs-DB: a database of polar amyloidogenic peptides from disordered proteins -- Accelerating molecular dynamics simulations for drug discovery -- Exploring the Role of Chemoinformatics in Accelerating Drug Discovery: A Computational Approach. -Recent Deep-Learning Applications to Structure-Based Drug Design -- Techniques for Developing Reliable Machine Learning Classifiers Applied to Understanding and Predicting Protein:Protein Interaction Hot Spots -- AI driven enhancements in drug screening and optimisation -- Applications of big data and AI-driven technologies in CADD (computer-aided drug design) -- Artificial Intelligence in ADME Property Prediction -- Accelerating the discovery and design of antimicrobial peptides with artificial intelligence.
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  • 7
    Online-Ressource
    Online-Ressource
    Tissue-Resident Macrophages : Methods and Protocols (2024)
    New York, NY : Springer US
    Details
    Schlagwörter: Cytology. ; Immunology. ; Bacteria. ; Cell Biology. ; Immunology. ; Bacteria.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.
    Materialart: Online-Ressource
    Seiten: XVI, 576 p. 128 illus., 120 illus. in color. , online resource.
    Ausgabe: 1st ed. 2024.
    ISBN: 9781071634370
    Serie: Methods in Molecular Biology, 2713
    URL: https://doi.org/10.1007/978-1-0716-3437-0
    DOI: 10.1007/978-1-0716-3437-0
    Sprache: Englisch
    Anmerkung: Macrophage Development and Function -- Fate Mapping Macrophages: From Ontogeny to Functions -- Studying Autophagy in Microglia: Overcoming the Obstacles -- Hemocyte Nuclei Isolation from Adult Drosophila melanogaster for snRNA-Seq -- Isolation of Tissue Macrophages in Adult Zebrafish -- Genetic and Immunohistochemistry Tools to Visualize Rat Macrophages In Situ -- Phenotyping of Macrophages in Human Immune System Mice -- Fate-Mapping of Yolk Sac-Derived Macrophages -- Fate-Mapping of Hematopoietic Stem Cell-Derived Macrophages -- Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue -- Isolation and Flow Cytometry Analysis of Macrophages from the Dermis -- Isolation and Flow Cytometry Analysis of Macrophages from the Kidney -- Isolation and Flow Cytometry Analysis of Intestinal Macrophages -- Isolation and Characterization of Testis Macrophages Using Flow Cytometry -- Studying Macrophages in the Murine Fatty Liver Using Flow Cytometry and Confocal Microscopy -- Isolation, Ex Vivo Expansion, and Lentiviral Transduction of Alveolar Macrophages -- Translatome Profiling of Tissue-Resident Macrophages Using the RiboTag Approach -- Spectral Flow Cytometry Analysis of Resident Tissue Macrophages -- Unveiling Macrophage Heterogeneity and Their Spatial Distribution Using Multiplexed Tissue Imaging -- 3D Imaging of Macrophages in Complete Organs -- Whole-Mount Imaging of Adipose Tissue Macrophages -- Functional In Vivo Imaging of Macrophages -- Elucidating Immune Monitoring of Tissue-Resident Macrophages by Intravital Microscopy -- Combined Host-Pathogen Fate Mapping to Investigate Lung Macrophages in Viral Infection -- Measuring the Metabolic State of Tissue-Resident Macrophages via SCENITH -- Analyzing Fcg-Receptor Interactions on Monocytes with the Proximity Ligation Assay (PLA) -- Studying Efferocytosis Dynamics in Tissue-Resident Macrophages Ex Vivo -- Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation -- Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation -- Detection of G-Quadruplex DNA Structures in Macrophages -- Adaptation of Human iPSC-Derived Macrophages Towards an Alveolar Macrophage-Like Phenotype Post Intra-Pulmonary Transfer into Murine Models -- Tackling Tissue Macrophage Heterogeneity by SplitCre Transgenesis -- Automated Cell Counting of Macrophages In Situ -- Morphometric Analyses of Macrophages -- Combined Analysis of mRNA Expression and Open Chromatin in Microglia.
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  • 8
    Unbekannt
    Unbekannt
    Fields Virology.; Vol 4,: Fundamentals / (2024)
    Philadelphia : Wolters Kluwer
    Details
    Materialart: Unbekannt
    Seiten: vii, 668 p. : , ill.
    Ausgabe: 7th ed.
    ISBN: 9781975112516
    Sprache: Englisch
    Anmerkung: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Standort/Signatur: Library / QR360:271(7)/4
    Standort/Signatur: F035 / F035:014
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  • 9
    Online-Ressource
    Online-Ressource
    High Performance Computing for Drug Discovery and Biomedicine (2024)
    New York, NY : Springer US
    Details
    Schlagwörter: Bioinformatics. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Computational and Systems Biology. ; Pharmacology. ; Biomedical Research.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
    Materialart: Online-Ressource
    Seiten: XIII, 429 p. , online resource.
    Ausgabe: 1st ed. 2024.
    ISBN: 9781071634493
    Serie: Methods in Molecular Biology, 2716
    URL: https://doi.org/10.1007/978-1-0716-3449-3
    DOI: 10.1007/978-1-0716-3449-3
    Sprache: Englisch
    Anmerkung: Introduction to Computational Biomedicine -- Introduction to High Performance Computing -- Computational Biomedicine (CompBioMed) Centre of Excellence: Selected Key Achievements -- In Silico Clinical Trials: Is It Possible? -- Bayesian Optimization in Drug Discovery -- Automated Virtual Screening -- The Future of Drug Development with Quantum Computing -- Edge, Fog, and Cloud Against Disease: The Potential of High-Performance Cloud Computing for Pharma Drug Discovery -- Knowledge Graphs and Their Applications in Drug Discovery -- Natural Language Processing for Drug Discovery Knowledge Graphs: Promises and Pitfalls -- Alchemical Free Energy Workflows for the Computation of Protein-Ligand Binding Affinities -- Molecular Dynamics and Other HPC Simulations for Drug Discovery -- High Throughput Structure-Based Drug Design (HT-SBDD) Using Drug Docking, Fragment Molecular Orbital Calculations, and Molecular Dynamic Techniques -- HPC Framework for Performing In Silico Trials Using a 3D Virtual Human Cardiac Population as Means to Assess Drug-Induced Arrhythmic Risk -- Effect of Muscle Forces on Femur during Level Walking Using a Virtual Population of Older Women -- Cellular Blood Flow Modeling with HemoCell -- A Blood Flow Modeling Framework for Stroke Treatments -- Efficient and Reliable Data Management for Biomedical Applications -- Accelerating COVID-19 Drug Discovery with High-Performance Computing -- Teaching Medical Students to Use Supercomputers: A Personal Reflection.
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  • 10
    Online-Ressource
    Online-Ressource
    Vagus Nerve Stimulation (2024)
    New York, NY : Springer US
    Details
    Schlagwörter: Neurosciences. ; Neuroscience.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This volume covers the latest research and development in the areas of Vagus Nerve Stimulation (VNS) as it relates to bioelectronic medicine from neonate to adult. The chapters in this book cover topics such as invasive and non-invasive VNS including methodological considerations (study design, stimulation parameters, and use of heart rate variability metrics); mechanisms of action (automatic regulation and immune plasticity); and disorders where VNS approaches may be therapeutic (migraine and cluster headaches, mood disorders, trauma-related disorders, and language learning). In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and thorough, Vagus Nerve Stimulation is a valuable resource for both novice and expert preclinical and clinical scientists, clinicians, physicians, and scholars who are interested in learning more about this exciting and developing field.
    Materialart: Online-Ressource
    Seiten: XXII, 206 p. 26 illus., 19 illus. in color. , online resource.
    Ausgabe: 1st ed. 2024.
    ISBN: 9781071634653
    Serie: Neuromethods, 205
    URL: https://doi.org/10.1007/978-1-0716-3465-3
    DOI: 10.1007/978-1-0716-3465-3
    Sprache: Englisch
    Anmerkung: Vagus Nerve Stimulation in Peripheral Targets -- Vagal Nerve Stimulation Through the Lens of the Polyvagal Theory: Recruiting Neurophysiological Mechanisms to Dampen Threat Reactions and Promote Homeostatic Functions -- Heart Rate Variability as a Biomarker for Electrical Vagus Nerve Stimulation -- Vagus Nerve Manipulation and Microglial Plasticity in the Prenatal Brain -- Neonatal Sepsis is Diminished by Cervical Vagus Nerve Stimulation and Tracked Non-Invasively by ECG: A Pilot Report and Dataset in the Piglet Model -- Cognitive Enhancement through Vagus Nerve Stimulation: Methodological Considerations for Behavioral Studies in Rats -- Better Mood through Vagus Nerve Stimulation -- Transcutaneous Vagal Nerve Stimulation in Trauma Spectrum Psychiatric Disorders -- Vagus Nerve Stimulation for Migraine and Cluster Headaches -- Vagus Nerve Stimulation and Language Learning. .
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  • 11
    Online-Ressource
    Online-Ressource
    Food Allergens : Methods and Protocols (2024)
    New York, NY : Springer US
    Details
    Schlagwörter: Immunology. ; Allergy. ; Food science. ; Immunology. ; Allergology. ; Food Science.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed volume provides a comprehensive collection of methods and protocols in food allergy and food allergens studies. The selected protocols explore the study of food allergens, from recombinant production, purification procedures, IgE and T cell epitopes characterization, to allergen structure description, cellular responses, and tolerance induction, through a variety of techniques and animal models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Food Allergens: Methods and Protocols serves as an ideal reference for scientists at all stages involved in the study of food allergy and allergenic components.
    Materialart: Online-Ressource
    Seiten: XII, 377 p. 73 illus., 57 illus. in color. , online resource.
    Ausgabe: 1st ed. 2024.
    ISBN: 9781071634530
    Serie: Methods in Molecular Biology, 2717
    URL: https://doi.org/10.1007/978-1-0716-3453-0
    DOI: 10.1007/978-1-0716-3453-0
    Sprache: Englisch
    Anmerkung: Food Allergens of Plant and Animal Origin: Classification, Characteristics, and Properties -- Purification of Food Allergens from Their Natural Sources: Chromatographic Methods -- Recombinant Production of Food Allergens in Yeast Pichia pastoris -- Yeast Surface Display Methodology for the Characterization of Food Allergens In Situ -- Characterization of Linear IgE-Binding Epitopes in Food Allergens -- Characterization of T-Cell Epitopes in Food Allergens by Bioinformatic Tools -- Phage Immunoprecipitation Sequencing (PhIP-Seq) for Analyzing Antibody Epitope Repertoires against Food Antigens -- 1D-, 2D-Gel Electrophoresis, Immunoblotting, and Enzyme-Linked Immunosorbent Assay (ELISA) for the Study of Food Allergens -- Preparation of Blinded Food Matrixes for Clinical Oral Challenges -- Structural Characterization of Food Allergens by Nuclear Magnetic Resonance Spectroscopy -- Co-Culture of Human Dendritic and T Cells for the Study of Specific T Cell-Mediated Responses against Food Allergens -- Evaluation of the Suppressive Capacity of Regulatory T Cells in Food Allergy Research -- Mass Cytometry in Food Allergy Research -- Indirect Basophil Activation Test for Peanut Allergy Diagnosis Using Human Donor Basophils -- Standardization of Food Allergen Measurements Using Multiplex Array Technology -- Biosensors for the Detection of Food Allergens -- Standardization of a Mass Spectrometry-Based Workflow for Food Allergen Quantification -- Identifying Similar Allergens and Potentially Cross-Reacting Areas Using Structural Database of Allergenic Proteins (SDAP) Tools and D-Graph -- Validation Procedures for Quantification of Food Allergens by Enzyme-Linked Immunosorbent Assay (ELISA) -- Detection of Bet v 1 Homologous Proteins and Plant Profilins by Indirect ELISA -- A Mouse Model of Shrimp Allergy with Cross-Reactivity to Crab and Lobster -- Animal Models in the Study of Food Allergens: Long-Term Maintenance of Allergic Reactivity in Mouse Models of Food Allergy -- Study of MicroRNAs Expression in Food Allergy -- De Novo Transcriptomic Analyses to Identify and Compare Allergens in Foods -- Chromatin Immunoprecipitation Sequencing (ChIP-Seq) Assay in Food Allergy Research.
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  • 12
    facet.materialart.
    Unbekannt
    S2k guideline for diving accidents (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS German Medical Science; VOL: 21; DOC01 /20230303/
    Details
    Publikationsdatum: 2023-03-27
    Beschreibung: For the purposes of this guideline, a diving accident is defined as an event that is either potentially life-threatening or hazardous to health as a result of a reduction in ambient pressure while diving or in other hyperbaric atmospheres with and without diving equipment. This national consensus-based guideline (development grade S2k) presents the current state of knowledge and recommendations on the diagnosis and treatment of diving accident victims. The treatment of a breath-hold diver as well as children and adolescents does not differ in principle.In this regard only unusual tiredness and itching without visible skin changes are mild symptoms.The key action statements: on-site 100% oxygen first aid treatment, immobilization/no unnecessary movement, fluid administration and telephone consultation with a diving medicine specialist are recommended.Hyperbaric oxygen therapy (HBOT) remains unchanged as the established treatment in severe cases, as there are no therapeutic alternatives. The basic treatment scheme recommended for diving accidents is hyperbaric oxygenation at 280 kPa.
