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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Book Reviewed in this article:Pharmacology and the skin. Vol. 1: Skin pharmacokinetics. B. Shroot et H. Schaefer (Eds).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The interactions between a typical range of perfume materials, alcohol, water, air, elevated temperatures and daylight have been studied. The changes of composition, acidity, peroxide content and the formation of new molecules were followed. The stabilizing effects of UV absorbers, antioxidants and sequestering agents were examined;— the formation of acid reaction products was accelerated by air, temperature, daylight and the presence of natural products;— peroxide formation was accelerated by heat and light and the presence of air; as the acidity increased, the peroxides decomposed;— the acetalization of other aldehydes was accelerated by temperature and daylight and the presence of natural products up to 40% of certain aldehydes may be converted into acetals after 3 months at 37°C;— many stereoisomerizations occur, e.g., transisoeugenol is converted up to 10% into the cis isomer after 3 months at 37°C and 58% in daylight;— evaluation of antioxidants UV absorbers and sequestering agents showed a significant protection against deterioration only by EDTA dipotassium salt;— ethanol was converted into acetaldehyde and its diethylacetal by peroxides present and formed on ageing up to 0.08%. Natural products accelerated this formation;— the reaction between benzoyl peroxide and ethanol was shown to yield up to 63% of acetaldehyde+diethyl acetal whilst di-t-butyl peroxide gave only 23% under the same conditions.These results go some way to explaining odour changes in perfume ageing.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Of 1609 individuals who were interviewed and asked whether they had experienced adverse reactions to cosmetics or toiletry products in the preceding 5 years, 196 (12.2%) claimed to have experienced some such reaction.Females (n= 124) mostly attributed their complaints to soap (41%), facial creams (33%), deodorant (25%), shampoo (16%) and eye shadow (11%). Men (n= 72) complained about adverse effects from soap (49%), aftershave (22%), deodorant (19%) and shower foam (12%). Both in women and in men, most reactions were localized on the face (60% resp. 33%), followed by the hands (19% resp. 21%) and the axillae (18% resp. 14%). The majority of patients could solve the problem by stopping the use of the suspected product and purchasing a different brand. Nevertheless, medical consultation was sought by more than 30% of all patients.Presumably, the majority of all adverse effects were caused by irritation; contact allergic reactions are infrequent.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: La xérose se traduit toujours en microscopie par un remaniement architectural de la couche cornée. Cette modification de structure peut être étudiée en détails en microscopie électronique à balayage où la xérose de l'individu âgé apparaît différente de la xérose induite par photochimiothérapie. L'examen en microscopic optique de biopsies de couche cornée, colorées à l'éosine, est cependant suffisant pour déterminer de façon précise le degré de xérose d'un épiderme.Par ces deux méthodes, le bénéfice de l'application de crèmes dites hydratantes a été apprécié. Les modifications induites par les crèmes testées portent davantage sur les couches profondes que sur les couches superficielles du stratum corneum. Ceci nous incline à penser que ces produits n'agissent qu'indirectement sur les structures inertes de l'épiderme. Xerosis: structure of rough skin
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: On a cherchéà mettreau point une méthode permettant d'apprécier l'aspect de la surface de la peau pour étudier les modifications du relief cutané provoquées par les expositions aux rayons ultra-violets et pour apprécier l'efficacité des produits cosmétiques protecteurs (produits solaires). Les méthodes des mesures in vivo utilisées classiquement sont basées sur une réaction rapide de la peau: l'érythème. La méthode décrite ici permet d'étudier un autre aspect: la surface de la peau.La technique opératoire consiste à faire une empreinte sur une zone de peau préalablement irradiée et une zone de peau témoin non-irradiée. On procède ensuite à un examen de macrophotographies de ces empreintes réalisées dans des conditions standardisés et reproductibles. On met en évidence une modification nette de l'aspect de surface de la peau après expositions aux rayons UV. Cette modification se traduit par une amplification du relief, un élargissement de la structure, une augmentation de la profondeur des ridules. Une direction privilégiée apparaît ou est accusée. L'étude descriptive de ces modifications a été réalisée sur plus de 200 sujets en utilisant un simulateur solaire ou après expositions au soleil.L'altération de la surface de la peau croît lorsque la dose d'energie reçue augmente. On a défini un seuil, la. MAD, dose