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1.
PAPER CURRENT
Entropy, Vol. 20, Pages 614: Study of Geo-Electric Data Collected by the Joint EMSEV-Bishkek RS-RAS Cooperation: Possible Earthquake Precursors (2018)
MDPI Publishing
Publication Date: 2018-08-19
Description: Entropy, Vol. 20, Pages 614: Study of Geo-Electric Data Collected by the Joint EMSEV-Bishkek RS-RAS Cooperation: Possible Earthquake Precursors Entropy doi: 10.3390/e20080614 Authors: Konstantina Papadopoulou Efthimios Skordas Jacques Zlotnicki Toshiyasu Nagao Anatoly Rybin By employing the cross-correlogram method, in geo-electric data from the area of Kyrgyzstan for the period 30 June 2014–10 June 2015, we identified Anomalous Telluric Currents (ATC). From a total of 32 ATC after taking into consideration the electric current source properties, we found that three of them are possible Seismic Electric Signal (SES) activities. These three SES activities are likely to be linked with three local seismic events. Finally, by studying the corresponding recordings when a DC alternating source injects current into the Earth, we found that the subsurface resistivity seems to be reduced before one of these three earthquakes, but a similar analysis for the other two cannot be done due to their large epicentral distance and the lack of data.
Electronic ISSN: 1099-4300
Topics: Chemistry and Pharmacology , Physics
Published by MDPI Publishing
2.
PAPER CURRENT
Cancers, Vol. 10, Pages 274: Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance (2018)
Molecular Diversity Preservation International (MPDI)
Publication Date: 2018-08-19
Description: Cancers, Vol. 10, Pages 274: Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance Cancers doi: 10.3390/cancers10080274 Authors: Babak Nami Zhixiang Wang Taxanes are a class of chemotherapeutic agents that inhibit cell division by disrupting the mitotic spindle through the stabilization of microtubules. Most breast cancer (BC) tumors show resistance against taxanes partially due to alterations in tubulin genes. In this project we investigated tubulin isoforms in BC to explore any correlation between tubulin alterations and taxane resistance. Genetic alteration and expression profiling of 28 tubulin isoforms in 6714 BC tumor samples from 4205 BC cases were analyzed. Protein-protein, drug-protein and alterations neighbor genes in tubulin pathways were examined in the tumor samples. To study correlation between promoter activity and expression of the tubulin isoforms in BC, we analyzed the ChIP-seq enrichment of active promoter histone mark H3K4me3 and mRNA expression profile of MCF-7, ZR-75-30, SKBR-3 and MDA-MB-231 cell lines. Potential correlation between tubulin alterations and taxane resistance, were investigated by studying the expression profile of taxane-sensitive and resistant BC tumors also the MDA-MB-231 cells acquired resistance to paclitaxel. All genomic data were obtained from public databases. Results showed that TUBD1 and TUBB3 were the most frequently amplified and deleted tubulin genes in the BC tumors respectively. The interaction analysis showed physical interactions of α-, β- and γ-tubulin isoforms with each other. The most of FDA-approved tubulin inhibitor drugs including taxanes target only β-tubulins. The analysis also revealed sex tubulin-interacting neighbor proteins including ENCCT3, NEK2, PFDN2, PTP4A3, SDCCAG8 and TBCE which were altered in at least 20% of the tumors. Three of them are tubulin-specific chaperons responsible for tubulin protein folding. Expression of tubulin genes in BC cell lines were correlated with H3K4me3 enrichment on their promoter chromatin. Analyzing expression profile of BC tumors and tumor-adjacent normal breast tissues showed upregulation of TUBA1A, TUBA1C, TUBB and TUBB3 and downregulation of TUBB2A, TUBB2B, TUBB6, TUBB7P pseudogene, and TUBGCP2 in the tumor tissues compared to the normal breast tissues. Analyzing taxane-sensitive versus taxane-resistant tumors revealed that expression of TUBB3 and TUBB6 was significantly downregulated in the taxane-resistant tumors. Our results suggest that downregulation of tumor βIII- and βV-tubulins is correlated with taxane resistance in BC. Based on our results, we conclude that aberrant protein folding of tubulins due to mutation and/or dysfunction of tubulin-specific chaperons may be potential mechanisms of taxane resistance. Thus, we propose studying the molecular pathology of tubulin mutations and folding in BC and their impacts on taxane resistance.
Electronic ISSN: 2072-6694
Topics: Medicine
3.