    Beschreibung: Ein Tauchunfall im Sinne dieser Leitlinie ist ein potenziell lebensbedrohliches oder gesundheitsschädigendes Ereignis, hervorgerufen durch Abfall des Umgebungsdruckes beim Tauchen oder aus sonstiger hyperbarer Atmosphäre mit und ohne Tauchgerät. Diese nationale S2k-Leitlinie legt den aktuellen Stand der Erkenntnisse und der konsentierten Empfehlungen in der Diagnostik und Behandlung von Patienten nach Tauchunfällen dar. Die Behandlung von Apnoetauchern sowie Kindern und Jugendlichen unterscheidet sich prinzipiell nicht.Milde Symptome sind nur die auffällige Müdigkeit und ein Hautjucken ohne sichtbare Hautveränderungen.Wesentliche Bedeutung bei der Versorgung von Tauchunfällen hat die frühzeitige Atmung von 100%igem Sauerstoff. Weiterhin werden die Ruhiglagerung/keine unnötige Bewegung, eine moderate Flüssigkeitsgabe und eine Taucherärztliche Telefonberatung empfohlen.Die hyperbare Sauerstofftherapie (HBOT) ist bei schweren Dekompressionsunfällen unverändert ohne therapeutische Alternative. Als Behandlungsschema wird grundsätzlich eine HBOT bei 280 kPa empfohlen.
    Schlagwörter: diving accident ; decompression sickness ; decompression illness ; arterial gas embolism ; oxygen ; hyperbaric oxygen therapy ; Tauchunfall ; Dekompressionserkrankung ; arterielle Gasembolie ; Sauerstoff ; hyperbare Sauerstofftherapie ; ddc: 610
    Sprache: Englisch
    Materialart: article
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    GERMAN MEDICAL SCIENCE
  • 13
    facet.materialart.
    Unbekannt
    Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC07 /20230327/
    Details
    Publikationsdatum: 2023-03-27
    Beschreibung: The objective is to provide a comprehensive overview of the rapidly developing field of the current state of research on in vivo use of hypochlorous acid (HOCl) to aid infection prevention and control, including naso-pharyngeal, alveolar, topical, and systemic HOCl applications. Also, examples are provided of dedicated applications in COVID-19. A brief background of HOCl's biological and chemical specifics and its physiological role in the innate immune system is provided to understand the effect of in vivo applications in the context of the body's own physiological defense mechanisms.
    Beschreibung: Es wird ein umfassender Überblick über den aktuellen Stand der Forschung zum In-vivo-Einsatz von hypochloriger Säure (HOCl) zur Infektionsprävention und -bekämpfung gegeben. Der Schwerpunkt liegt auf nasalen, alveolären und topischen Anwendungen. Außerdem werden Beispiele für spezielle Anwendungen bei COVID-19 vorgestellt. Um die Wirkung von HOCl im Zusammenwirken mit körpereigenen physiologischen Abwehrmechanismen zu verstehen, werden die biologischen und chemischen Besonderheiten von HOCl und seiner physiologischen Rolle im humanen Immunsystem erläutert
    Schlagwörter: hypochlorous acid ; in vivo application ; HOCl chemistry ; innate immune response ; tissue compatibility ; infection control ; inhalation ; wound care ; disinfection ; Hypochlorige Säure ; In-vivo-Anwendung ; HOCl-Chemie ; physiologische Immunantwort ; Gewebeverträglichkei ; Infektionsprävention ; Inhalation ; Wundpflege ; Desinfektion ; ddc: 610
    Sprache: Englisch
    Materialart: article
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  • 14
    facet.materialart.
    Unbekannt
    Pseudomelanoma: occult intraocular foreign body mimicking choroidal melanoma (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC03 /20230130/
    Details
    Publikationsdatum: 2023-02-04
    Beschreibung: Purpose: To report an occult intraocular foreign body mimicking choroidal melanoma. Methods: Medical records and imagings of the patient were retrospectively reviewed.Case description: A 76-year-old male was referred to our ocular oncology clinic with a suspicious hyperpigmented retinal lesion in the left eye. Biomicroscopy showed aphakia and peripheral iridectomy in the left eye. Fundoscopy revealed a pigmented, slightly elevated lesion on the macula of the left eye surrounded by diffuse atrophy. B-scan ultrasonography showed a preretinal hyperechoic lesion with posterior shadowing. There was no choroidal mass in B-scan or optical coherence tomography (OCT) imaging. On further questioning, it was disclosed that the patient had been hit by an iron fragment in the left eye forty years ago.Conclusion: Choroidal melanoma is a vision- and life-threatening intraocular malignant tumour. Various neoplastic, degenerative, and inflammatory conditions can simulate choroidal melanoma. A previous history of penetrating ocular trauma should lead the surgeon to re-evaluate a diagnosis of melanoma.
    Schlagwörter: choroid hemorrhage ; choroid neoplasms ; choroidal neovascularization ; foreign bodies ; eye injuries ; Aderhautblutung ; Aderhautneoplasmen ; choroidale Neovaskularisation ; Fremdkörper ; Augenverletzungen ; ddc: 610
    Sprache: Englisch
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  • 15
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    Covid-19 vaccination acceptance and hesitancy among the Turkish adult population (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC01 /20230117/
    Details
    Publikationsdatum: 2023-01-18
    Beschreibung: Objective: The aim of this study was to determine the acceptance of Covid-19 vaccine among the Turkish adult population. Methods: A total of 2023 persons participated in this cross-sectional study between October 2020 and January 2021. The questionnaire, which was delivered via social media, was filled out by the participants over "Google Forms".Results: Questionnaire results showed that 68.7% of the participants might agree to vaccinated against COVID-19. According to univariate analysis, the age group of 50-59, urban residents, healthcare workers, non-smokers, and those with chronic diseases, those who were vaccinated against influenza, pneumonia, and tetanus were all willing to be vaccinated against COVID-19.Conclusions: It is very important to determine a community's willingness to be vaccinated against COVID-19 so that interventions can be made to solve related problems. Risk of exposure and importance of Prevention play a critical role in vaccination acceptance.
    Beschreibung: Zielsetzung: Ziel der Studie war es, die Akzeptanz der Covid-19 Impfung in der türkischen Erwachsenenbevölkerung zu ermitteln.Methode: An der Querschnittsstudie nahmen zwischen Oktober 2020 und Januar 2021 2023 Personen teil. Der Fragebogen, der über soziale Medien übermittelt wurde, wurde von den Teilnehmern über "Google Forms" ausgefüllt.Ergebnisse: 68,7% der Teilnehmer stimmen der Impfung gegen COVID-19 zu. Die univariate Analyse ergab, dass die Altersgruppe der 50- bis 59-Jährigen, Stadtbewohner, Beschäftigte im Gesundheitswesen, Nichtraucher und chronisch Kranke sowie diejenigen, die gegen Influenza, Lungenentzündung und Tetanus geimpft waren, alle bereit waren, sich gegen COVID-19 impfen zu lassen.Schlussfolgerung: Es ist wichtig, die Bereitschaft einer Gemeinschaft zu ermitteln, sich gegen COVID-19 impfen zu lassen, damit Maßnahmen zur Lösung der damit verbundenen Probleme ergriffen werden können. Das Expositionsrisiko und die Erkennung von Gefahren spielen eine entscheidende Rolle für die Akzeptanz der Impfung.
    Schlagwörter: Covid-19 ; vaccine ; risk ; protectionimmunization ; Covid-19 ; Impfstoff ; Risiko ; Schutz ; Impfung ; ddc: 610
    Sprache: Englisch
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  • 16
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    Besseres Hören mit neuen Verfahren - ein Rück- und Ausblick (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC02 /20230120/
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    Publikationsdatum: 2023-01-21
    Schlagwörter: ddc: 610
    Sprache: Deutsch
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  • 17
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    Mit Lichtstrahlen das Gehör wiederherstellen (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC01 /20230120/
    Details
    Publikationsdatum: 2023-01-21
    Beschreibung: When hearing fails, cochlear implants (CIs) provide most CI users with open speech understanding in quiet environments. CIs bypass the defective sensory organ and electrically stimulate the auditory nerve. The bottleneck of hearing rehabilitation with currently available CIs is their limitation in encoding spectral information resulting from the broad current spread from each electrode contact. Because light can be confined in space more conveniently, optogenetic stimulation of the auditory nerve represents a promising alternative. The development of optogenetic stimulation for future optical CIs requires efforts to design and characterize appropriate optogenetic actuators, viral gene transfer to neurons, and development of multichannel optical CIs. This review article reports the current status of optogenetic stimulation of the auditory pathway and recent breakthroughs in achieving high temporal precision and frequency resolution and in establishing multichannel optical CIs.
    Beschreibung: Wenn das Hören versagt, bieten Cochlea-Implantate (CIs) den meisten der CI-Träger ein offenes Sprachverstehen in ruhiger Umgebung. CIs umgehen das defekte Sinnesorgan und stimulieren den Hörnerv elektrisch. Der Flaschenhals der Hörrehabilitation mit aktuell verfügbaren CIs ist deren Limitierung bei der Kodierung spektraler Information, die sich aus der breiten Stromausbreitung von jedem Elektrodenkontakt ergibt. Weil Licht räumlich besser begrenzt werden kann, stellt die optische Stimulation des Hörnervs eine vielversprechende Perspektive für einen grundlegenden Fortschritt der CIs dar. Die Entwicklung der optogenetischen Stimulation für zukünftige optische CIs erfordert Anstrengungen zum Design und zur Charakterisierung geeigneter optogenetischer Aktuatoren, zum viralen Gentransfer auf die Neuronen sowie zur Entwicklung mehrkanaliger optischer CIs. Dieser Übersichtsartikel berichtet über den aktuellen Stand der optogenetischen Stimulation der Hörbahn und über die jüngsten Durchbrüche bei der Erzielung hoher zeitlicher Präzision und Frequenzauflösung sowie bei der Etablierung optischer Mehrkanal-CIs.
    Schlagwörter: ddc: 610
    Sprache: Deutsch
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  • 18
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    Ethanol is indispensable for virucidal hand antisepsis and without toxic risks in daily use (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC02 /20230123/
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    Publikationsdatum: 2023-01-24
    Beschreibung: The approval of ethanol by the Biocidal Products Regulation has been under evaluation since 2007 due to controversial opinions on the risk assessment. Because of this critical situation, 2022 a memorandum was published to verify whether the use of ethanol for hand antisepsis poses any hazard. On the basis of the memorandum a toxicological evaluation of ethanol-based hand rubs is given.
    Beschreibung: Die Bewertung von Ethanol als Biozid gemäß der Biozid-Verordnung wird seit 2007 aufgrund kontroverser Meinungen zur Risikobewertung geprüft. Wegen dieser kritischen Situation wurde 2022 ein Memorandum veröffentlicht, um zu überprüfen, ob die Verwendung von Ethanol zur Händedesinfektion eine Gefahr darstellt. Auf der Grundlage des Memorandums wird eine zusammenfassende toxikologische Bewertung Ethanol basierten Händedesinfektionsmittel gegeben.
    Schlagwörter: biocidal product regulation ; 1-propanol ; 2-propanol ; ethanol ; ethanol based hand rubs ; benefit-risk-assessment ; virucidal efficacy ; dermal absorption ; worker safety ; patient safety ; Biozid-Verordnung ; 1-Propanol ; 2-Propanol ; Ethanol ; Ethanol basierte Händedesinfektionsmittel ; Nutzen-Risiko-Bewertung ; Viruzidie ; dermale Resorption ; Mitarbeitersicherheit ; Patientensicherheit ; ddc: 610
    Sprache: Englisch
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  • 19
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    Online-Kunsttherapie in Zeiten von Corona? Eine Darstellung digitaler Kunsttherapie am Beispiel Spanien (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Journal of Arts Therapies; VOL: 5; DOC01 /20230125/
    Details
    Publikationsdatum: 2023-01-26
    Beschreibung: Due to the challenges posed by the COVID-19 pandemic, it has become essential to explore new and innovative ways to conduct art therapy interventions. Digital art therapy is a new way of therapy for both, art therapists and clients. In Spain, concepts for digital art therapy have already been developed and implemented not only by art therapists, but also by organisations and universities. These concepts are aimed at art therapists as part of clinical supervision, as well as at clients receiving art therapy. This paper looks at the rapidly growing area of digitally conducted art therapies and the requirements in relation to infrastructure and security, as well as the challenges and opportunities of this new way of working.
    Beschreibung: Sowohl für Kunsttherapeut:innen als auch für die Teilnehmenden ist die digitale Kunsttherapie ein noch ungewohntes Terrain. Aufgrund der COVID-19 Pandemie war es jedoch notwendig, neue und innovative Ansätze zur Durchführung von Kunsttherapie zu erarbeiten. In Spanien werden nicht nur von Kunsttherapeut:innen, sondern auch von Organisationen und Hochschulen Konzepte für die digitale Kunsttherapie durchgeführt. Diese richten sich sowohl an Kunsttherapeut:innen in Form von Supervision und Weiterbildung, als auch an Klient:innen in Form einer Therapiemaßnahme. Die vorliegende Arbeit befasst sich mit diesem rasant wachsenden Arbeitsfeld im Bereich Künstlerischer Therapien und stellt mögliche Setting- und Rahmenbedingungen, Herausforderungen sowie Möglichkeiten für die digitale Kunsttherapie zusammenfassend dar.
