Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: Germany ; MODEL ; MODELS ; COHORT ; EPIDEMIOLOGY ; POPULATION ; GENES ; PATIENT ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; VARIANTS ; CARE ; HEALTH ; genetics ; smoking ; REPLICATION ; TOBACCO ; SINGLE ; REGRESSION ; VARIANT ; DETERMINANTS ; DEPENDENCE ; SINGLE NUCLEOTIDE POLYMORPHISMS ; CATECHOL-O-METHYLTRANSFERASE ; PHARMACOGENETICS ; GENOTYPE ; EVENTS ; pharmacology ; USA ; smoking cessation ; population-based ; biotechnology ; GENERAL-POPULATION ; NICOTINE DEPENDENCE ; COMT ; Genetic ; CONFIDENCE ; historical cohort study ; PROPORTION
    Abstract: Genome-wide studies have identified single nucleotide polymorphisms associated with smoking behaviour and nicotine dependence. Less is known about genetic determinants of smoking cessation, but rs4680 in COMT has recently been shown to explain a substantial proportion of the variation in cessation in the general population. We attempted to replicate the reported, clinically relevant effect in a population-based retrospective cohort analysis of 1443 ever-heavy smokers, of whom 925 had reached abstinence. In Cox regression models, neither rs4680 nor two polymorphisms nearby were associated with smoking cessation. The adjusted relative cessation rate (95 percent confidence interval) in rs4680 methionine carriers in reference to valine homozygotes was 0.97 (0.83-1.12). The absence of a significant effect of rs4680 in this statistically well-powered study - the 95% confidence interval even excluding the previously reported effect - highlights the need for rigorous replication efforts and suggests that rs4680 genotype should not yet be considered informative for smoking patient care. Pharmacogenetics and Genomics 19:657-659 (C) 2009 Wolters Kluwer Health / Lippincott Williams & Wilkins
    Type of Publication: Journal article published
    PubMed ID: 19584770
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...