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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of urology 1 (1983), S. 1-1 
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    World journal of urology 1 (1983), S. 29-35 
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transurethral resection in prostatic carcinoma as a possible cause of dissemination of tumor cells and consequently of accelerated metastatic growth has been a matter of discussion for years. In order to determine whether transurethral resection plays a role in the dissemination of prostatic cancer the following retrospective study was performed. Forty patients with prostatic carcinoma stage C who underwent palliative transurethral resection were compared with 12 patients without transurethral resection. Both groups of patients were compared in regard to survival rate, formation of bone and soft tissue metastases as well as to the increase in acid phosphatase and the development of supravesical urinary tract obstruction. As regards the frequency distribution for age at the time of diagnosis there was no difference between the two groups of patients. Regarding the survival rate there is no statistically significant difference between patients who undervent transurethral resection and those who did not. Data on the progression to stage D disease show no statistically significant difference between two groups of patients; therefore transurethral resection in prostatic carcinoma is not the cause of accelerated metastatic growth.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a study involving 174 patients with proven carcinoma of the prostate the significance of steroid measurements in circulating blood, prostatic tissues and urine in relation to clinical management of patients was evaluated and the following findings were obtained: 1. Despite certain differences in the serum level of individual androgens between normal and malignant patients, single measurements of androgens does not provide a reliable index for differentiating the normal subjects from patients with carcinoma of the prostate. However, the ratio of testosterone (T) to either 5α-dihydrotestosterone (DHT) or 5α-androstane-3α, 17β-diol (diol) can provide a better discriminant. 2. Assessment of changes in serum T and DHT following endocrine therapy of 158 patients with carcinoma of the prostate showed that with the exception of radiotherapy a highly significant suppression of these androgens were found following orchidectomy, treatment with diethylstilboestrol (DES), estramustinephosphate (Estracyt) and cyproterone acetate. The latter compound produced the least suppression of T compared to the other endocrine modalities. Estracyt produced similar degrees of suppression of DHT as Cyproterone acetate, but less than either orchidectomy or DES. 3. The measurement of steroids in prostatic tissues provides a more reliable index for separating malignant from benign hypertrophied tissues. Androstenedione, oestradiol-17β and T were found to be significantly higher in malignant prostates, whilst DHT was higher in benign hypertrophied tissues. 4. Urinary measurements of unconjugated steroids proved to be the least effective means in assessing the endocrine status in patients with malignant prostates.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    World journal of urology 1 (1983), S. 69-69 
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Complications and morbidity following radical prostatectomy for localized carcinoma of the prostate were analyzed in a series of 100 patients, using the perineal approach in 29 cases and the retropubic in 71 cases. The mortality rate was 1%. Rectal injuries in 6 patients and ureteral transsection in 2 patients accounted for intraoperative complications. The average amount of blood substituted in this series was 3,5 units per patient. Severe complications which occured in the early postoperative period were non-fatal myocardial infarction and pulmonary embolism in 6 patients. Persistent total urinary incontinence was found in 4 patients and stress incontinence of varying degree was recorded in 24 patients. Additional late complications were bladder neck contracture in 22 and urethral stricture in 5 patients. The rate of early and late complications after radical prostatectomy in this series compares satisfactorily with the average results reported in the literature.
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  • 7
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Topical chemoprophylaxis with adriamycin was administered to 49 patients with UICC-stages pTA and PT1 (pathological stage 0 and A) of transitional cell carcinoma of the urinary bladder. Tumor specimens obtained prior to initiation of the instillation protocol were evaluated with regard to ABH-antigenicity. ABH-antigens were present in tumors of 19 patients and none of these developed muscle-infiltrating recurrences during or after intravesical chemoprophylaxis. The primary lesions of 30 patients were deleted of antigens; only 5 (16%) developed a progressive recurrence. Compared to a historical control group this is thought to be a true reduction of invasive tumor recurrences in ABH-negative tumors by adriamycin. We herein propose that ABH-antigenicity may serve as a valuable prescreening indicator for or against topical chemoprophylaxis.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    World journal of urology 1 (1983), S. 2-2 
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As with many diseases the best chance for cure comes with early detection but unfortunately, surgically curable carcinoma of the prostate is found in only 5–15% of all patients. Clearly the largest obstacle to increasing survival is the early detection of the disease. Transrectal ultrasound provides another modality by which small lesions of the prostate can be identified. Its major drawbacks are the identification of diffusely involved carcinomas where no tissue interface exists and the inability to clearly separate areas of inflammation, stone and carcinoma. With further experience and inevitable improvement in instrumentation, perhaps these inadequacies will be resolved.
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  • 10
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective study of 55 patients with incidental prostatic carcinoma with long term follow-up is presented. All patients were treated with total perineal prostatectomy, 43 received some form of endocrine treatment after the initial diagnosis was made. In order to contribute to the establishment of low and high risk groups which do not or do require agressive treatment, a careful histological analysis of the 39 patients was carried out on whom total prostatectomy slides with tumor were available. The amount of tumor, grade and parameters commonly used to establish grading were determined and correlated with corrected survival. The findings indicate that a small amount of tumor, grade 1, the presence of small, intermediate or large glands (but not cribriform and/or solid tumor) and the presence of slight but not moderate or marked variation in size and shape of the nucleus are strong predictors of not dying from prostatic carcinoma. There is agreement with the literature, where similar groups of patients not further treated after the initial diagnosis had been established showed a comparably low number of progressions. It is concluded that small, well differentiated prostatic carcinomas (category T0pT1NxM0G1, stage A1) do not require an aggressive diagnostic work-up or further treatment. A group of 11 patients (27%) showed more extensive but well differentiated tumors. Only two of these patients died of prostatic carcinoma. The natural history of this entity is not sufficiently known to make definite treatment decisions. Staging, radical prostatectomy, radiotherapy or deferred treatment may be indicated. Grade 3 carcinoma or the presence of cribriform and/or solid tumor were strong predictors of progression and death from prostatic carcinoma. Seven of 14 patients with these characteristics died of their disease. It is concluded that at least the experience in this series does not show radical prostatectomy to be an optimal treatment in this group of patients. Smaller rates of progression are however described in the literature. Endocrine management does not seem to have any beneficial effect, reports on radiotherapy are scarce. The optimal treatment for this group of patients with a high risk of dying from their tumor and a significantly shortened overall survival is not known.
    Type of Medium: Electronic Resource
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