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  • 1
    Keywords: measurement ; CANCER ; MODEL ; MODELS ; PROSTATE ; FOLLOW-UP ; SUPPORT ; POPULATION ; RISK ; RISKS ; METABOLISM ; PATIENT ; MARKER ; INDEX ; ASSOCIATION ; resistance ; PLASMA ; OBESITY ; prostate cancer ; PROSTATE-CANCER ; MARKERS ; cancer risk ; PARAMETERS ; UNITED-STATES ; GLUCOSE ; BODY ; SERUM LEVELS ; RELATIVE RISK ; leptin ; insulin ; MASS INDEX ; MASSES ; BODIES ; REGRESSION ; ASSOCIATIONS ; aging ; prospective studies ; 4.0 NG/ML ; BODY-SIZE ; fat distribution ; PHYSICAL-ACTIVITY ; PLASMA-GLUCOSE
    Abstract: Objectives. To examine the relationship of insulin, glucose, and anthropometry with the subsequent risk of prostate cancer. Methods. The relative risk of prostate cancer by insulin, glucose, and anthropometric measures was evaluated in 823 male participants (87 patients with prostate cancer in 10,737 person-years of follow-up) of the Baltimore Longitudinal Study of Aging who had at least one fasting plasma insulin measurement, which was prediagnostic for those with prostate cancer. Age-adjusted and multivariate-adjusted relative risks were estimated from Cox proportional hazards regression models. Results. Insulin concentrations were in the normal range (defined as less than 20 muU/mL) for 95.1% of participants. Fasting insulin and glucose levels were unrelated to prostate cancer risk in our overall analysis (P for trend = 0.56 and 0.45, respectively). The relative risk of prostate cancer for the second through fourth quartiles of the waist/hip ratio compared with the lowest quartile was 2.10, 1.96, and 2.06, respectively (P for trend = 0.32). Risk was unrelated to waist circumference and body mass index. Conclusions. The results of this study do not conclusively support positive associations of markers of insulin and glucose metabolism and obesity with prostate cancer. Additional larger prospective studies with repeated measure of these parameters are warranted to explore these associations further
    Type of Publication: Journal article published
    PubMed ID: 14972466
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  • 2
    Keywords: SPECTRA ; Germany ; human ; TOOL ; PROTEIN ; DIFFERENTIATION ; PATIENT ; BIOMARKERS ; IDENTIFICATION ; ARRAYS ; mass spectrometry ; MASS-SPECTROMETRY ; PREDICTION ; sensitivity ; specificity ; CELL CARCINOMA ; ALLOGRAFT-REJECTION ; TECHNOLOGY ; RELEVANCE
    Abstract: Objectives. To develop a noninvasive method for the detection of renal transplant rejection using ProteinChip Arrays (surface-enhanced laser desorption/ionization time-of-flight mass spectrometry). Methods. A total of 23 urine samples were collected from 13 patients showing biopsy-proven renal allograft rejection and from 10 patients without histologic signs of rejection. All 23 patients had clinical symptoms and signs of acute allograft rejection and underwent renal biopsy. Samples were centrifuged, and supernatants were directly spotted onto the ProteinChip arrays with different chromatographic surfaces. The obtained spectra in a range from 2 to 200 kDa were subjected to bioinformatic analysis using the method of Fuzzy c-means, followed by the establishment of rule bases and evaluation using the relevance index according to Kiendl. Results. Several protein peaks were identified allowing differentiation between rejection and no rejection. Using two different ProteinChip surfaces, we found two biomarkers at 25.71 kDa and 28.13 kDa that gave a diagnostic sensitivity of 90% and 93% and a specificity of 80% [SAX2) and 85% (CM 10), respectively. Conclusions. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry appears to be a promising new diagnostic tool for distinguishing renal transplant patients with no rejection from those with acute rejection
    Type of Publication: Journal article published
    PubMed ID: 16527560
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  • 3
