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  • 1
    Abstract: The purpose of our study was to investigate the importance of amniotic fluid (AF) for fetal growth during late gestation using esophageal atresia (EA) patients as a model. In this retrospective cohort study, we compared the z-scores adapted for birth weights (BW z-scores) for each of 517 European newborns with congenital pre-gastric intestinal atresia, i.e., EA, to a European reference population. To account for the influence of the intestinal atresia on fetal growth per se, we compared adapted birth weights for each of 504 European newborns with post colonic intestinal atresia (anorectal malformation (ARM) with atresia of the anus) to the same European reference population. Analysis of the complete cohort showed (i) a significantly higher rate of small for gestational age newborns among EA compared to ARM newborns (p 〈 0.001) and (ii) significantly lower BW z-scores among EA compared to ARM newborns (p 〈 0.001). BW z-scores of EA newborns were significantly lower in term compared to preterm newborns with an inverse correlation with gestational age (GA) (Spearman correlation coefficient, r = -0.185, p 〈 0.001). CONCLUSIONS: Enteral uptake of AF seems to play a pivotal role in fetal growth during late gestation. WHAT IS KNOWN: * Peak velocity of fetal weight gain occurs at 33 weeks of gestation and continues until birth. During this period, fetal growth is mainly characterized by cellular hypertrophy. * Amniotic fluid (AF) comprises large amounts of hormones and growth regulators. What is New: * A significantly higher rate of small for gestational age and lower birth weights and z-scores are observed among newborn infants with congenital pre-gastric intestinal atresia. * These findings suggest that enteral uptake of AF is a major predictor for fetal growth during late gestation.
    Type of Publication: Journal article published
    PubMed ID: 26979529
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  • 2
    Keywords: function ; LEVEL ; LUNG ; INFECTION ; INCREASE
    Type of Publication: Meeting abstract published
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  • 3
    Keywords: NEW-YORK ; RISK ; molecular ; USA ; pediatric ; medulloblastoma ; pediatrics
    Type of Publication: Meeting abstract published
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 107 (1969), S. 15-25 
    ISSN: 1432-1076
    Keywords: Cerebralparese, frühkindliche ; Kryptorchismus ; Carporadiogramm ; Entwicklungsstörung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Einleitend wird die Ätiologie und Klinik des Hodenhochstandes dargestellt. Besonderes Gewicht wird dabei auf die Häufigkeit des Vorkommens gelegt. An Hand einer Untersuchungsgruppe von 87 cerebralparetischen Knaben wird über den auffallend hohen Anteil von Maldescensus beim frühkindlichen Hirnschaden berichtet und der Frage einer Beziehung zu den bekannten Entwicklungsparametern nachgegangen.
    Notes: Summary Etiology and clinical picture of cryptorchidism are given in an introductory review. Special regard is paid to the high frequency of the phenomenon. Using a group of 87 cerebral palsied male children as an example, a surprisingly high number of cases of cryptorchidism are found in cases of cerebral palsy. The question of a probable connexion of these findings with known developmental parameters in discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 107 (1969), S. 87-90 
    ISSN: 1432-1076
    Keywords: Atmung ; Epilepsie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 21 Kindern im Alter von 11/4-12 Jahren mit cerebralen Krampfanfällen unter verschiedenartiger Therapie wurde fortlaufend die Atmung mit Hilfe eines Infrarotanalysators registriert. Es wurden kurzfristige hypoventilatorische Verläufe beobachtet, als deren mögliche Ursache eine cerebrale Hyperämie angesehen wird.
    Notes: Summary The respiration of 21 children aged between 15 months and 12 years suffering from epileptic seizures and treated with various anticonvulsant drugs was continuously minotored with an infrared analyser. The most striking observation was the occurrence of short hypoventilatory courses which lasted for an average of one minute. A cerebral hyperemia is discussed as possible cause of this phenomenon.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 107 (1969), S. 53-73 
    ISSN: 1432-1076
    Keywords: Frühgeborene ; Hautreflexe ; Reflexogene Hautareale ; Konzeptionsalter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 30 Frühgeborenen im Konzeptionsalter von 30–40 Wochen wurde versucht, eine größere Zahl von exterozeptiven Reflexen und Reaktionen auszulösen. Mit standardisierten taktilen Reizen konnten von umschriebenen Hautbezirken aus Kontraktionen isolierter Muskeln oder Muskelgruppen hervorgerufen werden, die zu lokal begrenzten Streck- oder Beugebewegungen führten. Für diese Reflexantworten spielte weder die unterschiedliche Verteilung des Muskeltonus noch die segmentale Übereinstimmung von Dermatomen und Myotomen eine entscheidende Rolle, sondern die Lokalisation des Stimulus: im Rumpfbereich waren die Auslöspunkte für eine Kontraktion direkt über den Muskelbäuchen, an den Extremitäten lagen sie weiter distal über den Sehnenansätzen; für Finger-bzw. Zehenbewegungen schließlich waren die Reflexzonen bis in die acralen Hautareale verschoben; die Reflexantwort erfolgte stets loco stimuli. Die meisten der 82 untersuchten exterozeptiven Reflexe waren bei allen Frühgeborenen ohne Altersabhängigkeit auslösbar; einige ließen sich nur fakultativ hervorrufen, verschiedene Muskeln konnten taktil überhaupt nicht gereizt werden.
