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  • 1
    Electronic Resource
    Electronic Resource
    A measurement of τ polarization in Z^0 decays (1992-8977)
    Amsterdam : Elsevier
    Physics Letters B 294 (1992), S. 466-478 
    Details
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(92)91549-O
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Measurement of the average lifetime of b hadrons (1993-4325)
    Amsterdam : Elsevier
    Physics Letters B 317 (1993), S. 474-484 
    Details
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(93)91027-K
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  • 3
    Online Resource
    Online Resource
    Umami : Taste for Health (2024)
    Cham : Springer International Publishing
    Details
    Subject(s): Food Microbiology. ; Food science. ; Food Sensory evaluation. ; Nutrition   . ; Food Analysis. ; Chemistry. ; Food Microbiology. ; Food Science. ; Sensory Evaluation. ; Nutrition. ; Food Chemistry.
    In: Springer Nature eBook
    Description / Table of Contents: This Open Access book covers the concept of umami, the unique taste imparted by the amino acid glutamate, was first described in 1908 by Dr. Kikunae Ikeda of Tokyo University. Over the past century, hundreds of studies have explored the mechanistic underpinnings of the taste, leading to the characterization of the umami taste receptor in 2002. How this fifth basic taste figures into nutrition and health, however, remains underexplored. Umami: Taste for Health provides an overview of the relationship between umami and human health. Authors explain how glutamate not only produces a characteristic oral sensation in the mouth but also functions as a signaling molecule to induce physiological responses. With the support of recent studies, the book demonstrates how the taste properties of umami make glutamate a promising substance to lower salt intake, promote satiation and support healthier aging. The text also covers practical culinary applications to increase umami flavor and practical usage of umami for promoting healthy eating. Provides an overview of the relationship between umami and human health; Explores the potential of glutamate to lower salt intake, promote satiation and support healthier aging; Covers practical culinary applications of umami flavor and practical usage of umami for promoting healthy eating.
    Type of Medium: Online Resource
    Pages: XIII, 198 p. 33 illus. , online resource.
    Edition: 1st ed. 2024.
    ISBN: 9783031326929
    Series Statement: Food and Health,
    URL: https://doi.org/10.1007/978-3-031-32692-9
    DOI: 10.1007/978-3-031-32692-9
    Language: English
    Note: 1. Umami and MSG -- 2. Sensory Physiology of Umami -- 3. Umami and Salty: A Cooperative Pair -- 4. Protein, Umami and Satiety -- 5. Development and Umami -- 6. Umami and Healthy Aging -- 7. Umami As A Component of Healthy Diets -- 8. Practicalities from Culinology.
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  • 4
    Online Resource
    Online Resource
    Zebrafish : Methods and Protocols (2024)
    New York, NY : Springer US
    Details
    Subject(s): Biological models. ; Biology Technique. ; Biological Models. ; Biological Techniques.
    In: Springer Nature eBook
    Description / Table of Contents: This fully updated edition introduces new tools, models, and analytic insights that position the zebrafish even more strongly as an engine of discovery for developmental and disease biology. Beginning with a section exploring detailed methods for use of zebrafish to model a variety of human diseases, the book continues by illuminating the key ongoing role of the fish model in studies of the vertebrate nervous system, tools and approaches using zebrafish to study stem cell and regenerative biology, as well as techniques in genetics and genomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Zebrafish: Methods and Protocols, Third Edition serves as an invaluable guide to propel advances in developmental biology, disease modeling, and regeneration research using zebrafish and medaka as model systems.
    Type of Medium: Online Resource
    Pages: XIV, 360 p. 94 illus., 85 illus. in color. , online resource.
    Edition: 3rd ed. 2024.
    ISBN: 9781071634011
    Series Statement: Methods in Molecular Biology, 2707
    URL: https://doi.org/10.1007/978-1-0716-3401-1
    DOI: 10.1007/978-1-0716-3401-1
    Language: English
    Note: Delivering Traumatic Brain Injury to Larval Zebrafish -- Functional Genomics of Novel Rhabdomyosarcoma Fusion-Oncogenes Using Zebrafish -- Methods to Study Liver Disease Using Zebrafish Larvae -- Developmental Toxicity Assessment Using Zebrafish-Based High Throughput Screening -- Cancer Modeling by Transgene Electroporation in Adult Zebrafish (TEAZ) -- Lineage Tracing of Bone Cells in the Regenerating Fin and during Repair of Bone Lesions -- Primary Culture of Neuronal Populations for Various Downstream Applications -- Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish -- Brain Imaging and Registration in Larval Zebrafish -- Simultaneous Behavioral and Neuronal Imaging by Tracking Microscopy -- Genetic Identification of Neural Circuits Essential for Active Avoidance Fear Conditioning in Adult Zebrafish -- Quantitative Live Imaging of Zebrafish Scale Regeneration: From Adult Fish to Signaling Patterns and Tissue Flows -- Generation of Conditional Knockout Zebrafish Using an Invertible Gene-Trap Cassette -- Spinal Cord Injury and Assays for Regeneration -- Selective Cell Ablation Using an Improved Prodrug-Converting Nitroreductase -- Section Immunostaining for Protein Expression and Cell Proliferation Studies of Regenerating Fins -- In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein -- Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones -- Mutation Knock-In Methods Using Single-Stranded DNA and Gene Editing Tools in Zebrafish -- Generation of Transgenic Fish Harboring CRISPR/Cas9-Mediated Somatic Mutations via a tRNA-Based Multiplex sgRNA Expression -- Scalable CRISPR Screens in Zebrafish Using MIC-Drop -- The Goldfish Genome and Its Utility for Understanding Gene Regulation and Vertebrate Body Morphology.
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  • 5
    Online Resource
    Online Resource
    Computational Drug Discovery and Design (2024)
    New York, NY : Springer US
    Details
    Subject(s): Pharmacology. ; Chemistry Data processing. ; Bioinformatics. ; Pharmacology. ; Computational Chemistry. ; Bioinformatics.
    In: Springer Nature eBook
    Description / Table of Contents: This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Drug Discovery and Design, Second Edition aims to effectively utilize computational methodologies in discovery and design of novel drugs.
    Type of Medium: Online Resource
    Pages: XI, 356 p. 1 illus. , online resource.
    Edition: 2nd ed. 2024.
    ISBN: 9781071634417
    Series Statement: Methods in Molecular Biology, 2714
    URL: https://doi.org/10.1007/978-1-0716-3441-7
    DOI: 10.1007/978-1-0716-3441-7
    Language: English
    Note: Computer-Aided Drug Discovery and Design – Recent Advances and Future Prospects -- Virtual Screening Process - A Guide in Modern Drug Designing -- Molecular dynamics as a tool for virtual ligand screening -- Antiviral Drug Target Identification and Ligand Discovery -- GRAMM webserver for protein docking -- Protein–ligand blind docking using CB-Dock2 -- Applications of Molecular Dynamics Simulations in Drug Discovery -- Molecular dynamics simulation-based prediction of glycosaminoglycan interactions with drug molecules -- Mining chemogenomic spaces for prediction of drug-target interactions -- Expanding the landscape of amyloid sequences with CARs-DB: a database of polar amyloidogenic peptides from disordered proteins -- Accelerating molecular dynamics simulations for drug discovery -- Exploring the Role of Chemoinformatics in Accelerating Drug Discovery: A Computational Approach. -Recent Deep-Learning Applications to Structure-Based Drug Design -- Techniques for Developing Reliable Machine Learning Classifiers Applied to Understanding and Predicting Protein:Protein Interaction Hot Spots -- AI driven enhancements in drug screening and optimisation -- Applications of big data and AI-driven technologies in CADD (computer-aided drug design) -- Artificial Intelligence in ADME Property Prediction -- Accelerating the discovery and design of antimicrobial peptides with artificial intelligence.
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  • 6
    Online Resource
    Online Resource
    High Performance Computing for Drug Discovery and Biomedicine (2024)
    New York, NY : Springer US
    Details
    Subject(s): Bioinformatics. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Computational and Systems Biology. ; Pharmacology. ; Biomedical Research.
    In: Springer Nature eBook
    Description / Table of Contents: This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
    Type of Medium: Online Resource
    Pages: XIII, 429 p. , online resource.
    Edition: 1st ed. 2024.
    ISBN: 9781071634493
    Series Statement: Methods in Molecular Biology, 2716
    URL: https://doi.org/10.1007/978-1-0716-3449-3
    DOI: 10.1007/978-1-0716-3449-3
    Language: English
    Note: Introduction to Computational Biomedicine -- Introduction to High Performance Computing -- Computational Biomedicine (CompBioMed) Centre of Excellence: Selected Key Achievements -- In Silico Clinical Trials: Is It Possible? -- Bayesian Optimization in Drug Discovery -- Automated Virtual Screening -- The Future of Drug Development with Quantum Computing -- Edge, Fog, and Cloud Against Disease: The Potential of High-Performance Cloud Computing for Pharma Drug Discovery -- Knowledge Graphs and Their Applications in Drug Discovery -- Natural Language Processing for Drug Discovery Knowledge Graphs: Promises and Pitfalls -- Alchemical Free Energy Workflows for the Computation of Protein-Ligand Binding Affinities -- Molecular Dynamics and Other HPC Simulations for Drug Discovery -- High Throughput Structure-Based Drug Design (HT-SBDD) Using Drug Docking, Fragment Molecular Orbital Calculations, and Molecular Dynamic Techniques -- HPC Framework for Performing In Silico Trials Using a 3D Virtual Human Cardiac Population as Means to Assess Drug-Induced Arrhythmic Risk -- Effect of Muscle Forces on Femur during Level Walking Using a Virtual Population of Older Women -- Cellular Blood Flow Modeling with HemoCell -- A Blood Flow Modeling Framework for Stroke Treatments -- Efficient and Reliable Data Management for Biomedical Applications -- Accelerating COVID-19 Drug Discovery with High-Performance Computing -- Teaching Medical Students to Use Supercomputers: A Personal Reflection.
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  • 7
    Online Resource
    Online Resource
    Vagus Nerve Stimulation (2024)
    New York, NY : Springer US
    Details
    Subject(s): Neurosciences. ; Neuroscience.
    In: Springer Nature eBook
    Description / Table of Contents: This volume covers the latest research and development in the areas of Vagus Nerve Stimulation (VNS) as it relates to bioelectronic medicine from neonate to adult. The chapters in this book cover topics such as invasive and non-invasive VNS including methodological considerations (study design, stimulation parameters, and use of heart rate variability metrics); mechanisms of action (automatic regulation and immune plasticity); and disorders where VNS approaches may be therapeutic (migraine and cluster headaches, mood disorders, trauma-related disorders, and language learning). In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and thorough, Vagus Nerve Stimulation is a valuable resource for both novice and expert preclinical and clinical scientists, clinicians, physicians, and scholars who are interested in learning more about this exciting and developing field.
    Type of Medium: Online Resource
    Pages: XXII, 206 p. 26 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2024.
    ISBN: 9781071634653
    Series Statement: Neuromethods, 205
    URL: https://doi.org/10.1007/978-1-0716-3465-3
    DOI: 10.1007/978-1-0716-3465-3
    Language: English
    Note: Vagus Nerve Stimulation in Peripheral Targets -- Vagal Nerve Stimulation Through the Lens of the Polyvagal Theory: Recruiting Neurophysiological Mechanisms to Dampen Threat Reactions and Promote Homeostatic Functions -- Heart Rate Variability as a Biomarker for Electrical Vagus Nerve Stimulation -- Vagus Nerve Manipulation and Microglial Plasticity in the Prenatal Brain -- Neonatal Sepsis is Diminished by Cervical Vagus Nerve Stimulation and Tracked Non-Invasively by ECG: A Pilot Report and Dataset in the Piglet Model -- Cognitive Enhancement through Vagus Nerve Stimulation: Methodological Considerations for Behavioral Studies in Rats -- Better Mood through Vagus Nerve Stimulation -- Transcutaneous Vagal Nerve Stimulation in Trauma Spectrum Psychiatric Disorders -- Vagus Nerve Stimulation for Migraine and Cluster Headaches -- Vagus Nerve Stimulation and Language Learning. .
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  • 8
    Online Resource
    Online Resource
    Food Allergens : Methods and Protocols (2024)
    New York, NY : Springer US
    Details
    Subject(s): Immunology. ; Allergy. ; Food science. ; Immunology. ; Allergology. ; Food Science.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume provides a comprehensive collection of methods and protocols in food allergy and food allergens studies. The selected protocols explore the study of food allergens, from recombinant production, purification procedures, IgE and T cell epitopes characterization, to allergen structure description, cellular responses, and tolerance induction, through a variety of techniques and animal models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Food Allergens: Methods and Protocols serves as an ideal reference for scientists at all stages involved in the study of food allergy and allergenic components.
    Type of Medium: Online Resource
    Pages: XII, 377 p. 73 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2024.
