Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Abstract: OBJECTIVE: The aim of the study was to assess the longitudinal association between cardiovascular risk factors including albuminuria and other variables (e.g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years. METHODS: Nine thousand nine hundred and fifty-three participants of the ESTHER (Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen) study - a population-based cohort study of middle-aged and older adults aged 50-74 years at baseline - were recruited by general practitioners (GPs) in 2000-2002 and included in the follow-up (2005-2007). HRQOL at baseline and follow-up was measured using the Short-Form General Health Survey (SF-12). Mental component scores (MCS) and physical component scores (PCS) were calculated. Multiple linear regression models were used to determine longitudinal predictors of HRQOL at follow-up. RESULTS: Four thousand, two hundred and three patients with hypertension (98.2%) responded to the SF-12 both at baseline and after 5 years and were therefore included in the study. Smoking status, BMI, diabetes, macroalbuminuria, comorbid diseases, history of depression, and lower HRQOL at baseline predicted lower PCS at the 5-year follow-up. Lower MCS after 5 years was predicted by smoking status, dyslipidaemia, a reported history of depression, and HRQOL at baseline. No significant association was detected between awareness of hypertension and any HRQOL component score after 5 years. CONCLUSIONS: Macroalbuminuria and other variables related to increased cardiovascular risk have a negative impact on PCS. Suggestions of a link of treatment and awareness of hypertension with HRQOL from previous cross-sectional studies are not supported by our longitudinal findings.
    Type of Publication: Journal article published
    PubMed ID: 22573129
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Abstract: OBJECTIVE: Recent studies have unveiled cardiovascular pathological roles of mineralocorticoid receptor (MR) in many types of cells. Although we have confirmed high expression of MR in intestinal epithelial cells (IEC), that role in progression of cardiovascular diseases is yet to be elucidated. As intestine is the first gate sensing sodium intake, MR of this organ is expected to have essential roles in blood pressure (BP) regulation. This study investigated the role of MR in IEC by using IEC-specific MR knockout mice (IEC-MR KO). DESIGN AND METHOD: We generated IEC-MR KO with floxed MR and Villin Cre mice. We measured BP, body weight and urinary concentration of sodium and potassium. Using eluate of feces, fecal excretion of these electrolytes was also determined. After sacrifice, we quantitated expression level of various genes in intestine and kidney using real-time quantitative RT-PCR assay. Next, we examined the effect of high-salt diet (8% NaCl) and deoxycorticosterone acetate (DOCA)/1% NaCl treatment (1% NaCl solution to drink and DOCA pellet). RESULTS: MR expression of IEC-MR KO decreased by 90% throughout intestine. Compared with wild-type mice (WT), fecal sodium excretion of IEC-MR KO increased by 1.5 fold in accordance with decreased colonic expression of gammaENaC. Conversely, urinary sodium excretion was reduced by 30%. IEC-MR KO exhibited unaltered body weight and BP. DOCA/1% NaCl treatment but not high-salt diet raised BP in both groups. Interestingly, the effect on BP increase in IEC-MR KO was smaller than that of WT (WT: 123.0 +/- 9.0 mmHg, IEC-MR KO: 113.1 +/- 6.0 mmHg, P 〈 0.05). Elevated fecal sodium excretion and decreased urinary excretion in IEC-MR KO were also confirmed. CONCLUSIONS: MR in IEC regulates sodium absorption with modulating gammaENaC expression in colon. The effect of DOCA/1% NaCl treatment on BP was ameliorated with MR deletion from IEC. These studies reveal that intestinal epithelial MR has an important role in regulation of BP.
