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  • 101
    Online Resource
    Online Resource
    Hereditary Gastric and Breast Cancer Syndrome : CDH1: One Genotype with Multiple Phenotypes (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Cancer—Genetic aspects. ; Cancer—Treatment. ; Cancer. ; Medical screening. ; Oncology. ; Cancer Genetics and Genomics. ; Cancer Therapy. ; Cancer Screening. ; Oncology.
    In: Springer Nature eBook
    Description / Table of Contents: In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
    Type of Medium: Online Resource
    Pages: XV, 422 p. 58 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031213175
    URL: https://doi.org/10.1007/978-3-031-21317-5
    DOI: 10.1007/978-3-031-21317-5
    Language: English
    Note: Part I. Epidemiology -- Family History and the Risk of Breast and Gastric Cancer -- Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis -- Hereditary Lobular Breast Cancer: A Newly Defined Syndrome -- Part II. Genetics -- Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes -- CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes -- Revisiting the Biological and Clinical Impact of CDH1 Missense Variants -- Other Syndromes and Genes Associated with Gastric Cancer Predisposition -- Computer-Assisted Interpretation of Cancer-Predisposing Variants -- Part III. Pathology -- Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling -- HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations -- Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers -- Part IV. Endoscopy and Imaging -- Endoscopy: Is there Anything New? -- Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families -- Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon -- Part V. Surgery -- Prophylactic Total Gastrectomy: Techniques -- Prophylactic Total Gastrectomy: How Many? -- Hereditary Lobular Breast Cancer Syndrome: Role of Surgery -- Breast Reconstruction -- Part VI. New Issues -- Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis -- Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives -- The Chemoprevention of Hereditary Diffuse Gastric Cancer -- Malformations and Malformative Syndromes Associated with CDH1 -- Hereditary Breast Cancer Non-CDH1 Associated -- Part VII. Patient Advocacy -- My Hereditary Gastric Cancer -- Hereditary Breast Cancer Syndrome, My Experience -- Part VIII. Miscellaneous -- β-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.
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  • 102
    Online Resource
    Online Resource
    Textbook of Microbiology and Immunology (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Medical microbiology. ; Immunology. ; Bacteria. ; Virology. ; Microbial genetics. ; Medical Microbiology. ; Immunology. ; Bacteria. ; Virology. ; Microbial Genetics.
    In: Springer Nature eBook
    Description / Table of Contents: The fourth edition of “Textbook of Microbiology and Immunology” is an extensively revised edition, a healthy mixture of the old and the new contents. Many of the old traditional chapters have been retained with addition of new information along with the inclusion of new chapters more in line with the on-going changes in the syllabus and concepts in Medical Microbiology .While doing so, this book has blended the traditional organism-based learning and a syndrome based approach to infectious disease, together with the introduction of new and modified chapters incorporating the latest information in this field. The book provides an extensive coverage of fundamental topics in general and medical microbiology. The book also lays due emphasis on clinical microbiology with special focus on syndrome based approach to infectious diseases. It includes the basic concepts of microbiology as well as the recent updates and developments in the field of medical microbiology. All the topics have been incorporated in seven major sections: General microbiology, Immunology, Bacteriology, Virology, Mycology, and Applied and Clinical Microbiology. The dynamic nature of medical sciences with new guidelines and new diagnostic methods coming into the arena necessitates the incorporation of new information in each new edition of a book. This facet has been addressed with the inclusion of recent information on the various aspects of microbiology, infectious diseases and immunology, in the fourth edition of the Textbook of Microbiology and Immunology, which makes it one of the most authoritative and informative textbooks in medical microbiology. The book is an effort to inform and engage a wide spectrum of readers including medical students, both undergraduates and postgraduates, and residents, and faculty. It aims to be a must-have companion book for graduate and advanced undergraduate as well as postgraduate students of medical microbiology, general and allied microbiology, and of immunology.
    Type of Medium: Online Resource
    Pages: XXX, 1111 p. 1 illus. , online resource.
    Edition: 4th ed. 2023.
    ISBN: 9789811933158
    URL: https://doi.org/10.1007/978-981-19-3315-8
    DOI: 10.1007/978-981-19-3315-8
    Language: English
    Note: Part I. General Microbiology -- 1. Introduction and History of Microbiology -- 2. Classification, Nomenclature and Taxonomy of Microbes -- 3. Microscopy -- 4. Sterilisation and Disinfection -- 5. Microbial Genetics -- 6. Human Normal Microbial Flora and Microbiome -- 7. Microbial Infections -- 8. Diagnostic Methods in Microbial Infections -- 9. Genomics, Proteomics and Molecular Biology in Microbiology -- Part II. Immunology -- 10. Immunity -- 11. Structure and Function of Immune System -- 12. Antigen -- 13. Antibodies -- 14. Complement System -- 15. Antigen–Antibody Reactions -- 16. Immune Response -- 17. Hypersensitivity -- 18. Autoimmunity -- 19. Immunodeficiency Diseases -- 20. Immunology of Transplantation and Malignancy -- 21. Immunohaematology and Immunoprophylaxis -- Part III. Bacteriology -- 22. Introduction to Bacteriology -- 23. Antimicrobial Therapy -- 24. Laboratory Diagnosis of Bacterial Diseases -- 25. Staphylococcus -- 26. Streptococcus, Enterococcus and Pneumococcus -- 27. Neisseria and Moraxella -- 28. Corynebacterium and Coryneform Bacteria -- 29. Bacillus -- 30. Mycobacterium tuberculosis -- 31. Mycobacterium leprae, Mycobacterium lepraemurium and Non-tuberculosis Mycobacteria -- 32. Actinomycetes -- 33. Clostridium -- 34. Non-Sporing Anaerobes -- 35. Coliforms -- 36. Salmonella and Shigella -- 37. Yersinia, Pasteurella and Francisella -- 38. Pseudomonas, Burkholderia and Acinetobacter -- 39. Vibrio, Aeromonas and Plesiomonas -- 40. Haemophilus and Bordetella -- 41. Brucella -- 42. Campylobacter and Helicobacter -- 43. Treponema, Borrelia and Leptospira -- 44. Rickettsiaceae, Orientia, Ehrlichia and Coxiella -- 45. Mycoplasma and Ureaplasma -- 46. Chlamydia and Chlamydophila -- 47. Miscellaneous Bacteria -- Part IV. Virology -- 48. Introduction to Viruses -- 49. Antiviral Agents -- 50. Laboratory Diagnosis of Viral Diseases -- 51. Bacteriophages -- 52. Poxviruses -- 53. Herpesviruses -- 54. Adenoviruses -- 55. Picornaviruses -- 56. Orthomyxoviruses -- 57. Paramyxoviruses -- 58. Arboviruses (Arthropod-borne Viruses) and Rodent-borne -- 59. Rhabdoviruses -- 60. Hepatitis Viruses -- 61. Retrovirus -- 62. Slow Virus and Prion Diseases -- 63. Oncogenic Viruses -- 64. Miscellaneous Viruses -- Part. V Mycology -- 65. Introduction to Mycology -- 66. Superficial, Cutaneous and Subcutaneous Mycoses -- 67. Systemic Mycoses and Opportunistic Infections -- Part VI. Applied and Clinical Microbiology -- 68. Bacteriology of Water, Milk, Air and Food -- 69. Biomedical Waste Management -- 70. Healthcare-Associated Infections -- 71. Infective Syndromes: A System and Organ-Based Approach -- 72. Quality Assurance in Diagnostic Microbiology -- Glossary -- Further Readings -- Index.
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  • 103
    Online Resource
    Online Resource
    Essentials of Cerebellum and Cerebellar Disorders : A Primer For Graduate Students (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Neurosciences. ; Neuroanatomy. ; Neurophysiology. ; Developmental neurobiology. ; Cognitive neuroscience. ; Neuroscience. ; Neuroanatomy. ; Neurophysiology. ; Development of the Nervous System. ; Cognitive Neuroscience.
    In: Springer Nature eBook
    Description / Table of Contents: This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
    Type of Medium: Online Resource
    Pages: XIV, 742 p. 182 illus., 127 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031150708
    URL: https://doi.org/10.1007/978-3-031-15070-8
    DOI: 10.1007/978-3-031-15070-8
    Language: English
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  • 104
    Online Resource
    Online Resource
    Nasal Drug Delivery : Formulations, Developments, Challenges, and Solutions (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Drug delivery systems. ; Pharmaceutical chemistry. ; Pharmacology. ; Drug Delivery. ; Pharmaceutics. ; Pharmacology.
    In: Springer Nature eBook
    Description / Table of Contents: This book addresses the recent trends and clinical research being reported in last 5 to 10 years in the field of nasal drug delivery systems. In recent years, interest in using nasal passage as drug absorption site has received increased attention from formulation scientists. Nasal passages, even though a small surface area of the body as compared to other absorption passage such as Gastrointestinal tract or skin, show significant possibility for drug absorption at a quicker rate. There is also a possibility of delivering drugs to the brain using this passage and targeting drugs through the nasal passage. The book has 19 chapters addressing various aspects of nasal drug delivery systems such as an overview of anatomy and physiology of the nasal passage from a drug delivery point of view to global market opportunities for nasal drug delivery. In between, it addresses various aspects of nasal drug delivery. There are very few titles exclusively dedicated to nasal drug delivery, covering the formulation and developmental aspects, and addressing the challenges and solutions. The primary audiences for the book are graduate students in field of medicine, pharmacy and also various researchers who are working in the area of nasal drug delivery in addition to students who are specializing in field of medicine in ENT. This book provides comprehensive information on all the aspects related to the nasal drug delivery of various drug molecules.
    Type of Medium: Online Resource
    Pages: XIV, 420 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031231124
    URL: https://doi.org/10.1007/978-3-031-23112-4
    DOI: 10.1007/978-3-031-23112-4
    Language: English
    Note: An Overview of the Anatomy and Physiology of the Nasal Passage from a Drug Delivery Point of View -- Pharmacological and Clinical Problems with a Special Focus on Nasal Drug Delivery -- Nasal as an Absorption Site: Opportunities and Challenges -- Factors Affecting the Design of Nasal Drug Delivery Systems -- Challenges in Targeting to the Nasal Passage -- Potential Targeting Sites to Brain Through the Nasal Passage -- Drug Absorption to Systemic Circulation after Nasal Drug Delivery -- Delivery of Vaccine through Nasal Drug Delivery System -- An Overview on Nano Carriers for Nasal Delivery -- Biomedical Applications of Nano Carriers in Nasal delivery -- Novel muco-adhesive polymers for nasal drug delivery -- Novel approaches in Nasal in situ gel drug delivery -- Nasal delivery of high molecular weight drugs recent trends and clinical evidence -- Nisosomes based drug delivery in targeting the brain tumors via nasal delivery -- Nano suspension- A Novel Drug Delivery System via Nose to Brain drug delivery -- Different Strategies for nose-to-brain delivery of protein and peptide molecules -- Regulatory requirements related to Nasal drug delivery -- Is there a global market and opportunities for nasal drug delivery. .
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  • 105
    Online Resource
    Online Resource
    Exercise, Respiratory and Environmental Physiology : A Tribute from the School of Milano (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Life sciences. ; Human physiology. ; Medicine—History. ; Life Sciences. ; Life Sciences. ; Human Physiology. ; History of Medicine.
    In: Springer Nature eBook
    Description / Table of Contents: This book sheds new light on the history of exercise physiology and how it essentially grew, thanks to the work of a few major Schools. Analysing and interpreting the evolution of the field, the authors focus on the School of Milano, which was founded by Rodolfo Margaria and is one of the most prominent representatives, having played a central role in promoting and advancing this field of physiology. In turn, the authors trace Margaria’s biography; under his influence, the school introduced new concepts with regard to both the energetics of muscular exercise and to human locomotion. These concepts were further developed by Margaria’s pupils and by subsequent generations. Indeed, the course that was set in Milano greatly influenced the entire history of modern physiology. Readers with a keen interest in the origins of modern concepts and technologies in exercise physiology will find this book a fascinating and informative read.
    Type of Medium: Online Resource
    Pages: XXI, 443 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031191978
    Series Statement: Perspectives in Physiology,
    URL: https://doi.org/10.1007/978-3-031-19197-8
    DOI: 10.1007/978-3-031-19197-8
    Language: English
    Note: Chapter 1. Before Margaria: Mosso and Herlitzka -- Chapter 2. Margaria’s Revolution: A Novel Energetic View of Muscular Contraction -- Chapter 3. Margaria’s Concept of Oxygen Debt -- Chapter 4. Further Developments on Exercise Transients: Los Angeles Versus Milano -- Chapter 5. The Energetics and Biomechanics of Walking and Running -- Chapter 6. Cycling, Swimming and Other Forms of Locomotion on Land and in Water -- Chapter 7. Maximal Oxygen Consumption -- Chapter 8. Respiratory Mechanics -- Chapter 9. The Air–Blood Barrier -- Chapter 10. A School Goes to Altitude -- Chapter 11. A School Goes into Space -- Chapter 12. A School Goes into Depth.
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  • 106
    Online Resource
    Online Resource
    Glycosignals in Cancer : Molecular Assembly and Recognition (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Medicine—Research. ; Biology—Research. ; Medical genetics. ; Life sciences. ; Cytology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Life Sciences. ; Cell Biology. ; Internal Medicine.
    In: Springer Nature eBook
    Description / Table of Contents: This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Type of Medium: Online Resource
    Pages: VI, 238 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811977329
    URL: https://doi.org/10.1007/978-981-19-7732-9
    DOI: 10.1007/978-981-19-7732-9
    Language: English
    Note: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
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  • 107
    Online Resource
    Online Resource
    Nanotoxicology in Nanobiomedicine (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Toxicology. ; Nanomedicine. ; Nanobiotechnology. ; Toxicology. ; Nanomedicine and Nanotoxicology. ; Medical Toxicology. ; Nanobiotechnology.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides that knowledge needed to introduce individuals to the most important research and content on nanotoxicology in nanobiomedicine. Nanotechnology is helping to considerably improve, even revolutionize many technology and industry sectors: information technology, homeland security, medicine, transportation, energy, food safety, and environmental science, among many others. There is an urgent need for a general reference textbook that presents the most recent information on the toxicity and its effects in all these sectors, biomedicine in particular. It includes historical information, nanotoxicology by subject area and or disease, sources of nanomaterials, drug delivery systems and more. Scientists, researchers, and students in all fields that use nanotechnology will find this book essential reading.
