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    Keywords: GROWTH ; IN-VITRO ; tumor ; IN-VIVO ; MODEL ; VITRO ; VIVO ; CT ; kidney ; MRI ; BIOLOGY ; PARTICLES ; polymer ; SURFACE ; CONTRAST AGENTS ; CHEMISTRY ; SCIENCE ; CORE ; NANOPARTICLES ; embolization ; CORE PARTICLE ; BIOMEDICAL APPLICATIONS ; BULKING AGENTS ; MICROSPHERES ; PARTICULATE EMBOLI ; MODALITY ; MAGNETIC HYPERTHERMIA ; NARROW SIZE DISTRIBUTION ; RADIOPAQUE POLYMERIC BIOMATERIALS ; RAY-IMAGING APPLICATIONS
    Abstract: Core P(MAOETIB-GMA) microparticles of 40-200 mu m were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic gamma-Fe2O3/P(MAOETIB-GMA) core shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat's kidney tumor embolization model
    Type of Publication: Journal article published
    PubMed ID: 20443579
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