    Notes: Summary 82 exteroceptive skin reflexes and responses were examined in 30 premature infants ranging in conceptional age from 30–40 weeks. By means of standardized tactile stimuli to prescribed skin areas, contraction of a single muscle or a muscle group could be elicited, resulting in extension and/or flexion at a specified joint. For these stereotyped responses it was the location of the stimulus which played a major role rather than the different distribution of muscle tonus or the segmental dermatomo-myotomal correspondence: in the trunk and limb girdles, the sensitive (reflexogenic) zones were localized directly over the respective muscle bellies; in the extremities they were more distally over the tendons and for the finger and/or toe movements, they were shifted toward the acral skin areas of the extremities. The motor response always occurred only at the site of stimulation. The majority of the 82 exteroceptive skin reflexes were present in all the premature infants independently of the conceptional age. Several reflexes were inconsistent and there were some muscles which could not be activated by tactile stimulation.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1076
    Keywords: Angeborene Gallengangsatresie ; Intestinale Ausscheidung ; Gallenfarbstoffe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 9 Kindern mit angeborener Gallengangsatresie wurde im Stuhl weder Bilirubin noch Urobilinogen nachgewiesen. Die bei solchen Kindern gelegentlich auftretende Gelbfärbung der Faeces könnte durch bisher nicht genau charakterisierte Abbauprodukte des Bilirubins hervorgerufen worden sein; unter Berücksichtigung der Angaben im Schrifttum kann festgestellt werden, daß nennenswerte Mengen solcher Derivate sicherlich nicht in den Darmtrakt ausgeschieden werden.
    Notes: Summary In nine cases of congenital biliary duct atresia neither bilirubin nor urobilinogen were demonstrable in the stool. It is conceivable that the yellowish discoloration of feces occasionally observed in such children is caused by catabolites of bilirubin which have not yet been identified. A review of the literature in addition to results presented does not suggest that significant amounts of such derivatives are excreted into the intestinal tract.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1076
    Keywords: Phenolrotexkretion ; Fetopathia diabetica ; Nierenphysiologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 54 10 Tage alten Kindern diabetischer Mütter wurde die Phenolrotexkretion untersucht. Zwischen den einzelnen gebildeten Gruppen (postnatal geschädigte und ungeschädigte Neugeborene) ließen sich keine signifikanten Unterschiede der Farbstoffexkretion feststellen. Auch bei dem Vergleich der Ergebnisse mit denen bei Reifgeborenen fanden wir keine statistisch echten Abweichungen.
    Notes: Summary The capacity for the excretion of phenol red was tested in 54 ten-day old newborns from diabetic mothers. The patients were subdivided into two groups: 1. postnatally damaged children, 2. normal newborns. An average dye excretion of 13.2% after 15 min and 50.7% after 120 min was found in group one. The corresponding results in group two were 12.8% and 56,2% resp. The results obtained with these two groups show no statistically significant differences. Also a comparison of the results with those obtained from mature newborns did not yield any significant differences.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1076
    Keywords: Neugeborenen-Erythrocyten ; Erwachsenen-Erythrocyten ; Erythrocyten-Kationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es besteht kein sicherer Unterschied zwischen dem Natrium- und Kaliumgehalt von Neugeborenen- und Erwachsenenerythrocyten. Der absolute Gehalt der Erythrocyten an Kationen hängt weitgehend von der Vorbehandlung der Zellen und von der Meßmethodik ab. Am geeignetsten für Studien über die Permeabilität der Erythrocytenmembran für Kationen ist die hier angewandte flammenphotometrische Bestimmung im Erythrocytenbrei nach Waschen der Zellen mit Cholinchlorid. Die mit dieser Methode bestimmten Kationenkonzentrationen sind relativ niedrig. Die Natriumkonzentrationen stimmen gut mit Ergebnissen anderer Autoren überein, die nach Korrektur des Plasmafaktors gewonnen wurden.
    Notes: Summary No significant differences were observed in the potassium and sodium concentations of erythrocytes of newborn infants and adults. The absolute red cell cation content depends upon the preparation of the cells prior to cation determination by flame photometry. Washing of the cells with isotonic choline chloride seems to be the most suitable method for studies of the passive cation permeability of red cells. When this method was used the intracellular cation concentrations — after correction with the plasma factor — corresponded well to the concentrations measured with radioactive substances.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1076
    Keywords: Corticosteroide ; 11-β-Hydroxycorticosteroide ; Adrenal cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach einleitender Diskussion der Methoden zur fluorometrischen Bestimmung der 11-β-Hydroxycorticosteroide im Plasma oder Serum wird eine Mikromethode in Anlehnung an de Moor beschrieben. Von den bisherigen Methoden erfordert sie den geringsten Zeit- und Arbeitsaufwand. Die Zuverlässigkeitskriterien von Mikro- und entsprechender Makromethode sind identisch. Das pro Einzelbestimmung erforderliche Serumvolumen beträgt 0,1–0,3 ml. Abschließend wird die Verwendung der Methode in der pädiatrisch-endokrinologischen Diagnostik diskutiert.
    Notes: Summary Following a discussion of the known methods for the determination of 11-β-hydroxycorticosteroids in plasma or serum by fluorimetry a micro-method is described. The advantages of this technique lie in its requirement for minimal amounts of time and laboratory procedures. The criteria for reliability and specificity of this micro-method are identical with those of the macro-methods. Not more than 0.1–0.3 ml of plasma are required for a single determination. The application of this method in the field of pediatic endocrinology is discussed.
    Type of Medium: Electronic Resource
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