    Type of Medium: Online Resource
    Pages: XVII, 179 p. 45 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031242878
    URL: https://doi.org/10.1007/978-3-031-24287-8
    DOI: 10.1007/978-3-031-24287-8
    Language: English
    Note: Introduction -- Terminology -- nano -- polymer nanoparticles -- Nonpolymer nanoparticles -- Nanodevices -- Hybrid materials -- Nanocomposite -- Biomedical -- Further Reading -- Historical Development and Future Trends -- introduction -- Early Period -- Premodern period -- Middle Ages -- Modern Nanotechnology -- Regulations.-Scientific Trends -- Future Trends.-Small Systems Big Applications -- Smart Pills -- Beating the Big C -- Further Reading -- Sources and Classifications -- Introduction -- Properties -- Nanomaterials and Bulk Materials -- Sources -- Naturally produced -- Incidental -- Engineered Nanomaterials.-Classifications -- Natural NPs/NMs -- Incidental NPs -- Synthetic (Engineered) Nanomaterials (NMS) -- Dimensions Based Nanomaterials -- Nanoparticles -- Nanoclays -- nanoemulsions -- Further Reading -- Synthesis, Detection and Characterization -- Introduction -- Production Approaches -- Synthesis -- Physical Methods -- Chemical Methods -- Biological Approach -- magnetic nps -- Hybrid nanomaterials -- nanocomposites.-Detection -- Characterization and isolation -- Direct Techniques -- indirect Techniques -- Key Issues in Fabrication -- Further Reading -- Mechanisms of Nanotoxicty -- introduction -- Entry Sites and Uptake -- Elimination -- Phagocytosis -- Macropinocytosis -- Other Entry Mechanisms -- Intracellular Trafficking -- Trojan Horse Mechanism -- Cellular Exocytosis -- Cellular Dysfunction -- Inorganic Nanomaterial Toxicity -- Cell Deaths -- Further Readings -- Applications-. Introduction -- Nanoparticle-Based Technologies-. Agriculture -- Energy and Environment -- Materials Science and Engineering -- Materials Science and Engineering -- Health and Medicine -- Hybrid Nanomaterials -- Nanocomposites -- Further Reading -- Nano Based Drug Delivery Systems -- Introduction -- Overview in Biomedical Science -- properties of NP Drug Delivery -- Factors influencing Drug Laden Nanocarriers -- pH Specificity -- Temperature Specificity -- Temperature Specificity -- Advantages of Delivery Vehicles -- Nanocarriers -- Passive Targeting -- Active Targeting -- Uses and Applications -- Delivery Vehicles -- Organic Nanomaterials.-Poly-alkyl-cyano-acrylates (PAC) -- Artificial DNA Nanostructures -- Nanocomposites -- Hybrid nanoparticles -- Further Reading.-Tissue Engineering in Dentistry -- Introduction -- Materials for Dental Applications -- Structure and Periodontal Tissue -- Factors Affecting Bone Tissue Regeneration -- Periodontal Diseases -- Tissue Engineering -- Procedure -- Assembly Methods -- Bone Tissue Engineering -- Stem Cell Sources -- Signaling Molecules -- Scaffold/Matrices -- Bioactive Glasses -- Metal-Based materials -- Polymers -- Composites -- Scaffoldfree Techniques -- Biocompatibility -- Drug or Signaling Molecules Delivery -- Future Prospectives -- Further Reading -- Nanobiosensors -- Introduction -- Variations and Types -- Nanoparticle Based Sensors -- Nanotube Based Sensors -- Nanowire Based Sensors -- Components of a typical Biosensors -- Selection and Optimization -- -- Applications -- Cancer -- Detection of diabetes -- Immunoassay (detection of Ab-Ag reaction) -- Detection of pathogenic bacteria -- Future Prospects -- Further Reading -- Health and Medicine -- Introduction -- Keywords -- Nanostructures -- Polymers or Organic NPs -- Nonpoymers or Inorganic Nanoparticles -- Health and Medicine -- Neurodegenerative Disorders -- Tuberculosis -- Ophthalmology -- Respiratory diseases -- Surgery -- Toxicity -- Conclusion -- Further Reading Multiple Choice Questions. .
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  • 108
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    Online Resource
    Thermogenic Fat : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Medicine—Research. ; Biology—Research. ; Physiology. ; Stem cells. ; Biomedical Research. ; Physiology. ; Stem Cell Biology.
    In: Springer Nature eBook
    Description / Table of Contents: This volume presents a broad collection of state-of-the-art methods to study the biology of thermogenic fat using in vitro cell culture and animal models. Chapters guide the readers through protocols on differentiation of human pluripotent stem cells and murine adipocyte precursors; methods for measuring mitochondrial respiration, heat generation, brown fat activation, and effects on energy metabolism in mice; and techniques for AAV-mediated gene delivery, transplantation of adipose tissue, isolation of adipose tissue immune cells and extracellular vesicles, and mass spectrometry-based profiling of brown fat lipids. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Thermogenic Fat: Methods and Protocols aims to be comprehensive guide for researchers in the field.
    Type of Medium: Online Resource
    Pages: XII, 253 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071631676
    Series Statement: Methods in Molecular Biology, 2662
    URL: https://doi.org/10.1007/978-1-0716-3167-6
    DOI: 10.1007/978-1-0716-3167-6
    Language: English
    Note: Differentiation of Human Pluripotent Stem cells (hPSCs) into Brown-Like Adipocytes -- Culture and Differentiation of Primary Preadipocytes from Mouse Subcutaneous White Adipose Tissue -- Isolation and Differentiation of Adipocyte Precursors Derived from Neonatal Murine Brown Adipose Tissue -- Determination of Adipocyte Size and Number -- Measuring Mitochondrial Uncoupling in Mouse Primary Brown Adipocytes Differentiated ex vivo -- Assessment of Bioenergetics in BAT Mitochondria -- Use of Isothermal Microcalorimetry to Measure Cellular Heat Production in Thermogenic Adipocytes -- Measurement of Intracellular Temperature in Brown Adipocytes using a Cationic Fluorescent Polymeric Thermometer -- Indirect Calorimetry to Assess Energy Balance in Mice: Measurement and Data Analysis -- Thermogenic Phenotyping in Mice -- Calculating Diet-Induced Thermogenesis in Mice -- Assessment of Brown and Beige Adipose Tissue Activation in Mice using PET/CT Imaging -- Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies -- Use of CIDEA Reporter Mouse Model for Screening Thermogenic Fat Activating Drugs -- AAV-Mediated Gene Delivery to Mouse Brown Adipose Tissue -- Subcutaneous Transplantation of White Adipose Tissue -- Brown Adipose Tissue Transplantation -- Isolation and Characterization of Brown Adipose Tissue T Cells -- Isolation of Adipose Tissue Extracellular Vesicles -- Isolation and Mass Spectrometry-Based Profiling of Major Lipids in Brown Adipose Tissue -- Methods for Single Cell Transcriptomic Analysis of Adipose Tissue.
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  • 109
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    The Immune Synapse : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Biology—Technique. ; Experimental immunology. ; Immunology. ; Cytology. ; Immunological Techniques. ; Immunology. ; Cell Biology.
    In: Springer Nature eBook
    Description / Table of Contents: This new collection features the most up-to-date essential protocols that are currently being used to study the immune synapse. Beginning with methods for making biophysical measurements, the volume continues by covering the cell biology of synapses, methods for advanced substrate engineering, mechanobiology topics, new technologies to describe and manipulate synaptic components, as well as methods related to sites of action and immunotherapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and fully updated, The Immune Synapse: Methods and Protocols, Second Edition serves as an ideal practical guide for researchers working in this dynamic field. Chapters 5, 11, 18, 27, 30, and 32 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVI, 516 p. 115 illus., 105 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9781071631355
    Series Statement: Methods in Molecular Biology, 2654
    URL: https://doi.org/10.1007/978-1-0716-3135-5
    DOI: 10.1007/978-1-0716-3135-5
    Language: English
    Note: Measuring the Co-Localization and Dynamics of Mobile Proteins in Live Cells Undergoing Signaling Responses -- Fluorescence-Based Measurements of Two-Dimensional Affinity in Membrane Interfaces -- Surfaces for Study of Receptor Dynamics on T Cells -- Molecular Dynamics Simulations of Immune Receptors and Ligands -- Investigating Diffusion Dynamics and Interactions with Scanning Fluorescence Correlation Spectroscopy (sFCS) -- Combined FRET-FLIM and NAD(P)H FLIM to Analyze B Cell Receptor Signaling Induced Metabolic Activity of Germinal Center B Cells In Vivo -- Measurement of Molecular Height Using Cell Surface Optical Profilometry (CSOP) -- Observing Membrane and Cell Adhesion via Reflection Interference Contrast Microscopy (RICM) -- En-Face-Imaging of T Cell-Dendritic Cell Immunological Synapses -- High and Super Resolution Imaging of Cell-Cell Interfaces -- Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immuno-Isolation -- Microvillar Cartography: A Super-Resolution Single-Molecule Imaging Method to Map the Positions of Membrane Proteins with Respect to Cellular Surface Topography -- T Cell Immunological Synaptosomes: Definition and Isolation -- Dynamics of Immune Cell Microvilli -- Visualization of Myddosome Assembly in Live Cells -- Detection of Telomere Transfer at Immunological Synapse -- Bottom-Up Assembly of Bio-Inspired, Fully Synthetic Extracellular Vesicles -- A DNA Origami-Based Biointerface to Interrogate the Spatial Requirements for Sensitized T-Cell Antigen Recognition -- Leveraging DNA Origami to Study Phagocytosis -- Fabrication of Nanoscale Arrays to Study the Effect of Ligand Arrangement on Inhibitory Signaling in NK Cells -- Measurement of Forces for Trans-Endocytosis at Dorsal and Ventral Sides of the Cell -- Functionalized Lipid Droplets and Microfluidics Approach to Study Immune Cell Polarity In Vitro -- Quantifying Immune Cell Force Generation Using Traction Force Microscopy -- Characterizing Biophysical Parameters of Single TCR-pMHC Interactions Using Optical Tweezers -- Isolation of the B Cell Immune Synapse for Proteomic Analysis -- Analyzing Single Cell Secretions by ‘Shadow Imaging’ -- Exploiting the RUSH System to Study Lytic Granule Biogenesis in Cytotoxic T Lymphocytes -- Interactions of Tissue Resident T Cells -- Live Imaging of CAR T Cell Ca2+ Signals in Tumor Slices Using Confocal Microscopy -- Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse -- In Vitro Generation of Human Tolerogenic Monocyte-Derived Dendritic Cells -- Methods of Machine Learning-Based Chimeric Antigen Receptor Immunological Synapse Quality Quantification -- Imaging CAR-T Synapse as a Quality Control for CAR Engineering.
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  • 110
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    DNA and RNA Origami : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Medical genetics. ; Nanochemistry. ; Medical Genetics. ; Nanochemistry.
    In: Springer Nature eBook
    Description / Table of Contents: This volume detials diverse methodological approaches on the assembly and applications of DNA origami assemblies. Chapters guide readers through different synthetic and computational methods, isolation and structural characterization of 2D and 3D DNA origami nanoarchitectures, nanophotonics, drug delivery, biophysics, and synthetic biology.Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA and RNA Origami: Methods and Protocols aims to serve as a guideline describing the current state-of-the-art assembly methodologies and applications of DNA origami nanostructures.
    Type of Medium: Online Resource
    Pages: XII, 353 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071630280
    Series Statement: Methods in Molecular Biology, 2639
    URL: https://doi.org/10.1007/978-1-0716-3028-0
    DOI: 10.1007/978-1-0716-3028-0
    Language: English
    Note: DNA Origami: Recent Progress and Applications -- Design, Assembly, and Function of DNA Origami Mechanisms -- Computer-aided design and Functionalization of ssRNA Origami Structures -- Reconfigurable Two-dimensional DNA Molecular Arrays -- Two-dimensional DNA origami lattices assembled on lipid bilayer membranes -- The oxDNA coarse-grained model as a tool to simulate DNA origami -- All-atom Molecular Dynamics Simulations of Membrane Spanning DNA Origami Nanopores -- Single molecule imaging of enzymatic reactions on DNA origami -- Single-molecule nanomechanical genotyping with DNA origami-based shape IDs -- Using single molecule FRET to evaluate DNA nanodevices at work -- Parallel Functionalization of DNA Origami -- Protein Coating of DNA Origami -- Cellular uptake of DNA origami -- Binding and characterization of DNA origami nanostructures on lipid membranes -- Electrical actuation of DNA based nanomechanical systems -- Enzyme cascade reactions on DNA origami scaffold -- Aptamers as Functional Modules for DNA Nanostructures -- Production and Testing of RNA Origami Anticoagulants. .
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    The Mitoribosome : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Genetics. ; Genetics.
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides classic and new methods to study the structure, assembly pathway, and protein synthesis ability of mitoribosomes across species. Following an introduction of fundamental concepts on the topic, method chapters present detailed protocols based on cryo-electron tomography, cryo-EM approaches, mitoribosome purification techniques, mitochondrial translation assays, and methods to study mitochondrial mRNAs that are translated on mitoribosomes. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Mitoribosome: Methods and Protocols, aims to be a comprehensive guide for researchers in the field.
    Type of Medium: Online Resource
    Pages: XI, 346 p. 41 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071631713
    Series Statement: Methods in Molecular Biology, 2661
    URL: https://doi.org/10.1007/978-1-0716-3171-3
    DOI: 10.1007/978-1-0716-3171-3
    Language: English
    Note: Discovery of Mitochondrial Ribosomes -- Evolution: Mitochondrial Ribosomes across Species -- Mitoribosome Biogenesis -- Translation in Mitochondrial Ribosomes -- Sample Preparation of Isolated Mitochondria for Cryoelectron Tomography and in situ Studies of Translation -- Cryo-EM for Structure Determination of Mitochondrial Ribosome Samples -- Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA -- Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipitation -- Rapid Cryo-Purification of the Yeast Mitochondrial Ribosome -- Methods to Study the Biogenesis of Mitoribosomal Proteins in Yeast -- Systematic Analysis of Assembly Intermediates in Yeast to Decipher the Mitoribosome Assembly Pathway -- Metabolic Labelling of Mitochondrial Translation Products in Whole Cells and Isolated Organelles -- Assembly of the Mitochondrial Translation Initiation Complex -- Reconstitution of Mammalian Mitochondrial Translation System Capable of Long Polypeptide Synthesis -- Human Mitoribosome Profiling: a Re-engineered Approach Tailored to Study Mitochondrial Translation -- The ARG8m Reporter for the Study of Yeast Mitochondrial Translation -- Four Colour Super-Resolution RNA Fluorescent In Situ Hybridization and Immunocytochemistry to Visualise Mitochondrial mRNAs in Context with Mitochondrial Ribosomes -- Digital RNase Footprinting of RNA-protein Complexes and Ribosomes in Mitochondria -- Dead-seq: Discovering Synthetic Lethal Interactions from Dead Cells Genomics.
