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    Keywords: brain ; IMAGES ; imaging ; SYSTEM ; TISSUE ; CONTRAST ; MR ; MRI ; SEQUENCE ; SEQUENCES ; SIGNAL ; FIELD ; WATER ; magnetic resonance imaging ; NMR ; PARAMETERS ; MR imaging ; HEALTHY-VOLUNTEERS ; methods ; technique ; correlation ; Sensitivity and Specificity ; LIQUID ; PHANTOMS ; DISTANCES ; Image Processing,Computer-Assisted ; Protons ; Quantum Theory
    Abstract: Dipole-dipole interactions in 1H NMR of liquids permit a new tissue contrast in MR imaging (MRI). For this purpose, the CRAZED (COSY Revamped by Asymmetric Z-gradient Echo Detection) sequence which simply consists of two radiofrequency pulses of delay tau and a magnetic field gradient pulse of strength G, is applied to create intermolecular multiple-quantum coherences of dipolar-coupled ensembles of water protons with spatial distance d = pi/(gammaGtau). As a consequence, the measured signal originates from "sources" that have a tunable dimension. CRAZED was first applied to MR imaging at 1.5 T by Zhong et al. To study the contrast properties and influence of sequence parameters of this technique, we implemented different sequences of this type on a clinical 1.5-T whole-body tomograph. The sequences were optimized in experiments with agar gel phantoms. We obtained images with dipolar contrast from the brain of healthy volunteers. The gradient system enabled correlation distances d in the range of 0.05 mm to 1 mm
    Type of Publication: Journal article published
    PubMed ID: 16986458
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