Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • PROTEIN  (9)
  • AREA-COMPOSITA  (5)
  • ARRHYTHMOGENIC CARDIOMYOPATHY  (2)
Collection
Keywords
  • 11
    Keywords: ANGIOGENESIS ; CELLS ; ENDOTHELIAL-CELLS ; IN-VITRO ; BLOOD ; Germany ; human ; IN-VIVO ; VITRO ; SYSTEM ; PROTEIN ; PROTEINS ; desmoplakin ; TISSUE ; COMPLEX ; COMPLEXES ; TISSUES ; beta-catenin ; TIGHT JUNCTIONS ; rodent ; JUNCTIONS ; LYMPHATIC ENDOTHELIUM ; RE ; DESMOSOMAL PLAQUE ; INTERCELLULAR-JUNCTIONS ; DESMOSOMAL PLAQUE PROTEINS ; SIZE ; ADHERENS JUNCTIONS ; BOVINE ; function ; lymph node ; LYMPH-NODE ; N-CADHERIN ; adhering junction ; VE-CADHERIN ; BLOOD-BRAIN-BARRIER ; Complexus adhaerens ; DESMOPLAKIN-CONTAINING JUNCTIONS ; HUMAN GLIOBLASTOMA-MULTIFORME ; retothelium ; TO-CELL JUNCTIONS
    Abstract: The significance of a special kind of VE-cadherin-based, desmoplakin- and plakoglobin-containing adhering junction, originally identified in certain endothelial cells of the mammalian lymphatic system ( notably the retothelial cells of the lymph node sinus and a subtype of lining endothelial cells of peripheral lymphatic vessels), has been widely confirmed and its importance in the formation of blood and lymph vessels has been demonstrated in vivo and in vitro. We have recently extended the molecular and structural characterization of the complexus adhaerens and can now report that it represents a rare and special combination of components known from three other major types of cell junction. It comprises zonula adhaerens proteins (VE-cadherin, alpha- and beta-catenin, protein p120(ctn), and afadin), desmosomal plaque components ( desmoplakin and plakoglobin), and tight-junction proteins (claudin-5 and ZO-1) and forms junctions that vary markedly in size and shape. The special character and the possible biological roles of the complexus adhaerens and its unique ensemble of molecules in angiogenesis, immunology, and oncology are discussed. The surprising finding of claudin-5 and protein ZO-1 in substructures of retothelial cell-cell bridges, i.e., structures that do not separate different tissues or cell layer compartments,suggests that such tight-junction molecules are involved in functions other than the "fence" and "barrier" roles of zonulae occludentes
    Type of Publication: Journal article published
    PubMed ID: 16372193
    Signatur Availability
    BibTip Others were also interested in ...
  • 12
    Keywords: PROTEIN ; TISSUE ; TUMORS ; MONOCLONAL-ANTIBODIES ; DESMOSOMAL PLAQUE ; RIGHT-VENTRICULAR CARDIOMYOPATHY ; ADHERENS JUNCTIONS ; EPITHELIAL DIFFERENTIATION ; adhering junctions ; HEART-MUSCLE CELLS ; plakophilin-2 ; AREA-COMPOSITA ; CYTOSKELETAL ARCHITECTURE ; PROTEIN PLAKOPHILIN-2 ; Myxomata ; Cardiac tumors ; Nuclear plakophilins
    Abstract: Within the characteristic ensemble of desmosomal plaque proteins, the protein plakophilin-2 (Pkp2) is known as a particularly important regulatory component in the cytoplasmic plaques of various other cell-cell junctions, such as the composite junctions () of the myocardiac intercalated disks and in the variously-sized and -shaped complex junctions of permanent cell culture lines derived therefrom. In addition, Pkp2 has been detected in certain protein complexes in the nucleoplasm of diverse kinds of cells. Using a novel set of highly sensitive and specific antibodies, both kinds of Pkp2, the junctional plaque-bound and the nuclear ones, can also be localized to the cytoplasmic plaques of diverse non-desmosomal cell-cell junction structures. These are not only the and the connecting various types of highly proliferative non-epithelial cells growing in culture but also some very proliferative states of cardiac interstitial cells and cardiac myxomata, including tumors growing in situ as well as fetal stages of heart development and cultures of valvular interstitial cells. Possible functions and assembly mechanisms of such Pkp2-positive cell-cell junctions as well as medical consequences are discussed
    Type of Publication: Journal article published
    PubMed ID: 22281687
    Signatur Availability
    BibTip Others were also interested in ...
  • 13
    Keywords: RIGHT-VENTRICULAR CARDIOMYOPATHY ; GAP-JUNCTIONS ; SUDDEN CARDIAC DEATH ; adhering junctions ; HEART-MUSCLE CELLS ; AREA-COMPOSITA ; Molecular composition ; RYANODINE RECEPTOR GENE ; ARRHYTHMOGENIC CARDIOMYOPATHY ; T-CATENIN
    Abstract: In a series of recent reports, mutations in the gene encoding a protein called LUMA (or TMEM43), widely speculated to be a tetraspan transmembrane protein of the nuclear envelope, have been associated with a specific subtype of cardiomyopathy (arrhythmogenic cardiomyopathies) and cases of sudden death. However, using antibodies of high specificity in immunolocalization experiments, we have discovered that, in mammals, LUMA is a component of zonula adhaerens and punctum adhaerens plaques of diverse epithelia and epithelial cell cultures and is also located in (or in some species associated with) the plaques of composite junctions (CJs) in myocardiac intercalated disks (IDs). In CJs, LUMA often colocalizes with several other CJ marker proteins. In all these cells, LUMA has not been detected in the nuclear envelope. Surprisingly, under certain conditions, similar CJ localizations have also been seen with some antibodies commercially available for some time. The identification of LUMA as a plaque component of myocardiac CJs leads to reconsiderations of the molecular composition and architecture, the development, the functions, and the pathogenic states of CJs and IDs. These findings now also allow the general conclusion that LUMA has to be added to the list of mutations of cardiomyocyte junction proteins that may be involved in cardiomyopathies.
    Type of Publication: Journal article published
    PubMed ID: 24770932
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...