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  • 1
    Keywords: antibodies, ANTIGEN, BODIES, COMBINATION, COMPLEX, cryoglobulinaemia, DIAGNOSIS, DISEASE, DISEASES,
    Abstract: We describe the case of a 78-year-old woman with peripheral neuropathy, neurogenic muscular atrophy, skin ulcers, arthritis and immune complex glomerulonephritis. Detection of mixed cryoglobulins in combination with typical clinical symptoms, and the exclusion of hepatitis C and other underlying diseases, led to the rare diagnosis of essential cryoglobulinaemic vasculitis type III. Because initial interventions with prednisolone, plasmapheresis and cyclophosphamide pulse therapy failed to induce remission, therapy with rituximab, a chimeric monoclonal antibody that reacts specifically with the CD20 antigen, was initiated. Rituximab was administered intravenously at a dose of 375 mg/m(2) body surface. After five applications, the patient showed remission of clinical symptoms and complete normalisation of laboratory values. These results suggest that rituximab is an alternative therapeutical approach with strikingly good clinical outcome in patients with cryoglobulinaemic vasculitis type III
    Type of Publication: Journal article published
    PubMed ID: 17924113
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  • 2
    Keywords: ANGIOGENESIS ; CELLS ; EXPRESSION ; GROWTH ; IN-VITRO ; COMBINATION ; ENDOTHELIAL GROWTH-FACTOR ; Germany ; IN-VIVO ; INHIBITION ; MODEL ; MODELS ; VITRO ; MONOCLONAL-ANTIBODY ; MICE ; PATIENT ; ARTHRITIS ; MECHANISM ; ASSAY ; NECROSIS-FACTOR-ALPHA ; STRATEGIES ; FUSION PROTEIN ; METHOTREXATE ; COLLAGEN-INDUCED ARTHRITIS ; ANIMAL-MODELS ; endothelial cells ; rheumatoid arthritis ; RHEUMATOID-ARTHRITIS ; LOW-DOSE METHOTREXATE ; RHEUMATOID-ARTHRITIS PATIENTS ; HUMAN PLACENTA ; ANIMAL-MODEL ; ANTIANGIOGENIC ACTIVITY
    Abstract: Objectives: The aim of this study was to investigate whether methotrexate (MTX) has an anti-angiogenic effect and whether this property plays a role in the control of rheumatoid arthritis (RA). Methods: A human placenta angiogenesis assay was used to examine the antiangiogenic effects of MTX in vitro. In addition, DBA/1 mice were used to compare the antiarthritic effect of MTX in collagen-induced arthritis (CIA) and its antiangiogenic effect in a murine in vivo matrigel model for angiogenesis. Results: The spreading of microvessels from placental vessel fragments was not significantly inhibited by MTX. Treatment with MTX reduced significantly the incidence of CIA in DBA/1 mice in a dose-dependent manner. However, treatment with the same doses of MTX did not significantly reduce vessel growth in subcutaneous depots of bFGF-enriched matrigel. Conclusion: These data support the hypothesis that inhibition of angiogenesis does not significantly contribute to the antiarthritic effect of MTX seen in patients and animal models for RA. Therefore, the combination of MTX with antiangiogenic drugs appears to be a rational strategy in the treatment of RA
    Type of Publication: Journal article published
    PubMed ID: 14618373
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  • 3
    ISSN: 1437-160X
    Keywords: Spontaneous and induced immunoglobulin production ; Leukocyte subsets ; Immunohistology ; Wegener's granulomatosis ; Autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a reverse plaque forming cell (PFC) assay the production of immunoglobulin (Ig) by peripheral blood mononuclear cells (MNCs) in vitro was studied in 12 patients with Wegener's granulomatosis (WG). Spontaneous IgG production was increased in two of six untreated patients. The IgG response of MNCs from eight untreated patients to pokeweed mitogen (PWM) and Epstein-Barr virus (EBV) stimulation was significantly depressed. The IgM and IgA production followed the individual pattern of IgG. Blood B-cell and T-cell subset concentrations were normal before therapy, whereas the monocyte concentration was increased in four of six patients. Titers of anti-neutrophil cytoplasm autoantibodies (ANCAs) did not correlate with spontaneous or induced Ig production nor with blood leukocyte subset concentrations. Biopsy specimens from upper respiratory tract lesions in seven untreated patients showed numerous macrophages, activated T lymphocytes, and plasma cells, suggesting a pathogenetic role of these cells in the development of lesions and local production of ANCAs.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-160X