    Schlagwörter: art therapies ; digital space ; online art therapy ; Spain ; COVID-19 ; Künstlerische Therapien ; digitaler Raum ; Online-Kunsttherapie ; Spanien ; COVID-19 ; ddc: 610
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  • 20
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    Compliance assessment regarding the PVC management on normal wards of a university hospital (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC04 /20230127/
    Details
    Publikationsdatum: 2023-01-28
    Beschreibung: Objective: The risk of peripheral venous catheter (PVC) infections in inpatients is often underestimated, even if it is lower than that for central venous catheters. Guidelines for the prevention of PVC-associated infections describe the evidence-based management of PVCs. The aims of this study were the development of standardized methods for compliance assessment regarding PVC management and the evaluation of self-reported knowledge and implementations among healthcare providers regarding PVC care.Method: We developed a checklist based on the recommendation of the Commission of Hospital Hygiene and Infection Prevention at the Robert Koch Institute (KRINKO) Berlin for the standardized evaluation of PVC management. The following parameters were collected and evaluated: condition of the puncture site, condition of the bandage, presence of an extension set, presence of a plug, and documentation. The checklist was applied in 14 normal wards in 2019. After feedback of the ward staff on the results, it was applied again in 2020 in the same wards. For retrospective data analysis, we used a newly developed PVC-quality index. After the second evaluation in 2020, we carried out an anonymous survey among the healthcare providers.Results: The evaluation of 627 indwelling PVCs showed a significant increase in compliance related to the presence of an extension set (p=0.049) and documentation (p〈0.001) in the 2nd year. The quality index increased in 12 out of 14 wards. The participants of the survey were aware of the in-house standard "Prevention of vascular catheter-associated infections", with a mean score of 4.98 on a Likert scale (1=not aware, 7=completely aware). The main barrier to implementation of the preventive measures was the time factor. Survey participants were more aware of PVC placement than PVC care.Conclusion: The PVC quality index is a valuable tool for the assessment of compliance regarding PVC management in daily practice. Feedback from the ward staff on the results of compliance assessment improves PVC management, but the outcome is very heterogeneous.
    Beschreibung: Zielsetzung: Das Infektionsrisiko von peripheren Venenkathetern (PVK) bei stationären Patienten wird, auch wenn es niedriger ist als das von zentralen Venenkathetern, häufig unterschätzt. Leitlinien zur Prävention von PVK-assoziierten Infektionen beinhalten Evidenz-basierte Maßnahmen zur Anlage, Pflege und Nutzung von liegenden PVK. Ziel dieser Studie war, ein Verfahren zur standardisierten Bewertung der Compliance im Umgang mit liegenden PVK zu entwickeln und zu testen. Außerdem sollte eine Selbsteinschätzung des Personals zu Kenntnis und Umsetzung der Präventionsmaßnahmen erhoben werden.Methode: Basierend auf den KRINKO-Empfehlungen wurde eine Checkliste zur standardisierten Bewertung der Umsetzung von Präventionsmaßnahmen bei liegenden PVK entwickelt. Folgende Parameter wurden erhoben und bewertet: Zustand der Punktionsstelle, Zustand des Verbands, Vorhandensein eines Extensionssets, Verschluss, Nutzung und Dokumentation der Maßnahmen. Die Checkliste wurde erstmals im Jahr 2019 auf 14 Normalstationen angewendet und nach Feedback der Ergebnisse erneut im Jahr 2020 auf denselben Stationen eingesetzt. Mithilfe eines neu entwickelten PVK-Qualitätsindex erfolgte ein retrospektiver Vergleich. Nach der 2. Bewertung wurde eine anonyme Mitarbeiterbefragung mittels Fragebogen durchgeführt.Ergebnisse: Bei der Bewertung von 627 liegenden PVK zeigte sich eine signifikante Steigerung der Compliance bezogen auf das Vorhandensein eines Extensionssets (p=0,049) und die Dokumentation (p〈0,001) im 2. Jahr. Der Qualitätsindex ist auf 12 der 14 beobachteten Stationen gestiegen. Die Bekanntheit einzelner Maßnahmen des hausinternen Standards "Prävention gefäßkatheterassoziierter Infektionen" wurde mit dem Mittelwert 4,98 von 7 auf einer Likert-Skala angegeben; als einziges Hindernis in der Umsetzung konnte der Faktor Zeit identifiziert werden. Maßnahmen bei PVK-Anlage waren zu einem höheren Anteil bekannt als Maßnahmen der PVK-Pflege. Fazit: Der PVK-Qualitätsindex ist erfolgreich angewendet worden und ist geeignet, die PVK-bezogene Compliance standardisiert zu erheben. Feedback der Compliance im Umgang mit PVK hat diese verbessert, aber der Effekt ist sehr heterogen.
    Schlagwörter: catheter related infection ; peripheral venous catheter ; compliance assessment ; compliance self-assessment ; peripheral venous catheter quality index ; Katheter-assoziierte Infektion ; peripherer Venenkatheter ; Compliance-Bewertung ; Compliance-Selbsteinschätzung ; PVK-Qualitätsindex ; ddc: 610
    Sprache: Englisch
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  • 21
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    Safe injection, infusion and medication-vial practices at a tertiary care centre: a quality improvement initiative (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC03 /20230127/
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    Publikationsdatum: 2023-01-28
    Beschreibung: Introduction: There is a risk of transmission of viruses and microbial pathogens during routine health care procedures due to improper injection, infusion, and medication-vial practices. Unsafe practices lead to outbreaks of infection resulting in unacceptable and devastating events in patients. The present study was undertaken to assess the compliance of nurses with safe injection and infusion practices in our hospital and to identify staff education requirements in relation to the safe-injection and infusion practices policy.Methods: Baseline data were collected and high risk areas were identified on this basis, a quality improvement project was implemented by infection control team. FOCUS PDCA methodology was used to conduct the improvement process. The study was performed from March to September 2021. An audit checklist based on the CDC guidelines was used for monitoring compliance with safe injection and infusion practices. Results: Poor compliance with safe injection and infusion practices in few clinical areas at baseline. During the pre-intervention period, non-compliance was mainly seen with the following elements: aseptic technique (79%), rubber septum disinfected with alcohol (66%), labelling of all IV lines and medications with date and time (83%), compliance with multidose-vial policy (77%), use of multidose vials for single patient (84%), safe disposal of sharps (84%), using trays instead of clothing/pockets to carry medications (81%).There was significant improvement in compliance with the following elements of safe injection and infusion practices in the post-intervention period: aseptic technique (94%), rubber septum disinfected with alcohol (83%), compliance with multidose-vial policy (96%), use of multidose vials for single patient only (98%), safe disposal of sharps (96%).Conclusion: Adherence to safe injection and infusion practices is very important to prevent outbreaks of infection in health care settings.
    Beschreibung: Einführung: Im Fall unsachgemäßer Injektion, Infusion und fehlerhaften Umgangs mit Medikamenten besteht das Risiko der Übertragung von Viren und Mikroorganismen. Fehlerhafte Praktiken können zum Ausbruch von Infektionen mit drastischen Folgen für die Patienten führen. Die vorliegende Studie wurde durchgeführt, um die Einhaltung sicherer Injektions- und Infusionspraktiken in unserem Krankenhaus durch das Pflegepersonal zu bewerten und den Schulungsbedarf des Personals zu ermitteln.Methoden: Die Analyse der Ausgangssituation ergab eine schlechte Einhaltung sicherer Injektions- und Infusionspraktiken in einigen klinischen Bereichen. In den identifizierten Bereichen mit hohem Risiko wurde vom Infektionskontrollteam ein Qualitätsverbesserungsprojekt etabliert. Zur Durchführung wurde die FOCUS PDCA-Methode verwendet. Die Studie erstreckte sich von März bis September 2021. Zur Überwachung der Einhaltung sicherer Injektions- und Infusionspraktiken wurde eine Audit-Checkliste auf der Grundlage der CDC-Richtlinien verwendet.Ergebnisse: Während der Zeit vor der Intervention wurde die Nichteinhaltung hauptsächlich in Bezug auf folgende Elemente festgestellt: Aseptische Technik (79%), mit Alkohol desinfiziertes Gummiseptum (66%), Kennzeichnung aller Infusionsleitungen und Medikamente mit Datum und Uhrzeit (83%), Einhaltung der Richtlinie für Mehrdosisfläschchen (77%), Verwendung von Mehrdosisfläschchen für einen einzelnen Patienten (84%), sichere Entsorgung von scharfen Gegenständen (84%), Tragen von Medikamenten in Kleidung/Taschen anstatt auf dem Tablett (81%).Es gab eine signifikante Verbesserung bei der Einhaltung der folgenden Elemente sicherer Injektions- und Infusionspraktiken nach der Intervention: Aseptische Technik (94%), mit Alkohol desinfiziertes Gummiseptum (83%), Einhaltung der Richtlinie für Mehrdosis-Durchstechflaschen (96%), Verwendung von Mehrdosis-Durchstechflaschen für einen einzelnen Patienten (98%), sichere Entsorgung scharfer Gegenstände (96%).Schlussfolgerung: Die Einhaltung sicherer Injektions- und Infusionspraktiken ist unerlässlich, um Ausbrüche nosokomialer Infektionen zu verhindern.
    Schlagwörter: safe injection and infusion practices ; aseptic techniques ; single syringe ; single needle ; single patient ; multidose-vial policy ; labelling of IV lines ; safe disposal of sharps ; sichere Injektions- und Infusionspraktiken ; aseptische Technik ; Einzelspritze ; Einzelnadel ; Einzelpatient ; Mehrdosisfläschchen ; Kennzeichnung von Infusionsleitungen ; sichere Entsorgung scharfer Gegenstände ; ddc: 610
    Sprache: Englisch
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  • 22
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    A rare cause of recurrent subconjunctival hemorrhage: ocular vicarious menstruation (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC05 /20230130/
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    Publikationsdatum: 2023-01-31
    Beschreibung: Purpose: Vicarious menstruation is cyclical bleeding in extra-uterine locations that occurs during menstruation or within 48 h of its onset. We aim to present a 43-year-old female with ocular vicarious menstruation, its treatment, and a review of other published cases of ocular vicarious menstruation. Case presentation: A 43-year-old Caucasian female presented with a 15-year history of recurrent monthly unilateral subconjunctival hemorrhage. The episodes were cyclical and coincided with the onset of menses, lasting for approximately 10 to 14 days. Slit-lamp examination of the right eye showed nasally located subconjunctival hemorrhage. Detailed laboratory findings, including parameters for various hematological disorders, were normal. A follow-up examination 2 weeks later showed that the subconjunctival hemorrhage in the right eye was completely resolved. The patient was prescribed the oral contraceptive levonorgestrel/ethinyl estradiol and marked improvement at the recurrences of subconjunctival hemorrhage was noted during subsequent menses.Conclusion: Ocular vicarious menstruation is among the rarest causes of recurrent subconjunctival hemorrhage. A therapeutic trial of oral contraceptive should be considered in patients that present with ocular vicarious menstruation.
    Schlagwörter: recurrent subconjunctival hemorrhage ; ocular vicarious menstruation ; extrauterine bleeding ; oral contraceptive pills ; ddc: 610
    Sprache: Englisch
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  • 23
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    Surgically induced scleral necrosis associated with concomitant tuberculosis infection: a diagnostic challenge (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC04 /20230130/
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    Publikationsdatum: 2023-01-31
    Beschreibung: Objective: Surgically induced scleral necrosis (SISN) is a potentially blinding sequela that may occur after any ocular procedure. SISN in the context of active tuberculosis is seldom seen. We report a case of a patient with asymptomatic tuberculosis who developed SISN after pterygium surgery.Methods: A 76-year-old Mexican-mestizo woman from Veracruz, Mexico, was referred to our clinic because of severe disabling pain and scleral thinning in her right eye.Results: Tubercular-related SISN was finally diagnosed and managed successfully with antitubercular therapy, topical and systemic corticosteroidsConclusion: Tuberculosis must be considered as a differential diagnosis of high-risk patients in the context of refractory SISN in endemic countries.
    Schlagwörter: antitubercular therapy ; infectious scleritis ; necrotizing scleritis ; ocular tuberculosis ; pterygium surgery ; scleral inflammation ; surgically induced scleral necrosis ; ddc: 610
    Sprache: Englisch
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  • 24
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    Vorteile des direkten akustischen Streamens beim Telefonieren bimodal versorgter Hörsystemnutzer (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC03 /20230131/
    Details
    Publikationsdatum: 2023-02-01
    Beschreibung: The present study investigated whether direct bilateral streaming on cochlea implant (CI) and hearing aid provides bimodal hearing instrument users with an advantage when making phone calls via smartphone compared with previously used methods.In two laboratory tests, 22 experienced CI listeners (mean age 50.8±18.6 years), fitted bimodally with a Cochlear N7 processor, as well as a GN ReSound hearing aid, were tested with their own previously used, mostly unilateral phone use (reference condition) and with MFi technology (test condition). In the test condition, signals were directly streamed from a smartphone to both hearing instruments. Speech intelligibility, subjectively perceived listening effort, each in interfering noise, and subjective ratings (including sound, usability via System Usability Scale, SUS) were obtained as key measures of benefit. The results showed a trend towards improved speech intelligibility, as well as a significantly lower listening effort with bilateral streaming compared to conventional telephone use in both the measurement and the questionnaire data. In terms of usability, bilateral streaming also resulted in better ratings compared to the reference.
