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  • 1
    Publication Date: 2018-08-29
    Description: The cytokines of the transforming growth factor–β (TGF-β) family promote the growth and differentiation of multiple tissues, but the role of only the founding member, TGF-β, in regulating the immune responses has been extensively studied. TGF-β is critical to prevent the spontaneous activation of self-reactive T cells and sustain immune homeostasis. In contrast, in the presence of proinflammatory cytokines, TGF-β promotes the differentiation of effector T helper 17 (T H 17) cells. Abrogating TGF-β receptor signaling prevents the development of interleukin-17 (IL-17)–secreting cells and protects mice from T H 17 cell–mediated autoimmunity. We found that the receptor of another member of TGF-β family, bone morphogenetic protein receptor 1α (BMPR1α), regulates T helper cell activation. We found that the differentiation of T H 17 cells from naive CD4 + T cells was inhibited in the presence of BMPs. Abrogation of BMPR1α signaling during CD4 + T cell activation induced a developmental program that led to the generation of inflammatory effector cells expressing large amounts of IL-17, IFN-, and TNF family cytokines and transcription factors defining the T H 17 cell lineage. We found that TGF-β and BMPs cooperated to establish effector cell functions and the cytokine profile of activated CD4 + T cells. Together, our data provide insight into the immunoregulatory function of BMPs.
    Print ISSN: 1945-0877
    Topics: Medicine
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