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    Keywords: measurement ; BLOOD ; Germany ; VOLUME ; TIME ; BLOOD-FLOW ; SIMULATION ; blood flow ; MR ; SIGNAL ; MAGNETIC-RESONANCE ; magnetic resonance imaging ; NMR ; ARTERY ; radiology ; 2D ; interventional ; STENOSIS ; catheterization ; intra-arterial flow measurements ; MR-compatible devices ; PULSEWAVE VELOCITY ; STENT PLACEMENT ; TARDUS
    Abstract: Flow measurements can be used to quantify blood flow during MR-guided intravascular interventional procedures. In this study, a fast flow measurement technique is proposed that quantifies flow velocities in the vicinity of a small RF coil attached to an intravascular catheter. Since the small RF coil receives signal from only a limited volume around the catheter, a spatially nonselective signal reception is employed. To enhance signal from flowing blood, and suppress unwanted signal contributions from static material, a slice-selective RF excitation is used. At a velocity sensitivity of 150 cm/s, a temporal resolution of 2 x TR = 10.2 ms can be achieved. The flow measurement is combined with an automatic slice positioning to facilitate measurements during interventional procedures. The influence of the catheter position in the blood vessel on the velocity measurement was analyzed in simulations. For blood vessels with laminar flow, the simulation showed a systematic deviation between catheter measurement and true flow between -15% and 80%. In four animal experiments, the catheter velocity measurement was compared with results from a conventional ECG-triggered 2D phase-contrast (PC) technique. The shapes of the velocity time curves in the abdominal aorta were nearly identical to the conventional measurements. A relative scaling factor of 0.69-1.19 was found between the catheter velocity measurement and the reference measurement, which could be partly explained by the simulation results. (C) 2004 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 15334577
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