    ISBN: 9781071634530
    Series Statement: Methods in Molecular Biology, 2717
    URL: https://doi.org/10.1007/978-1-0716-3453-0
    DOI: 10.1007/978-1-0716-3453-0
    Language: English
    Note: Food Allergens of Plant and Animal Origin: Classification, Characteristics, and Properties -- Purification of Food Allergens from Their Natural Sources: Chromatographic Methods -- Recombinant Production of Food Allergens in Yeast Pichia pastoris -- Yeast Surface Display Methodology for the Characterization of Food Allergens In Situ -- Characterization of Linear IgE-Binding Epitopes in Food Allergens -- Characterization of T-Cell Epitopes in Food Allergens by Bioinformatic Tools -- Phage Immunoprecipitation Sequencing (PhIP-Seq) for Analyzing Antibody Epitope Repertoires against Food Antigens -- 1D-, 2D-Gel Electrophoresis, Immunoblotting, and Enzyme-Linked Immunosorbent Assay (ELISA) for the Study of Food Allergens -- Preparation of Blinded Food Matrixes for Clinical Oral Challenges -- Structural Characterization of Food Allergens by Nuclear Magnetic Resonance Spectroscopy -- Co-Culture of Human Dendritic and T Cells for the Study of Specific T Cell-Mediated Responses against Food Allergens -- Evaluation of the Suppressive Capacity of Regulatory T Cells in Food Allergy Research -- Mass Cytometry in Food Allergy Research -- Indirect Basophil Activation Test for Peanut Allergy Diagnosis Using Human Donor Basophils -- Standardization of Food Allergen Measurements Using Multiplex Array Technology -- Biosensors for the Detection of Food Allergens -- Standardization of a Mass Spectrometry-Based Workflow for Food Allergen Quantification -- Identifying Similar Allergens and Potentially Cross-Reacting Areas Using Structural Database of Allergenic Proteins (SDAP) Tools and D-Graph -- Validation Procedures for Quantification of Food Allergens by Enzyme-Linked Immunosorbent Assay (ELISA) -- Detection of Bet v 1 Homologous Proteins and Plant Profilins by Indirect ELISA -- A Mouse Model of Shrimp Allergy with Cross-Reactivity to Crab and Lobster -- Animal Models in the Study of Food Allergens: Long-Term Maintenance of Allergic Reactivity in Mouse Models of Food Allergy -- Study of MicroRNAs Expression in Food Allergy -- De Novo Transcriptomic Analyses to Identify and Compare Allergens in Foods -- Chromatin Immunoprecipitation Sequencing (ChIP-Seq) Assay in Food Allergy Research.
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  • 9
    Book
    Book
    Basic immunology : functions and disorders of the immune system (2024)
    Philadelphia, PA : Elsevier
    Details
    Subject(s): Immunity. ; Hypersensitivity ; Immune System physiology ; Immunologic Deficiency Syndromes.
    Type of Medium: Book
    Pages: v, 345 pages : , illustrations (chiefly color) ; , 24 cm
    Edition: 7th edition.
    ISBN: 9780443105197
    Language: English
    Location/Call number: Library / QR181:099(7)
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  • 10
    Online Resource
    Online Resource
    Tissue-Resident Macrophages : Methods and Protocols (2024)
    New York, NY : Springer US
    Details
    Subject(s): Cytology. ; Immunology. ; Bacteria. ; Cell Biology. ; Immunology. ; Bacteria.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.
    Type of Medium: Online Resource
    Pages: XVI, 576 p. 128 illus., 120 illus. in color. , online resource.
    Edition: 1st ed. 2024.
    ISBN: 9781071634370
    Series Statement: Methods in Molecular Biology, 2713
    URL: https://doi.org/10.1007/978-1-0716-3437-0
    DOI: 10.1007/978-1-0716-3437-0
    Language: English
    Note: Macrophage Development and Function -- Fate Mapping Macrophages: From Ontogeny to Functions -- Studying Autophagy in Microglia: Overcoming the Obstacles -- Hemocyte Nuclei Isolation from Adult Drosophila melanogaster for snRNA-Seq -- Isolation of Tissue Macrophages in Adult Zebrafish -- Genetic and Immunohistochemistry Tools to Visualize Rat Macrophages In Situ -- Phenotyping of Macrophages in Human Immune System Mice -- Fate-Mapping of Yolk Sac-Derived Macrophages -- Fate-Mapping of Hematopoietic Stem Cell-Derived Macrophages -- Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue -- Isolation and Flow Cytometry Analysis of Macrophages from the Dermis -- Isolation and Flow Cytometry Analysis of Macrophages from the Kidney -- Isolation and Flow Cytometry Analysis of Intestinal Macrophages -- Isolation and Characterization of Testis Macrophages Using Flow Cytometry -- Studying Macrophages in the Murine Fatty Liver Using Flow Cytometry and Confocal Microscopy -- Isolation, Ex Vivo Expansion, and Lentiviral Transduction of Alveolar Macrophages -- Translatome Profiling of Tissue-Resident Macrophages Using the RiboTag Approach -- Spectral Flow Cytometry Analysis of Resident Tissue Macrophages -- Unveiling Macrophage Heterogeneity and Their Spatial Distribution Using Multiplexed Tissue Imaging -- 3D Imaging of Macrophages in Complete Organs -- Whole-Mount Imaging of Adipose Tissue Macrophages -- Functional In Vivo Imaging of Macrophages -- Elucidating Immune Monitoring of Tissue-Resident Macrophages by Intravital Microscopy -- Combined Host-Pathogen Fate Mapping to Investigate Lung Macrophages in Viral Infection -- Measuring the Metabolic State of Tissue-Resident Macrophages via SCENITH -- Analyzing Fcg-Receptor Interactions on Monocytes with the Proximity Ligation Assay (PLA) -- Studying Efferocytosis Dynamics in Tissue-Resident Macrophages Ex Vivo -- Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation -- Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation -- Detection of G-Quadruplex DNA Structures in Macrophages -- Adaptation of Human iPSC-Derived Macrophages Towards an Alveolar Macrophage-Like Phenotype Post Intra-Pulmonary Transfer into Murine Models -- Tackling Tissue Macrophage Heterogeneity by SplitCre Transgenesis -- Automated Cell Counting of Macrophages In Situ -- Morphometric Analyses of Macrophages -- Combined Analysis of mRNA Expression and Open Chromatin in Microglia.
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  • 11
    Unknown
    Unknown
    Fields Virology.; Vol 4,: Fundamentals / (2024)
    Philadelphia : Wolters Kluwer
    Details
    Type of Medium: Unknown
    Pages: vii, 668 p. : , ill.
    Edition: 7th ed.
    ISBN: 9781975112516
    Language: English
    Note: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Location/Call number: Library / QR360:271(7)/4
    Location/Call number: F035 / F035:014
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  • 12
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    S2k guideline for diving accidents (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS German Medical Science; VOL: 21; DOC01 /20230303/
    Details
    Publication Date: 2023-03-27
    Description: For the purposes of this guideline, a diving accident is defined as an event that is either potentially life-threatening or hazardous to health as a result of a reduction in ambient pressure while diving or in other hyperbaric atmospheres with and without diving equipment. This national consensus-based guideline (development grade S2k) presents the current state of knowledge and recommendations on the diagnosis and treatment of diving accident victims. The treatment of a breath-hold diver as well as children and adolescents does not differ in principle.In this regard only unusual tiredness and itching without visible skin changes are mild symptoms.The key action statements: on-site 100% oxygen first aid treatment, immobilization/no unnecessary movement, fluid administration and telephone consultation with a diving medicine specialist are recommended.Hyperbaric oxygen therapy (HBOT) remains unchanged as the established treatment in severe cases, as there are no therapeutic alternatives. The basic treatment scheme recommended for diving accidents is hyperbaric oxygenation at 280 kPa.
    Description: Ein Tauchunfall im Sinne dieser Leitlinie ist ein potenziell lebensbedrohliches oder gesundheitsschädigendes Ereignis, hervorgerufen durch Abfall des Umgebungsdruckes beim Tauchen oder aus sonstiger hyperbarer Atmosphäre mit und ohne Tauchgerät. Diese nationale S2k-Leitlinie legt den aktuellen Stand der Erkenntnisse und der konsentierten Empfehlungen in der Diagnostik und Behandlung von Patienten nach Tauchunfällen dar. Die Behandlung von Apnoetauchern sowie Kindern und Jugendlichen unterscheidet sich prinzipiell nicht.Milde Symptome sind nur die auffällige Müdigkeit und ein Hautjucken ohne sichtbare Hautveränderungen.Wesentliche Bedeutung bei der Versorgung von Tauchunfällen hat die frühzeitige Atmung von 100%igem Sauerstoff. Weiterhin werden die Ruhiglagerung/keine unnötige Bewegung, eine moderate Flüssigkeitsgabe und eine Taucherärztliche Telefonberatung empfohlen.Die hyperbare Sauerstofftherapie (HBOT) ist bei schweren Dekompressionsunfällen unverändert ohne therapeutische Alternative. Als Behandlungsschema wird grundsätzlich eine HBOT bei 280 kPa empfohlen.
    Subject(s): diving accident ; decompression sickness ; decompression illness ; arterial gas embolism ; oxygen ; hyperbaric oxygen therapy ; Tauchunfall ; Dekompressionserkrankung ; arterielle Gasembolie ; Sauerstoff ; hyperbare Sauerstofftherapie ; ddc: 610
    Language: English
    Type: article
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    GERMAN MEDICAL SCIENCE
  • 13
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    Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC07 /20230327/
    Details
    Publication Date: 2023-03-27
    Description: The objective is to provide a comprehensive overview of the rapidly developing field of the current state of research on in vivo use of hypochlorous acid (HOCl) to aid infection prevention and control, including naso-pharyngeal, alveolar, topical, and systemic HOCl applications. Also, examples are provided of dedicated applications in COVID-19. A brief background of HOCl's biological and chemical specifics and its physiological role in the innate immune system is provided to understand the effect of in vivo applications in the context of the body's own physiological defense mechanisms.
    Description: Es wird ein umfassender Überblick über den aktuellen Stand der Forschung zum In-vivo-Einsatz von hypochloriger Säure (HOCl) zur Infektionsprävention und -bekämpfung gegeben. Der Schwerpunkt liegt auf nasalen, alveolären und topischen Anwendungen. Außerdem werden Beispiele für spezielle Anwendungen bei COVID-19 vorgestellt. Um die Wirkung von HOCl im Zusammenwirken mit körpereigenen physiologischen Abwehrmechanismen zu verstehen, werden die biologischen und chemischen Besonderheiten von HOCl und seiner physiologischen Rolle im humanen Immunsystem erläutert
    Subject(s): hypochlorous acid ; in vivo application ; HOCl chemistry ; innate immune response ; tissue compatibility ; infection control ; inhalation ; wound care ; disinfection ; Hypochlorige Säure ; In-vivo-Anwendung ; HOCl-Chemie ; physiologische Immunantwort ; Gewebeverträglichkei ; Infektionsprävention ; Inhalation ; Wundpflege ; Desinfektion ; ddc: 610
    Language: English
    Type: article
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    GERMAN MEDICAL SCIENCE
  • 14
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    Pseudomelanoma: occult intraocular foreign body mimicking choroidal melanoma (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC03 /20230130/
    Details
    Publication Date: 2023-02-04
    Description: Purpose: To report an occult intraocular foreign body mimicking choroidal melanoma. Methods: Medical records and imagings of the patient were retrospectively reviewed.Case description: A 76-year-old male was referred to our ocular oncology clinic with a suspicious hyperpigmented retinal lesion in the left eye. Biomicroscopy showed aphakia and peripheral iridectomy in the left eye. Fundoscopy revealed a pigmented, slightly elevated lesion on the macula of the left eye surrounded by diffuse atrophy. B-scan ultrasonography showed a preretinal hyperechoic lesion with posterior shadowing. There was no choroidal mass in B-scan or optical coherence tomography (OCT) imaging. On further questioning, it was disclosed that the patient had been hit by an iron fragment in the left eye forty years ago.Conclusion: Choroidal melanoma is a vision- and life-threatening intraocular malignant tumour. Various neoplastic, degenerative, and inflammatory conditions can simulate choroidal melanoma. A previous history of penetrating ocular trauma should lead the surgeon to re-evaluate a diagnosis of melanoma.
    Subject(s): choroid hemorrhage ; choroid neoplasms ; choroidal neovascularization ; foreign bodies ; eye injuries ; Aderhautblutung ; Aderhautneoplasmen ; choroidale Neovaskularisation ; Fremdkörper ; Augenverletzungen ; ddc: 610
    Language: English
    Type: article
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    GERMAN MEDICAL SCIENCE
  • 15
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    Covid-19 vaccination acceptance and hesitancy among the Turkish adult population (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC01 /20230117/
    Details
    Publication Date: 2023-01-18
    Description: Objective: The aim of this study was to determine the acceptance of Covid-19 vaccine among the Turkish adult population. Methods: A total of 2023 persons participated in this cross-sectional study between October 2020 and January 2021. The questionnaire, which was delivered via social media, was filled out by the participants over "Google Forms".Results: Questionnaire results showed that 68.7% of the participants might agree to vaccinated against COVID-19. According to univariate analysis, the age group of 50-59, urban residents, healthcare workers, non-smokers, and those with chronic diseases, those who were vaccinated against influenza, pneumonia, and tetanus were all willing to be vaccinated against COVID-19.Conclusions: It is very important to determine a community's willingness to be vaccinated against COVID-19 so that interventions can be made to solve related problems. Risk of exposure and importance of Prevention play a critical role in vaccination acceptance.