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    RNA-Protein Complexes and Interactions : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Genetics. ; Genetics and Genomics.
    In: Springer Nature eBook
    Description / Table of Contents: This second edition updates, complements, and expands upon the first edition by providing a collection of cutting-edge techniques developed or refined in the past few years along with tried-and-true methods. Chapters explore the isolation and characterization of RNA-protein complexes, the analysis and measurement of RNA-protein interaction, and related novel techniques and strategies. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to the material, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section which highlights tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA-Protein Complexes and Interactions: Methods and Protocols, Second Edition aims to be comprehensive guide for researchers in the field.
    Type of Medium: Online Resource
    Pages: XV, 349 p. 70 illus., 55 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9781071631911
    Series Statement: Methods in Molecular Biology, 2666
    URL: https://doi.org/10.1007/978-1-0716-3191-1
    DOI: 10.1007/978-1-0716-3191-1
    Language: English
    Note: In vivo cross-linking and co-immunoprecipitation procedure to analyze nuclear tRNA export complexes in yeast cells -- Analysis of Gene Expression Patterns and RNA Localization by Fluorescence in situ Hybridization in Whole Mount Drosophila Testes -- Electrophoretic mobility shift assay (EMSA) and microscale thermophoresis (MST) methods to measure interactions between tRNAs and their modifying enzymes -- Mapping of RNase P ribozyme regions in proximity with a human RNase P subunit protein using Fe(II)-EDTA cleavage and nuclease footprint analyses -- SHAPE to probe RNA structure and RNA-protein interactions in vitro -- Chemical probing of RNA structure in vivo using SHAPE-MaP and DMS-MaP -- Analysis of RNA-protein interaction networks using RNP-MaP -- Native RNA immunoprecipitation (RIP) for precise detection and quantification of protein-interacting RNA -- In vivo cross-linking and co-immunoprecipitation procedure to analyze nuclear tRNA export complexes in yeast cells -- Identify microRNA targets using AGO2-CLASH (Cross-linking, Ligation, And Sequencing of Hybrids) and AGO2-CLIP (Cross-Linking and Immuno-Precipitation) in cells with or without the microRNA of interest depleted -- Ribosomal Profiling by Gradient Fractionation of Cell Lysates -- Global assessment of protein translation in mammalian cells using polysome fractionation -- Fluorescent in situ detection of RNA-Protein interactions in intact cells by RNA-PLA -- Arresting Spliceosome Intermediates at Various Stages of the Splicing Pathway -- Streamlined purification of RNA-protein complexes using UV crosslinking and RNA antisense purification -- MS2-MBP based affinity purification of nucleus- or cytoplasm-localized lncRNA-protein complexes formed in vivo -- RNA and protein interactomes of an RNA-binding protein tagged with FLAG epitopes using combinatory approaches of genome engineering and stable transfection -- Detecting R-loop formation using a plasmid-based in vitro transcription assayMethods to Study RNA-Chromatin Interactions -- Challenges for Studying and Isolating Extracellular Vesicles from Cell-conditioned Media -- Evolution of Cell-Type-Specific RNA Aptamers Via Live Cell-Based SELEX.
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    Animal Models of Reproductive Behavior (2023)
    New York, NY : Springer US
    Details
    Subject(s): Neurosciences. ; Biological models. ; Neuroscience. ; Biological Models.
    In: Springer Nature eBook
    Description / Table of Contents: This volume presents the latest techniques to study several aspects of reproductive behavior in different species. The chapters in this book cover topics such as methods to investigate social behavior; sexual motivation and reward, both of which are fundamental for the initiation of sexual behavior; olfactory signaling; different characteristics and models of reproductive function; and parental behavior in both rats and rabbits. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Animal Models of Reproductive Behavior is a valuable resource for both experienced researchers and students who want to incorporate new techniques into their studies of reproductive behavior.
    Type of Medium: Online Resource
    Pages: XIII, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071632345
    Series Statement: Neuromethods, 200
    URL: https://doi.org/10.1007/978-1-0716-3234-5
    DOI: 10.1007/978-1-0716-3234-5
    Language: English
    Note: The Study of Social Cognition: Social Recognition and Social Learning in Laboratory Rats and Mice -- Social and Sexual Preference in Socially Monogamous Species: Prairie Voles (Microtus ochrogaster) and Zebra Finch (Taeniopygia guttata) -- Basic Protocols for the Study of Maternal Behavior in Rabbits -- Basic Protocols to Study Parental Behavior in Rats -- The Bruce Effect: Complementary Roles of Olfactory Memory and Male-Sourced Estradiol -- Open Source JL Olfactometer for Awake Behaving Recording of Brain Activity for Mice Engaged in Olfactory Tasks -- Resting-State Functional Magnetic Resonance Imaging as a Method for the Study of Social Behavior in a Rodent Model -- Evaluation of Sexual Behavior in Laboratory vs Seminatural Conditions -- Sexual Incentive Motivation -- Pro-Choice: Partner Preference as a Method to Assess Sexual Motivation -- Copulation in Rats: Analysis of Behavioral and Seminal Parameters -- Paced Mating Behavior -- Assessment of Sexual Reward with the Conditioned Place Preference Paradigm -- Because Sex Matters: The Case of Female Sexual Response -- Methods to Assess the Role of Neurogenesis in Reproductive Behaviors of Birds, Rats, and Sheep.
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    Polycomb Group Proteins : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Proteins. ; Proteins.
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the latest technologies used in the Polycomb Group of proteins field and helps scientists--working on PcG proteins--investigate all functions of PcG proteins in diverse cellular contexts. The chapters in this book cover topics such the distribution of histone marks by CUT&Tag in Drosophila embryos; Co-IP in mammalian cells; replication timing of gene loci in different cell cycle phases; STORM and electronmicroscopy and relative data analysis; and polycomb mediated epigenetic modification in spheroids. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Polycomb Group Proteins: Methods and Protocols, Second Edition is a valuable tool for all researchers looking to expand their knowledge of this developing field.
    Type of Medium: Online Resource
    Pages: XI, 246 p. 48 illus., 42 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9781071631430
    Series Statement: Methods in Molecular Biology, 2655
    URL: https://doi.org/10.1007/978-1-0716-3143-0
    DOI: 10.1007/978-1-0716-3143-0
    Language: English
    Note: Analyzing the Genome-Wide Distribution of Histone Marks by CUT&Tag in Drosophila Embryos -- Chromatin Preparation and Chromatin Immuno-Precipitation from Drosophila Heads -- Detecting Cell Compartment Specific PRC2-RNA Interactions via UV-RIP -- Chromosome Conformation Capture Followed by Genome-Wide Sequencing (Hi-C) in Drosophila Embryos -- Physics-Based Polymer Models to Probe Chromosome Structure in Single Molecules -- Co-Immunoprecipitation (Co-IP) in Mammalian Cells -- Site Directed Mutagenesis Protocol to Determine the Role of Amino Acid Residues in Polycomb Group (PcG) Protein Function -- Isolation of Chromatin Proteins by Genome Capture -- Dynamic Interactome of PRC2-EZH1 Complex Using Tandem-Affinity Purification and Quantitative Mass Spectrometry -- Replication Timing of Gene Loci in Different Cell Cycle Phases -- Polycomb Bodies Detection in Murine Fibromuscular Stroma from Skin, Skeletal Muscles, and Aortic Tissues -- Segmentation, 3D Reconstruction, and Analysis of PcG Proteins in Fluorescence Microscopy Images in Different Cell Culture Conditions -- STORM Microscopy and Cluster Analysis for PcG Studies -- Quantitative Analysis of PcG-Associated Condensates by Stochastic Optical Reconstruction Microscopy (STORM) -- Immunoelectron Microscopy Methods -- Differentiation of hPSCs to Study PRC2 Role in Cell-Fate Specification and Neurodevelopment -- Analysis of Polycomb Epigenetic Marks in HeLa Spheroids -- Establishment and Maintenance of Human CRC-Derived Organoids for PcGs Studies.
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    Hemostasis and Thrombosis : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Medicine—Research. ; Biology—Research. ; Hematology. ; Biomedical Research. ; Hematology.
    In: Springer Nature eBook
    Description / Table of Contents: This second edition volume expands on the previous edition with updates about the latest state-of-the-art techniques used in leading hemostasis and thrombosis laboratories for diagnosis and exclusion of hemorrhagic and thrombotic diseases. The chapters in this book are organized into seven parts. Part One provides a general overview on hemostasis and thrombosis, preanalytical issues in testing, and routine hemostasis assays. Part Two covers laboratory testing for thrombophilia, including reviews for activated protein C resistance, protein C, lupus anticoagulant testing, and antiphospholipid antibodies. Part Three addresses monitoring continuous anticoagulant infusions and measuring the effects of oral anti-thrombotic therapy. Part Four talks about heparin induced thrombocytopenia and vaccine induced immune thrombotic thrombocytopenia. Part Five and Six cover ADAMTS13 activity testing and new information on bleeding disorders such as chromogenic factor VIII assays, measurement of emicizumab, and treatment of hemophilia A and B. Finally, Part Seven discusses global assays, research applications, and postanalytical considerations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Hemostasis and Thrombosis: Methods and Protocols, Second Edition is a valuable resource for scientists and researchers struggling to identify the appropriate methods for hemostasis and thrombosis testing, or who seek additional expert guidance on such testing.
    Type of Medium: Online Resource
    Pages: XVIII, 821 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9781071631751
    Series Statement: Methods in Molecular Biology, 2663
    URL: https://doi.org/10.1007/978-1-0716-3175-1
    DOI: 10.1007/978-1-0716-3175-1
    Language: English
    Note: Hemostasis and Thrombosis: An Overview Focusing on Associated Laboratory Testing to Diagnose and Help Manage Related Disorders -- Preanalytical Variables in Hemostasis Testing -- Automation in the Thrombosis and Hemostasis Laboratory -- Ultracentrifugation for Coagulation Testing -- Harmonization of Hemostasis Testing Across a Large Laboratory Network: An Example from Australia -- Auto-Validation of Routine Coagulation/Hemostasis Assays with Reflex Testing of Abnormal Test Results -- Laboratory Testing of Hemostasis in Pregnancy: A Brief Overview -- Protocols for D-Dimer Measurements for Aid to Diagnosis or Exclusion of Venous Thromboembolism -- Performance and Interpretation of Clot Waveform Analysis -- Laboratory Evaluation of Thrombophilia -- Laboratory Testing for Activated Protein C Resistance (APCR): An Update -- Evaluation of Activated Protein C Resistance using Thrombin Generation Test -- Performance of Chromogenic Protein C (PC) Testing -- Testing for Factor V Leiden (FVL) and Prothrombin G20210A Genetic Variants -- An Overview of Laboratory Testing for Antiphospholipid Antibodies -- Lupus Anticoagulant Testing: Taipan Snake Venom Time with Ecarin Time as Confirmatory Test -- Lupus Anticoagulant Testing: Dilute Prothrombin Time (dPT) -- An Acute Need Inspiration: Autoneutralization of Lupus Anticoagulants in Affected Prothrombin Times (PT) and Activated Partial Thromboplastin Times (APTT) -- Antiphospholipid Antibody Testing for Anti-Cardiolipin and Anti-2Glycoprotein I Antibodies using Chemiluminescence-Based Panels -- Laboratory Testing for Non-Criteria Antiphospholipid Antibodies-Antiphosphatidylserine/Prothrombin Antibodies (aPS/PT) -- Laboratory Testing for Non-Criteria Antiphospholipid Antibodies: Antibodies Towards the Domain One of Beta2-Glycoprotein I (aDI) -- An Overview of Heparin Monitoring with the Anti-Xa Assay -- Ecarin Based Methods for Measuring Thrombin Inhibitors -- Assays to Monitor Bivalirudin -- Monitoring of Anti-Platelet Therapy -- Heparin Induced Thrombotic Thrombocytopenia (HITT) and Vaccine Induced Immune Thrombotic Thrombocytopenia (VITT): Similar by Different -- Functional Testing for Heparin Induced Thrombocytopenia using Whole Blood Multiplate Impedance Aggregometry -- Multiple Electrode Aggregometry (Multiplate): Functional Assay for Vaccine Induced (Immune) Thrombotic Thrombocytopenia (VITT) -- Whole Blood Procoagulant Platelet Flow Cytometry Protocol for Heparin-Induced Thrombocytopenia (HIT) and Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Testing -- Serotonin Release Assay: Functional Assay for Heparin and Vaccine Induced (Immune) Thrombotic Thrombocytopenia -- An Overview of Laboratory Testing for ADAMTS13 -- Automated and Rapid ADAMTS13 Testing using Chemiluminescence: Utility for Identification or Exclusion of TTP and Beyond -- Identification of ADAMTS13 Inhibitors in Acquired TTP -- ADAMTS13 Activity: Screening Test Protocol -- ADAMTS13 Activity Measurement by ELISA and Fluorescence Resonance Energy Transfer Assay -- ADAMTS13 Antibody and Inhibitor Assays -- A Review of Factor VIII and Factor IX Assay Methods for Monitoring Extended Half-Life Products in Haemophilia A and B -- Measuring Emicizumab Levels in the Hemostasis Laboratory -- Chromogenic Factor VIII Assay for Patients with Haemophilia A and On Emicizumab Therapy -- Assessment of Platelet Function by Automated Light Transmission Aggregometry -- Assessment of Platelet Function by High-Throughput Screening Light Transmittance Aggregometry: Optimul Assay -- Preparing Surrogate Abnormal Quality Samples for Platelet Function Studies and Viscoelastic Testing -- Laboratory Testing for von Willebrand Disease Using a Composite Rapid 3-Test Chemiluminescence-Based von Willebrand Factor Assay Panel -- Laboratory Testing for von Wilebrand Factor Activity by a Glycoproein Ib Binding Assay (VWF:GPIbR): HemosIL von Willebrand Factor Ristocetin Cofactor Activity on ACL TOP® -- Laboratory Testing for von Willebrand Factor:Factor VIII Binding for Diagnosis or Exclusion of Type 2N von Willebrand Disease: An Update -- Automation of a Factor XIII Activity Assay Utilizing a Plasma Blank Measurement -- Measurement of Blood Viscoelasticity using Thromboelastography -- The TEG 5000© System: System Description and Protocol for Measurements -- The TEG 6s© System: System Description and Protocol for Measurements -- The Quantra® System: System Description and Protocols for Measurements -- Modified Rotational Thromboelastometry Protocol using Tissue Plasminogen Activator for Detection of Hypofibrinolysis and Hyperfibrinolysis -- Protocol for the Investigation of Plasma and Whole Blood Clot Property of Fibrin Fiber Thickness using Scanning Electron Microscopy -- Post-Analytical Issues in Hemostasis and Thrombosis Testing: An Update.
