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    Keywords: CANCER ; PROSTATE ; QUANTIFICATION ; SYSTEM ; CONFORMAL RADIOTHERAPY ; EXPERIENCE ; RADIATION-THERAPY ; dynamic MRI ; ORGAN MOTION ; MOVEMENT ; CINE-MRI ; GLAND ; BEAM COMPUTED-TOMOGRAPHY ; INTRAFRACTION MOTION
    Abstract: To investigate prostate movement during deep breathing and contraction of abdominal musculature by means of dynamic MRI and analyze implications for image-guided radiotherapy of prostate cancer. A total of 43 patients and 8 healthy volunteers were examined with MRI. Images during deep respiration and during contraction of abdominal musculature (via a coughing maneuver) were obtained with dynamic two-dimensional (2D) balanced SSFP; 3 frames/s were obtained over an acquisition time of 15 s. Images were acquired in sagittal orientation to evaluate motion along both the craniocaudal (cc)-axis and anteroposterior (ap)-axis. Prostate motion was quantified semi-automatically using dedicated software tools. Respiratory induced mean cc-axis displacement of the prostate was 2.7 +/- 1.9 (SD) mm (range, 0.5-10.6 mm) and mean ap-axis displacement 1.8 +/- 1.0 (SD) mm (range, 0.3-10 mm). In 69% of the subjects, breathing-related prostate movements were found to be negligible (〈 3 mm). The prostate displacement for abdominal contraction was significantly higher: mean cc-axis displacement was max. 8.4 +/- 6.7 (SD) mm (range, 0.6-27 mm); mean anteroposterior movement was 8.3 +/- 7.7 (SD) mm (range, 0.7-26 mm). Dynamic MRI is an excellent tool for noninvasive real-time imaging of prostate movement. Further investigations regarding possible applications in image-guided radiotherapy, e.g., for individualized planning and in integrated linac/MRI systems, are warranted
    Type of Publication: Journal article published
    PubMed ID: 21713396
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