    Beschreibung: In der vorliegenden Studie wurde untersucht, ob das direkte bilaterale Streamen in Cochlea-Implantat (CI) und Hörgerät (HG) bimodalen Hörsystemnutzern einen Vorteil beim Telefonieren mit dem Smartphone im Vergleich zu bisher genutzten Verfahren bringt. In zwei Labortests wurden 22 erfahrene CI-Träger (Durchschnittsalter 50,8±18,6 Jahre), die bimodal mit einem N7 Prozessor der Firma Cochlear sowie einem GN ReSound Hörgerät versorgt waren, mit ihrer eigenen bisher genutzten, meist unilateralen Telefonnutzung (Referenz-Kondition) sowie mit MFi-Technologie (Test-Kondition) getestet. In der Test-Kondition wurde direkt von einem Smartphone auf beide Hörsysteme gestreamt. Als wesentliche Messgrößen des Benefits wurden die Sprachverständlichkeit, die subjektiv empfundene Höranstrengung, jeweils im Störgeräusch, und subjektive Bewertungen (u.a. zu Klang, Gebrauchstauglichkeit über System Usability Scale, SUS) erfasst. Die Ergebnisse ergaben eine tendenziell verbesserte Sprachverständlichkeit, sowie eine signifikant geringere Höranstrengung bei beidseitigem Streaming im Vergleich zur herkömmlichen Telefonnutzung in sowohl den Mess-, als auch den Fragebogendaten. Im Hinblick auf Gebrauchstauglichkeit führte das beidseitige Streaming, verglichen mit der Referenz, ebenfalls zu besseren Bewertungen.
    Schlagwörter: cochlear implant ; MFi ; streaming ; telephoning with CI ; Cochlea-Implantat ; MFi ; Streamen ; Telefonieren mit CI ; ddc: 610
    Sprache: Deutsch
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  • 25
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    Staged limbal stem cell transplantation and keratoplasty surgeries as a treatment for gelatinous drop-like corneal dystrophy (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC02 /20230130/
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    Publikationsdatum: 2023-01-31
    Beschreibung: Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that has been associated with mutations in the TACSTD2 (M1S1) gene, which is normally expressed in corneal epithelial cells. GDLD is characterized by progressive deposition of amyloid in the corneal stroma with rapid recurrence in grafts after penetrating keratoplasty. We report of case of a patient with GDLD treated bilaterally with staged limbal stem cell transplantation and penetrating keratoplasty that resulted in long-term control of his disease. This case demonstrates that staged allogenic limbal stem cell transplantation, before or after penetrating keratoplasty, can be used to restore vision long-term in GDLD patients.
    Schlagwörter: gelatinous drop-like corneal dystrophy (GDLD) ; penetrating keratoplasty (PKP) ; allogeneic limbal stem-cell transplantation ; ddc: 610
    Sprache: Englisch
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  • 26
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    Multimodal imaging in a case of bilateral astrocytic hamartoma with retinitis pigmentosa (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC01 /20230130/
    Details
    Publikationsdatum: 2023-01-31
    Beschreibung: Astrocytic hamartoma is a benign glial tumor. It may be associated with tuberous sclerosis and can also be found incidentally on retinal examination as an isolated presentation. Here, we describe multimodal imaging characteristics of astrocytic hamartoma in a patient with retinitis pigmentosa. Spectral domain optical coherence tomography of both eyes showed moth-eaten optically empty spaces and hyperreflective dots along with foveal thinning. Multicolor image highlighted mulberry appearance of the lesion with green shift signifying elevated lesion. In infrared reflectance, lesion was hyporeflective with its margins well delineated. Green reflectance and blue reflectance highlighted calcification as multiple hyperreflective dots. Autofluorescence showed typical hyperautofluorescence.
    Schlagwörter: astrocytic hamartoma ; multicolor imaging ; retinitis pigmentosa ; ddc: 610
    Sprache: Englisch
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  • 27
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    Musiktherapie - neu definiert (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Journal of Arts Therapies; VOL: 5; DOC02 /20230228/
    Details
    Publikationsdatum: 2023-02-28
    Beschreibung: The definition of a therapeutic discipline provides an important position-fixing and offers orientation for patients, interested parties and professional actors in health care. The definition of music therapy (MT) serves both the self-portrayal of music therapists and the professional classification in the institutions of the public health care system. Thus it contributes decisively to the professional political profiling. There is currently no definition of music therapy in Germany that fits well into the German health system.In this article, different definitions are presented and critically questioned. Against the background of new developments within MT, the necessity for a new definition is shown. This is presented and explained in its conceptual components.
    Beschreibung: Die Definition einer therapeutischen Disziplin leistet eine wichtige Standortbestimmung und bietet Orientierung für Patient:innen, Interessent:innen und professionelle Akteure der Gesundheitsversorgung. Die Definition von Musiktherapie (MT) dient sowohl der Selbstdarstellung von Musiktherapeut:innen, als auch der fachlichen Einordnung in die Institutionen des öffentlichen Gesundheitswesens. Damit trägt sie entscheidend zur berufspolitischen Profilierung bei. Es gibt aktuell in Deutschland keine im deutschen Gesundheitssystem gut anschlussfähige Definition von Musiktherapie. In diesem Artikel werden verschiedene Definitionen dargestellt und kritisch hinterfragt. Vor dem Hintergrund von Neuentwicklungen innerhalb der MT wird die Notwendigkeit für eine neue Definition aufgezeigt. Diese wird vorgestellt und in ihren Begriffsbausteinen erläutert.
    Schlagwörter: definition ; music therapy ; intervention ; methods ; Definition ; Musiktherapie ; Intervention ; Methodik ; ddc: 610
    Sprache: Deutsch
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  • 28
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    Wissenschaft. Nah am Menschen - 68. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) e.V. (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 19; DOC13 /20230912/
    Details
    Publikationsdatum: 2023-09-12
    Schlagwörter: ddc: 610
    Sprache: Deutsch
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  • 29
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    Gesundheitskioske als Technologie für bürgerzentrierte Gesundheits-IT: Werden sie genutzt und wenn nein, warum nicht? (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 19; DOC12 /20230912/
    Details
    Publikationsdatum: 2023-09-12
    Beschreibung: Health kiosks are basically a low-threshold opportunity for communication between citizens and other actors in the healthcare system as well as for information on health-related issues. The aim of the study was to record the use of health kiosks in pharmacies by means of a quantitative long-term survey and to determine the reasons for (non-)use by means of a qualitative in-depth analysis. Overall, usage parameters were recorded over 25 months in log files of up to 145 pharmacies. In addition, 92 customers of four high-usage pharmacies were interviewed in qualitative short interviews regarding the reasons for use or non-use. The results of the long-term study showed that the health kiosks were used 1-2 times a day at best, but more likely only 1-2 times a week. The reasons for non-use were due to the interaction of different factors, including accessibility and usefulness, but also the social environment. It can be concluded that identifying the reasons for (non-)use is an important step towards allowing the potential of health kiosks to unfold if they are to be used in a targeted manner within the framework of the digitalisation strategy of the Federal Ministry of Health.
    Beschreibung: Gesundheitskioske stellen grundsätzlich eine niedrigschwellige Möglichkeit für die Kommunikation zwischen Bürgern und weiteren Akteuren im Gesundheitswesen sowie für die Information zu gesundheitsrelevanten Fragestellungen dar. Ziel der Studie war es, über eine quantitative Langzeiterhebung die Nutzung von Gesundheitskiosken in Apotheken zu erfassen und über eine qualitative Tiefenanalyse die Gründe für die (Nicht)-Nutzung zu ermitteln. Insgesamt wurden Nutzungsparameter über 25 Monate in Logdateien von bis zu 145 Apotheken festgehalten. Darüber hinaus wurden 92 Kunden von vier nutzungsstarken Apotheken in qualitativen Kurzinterviews hinsichtlich der Gründe der Nutzung bzw. Nichtnutzung befragt. Die Ergebnisse der Langzeitstudie zeigen, dass die Gesundheitskioske im besten Falle 1-2 mal pro Tag, eher aber nur 1-2 mal pro Woche genutzt wurden. Die Gründe für die Nicht-Nutzung wurden durch das Zusammenspiel unterschiedlicher Faktoren bedingt, hierzu zählten u.a. die Zugänglichkeit und die Nützlichkeit, aber auch das soziale Umfeld. Zusammenfassend lässt sich feststellen, dass die Identifizierung der Gründe für die (Nicht-)Nutzung ein wichtiger Schritt ist, damit sich das Potential von Gesundheitskiosks entfalten kann, wenn sie im Rahmen der Digitalisierungsstrategie des Bundesministeriums für Gesundheit zum gezielten Einsatz kommen sollen.
    Schlagwörter: self-service technology ; SST ; health kiosk ; usage ; usefulness ; Selbstbedienungstechnologien ; Gesundheitskiosk ; Nutzung ; Nutzen ; ddc: 610
    Sprache: Deutsch
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  • 30
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    Wissenschaftsausbildung im Medizinstudium: Das Oldenburger Datenanalyseprojekt als Umsetzungsbeispiel [Lessons learned] (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 19; DOC11 /20230912/
    Details
    Publikationsdatum: 2023-09-12
    Beschreibung: Introduction: According to the Master Plan 2020, science education will play a critical role in future medical curricula. Science modules have already been implemented at many locations. Other medical faculties will follow in the next few years, as legislation is expected to make recommendations of the national competence-based learning objectives curriculum for medicine (NKLM) mandatory. This article aims to present an implementation example from epidemiology and biometry as a contribution to the didactic discussions within the data sciences in medicine. Project description: We report on our experiences with a data analysis project for second-year medical students, which has been compulsory at the Faculty of Medicine and Health Sciences since 2019. The project is intended to train the scientific skills required from the subjects of epidemiology and biometry for student research projects. Emphasis is placed on responsible data handling, transparency, and reproducibility. For example, the writing of a statistical analysis plan is required prior to data access. Improved standardization of materials, optional use of the English language, and digital support will be implemented to help manage the project when student numbers increase. Discussion: The experience from five years is very positive, although a formal evaluation of the learning success is still pending. Current challenges concern staffing, additional time and supervision requirements for those students who do statistical programming with R, and improved integration into the medical curriculum.
    Beschreibung: Einleitung: Wissenschaftsausbildung wird im Medizinstudium gemäß Masterplan 2020 künftig einen höheren Stellenwert einnehmen. An vielen Standorten sind wissenschaftliche Curricula bereits umgesetzt. Andere Fakultäten werden voraussichtlich in den nächsten Jahren nachziehen und dabei auch die Empfehlungen des Nationalen Kompetenzbasierten Lernzielkatalogs Medizin (NKLM) zu berücksichtigen haben. Ziel dieses Artikels ist die Darstellung eines Umsetzungsbeispiels aus den Fächern Epidemiologie und Biometrie als Beitrag zur fachlich-didaktischen Diskussion. Projektbeschreibung: Wir berichten von unseren Erfahrungen mit einem seit 2019 an der Fakultät für Medizin und Gesundheitswissenschaften verpflichtenden Datenanalyseprojekt für Medizinstudenten im zweiten Studienjahr. Das Projekt soll die aus den Fächern Epidemiologie und Biometrie benötigten wissenschaftlichen Kompetenzen für spätere eigene Forschungsprojekte trainieren. Dabei wird besonderer Wert auf verantwortungsvollen Umgang mit Daten, Transparenz und Reproduzierbarkeit gelegt. Beispielsweise stellt ein von den Studenten zu erstellender statistischer Analyseplan eine notwendige Voraussetzung des Datenzugangs dar. Parallel werden eine zunehmende Standardisierung der Betreuung, wahlweise Nutzung von Englisch und digitale Unterstützung umgesetzt, damit das Projekt perspektivisch auch bei ansteigenden Studentenzahlen zu bewältigen ist. Diskussion: Die Erfahrungen aus bisher 5 Jahren sind sehr positiv, wobei eine formale Evaluation des Lernerfolgs noch aussteht. Das Projekt ist sowohl für die Studenten als auch für Betreuer und Dozenten aufwändiger als derzeit abgebildet werden kann. Aktuelle Herausforderungen bestehen vor allem hinsichtlich personeller Ausstattung, zusätzlichen Zeit- und Betreuungsbedarfs derjenigen Studenten, die sich für eigene statistische Programmierung mit R entscheiden, und einer Optimierung der curricularen Einbindung.
    Schlagwörter: science education ; medical curriculum ; teaching goals ; epidemiology and biometry ; Wissenschaftsausbildung ; Medizinstudium ; Lernzielkatalog ; Epidemiologie und Biometrie ; ddc: 610
    Sprache: Deutsch
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  • 31
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    Technological Advancement in Algal Biofuels Production (2023)
    Singapore : Springer Nature Singapore
    Details
    Schlagwörter: Microbiology. ; Biology—Technique. ; Biotechnology. ; Microbiology. ; Biological Techniques. ; Biotechnology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This edited book presents all feasible approaches to improve technology of algal biofuels production at both qualitative and quantitative front. The book’s focus in on enhancing mass scale production of algae based biofuels by addressing technological issues and filling the existing gaps to make it smooth for practical as well as commercial implementation. The book also explores in depth analysis of various issues other than technology and related to improve technological significance for practical biofuels production from algae. Low cost strategies and higher mass production is one of the most sounding agenda of the book. The book also evaluates enlighten various sustainable algal biofuels options which are close towards commercial application along with their green future prospect. Societal and environment friendly approach even for commercial application has also been discussed in book. This is a useful reading material for researchers and students of biofuels and reneable energy. .