    Description: Zielsetzung: Ziel der Studie war es, die Akzeptanz der Covid-19 Impfung in der türkischen Erwachsenenbevölkerung zu ermitteln.Methode: An der Querschnittsstudie nahmen zwischen Oktober 2020 und Januar 2021 2023 Personen teil. Der Fragebogen, der über soziale Medien übermittelt wurde, wurde von den Teilnehmern über "Google Forms" ausgefüllt.Ergebnisse: 68,7% der Teilnehmer stimmen der Impfung gegen COVID-19 zu. Die univariate Analyse ergab, dass die Altersgruppe der 50- bis 59-Jährigen, Stadtbewohner, Beschäftigte im Gesundheitswesen, Nichtraucher und chronisch Kranke sowie diejenigen, die gegen Influenza, Lungenentzündung und Tetanus geimpft waren, alle bereit waren, sich gegen COVID-19 impfen zu lassen.Schlussfolgerung: Es ist wichtig, die Bereitschaft einer Gemeinschaft zu ermitteln, sich gegen COVID-19 impfen zu lassen, damit Maßnahmen zur Lösung der damit verbundenen Probleme ergriffen werden können. Das Expositionsrisiko und die Erkennung von Gefahren spielen eine entscheidende Rolle für die Akzeptanz der Impfung.
    Subject(s): Covid-19 ; vaccine ; risk ; protectionimmunization ; Covid-19 ; Impfstoff ; Risiko ; Schutz ; Impfung ; ddc: 610
    Language: English
    Type: article
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  • 16
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    Besseres Hören mit neuen Verfahren - ein Rück- und Ausblick (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC02 /20230120/
    Details
    Publication Date: 2023-01-21
    Subject(s): ddc: 610
    Language: German
    Type: article
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  • 17
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    Mit Lichtstrahlen das Gehör wiederherstellen (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC01 /20230120/
    Details
    Publication Date: 2023-01-21
    Description: When hearing fails, cochlear implants (CIs) provide most CI users with open speech understanding in quiet environments. CIs bypass the defective sensory organ and electrically stimulate the auditory nerve. The bottleneck of hearing rehabilitation with currently available CIs is their limitation in encoding spectral information resulting from the broad current spread from each electrode contact. Because light can be confined in space more conveniently, optogenetic stimulation of the auditory nerve represents a promising alternative. The development of optogenetic stimulation for future optical CIs requires efforts to design and characterize appropriate optogenetic actuators, viral gene transfer to neurons, and development of multichannel optical CIs. This review article reports the current status of optogenetic stimulation of the auditory pathway and recent breakthroughs in achieving high temporal precision and frequency resolution and in establishing multichannel optical CIs.
    Description: Wenn das Hören versagt, bieten Cochlea-Implantate (CIs) den meisten der CI-Träger ein offenes Sprachverstehen in ruhiger Umgebung. CIs umgehen das defekte Sinnesorgan und stimulieren den Hörnerv elektrisch. Der Flaschenhals der Hörrehabilitation mit aktuell verfügbaren CIs ist deren Limitierung bei der Kodierung spektraler Information, die sich aus der breiten Stromausbreitung von jedem Elektrodenkontakt ergibt. Weil Licht räumlich besser begrenzt werden kann, stellt die optische Stimulation des Hörnervs eine vielversprechende Perspektive für einen grundlegenden Fortschritt der CIs dar. Die Entwicklung der optogenetischen Stimulation für zukünftige optische CIs erfordert Anstrengungen zum Design und zur Charakterisierung geeigneter optogenetischer Aktuatoren, zum viralen Gentransfer auf die Neuronen sowie zur Entwicklung mehrkanaliger optischer CIs. Dieser Übersichtsartikel berichtet über den aktuellen Stand der optogenetischen Stimulation der Hörbahn und über die jüngsten Durchbrüche bei der Erzielung hoher zeitlicher Präzision und Frequenzauflösung sowie bei der Etablierung optischer Mehrkanal-CIs.
    Subject(s): ddc: 610
    Language: German
    Type: article
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  • 18
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    Ethanol is indispensable for virucidal hand antisepsis and without toxic risks in daily use (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC02 /20230123/
    Details
    Publication Date: 2023-01-24
    Description: The approval of ethanol by the Biocidal Products Regulation has been under evaluation since 2007 due to controversial opinions on the risk assessment. Because of this critical situation, 2022 a memorandum was published to verify whether the use of ethanol for hand antisepsis poses any hazard. On the basis of the memorandum a toxicological evaluation of ethanol-based hand rubs is given.
    Description: Die Bewertung von Ethanol als Biozid gemäß der Biozid-Verordnung wird seit 2007 aufgrund kontroverser Meinungen zur Risikobewertung geprüft. Wegen dieser kritischen Situation wurde 2022 ein Memorandum veröffentlicht, um zu überprüfen, ob die Verwendung von Ethanol zur Händedesinfektion eine Gefahr darstellt. Auf der Grundlage des Memorandums wird eine zusammenfassende toxikologische Bewertung Ethanol basierten Händedesinfektionsmittel gegeben.
    Subject(s): biocidal product regulation ; 1-propanol ; 2-propanol ; ethanol ; ethanol based hand rubs ; benefit-risk-assessment ; virucidal efficacy ; dermal absorption ; worker safety ; patient safety ; Biozid-Verordnung ; 1-Propanol ; 2-Propanol ; Ethanol ; Ethanol basierte Händedesinfektionsmittel ; Nutzen-Risiko-Bewertung ; Viruzidie ; dermale Resorption ; Mitarbeitersicherheit ; Patientensicherheit ; ddc: 610
    Language: English
    Type: article
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  • 19
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    Online-Kunsttherapie in Zeiten von Corona? Eine Darstellung digitaler Kunsttherapie am Beispiel Spanien (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Journal of Arts Therapies; VOL: 5; DOC01 /20230125/
    Details
    Publication Date: 2023-01-26
    Description: Due to the challenges posed by the COVID-19 pandemic, it has become essential to explore new and innovative ways to conduct art therapy interventions. Digital art therapy is a new way of therapy for both, art therapists and clients. In Spain, concepts for digital art therapy have already been developed and implemented not only by art therapists, but also by organisations and universities. These concepts are aimed at art therapists as part of clinical supervision, as well as at clients receiving art therapy. This paper looks at the rapidly growing area of digitally conducted art therapies and the requirements in relation to infrastructure and security, as well as the challenges and opportunities of this new way of working.
    Description: Sowohl für Kunsttherapeut:innen als auch für die Teilnehmenden ist die digitale Kunsttherapie ein noch ungewohntes Terrain. Aufgrund der COVID-19 Pandemie war es jedoch notwendig, neue und innovative Ansätze zur Durchführung von Kunsttherapie zu erarbeiten. In Spanien werden nicht nur von Kunsttherapeut:innen, sondern auch von Organisationen und Hochschulen Konzepte für die digitale Kunsttherapie durchgeführt. Diese richten sich sowohl an Kunsttherapeut:innen in Form von Supervision und Weiterbildung, als auch an Klient:innen in Form einer Therapiemaßnahme. Die vorliegende Arbeit befasst sich mit diesem rasant wachsenden Arbeitsfeld im Bereich Künstlerischer Therapien und stellt mögliche Setting- und Rahmenbedingungen, Herausforderungen sowie Möglichkeiten für die digitale Kunsttherapie zusammenfassend dar.
    Subject(s): art therapies ; digital space ; online art therapy ; Spain ; COVID-19 ; Künstlerische Therapien ; digitaler Raum ; Online-Kunsttherapie ; Spanien ; COVID-19 ; ddc: 610
    Language: German
    Type: article
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  • 20
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    Compliance assessment regarding the PVC management on normal wards of a university hospital (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC04 /20230127/
    Details
    Publication Date: 2023-01-28
    Description: Objective: The risk of peripheral venous catheter (PVC) infections in inpatients is often underestimated, even if it is lower than that for central venous catheters. Guidelines for the prevention of PVC-associated infections describe the evidence-based management of PVCs. The aims of this study were the development of standardized methods for compliance assessment regarding PVC management and the evaluation of self-reported knowledge and implementations among healthcare providers regarding PVC care.Method: We developed a checklist based on the recommendation of the Commission of Hospital Hygiene and Infection Prevention at the Robert Koch Institute (KRINKO) Berlin for the standardized evaluation of PVC management. The following parameters were collected and evaluated: condition of the puncture site, condition of the bandage, presence of an extension set, presence of a plug, and documentation. The checklist was applied in 14 normal wards in 2019. After feedback of the ward staff on the results, it was applied again in 2020 in the same wards. For retrospective data analysis, we used a newly developed PVC-quality index. After the second evaluation in 2020, we carried out an anonymous survey among the healthcare providers.Results: The evaluation of 627 indwelling PVCs showed a significant increase in compliance related to the presence of an extension set (p=0.049) and documentation (p〈0.001) in the 2nd year. The quality index increased in 12 out of 14 wards. The participants of the survey were aware of the in-house standard "Prevention of vascular catheter-associated infections", with a mean score of 4.98 on a Likert scale (1=not aware, 7=completely aware). The main barrier to implementation of the preventive measures was the time factor. Survey participants were more aware of PVC placement than PVC care.Conclusion: The PVC quality index is a valuable tool for the assessment of compliance regarding PVC management in daily practice. Feedback from the ward staff on the results of compliance assessment improves PVC management, but the outcome is very heterogeneous.
    Description: Zielsetzung: Das Infektionsrisiko von peripheren Venenkathetern (PVK) bei stationären Patienten wird, auch wenn es niedriger ist als das von zentralen Venenkathetern, häufig unterschätzt. Leitlinien zur Prävention von PVK-assoziierten Infektionen beinhalten Evidenz-basierte Maßnahmen zur Anlage, Pflege und Nutzung von liegenden PVK. Ziel dieser Studie war, ein Verfahren zur standardisierten Bewertung der Compliance im Umgang mit liegenden PVK zu entwickeln und zu testen. Außerdem sollte eine Selbsteinschätzung des Personals zu Kenntnis und Umsetzung der Präventionsmaßnahmen erhoben werden.Methode: Basierend auf den KRINKO-Empfehlungen wurde eine Checkliste zur standardisierten Bewertung der Umsetzung von Präventionsmaßnahmen bei liegenden PVK entwickelt. Folgende Parameter wurden erhoben und bewertet: Zustand der Punktionsstelle, Zustand des Verbands, Vorhandensein eines Extensionssets, Verschluss, Nutzung und Dokumentation der Maßnahmen. Die Checkliste wurde erstmals im Jahr 2019 auf 14 Normalstationen angewendet und nach Feedback der Ergebnisse erneut im Jahr 2020 auf denselben Stationen eingesetzt. Mithilfe eines neu entwickelten PVK-Qualitätsindex erfolgte ein retrospektiver Vergleich. Nach der 2. Bewertung wurde eine anonyme Mitarbeiterbefragung mittels Fragebogen durchgeführt.Ergebnisse: Bei der Bewertung von 627 liegenden PVK zeigte sich eine signifikante Steigerung der Compliance bezogen auf das Vorhandensein eines Extensionssets (p=0,049) und die Dokumentation (p〈0,001) im 2. Jahr. Der Qualitätsindex ist auf 12 der 14 beobachteten Stationen gestiegen. Die Bekanntheit einzelner Maßnahmen des hausinternen Standards "Prävention gefäßkatheterassoziierter Infektionen" wurde mit dem Mittelwert 4,98 von 7 auf einer Likert-Skala angegeben; als einziges Hindernis in der Umsetzung konnte der Faktor Zeit identifiziert werden. Maßnahmen bei PVK-Anlage waren zu einem höheren Anteil bekannt als Maßnahmen der PVK-Pflege. Fazit: Der PVK-Qualitätsindex ist erfolgreich angewendet worden und ist geeignet, die PVK-bezogene Compliance standardisiert zu erheben. Feedback der Compliance im Umgang mit PVK hat diese verbessert, aber der Effekt ist sehr heterogen.
    Subject(s): catheter related infection ; peripheral venous catheter ; compliance assessment ; compliance self-assessment ; peripheral venous catheter quality index ; Katheter-assoziierte Infektion ; peripherer Venenkatheter ; Compliance-Bewertung ; Compliance-Selbsteinschätzung ; PVK-Qualitätsindex ; ddc: 610
    Language: English
    Type: article
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  • 21
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    Safe injection, infusion and medication-vial practices at a tertiary care centre: a quality improvement initiative (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 18; DOC03 /20230127/
    Details
    Publication Date: 2023-01-28
    Description: Introduction: There is a risk of transmission of viruses and microbial pathogens during routine health care procedures due to improper injection, infusion, and medication-vial practices. Unsafe practices lead to outbreaks of infection resulting in unacceptable and devastating events in patients. The present study was undertaken to assess the compliance of nurses with safe injection and infusion practices in our hospital and to identify staff education requirements in relation to the safe-injection and infusion practices policy.Methods: Baseline data were collected and high risk areas were identified on this basis, a quality improvement project was implemented by infection control team. FOCUS PDCA methodology was used to conduct the improvement process. The study was performed from March to September 2021. An audit checklist based on the CDC guidelines was used for monitoring compliance with safe injection and infusion practices. Results: Poor compliance with safe injection and infusion practices in few clinical areas at baseline. During the pre-intervention period, non-compliance was mainly seen with the following elements: aseptic technique (79%), rubber septum disinfected with alcohol (66%), labelling of all IV lines and medications with date and time (83%), compliance with multidose-vial policy (77%), use of multidose vials for single patient (84%), safe disposal of sharps (84%), using trays instead of clothing/pockets to carry medications (81%).There was significant improvement in compliance with the following elements of safe injection and infusion practices in the post-intervention period: aseptic technique (94%), rubber septum disinfected with alcohol (83%), compliance with multidose-vial policy (96%), use of multidose vials for single patient only (98%), safe disposal of sharps (96%).Conclusion: Adherence to safe injection and infusion practices is very important to prevent outbreaks of infection in health care settings.