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    Advanced Automation for Tree Fruit Orchards and Vineyards (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Agriculture. ; Control engineering. ; Robotics. ; Automation. ; Geographic information systems. ; Food science. ; Agriculture. ; Control, Robotics, Automation. ; Geographical Information System. ; Food Science.
    In: Springer Nature eBook
    Description / Table of Contents: Modern tree fruit orchards and vineyards constitute complex production systems that are exposed to highly dynamic and stochastic natural, financial and societal forces, and face demands for increased production using fewer resources, with reduced environmental impact. Successful operation of orchards and vineyards under these conditions is practically impossible without careful and extensive use of state-of-the-art automation technologies and careful planning of future operations (e.g., training systems when replanting) that can be enabled by knowledge of emerging technologies and future trends. Also, improvement of existing automation technologies and development of novel future systems cannot be accomplished without a working understanding of the tree and vine biological production systems, their management needs, and the capabilities and limitations of existing automation systems. The book aims to provide the necessary knowledge to achieve the above goals in a way that can engage readers without engineering or horticultural backgrounds. .
    Type of Medium: Online Resource
    Pages: VII, 241 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031269417
    Series Statement: Agriculture Automation and Control,
    URL: https://doi.org/10.1007/978-3-031-26941-7
    DOI: 10.1007/978-3-031-26941-7
    Language: English
    Note: Fundamentals of Tree and Vine Physiology -- Mechanical Management of Modern Planar Fruit Tree Canopies -- Orchard Water Management -- Vineyard Water Management -- Pests and diseases management -- Advanced Technologies for Crop-load Management -- Mechanical Harvesting -- Autonomous Platforms -- Management Information Systems and Emerging Technologies -- Economic and Societal Aspects.
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    COVID-19 and Sleep: A Global Outlook (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Neurosciences. ; Public health. ; Medicine—Research. ; Biology—Research. ; Neuroscience. ; Public Health. ; Biomedical Research.
    In: Springer Nature eBook
    Description / Table of Contents: This book examines the correlation of the coronavirus disease-19 [CE1] [AAS2] (COVID-19) infection with sleep, circadian rhythm, and sleep disorders. The chapters of the book explore sleep problems during the COVID-19 pandemic and its association with psychological distress and also review the prevalence of clinical cases of insomnia, anxiety, and depression in COVID-19 patients. The book further presents the correlation between sleep, circadian rhythms, and immunity that contributes toward more severe COVID-19. It summarizes the evidence on the interplay between circadian biology, sleep, and COVID-19. The chapters of the book discuss the relationship between obstructive sleep apnea (OSA) and adverse COVID-19 outcomes. Towards the end, the book presents studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin and provides mechanistic insights into the potential therapeutic use of melatonin during the SARS-CoV-2 infection. The last chapter describes the publication output of sleep-related research during the pandemic and provides an overview and trends on sleep and covid-19 publication output. This book is an excellent source for neurologists, sleep specialists, and public health specialists.
    Type of Medium: Online Resource
    Pages: XXVI, 430 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819902408
    Series Statement: Progress in Sleep Research,
    URL: https://doi.org/10.1007/978-981-99-0240-8
    DOI: 10.1007/978-981-99-0240-8
    Language: English
    Note: 1. The effect of sleep disruption and circadian misalignment on the immune system -- 2. Changes in the sleep and circadian pattern of sleep during the COVID-19 pandemic -- 3. Anxiety and depression during the COVID-19 pandemic and their impact on sleep -- 4. Sleep problems during the COVID-19 pandemic in children and adolescents -- 5.Sleep problems during the COVID-19 pandemic in children and adolescents -- 6. Sleep disturbances among healthcare workers during the COVID-19 pandemic -- 7. Sleep disturbances among patients with COVID-19 infection -- 8. Sleep patterns and sleep disturbances during the lockdown periods -- 9. Impact of COVID-19 Mobility Restrictions on Sleep and Wellbeing -- 10. COVID-19 vaccines and sleep disturbances -- 11. Sleep during the COVID-19 pandemic: structural inequity and racial disparity -- 12. The effect of cognitive-behavioral therapy and coping strategies on sleep disturbances during the COVID-19 pandemic -- 13. Sleep and circadian rhythm in post-COVID-19 patients -- 14. COVID-19 and obstructive sleep apnea -- 15. The correlation between COVID-19 infection and restless legs syndrome -- 16. Impact of COVID-19 pandemic lockdown on disorders of hypersomnolence -- 17. Sleep, Physical Activity, and Diet Patterns During COVID-19 Pandemic -- 18. Impact of screen time during the pandemic of COVID-19 on sleep habits -- 19. Dreams and nightmares during the COVID-19 pandemic -- 20. The impact of the COVID-19 pandemic on sleep medicine services -- 21. Protocols for conducting sleep studies during pandemics -- 22. Management of hospital and home positive airway pressure machines during pandemics -- 23. Telemedicine and telemonitoring of sleep disorders during the COVID-19 pandemic -- 24.Changes in Positive Airway Pressure Application and Practices in Patients with Sleep-Related Breathing Disorder during the COVID-19 Pandemic -- 25. Potential Therapeutic Effects of Melatonin on SARS-CoV-2 Infection.
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    Handbook on Sourdough Biotechnology (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Food—Microbiology. ; Food science. ; Biotechnology. ; Biochemistry. ; Food Microbiology. ; Food Science. ; Biotechnology. ; Biochemistry.
    In: Springer Nature eBook
    Description / Table of Contents: Bread and leavened bakery products have been essential to human nourishment for millennia. Traditionally, bread production has relied on the use of sourdough as a leavening agent and to impart a characteristic quality to baked goods. In recent years, improved understanding of the biodiversity and microbial ecology of sourdough microbiota, the discovery of new species, the improved management and monitoring of its meta-community and the commercialization of innovative products have vastly expanded the potential of sourdough fermentation for making baked goods. For example, raw materials such as cereals, pseudo-cereals, ancient grains, and gluten-free substrates, as well as a large number of baked good varieties (e.g., typical and industrial breads, sweet baked goods, gluten-free products) may benefit from advances in sourdough fermentation. In addition, biotechnological tools and culture properties have been discovered to improve both the shelf life and the sensory and textural qualities of baked goods, as well as their nutritional and health-promoting properties. Now in its second edition, the Handbook on Sourdough Biotechnology remains the only book dedicated completely to sourdough biotechnology with the contribution of the most experienced researchers from the field. It reviews the history of sourdough and the potential of sourdough fermentation in the production of bread and baked goods. A thorough discussion of the various processing steps includes the chemical properties of the raw matter, the taxonomy, diversity, and metabolic properties of starter yeasts and lactic acid bacteria, and the effects of sourdough fermentation on the shelf life and the sensory, textural, nutritional, and health-promoting properties of baked goods.
    Type of Medium: Online Resource
    Pages: VI, 397 p. 47 illus., 26 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031230844
    URL: https://doi.org/10.1007/978-3-031-23084-4
    DOI: 10.1007/978-3-031-23084-4
    Language: English
    Note: 1. History and Social Aspects of Sourdough -- 2. The sourdough legislation -- 3. Chemistry of Cereal Grains -- 4. Technology of Sourdough Fermentation and Sourdough Applications -- 5. Steamed Bread -- 6. Taxonomy and Biodiversity of Sourdough Lactic Acid Bacteria -- 7. Taxonomy, Biodiversity and Physiology of Sourdough Yeasts -- 8. Physiology and Biochemistry of Lactic Acid Bacteria -- 9. Sourdough: A Tool to Improve Bread Flavor, Rheology and Shelf Life -- 10. Sourdough: A Tool for Non-Conventional Fermentation and To Recover Side Streams -- 11. Nutritional Aspects of Cereal Fermentation with Lactic Acid Bacteria and Yeasts -- 12. Sourdough and Gluten-Free Products -- 13. Sourdough and Cereal Beverages -- 14. Perspectives.
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    Food Microbiology Laboratory for the Food Science Student : A Practical Approach (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Food—Microbiology. ; Food science. ; Industrial microbiology. ; Food Microbiology. ; Food Science. ; Industrial Microbiology.
    In: Springer Nature eBook
    Description / Table of Contents: This book is designed to give students an understanding of the role of microorganisms in food processing and preservation; the relation of microorganisms to food spoilage, foodborne illness, and intoxication; general food processing and quality control; the role of microorganisms in health promotion; and federal food processing regulations. The listed laboratory exercises are aimed to provide a hands-on-opportunity for the student to practice and observe the principles of food microbiology. Students will be able to familiarize themselves with the techniques used to research, regulate, prevent and control the microorganisms in food and understand the function of beneficial microorganism during food manufacturing process.
    Type of Medium: Online Resource
    Pages: XVIII, 160 p. 62 illus., 60 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031261978
    URL: https://doi.org/10.1007/978-3-031-26197-8
    DOI: 10.1007/978-3-031-26197-8
    Language: English
    Note: Food Microbiology Laboratory Safety and Notebook Record -- Staining Technology and Bright-field Microscope Use -- Enumeration of Bacteria in Broth Suspension by Spread and Pour Plating -- Isolation of Foodborne pathogens on Selective, Differentiate and Enrich Medium by Streak-plating -- Enumeration of Aerobic plate counts, Coliforms and Escherichia coli of Organic Fruit Juice on Petri-film -- Enumeration and identification of Staphylococcus aureus in Chicken Salads -- Enumeration and identification Listeria monocytogenes on ready-to-eat (RTE) frankfurters -- Isolation and identification of Salmonella and Campylobacter spp. on broiler carcasses -- Thermal inactivation of Escherichia coli O157:H7 in Non-intact reconstructed beef patties -- Thermal inactivation of Escherichia coli O157:H7 in mechanically tenderized beef steaks and color measurements -- Evaluate antimicrobial activity of chlorine water on apples and measurement of free chlorine concentrations -- Evaluate cross-contamination of Salmonella on tomatoes in wash water using most probable number (MPN) technique -- Cultivation of Anaerobic Bacteria in Canned Food -- Observation and enumeration of Molds from Spoiled Bread -- DNA Extraction and Purity Determination of Foodborne Pathogens -- Practice of Multiplex PCR to identify bacteria in bacterial solutions -- PCR Identification of Listeria monocytogenes in Deli Meat -- Cheese Making and Characterization -- Wine and Sauerkraut Making and Characterization -- Introduction of oral presentation and job interview preparation -- Appendix- Samples of Food Microbiology Lab Course Syllabus. .
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    Mushrooms with Therapeutic Potentials : Recent Advances in Research and Development (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Pharmacology. ; Therapeutics. ; Internal medicine. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Pharmacology. ; Therapeutics. ; Internal Medicine. ; Fungi. ; Medical Microbiology.
    In: Springer Nature eBook
    Description / Table of Contents: The book presents new and novel perceptions about ailments alleviating the effects of several mushroom species. Also, the book highlights the curative role of medicinal mushrooms on some peripheral and central diseases. Various chapters in the book (primarily reviews) have been dedicated to providing the therapeutic efficacy of mushrooms against respiratory illnesses, gut microbiota, COVID-19, dementia, epilepsy, mental ailments, cancers, cardiovascular, kidney-related diseases, and other common pathologies. Thus, medicinal mushrooms are current and future consumable healthcare products that usually exhibit nourishing properties and possess prophylactic and therapeutic values with minimal adverse effects and contraindications. The book focuses on Sustainable Development Goal (SDG 3) to promote healthy lives and well-being for all. Medical, pharmacy, nursing, and CAM (complementary and alternative medicine) students, practitioners, scholars, researchers, other healthcare professionals, and general readers are this book’s potential audience. The book can be adopted as a textbook for undergraduate and graduate courses so that the therapeutic potential of mushrooms can reach a wider audience. This book strives to create a new resource for the future use of medicinal mushrooms in various disorders. .
    Type of Medium: Online Resource
    Pages: XX, 509 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995507
    URL: https://doi.org/10.1007/978-981-19-9550-7
    DOI: 10.1007/978-981-19-9550-7
    Language: English
    Note: Chapter 1. Mushrooms as Promising Therapeutic Resources: Review and Future Perspectives -- Chapter 2. Medicinal Mushrooms for Respiratory Health -- Chapter 3. Therapeutic and Prophylactic Potential of Medicinal Mushrooms in COVID-19 -- Chapter 4. Influences of Edible Mushrooms on Dynamic and Diversity of Gut Microbiota -- Chapter 5. Mushrooms – From Traditional Remedies to the Modern Therapeutics -- Chapter 6. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health -- Chapter 7. Anticancer Potential of Ganoderma lucidum and İts Relevant Modes of Action -- Chapter 8. Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias -- Chapter 9. Potential of Medicinal Mushrooms in Human Health and Welfare: An Overview -- Chapter 10. Mycotherapeutics Reduce Nephrotoxicity and Renal Diseases -- Chapter 11. Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms -- Chapter 12. Cordyceps militaris (L.): Medicinal aspects in terms of ethnobotanical and pharmacological perspectives -- Chapter 13. Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection -- Chapter 14. Biological Activities of Some Edible Mushrooms -- Chapter 15. Nephroprotective Effects of Four Ganoderma Species -- Chapter 16. Mechanisms Involved in Edible Mushrooms' Health Beneficial Effects -- Chapter 17. Mycotherapy (Medicinal Mushrooms) as a Potential Treatment for Epilepsy -- Chapter 18. Natural vs. Synthetic Psilocybin: The Same or Completely Different? -- Chapter 19. Preventative and Curative Properties of Reishi and Maitake Mushrooms in Cancer.