    Type of Publication: Journal article published
    PubMed ID: 27643161
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Abstract: OBJECTIVE: The aim of the study was to assess the association of hypertension and symptoms of depression and generalized anxiety in a large cohort of elderly people. METHODS: Data were derived from the 8-year follow-up (2008-2010) of the epidemiological ESTHER-cohort study. A total of 3124 randomly chosen participants aged 57-84 were visited at their homes by trained study doctors. General practitioner based diagnosis, self-reported status of hypertension, medication, and blood pressure measurement were considered to define the existence of hypertension. Depression and general anxiety severity were assessed using validated questionnaires. Logistic regression analyses were performed to determine cross-sectional associations between hypertension and clinically significant symptoms of depression (CSD) and generalized anxiety. Well known lifestyle risk factors for hypertension such as obesity were included in multivariate cross-sectional analyses. RESULTS: Hypertension was prevalent in 1659 participants [53.1%; 95% confidence interval (CI) = (51.3; 54.9)]. CSD was detected in 163 participants [5.2%; 95%-CI = (4.4; 6.0)]. Symptoms of generalized anxiety were found in 434 participants [13.9%; 95%-CI = (12.7; 15.1)]. Patients with CSD showed significantly higher odds of being hypertensive [odds ratio (OR) = 1.76; 95%-CI = (1.14; 2.74)]. Participants with symptoms of generalized anxiety were found to have no higher odds for a hypertension diagnosis [OR = 1.1; 95%-CI = (0.85; 1.44)]. Overweight [OR = 1.86; 95%-CI = (1.53; 2.25)] as well as obesity [OR = 3.58; 95%-CI = (2.84; 4.52)] was significantly associated with hypertension. CONCLUSION: CSD appear to be related to hypertension in elderly adults. No association was found between symptoms of generalized anxiety and hypertension.
    Type of Publication: Journal article published
    PubMed ID: 27341438
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
  • 5
    Keywords: brain ; PEPTIDE ; RECEPTOR ; EXPRESSION ; PROTECTION ; BLOOD ; Germany ; SYSTEM ; HEART ; MICE ; TIME ; RECEPTOR EXPRESSION ; INDEX ; animals ; CONTRAST ; treatment ; TYPE-1 ; WATER ; PERFORMANCE ; DESIGN ; FACTOR-KAPPA-B ; RECEPTORS ; DRINKING ; CARDIOVASCULAR-SYSTEM ; fibrosis ; DRINKING-WATER ; ANGIOTENSIN-II ; ARTERIAL-HYPERTENSION ; AT(1) ; AT(2) receptor knockout mouse ; CANINE LEFT-VENTRICLE ; CHRONIC INHIBITION ; confounding ; II TYPE-2 RECEPTOR ; L-NAME ; LONG-TERM BLOCKADE ; NITRIC-OXIDE SYNTHESIS ; PRESSURE-VOLUME RELATIONSHIPS ; ventricular hypertrophy
    Abstract: Background The role of angiotensin II type 1 (AT(1)) and type 2 (AT(2)) receptors in cardiac hypertrophy and fibrosis is incompletely understood. The availability of AT(2) receptor-deficient mice (AT(2) -/y) makes it possible to study the effects of AT, receptors without the confounding influence of AT(2) receptor activity. Objective To test the hypothesis that the AT(2) receptor affords protection from left ventricular hypertrophy and fibrosis in chronic hypertension induced by N-omega-nitro-L-arginine methyl ester (L-NAME). Design Four groups of mice were studied over a period of 3 weeks: AT(2) -/y mice with and without L-NAME, and AT(2) +/y mice with and without L-NAME. Methods Blood pressure and heart rate were monitored by telemetry in groups of AT(2) +/y and AT(2) -/y mice for 4 weeks. L-NAME groups received the compound in drinking water for the last 3 weeks. We determined left ventricular AT, receptor expression, cardiac hypertrophy and fibrosis, with and without L-NAME treatment. We used a miniaturized conductance-manometer system to measure pressure-volume loops at the time when the animals were killed. Results AT(2) -/y mice treated with L-NAME showed worse left ventricular hypertrophy, more perivascular fibrosis and greater concentrations of brain natriuretic peptide than did AT(2) +/y mice treated with L-NAME. The end-systolic pressure-volume relationship, an index of left ventricular contractility, was decreased in AT(2) -/y mice treated with L-NAME. Conclusions The AT(2) receptor is not essential for development of L-NAME-induced cardiac hypertrophy, fibrosis and concomitant changes in left ventricular performance. In contrast, the AT(2) receptor offers a protective effect. (C) 2004 Lippincott Williams Wilkins
    Type of Publication: Journal article published
    PubMed ID: 15097241
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...