    Description: Einführung: Im Fall unsachgemäßer Injektion, Infusion und fehlerhaften Umgangs mit Medikamenten besteht das Risiko der Übertragung von Viren und Mikroorganismen. Fehlerhafte Praktiken können zum Ausbruch von Infektionen mit drastischen Folgen für die Patienten führen. Die vorliegende Studie wurde durchgeführt, um die Einhaltung sicherer Injektions- und Infusionspraktiken in unserem Krankenhaus durch das Pflegepersonal zu bewerten und den Schulungsbedarf des Personals zu ermitteln.Methoden: Die Analyse der Ausgangssituation ergab eine schlechte Einhaltung sicherer Injektions- und Infusionspraktiken in einigen klinischen Bereichen. In den identifizierten Bereichen mit hohem Risiko wurde vom Infektionskontrollteam ein Qualitätsverbesserungsprojekt etabliert. Zur Durchführung wurde die FOCUS PDCA-Methode verwendet. Die Studie erstreckte sich von März bis September 2021. Zur Überwachung der Einhaltung sicherer Injektions- und Infusionspraktiken wurde eine Audit-Checkliste auf der Grundlage der CDC-Richtlinien verwendet.Ergebnisse: Während der Zeit vor der Intervention wurde die Nichteinhaltung hauptsächlich in Bezug auf folgende Elemente festgestellt: Aseptische Technik (79%), mit Alkohol desinfiziertes Gummiseptum (66%), Kennzeichnung aller Infusionsleitungen und Medikamente mit Datum und Uhrzeit (83%), Einhaltung der Richtlinie für Mehrdosisfläschchen (77%), Verwendung von Mehrdosisfläschchen für einen einzelnen Patienten (84%), sichere Entsorgung von scharfen Gegenständen (84%), Tragen von Medikamenten in Kleidung/Taschen anstatt auf dem Tablett (81%).Es gab eine signifikante Verbesserung bei der Einhaltung der folgenden Elemente sicherer Injektions- und Infusionspraktiken nach der Intervention: Aseptische Technik (94%), mit Alkohol desinfiziertes Gummiseptum (83%), Einhaltung der Richtlinie für Mehrdosis-Durchstechflaschen (96%), Verwendung von Mehrdosis-Durchstechflaschen für einen einzelnen Patienten (98%), sichere Entsorgung scharfer Gegenstände (96%).Schlussfolgerung: Die Einhaltung sicherer Injektions- und Infusionspraktiken ist unerlässlich, um Ausbrüche nosokomialer Infektionen zu verhindern.
    Subject(s): safe injection and infusion practices ; aseptic techniques ; single syringe ; single needle ; single patient ; multidose-vial policy ; labelling of IV lines ; safe disposal of sharps ; sichere Injektions- und Infusionspraktiken ; aseptische Technik ; Einzelspritze ; Einzelnadel ; Einzelpatient ; Mehrdosisfläschchen ; Kennzeichnung von Infusionsleitungen ; sichere Entsorgung scharfer Gegenstände ; ddc: 610
    Language: English
    Type: article
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  • 22
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    A rare cause of recurrent subconjunctival hemorrhage: ocular vicarious menstruation (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC05 /20230130/
    Details
    Publication Date: 2023-01-31
    Description: Purpose: Vicarious menstruation is cyclical bleeding in extra-uterine locations that occurs during menstruation or within 48 h of its onset. We aim to present a 43-year-old female with ocular vicarious menstruation, its treatment, and a review of other published cases of ocular vicarious menstruation. Case presentation: A 43-year-old Caucasian female presented with a 15-year history of recurrent monthly unilateral subconjunctival hemorrhage. The episodes were cyclical and coincided with the onset of menses, lasting for approximately 10 to 14 days. Slit-lamp examination of the right eye showed nasally located subconjunctival hemorrhage. Detailed laboratory findings, including parameters for various hematological disorders, were normal. A follow-up examination 2 weeks later showed that the subconjunctival hemorrhage in the right eye was completely resolved. The patient was prescribed the oral contraceptive levonorgestrel/ethinyl estradiol and marked improvement at the recurrences of subconjunctival hemorrhage was noted during subsequent menses.Conclusion: Ocular vicarious menstruation is among the rarest causes of recurrent subconjunctival hemorrhage. A therapeutic trial of oral contraceptive should be considered in patients that present with ocular vicarious menstruation.
    Subject(s): recurrent subconjunctival hemorrhage ; ocular vicarious menstruation ; extrauterine bleeding ; oral contraceptive pills ; ddc: 610
    Language: English
    Type: article
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  • 23
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    Surgically induced scleral necrosis associated with concomitant tuberculosis infection: a diagnostic challenge (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC04 /20230130/
    Details
    Publication Date: 2023-01-31
    Description: Objective: Surgically induced scleral necrosis (SISN) is a potentially blinding sequela that may occur after any ocular procedure. SISN in the context of active tuberculosis is seldom seen. We report a case of a patient with asymptomatic tuberculosis who developed SISN after pterygium surgery.Methods: A 76-year-old Mexican-mestizo woman from Veracruz, Mexico, was referred to our clinic because of severe disabling pain and scleral thinning in her right eye.Results: Tubercular-related SISN was finally diagnosed and managed successfully with antitubercular therapy, topical and systemic corticosteroidsConclusion: Tuberculosis must be considered as a differential diagnosis of high-risk patients in the context of refractory SISN in endemic countries.
    Subject(s): antitubercular therapy ; infectious scleritis ; necrotizing scleritis ; ocular tuberculosis ; pterygium surgery ; scleral inflammation ; surgically induced scleral necrosis ; ddc: 610
    Language: English
    Type: article
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  • 24
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    Vorteile des direkten akustischen Streamens beim Telefonieren bimodal versorgter Hörsystemnutzer (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC03 /20230131/
    Details
    Publication Date: 2023-02-01
    Description: The present study investigated whether direct bilateral streaming on cochlea implant (CI) and hearing aid provides bimodal hearing instrument users with an advantage when making phone calls via smartphone compared with previously used methods.In two laboratory tests, 22 experienced CI listeners (mean age 50.8±18.6 years), fitted bimodally with a Cochlear N7 processor, as well as a GN ReSound hearing aid, were tested with their own previously used, mostly unilateral phone use (reference condition) and with MFi technology (test condition). In the test condition, signals were directly streamed from a smartphone to both hearing instruments. Speech intelligibility, subjectively perceived listening effort, each in interfering noise, and subjective ratings (including sound, usability via System Usability Scale, SUS) were obtained as key measures of benefit. The results showed a trend towards improved speech intelligibility, as well as a significantly lower listening effort with bilateral streaming compared to conventional telephone use in both the measurement and the questionnaire data. In terms of usability, bilateral streaming also resulted in better ratings compared to the reference.
    Description: In der vorliegenden Studie wurde untersucht, ob das direkte bilaterale Streamen in Cochlea-Implantat (CI) und Hörgerät (HG) bimodalen Hörsystemnutzern einen Vorteil beim Telefonieren mit dem Smartphone im Vergleich zu bisher genutzten Verfahren bringt. In zwei Labortests wurden 22 erfahrene CI-Träger (Durchschnittsalter 50,8±18,6 Jahre), die bimodal mit einem N7 Prozessor der Firma Cochlear sowie einem GN ReSound Hörgerät versorgt waren, mit ihrer eigenen bisher genutzten, meist unilateralen Telefonnutzung (Referenz-Kondition) sowie mit MFi-Technologie (Test-Kondition) getestet. In der Test-Kondition wurde direkt von einem Smartphone auf beide Hörsysteme gestreamt. Als wesentliche Messgrößen des Benefits wurden die Sprachverständlichkeit, die subjektiv empfundene Höranstrengung, jeweils im Störgeräusch, und subjektive Bewertungen (u.a. zu Klang, Gebrauchstauglichkeit über System Usability Scale, SUS) erfasst. Die Ergebnisse ergaben eine tendenziell verbesserte Sprachverständlichkeit, sowie eine signifikant geringere Höranstrengung bei beidseitigem Streaming im Vergleich zur herkömmlichen Telefonnutzung in sowohl den Mess-, als auch den Fragebogendaten. Im Hinblick auf Gebrauchstauglichkeit führte das beidseitige Streaming, verglichen mit der Referenz, ebenfalls zu besseren Bewertungen.
    Subject(s): cochlear implant ; MFi ; streaming ; telephoning with CI ; Cochlea-Implantat ; MFi ; Streamen ; Telefonieren mit CI ; ddc: 610
    Language: German
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  • 25
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    Staged limbal stem cell transplantation and keratoplasty surgeries as a treatment for gelatinous drop-like corneal dystrophy (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC02 /20230130/
    Details
    Publication Date: 2023-01-31
    Description: Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that has been associated with mutations in the TACSTD2 (M1S1) gene, which is normally expressed in corneal epithelial cells. GDLD is characterized by progressive deposition of amyloid in the corneal stroma with rapid recurrence in grafts after penetrating keratoplasty. We report of case of a patient with GDLD treated bilaterally with staged limbal stem cell transplantation and penetrating keratoplasty that resulted in long-term control of his disease. This case demonstrates that staged allogenic limbal stem cell transplantation, before or after penetrating keratoplasty, can be used to restore vision long-term in GDLD patients.
    Subject(s): gelatinous drop-like corneal dystrophy (GDLD) ; penetrating keratoplasty (PKP) ; allogeneic limbal stem-cell transplantation ; ddc: 610
    Language: English
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  • 26
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    Multimodal imaging in a case of bilateral astrocytic hamartoma with retinitis pigmentosa (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Ophthalmology Cases; VOL: 13; DOC01 /20230130/
    Details
    Publication Date: 2023-01-31
    Description: Astrocytic hamartoma is a benign glial tumor. It may be associated with tuberous sclerosis and can also be found incidentally on retinal examination as an isolated presentation. Here, we describe multimodal imaging characteristics of astrocytic hamartoma in a patient with retinitis pigmentosa. Spectral domain optical coherence tomography of both eyes showed moth-eaten optically empty spaces and hyperreflective dots along with foveal thinning. Multicolor image highlighted mulberry appearance of the lesion with green shift signifying elevated lesion. In infrared reflectance, lesion was hyporeflective with its margins well delineated. Green reflectance and blue reflectance highlighted calcification as multiple hyperreflective dots. Autofluorescence showed typical hyperautofluorescence.
    Subject(s): astrocytic hamartoma ; multicolor imaging ; retinitis pigmentosa ; ddc: 610
    Language: English
    Type: article
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  • 27
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    Musiktherapie - neu definiert (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Journal of Arts Therapies; VOL: 5; DOC02 /20230228/
    Details
    Publication Date: 2023-02-28
    Description: The definition of a therapeutic discipline provides an important position-fixing and offers orientation for patients, interested parties and professional actors in health care. The definition of music therapy (MT) serves both the self-portrayal of music therapists and the professional classification in the institutions of the public health care system. Thus it contributes decisively to the professional political profiling. There is currently no definition of music therapy in Germany that fits well into the German health system.In this article, different definitions are presented and critically questioned. Against the background of new developments within MT, the necessity for a new definition is shown. This is presented and explained in its conceptual components.
    Description: Die Definition einer therapeutischen Disziplin leistet eine wichtige Standortbestimmung und bietet Orientierung für Patient:innen, Interessent:innen und professionelle Akteure der Gesundheitsversorgung. Die Definition von Musiktherapie (MT) dient sowohl der Selbstdarstellung von Musiktherapeut:innen, als auch der fachlichen Einordnung in die Institutionen des öffentlichen Gesundheitswesens. Damit trägt sie entscheidend zur berufspolitischen Profilierung bei. Es gibt aktuell in Deutschland keine im deutschen Gesundheitssystem gut anschlussfähige Definition von Musiktherapie. In diesem Artikel werden verschiedene Definitionen dargestellt und kritisch hinterfragt. Vor dem Hintergrund von Neuentwicklungen innerhalb der MT wird die Notwendigkeit für eine neue Definition aufgezeigt. Diese wird vorgestellt und in ihren Begriffsbausteinen erläutert.
