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    Keywords: measurement ; CANCER ; radiotherapy ; tumor ; Germany ; LUNG ; IMAGES ; lung cancer ; LUNG-CANCER ; TISSUE ; TUMORS ; PATIENT ; MRI ; CYCLE ; SEQUENCE ; STAGE ; RADIATION-THERAPY ; MOBILITY ; REGION ; REGIONS ; WALL ; CURVES ; MOTION ; FUTURE ; LINEAR-ACCELERATOR ; LOCATION ; dynamic MRI ; TRUEFISP ; PULMONARY-FUNCTION ; EXTERNAL-BEAM RADIOTHERAPY ; breathing cycle ; CT SCANS ; DIAPHRAGM ; HEALTHY-SUBJECTS ; lung MRL radiotherapy ; tumor diameter
    Abstract: Background and purpose: To assess the influence of tumor diameter on tumor mobility and motion of the tumor bearing hemithorax during the whole breathing cycle in patients with stage I non-small-cell lung cancer (NSCLC) using dynamic MRI. Patients and methods: Breathing cycles of thirty-nine patients with solitary NSCLCs were examined using a trueFISP sequence (three images per second). Patients were divided into three groups according to the maximal tumor diameter in the transverse plane ( 〈3, 3-5 and 〉5 cm). Continuous time-distance curves and deep inspiratory and expiratory positions of the chest wall, the diaphragm and the tumor were measured in three planes. Motion of tumor-bearing and corresponding contralateral non-tumor bearing regions was compared. Results: Patients with a tumor 〉3 cm showed a significantly lower diaphragmatic motion of the tumor bearing compared with the non-tumor bearing hemithorax in the craniocaudal (CC) directions (tumors 3-5 cm: 23.4 +/- 1.2 vs 21.1 +/- 1.5 cm (P 〈0.05); tumors 〉5 cm: 23.4 +/- 1.2 vs 20.1 +/- 1.6 cm (P 〈0.01). Tumors 〉5 cm in the lower lung region showed a significantly lower mobility compared with tumors 〈3 cm (1.8 +/- 1.0 vs 3.8 +/- 0.7 cm, P 〈0.01) in the CC directions. Conclusions: Dynamic MRI is a simple non-invasive method to differentiate mobility of tumors with different diameters and its influence on the surrounding tissue. Tumor diameter has a significant influence on tumor mobility and this might be taken into account in future radiotherapy planning, (C) 2004 Elsevier Ireland Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15588881
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