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    Keywords: CELLS ; tumor ; CELL ; Germany ; PROTEIN ; PROTEINS ; cell line ; LINES ; CONTRAST ; BIOLOGY ; CELL-LINES ; MOLECULAR-BIOLOGY ; METASTASIS ; CELL-LINE ; LINE ; NUCLEUS ; MAMMALIAN-CELLS ; NETHERLANDS ; LIVING CELLS ; BEHAVIOR ; cell lines ; DIFFUSION ; fluorescence correlation spectroscopy ; molecular biology ; molecular ; RE ; SCALE ; SIZE ; ANOMALOUS DIFFUSION ; LATERAL DIFFUSION ; cell size ; compartment ; CYTOPLASM ; ANOMALOUS SUBDIFFUSION ; ARCHIPELAGO ; FLUIDS ; FORCE MICROSCOPY ; macromolecular crowding ; viscoelastic ; VISCOELASTICITY
    Abstract: Macromolecular crowding provides the cytoplasm and the nucleoplasm with strongly viscoelastic properties and renders the diffusion of soluble proteins in both fluids anomalous. Here, we have determined the nanoscale viscoelasticity of the cytoplasm and the nucleoplasm in different mammalian cell lines. In contrast to the cell-specific response on the macroscale the nanoscale viscoelasticity (i.e. the behavior on length scales about 100-fold smaller than the cell size) only showed minor variations between different cell types. Similarly, the associated anomalous diffusion properties varied only slightly. Our results indicate a conserved state of macromolecular crowding in both compartments for a variety of mammalian cells with the cytoplasm being somewhat more crowded than the nucleus. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17923125
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