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    Teaching Science Students to Communicate: A Practical Guide (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Biology. ; Communication in science. ; Teachers—Training of. ; Biological Sciences. ; Science Communication. ; Teaching and Teacher Education.
    In: Springer Nature eBook
    Description / Table of Contents: This highly-readable book addresses how to teach effective communication in science. The first part of the book provides accessible context and theory about communicating science well, and is written by experts. The second part focuses on the practice of teaching communication in science, with ‘nuts and bolts’ lesson plans direct from the pens of practitioners. The book includes over 50 practice chapters, each focusing on one or more short teaching activities to target a specific aspect of communication, such as writing, speaking and listening. Implementing the activities is made easy with class run sheets, tips and tricks for instructors, signposts to related exercises and theory chapters, and further resources. Theory chapters help build instructor confidence and knowledge on the topic of communicating science. The teaching exercises can be used with science students at all levels of education in any discipline and curriculum – the only limitation is a wish to learn to communicate better! Targeted at science faculty members, this book aims to improve and enrich communication teaching within the science curriculum, so that science graduates can communicate better as professionals in their discipline and future workplace.
    Type of Medium: Online Resource
    Pages: X, 559 p. 32 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030916282
    URL: https://doi.org/10.1007/978-3-030-91628-2
    DOI: 10.1007/978-3-030-91628-2
    Language: English
    Note: Part 1. THEORY CHAPTERS -- Chapter 1. The Rhetorical Triangle -- Chapter 2. The social brain and the neuroscience of storytelling -- Chapter 3. Good Science Communication Considers Audience -- Chapter 4. On establishing trust -- Chapter 5. Intentional and unintentional messaging -- Chapter 6. Science graduates & communication in the workplace -- Chapter 7. Models of group decision-making -- Chapter 8. Data Visualisation -- Chapter 9. Misinformation and how to respond -- Chapter 10. Communicating in a space of conflict -- Chapter 11. Critical appraisal of information -- Chapter 12. Communicating risk and uncertainty -- Part 2. PRACTICE Engaging -- Chapter 13. The 5-box talk template for structuring a presentation to any audience -- Chapter 14. Getting students to express an opinion -- Chapter 15. Understanding your target audience through writing their biography -- Chapter 16. Using active learning techniques to engage audiences in oral presentations -- Part 3. PRACTICE Writing -- Chapter 17. Nominalisations - the battle against -me t, -tion, and -ery -- Chapter 18. Learning to write from the way you read -- Chapter 19. How to deconstruct when reading and construct when writing an abstract -- Chapter 20. Using the de-jargonizer and readability scores to help you write clearly -- Part 4. PRACTICE Distilling -- Chapter 21. Statements of Critical Significance (SOCS) for communicating succinctly -- Chapter 22. Infographics -- Chapter 23. Hooks & Headlines -- Chapter 24. Poetry as a device to distil science -- Chapter 25. Put the slides to one side - replacing static slides with a prop -- Part 5. PRACTICE Speaking -- Chapter 26. The think aloud protocol for obtaining feedback on writing -- Chapter 27. Show and speak to design compelling graphs & diagrams -- Chapter 28. Using Sentence Frames and Question Cards to scaffold verbal discourse - Scaffolded practice for engaging in discourse and argumentation in science -- Chapter 29. The power opening - how to grab your audience at the start of your talk -- Chapter 30. Physical presence - how to use your voice and body to be more dynamic speaker -- Chapter 31. Building powerful presentations through framing and a call to action -- Part 6. PRACTICE Listening -- Chapter 32. Mirror-mirror - learning to listen to your audience -- Chapter 33. See it, speak it, draw it and learn to communicate in simple language -- Chapter 34. Understanding the hidden meanings of words using The Word-Association Game -- Chapter 35. Learning to be part of the conversation through blogging and blog commenting -- Part 7. PRACTICE Investigating -- Chapter 36. Using a KLEWS chart to collect and organize information during investigations -- Chapter 37. The RADAR framework for evaluating sources of information -- Chapter 38. Forming a research question -- Part 8. PRACTICE Storytelling -- Chapter 39. Narrative arc, the hero, the villain, and the goal of a story -- Chapter 40. A practical guide to storytelling frameworks -- Chapter 41. The 5 fact story -- Chapter 42. Using the message triangle to distil complex research into a story -- Chapter 43. One-line stories as connections between slides -- Chapter 44. Iconic stories: learn and practice the principles of storytelling using visual cues with and, but, therefore narrative structures -- Chapter 45. Using art and reflection to do a deep dive into science -- Part 9. PRACTICE Communicating with intent -- Chapter 46. So what? Writing an impact statement -- Chapter 47. The Communicate with Intent Framework -- Chapter 48. The values affirmation exercise -- Chapter 49. Identifying personal beliefs and values through group sense making -- Chapter 50. Finding your authentic voice -- Chapter 51. Communicating for inclusion – using powerful images and language to support diversity in science -- Part 10. PRACTICE Genre -- Chapter 52. The Genre Switch Game -- Chapter 53. Creative Podcasting to Develop Content Knowledge and Communication Skills -- Chapter 54. A step-by-step procedure for developing and testing an effective analogy -- Chapter 55. The Conclusion - how to end a scientific report in style -- Part 11. PRACTICE Joining the conversation -- Chapter 56. Interactive writing - speaking with (not at) your audience -- Chapter 57. The "yes, and..." games and exercises to develop active listening and meaningful conversations -- Chapter 58. Active listening - learning through interviewing -- Chapter 59. The research roleplay: understanding the process of research and the role of research stakeholders -- Chapter 60. Embracing communication failures with joy -- Part 12. PRACTICE Arguing and organising -- Chapter 61. How to construct an evidence-based argument -- Chapter 62. Organising your communication using mind maps -- Chapter 63. Writing a project plan -- Part 13. PRACTICE Working -- Chapter 64. Building your personal pitch using a message framework -- Chapter 65. How to be a functional team member -- Chapter 66. Effective notetaking -- Chapter 67. My favourite no - How to Critique the Reasoning of Others -- Chapter 68. Understanding and articulating your value as a science graduate -- Chapter 69. How to conduct elicitation interviews with clients.
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    Agricultural Waste: Environmental Impact, Useful Metabolites and Energy Production (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Agriculture. ; Agricultural biotechnology. ; Subsistence farming. ; Agriculture. ; Agricultural Biotechnology. ; Subsistence Agriculture.
    In: Springer Nature eBook
    Description / Table of Contents: This contributed volume deals with problems associated with huge biomass generated by crop plants and the processing of fruits and food materials. The main focus is to address problems associated with organic residues from agro-industrial processes. This book aims to provide a comprehensive and up-to-date account of various processes involved in the valorization of this huge biomass available from agro-industrial processes and obtaining valuable primary and secondary metabolites which will have an impact on the rural economy. Decrease in forest cover associated with the production of agriculture-based waste resulting in pollutants like smoke by burning of residual crops, waste from breweries, food processing, pruning of bushes and trees, and from industries producing proteins, vegetable oils and fruit juices etc. This book is of interest to teachers, researchers, climate change scientists, agriculture scientists and policymakers. The book brings out the latest reading material for botanists, biotechnologists, environmentalists, biologists, policymakers and NGOs working for environmental protection.
    Type of Medium: Online Resource
    Pages: IX, 589 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811987748
    Series Statement: Sustainable Development and Biodiversity, 31
    URL: https://doi.org/10.1007/978-981-19-8774-8
    DOI: 10.1007/978-981-19-8774-8
    Language: English
    Note: 1 Disposal of Agricultural waste and its effects on Environment, production of useful metabolites and energy: potential and challenges -- 2 Utilizing Agricultural Waste in Production of Biochar for Improving Soil Properties and Increasing Crop Yield through Field Application -- 3 Value-added products from agricultural waste -- 4 Biomaterials derived from agricultural waste – a focus on collagen -- 5 Valorization of Agricultural Lignocellulosic Plant Byproducts Following Biorefinery Approach Towards Circular Bioeconomy -- 6 Bioactive Peptides from Protein-Rich Waste -- 7 Biopolymers in sugarcane vinasse treatment and valorization -- 8 Valorization of Guava fruit by-products -- 9 Valorization of coffee by-products:An overview -- 10 Valorization of tomato fruit processing residues -- 11 Sustainable utilization of tea waste -- 12 Vitis wastes as a source of stilbenes: natural occurrence, factors affecting biosynthesis and valorization in agri-food sector -- 13 Useful bioactive compounds from Olive tree by-products (leaves, branches, fruits) -- 14 Fruit pomaces as valuable by-products of wine and cider industries -- 15 Secondary Metabolites and Antioxidant Activity of the Solid-State Fermentation in Fruit Waste/Bagasse -- 16 Green extraction techniques applied to recover chemical compounds from olive-derived biomasses -- 17 Production and use of hydrolates from the distillation process of aromatic plants -- 18 From agricultural waste to functional food products: An Overview -- 19 Recent advancements in agricultural residues valorisation into bio-products -- 20 Biogas Energy from Animal Waste -- 21 Recent Trends and Future Prospects of Nanotechnology for Agro-wastes Valorization into Biofuels.
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    Integrins in Health and Disease : Key Effectors of Cell-Matrix and Cell-Cell Interactions (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Cell adhesion. ; Cytology. ; Proteins . ; Cell Adhesion. ; Cell Biology. ; Protein Biochemistry.
    In: Springer Nature eBook
    Description / Table of Contents: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: XII, 472 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031237812
    Series Statement: Biology of Extracellular Matrix, 13
    URL: https://doi.org/10.1007/978-3-031-23781-2
    DOI: 10.1007/978-3-031-23781-2
    Language: English
    Note: Part 1: Knockouts and animal models -- Integrins α1β1 and α2β1 – The generalist collagen receptors -- Roles for Integrin α3β1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin 8 and its ligand nephronectin in health and disease -- v integrin-dependent TGF activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- α4 integrins in immune homeostasis and disease -- β2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin αMβ2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens.
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    Genome Editing in Animals : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Genetics. ; Genetics and Genomics.
    In: Springer Nature eBook
    Description / Table of Contents: This second edition provides new and updated protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Editing in Animals: Methods and Protocols, Second Edition aims to be a useful practical guide to researches to help further their study in this field. .
    Type of Medium: Online Resource
    Pages: XI, 399 p. 105 illus., 80 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9781071630167
    Series Statement: Methods in Molecular Biology, 2637
    URL: https://doi.org/10.1007/978-1-0716-3016-7
    DOI: 10.1007/978-1-0716-3016-7
    Language: English
    Note: Construction and Evaluation of Zinc Finger Nucleases -- Updated overview of TALEN construction systems -- CRISPR/Cas9 -- SNPD-CRISPR: Single Nucleotide Polymorphism-Distinguishable Repression or Enhancement of a Target Gene Expression by CRISPR System -- Utilizing large functional and population genomics resources for CRISPR/Cas perturbation experiment design -- Generation of genome-edited mice by cytoplasmic injection of CRISPR-Cas9 RNA -- Gene targeting in mouse embryonic stem cells via CRISPR/Cas9 ribonucleoprotein (RNP) mediated genome editing -- Generation of Knock-in Mouse by Genome Editing -- Introduction of genetic mutations into mice by Base Editor and Target-AID -- Genome editing in mouse and rat by electroporation -- Generation of floxed mice by sequential electroporation -- Efficient detection of flox mice using in vitro Cre recombination -- VCre/VloxP and SCre/SloxP as reliable site-specific recombination systems for genome engineering -- Efficient CRISPR/Cas9-Assisted Knockin of Large DNA Donors by Pronuclear Microinjection During S-phase in Mouse Zygotes -- Genome editing of murine liver hepatocytes by AAV vector-mediated expression of Cas9 in vivo -- Non-Viral Ex Vivo Genome-Editing in Mouse Bona Fide Hematopoietic Stem Cells with CRISPR/Cas9 -- Genome editing of rat -- A simple and efficient method for generating KO rats using in vitro fertilized oocytes -- Editing the Genome of the Golden Hamster (Mesocricetus auratus) -- Gene targeting in rabbits: single-step generation of knockout rabbits by microinjection of CRISPR/Cas9 plasmids -- Genome Editing of Pig -- GEEP method: an optimized electroporation-mediated gene-editing approach for establishment of knockout pig lines -- Genome editing mediated by primordial germ cell in chicken -- CRISPR–Cas9-mediated genome modifications in zebrafish -- Genome Editing of Medaka. -CRISPR-Cas9 based functional analysis in amphibians; Xenopus laevis, Xenopus tropicalis, and Pleurodeles waltl -- Genome Editing of Silkworms -- Improved genome editing in the ascidian Ciona with CRISPR/Cas9 and TALEN -- Genome editing of C. elegans. .
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    The Plant Cytoskeleton : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Plant cells and tissues. ; Botany. ; Plant Cell Biology. ; Plant Science.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume explores the development of technologies and protocols that are currently being used to understand the nature and activities of the plant cytoskeleton. A focus for many of the chapters is on sample preparation, as the quality of plant organ/tissue preparation, from single to multicellular samples, determines the quality of the data. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Plant Cytoskeleton: Methods and Protocols serves as an ideal guide for researchers interested in or starting to be interested in plant cell and molecular biology research.
