NUCLEOPHILIC GLYCINE EQUIVALENTS
A series of chirally switchable Ni-II and Pd-II complexes were synthesized and fully characterized by X-ray crystallography and additionally by NMR. It was found that control of the stereochemical preference between (S*,S*) and (S*,R*) diastereomers by substituent modification of the ligand sidearms was possible in the process of crystallization with the preferred coordination of the sidearms generally consistent with expectations based on the electron-donating or -withdrawing properties of the sidearm substituent groups. There were however, quite interesting and unanticipated exceptions counter to chemical intuition and it seems that only for complexes with ortho substituents are strong preferences for the coordination manner necessarily displayed in the solid state based on the electron-withdrawing or -donating properties of the substituents.
Type of Publication:
Journal article published