Springer Online Journal Archives 1860-2000
Summary The new biventricular cardiac assister designed to compress selectively both ventricles of the brain-death dog was evaluated. The parameters determined in the present investigation were cardiac output, aortic pressure, pulmonary arterial pressure, blood gases, blood pH, serum glucose and body temperature. In the brain-death dogs, the cardiac output and the aortic pressure were kept relatively well, but the blood pressure was about 20 per cent lower than that of the non brain-death dogs with ventricular fibrillation, in which blood supply to the brain was intact and EEG was normal. The pulmonary hypertension was not noted, but various changes in blood pH, blood gases, serum glucose and body temperature may have been due to absence of brain function. The lung, heart, liver and kidney can be preserved in situ under mechanical cardiac massage with the use of our new cardiac assister, set in thorax of the brain-death dogs after cardiac arrest. In cases where organ preservation was done at room temperature, each organ can be kept for 6–8 hours in good condition for organ transplantation. But thereafter hypoxic changes were noted in these organs, particularly in liver and kidney, but less in lung and heart. The usefulness of our new cardiac assister for preservation of liver and kidney is at the present time limited to 6 to 8 hours and that for lung preservation is limited to 12 hours at room temperature.
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