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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a double-blind, placebo-controlled crossover study in eight male volunteers, toe-arm systolic gradients, measured with strain-gauge plethysmography, were measured for 4 h after 2 mg intravenous GR43175 or placebo. No changes were observed, indicating that GR43175 is without significant vasoconstrictor effect on peripheral arteries in man.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There has been much discussion about the role of platelets in the pathogenesis of migraine. A new in vitro technique using a custom built device called the Haemostatometer measures haemostasis, thrombolysis, and coagulation from non-anticoagulated, undiluted (native) blood. Using this device, data were analysed from blood samples taken from 10 migraineurs between attacks and 10 control subjects. Results showed no difference in haemostasis, spontaneous thrombolysis or coagulation between migraineurs and control subjects.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pressor responsiveness to phenylephrine, an almost pure agonist of peripheral alpha-1-adrenoceptors, was studied in 32 migraine patients in headache-free intervals. Eighteen healthy volunteers served as a control group. Fourteen patients and 14 controls also underwent the tilt test. The following observations were made: (1) the pressor response to phenylephrine was significantly greater and longer lasting in patients than in controls; (2) the reflex decrease of heart rate did not differ in the two groups; (3) a normal orthostatic increase of blood pressure and heart rate occurred in migraineurs with hyperresponsiveness to phenylephrine. These findings suggest a supersensitivity of vascular adrenoceptors which is compatible with a chronic adrenergic deficiency in migraineurs. Since patients did not show an orthostatic hypotension in attack-free periods, the compensatory character of receptoral supersensitivity and the possible mechanisms of cardiovascular dysautonomia, which may occur during migraineous attack, were discussed.
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  • 6
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The first case of Hemicrania continua in Greece is reported; a female of 47 years with a 17-year history of right-sided headache. For the last year, she had a moderate pain on the left side (amounting to 10–15% of the right-sided one and occurring only occasionally, i.e. when the right-sided pain was severe). After 17 years the pain still had a remitting course with pain periods of around three weeks interrupted by pain-free periods of approximately ten days. The indomethacin effect is complete.
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  • 8
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this investigation was to evaluate whether the pain of cervicogenic headache could be due to referred symptoms from myofascial trigger points. The presence or absence of cervical spine dysfunction was also of interest. Eleven patients with cervicogenic headaches were systematically examined for myofascial trigger points and cervical spine dysfunction. All patients had at least three myofascial trigger points on the symptomatic side. In eight of these patients, trigger point palpation clearly reproduced their headache. There were 70 myofascial trigger points (35 “very tender”, 35 “tender”) and 17 non-myofascial tender points on the symptomatic side, compared to 22 myofascial trigger points (one “very tender”, 21 “tender”) and 19 non-myofascial tender points on the asymptomatic side. These differences were statistically significant [chi-square (2df) = 22.04, p 〈 0.0001]. All patients had some evidence of cervical dysfunction. Ten patients (91% ) had specific segmental dysfunction of occiput on atlas andor atlas on axis. Five patients were entered into a non-invasive, interdisciplinary pain management program designed to treat cervical spine dysfunction and myofascial pain. Treated patients reported a significant decrease in the frequency and intensity of their headaches during a median two-year follow-up. It is concluded that myofascial trigger points may be an important pain producing mechanism in cervicogenic headache and that segmental cervical dysfunction is a common feature in such patients. Conservative, non-surgical treatment appears to be effective in reducing the frequency and intensity of cervicogenic headache. These data suggest that surgical approaches should be reserved only for those patients who fail conservative therapy.
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  • 9
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of a range of prostanoids on human and rabbit basilar arteries precontracted in vitro in the presence of the thromboxane receptor-blocking drug AH23848B was investigated. On the rabbit basilar artery and in the presence of AH23848B the thromboxane A2 mimetic U-46619 produced further concentration-related contractions of the tissue. All other prostaglandins (except ICI81008 and PGF2a which had no effect) produced concentration-related relaxations with the rank order of relaxant potency being PGE2 〉 Iloprost 〉 PGI2 = PGE1 = 16,16-dimethyl PGE2 = PGD2. On the human basilar artery PGI2 and iloprost produced concentration-related relaxations with iloprost being more potent than PGI2. At high concentrations both these compounds produced reduced relaxant responses. All other prostanoids (except ICI81008 and PGD2 which had no effect) contracted the tissue, the rank order of contractile potency being 16, 16-dimethyl PGE2 〉 PGE2 〉 PGF2a = PGE1 〉 U46619 〉〉 ICI81008 and PGD2. It is concluded that the human basilar artery possesses two contractile prostanoid receptors, a TP receptor and one which may be of the EP-type in addition to a prostanoid receptor mediating relaxation which may be of the IP-type. The prostanoid receptor(s) mediating relaxation of the rabbit in vitro basilar artery is difficult to determine. The relevance of the observations to cerebrovascular disorders such as migraine and vasospasm is discussed.
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  • 10
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of prophylactic treatment with sodium valproate in cluster headache was investigated in an open pilot study. Fifteen cluster headache patients were studied of whom two suffered from chronic cluster headache and thirteen from the episodic type. The dose used was between 600 and 2000 mg per day in two divided doses. Eleven out of the fifteen patients (73.3%) reacted favorably to the treatment. Nine reported a complete disappearance of pain and two, a marked improvement. Sodium valproate appears to be an effective drug in the treatment of cluster headache. A double-blind controlled study is needed for further evaluation.
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