Amino acid sequence
Springer Online Journal Archives 1860-2000
Summary We found two types of hemoglobin, T and R, from the crab-eating macaque and compared those to A and Q previously reported. The 22 animals studied showed six different phenotypes, A, R, QA, QT, QAT, and QAR. Analysis of the complete amino acid sequences for the α chains of hemoglobins Q, A, T, and R revealed that amino acids at four positions, 8, 55, 71, and 78 from the N-terminal, are variable. In the αA chain, Thr, Val, Gly, and Gln occupy these positions, and in the αQ chain the analogous amino acids are Thr, Val, Asp, and Gln, respectively. In the newly found αT chain they are Thr, Val, Gly, and His; and in the αR chain, they are Ser, Ile, Gly, and His, respectively. Two amino acids (α8 Thr and α79 Gln) in αA of the crab-eating macaque were found to be different from those in the α chain of the Japanese macaque.
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