    Subject(s): definition ; music therapy ; intervention ; methods ; Definition ; Musiktherapie ; Intervention ; Methodik ; ddc: 610
    Language: German
    Type: article
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  • 28
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    Wissenschaft. Nah am Menschen - 68. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) e.V. (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 19; DOC13 /20230912/
    Details
    Publication Date: 2023-09-12
    Subject(s): ddc: 610
    Language: German
    Type: article
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  • 29
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    Gesundheitskioske als Technologie für bürgerzentrierte Gesundheits-IT: Werden sie genutzt und wenn nein, warum nicht? (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 19; DOC12 /20230912/
    Details
    Publication Date: 2023-09-12
    Description: Health kiosks are basically a low-threshold opportunity for communication between citizens and other actors in the healthcare system as well as for information on health-related issues. The aim of the study was to record the use of health kiosks in pharmacies by means of a quantitative long-term survey and to determine the reasons for (non-)use by means of a qualitative in-depth analysis. Overall, usage parameters were recorded over 25 months in log files of up to 145 pharmacies. In addition, 92 customers of four high-usage pharmacies were interviewed in qualitative short interviews regarding the reasons for use or non-use. The results of the long-term study showed that the health kiosks were used 1-2 times a day at best, but more likely only 1-2 times a week. The reasons for non-use were due to the interaction of different factors, including accessibility and usefulness, but also the social environment. It can be concluded that identifying the reasons for (non-)use is an important step towards allowing the potential of health kiosks to unfold if they are to be used in a targeted manner within the framework of the digitalisation strategy of the Federal Ministry of Health.
    Description: Gesundheitskioske stellen grundsätzlich eine niedrigschwellige Möglichkeit für die Kommunikation zwischen Bürgern und weiteren Akteuren im Gesundheitswesen sowie für die Information zu gesundheitsrelevanten Fragestellungen dar. Ziel der Studie war es, über eine quantitative Langzeiterhebung die Nutzung von Gesundheitskiosken in Apotheken zu erfassen und über eine qualitative Tiefenanalyse die Gründe für die (Nicht)-Nutzung zu ermitteln. Insgesamt wurden Nutzungsparameter über 25 Monate in Logdateien von bis zu 145 Apotheken festgehalten. Darüber hinaus wurden 92 Kunden von vier nutzungsstarken Apotheken in qualitativen Kurzinterviews hinsichtlich der Gründe der Nutzung bzw. Nichtnutzung befragt. Die Ergebnisse der Langzeitstudie zeigen, dass die Gesundheitskioske im besten Falle 1-2 mal pro Tag, eher aber nur 1-2 mal pro Woche genutzt wurden. Die Gründe für die Nicht-Nutzung wurden durch das Zusammenspiel unterschiedlicher Faktoren bedingt, hierzu zählten u.a. die Zugänglichkeit und die Nützlichkeit, aber auch das soziale Umfeld. Zusammenfassend lässt sich feststellen, dass die Identifizierung der Gründe für die (Nicht-)Nutzung ein wichtiger Schritt ist, damit sich das Potential von Gesundheitskiosks entfalten kann, wenn sie im Rahmen der Digitalisierungsstrategie des Bundesministeriums für Gesundheit zum gezielten Einsatz kommen sollen.
    Subject(s): self-service technology ; SST ; health kiosk ; usage ; usefulness ; Selbstbedienungstechnologien ; Gesundheitskiosk ; Nutzung ; Nutzen ; ddc: 610
    Language: German
    Type: article
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  • 30
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    Wissenschaftsausbildung im Medizinstudium: Das Oldenburger Datenanalyseprojekt als Umsetzungsbeispiel [Lessons learned] (2023)
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 19; DOC11 /20230912/
    Details
    Publication Date: 2023-09-12
    Description: Introduction: According to the Master Plan 2020, science education will play a critical role in future medical curricula. Science modules have already been implemented at many locations. Other medical faculties will follow in the next few years, as legislation is expected to make recommendations of the national competence-based learning objectives curriculum for medicine (NKLM) mandatory. This article aims to present an implementation example from epidemiology and biometry as a contribution to the didactic discussions within the data sciences in medicine. Project description: We report on our experiences with a data analysis project for second-year medical students, which has been compulsory at the Faculty of Medicine and Health Sciences since 2019. The project is intended to train the scientific skills required from the subjects of epidemiology and biometry for student research projects. Emphasis is placed on responsible data handling, transparency, and reproducibility. For example, the writing of a statistical analysis plan is required prior to data access. Improved standardization of materials, optional use of the English language, and digital support will be implemented to help manage the project when student numbers increase. Discussion: The experience from five years is very positive, although a formal evaluation of the learning success is still pending. Current challenges concern staffing, additional time and supervision requirements for those students who do statistical programming with R, and improved integration into the medical curriculum.
    Description: Einleitung: Wissenschaftsausbildung wird im Medizinstudium gemäß Masterplan 2020 künftig einen höheren Stellenwert einnehmen. An vielen Standorten sind wissenschaftliche Curricula bereits umgesetzt. Andere Fakultäten werden voraussichtlich in den nächsten Jahren nachziehen und dabei auch die Empfehlungen des Nationalen Kompetenzbasierten Lernzielkatalogs Medizin (NKLM) zu berücksichtigen haben. Ziel dieses Artikels ist die Darstellung eines Umsetzungsbeispiels aus den Fächern Epidemiologie und Biometrie als Beitrag zur fachlich-didaktischen Diskussion. Projektbeschreibung: Wir berichten von unseren Erfahrungen mit einem seit 2019 an der Fakultät für Medizin und Gesundheitswissenschaften verpflichtenden Datenanalyseprojekt für Medizinstudenten im zweiten Studienjahr. Das Projekt soll die aus den Fächern Epidemiologie und Biometrie benötigten wissenschaftlichen Kompetenzen für spätere eigene Forschungsprojekte trainieren. Dabei wird besonderer Wert auf verantwortungsvollen Umgang mit Daten, Transparenz und Reproduzierbarkeit gelegt. Beispielsweise stellt ein von den Studenten zu erstellender statistischer Analyseplan eine notwendige Voraussetzung des Datenzugangs dar. Parallel werden eine zunehmende Standardisierung der Betreuung, wahlweise Nutzung von Englisch und digitale Unterstützung umgesetzt, damit das Projekt perspektivisch auch bei ansteigenden Studentenzahlen zu bewältigen ist. Diskussion: Die Erfahrungen aus bisher 5 Jahren sind sehr positiv, wobei eine formale Evaluation des Lernerfolgs noch aussteht. Das Projekt ist sowohl für die Studenten als auch für Betreuer und Dozenten aufwändiger als derzeit abgebildet werden kann. Aktuelle Herausforderungen bestehen vor allem hinsichtlich personeller Ausstattung, zusätzlichen Zeit- und Betreuungsbedarfs derjenigen Studenten, die sich für eigene statistische Programmierung mit R entscheiden, und einer Optimierung der curricularen Einbindung.
    Subject(s): science education ; medical curriculum ; teaching goals ; epidemiology and biometry ; Wissenschaftsausbildung ; Medizinstudium ; Lernzielkatalog ; Epidemiologie und Biometrie ; ddc: 610
    Language: German
    Type: article
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  • 31
    Online Resource
    Online Resource
    Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology (2023)
    New York, NY : Springer US
    Details
    Subject(s): Bioinformatics. ; Computational and Systems Biology.
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides protocols for computational, statistical, and machine learning methods that are mainly applied to the study of metabolic engineering, synthetic biology, and disease applications. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biological complexity. The topics covered in this book are geared toward researchers with a background in engineering, computational analytical, and modeling experience and cover a broad range of topics in computational and machine learning approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology is a valuable resource for any researcher or scientist who wants to learn more about the latest computational methods and how they are applied toward the understanding and prediction of complex biology. .
    Type of Medium: Online Resource
    Pages: XII, 455 p. 160 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071626177
    Series Statement: Methods in Molecular Biology, 2553
    URL: https://doi.org/10.1007/978-1-0716-2617-7
    DOI: 10.1007/978-1-0716-2617-7
    Language: English
    Note: Challenges to Ensure a Better Translation of Metabolic Engineering for Industrial Applications -- Synthetic Biology Meets Machine Learning -- Design and Analysis of Massively Parallel Reporter Assays using FORECAST -- Modelling Protein Complexes and Molecular Assemblies using Computational Method -- From Genome Mining to Protein Engineering: A Structural Bioinformatics Route -- Creating De Novo Overlapped Genes -- Design of Gene Boolean Gates and Circuits with Convergent Promoters -- Computational Methods for the Design of Recombinase Logic Circuits with Adaptable Circuit Specifications -- Designing a Model-Driven Approach Towards Rational Experimental Design in Bioprocess Optimization -- Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology -- Genome-Scale Modeling and Systems Metabolic Engineering of Vibrio Natriegens for the Production of 1,3-Propanediol -- Application of GeneCloudOmics: Transcriptomics Data Analytics for Synthetic Biology -- Overview of Bioinformatics Software and Databases for Metabolic Engineering -- Computational Simulation of Tumor-Induced Angiogenesis -- Computational Methods and Deep Learning for Elucidating Protein Interaction Networks -- Machine Learning Methods for Survival Analysis with Clinical and Transcriptomics Data of Breast Cancer -- Machine Learning Using Neural Networks for Metabolomic Pathway Analyses -- Machine Learning and Hybrid Methods for Metabolic Pathway Modeling -- A Machine Learning Based Approach Using Multi Omics Data to Predict Metabolic Pathways.
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  • 32
    Online Resource
    Online Resource
    Phase-Separated Biomolecular Condensates : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Biochemistry. ; Bioinformatics. ; Biochemistry. ; Computational and Systems Biology.
    In: Springer Nature eBook
    Description / Table of Contents: This volume provides readers with a broad collection of theoretical, computational, and experimental methods to quantitatively study the properties of phase-separate biomolecular condensates in diverse systems. The chapters in this book cover topics such as theoretical and computational methods; methods for in vitro characterization of biomolecular condensates; and techniques that enable in-cell characterization of biomolecular condensates. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Phase-Separated Biomolecular Condensates: Methods and Protocols is a valuable resource that helps researchers learn and use established methods to study both biophysical properties and biological functions of biomolecular condensates. .
    Type of Medium: Online Resource
    Pages: XIV, 449 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071626634
    Series Statement: Methods in Molecular Biology, 2563
    URL: https://doi.org/10.1007/978-1-0716-2663-4
    DOI: 10.1007/978-1-0716-2663-4
    Language: English
    Note: Calculating Binodals and Interfacial Tension of Phase-Separated Condensates from Molecular Simulations, with Finite-Size Corrections -- Field-Theoretic Simulation Method to Study the Liquid-Liquid Phase Separation of Polymers -- Numerical Techniques for Applications of Analytical Theories to Sequence-Dependent Phase Separations of Intrinsically Disordered Proteins -- An Introduction to the Stickers-and-Spacers Framework as Applied to Biomolecular Condensates -- Multi-Scale Modeling of Protein-RNA Condensation In and Out of Equilibrium -- Fluorescence Lifetime Imaging Microscopy of Biomolecular Condensates -- Single-Molecule Fluorescence Methods to Study Protein-RNA Interactions Underlying Biomolecular Condensates -- Fluorescence Correlation Spectroscopy and Phase Separation -- Measurement of Protein and Nucleic Acid Diffusion Coefficients within Biomolecular Condensates Using In-Droplet Fluorescence Correlation Spectroscopy -- Single-Molecule Imaging of the Phase Separation-Modulated DNA Compaction to Study Transcriptional Repression -- Phase Separation-Based Biochemical Assays for Biomolecular Interactions -- Determining Thermodynamic and Material Properties of Biomolecular Condensates by Confocal Microscopy and Optical Tweezers -- A High-Throughput Method to Profile Protein Liquid-Liquid Phase Separation -- Phase Separation of Rubisco by the Folded SSUL Domains of CcmM in Beta-Carboxysome Biogenesis -- Cryo-Electron Tomography of Reconstituted Biomolecular Condensate -- Sedimentation Assays to Assess the Impact of Post-Translational Modifications on Phase Separation of RNA-Binding Proteins In Vitro and In Cells -- Synthetic Organelles for Multiple mRNA Selective Genetic Code Expansion in Eukaryotes -- Single Molecule Tracking of RNA Polymerase In and Out of Condensates in Live Bacterial Cells -- An Optogenetic Toolkit for the Control of Phase Separation in Living Cells -- Assessing the Phase Separation Propensity of Proteins in Living Cells Through Optodroplet Formation -- Mass Balance Imaging: A Phase Portrait Analysis for Characterizing Growth Kinetics of Biomolecular Condensates -- Characterizing Properties of Biomolecular Condensates Below the Diffraction Limit In Vivo.
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  • 33
    Online Resource
    Online Resource
    Protein Aggregation : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Proteins. ; Spectrum analysis. ; Proteins. ; Spectroscopy.
    In: Springer Nature eBook
    Description / Table of Contents: The volume details techniques, methods, and conceptual developments to further the study of protein aggregation with emphasis on the pleiomorphic proteins implicated in etiology of neurodegeneration. Chapters guide readers through in vitro and in vivo studies of fibrillization and liquid-liquid phase separation processes, and offer a comprehensive account of the state-of-art of structural studies of protein aggregation. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Aggregation: Methods and Protocols aims to be useful and practical guide to new researchers and experts looking to expand their knowledge.
