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  • 1
    Abstract: PURPOSE: To evaluate whether quantitative characterization of aortic arch geometry including its branches is feasible based on in vivo computed tomography (CT) angiography and magnetic resonance (MR) angiography data in healthy and diseased aortic arches. MATERIALS AND METHODS: Ten healthy volunteers, 10 patients with abdominal aortic disease, and 10 patients with aortic arch disease underwent MR angiography (10 volunteers) or CT angiography (20 patients). Commercial software was used for individual segmentation of supraaortic arteries. In-house software was developed for segmentation of aortic arch landmarks based on standardized multiplanar reformations (MPRs) and for subsequent aortic arch mapping. RESULTS: Supraaortic arteries and aortic arch landmarks were successfully segmented in all 30 subjects for CT angiography and MR angiography data. Significant tapering within the first centimeter was observed in all supraaortic arteries (P 〈 .001). The three supraaortic arteries showed significantly different vessel diameters and areas (P 〈 .001). The software developed in-house allowed detailed aortic arch mapping with quantitative definitions of the positional relationships between each supraaortic artery and the aorta. Distances between supraaortic arteries were less than 5 mm in 77.6% (mean 4.1 mm +/- 3.8). The brachiocephalic trunk tended to be positioned on the right side of the aortic arch, and the left subclavian and left common carotid arteries tended to be positioned on the left side of the aortic arch. CONCLUSIONS: The feasibility and application of a postprocessing method allowing quantification of geometry of supraaortic arteries and aortic arch mapping were successfully demonstrated. Validation and evaluation of clinical implications are warranted
    Type of Publication: Journal article published
    PubMed ID: 21459612
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  • 2
    Abstract: PURPOSE: To determine the effect of tissue perfusion on microwave ablation lesions in an experimental in vivo study in porcine kidneys. MATERIALS AND METHODS: Twelve kidneys of six pigs were studied. In each animal, two microwave ablations were created in one kidney without limitation of tissue perfusion (group 1). In the other kidney, two microwave ablations were performed with interruption of blood flow (group 2). All microwave ablations were performed with identical system parameters (eg, temperature control mode, ablation time of 80 s, and temperature of 110 degrees C). The animals were euthanized 3 hours later. The kidneys were harvested and cut into 2-3-mm transverse slices. Microwave ablation zone dimensions (eg, length, width, and volume) and shape (eg, sphericity ratio) and corresponding variability were compared between groups. RESULTS: Microwave ablation areas were significantly longer (41.6 mm +/- 4.0 vs 34.2 mm +/- 5.9; P 〈 .01) and wider (16.6 mm +/- 1.2 vs 12.2 mm +/- 2.1; P 〈 .001) in group 2 than in group 1. Similarly, microwave ablation volume was significantly greater in group 2 compared with group 1 (6.7 cm(3) +/- 1.0 vs 3.3 cm(3) +/- 1.2; P 〈 .001). Ablation area shapes were similar between groups (sphericity ratio, 2.57 +/- 0.42 vs 2.39 +/- 0.34). Ablation area variabilities were also comparable between groups (volume variance of 1.32 vs 0.93; sphericity ratio variance of 0.18 vs 0.11). CONCLUSIONS: After interruption of blood flow, microwave ablation areas are significantly larger than those achieved without limitation of tissue perfusion. Microwave ablation area shape and variability were comparable between study groups.
    Type of Publication: Journal article published
    PubMed ID: 21982204
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