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  • 1
    ISSN: 1434-9949
    Keywords: Ankulosing spondylitis ; Microradiography ; Tetracycline labelling ; Calcified elastin ; Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five spine specimens obtained at autopsy and five biopsies of sacroiliac joints from subjects with ankylosing spondylitis were submitted to microradiography and to fluorescence microscopy for detection of tetracycline. Decalcified histological sections were also prepared. Microradiography provides a link between the clinical X-ray picture and the classical decalcified section; it enables calcified cartilage, and hence the early stage of most syndesmophytes to be recognised more easily and accurately; It revealed a peculiar calcification of elastic fibers of the ligamentum flavum. Tetracycline labels showed that: in an early case of sacro-iliac arthritis, calcification of the articular cartilage might partly explain the desification of the X-ray picture; syndesmophytes were thickening at both their superficial and deep faces; thickening, lengthening and internal remodelling of the intervertebral bridges occured together; and calcium was deposited at the end-plates as well.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 1 (1982), S. 79-79 
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 1 (1982), S. 126-127 
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Lymphoedema ; Upper Limb ; Lymphangiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bilateral upper limb oedema due to lymphatic obstruction, is an uncommon complication of rheumatoid arthritis (R.A.). We report a case in which a 40 year old male with seropositive rheumatoid arthritis developed gross pitting oedema of the left arm. Lymphangiography showed lymphatic obstruction in both arms; within two months the right arm also became oedematous.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 1 (1982), S. 128-130 
    ISSN: 1434-9949
    Keywords: Ibuprofen ; Mixed connective tissue disease ; Meningitis ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A young Black woman with mixed connective tissue disease (MCTD) developed an aseptic meningitis after receiving ibuprofen. The meningeal reaction, reported infrequently in systemic lupus erythematosus (SLE) and only once previously in MCTD, was characterized by a predominantly polymorphonu-clear cerebrospinal fluid (CSF) pleocytosis and depression of CSF glucose. Reversible renal insuffiency also occurred. Features suggestive of a hypersensitivity reaction included pruritus, conjunctivitis, facial oedema, desquamation of the palms and soles, and subsequent near total alopecia. Meningeal signs responded rapidly to systemic corticosteroid therapy. Patients with MCTD as well as those with SLE may be at peculiar risk of developing this uncommon reaction to ibuprofen.
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  • 6
    ISSN: 1434-9949
    Keywords: Behçet's disease/syndrome ; Lymphycyte studies ; Neurological complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We rapport here a case of Behcet's disease presenting with neurological complications who made a remarkable recovery to high dose steroids and azathioprine. Prior to initiation of steroid therapy the percentage of T lympho-cytes (OKT3) was low, that of helper T lymphocytes (OKT4) was normal and suppressor T lymphocytes (OKT8) was slightly increased. The OKT4 ∶ OKT8 ratio was slightly reduced and the percentage of B lymphocytes was high. With steroid therapy there was an increase in the percentage of OKT3 and fall in the percentages of OKT4 and OKT8 and the OKT4 ∶ OKT8 ratio was maintained fairly normal. The percentage of B lymphocytes was reduced. On addition of azathioprine the percentage of OKT3 and OKT8 were substantially increased and the percentage of OKT4 was slightly increased. The net result was a significant reduction in the OKT4∶ OKT8 ratio. The percentage of B lyphocytes remained normal. On reviewing the absolute counts there was a paradoxical rise in OKT4 and OKT8 a week after high dose steroid therapy due to a substantial rise in the total number of lymphocytes. On reducing the dose of steroids the absolute count of OKT4 and OKT8 decreased in parallel with their percentages. A disparity was noted in the percentage of OKT3 and the sum of the percentages of OKT4 and OKT8, prior to commencement of therapy which was significantly reduced after treatment. It is likely that this disparity is due to the presence of doubly labelled cells (cortical thymocytes) released into circulation prematurely.
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  • 7
    ISSN: 1434-9949
    Keywords: Immunological studies ; Rheumatoid arthritis ; Azathioprine ; Myocrisin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-one patients with classical or definite rheumatoid arthritis (RA), on treatment with azathioprine and sodium aurothiomalate in combination were studied. Absolute lymphocyte counts and IgA levels were reduced but this did not reach statistical significance. Lymphocyte transformation with phytohaemagglutinin (PHA) showed no significant difference from a control group. However, antibody dependent cell-mediated cytotoxicity was significantly impaired compared to rheumatoid controls (p〈0.001). There was no relation to the degree of impairment of ADCC and the current dose of azathioprine nor to the total dose or duration of therapy. Inhibiting material to cell-mediated cytotoxicity was present in the sera of 23 patients but its presence showed no relation to the degree of cytotoxicity exhibited by cells in the same patient. Our studies of cellular cytotoxicity have revealed alterations in cellular function possibly attributable to azathioprine.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 1 (1982), S. 190-193 
    ISSN: 1434-9949
    Keywords: Rheumatoid arthritis ; osteoarthrosis ; vitamin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The investigation concerned changes in vitamin A derivatives (retinol and retinyl) content in serum of patients suffering from two types of rheumatic diseases — rheumatoid arthritis (RA) and osteoarthrosis. Healthy women of similar age served as control. It was found that the retinol content of the serum in the group suffering from RA was significantly (P〈0.001) lower than that of the control group, while in the group suffering from osteoarthrosis it was significantly higher (P〈0,01). The serum retinol content of the group with RA was similar and was not an effect of the corticosteroid treatment. Significant differences were found (P〈0,01) between the groups suffering from RA and osteoarthrosis in the serum content of the retinol. The retinyl content of the serum showed a significant (P〈0.05) difference between the groups afflicted with RA and osteoarthrosis.
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  • 9
    ISSN: 1434-9949
    Keywords: T-cell subsets ; Low dose prednisolone ; Rheumatoid arthritis ; Monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of a single dose of 5 and 10 mg of prednisolone on the kinetics of lymphocytes and T lymphocyte subsets were investigated in patients suffering from active rheumatoid arthritis. Six hours after intake of 10 mg of the drug a significant drop in total lymphocyte count, total T-cell numbers and T-helper cell numbers was recorded. The values returned to baseline values within 24 hours. Intake of 5 mg of prednisolone depressed total T-cell count and more particularly the absolute numbers of T-helper cells. No statistically significant changes occurred in T suppressor-cytotoxic cell traffics. The influence on the kinetics of T-helper cells was responsible for a significant decrease of helper/suppressor ratios in the intravascular compartment.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 1 (1982), S. 221-221 
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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