    Type of Medium: Online Resource
    Pages: XVI, 681 p. 50 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071625972
    Series Statement: Methods in Molecular Biology, 2551
    URL: https://doi.org/10.1007/978-1-0716-2597-2
    DOI: 10.1007/978-1-0716-2597-2
    Language: English
    Note: Early aggregation of Amyloid-β (1-42) studied by Fluorescence Correlation Spectroscopy -- Preparation and investigation of crucial oligomers in the early stages of Aβ40 and Aβ42 aggregation -- Preparation and fractionation of heterogeneous Aβ42 oligomers with different aggregation properties -- An efficient method of expression and purification of amyloid beta (Aβ1-42) peptide from E.coli -- Solid-state NMR structure of amyloid-β fibrils -- Time-resolved in situ AFM measurement of growth rates of Aβ40 fibrils -- Monitoring kinetics of pH-dependent aggregation and disaggregation of the Pmel17 repeat domain -- Analysis of Tau:nucleoporin interactions by Surface Plasmon Resonance Spectroscopy -- Microfluidic chamber technology to study missorting and spreading of Tau protein in Alzheimer disease -- Using FRET-based biosensor cells to study the seeding activity of tau and α-synuclein -- Functional applications of stable tau oligomers in cell biology and electrophysiology studies -- An additive-free model for tau self-assembly -- Cross-linking mass spectrometry analysis of metastable compact structures in intrinsically disordered proteins -- A validated method to prepare stable tau oligomers -- Light microscopy and dynamic light scattering to study liquid-liquid phase separation of Tau proteins in vitro -- Study of tau liquid-liquid phase separation in vitro -- Liquid-Liquid Phase Separation to study the association of proteins in solution -- Mapping phase diagram of tau-RNA LLPS under live cell coculturing conditions -- The role of buffers in wild-type HEWL amyloid fibril formation mechanism - a methodological approach -- Reproducible formation of insulin superstructures: amyloid-like fibrils, spherulites and particulates -- CD and solid-state NMR studies of low-order oligomers of transthyretin -- Identifying biological and biophysical features of different maturation states of α-synuclein amyloid fibrils -- Preparation of α-synuclein fibril, ribbon and fibril-91 amyloid polymorphs for structural studies -- Propagation of distinct alpha-synuclein strains within human reconstructed neuronal network and associated neuronal dysfunctions -- Single-particle analysis of the interaction between molecules and protein aggregated species by Dual-Color Time-Resolved Fluorescence Spectroscopy -- FRAP & FRET investigation of α-synuclein fibrillization via liquid-liquid phase separation in vitro and in HeLa cells -- Spectrally-resolved FRET microscopy of -synuclein phase-separated liquid droplets -- Combined H-N cross polarization and carbonyl detection NMR spectroscopy allows to record high-resolution, high-sensitivity spectra of alpha-synuclein in bacterial cells -- Identification of distinct soluble states during fibril formation using multilinear analysis of NMR diffusion data -- Structural analysis of SOD1 fibrils with mass spectrometry, limited proteolysis and atomic force microscopy (AFM) -- Biophysical studies of LLPS and aggregation of TDP-43 LCD -- A spectrophotometric turbidity assay to study Liquid-Liquid Phase Separation of UBQLN2 in vitro -- An optimized SG detection method: Investigation of UBQLN2 effect on RNA-FUS interaction and SG formation -- Neuronal puncta/aggregate formation by wild-type and mutant UBQLN2 -- In vivo analysis of a biomolecular condensate in the nervous system of C. elegans -- FLIM-FRET investigation of heterogeneous huntingtin aggregation in HeLa cells -- In vitro characterization of protein:nucleic acid liquid-liquid phase separation by microscopy methods and nanoparticle tracking analysis -- Cross-seeding assay in the investigation of the amyloid core of prion fibrils -- Mapping the domain structure and aggregation propensity of proteins using a Gateway plasmid vector system.
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  • 34
    Online Resource
    Online Resource
    Introducing Computation to Neuroscience : Selected Papers of George Gerstein (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Neurosciences. ; Computational neuroscience. ; Biophysics. ; Science—History. ; Neuroscience. ; Computational Neuroscience. ; Biophysics. ; History of Science.
    In: Springer Nature eBook
    Description / Table of Contents: This book brings together a selection of papers by George Gerstein, representing his long-term endeavor of making neuroscience into a more rigorous science inspired by physics, where he had his roots. Professor Gerstein was many years ahead of the field, consistently striving for quantitative analyses, mechanistic models, and conceptual clarity. In doing so, he pioneered Computational Neuroscience, many years before the term itself was born. The overarching goal of George Gerstein’s research was to understand the functional organization of neuronal networks in the brain. The editors of this book have compiled a selection of George Gerstein’s many seminal contributions to neuroscience--be they experimental, theoretical or computational--into a single, comprehensive volume .The aim is to provide readers with a fresh introduction of these various concepts in the original literature. The volume is organized in a series of chapters by subject, ordered in time, each one containing one or more of George Gerstein’s papers.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 253 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030874476
    Series Statement: Springer Series in Computational Neuroscience,
    URL: https://doi.org/10.1007/978-3-030-87447-6
    DOI: 10.1007/978-3-030-87447-6
    Language: English
    Note: 1. Integrate and fire: RC circuits to model neurons and reward monkeys -- 2. Neuronal spike trains, stochastic point processes, and why George Gerstein’s papers are still worth reading -- 3. Visual Functions of Inferior Temporal Cortex -- 4. Early Days in the Gerstein Lab: Neuronal Plasticity in 1, 2, and 3 Dimensions -- 5. Patterns in Spike Trains -- 6. Introduction to the Gravity Papers -- 7. On correlations and interactions between neurons and with George Gerstein -- 8. Significance of Correlations between Spike Trains -- 9. Spatial-Temporal Spike Patterns -- 10. Does Cross Correlation Have a Unique Interpretation? -- 11. Neuronal Plasticity and my Experience Working with George L. Gerstein -- 12. Auditory Experiments and Modeling -- 13. Thinking about Analysis Methods with George in Philadelphia, Cambridge and Newcastle -- 14. Higher-order Correlations and Synfire Chains -- Nencki Award for George L. Gerstein.
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  • 35
    Online Resource
    Online Resource
    Guidelines for Laboratory Quality Managers (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Food science. ; Food—Analysis. ; Chemistry. ; Chemistry, Organic. ; Food Science. ; Food Chemistry. ; Organic Chemistry.
    In: Springer Nature eBook
    Description / Table of Contents: This useful and extensive set of guidelines is designed to assist food control laboratories in gainingaccreditation from an internationally recognized external body, providing all of the necessary information and practices in an easy-to-read, step-by-step fashion. Authored by an experienced consultant for laboratory accreditation in many different countries, with this text food control lab owners now have all of the up-to-date information they need to gain accreditation in a single source. Guidelines for Laboratory Quality Managers covers the essentials for quality management in the food control laboratory, from testing processes to current quality management systems. The ISO standards for accreditation are extensively explored, including managerial requirements,organizational aspects, complaint handling procedures, internal audits, and sampling. An entire section is dedicated to the implementation of managerial and technical requirements from quality control to program monitoring and evaluation. Analysis selection, preparation, and validation is covered extensively, and an entire section is dedicated to basic statistics from data presentation todistribution. Each section comes with helpful tips for lab managers plus definitions and terms. Comprehensive, easy-to-use and up-to-date, Guidelines for Laboratory Quality Managers isthe guide for accreditation for food control laboratories. .
    Type of Medium: Online Resource
    Pages: XV, 160 p. 34 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031117244
    Series Statement: Integrating Food Science and Engineering Knowledge Into the Food Chain, 14
    URL: https://doi.org/10.1007/978-3-031-11724-4
    DOI: 10.1007/978-3-031-11724-4
    Language: English
    Note: Laboratory management and ISO 17025:2017 -- Essential for Quality management in testing laboratories -- Preparing for analysis: the analytical method -- Statistics for the Quality Control Laboratory -- Uncertainty measurement -- Control Charts and Process capability -- Risk Management.
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  • 36
    Online Resource
    Online Resource
    Technological Advancement in Algal Biofuels Production (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Microbiology. ; Biology—Technique. ; Biotechnology. ; Microbiology. ; Biological Techniques. ; Biotechnology.
    In: Springer Nature eBook
    Description / Table of Contents: This edited book presents all feasible approaches to improve technology of algal biofuels production at both qualitative and quantitative front. The book’s focus in on enhancing mass scale production of algae based biofuels by addressing technological issues and filling the existing gaps to make it smooth for practical as well as commercial implementation. The book also explores in depth analysis of various issues other than technology and related to improve technological significance for practical biofuels production from algae. Low cost strategies and higher mass production is one of the most sounding agenda of the book. The book also evaluates enlighten various sustainable algal biofuels options which are close towards commercial application along with their green future prospect. Societal and environment friendly approach even for commercial application has also been discussed in book. This is a useful reading material for researchers and students of biofuels and reneable energy. .
    Type of Medium: Online Resource
    Pages: XI, 295 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811968068
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-19-6806-8
    DOI: 10.1007/978-981-19-6806-8
    Language: English
    Note: Chapter 1. Biotechnological approaches to enhance algae biofuel production -- Chapter 2. The use of omics technologies, random mutagenesis, and genetic transformation techniques to improve algae for biodiesel industry -- Chapter 3. Algal butanol production: recent developments -- Chapter 4. Algal synthesis of gold nanoparticles: applications in bioenergy -- Chapter 5. Challenges assessment in economic Algal biofuel Production -- Chapter 6. Influence of culture conditions on the microalgae biomass and lipid accumulation -- Chapter 7. Advanced genetic approaches towards custom design microalgae for fourth-generation biofuels -- Chapter 8. Algal biofuel production from municipal waste waters -- Chapter 9. Positive influence and future perspective of marine alga on biofuel production -- Chapter 10. Algae bacterial mixed culture for waste to wealth conversation: a case study.
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  • 37
    Online Resource
    Online Resource
    Paleoneurology of Amniotes : New Directions in the Study of Fossil Endocasts (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Evolution (Biology). ; Zoology. ; Anatomy. ; Evolutionary Biology. ; Paleontology. ; Zoology. ; Anatomy.
    In: Springer Nature eBook
    Description / Table of Contents: TThis book presents a detailed examination of the current state of knowledge in the field of paleoneurology in the main amniote groups (reptiles, birds and mammals), and advances resulting from new non-invasive technologies. The study of fossil endocasts is an area of considerable current interest, and has long been central to our understanding of the evolution of the brain, development of senses and behavioral adaptations in diverse vertebrate groups and across vertebrates as a whole. Recent advances in non-invasive imaging have significantly increased the number of fossil taxa for which brain morphology is known, and it may now be possible to quantitatively analyze the relative size of brain regions. Providing a general overview of current perspectives and problems in evolutionary neuroanatomy, this book is intended for a wide range of readers, including undergraduate and graduate students, teachers, and anyone with a special interest in paleoneurology. It is also useful as supplementary reading for courses in digital anatomy, vertebrate comparative anatomy, computed morphometrics, paleontology, neurology and radiology as well as evolution programs.
    Type of Medium: Online Resource
    Pages: XX, 840 p. 171 illus., 123 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031139833
    URL: https://doi.org/10.1007/978-3-031-13983-3
    DOI: 10.1007/978-3-031-13983-3
    Language: English
    Note: PART 1: FOSSIL ENDOCASTS IN REPTILES AND BIRDS -- Chapter 1 - Onto land and back into water: basal diapsids and marine reptiles -- Chapter 2 - Sauropterygia and Ichthyopterygia: Paleoneurology of secondarily aquatic reptiles -- Chapter 3 - Contrasting brains and bones: implications for turtle paleoneurology -- Chapter 4 - Approaches to the Paleoneurology of Lepidosauromorpha.-Chapter 5 - Paleoneuroanatomy of Triassic archosauriforms and pseudosuchians -- Chapter 6 - Paleoneurology of Crocodylomorpha -- Chapter 7 - Neurosensory evolution in the pterosaurs -- Chapter 8 - Paleoneurology of dinosaur endocasts: past, present, and future research -- Chapter 9 - The evolution of bird brain -- PART 2: FOSSIL ENDOCASTS IN MAMMALS -- Chapter 10 - Paleoneurology of stem and basal Mammalia -- Chapter 11 - Evolution of the brain and sensory structures in monotremes/Evolution of the brain and sensory structures in marsupials -- Chapter 12 - Early evolution of the brain in Primates and their close kin -- Chapter 13 - The brain of condylarthra and extinct Cetartiodactyla -- Chapter 14 - Sirenia fossil endocranial casts: history and evolution -- Chapter 15 - Paleoneurology of the Proboscidea (Mammalia, Afrotheria): insight from the brain endocast, bony labyrinth and infraorbital canal -- Chapter 16 - North American and South American Fossil Rodents: Cranial endocasts of extinct rodents and brain evolution -- Chapter 17 - Parallel patterns in carnivore brain evolution/South American Fossil Carnivorans: Auditory Region of Ursidae and Cranial Endocast of Procyonidae -- Chapter 18 - The Cranial Endocast and Inner Ear Anatomy of Extinct Cingulates -- Chapter 19 - The endocranial cavities of Folivora (Mammalia, Xenarthra): insights from the brain cavity, bony labyrinth and cranial sinuses -- Chapter 20 - Cranial Endocasts and Inner Ear of Notostylopidae and Typotheria/Endocranial Morphology of Toxodontians (Mammalia, Notoungulata) and Brain Evolution in Paleogene Notoungulates -- Chapter 21 - Digital and Natural Cranial Endocasts of Macraucheniidae (Mammalia, Litopterna): Brain and Frontal Sinuses.