minimum d'énergie nécessaire à l'apparition d'une altération après exposition unique. La cinétique du phénomène comporte trois phases: apparition, développement vers un maximum, retour à la normale.On observe également le développement du phénomène lorsque l'on procède à la superposition d'expositions plusieurs jours de suite avec, à chaque fois, une énergie voisine de la MED.On observe que l'altération du relief cutané peut se produire bien que la peau n'ait pas subi d'érythème.Cette méthode a été utilisée pour tester le pouvoir protecteur des produits cosmétiques filtrants. On a mis en évidence l'effet d'un filtre UV-B et d'un filtre UV-B + UV-A (spectre large).La méthode décrite ici permet donc d'appréhender avec une optique différente l'efficacité des produits solaires par des tests in vivo.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Protein denaturation was investigated to establish an in vitro evaluation method of surfactants in connection with their in vivo irritation potency to human skin. Eventually a new method with simplicity and high reproducibility was established by using quantitative analysis with gel-permeation chromatography (GPC). The protein denaturing potency of the commercially available surfactants was measured by using the developed method. Synergistic reduction in protein denaturation was observed in the mixed systems of anionic and amphoteric surfactants. The synergistic reduction was explained in terms of the physico-chemical properties of the mixed surfactants. A possible mechanism is the remarkable lowering of the total monomer concentration by the formation of hydrophobic complexes between the anionic and amphoteric surfactants. Relation entre les propriétés physico-chimiques des mélanges de surfactifs et leur potentiel de dénaturation des protéines
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A comparative study was conducted on the influence of widely used humectants [glycerol, propylene glycol (PG), polyethylene glycols 400 and 600 (PEG 400 and PEG 600)] on the physical characteristics of solidified sodium stearate-based sticks (SSSS).– Sticks prepared with PG or PEG 600 generally tended to be harder than the corresponding ones containing glycerol or PEG 400;– PG lowered the penetrability of the sticks while PEG 400 tended to increase it. Glycerol or PEG 600 produced sticks with intermediate penetrability values;– all investigated sticks showed practically acceptable softening points;– PG-based sticks showed the lowest yield by abrasion values while PEG 400-based ones showed the highest such values. Glycerol or PEG 600 produced sticks with intermediate behaviour;– sticks prepared with PG generally showed the highest tendency to dry by evaporation. There was a clear tendency towards reduction in evaporation with all the considered humectants, proportional to humectant concentration increase;– sticks formulated with PEGs showed considerably longer disintegration times than those formulated with glycerol or PG;– all sticks showed a plastic thixotropic flow behaviour;– static and dynamic yield value-humectant concentration curves exhibited an almost identical behaviour with all investigated systems;– generally speaking, SSSS with PG showed the highest dynamic and static yield values while those formulated with PEG 400 showed the lowest such values; the presence of PEG 400 or glycerol resulted in sticks with intermediate behaviour in this respect;– PG produced sticks showing the highest thixotropic breakdown by shear; glycerol came next in this respect. PEG-based sticks showed strong fluctuations in their thixotropic breakdown-humectant concentration behaviour;– PG gave sticks with the highest plastic viscosity; they, indeed, had a tough texture. Glycerol or PEG 600-based sticks had intermediate plastic viscosities and acceptable spreading characteristics. PEG 400-based sticks had the lowest plastic viscosity and best spreading characteristics;– almost all sticks investigated proved to be stable after 18 months storage as far as
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
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  • 10
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Wound healing involves the activity of epithelial cells and fibroblasts. This process is particularly accompanied by an increase in the proliferative capacity of the fibroblasts and by the biosynthesis of constitutive proteins of connective tissue. To study the action of wound healing drugs on the growth of fibroblasts, they were cultured in a medium containing a suboptimal concentration of serum. Several growth factors (eye-derived growth factor and fibroblast growth factor) were compared with various healing products for their effects on the growth curve. Some products slightly increased the proliferation of fibroblasts, in comparison with the optimal growth obtained with growth factors. Intérêt des fibroblastes en culture dans l'étude de produits cicatrisants
    Type of Medium: Electronic Resource
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