    Type of Medium: Online Resource
    Pages: XIV, 369 p. 114 illus., 101 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071628676
    Series Statement: Methods in Molecular Biology, 2604
    URL: https://doi.org/10.1007/978-1-0716-2867-6
    DOI: 10.1007/978-1-0716-2867-6
    Language: English
    Note: Quantification of Microtubule Bundling Activity of MAPs Using TIRF Microscopy -- Actin: Static and Dynamic Studies -- 3D Visualization of Microtubules in Epidermal Pavement Cells -- Quantitative Analysis of Microtubule Organization in Leaf Epidermis Pavement Cells -- Single Cell Confinement Methods to Study Plant Cytoskeleton -- Documentation of Microtubule Collisions with Myosin VIII ATM1 Containing Membrane-Associated Structures -- Imaging the Plant Cytoskeleton by High-Pressure Freezing and Electron Tomography -- Confocal Microscopic Assays of Mitotically Active Proteins in an Agrobacterial Infiltration-Based, Cell Division-Enabled Leaf System of Tobacco (Nicotiana benthamiana) -- Assessment of Spindle Shape Control by Spindle Poleward Flux Measurements and FRAP Bulk Analysis -- Expansion Microscopy of Plant Cells (PlantExM) -- Microfluidic Device for High-Resolution Cytoskeleton Imaging and Wash Out Assays in Physcomitrium (Physcomitrella) patens -- Using Spinning Disk Microscopy to Observe the Mitotic and Cytokinetic Apparatus in Physcomitrium patens -- Gaining Insight into Large Gene Families with the Aid of Bioinformatic Tools -- Cell-to-Cell Connectivity Assays for the Analysis of Cytoskeletal and Other Regulators of Plasmodesmata -- Studying Nuclear Dynamics in Response to Actin Disruption In Planta -- Cytoskeleton Remodelling in Arabidopsis Stigmatic Cells Following Pollination -- Investigation of ROP GTPase Activity and Cytoskeleton Dynamics during Tip Growth in Root Hairs and Pollen Tubes -- Functional Analysis of Phospholipid Signaling and Actin Dynamics: The Use of Apical Growing Tobacco Pollen Tubes in a Case Study -- Microtubule Reorganization during ABA-Induced Stomatal Closure in Arabidopsis -- Imaging of Cortical Microtubules in Plants under Salt Stress -- Analysis of Actin Array Rearrangement during the Plant Response to Bacterial Stimuli -- Live-Cell Imaging of Cytoskeletal Responses and Trafficking during Fungal Elicitation -- Visualization and Quantification of the Dynamics of Actin Filaments in Arabidopsis Pollen Tubes -- Non-Invasive Long-Term Imaging of the Cytoskeleton in Arabidopsis Seedlings -- Visualization of Cytoskeleton Organization and Dynamics in Elongating Cotton Fibers by Live-Cell Imaging -- Methods to Visualize and Quantify Cortical Microtubule Arrays in Arabidopsis Conical Cells -- Studying the Organization of the Actin Cytoskeleton in the Multicellular Trichomes of Tomato -- Light Microscopy Technologies and the Plant Cytoskeleton -- Investigating Plant Protein-Protein Interactions Using FRET-FLIM with a Focus on the Actin Cytoskeleton.
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    Dicotyledons: Rosids (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Botany. ; Plant anatomy. ; Plants—Development. ; Plant Science. ; Plant Anatomy and Morphology. ; Plant Development.
    In: Springer Nature eReference
    Description / Table of Contents: The succulent species of the families of subclass Rosidae are presented by alphabet of families, genera, and species, with comprehensive listings of synonyms added at all levels. Detailed descriptions are given for all accepted taxa, together with data on the distribution and typification, and references to the most important literature. Where necessary, information on ecology, ethnobotany, history, etc. is added, and in many places, proposed relationships are critically discussed. The volume covers the succulents from the families Anacardiacae, Begoniaceae, Bixaceae, Brassicaceae, Burseraceae, Capparaceae, Caricaceae, Clusiaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Francoaceae, Geraniaceae, Malvaceae, Melastomataceae, Meliaceae, Moraceae, Moringaceae, Oxalidaceae, Passifloraceae, Sapindaceae, Tropaeolaceae, Urticaceae, Vitaceae and Zygophyllaceae.
    Type of Medium: Online Resource
    Pages: 526 illus., 507 illus. in color. eReference. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783030934927
    Series Statement: Illustrated Handbook of Succulent Plants
    URL: https://doi.org/10.1007/978-3-030-93492-7
    DOI: 10.1007/978-3-030-93492-7
    Language: English
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    Fisheries and Aquaculture of the Temperate Himalayas (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Grassland ecology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Grassland Ecology.
    In: Springer Nature eBook
    Description / Table of Contents: This book covers all aspects of fisheries and aquaculture of the temperate Himalayas, including fisheries resources, fish biodiversity, aquaculture status, prospects, and potential. It also includes mapping of resources, health and disease management of cultured species, feed and nutritional aspects of the cultured fish species, ornamental fisheries aspects, etc. In addition, it elucidates the recent advances in biotechnological interventions for enhancing fisheries and aquaculture productivity in the region. Essential information on the application of Geo Information System (GIS) for resource mapping, the scope of adopting re-circulatory aquaculture system for productivity enhancement, and trout culture in the Himalayan waters are provided in the book. A detailed account of recreational fisheries and fish-based ecotourism in the temperate Himalayas for generating livelihood has been provided. The impact of climate change on the fisheries of the Himalayas has been dealt with separately. The book also covers the conservation and rehabilitation aspects of endangered species of the region. This book will become a ready reference for the scientists, teachers, researchers, students, policymakers, and other stakeholders for managing fishery resources in the temperate Himalayas.
    Type of Medium: Online Resource
    Pages: XVI, 488 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811983030
    URL: https://doi.org/10.1007/978-981-19-8303-0
    DOI: 10.1007/978-981-19-8303-0
    Language: English
    Note: Chapter 1. Fish and fisheries of the temperate Himalayas: An overview and way-forward -- Chapter 2. Fishery resources and ichthyofaunal diversity in the temperate Himalayas -- Chapter 3. Mapping of the Himalayan surface waters using remote sensing and geographic information system tools: An overview of single band-based techniques -- Chapter 4. Fisheries development in open water resources of the temperate Himalaya -- Chapter 5. Diversity and threat to coldwater fishes of river Torsa at the Terai region of West Bengal, India -- Chapter 6. The endangered mighty mahseer (Tor putitora) in the Himalayan waters -- Chapter 7. Aquaculture practices in the temperate Himalayan region -- Chapter 8. Status and prospects of rainbow trout farming in Himalayan waters -- Chapter 9. Fisheries and aquaculture of snow trouts in the Trans-Himalayan region -- Chapter 10. Ornamental Fisheries in Hindu Kush Himalayan Region -- Chapter 11. Recirculating aquaculture system for intensive fish farming in Indian Himalayan region: An overview -- Chapter 12. Coldwater fish nutrition in the Indian Himalayas -- Chapter 13. Molecular characterization and population structure of the important Himalayan fish species -- Chapter 14. Prospects and challenges of molecular interventions for enhancing aquaculture production in the temperate Himalayas -- Chapter 15. An overview of coldwater fish diseases and their control measuresChapter 16. Oomycetes, fungal-like menace in coldwater aquaculture -- Chapter 17. Antimicrobial peptides: An alternative to antibiotics for environment-friendly hill aquaculture -- Chapter 18. Advances in detection techniques for fungus-like organisms of aquaculture importance -- Chapter 19. Nutritional quality and human health benefits of important coldwater fishes of the Indian Himalayas -- Chapter 20. En-route towards aquaponics in coldwater: Identifying the gaps in principles and system design -- Chapter 21. Impact of climate change in temperate fisheries of the Himalayas and possible adaptation approaches -- Chapter 22. Livelihood opportunities with recreational fisheries and ecotourism -- Chapter 23. Design and operational principle of re-circulatory aquaponic system in the Himalayas: Prospects and challenges -- Chapter 24. Farm design and layout for aquaculture operations in the temperate Himalayas -- Chapter 25. Hydroelectric projects: An inevitable challenge in fisheries of the temperate Himalaya.
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    Metabolism of Alimentary Compounds by the Intestinal Microbiota and Health (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Nutrition   . ; Medical microbiology. ; Human physiology. ; Medicine, Preventive. ; Health promotion. ; Nutrition. ; Medical Microbiology. ; Human Physiology. ; Health Promotion and Disease Prevention.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues. Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented. Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.
    Type of Medium: Online Resource
    Pages: XIII, 254 p. 57 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263224
    URL: https://doi.org/10.1007/978-3-031-26322-4
    DOI: 10.1007/978-3-031-26322-4
    Language: English
    Note: Chapter 1. Physiological and Metabolic Functions of the Intestinal Epithelium: From the Small to the Large Intestine -- Chapter 2. Intestine Offers Board and Lodging for Intestinal Microbes on a Short- or Long-Term Stay -- Chapter 3. Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine -- Chapter 4. Alimentation, Bacterial Metabolites, and Host Intestinal Epithelium -- Chapter 5. Modification of the Bacterial Metabolites by the Host after Absorption, and Consequences for the Peripheral Tissues’ Metabolism, Physiology, and Pathophysiology -- Chapter 6. Lessons to Be Learned from Clinical and Experimental Research on the Intestinal Microbiota Metabolic Activity for Health Benefit and Perspectives.
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    Xenobiotics in Aquatic Animals : Reproductive and Developmental Impacts (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Freshwater ecology. ; Marine ecology. ; Reproduction. ; Physiology. ; Pollution. ; Freshwater and Marine Ecology. ; Reproductive Physiology. ; Pollution.
    In: Springer Nature eBook
    Description / Table of Contents: This book summarizes the latest understanding of the impact of xenobiotics on the developmental and reproductive processes of aquatic animals, particularly nektonic forms, which comprise an important group of aquatic ecosystems. Aquaculture is quickly becoming the largest contributor of fish protein for human consumption. As the aquaculture business expands, farmed fish will be exposed to more environmental toxins, necessitating the use of chemical therapeutic drugs for fish. This book brings together experts on the regulation of environmental toxins and food chemicals from around the world, as well as researchers looking into the metabolism and disposal of foreign chemicals (xenobiotics) in fish species. The impact of xenobiotics on reproductive and developmental biology of all living forms has become of prime importance at the current time. As the effect of these xenobiotics on aquatic animals is an emerging area for research and development, several groups across the world are working on these aspects, targeting different groups of fishes in both marine and freshwater ecosystems. This collective work highlights several key and updated recent aspects of different types of xenobiotics entering aquatic ecosystems, impacts of these agents on reproductive physiology, developmental biology, breeding biology, hormonal imbalance, aquatic ecology, and pollution on the aquatic ecosystem. The unique aggregation of different types of stressors to aquatic animals under a single volume will be a useful reference for readers, including scientists, teachers, students, researchers and policymakers and those involved in aquaculture and environment conservation.
    Type of Medium: Online Resource
    Pages: XXIX, 427 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819912148
    URL: https://doi.org/10.1007/978-981-99-1214-8
    DOI: 10.1007/978-981-99-1214-8
    Language: English
    Note: 1. Pesticide and xenobiotic metabolism in aquatic organisms -- 2. Endocrine disrupting activity of xenobiotics in aquatic animals -- 3. Water contamination through xenobiotics and their toxic effects on aquatic animals -- 4. Cypermethrin induced reproductive toxicity in zebrafish: biochemical and molecular perspective -- 5. Impact of Pesticides Application on Aquatic Environments And Biodiversity -- 6. Impact of microplastics on reproductive and physiological aspects of aquatic inhabitants -- 7. The Impact of Xenobiotics in Development & Reproduction of fresh water Fishes -- 8. Mixtures and Reproduction in Aquatic Organisms – benefits and challenges -- 9. Phytoestrogens as Endocrine-Disrupting Agents In Aquaculture -- 10. A Proteomic Approach to Studying the Effects of Xenobiotics on Aquatic Living Organisms -- 11. Role of Cytochrome P450 in xenobiotic metabolism in fishes -- 12. Pharmacokinetic-Pharmacodynamic modelling of Xenobiotics: Fate and effect in Aquatic Animals -- 13. Occurrence of xenoestrogen alkylphenols (Octylphenols and Nonylphenol), and its impact on the aquatic ecosystem -- 14. Xenobiotics' effect on fish reproduction and development -- 15. Scientometric analysis of ecotoxicological investigations of xenobiotics in aquatic animals -- 16. Toxic effects of nanomaterials on aquatic animals and their future prospective -- 17. Microplastic Contamination in Aquatic organisms: An Ecotoxicological perspective -- 18. Effect of xenobiotics and their degradation in aquatic life -- 19. Transcriptome analysis of aquatic species exposed to endocrine disruptors -- 20. Fundamentals of genotoxicity and antiparasitic drugs associated with genotoxicity in fish -- 21. Endocrine disrupting compounds (EDCs) as emerging aquatic contaminants: Emphasis on Reproduction and Development.
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    Emerging Sustainable Aquaculture Innovations in Africa (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Zoology. ; Animal culture. ; Anatomy, Comparative. ; Sustainability. ; Zoology. ; Animal Science. ; Animal Anatomy. ; Sustainability.
    In: Springer Nature eBook
    Description / Table of Contents: This edited book presents the emerging sustainable innovations in all areas of aquaculture in Africa with a view to create an opportunity whereby scientific outputs and recommendations can be endorsed for improved aquaculture outputs towards poverty alleviation and food security on the continent. Food insecurity and poverty are some of the challenges faced on the African continent. These challenges are further exacerbated by the growing human population and the impacts of climate change. Today, aquaculture has become one of the fastest food producing sectors in the world, with the potential to contribute significantly to food security and poverty alleviation in developing countries. In Africa, aquaculture is at an infant stage, however, many African countries have recognized the potential roles of aquaculture in food security, poverty alleviation and conservation of aquatic resources through their commitment to achieve the United Nation Sustainable Development Goals. The book reviews and synthesize research work from these thematic areas across Africa and provide a unique perspective on the emerging aquaculture innovations and illustrate how aquaculture practices could be feasible and cost effective while promoting social and environmental sustainability. The book also draws from global discussions on sustainable aquaculture practices and provides recommendations on what is feasible for Africa. This book is a great tool for the university students, scholars, aquaculture farmers, investors, and policymakers to understand the scientific based sustainable aquaculture innovations from an African perspective. This book is focused on SDG 2 and SDG 14.. .
