Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1437-7799
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1437-7799
    Keywords: unilateral cystic disease ; computed tomographic scan ; autosomal dominant polycystic kidney disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of unilateral renal cystic disease in a 68-year-old man. He had no family history of renal cystic disease, and his serum creatinine level was 1.2 mg/dL. The computed tomographic scan revealed near-complete replacement of the right kidney by numerous cysts and almost no residual parenchyma. The left kidney was normal, and there were no hepatic or pancreatic cysts. Magnetic resonance imaging showed numerous cysts in the right kidney and a normal left kidney. The cysts showed homogeneously low intensity on T1-weighted images and homogeneously high intensity on T2-weighted images. The disease in our patient was compatible with unilateral renal cystic disease as defined by Levine and Huntrakoon, and was distinct from autosomal dominant polycystic disease and other unilateral cystic diseases of the kidney. Our literature survey revealed no report of unilateral renal cystic disease in Japan.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1437-7799
    Keywords: Saireito ; cystitis ; Chinese herbal medicine ; complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe 2 children with sterile cystitis caused by Saireito, a traditional Chinese herbal medicine. A diagnosis of cystitis was made for 1 child at 8 months and for the other at 11 months after Saireito treatment for renal disease was initiated. Clinical symptoms were resolved 1 and 6 weeks after Saireito treatment was withdrawn. We also reviewed the first report written in the English language on 8 additional patients with Saireito-induced cystitis. We found that Saireito-induced cystitis occurred mainly in children and developed 6 months or more after Saireito treatment was initiated. The incidence is not uncommon, and the cause may be an allergic reaction, because eosinophilic cell infiltration was noted on histopathologic examination, and the challenge test was positive. We recommend that, when sterile cystitis develops during treatment with Saireito, Saireito should be immediately withdrawn.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1437-7799
    Keywords: gene trasfer ; gene therapy ; adenovirus ; liposome ; oligonucleotide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Progress in gene transfer technology has established the scientific basis for molecular approaches to human diseases. In the kidney, the first trial of gene transfer was reported in 1991, and several strategies have been developed during the past years. Successful gene transfer into specific renal structures allows for evaluation of in vivo effects of certain molecules on the structure and function of the kidney. It would also be useful for therapeutic intervention in renal diseases by introducing “beneficial” genes into the affected sites. By introducing viral vectors or liposomes via particular access routes, it is feasible to selectively manipulate function of certain renal structures. Through the renal circulation, exogenous genes can be targeted to the vasculature, glomeruli and proximal tubules. Using a retrograde approach via the urinary tract, access to collecting ducts is possible. Implantation of genetically modified cells under the capsule of the kidney allows for diffusion of transgene products into the interstitium. Transplantation of embryonic metanephric kidneys also provides a biological window for renal gene transfer. Furthermore, germline gene manipulations are becoming realistic strategies for creation of “transgenic kidneys” and “gene knockout kidneys.’ This article summarizes the current experince with gene transfer into the kidney and addresses its potential impact on nephrology.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1437-7799
    Keywords: paroxysmal nocturnal hemoglobinuria ; acute renal failure ; Fanconi's syndrome ; hemosiderosis ; urinaryβ 2-microglobulin ; x-ray analysis ; iron metal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 41-year-old man with aplastic anemia and paroxysmal nocturnal hemoglobinuria complex presented with complaints of frequent episodes of acute renal failure associated with hemolytic attacks. In the last admission he suffered from severe renal dysfunction that required hemodialysis for 3 weeks. A renal biopsy sample showed normal appearing of glomeruli and a moderate degree of tubular atrophy, probably due to massive ferrous deposition which was confirmed by x-ray analysis. He was found to have Fanconi's syndrome, with phosphaturia, uricosuria, acidic aminoaciduria, and excessive urinaryβ 2-microglobulin excretion. This is a case in which paroxysmal nocturnal hemoglobinuria caused frequent episodes of acute renal failure and a coincident Fanconi's syndrome.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1437-7799
    Keywords: leptin ; kidney transplantation ; prednisolone ; cyclosporin ; obesity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Although recipients of kidney transplantation tend to be obese, the factors that cause obesity, including steroid and cyclosporin administration after kidney transplantation, are not fully understood. Because leptin, the gene product of theob gene, has been shown to play an important role in controlling the appetite in rodents, it might have a similar role in humans. Methods We examined the serum leptin concentration in 16 patients who had undergone kidney transplantation. The transplantation group was matched with a control group by age, body mass index, and serum creatinine level. Results The serum leptin concentration of the kidney transplantation group was significantly higher than that of the control group. The results also indicated that serum leptin concentration was related to body mass index, serum insulin, and triglyceride concentration in the kidney transplantation group. A significant correlation was also found between the serum insulin level and the triglyceride concentration in the transplantation group. The serum leptin concentration was not related to dosage of maintenance prednisolone, total prednisolone, maintenance cyclosporin, total cyclosporin, nor to the cyclosporin trough level. Conclusions The serum leptin concentration was related to the body mass index and concentrations of serum insulin and triglyceride, but was not related to the doses of administored prednisolone and cyclosporin.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1437-7799