    Materialart: Online-Ressource
    Seiten: XI, 295 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811968068
    Serie: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-19-6806-8
    DOI: 10.1007/978-981-19-6806-8
    Sprache: Englisch
    Anmerkung: Chapter 1. Biotechnological approaches to enhance algae biofuel production -- Chapter 2. The use of omics technologies, random mutagenesis, and genetic transformation techniques to improve algae for biodiesel industry -- Chapter 3. Algal butanol production: recent developments -- Chapter 4. Algal synthesis of gold nanoparticles: applications in bioenergy -- Chapter 5. Challenges assessment in economic Algal biofuel Production -- Chapter 6. Influence of culture conditions on the microalgae biomass and lipid accumulation -- Chapter 7. Advanced genetic approaches towards custom design microalgae for fourth-generation biofuels -- Chapter 8. Algal biofuel production from municipal waste waters -- Chapter 9. Positive influence and future perspective of marine alga on biofuel production -- Chapter 10. Algae bacterial mixed culture for waste to wealth conversation: a case study.
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  • 32
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    Paleoneurology of Amniotes : New Directions in the Study of Fossil Endocasts (2023)
    Cham : Springer International Publishing
    Details
    Schlagwörter: Evolution (Biology). ; Zoology. ; Anatomy. ; Evolutionary Biology. ; Paleontology. ; Zoology. ; Anatomy.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: TThis book presents a detailed examination of the current state of knowledge in the field of paleoneurology in the main amniote groups (reptiles, birds and mammals), and advances resulting from new non-invasive technologies. The study of fossil endocasts is an area of considerable current interest, and has long been central to our understanding of the evolution of the brain, development of senses and behavioral adaptations in diverse vertebrate groups and across vertebrates as a whole. Recent advances in non-invasive imaging have significantly increased the number of fossil taxa for which brain morphology is known, and it may now be possible to quantitatively analyze the relative size of brain regions. Providing a general overview of current perspectives and problems in evolutionary neuroanatomy, this book is intended for a wide range of readers, including undergraduate and graduate students, teachers, and anyone with a special interest in paleoneurology. It is also useful as supplementary reading for courses in digital anatomy, vertebrate comparative anatomy, computed morphometrics, paleontology, neurology and radiology as well as evolution programs.
    Materialart: Online-Ressource
    Seiten: XX, 840 p. 171 illus., 123 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031139833
    URL: https://doi.org/10.1007/978-3-031-13983-3
    DOI: 10.1007/978-3-031-13983-3
    Sprache: Englisch
    Anmerkung: PART 1: FOSSIL ENDOCASTS IN REPTILES AND BIRDS -- Chapter 1 - Onto land and back into water: basal diapsids and marine reptiles -- Chapter 2 - Sauropterygia and Ichthyopterygia: Paleoneurology of secondarily aquatic reptiles -- Chapter 3 - Contrasting brains and bones: implications for turtle paleoneurology -- Chapter 4 - Approaches to the Paleoneurology of Lepidosauromorpha.-Chapter 5 - Paleoneuroanatomy of Triassic archosauriforms and pseudosuchians -- Chapter 6 - Paleoneurology of Crocodylomorpha -- Chapter 7 - Neurosensory evolution in the pterosaurs -- Chapter 8 - Paleoneurology of dinosaur endocasts: past, present, and future research -- Chapter 9 - The evolution of bird brain -- PART 2: FOSSIL ENDOCASTS IN MAMMALS -- Chapter 10 - Paleoneurology of stem and basal Mammalia -- Chapter 11 - Evolution of the brain and sensory structures in monotremes/Evolution of the brain and sensory structures in marsupials -- Chapter 12 - Early evolution of the brain in Primates and their close kin -- Chapter 13 - The brain of condylarthra and extinct Cetartiodactyla -- Chapter 14 - Sirenia fossil endocranial casts: history and evolution -- Chapter 15 - Paleoneurology of the Proboscidea (Mammalia, Afrotheria): insight from the brain endocast, bony labyrinth and infraorbital canal -- Chapter 16 - North American and South American Fossil Rodents: Cranial endocasts of extinct rodents and brain evolution -- Chapter 17 - Parallel patterns in carnivore brain evolution/South American Fossil Carnivorans: Auditory Region of Ursidae and Cranial Endocast of Procyonidae -- Chapter 18 - The Cranial Endocast and Inner Ear Anatomy of Extinct Cingulates -- Chapter 19 - The endocranial cavities of Folivora (Mammalia, Xenarthra): insights from the brain cavity, bony labyrinth and cranial sinuses -- Chapter 20 - Cranial Endocasts and Inner Ear of Notostylopidae and Typotheria/Endocranial Morphology of Toxodontians (Mammalia, Notoungulata) and Brain Evolution in Paleogene Notoungulates -- Chapter 21 - Digital and Natural Cranial Endocasts of Macraucheniidae (Mammalia, Litopterna): Brain and Frontal Sinuses.
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  • 33
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    Biomarkers in Diabetes (2023)
    Cham : Springer International Publishing
    Details
    Schlagwörter: Biochemical markers. ; Medicine—Research. ; Biology—Research. ; Metabolism—Disorders. ; Pharmacology. ; Biomarkers. ; Biomedical Research. ; Metabolic Disease. ; Pharmacology.
    In: Springer Nature eReference
    Beschreibung / Inhaltsverzeichnis: This handbook focuses specifically on biomarkers in diabetes and provides a comprehensive understanding of this field. Readers will gain deep insights into bioinformatics and network analysis of biomarkers in diabetes, and will learn about circulating biomarkers in body fluids and specific pathological features of diabetes. Various animal models in diabetes research are also presented. In addition, like the previous volumes in this large reference series, the book provides a comprehensive look at genetics, cellular, and histological variables. The goal of this handbook is to provide information on markers of this disease to facilitate diagnosis, introduce new technologies, and ultimately improve health. It is a must for researchers as well as advanced students and physicians in the field of diabetes and biomarker research and application.
    Materialart: Online-Ressource
    Seiten: 139 illus., 108 illus. in color. eReference. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031080142
    Serie: Biomarkers in Disease: Methods, Discoveries and Applications,
    URL: https://doi.org/10.1007/978-3-031-08014-2
    DOI: 10.1007/978-3-031-08014-2
    Sprache: Englisch
    Anmerkung: Bioinformatics and biomarkers for diabetes -- Network analysis of biomarkers un diabetes.-Biomarkers of insulin action .-Circulating and body fluid biomarkers -glucose.-Fructosamine as a glycaemic marker: features and applications.-Postload plasma glucose and oral glucose tolerance tests (OGTT): applications -- Circulating and body fluid biomarkers -impact of diabetes on pathology -- Biomarkers of diet in relation to diabetes: 5-CIS-, trans-and total lycopene -- Fatty Acid Biomarkers and Type 2 Diabetes -- Biomarkers of retina-related disease in diabetes.-Biomarkers of diabetes-induced nephropathy -- Biomarkers of atherosclerosis in diabetes mellitus -- Advanced glycation end products as biomarkers in diabetes -- Biomarkers of vascular injury in diabetes -- Amino acids as a biomarkers in diabetes .-Adiponectin-leptin ratio and diabetes -- Plasma omentin-1 as a biomarker in type 2 diabetes -- Serpin A12 as a type 2 diabetes biomarker.-Circulating Hsp90 as a potential biomarker of beta cell autoimmunity in type 1 diabetes.-CUBN variants, HES1, CDC73 and GRM5 as biomarkers in diabetes.-Biomarker polymorphisms and diabetic patients -- Epigenetics and 5-Hydroxymethylcytosines as a biomarker in type 2 diabetes. - Longevity biomarkers and applications to diabetes. .
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  • 34
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    T-Cell Development : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Immunology. ; Cancer. ; Immunology. ; Cancers.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This second edition volume provides new and updated chapters detailing simple and accessible experiment protocols to explore thymus biology. Chapters are divided into three parts presenting short reviews, analysis strategies, protocols for cell preparation, flow cytometry analyses, Innate Lymphoid Cells (ILC), mouse T-cell development, antigen receptor-less cousins of T cells, bone marrow chimeras, thymic stroma, and multiple aspects of thymocyte biology. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T-Cell Development: Methods and Protocols, Second Edition aims to be a useful practical guide to help readers overcome obstacles associated with experimental approaches of T-cell development.
    Materialart: Online-Ressource
    Seiten: XI, 384 p. 76 illus., 41 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9781071627402
    Serie: Methods in Molecular Biology, 2580
    URL: https://doi.org/10.1007/978-1-0716-2740-2
    DOI: 10.1007/978-1-0716-2740-2
    Sprache: Englisch
    Anmerkung: A beginner’s guide to T cell development -- Revelations in thymic epithelial cell biology and heterogeneity from single cell RNA sequencing and lineage tracing methodologies -- Early development of innate lymphoid cells -- Development of gd T cells, Soldiers on the Front Lines of Immune Battles -- Principles of Advanced Flow Cytometry: A Practical Guide -- Genetic strategies to study T cell development -- A simplified approach to evaluating T cell development by flow cytometry -- Purification of thymocyte and T cell subsets -- Generation of bone marrow chimeras -- Generation of murine T cell effector populations in vitro -- Large-scale isolation of mouse thymic epithelial cells -- Generation of retrogenic mice to investigate T cell developmentPurification of bone marrow precursors to T cells and ILCs -- Studying T cell Development in Neonatal and Adult Thymic Slices -- Induction of Human T Cell Development In Vitro with OP9-DL4-7FS Cells Expressing Human Cytokines -- Methods for Study of Mouse T Cell Receptor a and b Gene Rearrangements -- Ultrasound guided intra-thymic cell injection -- Fetal thymic organ culture and negative selection -- In Vitro Analysis of Thymocyte Signaling -- Identification and purification of human T cell precursors -- In vitro model systems to study human T cell development -- Zebrafish: A Tractable Model for Analysis of T cell Development. .
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  • 35
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    SILAC : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Proteins. ; Cytology—Technique. ; Proteins. ; Cytological Techniques.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed volume explores the most recent methodologies and applications of stable isotope labeling by amino acids in cell culture (SILAC). With the development of new technologies in the field of mass spectrometry and bioinformatics, SILAC-based methods have become the first tool of choice in quantitative proteomics either on its own or in combination with other more recently developed approaches, which is elucidated in the chapters of this book. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, SILAC: Methods and Protocols serves as an ideal guide for researchers working in the area of functional proteomics and other aspects of protein science.
    Materialart: Online-Ressource
    Seiten: XII, 286 p. 41 illus., 31 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071628638
    Serie: Methods in Molecular Biology, 2603
    URL: https://doi.org/10.1007/978-1-0716-2863-8
    DOI: 10.1007/978-1-0716-2863-8
    Sprache: Englisch
    Anmerkung: Dynamic SILAC to Determine Protein Turnover in Neurons and Glia -- SILAC-Based Proteomic Analysis of Meiosis in the Fission Yeast Schizosaccharomyces pombe -- Identification of Protein Interaction Partners in Bacteria Using Affinity Purification and SILAC Quantitative Proteomics -- pSILAC-Based Determination of Cellular Protein Sorting into Extracellular Vesicles -- Quantification of Protein Palmitoylation by Cysteine-SILAC -- Comparative SUMO Proteome Analysis Using Stable Isotopic Labeling by Amino Acids (SILAC) -- A Super-SILAC Approach for Profiling Histone Post-Translational Modifications -- SILAC-Based Quantitative Phosphoproteomics in Yeast -- Phosphotyrosine Profiling Using SILAC -- Chemoproteomic Profiling of Geranyl Pyrophosphate-Binding Proteins -- Quantitative Analysis of the Endoplasmic Reticulum-Associated Proteins Using ER-Localizable Reactive Molecules -- Workflow for Quantitative Proteomic Analysis of Intestinal Organoids Using SILAC -- Stable Isotope Labeling by Amino Acids and Bioorthogonal Noncanonical Amino Acid Tagging in Cultured Primary Neurons -- Heavy Methyl SILAC Metabolic Labeling of Human Cell Lines for High-Confidence Identification of R/K-Methylated Peptides by High-Resolution Mass Spectrometry -- SILAC-Based Quantitative Proteomic Analysis of Drosophila Embryos -- Super-SILAC Quantitative Proteome Profiling of Zebrafish Larvae -- Use of Nuclear and Chromatin Enrichment Procedures for Quantitation of Yeast DNA Replication Proteins Using SILAC -- Combination of Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Substrate Trapping for the Detection of Transient Protein Interactions -- Profiling of Secreted Proteins in Serum-Containing Media Using BONCAT and Pulsed SILAC -- Using SILAC to Develop Quantitative Data Independent Acquisition (DIA) Proteomics Methods -- SILAC-IodoTMT for Assessment of the Cellular Proteome and Its Redox Status -- Targeted Absolute Protein Quantification Using SILAC Internal Standard and Full-Length Protein Calibrators (TAQSI).
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    CCN Proteins : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Proteins. ; Cytology. ; Proteins. ; Cell Biology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This second edition volume expands on the previous edition with updated methodologies and practical tips to overcome obstacles associated with experimentation pertaining to chemistry, biology, physiology, pathology, medical and dental sciences, and pharmacology of CCN proteins. The chapters in this book cover topics such as CCN4 immunofluorescence for tissue microarray; utilizing public molecular biological databases for CCN family research; the effects of CCN4 on pancreatic beta cell proliferation; gene expression analysis of CCNs; novel cell biological assays for measuring bone remodeling activities of CCN proteins; and the function of CCN2 in tubular epithelium cells with a focus on renal fibrogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, CCN Proteins: Methods and Protocols, Second Edition is a valuable resource for experienced CCN researchers looking for new approaches and novice researchers just starting out in the field of CCN research.