    Type of Medium: Online Resource
    Pages: XIV, 552 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811974519
    Series Statement: Sustainable Agriculture and Food Security,
    URL: https://doi.org/10.1007/978-981-19-7451-9
    DOI: 10.1007/978-981-19-7451-9
    Language: English
    Note: 1. Fish nutrition: an African aquaculture perspective -- 2. Feed restriction as a feed management strategy in tilapia and catfish culture: An African perspective -- 3. Black soldier fly (Hermetia illucens) larvae meal as a sustainable protein source for fish feed production in Kenya -- 4. Waste to feed: an emerging technology to improve aquaculture in Africa -- 5. Prebiotics as functional ingredients in aquafeed: Trends and prospects in African aquaculture -- 6. The potential benefits of Aloe vera products in aquafeed: current knowledge and prospects -- 7. Use of plant extracts to control reproduction in tilapia production systems: An emerging eco-friendly innovation -- 8. Pawpaw (Carica papaya) extracts as potential growth promoters and sex reversal agents in aquaculture -- 9. Microbial-based systems and single-cell ingredients: exploring their role in sustainable aquaculture production -- 10. Ferulic acid as feed additives in aquaculture: A review on growth, immune response, and antioxidant status of finfish -- 11. The importance and utilisation of oil palm as a fish oil replacement in aquaculture -- 12. A dynamic study of Jatropha curcas on growth and haematological indices in finfish.-13. Applications of aquatic plants in the remediation of aquaculture wastewater: An opportunity for African aquaculture -- 14. African Aquaculture: Enhancement of water quality for sustainable freshwater finfish culture -- 15. Nutrient budget of cage fish culture in a lacustrine environment: Towards model development for the sustainable development of Nile tilapia (Oreochromis niloticus) culture -- 16. Aquaponics as a sustainable food production system with promising development perspectives in Morocco -- 17. Enhancing Food Production employing Integrated Aquaculture in Namibia. Fish Integration with Poultry -- 18. Fishing for answers: should Afrotropical farmers use cages or ponds for grow-out of Nile tilapia?- 19. Aquaculture development perspectives in Sierra Leone. The challenges of critical inputs and political will -- 20. The Namibian mariculture: productivity, challenges, and opportunities -- 21. Climate SMART Best Practices in Aquaculture and Fisheries with Specific Emphasis on Sierra Leone -- 22. The potential of small-scale freshwater aquaculture for household nutritional security and malnutrition alleviation in Namibia -- 23. The Southern mullet (Chelon richardsonii) as a potential candidate species for aquaculture in the Southern African region -- 24. Some significant parasites in aquaculture and their potential impact on the development of aquaculture in Africa -- 25. Interactions between pre-harvest, post-harvest handling and welfare of fish for sustainability in the Aquaculture Sector -- 26. Alternative fish anaesthetics: Perspective on their application in African aquaculture and fisheries research.
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    Fungi and Fungal Products in Human Welfare and Biotechnology (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Microbiology. ; Fungi. ; Mycology. ; Biotechnology. ; Microbiology. ; Fungi. ; Biotechnology.
    In: Springer Nature eBook
    Description / Table of Contents: This book presents various biotechnological applications of the fungal systems in pharmaceuticals, nutraceuticals, textile industry, bioremediation, biofuel, and the production of biomolecules. It discusses the important role of fungal secondary metabolites in human welfare and nutrition. It explores fungi as the vital sources of novel substances with antidiabetic, antibiotic as well as prebiotic properties. The book further describes the natural and unique ability of fungi to biodegrade macro- and microplastics by using them as a source of carbon and energy. Notably, it presents the properties and applications of bioactive fungal polysaccharides and discusses the latest developments in utilizing these biopolymers in human nutrition. In addition, the book examines the production of biodegradable and sustainable natural colorants from fungal sources. This book is a valuable source for mycologists, biotechnologists, and microbiologists for understanding the important role of fungi in biotechnology.
    Type of Medium: Online Resource
    Pages: XVI, 678 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811988530
    URL: https://doi.org/10.1007/978-981-19-8853-0
    DOI: 10.1007/978-981-19-8853-0
    Language: English
    Note: Part I. Plant Growth Promotion and Sustainability -- Chapter 1. Arbuscular mycorrhizal fungi: role as biofertilizers, technology development and economics -- Chapter 2. Role of ectomycorrhizal fungi in human welfare -- Chapter 3. Fungal ministrations in soil detoxification, building and health restoration -- Chapter 4. Emerging mucormycosis: problems and treatments -- Chapter 5. Microplastic pollution: sources, environmental hazards and mycoremediation as a sustainable solution -- Part II. Fungal metabolic Products -- Chapter 6. A bird’s eye view of fungal peptides -- Chapter 7. Cultivation, bioactive metabolites and application of caterpillar mushroom Cordyceps militaris: Current status, issues and perspectives -- Chapter 8. Lactic acid production from fungal machineries and mechanism of PLA synthesis: Application of AI based technology for improved productivity -- Chapter 9. Discovery of bioactive metabolites from the genus Arthrinium -- Chapter Chapter 10. Wide range applications of fungal pigments in textile dyeing -- Part III. Fungi in Food Biotechnology -- Chapter Chapter 11. The potential of mushrooms in developing healthy food and biotech products -- Chapter 12. Fungal enzyme-based nutraceutical oligosaccharides -- Chapter 13. Applications of fungi for alternative protein -- Part IV. Fungal Enzymes and Other Biotech Products -- Chapter 14. Fungal enzymes in the production of biofuels -- Chapter 15. Fungal pectinases: Diversity and multifarious applications -- Chapter 16. Applicability of fungal xylanases in food biotechnology -- Chapter 17. Fungal therapeutic enzymes: Utility in the treatment of human ailments -- Chapter 18. Heterologous gene expression in Pichia pastoris: Success stories and commercial ventures -- Chapter 19. Agro-industrial residues: an ecofriendly and inexpensive substrate for fungi in the development of white biotechnology -- Chapter 20. Design strategies for mycelium-based composites -- Chapter 21. Development of building insulation material from fr fungal mycelium.
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    Protein-based Therapeutics (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Therapeutics. ; Diseases. ; Proteins. ; Therapeutics. ; Diseases. ; Proteins.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic biomarkers. Further, it discusses challenges associated with the clinical implications of therapeutic proteins, including safety, immunogenicity, protein stability, degradation, and efficacy. It illustrates the development of biosimilar antibodies, optimization strategies for producing biobetter antibodies, and presents fundamental concepts about biosuperior therapeutics. Lastly, it includes a discussion about protein-based vaccines against bacterial and viral infections.
    Type of Medium: Online Resource
    Pages: IX, 384 p. 76 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811982491
    URL: https://doi.org/10.1007/978-981-19-8249-1
    DOI: 10.1007/978-981-19-8249-1
    Language: English
    Note: Chapter 1_Introduction to Protein Therapeutics. -- Chapter 2_Clinical Applications of Protein-based Therapeutics Against Various Diseases. -- Chapter 3_Protein Engineering Methods for the Design of Protein Therapeutics -- Chapter 4_Recombinant Production of Therapeutic Proteins -- Chapter 5_Antibodies as Protein Therapeutics -- Chapter 6_Streptokinase: The Success Story of a Therapeutic Protein -- Chapter 7_Strategies for Formulation and Systemic Delivery of Therapeutic Proteins -- Chapter 8_Approved Protein Therapeutics and Their Biochemical Targets -- Chapter 9_Pharmacogenetic Biomarkers of Protein Therapeutics -- Chapter 10_Immunogenicity of Therapeutic Proteins -- Chapter 11_Efficacy and Safety Issues of Therapeutic Proteins -- Chapter 12_Emerging Trends, Challenges, and Opportunities in Protein Therapeutics -- Chapter 13_Biosimilar, Biobetter & Biosuperior Therapeutic Proteins -- Chapter 14_Therapeutic Protein-based Vaccines.
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    Stem Cell-Based Neural Model Systems for Brain Disorders (2023)
    New York, NY : Springer US
    Details
    Subject(s): Nervous system—Diseases. ; Stem cells. ; Biological models. ; Neurological Disorders. ; Stem Cell Biology. ; Biological Models.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume presents validated and well-adapted procedures involving humanized and/or stem cell-based neural model systems that have proven helpful in better understanding the essential brain functions involved in the pathogenesis of brain disorders. The book explores the generation of multiple neural cell types in 2D and 3D as well as cutting-edge techniques to assay neural function. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell-Based Neural Model Systems for Brain Disorders serves as an essential resource for researchers and students in neuroscience, stem cell biology, and related fields.
    Type of Medium: Online Resource
    Pages: XIII, 292 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071632871
    Series Statement: Methods in Molecular Biology, 2683
    URL: https://doi.org/10.1007/978-1-0716-3287-1
    DOI: 10.1007/978-1-0716-3287-1
    Language: English
    Note: Generation of Cerebral Cortical Neurons from Human Pluripotent Stem Cells in 3D Culture -- Generation of Homogeneous Populations of Cortical Interneurons from Human Pluripotent Stem Cells -- Generation and Co-Culture of Cortical Glutamatergic and GABAergic Induced Neuronal Cells -- Transcription Factor-Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells -- Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors -- The Generation and Functional Characterization of Human Microglia-Like Cells Derived from iPS and Embryonic Stem Cells -- Modeling Cellular Crosstalk of Neuroinflammation Axis by Tri-Cultures of iPSC-Derived Human Microglia, Astrocytes, and Neurons -- Generation of Oligodendrocytes from Human Pluripotent and Embryonic Stem Cells -- Characterizing the Neuron-Glial Interactions by the Co-Cultures of Human iPSC-Derived Oligodendroglia and Neurons -- Defined Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial-Like Cells for Modeling the Blood-Brain Barrier -- Modeling the Blood-Brain Barrier Using Human Induced Pluripotent Stem Cells -- A Three-Dimensional Primary Cortical Culture System Compatible with Transgenic Disease Models, Virally-Mediated Fluorescence, and Live Microscopy -- Method to Generate Dorsal Forebrain Brain Organoids from Human Pluripotent Stem Cells -- A 3D Bioengineered Neural Tissue Model Generated from Human iPSC-Derived Neural Precursor Cells -- FACS-Based Sequencing Approach to Evaluate Cell Type to Genotype Associations Using Cerebral Organoids -- Dynamic Measurement of Endosome-Lysosome Fusion in Neurons Using High-Content Imaging -- Live-Imaging Detection of Multivesicular Body-Plasma Membrane Fusion and Exosome Release in Cultured Primary Neurons -- Assays of Monitoring and Measuring Autophagic Flux for iPSC-Derived Human Neurons and Other Brain Cell Types -- Measuring Neuronal Network Activity Using Human Induced Neuronal Cells -- A Simple Ca2+-Imaging Approach of Network-Activity Analyses for Human Neurons -- Whole Cell Patch Clamp Electrophysiology in Human Neuronal Cells -- Assaying Chemical Long-Term Potentiation in Human iPSC-Derived Neuronal Networks.
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    Microfluidic Systems for Cancer Diagnosis (2023)
    New York, NY : Springer US
    Details
    Subject(s): Cancer. ; Microfluidics. ; Cancer Biology. ; Microfluidics.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume explores recent developments in microfluidics technologies for cancer diagnosis and monitoring. The book is divided into two sections that delve into techniques for liquid biopsy for cancer diagnosis and platforms for precision oncology or personalized medicine in order to create effective patient avatars for testing anti-cancer drugs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microfluidic Systems for Cancer Diagnosis serves as an ideal guide that will be helpful to either replicate the construction of microfluidic devices specifically developed for cancer diagnosis or to catalyze development of new and better cancer diagnostic devices.
    Type of Medium: Online Resource
    Pages: XIII, 324 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071632710
    Series Statement: Methods in Molecular Biology, 2679
    URL: https://doi.org/10.1007/978-1-0716-3271-0
    DOI: 10.1007/978-1-0716-3271-0
    Language: English
    Note: Lateral Filter Array Microfluidic Devices for Detecting Circulating Tumor Cells -- Circulating Tumor Cell Cluster Sorting by Size and Asymmetry -- Digital Microfluidics with an On-Chip Drug Dispenser for Single or Combinational Drug Screening -- Affinity-Based Microfluidics Combined with Atomic Force Microscopy for Isolation and Nanomechanical Characterization of Circulating Tumor Cells -- Capture and Selective Release of Viable Circulating Tumor Cells -- Single-Response Electronic Tongue and Machine Learning Enable the Multidetermination of Extracellular Vesicle Biomarkers for Cancer Diagnostics without Recognition Elements -- Functional Interrogation of Ca2+ Signals in Human Cancer Cells In Vitro and Ex Vivo by Fluorescent Microscopy and Molecular Tools -- Microfluidic Protocols for the Assessment of Anti-Cancer Therapies in 3D Tumor-Stromal Co-Cultures -- A Microfluidic Approach for Enrichment and Single-Cell Characterization of Circulating Tumor Cells from Peripheral Blood -- Rapid On-Site Evaluation (ROSE): A Microfluidic Approach -- Microfluidic Acoustic Method for High Yield Extraction of Cell-Free DNA in Low-Volume Plasma Samples -- Isolation of Extracellular Vesicles by a Microfluidic Platform to Diagnose and Monitor Pancreatic Cancer -- High-Throughput Separation and Enrichment of Rare Malignant Tumor Cells from Large-Volume Effusions by Inertial Microfluidics -- SAIF: Label-Free Separation of Circulating Tumor Cells Using a Self-Amplified Inertial Focusing Microfluidic Chip -- Patient-Specific Microfluidic Cancer Spheroid Cultures for Testing Cancer Therapies -- Isolation of Cancer Cells from Liquid Biopsies Using 3D-Printed Affinity Devices -- A Microfluidic SERS Assay to Characterize the Phenotypic Heterogeneity in Cancer-Derived Small Extracellular Vesicles -- Cluster-Wells: A Technology for Routine and Rapid Isolation of Extremely Rare Circulating Tumor Cells Clusters from Unprocessed Whole Blood -- Secretion Function Analysis of Ex Vivo Immune Cells in an Integrated Microfluidic Device -- Dynamic Tumor Perfusion and Real-Time Monitoring in a Multiplexed 3D Printed Microdevice -- Capture and Release of Cancer Cells through Smart Bioelectronics -- Fabrication of Multilayer Microfluidic Arrays for Passive, Efficient DNA Trapping and Profiling.
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    Intestinal Differentiated Cells : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Cytology. ; Cell Biology.
    In: Springer Nature eBook
    Description / Table of Contents: This volume details the most up-to-date methods of intestinal differentiation program. Chapters guide readers through techniques to characterize intestinal differentiated cell, RNAseq, single-cell RNAseq transcriptional profiling methods, isolation of intestinal crypts, and methods for studying intestinal differentiated cancer cells. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Intestinal Differentiated Cells: Methods and Protocols aims to be comprehensive guide for researchers.
