Primary myocardial disease
Springer Online Journal Archives 1860-2000
Summary Right and left ventricular (RV, LV) function were evaluated by quantitative bi-plane cineangiocardiography in 20 patients, aged 1 day to 6 years, who had primary myocardial disease presenting with heart failure. RV end-diastolic volume (RVEDV) was 157%±63% ( $$\bar X$$ ±SD) of normal (P〈.01), and RV ejection fraction (EF) was 0.39±0.16 (normal, 0.65±0.08) (P〈.01). Left Ventricular end-diastolic volume (LVEDV) was 331%±172% of normal and LVEF 0.26±0.12 (normal, 0.68±0.05); both values were different from normal (P〈.01) and also different from corresponding RV values (P〈.01). RVEDV was larger than LVEDV in only four patients, these four patients being the youngest patients in the entire group, all 10 days of age or younger. A subgroup of 14 patients with subnormal RVEF (RVEF〉 $$\bar X$$ −2 SDs of normal) were compared with six patients with normal RVEF. Patients with subnormal RVEF had larger left ventricles, lower LVEFs, and higher RV peak systolic pressure than those with normal RVEF (P〈.05 for all three comparisons). A separate subgroup of ten patients who died was compared with a subgroup of eight surviving patients followed up for one to four years after diagnosis. Patients who died had lower values for LVEF and LV systolic output and higher values for LV end-diastolic pressure than did survivors. There were no significant differences between patients who died and survivors in any of the RV variables measured. RV functional abnormalities were generally present in both infants and children who had myocardial disease presenting with heart failure and may especially contribute to the symptoms in infants.
Type of Medium: