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  • 1
    Keywords: Enzyme Activation ; GTP Phosphohydrolase-Linked Elongation Factors/*chemistry/*metabolism ; GTP Phosphohydrolases/*chemistry/*metabolism ; Guanosine Triphosphate/metabolism ; *Protein Biosynthesis ; Ribosomes/metabolism
    Abstract: Protein biosynthesis is a complex biochemical process. It integrates multiple steps where different translation factors specifically interact with the ribosome in a precisely defined order. Among the translation factors one can find multiple GTP-binding or G-proteins. Their functioning is accompanied by GTP hydrolysis to the GDP and inorganic phosphate ion Pi. Ribosome stimulates the GTPase activity of the translation factors, thus playing a role analogues to GTPase-activating proteins (GAP). Translation factors--GTPases interact with the ribosome at all stages of protein biosynthesis. Initiation factor 2 (IF2) catalyse initiator tRNA binding to the ribosomal P-site and subsequent subunit joining. Elongation factor Tu (EF-Tu) is responsible for the aminoacyl-tRNA binding to the ribosomal A-site, while elongation factor G (EF-G) catalyses translocation of mRNA in the ribosome by one codon, accompanied by tRNA movement between the binding sites. In its turn, release factor 3 (RF3) catalyse dissociation of the ribosomal complex with release factors 1 or 2 (RF1 or RF2) following the peptide release. This review is devoted to the functional peculiarities of translational GTPases as related to other G-proteins. Particularly, to the putative GTPase activation mechanism, structure and functional cycles.
    Type of Publication: Journal article published
    PubMed ID: 16240709
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  • 2
    Abstract: This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangement in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from molecular mechanistic and biological point of view. In addition to classical problems of this field, actual questions of epigenetic regulation are mentioned. The authors selected for discussion what seem to be the most interesting concepts and hypotheses. Mathematical approaches are described in a simplified language to attract attention to the most important directions of this field.
    Type of Publication: Journal article published
    PubMed ID: 22642097
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