    Materialart: Online-Ressource
    Seiten: XIV, 430 p. 86 illus., 66 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9781071627440
    Serie: Methods in Molecular Biology, 2582
    URL: https://doi.org/10.1007/978-1-0716-2744-0
    DOI: 10.1007/978-1-0716-2744-0
    Sprache: Englisch
    Anmerkung: CCN Proteins - Cellular Communication Network Factors: Expanding their Repertoire toward a New Concept -- Optimal CCN4 Immunofluorescence for Tissue Microarray -- Cellular Fluorescence Imaging for the Evaluation of Bioactivity of CCN Family Proteins- Imaging of Molecular Interaction between CCN Protein and Its Binding Partners: An In Situ Proximity Ligation Assay of Interaction Between CCN2 and Rab14 in Chondrocytes -- Western Blot Protocols for Analysis of CCN Proteins and Fragments in Exosomes, Vesicle-free Fractions, and Cells -- Comprehensive Method for Exosome Isolation and Proteome Analysis for Detection of CCN Factors in/on Exosomes -- Evaluation of the Molecular Interaction between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance -- Protocols for Screening Peptides Binding to CCN Family Proteins and their Extended Utility -- Transfection, Spinfection, Exofection, and Luciferase Assays for Analysis of CCN Genes Expression Mechanism -- Analyses of the Post-Transcriptional Regulation of CCN Genes: Approach to Multiple Steps of CCN2 Gene Expression -- Protocol for CRISPR/Cas Genome Editing for Investigating Cell Communication Network -- Utilizing Public Molecular Biological Databases for CCN Family Research -- Evaluation of the Effects of CCN4 on Pancreatic Beta Cell Proliferation -- Analysis of CCN Functions in Liver Regeneration After Partial Hepatectomy -- The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues -- Analysis of Chemotactic Property of CCN2/CTGF in Intramembranous Osteogenesis -- Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins -- Imaging Analysis of Neurotrophic Effects by CCN2 Protein in Neuronal Precursor Cells Derived from Human Induced Pluripotent Stem Cells -- Gene Expression Analysis of CCNs Along with Odontoblastic Differentiation In Vivo -- Angiogenesis Assays for the Analysis of CCN Proteins -- Using the Bleomycin-Induced Model of Fibrosis to Study the Contribution of CCN Proteins to Scleroderma Fibrosis -- Atomic Force Microscopy-Based Measurements of Retinal Microvessel Stiffness in Mice with Endothelial-Specific Deletion of CCN1 -- Immunohistochemical Analysis of CCN2 in Experimental Fracture Healing Models -- Mouse Models of Tumor Bone Metastasis and Invasion for Studying CCN Proteins -- Regulation of CCN2 and Its Bioactivity by Advanced Glycation End Products -- Analysis of CCN4/WISP1 Effects on Joint Tissues Using Gain and Loss of Function Approaches -- Generation of Conditional KO Mice of CCN2 and Its Function in the Kidney -- Analysis of the Function of CCN2 in Tubular Epithelium Cells with a Focus on Renal Fibrogenesis.
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    Online-Ressource
    Difference Gel Electrophoresis : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Proteins. ; Proteins.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: The second edition of this volume provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Difference Gel Electrophoresis: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field. .
    Materialart: Online-Ressource
    Seiten: XII, 485 p. 82 illus., 74 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9781071628317
    Serie: Methods in Molecular Biology, 2596
    URL: https://doi.org/10.1007/978-1-0716-2831-7
    DOI: 10.1007/978-1-0716-2831-7
    Sprache: Englisch
    Anmerkung: Two-Dimensional Gel Electrophoresis and 2D-DIGE -- Top-down Proteomics and Comparative 2D-DIGE Analysis -- DIGE Analysis Software and Protein Identification Approaches -- Native DIGE for Quantitative and Functional Analysis of Protein Interactomes -- Comparative Two-dimensional Fluorescence Gel Electrophoresis -- Identification of Ubiquitination associated Proteins using 2D-DIGE -- DIGE-based Phosphoproteomic Analysis -- DIGE-based Biomarker Discovery in Blood Cancers -- DIGE Saturation Labeling for Scarce Amounts of Protein from Formalin-fixed Paraffin-embedded (FFPE) Tissue -- DIGE Analysis of ProteoMiner™ Fractionated Serum/Plasma Samples -- Comparative 3-sample 2D-DIGE Analysis of Skeletal Muscles -- Proteomic identification of saliva proteins as non-invasive diagnostic biomarkers -- Analysis of the saliva proteome using 2D-DIGE -- DIGE Analysis of Clinical Specimens -- DIGE Analysis of Animal Tissues -- Rapid 2D-DIGE Proteomic Analysis of Mouse Liver within One Week -- 2D-DIGE analysis of liver disease in mice -- 2-Dye Versus 3-Dye DIGE for Comparative Testis Tissue Proteomic Analysis -- 2-CyDye based 2D-DIGE Analysis of Aged Human Muscle Biopsy Specimens -- Identification of Subproteomic Markers for Skeletal Muscle Profiling -- DIGE Analysis of Fish Tissues -- Sample preparation and protein determination for 2D-DIGE proteomics -- Protein Digestion for 2D-DIGE Analysis -- Subcellular Fractionation for DIGE-based Proteomics -- DIGE Analysis of Immunodepleted Plasma -- Bioinformatic Analysis of the Subproteomic Profile of Cardiomyopathic Tissue -- Elucidating Cellular Metabolism and Protein Difference Data from DIGE Proteomics Experiments using Enzyme Assays -- Enzyme Assay Methods to Validate DIGE Proteomics Data -- Immunoblot Analysis of DIGE-based Proteomics -- Verification of Protein Changes determined by 2D-DIGE based Proteomics using Immunofluorescence Microscopy -- Histological and Histochemical Microscopy used to verify 2D-DIGE Pathoproteomics. .
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  • 38
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    Alzheimer’s Disease : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Neurosciences. ; Nervous system—Diseases. ; Neurophysiology. ; Neurons. ; Neuroscience. ; Neurological Disorders. ; Cellular Neuroscience.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative disorders. Contributed to by world-renowned experts, the chapters in this book are divided into five parts. Part One discusses human post-mortem brain preparations including single-cell isolation and use of specialized imaging. Part Two talks about neural cellular models using primary and human induced pluripotent stem cells to model aspects of the human brain. Part Three details nucleic acid analyses including transcriptomic and somatic genomic changes, and Part Four discusses lipid analyses via mass spectrometry. Lastly, Part Five covers protein analyses, particularly Aβ and Tau. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Alzheimer’s Disease: Methods and Protocols is a valuable tool for all researchers who want to expand their knowledge and understanding of this disease and other related dementias.
    Materialart: Online-Ressource
    Seiten: XIII, 340 p. 61 illus., 59 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071626559
    Serie: Methods in Molecular Biology, 2561
    URL: https://doi.org/10.1007/978-1-0716-2655-9
    DOI: 10.1007/978-1-0716-2655-9
    Sprache: Englisch
    Anmerkung: Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue -- Extraction and Purification of Single Nuclei from Frozen Human Brain Tissue -- Isolation of Human Microglia from Neuropathologically Diagnosed Cases in the Single-Cell Era -- Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images -- Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer’s Disease -- Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer’s Disease -- Modeling Alzheimer’s Disease using Human Brain Organoids -- 3D Biohybrid StarPEG-Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer’s Disease Pathology -- Computational Approaches to Assess Abnormal Metabolism in Alzheimer’s Disease Using Transcriptomics -- FISHing for Chromosome Instability and Aneuploidy in the Alzheimer’s Disease Brain -- Somatic CNV Detection by Single-Cell Whole-Genome Sequencing in Post-Mortem Human Brain -- Mass Spectrometry Analysis of the Human Brain Sphingolipidome -- Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer’s Research -- The Use of Affinity Purification-Mass Spectrometry to identify Phosphorylates Tau Interactors in Alzheimer’s Disease -- In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains -- Aβ and Tau Prions Causing Alzheimer’s Disease.
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  • 39
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    Chemokine-Glycosaminoglycan Interactions : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Immunology. ; Cytology. ; Immunology. ; Cell Biology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed volume provides methods to guide assay development, procedures designed to investigate the chemokine and glycosaminoglycan (GAG) networks, as well as their interactions, in a wide range of organs and tissues in disease and in health. The initial chapters in this book present in vivo models used to examine the roles of chemokines and GAGs in normal physiology and in the pathophysiology of disease. The book then explores present cell- and tissue-based in vitro assays to examine chemokine:GAG interactions. Finally, analytic approaches are presented that provide assays for measuring GAGs, chemokines, and cellular responses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chemokine-Glycosaminoglycan Interactions: Methods and Protocols serves as an ideal guide for researchers seeking to analyze chemokine and GAG functions, interactions, and molecular mechanisms in vivo and in vitro.
    Materialart: Online-Ressource
    Seiten: XV, 262 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071628355
    Serie: Methods in Molecular Biology, 2597
    URL: https://doi.org/10.1007/978-1-0716-2835-5
    DOI: 10.1007/978-1-0716-2835-5
    Sprache: Englisch
    Anmerkung: A Surgical Approach to Hindlimb Suspension: A Mouse Model of Disuse-Induced Atrophy -- Remote Ischemic Pre-Conditioning (RIPC) -- Mouse Corneal Transplantation -- Analysis of Chemokine-to-GAG Interactions in Model of Donor Renal Allograft Transplant -- Mouse Models of Renal Allograft Transplant Rejection: Methods to Investigate Chemokine:GAG Interaction and Therapeutic Blockade -- Ex Vivo Perfusion System to Analyze Chemokine-Driven Leukocyte Adhesion -- In Vitro (Trans)migration Experiment Using Chemokines as Stimulatory Factor -- The Use of Campenot Trichambers for the Study of Peripheral Neuronal Growth and Survival in Presence of Thrombotic Factors and Serpins -- Flow Cytometry Analysis of Immune Cell Responses -- Detection of Chemokine Binding Proteins Association to Cell Surface Glycosaminoglycans by Flow Cell Cytometry and Indirect Immunofluorescence -- Protein Microarrays and Their Fabrication -- NMR Methods for Characterization of Glycosaminoglycan-Chemokine Interactions -- Glycosaminoglycan Analysis: Purification, Structural Profiling, and GAG-Protein Interactions -- Isolation and Compositional Analysis of Glycosaminoglycans -- How to Design Peptides -- Methods to Assess Chemokine Binding and Anti-Chemotactic Activity of Virus Proteins -- Producing Biologics with Defined N-Glycosylation in Plants -- Native Deglycosylation and Size Exclusion Chromatography of Viral Chemokine Binding Proteins for Structural Discovery.
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  • 40
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    Online-Ressource
    Muscular Dystrophy Therapeutics : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Medical genetics. ; Musculoskeletal system. ; Therapeutics. ; Medical Genetics. ; Musculoskeletal system. ; Therapeutics.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed book presents a comprehensive collection of state-of-the-art protocols on muscular dystrophy therapeutics, covering therapeutics using antisense oligonucleotides, gene replacement, genome editing, small molecules, stem cells, and antibodies. Written by leaders in the field, the volume explores techniques that are currently in use and are starting an exciting therapeutic revolution in muscular dystrophy. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Muscular Dystrophy Therapeutics: Methods and Protocols serves as an ideal resource to inspire readers and provide tips, strategies, and advice to develop new therapeutic technologies for this group of diseases.
