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    Wiley-Blackwell
    Publication Date: 2018-01-06
    Description: Tumour heterogeneity is an important feature of colorectal cancer (CRC) manifested by dynamic changes in gene expression, protein expression, and availability of different tumour subtypes. Recent publications in the past ten years have revealed proteome heterogeneity between different colorectal tumours and within the same tumour site. This paper reviews recent research works on the proteome heterogeneity in CRC, which includes the heterogeneity within a single tumour (intratumour heterogeneity), between different anatomical sites at the same organ, and between primary and metastatic sites (intertumour heterogeneity). The potential use of proteome heterogeneity in precision medicine and its implications in biomarker discovery and therapeutic outcomes will be discussed. Identification of the unique proteome landscape between and within individual tumours is imperative for understanding cancer biology and the management of CRC patients. This article is protected by copyright. All rights reserved
    Print ISSN: 1615-9853
    Electronic ISSN: 1615-9861
    Topics: Medicine
    Published by Wiley-Blackwell
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