    Keywords: CANCER ; CELLS ; PROSTATE ; FOLLOW-UP ; INFORMATION ; COHORT ; DEATH ; incidence ; MORTALITY ; NEW-YORK ; RISK ; ASSOCIATION ; HEALTH ; AGE ; CIGARETTE-SMOKING ; MEN ; smoking ; prostate cancer ; PROSTATE-CANCER ; US ; UNITED-STATES ; ADULT ; REGRESSION ; review ; ASSOCIATIONS ; INTERVAL ; analysis ; methods ; USA ; CANCER INCIDENCE ; prospective ; CANCER-MORTALITY ; DEATHS ; TOBACCO USE
    Abstract: OBJECTIVES To examine the association of cigarette smoking with subsequent fatal prostate cancer. METHODS Two private censuses were conducted in Washington County, Maryland, in which 26,810 adult men in 1963 and 28,292 in 1975 provided smoking information. Prostate cancer deaths through 2000 (1963 cohort, 240 deaths; and 1975 cohort, 184 deaths) were ascertained by review of the death certificates. Poisson regression analysis was used to estimate the rate ratio of prostate cancer death adjusted for age. RESULTS Overall, cigarette smokers in the 1963 census cohort were not more likely to die of prostate cancer than those who had never smoked cigarettes, pipes, or cigars when considering the total follow-up period. However, current smokers of 20 or more cigarettes per day (rate ratio 2.38; 95% confidence interval 0.94 to 5.99) and former smokers (rate ratio 2.75; 95% confidence interval 1.13 to 6.74) had a greater risk of death from prostate cancer during the first 10 years of follow-up. Weaker positive associations of prostate cancer death with current and former cigarette smoking were seen during the first 10 years of follow-up in the 1975 census cohort. Current cigarette smoking at baseline was not associated with the prostate cancer incidence. CONCLUSIONS The lack of an association between cigarette smoking and prostate cancer incidence, but the tendency of greater prostate cancer mortality in former and current cigarette smokers earlier in the follow-up period is consistent with other studies in which smoking was assessed once at baseline
    Type of Publication: Journal article published
    PubMed ID: 17445658
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  • 4
    Keywords: MODEL ; MODELS ; PROSTATE ; VOLUME ; NEW-YORK ; RISK ; SURGERY ; SERA ; RISK-FACTORS ; BINDING ; ASSOCIATION ; NO ; hormone ; HEALTH ; AGE ; CIGARETTE-SMOKING ; MEN ; smoking ; MULTIVARIATE ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; nutrition ; ESTRADIOL ; REGRESSION-MODELS ; METABOLITE ; physical activity ; albumin ; SERUM ; REGRESSION ; ASSOCIATIONS ; WEIGHT ; PHYSICAL-ACTIVITY ; BENIGN PROSTATIC HYPERPLASIA ; ESTROGEN ; INTERVAL ; methods ; PHASE ; USA ; HORMONES ; TESTOSTERONE ; NHANES III ; lower urinary tract symptoms ; STEROID-HORMONES ; EVALUATE ; INCREASED RISK ; odds ratio ; AMERICAN MEN ; LOGISTIC-REGRESSION ; HORMONE-BINDING-GLOBULIN ; SHBG ; sex ; ANDROSTANEDIOL GLUCURONIDE ; DIHYDROTESTOSTERONE ; FINASTERIDE ; FREE TESTOSTERONE
    Abstract: OBJECTIVES To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS). METHODS We included 260 men, 60 years old or older, who participated in Phase 1 (1988 to 1991) of the Third National Health and Nutrition Examination Survey and for whom surplus serum was available. We measured the serum concentrations of testosterone, androstanediol glucuronide (AAG), estradiol, and SHBG. Free testosterone was calculated from the circulating testosterone, SHBG, and albumin. The cases (n = 128) were men with two to four symptoms (nocturia, hesitancy, incomplete emptying, and weak stream), but who had never undergone noncancer prostate surgery. The controls (n = 132) were men who neither had symptoms nor had undergone noncancer prostate surgery. We adjusted for age, race/ethnicity, waist circumference, cigarette smoking, alcohol consumption, and physical activity in logistic regression models and used sampling weights. RESULTS The cases had statistically significantly greater AAG and estradiol concentrations than did the controls. After multivariate adjustment, the men in the top tertile of AAG (odds ratio 2.62, 95% confidence interval 1.12 to 6.14) had a greater risk of LUTS compared with men in the bottom two tertiles. Also, men with a greater estradiol concentration (odds ratio 1.78, 95% confidence interval 0.91 to 3.49) and a greater estradiol/SHBG molar ratio (odds ratio 2.41, 95% confidence interval 1.39 to 4.17) had a greater risk of LUTS than did men with lower concentrations. No consistent associations were seen for circulating testosterone, free testosterone, or SHBG. CONCLUSIONS In this cross-sectional study representative of older U.S. men, circulating AAG, a metabolite of dihydrotestosterone, and estradiol were associated with an increased risk of having LUTS