    Type of Medium: Online Resource
    Pages: XII, 275 p. 84 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071630761
    Series Statement: Methods in Molecular Biology, 2650
    URL: https://doi.org/10.1007/978-1-0716-3076-1
    DOI: 10.1007/978-1-0716-3076-1
    Language: English
    Note: Differentiated epithelial cells of the gut -- Identification of differentiated intestinal epithelial cells using immunostaining and fluorescence microscopy -- Novel approach to measure Trans Epithelial Electrical Resistance in intestinal cells -- In vivo model for isolating epithelial cells of the anorectal transition zone -- In vitro and in vivo assays for testing retinoids effect on intestinal progenitors’ lineage commitments -- TORNADO-seq: a protocol for high-throughput targeted RNA-seq based drug screening in organoids -- Epigenetic and transcriptional dynamics of Notch program in intestinal differentiation -- Defining anorectal transition zone heterogeneity using single-Cell RNA sequencing -- Directed differentiation of murine and human small intestinal organoids towards all mature lineages -- Modeling Notch activity and lineage decisions using intestinal organoids -- Generation of fetal Intestinal organoids and their maturation into adult intestinal cells -- Visualization of differentiated cells in 3D- and 2D-intestinal organoid cultures -- In-vitro culture and histological evaluation of 3D organotypic cultures -- Fluorescence intensity and fluorescence lifetime imaging (FLIM) microscopies of cell differentiation in the small intestinal organoids using cholera toxin -- In vitro morphogenesis and differentiation of human intestinal epithelium in a gut-on-a-chip -- Co-culturing human intestinal enteroid monolayers with innate immune cells -- Measuring cell differentiation in colorectal cancer -- Intestinal cell differentiation and phenotype in 2D and 3D cell culture models -- Confocal laser scanning imaging of cell junctions in human colon cancer cells -- Automated quantitative analysis of shape features in human epithelial monolayers and spheroids generated from colorectal cancer cells.
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    Protein Cages : Design, Structure, and Applications (2023)
    New York, NY : Springer US
    Details
    Subject(s): Proteins. ; Proteins.
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides the latest methods for synthesis, structural analysis, and elucidation of the mechanism. Chapters guide readers through methods on protein cages for nanotechnology, analyze designed protein cages, determine the structures, and even perform theoretical analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Cages: Methods and Protocols aims to be a useful and practical guide. This volume provides the latest methods for synthesis, structural analysis, and elucidation of the mechanism. e to new researchers and experts looking to expand their knowledge. .
    Type of Medium: Online Resource
    Pages: XII, 422 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071632222
    Series Statement: Methods in Molecular Biology, 2671
    URL: https://doi.org/10.1007/978-1-0716-3222-2
    DOI: 10.1007/978-1-0716-3222-2
    Language: English
    Note: Coiled-coil Protein Origami: Design, Isolation and Characterization -- Artificial Protein Cages Assembled Via Gold Coordination -- Reassembly Design of Ferritin Cages -- Protein Cages and Nanostructures Constructed from Protein Nanobuilding Blocks -- Preparation of Cage-like Micellar Assemblies of Engineered Hemoproteins -- Fabrication of Protein Macromolecular Frameworks (PMFs) and Their Application in Catalytic Materials -- Iron Accumulation in Ferritin -- A Generalized Method for Metal Fixation in Horse Spleen L-Ferritin Cage -- Dual Modification of Artificial Protein Cage -- Modification and Production of Encapsulin -- Cryo-electron Microscopy of Protein Cages -- Time-resolved Small-angle X-Ray Scattering of Protein Cage Assembly -- Protein Cage-Stabilized Emulsions: Formulation and Characterization -- A Method to Investigate the Mechanism of Charge Transport across Bio-Molecular Junctions with Ferritin -- Potato Virus X Inactivation and Characterization -- Molecular Dynamics Simulation of Protein Cages -- Coarse-grained Models for Vault Normal Model Analysis -- Evaluating Anti-Tumor Immune Responses of Protein Nanoparticle-Based Cancer Vaccines -- Construction Protocol of Drug-Protein Cage Complexes for Drug Delivery System -- Protein Cage Relaxivity Measurement for Magnetic Resonance Imaging Contrast Agents -- Crystalline Biohybrid Materials Based on Protein Cages -- Production and Purification of Virus-like Particles by Transient Expression in Plants -- Laboratory Scale Production of Complex Proteins Using Charge Complimentary Nanoenvironments.
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    Diabetic Retinopathy : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Medicine—Research. ; Biology—Research. ; Endocrine glands. ; Ophthalmology. ; Biomedical Research. ; Endocrine System. ; Ophthalmology.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume provides various cellular and experimental animal models and research methodologies to understand the complex interrelated pathophysiological mechanisms triggered by hyperglycemia that underlie the development of diabetic retinopathy. The book covers methods for understanding the pathogenesis of diabetic retinopathy, detection and screening of biomarkers in diabetic retinopathy, as well as novel technologies for diabetic retinopathy management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Diabetic Retinopathy: Methods and Protocols serves as an invaluable resource for scientists and clinicians who are interested in the area of ophthalmology research.
    Type of Medium: Online Resource
    Pages: XII, 220 p. 46 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071632550
    Series Statement: Methods in Molecular Biology, 2678
    URL: https://doi.org/10.1007/978-1-0716-3255-0
    DOI: 10.1007/978-1-0716-3255-0
    Language: English
    Note: Induction of Type 2 Diabetes in Mice to Understand Vascular Changes that Drive Diabetic Retinopathy -- Akimba Proliferative Diabetic Retinopathy Model: Understanding Molecular Mechanism and Drug Screening for the Progression of Diabetic Retinopathy -- Oxygen-Induced Retinopathy in the Rat: An Animal Model to Study the Proliferative Retinal Vascular Pathology -- Retinal Assessment Using In Vivo Electroretinography and Optical Coherence Tomography in Rodent Models of Diabetes -- A Guide to Genome Wide Association Study Design for Diabetic Retinopathy -- Single Cell RNA Sequencing (scRNA-Seq) Data Analysis of Retinal Homeostasis and Degeneration of Microglia -- Bioinformatics Tools for Bulk Gene Expression Deconvolution in Diabetic Retinopathy -- MicroRNA Profiling from Tears as a Potential Non-Invasive Method for Early Detection of Diabetes Retinopathy -- Proximity Extension Assay (PEA) Platform to Detect Vitreous Biomarkers of Diabetic Retinopathy -- Methods for Analyzing the Gut Microbiota in Diabetic Retinopathy -- Mass Spectrometry-Based Vitreous Proteomics: Validated Methods and Analysis Pipeline -- Methods for Ex Vivo AAV Transduction in Rodent and Human Retinal Explants -- Methods for RPE Sheet Construction Using iPS-CM in Conjunction with Natural Scaffold of Corneal Lenticule Derived from SMILE -- Chromatin Immunoprecipitation Assay in Mouse Retinal Tissue -- Frozen Block Tissue Staining for Eye Structure of Zebrafish Embryo -- Investigating the Function of MicroRNAs in Human Retinal Microvascular Endothelial Cells of Diabetic Retinopathy -- Genome Editing Inhibits Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy.
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    Advances in Pharmacokinetics and Pharmacodynamics (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Drug delivery systems. ; Drugs—Design. ; Pharmaceutical chemistry. ; Metabolism. ; Pharmacology. ; Clinical biochemistry. ; Drug Delivery. ; Structure-Based Drug Design. ; Pharmaceutics. ; Metabolism. ; Pharmacology. ; Medical Biochemistry.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
    Type of Medium: Online Resource
    Pages: XI, 204 p. 37 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031295416
    Series Statement: AAPS Introductions in the Pharmaceutical Sciences, 9
    URL: https://doi.org/10.1007/978-3-031-29541-6
    DOI: 10.1007/978-3-031-29541-6
    Language: English
    Note: Pharmacokinetics -- Chapter 1: Current status in PBPK modeling -- Chapter 2: Physiologically based biopharmaceutics modeling (PBBM) Application on Food Effect Assessment -- Chapter 3: Physiologically based finite time pharmacokinetic (PBFTPK) models: Inception and development -- Chapter 4: Physiologically based finite time pharmacokinetic (PBFTPK) models: Applications -- Pharmacodynamics -- Chapter 5: Pharmacokinetic – Pharmacodynamic Modelling and Simulation in Clinical Practice and Studies -- Chapter 6: On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body -- Chapter 7: Impact of Clinical Pharmacology on the Modernization of Drug Development and Regulation.
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    Cell Biology and Translational Medicine, Volume 19 : Perspectives in Diverse Human Diseases and Their Therapeutic Options (2023)
    Cham : Springer Nature Switzerland
    Details
    Subject(s): Cytology. ; Virology. ; Neurosciences. ; Cancer. ; Stem cells. ; Sports medicine. ; Cell Biology. ; Virology. ; Neuroscience. ; Cancer Biology. ; Stem Cell Biology. ; Sports Medicine.
    In: Springer Nature eBook
    Description / Table of Contents: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 19th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 194 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031284205
    Series Statement: Cell Biology and Translational Medicine, 1410
    URL: https://doi.org/10.1007/978-3-031-28420-5
    DOI: 10.1007/978-3-031-28420-5
    Language: English
    Note: Monkeypox and Sexually Transmitted Diseases -- Clinical Manifestations of Monkeypox -- Laboratory Diagnosis for Monkeypox: Clinical Practice and Important Points to Be Recognized -- Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent -- HSF1 and Its Role in Huntington's Disease Pathology -- Leveraging Tissue Engineering for Skin Cancer Models -- Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment -- Stem Cell-Derived Extracellular Vesicles as a Potential Therapeutic Tool for Eye Diseases: From Benchtop to Bedside -- Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells -- Direct Reprogramming of Somatic Cells into Induced β-Cells: An Overview.
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    Cell Biology and Translational Medicine, Volume 18 : Tissue Differentiation, Repair in Health and Disease (2023)
    Cham : Springer Nature Switzerland
    Details
    Subject(s): Cytology. ; Stem cells. ; Regenerative medicine. ; Molecular biology. ; Epigenetics. ; Cell Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Molecular Biology. ; Epigenetics.
    In: Springer Nature eBook
    Description / Table of Contents: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 18th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 207 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031284243
    Series Statement: Cell Biology and Translational Medicine, 1409
    URL: https://doi.org/10.1007/978-3-031-28424-3
    DOI: 10.1007/978-3-031-28424-3
    Language: English
    Note: Mitochondrial Permeability Transition in Stem Cells, Development, and Disease -- HSF1, Aging, and Neurodegeneration -- Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects -- Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering -- Therapeutic Perspectives for the Clinical Application of Umbilical Cord Hematopoietic and Mesenchymal Stem Cells: Overcoming Complications Arising After Allogeneic Hematopoietic Stem Cell Transplantation -- Advanced Nanotechnology Approaches as Emerging Tools in Cellular-Based Technologies -- Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology -- The Link Between Heat Shock Proteins, Renin-Angiotensin System, and the Coagulation Cascade in the Pathogenesis of the Coronavirus-19 Disease -- Aptamer-Based Tumor-Targeted Diagnosis and Drug Delivery -- Heat Shock Proteins: Central Players in Oncological and Immuno-Oncological Tracks.
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    New Horizons in Meiobenthos Research : Profiles, Patterns and Potentials (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Freshwater ecology. ; Marine ecology. ; Invertebrates. ; Biotic communities. ; Biodiversity. ; Applied ecology. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Invertebrate Zoology. ; Ecosystems. ; Biodiversity. ; Applied Ecology. ; Water.
    In: Springer Nature eBook
    Description / Table of Contents: Since research on meiobenthos was last compiled in a textbook (2008/2009), the number of theoretical and applied studies has been growing rapidly. Supported by new methods and digital evaluation, meiobenthology has developed into a wide field, with more and more researchers studying cross-disciplinary aspects. New perspectives were summarized in a booklet (2019) to draw attention to promising research directions. The present book, written by leading experts, is a compilation of new thinking, data, methods and approaches in many relevant fields of recent meiobenthos research. The topics addressed range from bacteria and biofilms to globally changing processes, from polar regions to the deep-sea and from freshwater ecosystems to the ocean. So, this book is not simply another meiobenthos textbook - it is an attempt to identify new horizons in meiobenthos research, driven by the vision of advancing knowledge and understanding of benthic ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 407 p. 50 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031216220
    URL: https://doi.org/10.1007/978-3-031-21622-0
    DOI: 10.1007/978-3-031-21622-0
    Language: English
    Note: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.
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  • 142
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    Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Neurosciences. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry.
    In: Springer Nature eBook
    Description / Table of Contents: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
    Type of Medium: Online Resource
    Pages: XVII, 554 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811973765
    Series Statement: Advances in Experimental Medicine and Biology, 1411
    URL: https://doi.org/10.1007/978-981-19-7376-5
    DOI: 10.1007/978-981-19-7376-5
    Language: English
    Note: 1.How Immune-inflammatory processes link neurodegenerative and psychiatric disorders -- 2.Gut-Microbiota-Brain Axis: pathophysiological mechanism in neuropsychiatric disorders -- 3.Microbiome- induced autoimmunity and novel therapeutic intervention -- 4.The key role of microlia and circulating monocytes in etipathology neuropsychiatric disorders -- 5.Neuro-immuno-epigenetics of prenatal psychological stress -- 6.C-reactive protein (CRP): a potent inflammation biomarker in psychiatric disorders -- 7.Neuroinflammation, neurognesis and neuroprotection in schizophrenia -- 8.Autoimmue psycosis: concept, clinical manifestation and management -- 9.Stress, autonomic nervous system and kynurenine pathway in major depression -- 10.Brain-gut-microbiome axis in major depression : novel therapeutic approach -- 11.Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder -- 12.Neuroimmaging of inflammation in depression and anxiety disorders -- 13.Neuroinflammation and immune-kynureinine pathway in anxiety disorders -- 14.Inflammatory-mediated responses in development of neurogeneartive diseases -- 15.The connection between gut-brain axis and PTSD -- 16.Eating disorders : Gut microbiota-immune-brain interactions -- 17.Sleep-immune crosstalk and sleep disorders -- 18.Obsessive-compulsive disorder: immuno-inflammatory disorder? -- 19.Cytokine, neuroinflammation and neurodeneration in Alzheimer’s disease -- 20.Molecular imaging of neuroinflammation in Alzheimer's disease and MCI -- 21.The role of N-Methyl-D-Aspartate Receptor Neurotransmission and mictobiota in Alzheimer’s disease -- 22.Neuroglial activation and neuroinflammation in the brain of patients with autism -- 23.Suicide and inflammation -- 24.Anti-inflammatory effect of Traditional Chinese Medicine on the concept of Mind-body interface -- 25.Anti-inflammatory therapy as a promising target in neupsychiatric disorders.
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    Visceral Pain (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    In: Springer Nature eBook
    Description / Table of Contents: The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
    Type of Medium: Online Resource