Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: APOPTOSIS ; CANCER ; proliferation ; BLOOD ; CELL ; CELL-PROLIFERATION ; Germany ; MODEL ; MODELS ; COHORT ; RISK ; RISKS ; SITE ; PROTEIN ; PROTEINS ; colon ; BINDING ; ASSOCIATION ; NO ; resistance ; NUMBER ; AGE ; WOMEN ; colorectal cancer ; OBESITY ; COLORECTAL-CANCER ; COUNTRIES ; RATES ; cancer risk ; BINDING-PROTEINS ; DIET ; case-control studies ; DIABETES-MELLITUS ; EPIC ; nutrition ; FACTOR-I ; REGRESSION-MODELS ; physical activity ; BINDING PROTEIN ; insulin ; SERUM ; IGF-I ; ONCOLOGY ; BINDING-PROTEIN ; case-control study ; REGRESSION ; ASSOCIATIONS ; secretion ; BODY-SIZE ; PHYSICAL-ACTIVITY ; LEVEL ; biomarker ; case control studies ; pancreatic ; BLOOD-GLUCOSE ; INSULIN-RESISTANCE ; rectum ; USA ; prospective ; rectal cancer ; prospective study ; CANCERS ; CANCER-RISK ; C-PEPTIDE ; IGFBP-1 ; colorectal ; BINDING PROTEINS ; LOGISTIC-REGRESSION ; IGFBP-2 ; FACTOR BINDING PROTEIN-1 ; IGF ; insulin resistance ; GROWTH-FACTOR (IGF)-I
    Abstract: Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR = 1.56, 95% CI = 1.16-2.09, p(trend) 〈 0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR = 1.37, 95% CI = 1.00-1.88, p(trend) = 0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR 1.67, 95% CI = 1.14-2.46, p(trend) 〈 0.01) than in the rectum (OR 1.42, 95% CI = 0.90-2.25, p(trend) = 0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk. (C) 2007 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17372899
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...