    Materialart: Online-Ressource
    Seiten: XV, 575 p. 98 illus., 50 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071627723
    Serie: Methods in Molecular Biology, 2587
    URL: https://doi.org/10.1007/978-1-0716-2772-3
    DOI: 10.1007/978-1-0716-2772-3
    Sprache: Englisch
    Anmerkung: Current Strategies of Muscular Dystrophy Therapeutics: An Overview -- The Story of Viltolarsen: From Preclinical Studies to FDA Approval -- Rapid Freezing of Skeletal and Cardiac Muscles Using Isopentane Cooled with Liquid Nitrogen and Tragacanth Gum for Histological, Genetic, and Protein Expression Studies -- Cardiac and Skeletal Muscle Pathology in the D2/mdx Mouse Model and Caveats Associated with the Quantification of Utrophin -- Physiological Assessment of Muscle, Heart, and Whole Body Function in the Canine Model of Duchenne Muscular Dystrophy -- Restoring Dystrophin Expression by Skipping Exon 6 and 8 in Neonatal Dystrophic Dogs -- Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes -- Restoring Dystrophin Expression with Duchenne Muscular Dystrophy Exon 45 Skipping in Induced-Pluripotent Stem Cell-Derived Cardiomyocytes -- Quantitative Evaluation of Exon Skipping in Urine-Derived Cells for Duchenne Muscular Dystrophy -- Use of Glycine to Augment Exon Skipping and Cell Therapies for Duchenne Muscular Dystrophy -- Morpholino-Mediated Exons 28–29 Skipping in Dysferlin -- Knocking Down DUX4 in Immortalized Facioscapulohumeral Muscular Dystrophy Patient-Derived Muscle Cells -- Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy -- Developing Therapeutic Splice-Correcting Antisense Oligomers for Adult-Onset Pompe Disease with c.-32-13T〉G Mutation -- Molecular and Biochemical Assessment of Gene Therapy in the Canine Model of Duchenne Muscular Dystrophy -- Histological Assessment of Gene Therapy in the Canine DMD Model -- MRI Evaluation of Gene Therapy in the Canine Model of Duchenne Muscular Dystrophy -- Assessment of the Gene Therapy Immune Response in the Canine Muscular Dystrophy Model -- Use of Mesenchymal Stem Cells to Enhance the Efficacy of Gene Therapy -- Exon-Skipping for a Pathogenic COL6A1 Variant in Ullrich CMD -- CRISPR-Cas9 Correction of Duchenne Muscular Dystrophy in Mice by a Self-Complementary AAV Delivery System -- Preparation of NanoMEDIC Extracellular Vesicles to Deliver CRISPR-Cas9 Ribonucleoproteins for Genomic Exon Skipping -- Restoration of Dystrophin Expression in Mdx-Derived Muscle Progenitor Cells Using CRISPR/Cas9 System and Homology-Directed Repair Technology -- Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy -- High-Throughput Screening to Identify Modulators of Sarcospan -- Identifying FDA-Approved Drugs that Upregulate Utrophin A as a Therapeutic Strategy for Duchenne Muscular Dystrophy -- Monitoring Membrane Injury-Triggered Endocytosis at Single Cell and Single Vesicle Resolution -- Evaluation of hiPSC-Derived Muscle Progenitor Cell Transplantation in a Mouse Duchenne Muscular Dystrophy Model -- Quantification of Muscle Satellite Stem Cell Divisions by High Content Analysis -- Systemic Delivery of a Monoclonal Antibody to Immunologically Block Myostatin in the A17 Mouse Model of OPMD.
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    Online-Ressource
    Signal Transduction Immunohistochemistry : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Biology—Technique. ; Experimental immunology. ; Tissues. ; Chemistry. ; Immunological Techniques. ; Tissues.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This new edition collects diverse protocols compiled by experts from different areas of research as well as by biotech researchers developing novel technologies in the area of immunohistochemistry (IHC). After a few chapters to help orient novices entering the biomedical arena, the book includes methods chapters covering multiplex IHC including fluorescence and chromogenic techniques, combination of IHC with In Situ Hybridization (ISH), wavelet transform approach for organelle tracking, transcription factors in human stem cells, differentiation of mesenchymal stem cells, 3D imaging, phenotyping of glial cells in the human brain, tissue fixation, permeabilization, and cryo-preservation, as well as other topics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Signal Transduction Immunohistochemistry: Methods and Protocols, Third Edition aims to arm novices and experts with vital protocols they can use either as-is or tailor them for specific experimental needs.
    Materialart: Online-Ressource
    Seiten: XI, 328 p. 84 illus., 67 illus. in color. , online resource.
    Ausgabe: 3rd ed. 2023.
    ISBN: 9781071628119
    Serie: Methods in Molecular Biology, 2593
    URL: https://doi.org/10.1007/978-1-0716-2811-9
    DOI: 10.1007/978-1-0716-2811-9
    Sprache: Englisch
    Anmerkung: Top 5 Considerations When Choosing an Antibody -- Validating Antibody Specificities for Immunohistochemistry by Protein Blotting -- Recent Advances in Chromogens for Immunohistochemistry -- Overview of Imaging Techniques in Immunohistochemistry -- Visualizing Activated Myofibroblasts Resulting from Differentiation of Mesenchymal Stem Cells -- Clinical Applications of Flow Cytometry in Cancer Immunotherapies: From Diagnosis to Treatments -- Labeling of Phospho-Specific Antibodies with oYo-Link® Epitope Tags for Multiplex Immunostaining -- Multiplex Immunochromogenic Tissue Staining Employing Primary Antibodies from the Same Species -- 3D Imaging for Cleared Tissues and Thicker Samples on Confocal and Light-Sheet Microscopes -- Optical Tissue Clearing Enables Three-Dimensional Morphometry in Experimental Nerve Regeneration Research -- Protocol and Software for Automated Detection of Lysosome Active “Runs” and “Flights” with Wavelet Transform Approach -- Phenotyping of M1 and M2a Macrophages and Differential Expression of ACE-2 on Monocytes by Flow Cytometry: Impact of Cell Culture Conditions and Sample Processing -- In Situ Hybridization (ISH) Combined with Immunocytochemistry (ICC) Co-Detection of Phosphorylated EGFR in A431 Cultured Cells -- In Situ Hybridization (ISH) Combined with Immunohistochemistry (IHC) for Co-Detection of EGFR RNA and Phosphorylated EGFR Protein in Lung Cancer Tissue -- Multiplex Spatial Protein Detection by Combining Immunofluorescence with Immunohistochemistry -- Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells -- Immunohistochemical Techniques for Phosphoproteins -- Visualizing Cofilin-Actin Filaments by Immunofluorescence and CryoEM: Essential Steps for Observing Cofilactin in Cells -- Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Human Formalin-Fixed Paraffin-Embedded Brain Sections -- Spatially Characterizing the Immune Contexture in Mouse Tissue Using Multiplex Immunohistochemistry -- Highly Multiplexed Immuno-Fluorescence Imaging for Quantitative Spatial Analysis in Tissue Samples with ChipCytometryTM.
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    Online-Ressource
    Golgi : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Cytology. ; Cell Biology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This volume provides readers with a collection of new and classical methods, techniques, and applications used to address enduring questions about the structure and functions of the Golgi complex. The chapters in this volume cover diverse topics ranging from model systems; live and fixed cell imaging techniques; in vitro biochemical reconstitution systems; and specific methods developed to study Golgi formation, maintenance, and functions under physiological and pathological conditions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Golgi: Methods and Protocols is a valuable tool for researchers in the field who wish to explore new areas of Golgi biology and for new investigators interested in exploring Golgi structure and function.
    Materialart: Online-Ressource
    Seiten: XVII, 816 p. 196 illus., 167 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071626399
    Serie: Methods in Molecular Biology, 2557
    URL: https://doi.org/10.1007/978-1-0716-2639-9
    DOI: 10.1007/978-1-0716-2639-9
    Sprache: Englisch
    Anmerkung: Live Cell Imaging of Yeast Golgi Dynamics -- Quantification of Golgi Protein Mislocalization to the Budding Yeast Vacuole -- Immunofluorescence as a Method to Study Golgi Organization in Larval Salivary Glands of Drosophila melanogaster -- Microscopy and Immunocytochemistry-Based Methods to Study Cell Wall Biosynthetic Enzymes in the Golgi -- Reconstitution of Golgi Biogenesis in Permeabilized Trypanosoma brucei Cells -- Generation of GM130 Conditional Knockout Mouse -- Monitoring Effects of Membrane Traffic via Changes in Cell Polarity and Morphogenesis in Three-Dimensional Human Pluripotent Stem Cell Cysts -- Immunofluorescence Microscopy of the Mammalian Golgi Apparatus -- Studying the Organization of the Golgi by Super-Resolution Microscopy -- Super-Resolution Live Imaging of Cargo Traffic Through the Golgi Apparatus in Mammalian Cells -- Studying Golgi Structure and Function by Thin Section TEM -- Algorithm for Modern Electron Microscopic Examination of the Golgi Complex -- High-Pressure Freezing Followed by Freeze-Substitution, An Optimal Electron Microscope Technique to Study Golgi Apparatus Organization and Membrane Trafficking -- Negative Staining Electron Microscopy for Morpho-Functional Characterization of Purified Golgi Membranes from Mammalian Cells -- An Electron Tomographic Analysis of Giantin Deficient Golgi Proposes a New Function of the Golgin Protein Family -- Modeling the Cryo-EM Structure of the Exocyst Complex -- Quantitatively Assessing Co-Localization of Golgi Proteins by Distance Analysis Using the DiAna Software -- A Primer on Deep Learning-Based Cellular Image Classification of Changes in the Spatial Distribution of the Golgi Apparatus After Experimental Manipulation -- Reconstituting Vesicle Budding from the TGN and Immunoisolation of Vesicles Enriched with a Specific Cargo Client -- Common Assays in Mammalian Golgi Studies -- In Vitro Methods to Investigate the Disassembly of the Golgi Ribbon during the G2-M Transition of the Cell Cycle -- Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines -- Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System -- Generation of Stable Cell Lines Expressing Golgi Reassembly Stacking Proteins (GRASPs) by Viral Transduction -- Quantitative Proteomics Analysis of Purified Rat Liver Golgi -- Comparative Genomics for Evolutionary Cell Biology using AMOEBAE: Understanding the Golgi and Beyond -- Common Markers and Small Molecule Inhibitors in Golgi Studies -- Visualizing Reversible Cisternal Stacking in Budding Yeast Pichia pastoris -- Methods for Studying Membrane-Proximal GAP Activity on Prenylated Rab GTPase Substrates -- Studying the Role of Lipid Geometry in COPI Vesicle Formation -- Unbiased Quantification of Golgi Scattering and Golgi-Centrosome Association -- Detection and Analysis of Microtubule Nucleator γ-Tubulin Ring Complex -- Quantification of Golgi Entry and Exit Kinetics of Protein Cargoes -- CARTS Formation Assay -- Quantification of Protein Exit at the Trans-Golgi Network -- Endosomal Transport to Lysosomes and the Trans-Golgi Network in Neurons and Other Cells: Visualizing Maturational Flux -- Immunoprecipitation and Western Blot Analysis of AP-1 Clathrin-Coated Vesicles -- Live imaging of Golgi Outposts in Drosophila Dendritic Arbors -- Targeted Protein Unfolding at the Golgi Apparatus -- Modeling N-Glycosylation: A Systems Biology Approach for Evaluating Changes in the Steady State Organization of Golgi Resident Proteins -- Simple N-Glycan Profile Analysis Using Lectin Staining, Mass Spectrometry, and GlycoMaple -- In Vitro Methods to Study the Golgi Apparatus Role in Proteoglycan and Glycosaminoglycan Synthesis -- Analysis of Golgi Protein Acetylation using In Vitro Assays and Parallel Reaction Monitoring Mass Spectrometry -- Identification and Characterization of GRASP55 O-GlcNAcylation -- Assaying Sterol-Regulated ER-to-Golgi Transport of SREBP Cleavage-Activating Protein Using Immunofluorescence Microscopy -- Analysis of Golgi Morphology Using Immunofluorescence and CellProfiler Software -- Analysis of Golgi Secretory Functions in Cancer.
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    Mechanobiology : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Biophysics. ; Cell interaction. ; Biomolecules. ; Cytology. ; Mechanobiological Cell Signaling. ; Molecular Biophysics. ; Cell Biology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed book collects methodologies exploring mechanobiology, the involvement of mechanical forces in cell fate specification and in controlling single and collective cell behaviors such as directed migration, morphogenesis, wound healing, and the immune response. The volume features methods to quantify the mechanical properties of cells and adhesion proteins, to expose cells to external mechanical forces, to quantitatively characterize mechano-responses at various scales, to measure forces applied by cells on the extracellular matrix, as well as chapters on force measurement inside cells, probing cell signaling and gene expression in response to force, and biophysical modeling of cell shape and protein dynamics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary material and reagents, step-by-step and readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mechanobiology: Methods and Protocols aims to provide meaningful tools for cell and developmental biologists approaching the study of cell and tissue dynamics from a mechanobiological perspective, molecular biologists interested in the effects of force on proteins, as well as for cancer biologists and biophysicists.
    Materialart: Online-Ressource
    Seiten: XII, 343 p. 104 illus., 96 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071628515
    Serie: Methods in Molecular Biology, 2600
    URL: https://doi.org/10.1007/978-1-0716-2851-5
    DOI: 10.1007/978-1-0716-2851-5
    Sprache: Englisch
    Anmerkung: Measuring Cell Mechanical Properties Using Microindentation -- In Situ Measurements of Cell Mechanical Properties Using Force-Spectroscopy -- Quantification of Apparent Membrane Tension and Membrane-to-Cortex Attachment in Animal Cells Using Atomic Force Microscopy-Based Force Spectroscopy -- Characterizing the Biophysical Properties of Adhesive Proteins in Live Cells Using Single Molecule Atomic Force Microscopy -- Application of Shear Stress to Endothelial Cells Using a Parallel Plate Flow Chamber -- Cell Stretcher Assay to Analyze Mechanoresponses to Cyclic Stretching -- Two-Point Optical Manipulation of Cell Junctions in the Early Epithelium of the Drosophila Embryo -- A Microfluidic-Like System (MLS) to Grow, Image, and Quantitatively Characterize Rigidity-Sensing by Plant’s Roots and Root Hair Cells -- Photoresponsive Hydrogels for Studying Mechanotransduction of Cells -- Analyzing Mechanically Evoked Currents at Cell-Substrate Junctions -- Quantifying Strain Sensing Protein Recruitment During Stress Fiber Repair -- Quantification of Invadopodia Formation and Matrix Degradation Activity -- Measuring Cellular Traction Forces with Micropillar Arrays -- Imaging Cell Adhesive Force at the Single Molecule Level -- Multiplexed Molecular Tension Sensor Measurements Using PIE-FLIM -- Visualizing Neurons under Tension In Vivo with Optogenetic Molecular Force Sensors -- Single-Cell Quantification of the Mechanical Stability of Cell-Cell Adherens Junction Using Glass Micropipettes -- Using Micropatterned Supported Lipid Bilayers to Probe the Mechanosensitivity of Signaling Receptors -- Monitoring Mechano-Regulation of Gene Expression by RNA Sequencing -- Testing the Role of Focal Adhesion Kinase (FAK) in Topography-Mediated Stem Cell Differentiation by Inhibiting FAK Phosphorylation -- Long-Term Fluorescence Recovery After Photobleaching (FRAP) -- Simulating 3D Cell Shape with the Cellular Potts Model.