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  • 38
    Online Resource
    Online Resource
    Faunal Ecology and Conservation of the Great Nicobar Biosphere Reserve (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Ecology . ; Biotic communities. ; Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Ecology. ; Ecosystems. ; Biodiversity. ; Freshwater and Marine Ecology.
    In: Springer Nature eBook
    Description / Table of Contents: This edited book brings out a comprehensive account of the faunal diversity in Great Nicobar Biosphere Reserve which is part of the Sundaland Biodiversity hotspot. The main focus of this volume is to address the ecological and economic significance of the biodiversity of this region. The book provides latest information on the faunal diversity of Great Nicobar Biosphere. It focuses on various faunal communities of this regions such as Floral diversity, Butterflies, Moths, Dragonflies & Damselflies, Termites, Hymenoptera, Coleoptera, Scorpion, Spiders, Turtle, Nicobar megapode. Chapters in this volume also covers Reptiles & Amphibians, Fishes, Mammals, Land and freshwater Mollusca. Marine animals such as Opisthobranchs, Sponges, Scleractinian Corals and Soft corals, Sea Anemones, Polyclads, Marine Molluscs, Echinoderms are also discussed. It is of interest for the researchers, teachers, scientists, capacity builders, policy makers. Also serve as reading materials for graduate and post graduate students e.g., Wildlife Biology, Forestry, Environmental Science, Wildlife Ecology, Zoology, Life sciences, Parks/Sanctuaries managers, National and International scientists, policy makers will also find this to be a useful document.
    Type of Medium: Online Resource
    Pages: XVI, 666 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811951589
    URL: https://doi.org/10.1007/978-981-19-5158-9
    DOI: 10.1007/978-981-19-5158-9
    Language: English
    Note: 1. Great Nicobar Biospehere reserve: An Overview -- 2. Floral diversity of great nicobar biospehere reserve Andaman & Nicobar Islands, INDIA -- 3. Odonata of great nicobar biosphere reserve -- 4. Butterfly diversity of great nicobar biospehere reserve -- 5. Aquatic beetles of great nicobar biosphere reserve - (Coleoptera: Noteridae, Dytiscidae, and Hydrophildae) -- 6. Moths (Lepidoptera) of great nicobar biosphere reserve -- 7. Termite fauna of great nicobar biosphere reserve, India -- 8. Scorpionida and amblypygi diversity of great nicobar biosphere reseve -- 9. Diversity and species abundance of spiders of great nicobar biosphere reserve -- 10. Non-Marine Molluscs of great nicobar biosphere reserve, andaman and nicobar island, India -- 11. Reptiles of great nicobar biosphere reserve -- 12. Fresh water and estuarine fishes of great nicobar islands -- 13. Diversity and species abundance of bird commnuities in great nicobar biosphere reserve, India -- 14. Present status and distribution of nicobar megapode megapodius nicobariensis in nicobar islands -- 15. Mammalian fauna of great nicobar biosphere reserve -- 16. Status and distribution of long-tailed macaque fascicularis umbrosa miler, 1902 in great nicobar biosphere reserve, India -- 17. Conservation perspectives of dugongs and sea turtles in andaman and nicobar islands -- 18. Mesozooplankton diversity in the marine waters of great nicobar island, andaman and Nicobar Archipelago -- 19. Current status of diversity of marine microplankton from great nicobar island, andaman and nicobar archipelago -- 20. Marine sponges of great nicobar biosphere reserve -- 21. Great Nicobar Biosphere reserve - A Biological treasure trove for scleractinan corals -- 22.Hydrozoan diversity and distribution in great nicobar biosphere reserve -- 23. Diversity and distribution of octocorals (Octocorollia) in great nicobar biosphere reserve -- 24. Status and distribution of sea anemone in great nicobar biosphere reserve -- 25. Polyclads of great nicobar biosphere reserve -- 26. Decapods (Crustacea: Decapoda) of great status of great Nicobar biosphere reserve -- 27. Current status of the marine polychaete (Annelida: Polychaeta) from Nicobar islands -- 28. Diversity and distribution of intertdial mollusca of great nicobar biosphere reserve. 29. Status and distribution of Opisthobranchs of Great nicobar isalnd, India -- 30. Diversity and distribution of echinoderms of great niocobar biosphere reserve, Andaman and Nicobar islands -- 31. Marine Icthyofaunal Diversity in great Nicobar Biosphere resere,- India. 32. Marine Mammals of the Nicobar group of Islands, India.
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  • 39
    Online Resource
    Online Resource
    Techniques in Forage Quality Analysis (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Food science. ; Food—Analysis. ; Chemistry. ; Food Science. ; Food Analysis. ; Food Engineering. ; Food Chemistry.
    In: Springer Nature eBook
    Description / Table of Contents: The book covers different techniques and methodologies involved in the nutritional quality analysis of forages. It also discusses the nutritional quality, anti-nutritional components, factors affecting forage quality, feed processing and conservation. Different techniques and methodologies have been presented in a simplified manner. The book has been divided in separate chapters and each chapter discusses different aspect of forage quality. Further, the book also covers the topics on conservation and processing of forages and management techniques for improving the forage nutritional quality. This book is an essential source of information for research scholars, post-graduate students and scientists working on forage quality estimation and also in livestock and dairy industries.
    Type of Medium: Online Resource
    Pages: XVII, 233 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811960208
    URL: https://doi.org/10.1007/978-981-19-6020-8
    DOI: 10.1007/978-981-19-6020-8
    Language: English
    Note: 1. Introduction -- 2. Forage quality vis-a vis livestock productivity -- 3. Forage Quality Indices -- 4. Forage quality components -- 5. Management of anti-nutrients in forages -- 6. General scheme for forage quality analysis -- 7. Laboratory essentials for forage evaluation -- 8. Solutions and buffers in estimations -- 9. Estimation of nutritional components in forages -- 10. Estimation of anti-quality and anti-nutritional factors in forages -- 11. Estimation of mineral content in forages -- 12. Estimation of phytochemicals and enzyme activities in forages -- 13. Quality Estimation of Natural Grasslands and Pastures. 14. Nutritional Quality of Important Forages -- 15. Conservation and processing of forages -- 16. Factors Affecting Forage Quality -- 17. Forage Nutritional Quality Management.
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  • 40
    Online Resource
    Online Resource
    Mineralogical Analysis Applied to Forensics : A Guidance on Mineralogical Techniques and Their Application to the Forensic Field (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Mineralogy. ; Forensic sciences. ; Soil science. ; Mineralogy. ; Forensic Science. ; Soil Science.
    In: Springer Nature eBook
    Description / Table of Contents: This book illustrates the main modern mineralogical analytical procedures that can be applied for forensic purposes on various typologies of materials and substances and has both theoretical and practical approach. Moreover, it focuses on all those challenges that can arise with forensic analysis, such as the choice of the most proper mineralogical techniques as a function of the material and its quantity, destructive and non-destructive analyses, sampling procedures, mineralogical analysis of micro-traces, correct preparation of the samples, correct calibration and analytical conditions of the laboratory instrumentation. Numerous case studies on criminal offenses against persons, environment and Cultural Heritage are illustrated. .
    Type of Medium: Online Resource
    Pages: XI, 311 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031088346
    Series Statement: Soil Forensics,
    URL: https://doi.org/10.1007/978-3-031-08834-6
    DOI: 10.1007/978-3-031-08834-6
    Language: English
    Note: 1. Optical microscopy applied to forensics -- 2. X-ray powder diffraction (XRPD -- 3. Scanning Electron Microscopy, Electron Microanalysis and automated SEM for forensic science -- 4. Infrared spectroscopy -- 5. Raman spectroscopy and forensic mineralogy -- 6. ICP-MS for forensic science -- 7. Simultaneous Thermal Analysis (STA): a powerful tool for forensic purposes -- 8. X-ray fluorescence -- 9. Isotopic analysis techniques applied in forensics. New frontiers of isotope geochemistry -- 10. Image analysis in forensic mineralogy.
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  • 41
    Online Resource
    Online Resource
    Marine Mammals : A Deep Dive into the World of Science (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Zoology. ; Veterinary medicine. ; Freshwater ecology. ; Marine ecology. ; Zoology. ; Veterinary Science. ; Freshwater and Marine Ecology.
    In: Springer Nature eBook
    Description / Table of Contents: This highly-readable Open Access textbook provides basic background information about marine mammals and anthropogenic impacts on them. The book includes inspiring exercises for education school programs in natural sciences. The book also provides advice on career paths using case studies of marine scientists and veterinarians describing their journeys from student to profession. By sharing real-life career paths, readers find answers to questions such as “What needs to be considered when choosing a career in science?” and “What kind of tasks do scientists undertake on a daily basis?” Marine mammals are amongst some of the most celebrated creatures on Earth, with their high intelligence, social and communicating skills, and capacity for deep diving. Alongside general information about marine mammals, the book aims at generating awareness of the impact of litter and noise pollution on the marine environment using marine mammals as an example. Huge numbers of marine animals, including marine mammals, die every year from entanglement in fishing gear, by ingestion of litter or because of chemical pollution. In the last decade many technological and scientific tools have been developed to aid research, for instance miniaturised sound recorders which can be attached to cetaceans and seals and record noise levels around them, their vocal production as well as their diving behaviour. This Open Access textbook can be used by undergraduate students interested in the fundamentals of marine mammal biology and medicine, and in pursuing the profession of a marine scientist. .
    Type of Medium: Online Resource
    Pages: X, 95 p. 32 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031068362
    URL: https://doi.org/10.1007/978-3-031-06836-2
    DOI: 10.1007/978-3-031-06836-2
    Language: English
    Note: Chapter 1. Who are the marine mammals? -- Chapter 2. Marine mammal acoustics -- Chapter 3. Whaling, seal culling, and the effect of fisheries on marine mammals -- Chapter 4. Plastic debris and its impacts on marine mammals -- Chapter 5. Chemical pollution and diseases of marine mammals -- Chapter 6. How to become a marine mammal scientist.
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  • 42
    Online Resource
    Online Resource
    Our Carbon Hoofprint : The Complex Relationship Between Meat and Climate (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Agriculture. ; Environment. ; Food science. ; Agriculture. ; Environmental Sciences. ; Food Science.
    In: Springer Nature eBook
    Description / Table of Contents: In the ongoing effort to combat global climate catastrophe, animal agriculture has long been a subject of contention. On the one hand, most agree that across the world increasing meat and dairy consumption are accelerating anthropogenic climate change. On the other hand, proponents of the livestock industry argue that modern advancements reduce greenhouse gas emissions from efficient livestock production to negligible quantities. Some even maintain that grass-based livestock production has a net positive impact on the environment, due to the carbon sequestration caused by grazing. Whom are we to believe? This book shows us that the answer is not so clear-cut. Beginning with the implications of the UN’s Livestock’s Long Shadow report, it breaks down the blind spots and highlights the insights of the most prominent pro-meat arguments, as well as of the push for a global switch to vegetarianism. While advances in efficiency might reduce greenhouse gas emissions per unit of meat or milk produced, attendant decreases in cost can enable overconsumption and thus produce more waste. And while carbon sequestration is beneficial, it is not a reliable cure-all for the industry. Due to the economics of farming, however, eliminating meat consumption may not even reduce emissions at all. The truth about livestock production is much more nuanced but, luckily, also far more holistic. The future of agricultural policy will have to take into consideration factors such as human health and economics, as well as climate. Eschewing ideology for empirical rigor, this book paves an actionable path forward for both consumers and producers, offering unique solutions for each livestock system and simple, everyday adjustments for the average omnivore.
    Type of Medium: Online Resource
    Pages: VIII, 231 p. 96 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031090233
    Series Statement: Food and Health,
    URL: https://doi.org/10.1007/978-3-031-09023-3
    DOI: 10.1007/978-3-031-09023-3
    Language: English
    Note: Preface -- How we got here, and where we need to go: The bitter fight about meat and climate -- The consequences for climate of meat consumption -- The Limits of Vegetarianism -- The Benefits of Modern Efficiency -- The Limits of Efficiency -- The Miracle of Grass -- The limits of grass -- Lightening our Carbon Hoofprint -- Policy Pathways -- Index.
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  • 43
    Online Resource
    Online Resource
    Virus-Host Interactions : Methods and Protocols (2023)
    New York, NY : Springer US
    Details
    Subject(s): Virology. ; Biological models. ; Virology. ; Biological Models.
    In: Springer Nature eBook
    Description / Table of Contents: This detailed volume spotlights methods to investigate a variety of virus-host interactions in humans, other mammals, fish, or insects. It explores viruses such as white spot syndrome virus (WSSV), honeybee viruses, Nipah virus, EBV, SVCV, HSV-1, HIV-1, A H1N1, and SARS-CoV-2, as well as applications of techniques such as qPCR, serum antibody responses, 4C analysis, cell membrane fusion, biosensors, computational modelling, quantitative proteomics, and other genetic tools to decipher those viral infections and interactions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Virus-Host Interactions: Methods and Protocols serves as a valuable resource for researchers both in academia and in the biosciences industry who are engaged in the search for a better understanding of threatening virus-hosts interactions, virus detection, their characterization, and ultimately their taming and control.