    Type of Publication: Journal article published
    PubMed ID: 17445656
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  • 7
    Keywords: CANCER ; MODEL ; MODELS ; PROSTATE ; SURGERY ; SERA ; ASSOCIATION ; HEALTH ; PLASMA ; AGE ; CIGARETTE-SMOKING ; MEN ; smoking ; prostate cancer ; PROSTATE-CANCER ; cancer risk ; DAMAGE ; TRACT ; nutrition ; SMOKERS ; VITAMIN-E ; SELENIUM ; carotenoids ; LYCOPENE ; RETINOL ; SERUM CONCENTRATIONS ; SERUM ; REGRESSION ; ASSOCIATIONS ; WEIGHT ; SUPPLEMENTATION ; SERUM MICRONUTRIENTS ; VITAMIN-A ; urinary tract ; BENIGN PROSTATIC HYPERPLASIA ; SELENIUM LEVEL ; TOCOPHEROL ; TOMATO
    Abstract: Objectives. To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS). Methods. We included 2497 men, 60 years old and older, who participated in the Third National Health and Nutrition Examination Survey from 1988 to 1994 and for whom serum concentrations of vitamins A, C, and E, carotenoids, and selenium had been measured previously. Cases were men with three or four of the following symptoms: nocturia, hesitancy, incomplete emptying, and weak stream, but who had never undergone noncancer prostate surgery. Controls were men without symptoms, who had never undergone noncancer prostate surgery. We adjusted for age and race in logistic regression models and used sampling weights. Results. Serum concentrations of vitamin E (P = 0.03), lycopene (P = 0.06), and selenium (P = 0.03) were lower in men with LUTS compared with controls. Men in the top four quintiles of vitamin E, lycopene, and selenium had a nonstatistically significant 25% to 50% reduced odds of LUTS compared with men in the bottom quintile. Inverse associations were not seen for the other carotenoids or vitamin A, A high serum vitamin C concentration was associated with a lower odds of LUTS in current smokers, but with a nonstatistically significant greater odds in those who never smoked and in former smokers. Conclusions. Greater circulating concentrations of vitamin E, lycopene, and selenium, antioxidant micronutrients that are supported in published reports as protecting against prostate cancer, were observed also to be inversely associated with LUTS. The effect modification of the association with vitamin C by cigarette smoking warrants additional examination
    Type of Publication: Journal article published
    PubMed ID: 15351580
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  • 8
    Keywords: BLADDER ; CHILDHOOD ; INTERGROUP RHABDOMYOSARCOMA ; PELVIC RHABDOMYOSARCOMA
    Abstract: Rhabdomyosarcomas are the most common soft tissue sarcomas in children. Here we present management of an 18-month-old boy with metastatic rhabdomyosarcoma of the bladder/prostate. After radiochemotherapy, high-spatial-resolution 3-Tesla multiparametric magnetic resonance imaging (MRI) showed regressive systemic disease but a residual mass at the right seminal vesicle. For histologic re-evaluation, 3-dimensional-controlled stereotactic MRI/transrectal ultrasound (TRUS)-fusion biopsy specimens were taken. Because histologic analysis showed nonvital tissue, a decision could be made against adjuvant radical cystoprostatectomy. Advanced 3-Tesla imaging and MRI/TRUS-fusion biopsies in children are feasible and represent an effective tool to examine suspicious pelvic lesions. Depending on histology, this can lead to a significant reduction of therapy-associated morbidity.
    Type of Publication: Journal article published
    PubMed ID: 23374821
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