PAPER CURRENT
Entropy, Vol. 20, Pages 615: Second Law Analysis of Dissipative Flow over a Riga Plate with Non-Linear Rosseland Thermal Radiation and Variable Transport Properties (2018)
MDPI Publishing
Publication Date: 2018-08-19
Description: Entropy, Vol. 20, Pages 615: Second Law Analysis of Dissipative Flow over a Riga Plate with Non-Linear Rosseland Thermal Radiation and Variable Transport Properties Entropy doi: 10.3390/e20080615 Authors: Muhammad Idrees Afridi Muhammad Qasim Abid Hussanan In this article, we investigated entropy generation and heat transfer analysis in a viscous flow induced by a horizontally moving Riga plate in the presence of strong suction. The viscosity and thermal conductivity of the fluid are taken to be temperature dependent. The frictional heating function and non-linear radiation terms are also incorporated in the entropy generation and energy equation. The partial differential equations which model the flow are converted into dimensionless form by using proper transformations. Further, the dimensionless equations are reduced by imposing the conditions of strong suction. Numerical solutions are obtained using MATLAB boundary value solver bvp4c and used to evaluate the entropy generation number. The influences of physical flow parameters arise in the mathematical modeling are demonstrated through various graphs. The analysis reveals that velocity decays whereas entropy generation increases with rising values of variable viscosity parameter. Furthermore, entropy generation decays with increasing variable thermal conductivity parameter.
Electronic ISSN: 1099-4300
Topics: Chemistry and Pharmacology , Physics
Published by MDPI Publishing
4.
PAPER CURRENT
Publication Date: 2018-08-19
Description: IJERPH, Vol. 15, Pages 1778: Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15081778 Authors: Isabelle Nogueira Leroux Ana Paula Sacone da Silva Ferreira Fernanda Pollo Paniz Tatiana Pedron Fernanda Junqueira Salles Fábio Ferreira da Silva Heloisa França Maltez Bruno Lemos Batista Kelly Polido Kaneshiro Olympio Lead, known as a metal with high neurotoxicity to children, cadmium, which is a carcinogenic and bioaccumulative contaminant, and arsenic, a class 1 carcinogenic according to the International Agency for Research on Cancer, are toxic elements (TEs) whose relevant route of exposure may be diet. We determined the bio-accessible fraction of lead, cadmium, and arsenic from the diet of preschool children from two day care centers (DCC). A cross-sectional study was conducted with 64 one–four-year-old children from two DCCs where the 24-h duplicate diet samples were collected. The diet samples were analyzed by ICP-MS for lead, cadmium, and arsenic total concentrations (n = 64) and their bio-accessibility were analyzed for a subsample (n = 10). The dietary intake (DI) mean for lead, cadmium, and arsenic were 0.18 ± 0.11 µg kg−1 bw, 0.08 ± 0.04 µg kg−1 bw, and 0.61 ± 0.41 µg kg−1 bw, respectively. All DI calculated for TEs, considering total intake, were found lower than the tolerable limits (TL) (European Union, or World Health Organization, WHO, when applicable) except for one child’s Pb intake. Bio-accessibilities ranged between 0% to 93%, 0% to 103%, and 0% to 69%, for lead, cadmium, and arsenic, respectively. Although DI for TEs has been found lower than TL, these reference values have been recently decreased or withdrawn since it was for lead and arsenic whose TL were withdrawn by WHO.
Print ISSN: 1661-7827
Electronic ISSN: 1660-4601
Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
Published by MDPI Publishing
5.
PAPER CURRENT
IJERPH, Vol. 15, Pages 1777: Aluminium in Brain Tissue in Multiple Sclerosis (2018)
MDPI Publishing
Publication Date: 2018-08-19
Description: IJERPH, Vol. 15, Pages 1777: Aluminium in Brain Tissue in Multiple Sclerosis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15081777 Authors: Mold Chmielecka Rodriguez Thom Linhart King Exley Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence microscopy. The aluminium content of brain tissue in MS was universally high with many tissues bearing concentrations in excess of 10 μg/g dry wt. (10 ppm) and some exceeding 50 ppm. There were no statistically significant relationships between brain lobes, donor age or donor gender. Aluminium-specific fluorescence successfully identified aluminium in brain tissue in both intracellular and extracellular locations. The association of aluminium with corpora amylacea suggests a role for aluminium in neurodegeneration in MS.
Print ISSN: 1661-7827
Electronic ISSN: 1660-4601
Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
Published by MDPI Publishing
6.