    Type of Medium: Online Resource
    Pages: XI, 202 p. 44 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9781071628959
    Series Statement: Methods in Molecular Biology, 2610
    URL: https://doi.org/10.1007/978-1-0716-2895-9
    DOI: 10.1007/978-1-0716-2895-9
    Language: English
    Note: Genetic Tools for Studying the Roles of Sphingolipids in Viral Infections -- Detection of Serum Antibody Responses in Nipah Virus-Infected Pigs -- Computational Integration of HSV-1 Multi-Omics Data -- A Cell Membrane Fusion Assay for the Fish Pathogen Spring Viremia of Carp Virus (SVCV) -- Viral Quantification in Bee Samples Using Synthetic DNA Sequences with Real Time PCR (qPCR) -- Inhibition of White Spot Syndrome Virus (WSSV) in Pacific White Shrimp (Litopenaeus vannamei) Using Polyamine-Modified Carbon Quantum Dots -- Computational Modeling of IN-CTD/TAR Complex to Elucidate Additional Strategies to Inhibit HIV-1 Replication -- Protein-Protein and Protein-RNA Interaction Assays to Determine Similarity of INI1/SMARCB1 and TAR RNA in Binding to HIV-1 Integrase -- 4C Analysis of EBV-Host DNA Interactome -- Detection Methods for H1N1 Virus -- Detection of SARS-CoV-2 in Human Breast Milk -- The Rhizopus Holobiont: A Model to Decipher Fungal-Bacterial-Viral Symbioses -- Combining Metabolic Pulse Labeling and Quantitative Proteomics to Monitor Protein Synthesis upon Viral Infection -- Three-Dimensional Human Brain Organoids to Model HIV-1 Neuropathogenesis -- Characterization of SARS-CoV-2 Glycoprotein Using a Quantitative Cell-Cell Fusion System -- A Lentiviral Pseudotype System to Characterize SARS-CoV-2 Glycoprotein.
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  • 44
    Online Resource
    Online Resource
    Mexican Fauna in the Anthropocene (2023)
    Cham : Springer International Publishing
    Details
    Subject(s): Biodiversity. ; Biotic communities. ; Conservation biology. ; Ecology . ; Vertebrates. ; Invertebrates. ; Biodiversity. ; Ecosystems. ; Conservation Biology. ; Vertebrate Zoology. ; Invertebrate Zoology.
    In: Springer Nature eBook
    Description / Table of Contents: This contributed volume presents an analysis of the current conservation status of major faunal groups in Mexico. The chapters describe a prognosis of future challenges, and also explore the expanding threats inherent in the Anthropocene within the context of the unique physical, biological and cultural aspects of the nation. Covering 27 chapters, and written by Mexican and international authors, this book analyzes a wide range of vertebrate and invertebrate animal taxa, their ecosystems and the critical processes related to their present conservation status. This volume is an important reference material for researchers, conservationists and students interested in the biological and ecological processes shaping the Mexican fauna.
    Type of Medium: Online Resource
    Pages: XVII, 597 p. 50 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031172779
    URL: https://doi.org/10.1007/978-3-031-17277-9
    DOI: 10.1007/978-3-031-17277-9
    Language: English
    Note: 1.1 General Introduction Principal -- 2. Zoloogical Groups -- 2.1 Arachnids -- 2.2 Insects: Migrants, endemics, and old to new pests -- 2.3 Freshwater decapod crustaceans: the challenges of documenting and preserving a very diverse fauna -- 2.4 Mexican molluscs: In the process of a 'silent extinction' -- 2.5 Amphibians and reptiles -- 2.6 Anthropocene impacts on the Mexican freshwater fish fauna -- 2.7 Mexican avifaunas of the Anthropocene -- 2.8 Marine birds -- 2.9 Terrestrial mammals -- 2.10 Marine mammals -- 2.11Mexican bats: conservation challenges in the Anthropocene -- 3. Ecosytems -- 3.1 The impact of the growth of urban environments on Mexican fauna -- 3.2 Anchialine fauna of the Yucatan Peninsula -- 3.3 Semi-terrestrial and aquatic invertebrates and fish in mangroves in México -- 3.4 Defaunation of Mexican tropical forests3.5 Mezcal boom and extinction debts in Mexican arid ecosystems -- 3.6 Deep sea life -- 3.7 The importance of agroecosystems for the Mexican fauna -- 3.8 The salamanders of the Mexican cloud forest -- 3.9 Human effects on caves in Mexico -- 3.10 Fauna of lakes and rivers -- 3.11 Coral reef faunal assemblages in the Mexican Caribbean: assessing the cryptic biodiversity -- 4 Processes -- 4.1 Contemporary climate change impacts on Mexican fauna -- 4.2 Invasive alien species of invertebrates and fishes introduced to Mexican freshwater systems -- 4.3 Are marine fisheries sustainable? -- 4.4 Pest dynamics in Mexican forests -- 4.5 Pollination by wild and managed animal vectors -- 4.6 Social participation strategies for the conservation of Mexican fauna -- 4.7 Citizen science for deep ocean biodiversity: a crowdsourcing tool in support of conservation -- 4.8 Legal actions for the conservation of fauna.
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  • 45
    Online Resource
    Online Resource
    Regenerative Medicine : Emerging Techniques to Translation Approaches (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Regenerative medicine. ; Stem cells. ; Nervous system—Regeneration. ; Biomaterials. ; Cells. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology. ; Regeneration and Repair in the Nervous System. ; Biomaterials-Cells.
    In: Springer Nature eBook
    Description / Table of Contents: This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.
    Type of Medium: Online Resource
    Pages: XV, 390 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811960086
    URL: https://doi.org/10.1007/978-981-19-6008-6
    DOI: 10.1007/978-981-19-6008-6
    Language: English
    Note: Chapter 1. Regeneration and tissue microenvironment -- Chapter 2. Non stem cell mediated tissue regeneration and repair -- Chapter 3. Immunological Perspectives Involved in Tissue Engineering -- Chapter 4. Advances in Medical Imaging for Wound Repair and Regenerative Medicine -- Chapter 5. Role of Biosensors in Regenerative Therapeutics: Past, Present & Future Prospects -- Chapter 6. Acute and Chronic Wound Management: Assessment, Therapy and Monitoring Strategies -- Chapter 7. Stem cells and therapies in cardiac regeneration -- Chapter 8. Hydrogel-based Tissue-mimics for Vascular Regeneration and Tumor Angiogenesis -- Chapter 9. Advances in 3D Printing Technology for Tissue Engineering -- Chapter 10. Adult Neurogenesis: A Potential Target for Regenerative Medicine -- Chapter 11. Regenerative approaches in the nervous system -- Chapter 12. Prenatal interventions for the treatment of congenital disorders -- Chapter 13. Understanding LncRNAs in biomaterials development for osteointegration -- Chapter 14. Current approaches in vertical bone augmentation and large bone deficiencies in the oro-facial region -- Chapter 15. In-vitro and in-vivo tracking of cell-biomaterial interaction to monitor the process of bone regeneration -- Chapter 16. The Prospects of RNAs and Common Significant Pathways in Cancer Therapy and Regenerative Medicine.
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  • 46
    Online Resource
    Online Resource
    Science and Engineering of Chinese Liquor (Baijiu) : Microbiology, Chemistry and Process Technology (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Biology—Technique. ; Food—Microbiology. ; Food science. ; Biological Techniques. ; Food Microbiology. ; Food Science.
    In: Springer Nature eBook
    Description / Table of Contents: This book provides a cutting-edge scientific overview of Chinese liquor, also known as Baijiu. Chinese liquor is one of the world’s most ancient fermented alcoholic beverages. Fermented foods and beverages are consumed worldwide as an indispensable constituent in our daily life. However, most fermented foods rely on traditional techniques with limited known scientific knowledge. These indigenous processes are typically empirical without scientifically-based control and technological insights. The book analyses Chinese liquor processing on the three most important disciplines of fermented foods: process technology/engineering, flavor chemistry, and microbiology. It also addresses the perspectives and future research needs associated with spontaneous fermented foods. This book offers a deep understanding of the science of Chinese liquor production to students, researchers, and related practitioners both in the academic and the industry. It would also benefit many other fields of fermented foods for their optimization, standardization, and modernization.
    Type of Medium: Online Resource
    Pages: XIX, 608 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811921957
    URL: https://doi.org/10.1007/978-981-19-2195-7
    DOI: 10.1007/978-981-19-2195-7
    Language: English
    Note: Chapter 1. History and Technology of Chinese Liquor -- Chapter 2. Classification of Chinese Baijiu -- Chapter 3.Baijiu-Making Equipments -- Chapter 4. Process Principles and Engineering of Solid-State Fermentation of Chinese Liquor -- Chapter 5. Solid-state Distillation of Chinese Liquor (Baijiu) -- Chapter 6. History and advance of flavour research of Baijiu -- Chapter 7. Sensory Properties of Baijiu -- Chapter 8. Chemical Components of Chinese Baijiu -- Chapter 9. Microbial Diversities During Chinese Liquor Fermentations -- Chapter 10. Composition and Succession of the Microbiota in Light-Aroma Baijiu Production -- Chapter 11. Diversity and Succession of the Microbiota in Sauce-Aroma Baijiu -- Chapter 12. Composition, Succession and Key Species of Microbiota in Strong-Aroma Baijiu Production -- Chapter 13. Functional Microorganisms Associated with Baijiu Fermentation -- Chapter 14. Microbial interaction in Chinese liquor fermentation -- Chapter 15. Regulation of the microbiota in Chinese liquor fermentation process -- Chapter 16. Challenges and Perspectives (Strategies).
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  • 47
    Online Resource
    Online Resource
    Emerging Anti-Aging Strategies (2023)
    Singapore : Springer Nature Singapore
    Details
    Subject(s): Regenerative medicine. ; Medicine—Research. ; Biology—Research. ; Genetics. ; Epigenetics. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Genetics. ; Epigenetics.
    In: Springer Nature eBook
    Description / Table of Contents: The book focuses on the emerging anti-aging approaches for maintaining better health in old age. It provides a current understanding of the underlying principle, possible targets, implementation approaches, and efficacy of the various anti-aging strategies. The chapters include a wide range of topics incorporating the major advances in anti-aging strategies, including telomerase activation, stem cell therapy, autophagy induction, sirtuin activation, and dietary restrictions. Further, it discusses the epigenetic mechanisms underlying aging-related processes and epigenetic strategies to delay and reverse aging-related diseases. The book covers the strategy based on tissue engineering and regenerative medicine for understanding the complexity of aging and restoring the functionalities of organ systems. It further presents the applications of melatonin supplementation-based anti-aging therapeutic intervention. Finally, the book reviews the ethical dimension of anti-aging intervention strategies. This book is immensely useful to scientists and researchers from various disciplines in the life sciences. .
    Type of Medium: Online Resource
    Pages: XIV, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811974434
    URL: https://doi.org/10.1007/978-981-19-7443-4
    DOI: 10.1007/978-981-19-7443-4
    Language: English
    Note: Chapter 1. Genetics and Epigenetics of Ageing and Age Associated Diseases -- Chapter 2. Coenzyme Q as an anti aging strategy -- Chapter 3. Autophagy as a Promising Therapeutic Target in Age-Associated Neurodegenerative Disorders -- Chapter 4. Glycolytic inhibitors as Caloric Restriction Mimetics (CRM) -- Chapter 5. Anti-aging and rejuvenation based on stem cell therapy -- Chapter 6. Novel strategies for metformin as an anti-aging drug in skin aging -- Chapter 7. Anti-inflammatory-dependent anti-aging strategies -- Chapter 8. Spermidine, an autophagy inducer, as a therapeutic anti-aging strategy -- Chapter 9. Melatonin in Aging and Aging Related Disorders -- Chapter 10. Intermittent fasting as an anti- aging strategy -- Chapter 11. The role of curcumin as an anti-aging compound -- Chapter 12. The Role of Telomerase Activators in Anti-Aging Strategies and Their Clinical Potential -- Chapter 13. Clinical Laboratories and Their Role in Anti-Aging Strategies -- Chapter 14. Antiaging strategies based on sirtuin activation -- Chapter 15. A vaccine for the pandemic of ageing? Conceptual and ethical issues -- Chapter 16. Cognitive and emotional ageing across the life span: Implications for building the cognitive reserve and resilience -- Chapter 17. Tissue reconstructive & regenerative medicine approach as an anti-ageing intervention: Relevance to age-induced Osteoarthritis -- Chapter 18. Age-Adjustment Expertise in Animal Models of Human Diseases.
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  • 48
    Unknown
    Unknown
    Physics for clinical oncology / (2023)
    Oxford : Oxford University Press
    Details
    Type of Medium: Unknown
    Pages: xi, 281 p. : , ill.
    Edition: 2nd ed.
    ISBN: 9780198862864
    Series Statement: Radiotherapy in practice
    Language: English
    Location/Call number: Library / QZ269:182(2)
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