    Keywords: C3 ; glomerulonephritis ; nephrotic syndrome ; in situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background The histologic diagnosis and clinical findings of glomerulonephritis are very important for determining the treatment strategies. Contrary to expectation, some patients with glomerulonephritis get worse and progress into endstage renal disease. Renal deposition of C3 cleavage products are significant in the pathogenesis and development of glomerulonephritis. Recently, some investigators have reported local C3 synthesis in human renal tissue, and have suggested that it contributes to local inflammatory disorders. The purpose of this study was to explore further the clinicopathologic significance of renal C3 mRNA expression. Methods We examined C3 mRNA expression in kidney tissues (2 normal and 18 diseased) by using nonradioactive, in situ hybridization, and compared results with clinicopathologic findings. Results In all diseased kidney specimens, proximal tubules had C3 mRNA-positive cells. In some cases of minimal-change nephrotic syndrome, lupus nephritis, and membranoproliferative glomerulonephritis, C3 mRNA-positive cells were found in the glomerulus. Specimens from patients with lupus nephritis showed C3 mRNA expression not only in in their tubules and glomeruli, but also in invasive, inflammatory cells. However, no signal was observed in the normal kidney specimens Cases with severe nephrotic conditions and/or with tubular injury showed strong expression. Conclusions These data indicate that renal C3 mRNA that could not been detected by routine immunohistologic methods is, in fact, detectable during the active stage of disease. Therefore detection of renal C3 mRNA may give us new information for assessing pathologic activities, and may be an effective means for determining the prognosis of patients with glomerulonephritis.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1437-7799
    Keywords: pyridinoline ; pyridinoline cross-linked carboxy terminal telopeptide of type i collagen ; bone resorption ; bone metabolic marker ; chronic renal failure ; hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Serum levels of pyridinoline, measured by high-performance liquid chromatography, and pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), measured by a newly developed radioimmunoassay kit, were compared and analyzed to determine whether ICTP can replace pyridinoline as a marker of bone resorption in hemodialysis patients. Methods Thirty-five patients receiving maintenance hemodialysis were studied. Ten of the 35 patients were selected for an investigation of the kinetics of ICTP during hemodialysis treatment to compare with that of pyridinoline. Pyridinoline, ICTP, and other known bone metabolic markers were measured in all 35 patients immediately before hemodialysis. The correlation between pyridinoline and ICTP was analyzed by using relative amounts of these markers and the findings of bone resorption on a plain roentgenogram of the hands. Results The mean removal and recovery rates of ICTP were 25.3% and 103.4%, respectively. The correlation coefficient between pyridinoline and ICTP was 0.756 (P〈0.001). Pyridinoline, but not ICTP, positively correlated with intact parathryroid hormone (iPTH) and osteocalcin. A higher correlation was shown between iPTH and pyridinoline than between iPTH and ICTP. ICTP was better correlated with lower levels of pyridinoline (r=0.651,P〈0.005) than higher ones (r=0.230, not significant). A positive correlation was observed between pyridinoline and ICTP in patients without subperiosteal resorption. Conclusion ICTP is not superior to pyridinoline as a marker of bone resorption in hemodialysis patients, especially in those with a progressed state of bone resorption.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1437-7799
    Keywords: Alport syndrome ; type IV collagen ; hereditary nephritis ; immunohistochemistry ; monoclonal antibody ; antigen retrieval
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Autosomal-dominant Alport syndrome is a recognized, but relatively uncommon, form of Alport syndrome. Recently, mutations in theCOL4A3 andCOL4A4 genes, which encode collagen type IV α3 and α4 chains, respectively, have been shown to cause the disease. However, the distribution of α(IV) chains has yet to be determined. Methods To clarify the renal distribution of α(IV) chains, immunohistochemistry of α1(IV) to α6(IV) chains was performed, using chain-specific monoclonal antibodies, raised by us, and an antigen retrieval procedure. Paraffin-embedded renal sections, obtained from 8 patients from 3 families with the disease, were examined. Results The distribution of all 6 α(IV) chains was not significantly different between the 8 patients and the controls. Collagen type IV α1 and α2 chains were ubiquitously expressed, while α3 to α6 chains were detected in the basement membranes of the glomerulus and Bowman's capsule, and/or part of the tubular basement membranes. Conclusions Our findings contrast with those of X-linked and autosomal-recessive Alport syndrome. The distribution pattern of α(IV) chains may provide a useful means of distinguishing the different forms of Alport syndrome.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1437-7799
    Keywords: renal artery ; hypertension ; stenosis ; stent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In recent years, transluminal vascular stents have been implanted in patients with renal artery stenosis. At present, controversy remains as to whether the long-term outcome of stent implantation is better than that of percutaneous transluminal renal angioplasty (PTRA). However, until now, no clinical experience of a stent placement for renal artery stenosis has been reported in our country. We implanted a Palmaz stent in a patient with renovascular hypertenstion due to renal artery restenosis who had already undergone PTRA. The renal function and blood pressure of the patient improved remarkably.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...