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    Glycolipids : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Membranes (Biology). ; Lipids. ; Biological Membranes. ; Lipidology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This detailed volume presents a variety of specialized analytical methods on a wide range of glycolipids. From sphingoglycolipids to lipid A, an immune system stimulant present in lipopolysaccharide, the book delves into how glycolipid structure on the surface of the cell membrane, which characterizes each organism, is crucial for the coexistence or repulsion between organisms. In addition, glycolipids play an important role in infections in animals and other organisms by targeting host cell membranes, if enveloped viruses are considered as living organisms. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Glycolipids: Methods and Protocols serves as an ideal guide to the most advanced glycolipid research in an effort to help researchers make their research more fruitful.
    Materialart: Online-Ressource
    Seiten: XII, 302 p. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9781071629109
    Serie: Methods in Molecular Biology, 2613
    URL: https://doi.org/10.1007/978-1-0716-2910-9
    DOI: 10.1007/978-1-0716-2910-9
    Sprache: Englisch
    Anmerkung: Immunomodulatory Functions of α-GalCer and a Derivative, α-Carba-GalCer -- Chemical Synthesis and Molecular Interaction Analysis of a-Galactosyl Ceramide Derivatives as CD1d Ligands -- Immunomodulatory Functions of Glycolipids from Pathogens -- Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As -- Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines -- Chemical Synthesis of Phosphatidylglucoside -- Sialidase-Resistant Ganglioside GM3 Analogues: Evaluation of Biological Activity -- Chemical Synthesis of Gangliosides -- Sialyltransferase Activity Assay for Ganglioside GM3 Synthase -- Construction of Sphingolipid Remodeled Cells by Genome Editing -- Mass Spectrometry of Neutral Glycosphingolipids -- Structural Analyses of the Glycolipids in Lipid Rafts -- Extraction, Purification, and Chemical Degradation of LPS from Gut Microbiota Strains -- NMR Analysis of Mammalian Glycolipids -- Distribution of Glycolipids in the Plasma Membrane Monitored by Specific Probes in Combination with Sodium Dodecyl Sulfate-Digested Freeze-Fracture Replica Labeling (SDS-FRL) -- Biochemical and Microscopic Analyses for Sphingolipids and Its Related Molecules in Phagosomes -- Single-Molecule Imaging of Ganglioside Probes in Living Cell Plasma Membranes -- Assays and Utilization of Enzymes Involved in Glycolipid Metabolism in Bacteria and Fungi -- Molecular Dynamics of Glycolipids in Liposomes -- Inhibitors of Glucosylceramide Synthase -- Comprehensive Glycan Analysis of Sphingolipids in Human Serum/Plasma.
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    Online-Ressource
    Biomining Technologies : Extracting and Recovering Metals from Ores and Wastes (2023)
    Cham : Springer International Publishing
    Details
    Schlagwörter: Industrial microbiology. ; Biotechnology. ; Microbial populations. ; Refuse and refuse disposal. ; Industrial Microbiology. ; Biotechnology. ; Microbial Communities. ; Waste Management/Waste Technology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This book describes emerging and established industrial processes of biomining technologies used for the recovery of metals of economic interest from, e.g. mineral ores, mining and electronic wastes using microbiological technologies. Multiple chapters focus on engineering design and operation of biomining systems. Several industrial case studies from China, Chile, Peru, Russia/Kazakhstan and Finland are included, which emphasises the practical approach of the book. The reader not only learns more about the biology, diversity and ecology of microorganisms involved in biomining processes, but also about microbial biomolecular and cultivation tools used in the biomining industry. Special emphasis is put on emerging biotechnologies enabling the use of biomining for recycling metals from e-wastes, waste streams and process waters. Finally, the future impacts and direction of biomining towards sustainability in a metal-demanding world are also highlighted. The book is aimed at an interdisciplinary audience involving operators and researchers working across disciplines including geology, chemical engineering, microbiology and molecular biology. This is reflected by the content of this book, as well as by its authors, who are all leading practitioners and authorities in their fields.
    Materialart: Online-Ressource
    Seiten: XII, 314 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031053825
    URL: https://doi.org/10.1007/978-3-031-05382-5
    DOI: 10.1007/978-3-031-05382-5
    Sprache: Englisch
    Anmerkung: Chapter 1: Evolution and current status of mineral bioprocessing technologies -- Chapter 2: Design, Construction and Modelling of Bioheaps -- Chapter 3: Engineering Designs and Challenges of Stirred Tank Systems -- Chapter 4: Bioprocessing of Refractory Gold Ores: The BIOX, MesoTHERM and ASTER Processes -- Chapter 5: Biomining Microorganisms: Diversity and Modus Operandi -- Chapter 6: Biomolecular and Cultivation Tools -- Chapter 7: Microbial ecology of bioheaps, stirred tanks and mine wastes -- Chapter 8: Biomining in China: history and current status -- Chapter 9: Copper Bioleaching Operations in Chile: Towards New Challenges and Developments -- Chapter 10: Heap bioleaching of an enargite-dominant ore body: Minera Yanacocha, Péru -- Chapter 11: Bio-oxidation of gold ores in Russia and Kazakhstan -- Chapter 12: Biomining in Finland: Commercial Application of Heap and Tank Bioleaching Technologies for Nickel Recovery -- Chapter 13: Mineral Bioleaching in Brackish and Saline Environments -- Chapter 14: Metal Recovery from E-wastes -- Chapter 15:Reductive Mineral Bioprocessing -- Chapter 16: Biological Removal and Recovery of Metals from Waste Streams and Process Waters -- Chapter 17: The Future of Biomining: Towards Sustainability in a Metal-demanding World.
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  • 46
    Online-Ressource
    Online-Ressource
    Sustainable Agriculture Reviews 58 : Phosphorus Use Efficiency for Sustainable Agriculture (2023)
    Cham : Springer International Publishing
    Details
    Schlagwörter: Agriculture. ; Earth sciences. ; Geography. ; Pollution. ; Biotechnology. ; Agriculture. ; Earth and Environmental Sciences. ; Pollution. ; Biotechnology.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: This book presents recently-developed crop, soil, and management practices that can be used to improve phosphorous use efficiency in agriculture. Food security highly depends on the availability of plant nutrients such as phosphorus, yet rock phosphate reserves are expected to be exhausted in the next 50–100 years. Moreover, about 80% of the phosphorous fertilizers applied to soils become unavailable to plants due to phosphorous fixation in iron and aluminum oxides in acidic soils and with carbonates in alkaline soils. As a consequence, only 10-15% of applied phosphorous is up taken by crops. Therefore, there is a need for advanced practices for improving phosphorus use efficiency.
    Materialart: Online-Ressource
    Seiten: XIX, 235 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031161551
    Serie: Sustainable Agriculture Reviews, 58
    URL: https://doi.org/10.1007/978-3-031-16155-1
    DOI: 10.1007/978-3-031-16155-1
    Sprache: Englisch
    Anmerkung: 1. Permaculture principles, practices, and environmentalism (Jungho Suh) -- 2. Sources and solubilization of phosphatic fertilizers (Waleed Fouad Abobatta, Amr Mahmoud Abdel Gawad, Haythum M. Salem, Mohamed A. Abdel-Salam, Taghred A. Hashim) -- 3. Organic phosphorous as an alternative to mineral phosphatic fertilizers (Muhammad Zaina, Muhammad Adeelb, Noman Shakoor, Muhammad Arslan Ahmad, Saliha Maqboole, Jiusheng Li, Shafeeq Ur-Rahman, Xu Ming, Asif Iqbal, Waqar Afzal Malik, Aiwang Duan) -- 4. Adaptive responses of crop species against phosphorus deficiency (Mehtab Muhammad Aslam, Aisha Lawan Idris, Eyalira Jacob Okal, Muhammad Waseem) -- 5. Biochar for sustainable phosphorus management in agroecosystems (Komel Jehangir, Muhammad Riaz, Rashid Mahmood, Muhammad Arif) -- 6. Phenotyping for assessing genotypic variation in phosphorus use efficiency (Amjad Farooq, Waqas Shafqat Chattha, Muhammad Tehseen Azhar, Azeem Iqbal Khan, Amir Shakeel) -- 7. Advanced biotechnological tools for improving phosphorus 1 use efficiency (Hafiza Aasia Malik, Atta Ur Rahman, Fazal Akbar, Nisar Ahmad, Syed Shujait Ali, Muhammad Suleman, Shahid Ali, Zahid Hussain, Nasib Zaman, Akhtar Rasool, Muzafar Shah, Muhammad Israr, Asif Iqbal) -- 8. Role of arbuscular mycorrhizal fungi in plant phosphorus acquisition for sustainable agriculture (Muhammad Riaz, Muhammad Tehseen Azhar, Muhammad Kamran, Omar Aziz, Xiurong Wang) -- 9. Phosphorus cycle enzymes to remedy soil phosphorus deficiency (Alhassan Idris Gabasawa) -- 10. Phosphorus nutrition enhancement of biological nitrogen 1 fixation in pastures (Suleiman Kehinde Bello1, Taofeek Olatunbosun Muraina, Saheed Olaide Jimoh, Ibraheem Olamide Olasupo, Samaila Usman) -- Index.
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  • 47
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    Online-Ressource
    Food Security and Safety Volume 2 : African Perspectives (2023)
    Cham : Springer International Publishing
    Details
    Schlagwörter: Food security. ; Food—Safety measures. ; Agriculture. ; Food Security. ; Food Safety. ; Agriculture.
    In: Springer Nature eBook
    Beschreibung / Inhaltsverzeichnis: Sustainable food production is a global challenge with respect to climate change and an ever-increasing world population. Conventional crop production using agrochemicals presents human health and environmental challenges. Rising concerns about environmental sustainability have increased attention toward improved, efficient, and sustainable means of crop production. Various strategies are employed in enhancing crop production to adapt and mitigate climate change and ensure food security. The future of food production relies on improving productivity without compromising long-term productivity and environmental sustainability. Feeding the ever-increasing world population would require concerted efforts by all stakeholders to combat the impact of climate change and numerous ecological challenges facing food production. Hence, innovative technologies and methods are indispensable in mitigating the effects on food security. The book looks at the current challenges and solutions, from an African perspective, regarding food safety and health management, food security and nutrition, climate change and sustainable food production, and forest resources and food security. The target audience is scientists, graduate students, researchers, academicians, and professionals in food production for sustainable development and ecosystem management. This book will also be helpful to policymakers and specialists in framing future feasible agro-ecosystem policies.
    Materialart: Online-Ressource
    Seiten: XXXVI, 483 p. 74 illus., 66 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031096143
    URL: https://doi.org/10.1007/978-3-031-09614-3
    DOI: 10.1007/978-3-031-09614-3
    Sprache: Englisch
    Anmerkung: 1-The potential of resistant starch type 1 for nutritional food security -- 2-Evaluation of bioaccumulation of heavy metals in some fish species from the rice farms’ channels of Pouss (Far-North, Cameroon) -- 3-Evaluation of the levels of nine heavy metals in five crops using AAS and XRF -- 4-The role of food in the health management of geriatrics -- 5-Genetically modified crops: perspectives and safety concerns in Africa -- 6-Indigenous leafy vegetables and health management in South Western Nigeria: A review based on Osun State -- 7-Combined application of subsurface drainage and fertilization, a method to reduce the effects of iron and sulfide toxicities in irrigated rice fields in Burkina Faso -- 8-Is food medicine? Lessons from a household survey on plants used to manage anaemia in Kilifi County, Kenya -- 9-Plantain bioactives: An underutilised food resource in Africa -- 10-New perspectives in the utilization of African leafy vegetables -- 11-The uptake of farming technological innovations for food security in Kejom Ketinguh of the North West region of Cameroon. A contribution to anthropology of food production -- 12-Food and nutrition insecurity in Africa: The primary drivers and sustainable strategies to improve the current status -- 13-Marker-assisted selection (MAS): Untapped potential for enhancing food and nutrition securities in Sub Saharan Africa -- 14-Harnessing the opportunities for sustainable small-scale rural farming towards attaining food security in Southern Africa -- 15-Improving food security in Africa through sustainable utilization of selected climate smart emerging crops: A case of Botswana and Namibia -- 16-Essentials of nutraceuticals and probiotics -- 17-Phenotypic characterisation of nine accessions of okra -- 18-Long-term restorative farming effects on soil biological properties for carbon stock, soil quality and yield in a Nigerian northern guinea savanna alfisols -- 19-Climate change: impact on food security for health management and its adaptation strategies for sustainability among households in Southeast, Nigeria -- 20-Climate change, growth in agriculture value added, food availability and economic growth nexus in the Gambia: A Granger causality and ARDL modeling approach -- 21-Adoption of genomics and breeding strategies to improve goat productivity in Southern Africa.
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  • 48
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    Online-Ressource
    Drosophila Oogenesis : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Schlagwörter: Biological models. ; Developmental biology. ;