    Keywords: Gold sodium thiomalate ; Fc-receptors ; Complement receptors ; Adjuvant polyarthritis rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the effect of chrysotherapy on the Fc and complement receptor binding activity of peripheral blood (PB) monocytes and peritoneal (PE) macrophages isolated from normal rats and rats with adjuvant induced arthritis. The adjuvant induced severe disease in Dark Agouti (DA) rats and less marked disease in J. C. Lewis (JC) rats. Gold treatment reduced the disease in DA rats but exacerbated the disease in JC rats. PB monocytes generally exhibited increased receptor activity after adjuvant injection. Gold treatment resulted in a simultaneous reduction of the PB monocyte receptor activity and increased the PE macrophage receptor activity. This was considered to be due to a direct effect of gold, since the Fc receptor activity of PE macrophages increased after in vitro gold treatment.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Anti-lymphocyte autoantibodies ; Shedding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Shedding of cell-surface antigens that react with anti-lymphocyte autoantibodies in systemic lupus erythematosus (SLE) is well-recognized, but the nature of such molecules is unknown. The present investigation demonstrates the rapid shedding of three IgG antibody target molecules of Mr 55 000, 37 000, and ∼32 000 from the surface of mitogen-activated peripheral T cells during brief incubation at 37°C. Sera lacking IgG anti-lymphocyte antibodies stained none of the three antigens. Absorption of antibody-positive sera with viable HSB-2 cells, a primitive T-cell line lacking HLA antigens and many CD antigens characteristic of mature peripheral T cells, eliminated staining of the shed molecules. These data delineate the number and estimated molecular mass of anti-lymphocyte autoantibody target molecules that are shed from the surface of T cells, and provide further insight into potential mechanisms by which anti-lymphocyte antibodies contribute to the pathogenesis of SLE and related disorders.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1437-160X
    Keywords: Ultrastructure ; Synovium ; Macrophages ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The morphological type B cells were found to express none of these antigens. The findings are consistent with the idea that the synovial lining comprises two cell types, bone-marrow derived macrophages and mesenchymal fibroblasts.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 8 (1988), S. 188-188 
    ISSN: 1437-160X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1437-160X
    Keywords: Lupus ; SLE ; Therapy ; Nephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prognosis of systemic lupus erythematosus has improved markedly. This has been due to various factors: improved serological testing leading to better diagnosis, better understanding of secondary complications, and the possibility of treating these. How much has improved treatment of the primary disease process contributed to the improvement in prognosis? We have evaluated the clinical outcome of 56 patients with lupus nephritis proven by biopsy, followed at out hospital over the past 16 years. During this period various therapies were used during active periods of the disease, based on literature data or participation in trials. Prognostic risk factors for the development of end stage renal disease (ESRD) appeared to be: WHO-class IV histopathology of the renal biopsies, male sex and raised serum creatinine. Development of ESRD at 5 years was 13% and at 10 years was 30%. Overall survival was 95%. Based on data from well controlled trials performed at the National Institute of Health (US) and our observations the need for well conducted long-term prospective randomized trials is stressed again.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 11 (1991), S. 151-155 
    ISSN: 1437-160X
    Keywords: Synovium ; Lymphatics ; Rheumatoid arthritis ; PAL-E ; Ulex europaeus agglutinin I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a cocktail of monoclonal antibodies PAL-E and DE-U-10 (anti-desmin), combined in double labelling techniques with the lectin Ulex europaeus agglutinin I (UEAI), vessels consistent with lymphatics were demonstrated in normal human synovial tissue. These vessels were negative for the monoclonal cocktail and positive for UEAI, were thin-walled and were located close to deep arterioles and venules as expected. Elastin was not found to assist identification of lymphatics in synovium. In rheumatoid arthritic synovium no vessels staining in the manner of normal lymphatics were found. This may indicate absence or change of phenotype of this type of endothelium in disease.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1437-160X
    Keywords: Intravenous regional administration ; Corticosteroid ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intravenous regional administration of corticosteroid (IVRAS) in the treatment of rheumatoid arthritis of the hand has not been reported previously. The method is based on a modification of Bier's block, with substitution of corticosteroid for local anaesthetic. Twenty-two patients were assessed in this double-blind, placebo-controlled study. The technique was safe and effective in improving grip strength, with a group mean improvement of more than 50%. Because suppression of endogenous cortisol production 24 h after treatment was commensurate with the dose of methylprednisolone used (40 mg), we could not exclude that the response may have been due to systemic steroid. Further studies are required to define the real value of IVRAS as it may offer alternative treatment of the joints and tendons within the hand and wrist in some patients rather than more prolonged oral therapy or individual, multiple joint or sheath injections.
    Type of Medium: Electronic Resource
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