PAPER CURRENT
IJERPH, Vol. 15, Pages 1776: Contaminations of Soil and Two Capsicum annuum Generations Irrigated by Reused Urban Wastewater Treated by Different Reed Beds (2018)
MDPI Publishing
Publication Date: 2018-08-19
Description: IJERPH, Vol. 15, Pages 1776: Contaminations of Soil and Two Capsicum annuum Generations Irrigated by Reused Urban Wastewater Treated by Different Reed Beds International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15081776 Authors: Almuktar Abed Scholz Background: In order to save potable water, this study aims to evaluate the contamination of soil and Capsicum annuum L. (chilli) watered with urban wastewater (sewage) pre-treated by various wetland systems. Methods: The appropriateness of wetland outflow for irrigation when applying reused wastewater with high contamination of minerals and pathogens was assessed. The impact of wastewaters pre-treated by various wetlands on soil and harvest was tested in terms of mineral and biological contamination risk. Results: The wetlands met the standards for irrigation water for most water quality variables. However, the thresholds for key water quality parameters were significantly (p < 0.05) exceeded. The highest values for total coliforms, ammonium-nitrogen, phosphorus and potassium were 157,072 CFU/100 mL, 8.5 mg/L, 5.0 mg/L, and 7.0 mg/L, respectively. The harvest was moderately polluted only by zinc according to vegetable quality standards (threshold of 50 mg/kg). Zinc concentrations for Filters 2, 4, 6, 7 and 8 were 35.8, 60.6, 65.1, 65.5 and 53.2 mg/kg, respectively. No bacterial contamination was detected. Conclusions: Treatment of domestic wastewater applying constructed wetlands and subsequent recycling of the treated wastewater for irrigation of crops is a good substitute to the traditional application of drinking water for irrigation purposes.
Print ISSN: 1661-7827
Electronic ISSN: 1660-4601
Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
Published by MDPI Publishing
7.
PAPER CURRENT
[ASAP] Tuning the Reactivity of Peroxo Anhydrides for Aromatic C–H Bond Oxidation (2018)
American Chemical Society (ACS)
Publication Date: 2018-08-19
Description: The Journal of Organic Chemistry DOI: 10.1021/acs.joc.8b01392
Print ISSN: 0022-3263
Electronic ISSN: 1520-6904
Topics: Chemistry and Pharmacology
8.
PAPER CURRENT
[ASAP] Sulfoximine-Assisted One-Pot Unsymmetrical Multiple Annulation of Arenes: A Combined Experimental and Computational Study (2018)
American Chemical Society (ACS)
Publication Date: 2018-08-19
Description: The Journal of Organic Chemistry DOI: 10.1021/acs.joc.8b01077
Print ISSN: 0022-3263
Electronic ISSN: 1520-6904
Topics: Chemistry and Pharmacology
9.
PAPER CURRENT
IJERPH, Vol. 15, Pages 1775: Socioeconomic Factors and Caries in People between 19 and 60 Years of Age: An Update of a Systematic Review and Meta-Analysis of Observational Studies (2018)
MDPI Publishing
Publication Date: 2018-08-19
Description: IJERPH, Vol. 15, Pages 1775: Socioeconomic Factors and Caries in People between 19 and 60 Years of Age: An Update of a Systematic Review and Meta-Analysis of Observational Studies International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15081775 Authors: Simone M. Costa Carolina C. Martins Mânia Q. C. Pinto Mara Vasconcelos Mauro H. N. G. Abreu This study is aimed to perform an update of a systematic review and meta-regression to evaluate the effect modification of the socioeconomic indicators on caries in adults. We included studies that associated social determinants with caries, with no restriction of year and language. The Newcastle-Ottawa Scale was used to evaluate the risk of bias. With regard to the meta-analysis, statistical heterogeneity was evaluated by I2, and the random effect model was used when it was high. A subgroup analysis was conducted for socioeconomic indicators, and a meta-regression was performed. Publication bias was assessed through Egger’s test. Sixty-one studies were included in the systematic review and 25 were included in the meta-analysis. All of the studies were published between 1975 and 2016. The most frequent socioeconomic indicators were schooling, income, and socioeconomic status (SES). In the quantitative analysis, the DMFT (decayed, missing, filled teeth) variation was attributed to the studies’ heterogeneity. The increase of 10.35 units in the proportion of people with lower SES was associated with an increase of one unit in DMFT, p = 0.050. The findings provide evidence that populations with the highest proportions of people with low SES are associated with a greater severity of caries. The results suggest the need for actions to reduce the inequalities in oral health (PROSPERO [CRD42017074434]).
Print ISSN: 1661-7827
Electronic ISSN: 1660-4601
Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
Published by MDPI Publishing
10.
PAPER CURRENT
[ASAP] Effects of Oligomer Length, Solvents, and Temperature on the Self-Association of Aromatic Oligoamide Foldamers (2018)
American Chemical Society (ACS)
Publication Date: 2018-08-19
Description: Organic Letters DOI: 10.1021/acs.orglett.8b02438
Print ISSN: 1523-7060
Electronic ISSN: 1523-7052
Topics: Chemistry and Pharmacology